Mechanistic knowledge surrounding three biological phenomena: tau modification/aggregation, nicotinic receptor signalling, and proteostasis in the context of neurodegenerative disease
Each node in a BEL graph is assigned a type. Most nodes are then identified with a namespace:identifier pair, or a definition based on other nodes as in the case of complexes, composites, and chemical reactions.
| Reference | BEL |
|---|---|
| pmid:30046111 | tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Blood), toLoc(MESH:"Cerebrospinal Fluid")) regulates deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) decreases a(CHEBI:"amyloid-beta") |
| pmid:30046111 | a(CHEBI:"amyloid-beta") negativeCorrelation act(a(MESH:"Lymphatic Vessels")) |
| pmid:30046111 | a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:30046111 | a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:30046111 | a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29196815 | a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29196815 | a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases path(MESH:"Alzheimer Disease") |
| pmid:19293145 | sec(a(CHEBI:"amyloid-beta")) association path(MESH:"Alzheimer Disease") |
| pmid:19293145 | a(CHEBI:"amyloid-beta") association path(MESH:"Alzheimer Disease") |
| pmid:25514383 | a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:11230871 | a(CHEBI:"amyloid-beta") increases path(MESH:"Alzheimer Disease") |
| pmid:14556719 | a(CHEBI:"amyloid-beta") association path(MESH:"Alzheimer Disease") |
| pmid:30046111 | a(CHEBI:"amyloid-beta") association a(MESH:Macrophages) |
| pmid:30232325 | a(CHEBI:"amyloid-beta") increases bp(HBP:HBP00061) |
| pmid:21214928 | a(CHEBI:"amyloid-beta") increases bp(HBP:HBP00061) |
| pmid:22122372 | a(CHEBI:"amyloid-beta") increases bp(HBP:HBP00061) |
| pmid:22122372 | a(CHEBI:"amyloid-beta") increases bp(HBP:HBP00061) |
| pmid:29196815 | a(CHEBI:"amyloid-beta") increases bp(GO:"positive regulation of neuron apoptotic process") |
| pmid:29196815 | a(CHEBI:"amyloid-beta") increases complex(GO:"neurofibrillary tangle") |
| pmid:29196815 | a(CHEBI:"amyloid-beta") increases path(MESH:Gliosis) |
| pmid:29196815 | a(CHEBI:"amyloid-beta") increases path(MESH:"Neuroaxonal Dystrophies") |
| pmid:18650430 | a(CHEBI:"amyloid-beta") increases bp(GO:"cell adhesion") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") increases path(MESH:"Plaque, Amyloid") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") increases path(MESH:"Plaque, Amyloid") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") increases bp(HBP:HBP00027) |
| pmid:21214928 | a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity") |
| pmid:22122372 | a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity") |
| pmid:22122372 | a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:22122372 | a(CHEBI:"amyloid-beta") increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") increases bp(GO:"neuron death") |
| pmid:22122372 | a(CHEBI:"amyloid-beta") increases bp(GO:"neuron death") |
| pmid:22122372 | a(CHEBI:"amyloid-beta") increases bp(GO:"neuron death") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") association bp(GO:"MAPK cascade") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") association bp(GO:"ERK1 and ERK2 cascade") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") decreases a(MESH:Synapses) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases a(MESH:Synapses) |
| pmid:21214928 | a(CHEBI:"amyloid-beta") decreases bp(GO:memory) |
| pmid:25514383 | a(CHEBI:"amyloid-beta") increases bp(GO:memory) |
| pmid:21214928 | a(CHEBI:"amyloid-beta") association bp(MESH:"Synaptic Transmission") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") decreases bp(GO:"long-term synaptic potentiation") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") association a(MESH:"Potassium Channels") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") increases bp(GO:"cell death") |
| pmid:21214928 | a(CHEBI:"amyloid-beta") association complex(p(HGNC:APBA1), p(HGNC:APP)) |
| pmid:21214928 | sec(a(CHEBI:"amyloid-beta")) association complex(p(HGNC:APBA1), p(HGNC:APP)) |
| pmid:21214928 | a(CHEBI:"amyloid-beta") association complex(p(HGNC:APBA2), p(HGNC:APP)) |
| pmid:21214928 | sec(a(CHEBI:"amyloid-beta")) association complex(p(HGNC:APBA2), p(HGNC:APP)) |
| pmid:21214928 | a(CHEBI:"amyloid-beta") association complex(p(HGNC:APBA3), p(HGNC:APP)) |
| pmid:21214928 | sec(a(CHEBI:"amyloid-beta")) association complex(p(HGNC:APBA3), p(HGNC:APP)) |
| pmid:21214928 | a(CHEBI:"amyloid-beta") association a(CHEBI:"phorbol ester") |
| pmid:22122372 | a(CHEBI:"amyloid-beta") decreases bp(GO:"learning or memory") |
| pmid:22122372 | a(CHEBI:"amyloid-beta") increases a(HBP:HBP00038) |
| pmid:22122372 | a(CHEBI:"amyloid-beta") increases a(HBP:HBP00018) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity) |
| pmid:19293145 | act(a(CHEBI:"amyloid-beta")) increases path(HBP:neurotoxicity) |
| pmid:19293145 | act(a(CHEBI:"amyloid-beta")) increases path(HBP:neurotoxicity) |
| pmid:19293145 | act(a(CHEBI:"amyloid-beta")) increases path(HBP:neurotoxicity) |
| pmid:24590577 | a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity) |
| pmid:21882945 | a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") association bp(GO:"synaptic transmission, cholinergic") |
| pmid:19293145 | a(CHEBI:"amyloid-beta") association bp(GO:"synaptic transmission, cholinergic") |
| pmid:19293145 | a(CHEBI:"amyloid-beta") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19293145 | a(CHEBI:"amyloid-beta") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19293145 | a(CHEBI:"amyloid-beta") association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") positiveCorrelation p(HGNC:CHRNA7) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:CHRNA7)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") association p(HGNC:CHRNA7) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases act(p(HGNC:CHRNA7)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") causesNoChange p(HGNC:CHRNA7) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") causesNoChange act(p(HGNC:CHRNA7)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases p(HGNC:CHRNA7) |
| pmid:17009926 | a(CHEBI:"amyloid-beta") positiveCorrelation p(HGNC:CHRNA7) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") positiveCorrelation p(HGNC:CHRNA4) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases p(HGNC:CHRNA4) |
| pmid:17009926 | a(CHEBI:"amyloid-beta") positiveCorrelation p(HGNC:CHRNA4) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases bp(GO:"intracellular receptor signaling pathway") |
| pmid:19293145 | act(a(CHEBI:"amyloid-beta")) association p(HGNC:FYN) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:FYN)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases act(p(FPLX:PI3K)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases p(HGNC:MAPT, pmod(Ph, Tyr)) |
| pmid:19293145 | act(a(CHEBI:"amyloid-beta")) association bp(GO:"calcium-mediated signaling") |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:MAPK8)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:MAPK14)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") causesNoChange path(HBP:Neurodegeneration) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases bp(MESH:"Neuronal Outgrowth") |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases act(a(CHEBI:carbachol), ma(MESH:Hydrolysis)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases p(HGNC:MAPK1, pmod(Ph)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases p(HGNC:BAX) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:BAX)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases p(HGNC:BCL2) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases act(p(HGNC:BCL2)) |
| pmid:19293145 | act(a(CHEBI:"amyloid-beta")) increases bp(GO:"apoptotic process") |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:26813123 | a(CHEBI:"amyloid-beta") regulates p(HGNC:MAPT, pmod(Ph)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases act(p(FPLX:JNK)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases act(p(FPLX:ERK)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:BAD)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") association bp(GO:"choline transport") |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:CHRNA7, var("p.L250T"))) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") causesNoChange act(complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4))) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases act(complex(p(HGNC:CHRNA2), p(HGNC:CHRNB2))) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2))) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases act(p(HGNC:CHRNA7, var("?"))) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases act(a(CHEBI:nicotine)) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases p(HGNC:CHRNA3) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases p(RGD:Chrna4) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") decreases p(RGD:Chrna7) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases r(RGD:Chrna7) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases p(MGI:Chat) |
| pmid:19293145 | a(CHEBI:"amyloid-beta") increases r(MGI:Chrna3) |
| pmid:17009926 | a(CHEBI:"amyloid-beta") decreases a(CHEBI:acetylcholine) |
| pmid:17009926 | a(CHEBI:"amyloid-beta") decreases sec(a(CHEBI:acetylcholine)) |
| pmid:25514383 | a(CHEBI:"amyloid-beta") increases act(a(CHEBI:acetylcholine)) |
| pmid:17009926 | a(CHEBI:"amyloid-beta") decreases act(p(FPLX:CHRM)) |
| pmid:26813123 | a(CHEBI:"amyloid-beta") increases a(HBP:"amyloid-beta fibrils") |
| pmid:26813123 | act(a(CHEBI:"amyloid-beta")) association act(p(HGNC:CHRM1)) |
| pmid:24590577 | a(CHEBI:"amyloid-beta") decreases act(p(HGNC:CHRM1)) |
| pmid:24590577 | a(CHEBI:"amyloid-beta") decreases complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) |
| pmid:25514383 | a(CHEBI:"amyloid-beta") increases act(a(HBP:"beta-2-containing nAChR")) |
| pmid:25514383 | act(a(CHEBI:"amyloid-beta")) negativeCorrelation a(HBP:"alpha-7 beta-2 nAChR") |
| pmid:25514383 | a(CHEBI:"amyloid-beta") regulates act(p(FPLX:CHRN)) |
| pmid:25514383 | a(CHEBI:"amyloid-beta") decreases act(p(FPLX:CHRN)) |
| pmid:25514383 | a(CHEBI:"amyloid-beta") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:25514383 | a(CHEBI:"amyloid-beta") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:25514383 | a(CHEBI:"amyloid-beta") decreases bp(GO:"neuron cellular homeostasis") |
| pmid:25514383 | a(CHEBI:"amyloid-beta") decreases a(GO:synapse) |
| pmid:14556719 | a(CHEBI:"amyloid-beta") decreases act(complex(GO:"proteasome complex")) |
| pmid:25784053 | a(CHEBI:"amyloid-beta") decreases act(p(FPLX:Proteasome)) |
| pmid:24027553 | a(CHEBI:"amyloid-beta") increases p(HGNC:MAPT, frag("?", "17kD")) |
| pmid:24027553 | a(CHEBI:"amyloid-beta") increases p(HGNC:MAPT, frag("?", "35kD")) |
| pmid:24027553 | a(CHEBI:"amyloid-beta") increases p(HGNC:MAPT, frag("?", "24kD")) |
| pmid:30126037 | a(CHEBI:"amyloid-beta") causesNoChange p(MGI:Cdkn2a) |
| pmid:26195256 | a(CHEBI:"amyloid-beta") association a(MESH:Insulin) |
| pmid:26195256 | a(CHEBI:"amyloid-beta") association bp(HBP:"perivascular drainage pathways") |
| pmid:29626319 | a(CHEBI:"amyloid-beta") increases bp(GO:"response to oxidative stress") |
| pmid:29626319 | a(CHEBI:"amyloid-beta") increases bp(HBP:"mitochondrial dysfunction") |
| pmid:29626319 | a(CHEBI:"amyloid-beta") positiveCorrelation bp(GO:aging) |
| pmid:29626319 | a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Diabetes Mellitus") |
| pmid:29626319 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:MMP2)) |
| pmid:29626319 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:MMP3)) |
| pmid:29626319 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:MMP9)) |
| pmid:29626319 | a(CHEBI:"amyloid-beta") decreases a(MESH:"Cerebrospinal Fluid") |
| pmid:29626319 | deg(a(CHEBI:"amyloid-beta")) association p(HGNC:AQP4) |
| pmid:19251756 | a(CHEBI:"amyloid-beta") positiveCorrelation complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) |
| pmid:16566606 | a(CHEBI:"amyloid-beta") increases bp(GO:"inflammatory response") |
| pmid:29221819 | a(CHEBI:"amyloid-beta") negativeCorrelation p(MGI:Dyrk1a) |
| pmid:25331948 | a(CHEBI:"amyloid-beta") positiveCorrelation p(MGI:Syk) |
| pmid:26118667 | a(CHEBI:"amyloid-beta") negativeCorrelation m(MIRBASE:"rno-mir-195") |
| pmid:26118667 | a(CHEBI:"amyloid-beta") increases p(INTERPRO:"Peptidase C2, calpain, catalytic domain") |
| pmid:22156579 | a(CHEBI:"amyloid-beta") increases p(HGNC:MARK4) |
| pmid:22156579 | a(CHEBI:"amyloid-beta") positiveCorrelation a(HBP:"Tau epitope, PHF1") |
| pmid:24401760 | a(CHEBI:"amyloid-beta") positiveCorrelation p(MGI:Bace1) |
| pmid:28855586 | act(a(CHEBI:"amyloid-beta")) negativeCorrelation composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) |
| pmid:25378699 | a(CHEBI:"amyloid-beta") increases p(RGD:Mapt, pmod(Sumo)) |
| pmid:28500862 | a(CHEBI:"amyloid-beta") positiveCorrelation p(HBP:"Tau aggregates") |
| pmid:28019679 | a(CHEBI:"amyloid-beta") increases bp(GO:"innate immune response") |
| pmid:28019679 | a(CHEBI:"amyloid-beta") increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:23702978 | a(CHEBI:"amyloid-beta") increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:28019679 | a(CHEBI:"amyloid-beta") increases a(CHEBI:"nitric oxide") |
| pmid:28019679 | a(CHEBI:"amyloid-beta") increases sec(p(HGNC:TNF)) |
| pmid:28019679 | a(CHEBI:"amyloid-beta") increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pmid:28019679 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:CASP1)) |
| pmid:23702978 | a(CHEBI:"amyloid-beta") increases act(p(HGNC:NLRP3)) |
| pmid:27314526 | a(CHEBI:"amyloid-beta") association p(HGNC:NLRP3) |
| pmid:23702978 | a(CHEBI:"amyloid-beta") increases act(p(FPLX:TLR)) |
| pmid:24561250 | a(CHEBI:"amyloid-beta") increases act(complex(GO:"inflammasome complex")) |
| pmid:24561250 | a(CHEBI:"amyloid-beta") increases bp(GO:phagocytosis) |
| pmid:24561250 | a(CHEBI:"amyloid-beta") decreases a(GO:lysosome) |
| pmid:30046111 | bp(GO:phagocytosis) regulates deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | bp(GO:phagocytosis) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | bp(GO:phagocytosis) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | bp(GO:phagocytosis) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | bp(GO:phagocytosis) association p(HGNC:TREM2) |
| pmid:29626319 | bp(GO:phagocytosis) association p(HGNC:ABCA7) |
| pmid:29626319 | bp(GO:phagocytosis) association p(HGNC:CD33) |
| pmid:29626319 | bp(GO:phagocytosis) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pmid:29626319 | bp(GO:phagocytosis) decreases p(HGNC:MAPT) |
| pmid:24561250 | bp(GO:phagocytosis) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:30046111 | a(MESH:Microglia) regulates deg(a(CHEBI:"amyloid-beta")) |
| pmid:26195256 | a(MESH:Microglia) decreases a(CHEBI:"amyloid-beta", loc(MESH:"Extracellular Fluid")) |
| pmid:23178521 | a(MESH:Microglia) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:23383175 | a(MESH:Microglia) positiveCorrelation a(MESH:Astrocytes) |
| pmid:23383175 | a(MESH:Microglia) negativeCorrelation a(GO:"myelin sheath") |
| pmid:29202785 | act(a(MESH:Microglia)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) |
| pmid:29202785 | act(a(MESH:Microglia)) positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:29202785 | act(a(MESH:Microglia)) positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:29626319 | a(MESH:Microglia) increases bp(GO:"immune response") |
| pmid:29626319 | act(a(MESH:Microglia)) increases bp(GO:"cytokine production involved in inflammatory response") |
| pmid:29626319 | act(a(MESH:Microglia)) increases bp(GO:"inflammatory response") |
| pmid:29626319 | act(a(MESH:Microglia)) increases bp(HBP:Neurodegeneration) |
| pmid:29626319 | act(a(MESH:Microglia)) increases bp(GO:phagocytosis) |
| pmid:29626319 | a(MESH:Microglia) increases bp(GO:phagocytosis) |
| pmid:29238289 | a(MESH:Microglia) increases p(HGNC:MAPT) |
| pmid:27314526 | a(MESH:Microglia) increases p(HGNC:NLRP3) |
| pmid:27314526 | a(MESH:Microglia) increases p(HGNC:P2RX7) |
| pmid:27314526 | a(MESH:Microglia) increases p(HGNC:TLR4) |
| pmid:30046111 | a(MESH:Monocytes) regulates deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(MESH:Monocytes) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(MESH:Monocytes) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:30046111 | a(MESH:Macrophages) regulates deg(a(CHEBI:"amyloid-beta")) |
| pmid:30046111 | a(MESH:Macrophages) association a(CHEBI:"amyloid-beta") |
| pmid:30046111 | a(HBP:HBP00018) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21718217 | a(HBP:HBP00018) association path(MESH:"Alzheimer Disease") |
| pmid:30046111 | a(HBP:HBP00018) decreases bp(GO:"neuron cellular homeostasis") |
| pmid:30046111 | a(HBP:HBP00018) increases path(MESH:"Problem Behavior") |
| pmid:29196815 | a(HBP:HBP00018) causesNoChange bp(GO:"neuron death") |
| pmid:29196815 | a(HBP:HBP00018) causesNoChange bp(GO:"astrocyte activation") |
| pmid:22122372 | a(HBP:HBP00018) association a(MESH:"Amyloid beta-Peptides") |
| pmid:22122372 | a(HBP:HBP00018) increases path(MESH:"Plaque, Amyloid") |
| pmid:30046111 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00018) |
| pmid:21718217 | path(MESH:"Alzheimer Disease") association a(HBP:HBP00018) |
| pmid:22040696 | path(MESH:"Alzheimer Disease") increases a(HBP:HBP00018) |
| pmid:30046111 | path(MESH:"Alzheimer Disease") association act(a(MESH:"Lymphatic Vessels")) |
| pmid:30046111 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:30046111 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:30046111 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association sec(a(CHEBI:"amyloid-beta")) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association a(CHEBI:"amyloid-beta") |
| pmid:25514383 | path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:14556719 | path(MESH:"Alzheimer Disease") association a(CHEBI:"amyloid-beta") |
| pmid:29626319 | path(MESH:"Alzheimer Disease") decreases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | path(MESH:"Alzheimer Disease") increases a(CHEBI:"amyloid-beta") |
| pmid:10656250 | path(MESH:"Alzheimer Disease") increases p(HGNC:BACE1) |
| pmid:26837465 | path(MESH:"Alzheimer Disease") increases complex(p(HGNC:ESR1), p(HGNC:MAPT)) |
| pmid:29196815 | path(MESH:"Alzheimer Disease") isA path(MESH:"Neurodegenerative Diseases") |
| pmid:24511233 | path(MESH:"Alzheimer Disease") isA path(MESH:"Neurodegenerative Diseases") |
| pmid:24590577 | path(MESH:"Alzheimer Disease") isA path(MESH:"Neurodegenerative Diseases") |
| pmid:29196815 | path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) |
| pmid:19126755 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:cognition) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) |
| pmid:24511233 | path(MESH:"Alzheimer Disease") association bp(GO:cognition) |
| pmid:24511233 | path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) |
| pmid:24590577 | path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:cognition) |
| pmid:19721446 | path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) |
| pmid:29196815 | path(MESH:"Alzheimer Disease") increases bp(GO:"positive regulation of neuron apoptotic process") |
| pmid:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pmid:19126755 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association path(MESH:"Plaque, Amyloid") |
| pmid:24590577 | path(MESH:"Alzheimer Disease") association path(MESH:"Plaque, Amyloid") |
| pmid:25514383 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pmid:19721446 | path(MESH:"Alzheimer Disease") increases path(MESH:"Plaque, Amyloid") |
| pmid:14556719 | path(MESH:"Alzheimer Disease") increases path(MESH:"Plaque, Amyloid") |
| pmid:22817713 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pmid:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:"Amyloid beta-Peptides") |
| pmid:22122372 | path(MESH:"Alzheimer Disease") association a(MESH:"Amyloid beta-Peptides") |
| pmid:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:28420982 | path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:22817713 | path(MESH:"Alzheimer Disease") association a(GO:"neurofibrillary tangle") |
| pmid:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00074) |
| pmid:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00074) |
| pmid:29196815 | path(MESH:"Alzheimer Disease") negativeCorrelation a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00076) |
| pmid:29196815 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:NGFR) |
| pmid:21214928 | path(MESH:"Alzheimer Disease") positiveCorrelation r(HBP:HBP00064) |
| pmid:21214928 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:HBP00065) |
| pmid:21214928 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:ADAM10) |
| pmid:21214928 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:ADAM10)) |
| pmid:21214928 | path(MESH:"Alzheimer Disease") negativeCorrelation a(HBP:HBP00067) |
| pmid:22122372 | path(MESH:"Alzheimer Disease") association bp(GO:"neurofibrillary tangle assembly") |
| pmid:22122372 | path(MESH:"Alzheimer Disease") association bp(GO:"neuron death") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") increases bp(GO:"neuron death") |
| pmid:17009926 | path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death") |
| pmid:17009926 | path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death") |
| pmid:24590577 | path(MESH:"Alzheimer Disease") increases bp(GO:"neuron death") |
| pmid:25514383 | path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death") |
| pmid:22040696 | path(MESH:"Alzheimer Disease") increases bp(GO:"neuron death") |
| pmid:28420982 | path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death") |
| pmid:22122372 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00064) |
| pmid:22122372 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00065) |
| pmid:19126755 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19126755 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19721446 | path(MESH:"Alzheimer Disease") decreases p(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19126755 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:24590577 | path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19721446 | path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA7) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association p(HGNC:CHRNA7) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA7) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") increases p(HGNC:CHRNA7) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA7) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA7) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA7) |
| pmid:22040696 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA7) |
| pmid:19126755 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Dementia) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association path(MESH:Dementia) |
| pmid:24511233 | path(MESH:"Alzheimer Disease") association path(MESH:Dementia) |
| pmid:25514383 | path(MESH:"Alzheimer Disease") association path(MESH:Dementia) |
| pmid:21718217 | path(MESH:"Alzheimer Disease") increases path(MESH:Dementia) |
| pmid:14556719 | path(MESH:"Alzheimer Disease") increases path(MESH:Dementia) |
| pmid:19126755 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"synaptic transmission, cholinergic") |
| pmid:24511233 | path(MESH:"Alzheimer Disease") decreases bp(GO:"synaptic transmission, cholinergic") |
| pmid:24511233 | path(MESH:"Alzheimer Disease") decreases bp(GO:"synaptic transmission, cholinergic") |
| pmid:26813123 | path(MESH:"Alzheimer Disease") association bp(GO:"synaptic transmission, cholinergic") |
| pmid:24590577 | path(MESH:"Alzheimer Disease") decreases bp(GO:"synaptic transmission, cholinergic") |
| pmid:19126755 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Neurofibrillary Tangles") |
| pmid:24590577 | path(MESH:"Alzheimer Disease") association path(MESH:"Neurofibrillary Tangles") |
| pmid:24027553 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Neurofibrillary Tangles") |
| pmid:19126755 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Neurogenic Inflammation") |
| pmid:19126755 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA4) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA4) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA4) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA4) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA4) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases bp(GO:memory) |
| pmid:24511233 | path(MESH:"Alzheimer Disease") association bp(GO:memory) |
| pmid:22040696 | path(MESH:"Alzheimer Disease") decreases bp(GO:memory) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases path(MESH:"Psychomotor Performance") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association path(MESH:Death) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:"Neurofibrillary Tangles") |
| pmid:14556719 | path(MESH:"Alzheimer Disease") increases a(MESH:"Neurofibrillary Tangles") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association a(HBP:"amyloid-beta aggregates") |
| pmid:25514383 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"amyloid-beta aggregates") |
| pmid:22817713 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"amyloid-beta aggregates") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") increases p(HGNC:BCHE) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases a(CHEBI:acetylcholine) |
| pmid:25514383 | path(MESH:"Alzheimer Disease") decreases a(CHEBI:acetylcholine) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT)) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT)) |
| pmid:26813123 | path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT)) |
| pmid:24590577 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHAT) |
| pmid:25514383 | path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT)) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases act(a(MESH:"Cholinesterase Inhibitors")) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association g(HGNC:CHAT) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association g(HGNC:ACHE) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association a(HBP:"alpha-4 beta-2 nAChR") |
| pmid:11230871 | path(MESH:"Alzheimer Disease") decreases a(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") increases p(HGNC:FYN) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") increases p(HGNC:FYN) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") increases complex(p(HGNC:FYN), p(HGNC:MAPT)) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association act(p(HGNC:INS)) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association bp(GO:"regulation of cytosolic calcium ion concentration") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association p(HGNC:PSEN1) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association bp(GO:learning) |
| pmid:24511233 | path(MESH:"Alzheimer Disease") association bp(GO:learning) |
| pmid:24511233 | path(MESH:"Alzheimer Disease") decreases bp(GO:learning) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") association path(MESH:"Cognitive Dysfunction") |
| pmid:24511233 | path(MESH:"Alzheimer Disease") association path(MESH:"Cognitive Dysfunction") |
| pmid:24511233 | path(MESH:"Alzheimer Disease") association path(MESH:"Cognitive Dysfunction") |
| pmid:26813123 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pmid:27522251 | path(MESH:"Alzheimer Disease") increases path(MESH:"Cognitive Dysfunction") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:APOE) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") |
| pmid:24511233 | path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") |
| pmid:26813123 | path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"Cholinergic Neurons") |
| pmid:24590577 | path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") |
| pmid:24590577 | path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA3) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA3) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA3) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA3) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA3) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") causesNoChange r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNB4) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor AMPA type subunits") |
| pmid:19293145 | path(MESH:"Alzheimer Disease") decreases p(HGNC:GABRB3) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") causesNoChange p(MGI:Chrna7) |
| pmid:25881725 | path(MESH:"Alzheimer Disease") negativeCorrelation p(MGI:Chrna7) |
| pmid:19293145 | path(MESH:"Alzheimer Disease") causesNoChange p(MGI:Chrna4) |
| pmid:24511233 | path(MESH:"Alzheimer Disease") association path(MESH:"Psychotic Disorders") |
| pmid:24511233 | path(MESH:"Alzheimer Disease") association path(MESH:"Psychotic Disorders") |
| pmid:24511233 | path(MESH:"Alzheimer Disease") association path(MESH:"Psychotic Disorders") |
| pmid:24511233 | path(MESH:"Alzheimer Disease") increases path(MESH:Depression) |
| pmid:26813123 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Depression) |
| pmid:24511233 | path(MESH:"Alzheimer Disease") increases path(MESH:Anxiety) |
| pmid:24511233 | path(MESH:"Alzheimer Disease") association bp(MESH:Aging) |
| pmid:17009926 | path(MESH:"Alzheimer Disease") association p(FPLX:CHRN) |
| pmid:17009926 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(FPLX:CHRN)) |
| pmid:17009926 | path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:CHRN) |
| pmid:17009926 | path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:CHRN) |
| pmid:25514383 | path(MESH:"Alzheimer Disease") decreases p(FPLX:CHRN) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") association p(FPLX:CHRN) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:CHRN) |
| pmid:17009926 | path(MESH:"Alzheimer Disease") association complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) |
| pmid:26813123 | path(MESH:"Alzheimer Disease") increases deg(a(MESH:"Basal Nucleus of Meynert")) |
| pmid:26813123 | path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"Basal Nucleus of Meynert") |
| pmid:26813123 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Apathy) |
| pmid:26813123 | path(MESH:"Alzheimer Disease") association p(HGNC:ACHE) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") decreases act(p(HGNC:ACHE)) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:ACHE)) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") decreases act(p(HGNC:ACHE)) |
| pmid:26813123 | path(MESH:"Alzheimer Disease") negativeCorrelation a(CHEBI:rivastigmine) |
| pmid:26813123 | path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) |
| pmid:24590577 | path(MESH:"Alzheimer Disease") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pmid:19721446 | path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pmid:25514383 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) |
| pmid:14556719 | path(MESH:"Alzheimer Disease") association p(HGNC:MAPT) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") association p(HGNC:MAPT) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") association p(HGNC:MAPT) |
| pmid:27574109 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) |
| pmid:27574109 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) |
| pmid:30126037 | path(MESH:"Alzheimer Disease") association p(HGNC:MAPT) |
| pmid:22419736 | path(MESH:"Alzheimer Disease") causesNoChange p(HGNC:MAPT) |
| pmid:28420982 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) |
| pmid:28420982 | path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT) |
| pmid:28420982 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) |
| pmid:25514383 | path(MESH:"Alzheimer Disease") negativeCorrelation a(GO:synapse) |
| pmid:25514383 | path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"White Matter") |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association a(MESH:"White Matter") |
| pmid:25514383 | path(MESH:"Alzheimer Disease") negativeCorrelation a(HP:"cholinergic neuron") |
| pmid:25514383 | path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:acetylcholine), p(FPLX:CHRN)) |
| pmid:25514383 | path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:acetylcholine), p(FPLX:CHRM)) |
| pmid:25514383 | path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:nicotine), p(FPLX:CHRN)) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:nicotine), p(FPLX:CHRN)) |
| pmid:25514383 | path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:nicotine), p(FPLX:CHRM)) |
| pmid:25514383 | path(MESH:"Alzheimer Disease") decreases p(FPLX:CHRM) |
| pmid:25514383 | path(MESH:"Alzheimer Disease") positiveCorrelation complex(p(HGNC:CHRNA7), p(HGNC:FLNA)) |
| pmid:21718217 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00030) |
| pmid:21718217 | path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:ARG1) |
| pmid:21718217 | path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:CHI3L1) |
| pmid:21718217 | path(MESH:"Alzheimer Disease") association p(HBP:HBP00030) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation a(HBP:"alpha-4-containing nAChR") |
| pmid:11230871 | path(MESH:"Alzheimer Disease") negativeCorrelation a(HBP:"alpha-7-containing nAChR") |
| pmid:11230871 | path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:CHRNA7) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:CHRNA3) |
| pmid:11230871 | path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:CHRNA4) |
| pmid:19721446 | path(MESH:"Alzheimer Disease") decreases a(MESH:Neurons) |
| pmid:19721446 | path(MESH:"Alzheimer Disease") decreases path(MESH:"Memory, Episodic") |
| pmid:21787755 | path(MESH:"Alzheimer Disease") association a(HBP:AβOs) |
| pmid:28901280 | path(MESH:"Alzheimer Disease") association p(MESH:"Receptors, Nicotinic") |
| pmid:23178521 | path(MESH:"Alzheimer Disease") increases p(MGI:Il6) |
| pmid:23178521 | path(MESH:"Alzheimer Disease") increases p(MGI:Tnf) |
| pmid:23178521 | path(MESH:"Alzheimer Disease") increases p(MGI:Stat3, pmod(Ph)) |
| pmid:25437566 | path(MESH:"Alzheimer Disease") decreases p(HGNC:HSP90AB1) |
| pmid:25437566 | path(MESH:"Alzheimer Disease") decreases p(HGNC:HSPA8) |
| pmid:25437566 | path(MESH:"Alzheimer Disease") decreases p(HGNC:HSPA14) |
| pmid:25437566 | path(MESH:"Alzheimer Disease") decreases p(HGNC:TCP1) |
| pmid:14556719 | path(MESH:"Alzheimer Disease") decreases bp(GO:"short-term memory") |
| pmid:14556719 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:UBA1)) |
| pmid:14556719 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:UBA2)) |
| pmid:14556719 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:29626319 | path(MESH:"Alzheimer Disease") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:25784053 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(FPLX:Proteasome)) |
| pmid:25784053 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy) |
| pmid:8282104 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") regulates p(HGNC:MAPT, pmod(Ph)) |
| pmid:29311797 | path(MESH:"Alzheimer Disease") association p(HGNC:MAPT, pmod(Ph)) |
| pmid:26458742 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:27373205 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:22817713 | path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:8282104 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CDK5) |
| pmid:8282104 | path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:ERK) |
| pmid:8282104 | path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:GSK3) |
| pmid:30116051 | path(MESH:"Alzheimer Disease") decreases p(HGNC:SIRT1) |
| pmid:29540553 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:SIRT1)) |
| pmid:30116051 | path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:PSEN1, var("?")) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association g(HGNC:PSEN1, var("?")) |
| pmid:30116051 | path(MESH:"Alzheimer Disease") negativeCorrelation a(CHEBI:"selenium(2+)") |
| pmid:30116051 | path(MESH:"Alzheimer Disease") increases act(p(HGNC:ABL1)) |
| pmid:30116051 | path(MESH:"Alzheimer Disease") decreases p(HGNC:IDE) |
| pmid:30116051 | path(MESH:"Alzheimer Disease") decreases p(HGNC:MME) |
| pmid:29024336 | path(MESH:"Alzheimer Disease") increases path(MESH:"Proteostasis Deficiencies") |
| pmid:29215007 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("?")) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") association p(HGNC:PIN1) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") increases a(CHEBI:Thrombin, loc(MESH:Microvessels)) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") increases a(CHEBI:Thrombin, loc(MESH:"Cerebrospinal Fluid")) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") association bp(HBP:"APP processing") |
| pmid:24027553 | path(MESH:"Alzheimer Disease") increases act(p(HGNC:CAPN2)) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") positiveCorrelation act(p(HGNC:CASP3)) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") positiveCorrelation act(p(HGNC:CASP6)) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Inflammation) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"proteasomal protein catabolic process") |
| pmid:24027553 | path(MESH:"Alzheimer Disease") increases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Proteasome)) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") positiveCorrelation bp(MESH:Autophagy) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") decreases bp(MESH:Autophagy) |
| pmid:24027553 | path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:Lysosomes) |
| pmid:27574109 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"3R tau") |
| pmid:27574109 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"4R tau") |
| pmid:27574109 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:27574109 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:28420982 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:22817713 | path(MESH:"Alzheimer Disease") increases a(HBP:"Tau oligomers") |
| pmid:27574109 | path(MESH:"Alzheimer Disease") positiveCorrelation composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) |
| pmid:17403556 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17403556 | path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:22253473 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17403556 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:21734277 | path(MESH:"Alzheimer Disease") association act(p(HBP:"6D tau", frag("2_18"))) |
| pmid:21734277 | path(MESH:"Alzheimer Disease") association act(p(HBP:"6D tau", frag("2_18"))) |
| pmid:23528736 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:UBB) |
| pmid:23528736 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:UBC) |
| pmid:23528736 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:UBA52) |
| pmid:23528736 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RPS27A) |
| pmid:23528736 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"UBB+1") |
| pmid:23528736 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNCGENEFAMILY:"Ubiquitin like modifier activating enzymes") |
| pmid:23528736 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNCGENEFAMILY:"Ubiquitin conjugating enzymes E2") |
| pmid:23528736 | path(MESH:"Alzheimer Disease") association p(HGNC:UCHL1, var("?")) |
| pmid:23528736 | path(MESH:"Alzheimer Disease") decreases bp(MESH:Proteolysis) |
| pmid:23528736 | path(MESH:"Alzheimer Disease") increases a(MESH:Autophagosomes) |
| pmid:23528736 | path(MESH:"Alzheimer Disease") increases a(GO:autolysosome) |
| pmid:23528736 | path(MESH:"Alzheimer Disease") decreases bp(GO:"lysosomal protein catabolic process") |
| pmid:21882945 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:21882945 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) |
| pmid:21882945 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:BAG1) |
| pmid:30126037 | path(MESH:"Alzheimer Disease") association bp(MESH:"Cerebrovascular Circulation") |
| pmid:22419736 | path(MESH:"Alzheimer Disease") increases p(HGNC:AK1) |
| pmid:22419736 | path(MESH:"Alzheimer Disease") increases p(HGNC:AK1) |
| pmid:22419736 | path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:28420982 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:26458742 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:22419736 | path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:26458742 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:22419736 | path(MESH:"Alzheimer Disease") decreases p(ECCODE:"2.7.11.31", pmod(Ph, Thr, 172)) |
| pmid:28420982 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:29311797 | path(MESH:"Alzheimer Disease") isA path(MESH:Tauopathies) |
| pmid:29311797 | path(MESH:"Alzheimer Disease") decreases p(HGNC:PPID) |
| pmid:29311797 | path(MESH:"Alzheimer Disease") increases p(HGNC:FKBP5) |
| pmid:29311797 | path(MESH:"Alzheimer Disease") decreases p(HGNC:FKBP4) |
| pmid:29311797 | path(MESH:"Alzheimer Disease") decreases act(p(HGNC:PPP5C)) |
| pmid:29311797 | path(MESH:"Alzheimer Disease") association p(HGNC:STUB1) |
| pmid:29311797 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:AHSA1) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 68)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 69)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 71)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 113)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 123)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 153)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 175)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 184)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 185)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 191)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 197)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 208)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 210)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 214)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 237)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 238)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 258)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 289)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 394)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 403)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 409)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 435)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 427)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 433)) |
| pmid:26751493 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:26458742 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") increases p(HGNC:APP) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association g(HGNC:PSEN2, var("?")) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association g(HGNC:APP, var("?")) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association path(MESH:Aging) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association p(HBP:"APOE e4") |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association p(HGNC:TREM2) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association p(HGNC:CLU) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association p(HGNC:PICALM) |
| pmid:29626319 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PICALM) |
| pmid:27260836 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PICALM) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association path(MESH:"Cardiovascular Diseases") |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association path(MESH:"Diabetes Mellitus") |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association path(MESH:Hypertension) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association path(MESH:"Craniocerebral Trauma") |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association path(MESH:"Sleep Initiation and Maintenance Disorders") |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association path(MESH:"Pick Disease of the Brain") |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association a(MESH:"Prefrontal Cortex") |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association a(MESH:"Cerebral Cortex") |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association a(MESH:"Cerebral Ventricles") |
| pmid:26195256 | path(MESH:"Alzheimer Disease") decreases bp(GO:"glucose metabolic process") |
| pmid:26195256 | path(MESH:"Alzheimer Disease") decreases a(MESH:Brain) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") association a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:26195256 | path(MESH:"Alzheimer Disease") decreases p(MESH:Neprilysin) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") increases p(HGNC:MMP2) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") decreases p(HGNC:LRP1) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") decreases p(HGNC:ABCB1) |
| pmid:29626319 | path(MESH:"Alzheimer Disease") decreases p(HGNC:ABCB1) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") increases p(HGNC:AGER) |
| pmid:26195256 | path(MESH:"Alzheimer Disease") increases path(MESH:"Calcification, Physiologic") |
| pmid:26195256 | path(MESH:"Alzheimer Disease") increases path(MESH:Fibrosis) |
| pmid:27373205 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau aggregates") |
| pmid:22817713 | path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau aggregates") |
| pmid:22817713 | path(MESH:"Alzheimer Disease") association a(MESH:"Neuropil Threads") |
| pmid:29626319 | path(MESH:"Alzheimer Disease") decreases bp(GO:"lysosomal microautophagy") |
| pmid:29626319 | path(MESH:"Alzheimer Disease") positiveCorrelation act(p(HGNC:ACE)) |
| pmid:29626319 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:SERPINF2) |
| pmid:29626319 | path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:SERPINF2)) |
| pmid:29626319 | path(MESH:"Alzheimer Disease") decreases tloc(a(CHEBI:water), fromLoc(GO:"extracellular region"), toLoc(MESH:"Cerebrospinal Fluid")) |
| pmid:25974414 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp13*")) |
| pmid:25974414 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp25*")) |
| pmid:25974414 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp368*")) |
| pmid:25974414 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Glu391*")) |
| pmid:25974414 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp421*")) |
| pmid:23531502 | path(MESH:"Alzheimer Disease") positiveCorrelation act(a(CHEBI:acrolein)) |
| pmid:19251756 | path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"canonical glycolysis") |
| pmid:19251756 | path(MESH:"Alzheimer Disease") positiveCorrelation p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) |
| pmid:19251756 | path(MESH:"Alzheimer Disease") positiveCorrelation p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) |
| pmid:11738469 | path(MESH:"Alzheimer Disease") positiveCorrelation act(p(ECCODE:"2.3.2.13")) |
| pmid:8985134 | path(MESH:"Alzheimer Disease") positiveCorrelation act(p(ECCODE:"2.3.2.13")) |
| pmid:9099822 | path(MESH:"Alzheimer Disease") increases act(p(HGNC:TGM2)) |
| pmid:17050703 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) |
| pmid:20096481 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs2651206) |
| pmid:21548880 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs2651206) |
| pmid:20096481 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs10807287) |
| pmid:20096481 | path(MESH:"Alzheimer Disease") association g(DBSNP:rs7764257) |
| pmid:23666762 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MARK4) |
| pmid:26118667 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"CDK5R1 p25") |
| pmid:21910444 | path(MESH:"Alzheimer Disease") increases p(HGNC:MAPK1) |
| pmid:21910444 | path(MESH:"Alzheimer Disease") increases p(HGNC:PRKCB) |
| pmid:24401760 | path(MESH:"Alzheimer Disease") increases p(HGNC:ITPKB) |
| pmid:29540553 | path(MESH:"Alzheimer Disease") negativeCorrelation p(MGI:Sirt1) |
| pmid:29540553 | path(MESH:"Alzheimer Disease") negativeCorrelation p(MGI:Sirt3) |
| pmid:29276758 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) |
| pmid:21427723 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) |
| pmid:21427723 | path(MESH:"Alzheimer Disease") isA path(HBP:"4R tauopathy") |
| pmid:19732809 | path(MESH:"Alzheimer Disease") negativeCorrelation a(HBP:"O-GlcNAcylation") |
| pmid:27716675 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SUMO1) |
| pmid:19765634 | path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs761059) |
| pmid:29281045 | path(MESH:"Alzheimer Disease") decreases p(HGNC:LCMT1) |
| pmid:29281045 | path(MESH:"Alzheimer Disease") increases p(ECCODE:"3.1.1.89") |
| pmid:23157676 | path(MESH:"Alzheimer Disease") negativeCorrelation p(HBP:"cis p-tau") |
| pmid:24561250 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) |
| pmid:27314526 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) |
| pmid:24561250 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL18) |
| pmid:27314526 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL18) |
| pmid:27314526 | path(MESH:"Alzheimer Disease") association p(HGNC:IL18) |
| pmid:24561250 | path(MESH:"Alzheimer Disease") association complex(GO:"NLRP3 inflammasome complex") |
| pmid:24561250 | path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:aging) |
| pmid:24561250 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PYCARD) |
| pmid:24561250 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:NLRC4) |
| pmid:24561250 | path(MESH:"Alzheimer Disease") association complex(GO:"IPAF inflammasome complex") |
| pmid:27314526 | path(MESH:"Alzheimer Disease") association complex(GO:"inflammasome complex") |
| pmid:27314526 | path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:P2RX7) |
| pmid:25514383 | bp(GO:"neuron cellular homeostasis") association complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) |
| pmid:30046111 | bp(GO:aging) decreases bp(GO:"cerebrospinal fluid circulation") |
| pmid:30046111 | bp(GO:aging) decreases act(a(HP:"interstitial fluid")) |
| pmid:30046111 | bp(GO:aging) increases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | bp(GO:aging) positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:30046111 | bp(GO:aging) decreases act(a(MESH:"Lymphatic Vessels")) |
| pmid:30046111 | bp(GO:aging) negativeCorrelation act(a(MESH:"Lymphatic Vessels")) |
| pmid:30046111 | bp(GO:aging) decreases tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) |
| pmid:30046111 | bp(GO:aging) association bp(GO:"immune response") |
| pmid:30046111 | bp(GO:aging) association bp(GO:"inflammatory response") |
| pmid:30046111 | bp(GO:aging) association bp(GO:"phospholipid metabolic process") |
| pmid:30046111 | bp(GO:aging) association bp(GO:"extracellular matrix organization") |
| pmid:30046111 | bp(GO:aging) association bp(GO:"cell adhesion") |
| pmid:30046111 | bp(GO:aging) association bp(GO:"endothelial tube morphogenesis") |
| pmid:30046111 | bp(GO:aging) decreases p(MGI:Cdk5r1) |
| pmid:30046111 | bp(GO:aging) decreases p(MGI:Adamts3) |
| pmid:30046111 | bp(GO:aging) decreases p(MGI:Fgfr3) |
| pmid:29196815 | bp(GO:aging) increases path(MESH:"Alzheimer Disease") |
| pmid:24561250 | bp(GO:aging) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29196815 | bp(GO:aging) increases a(HBP:HBP00074) |
| pmid:25514383 | bp(GO:aging) association path(MESH:Dementia) |
| pmid:27522251 | bp(GO:aging) association p(MGI:Chrna7) |
| pmid:11230871 | bp(GO:aging) negativeCorrelation complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) |
| pmid:11230871 | bp(GO:aging) negativeCorrelation complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) |
| pmid:11230871 | bp(GO:aging) causesNoChange r(HGNC:CHRNA3) |
| pmid:11230871 | bp(GO:aging) negativeCorrelation a(HBP:"alpha-4-containing nAChR") |
| pmid:11230871 | bp(GO:aging) negativeCorrelation a(HBP:"alpha-7-containing nAChR") |
| pmid:14556719 | bp(GO:aging) negativeCorrelation act(complex(GO:"proteasome complex")) |
| pmid:14556719 | bp(GO:aging) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:14556719 | bp(GO:aging) increases p(HGNC:PRNP) |
| pmid:30116051 | bp(GO:aging) decreases act(p(HGNC:SIRT1)) |
| pmid:30116051 | bp(GO:aging) decreases a(CHEBI:"NAD(+)") |
| pmid:29024336 | bp(GO:aging) increases path(MESH:"Proteostasis Deficiencies") |
| pmid:29024336 | bp(GO:aging) increases path(MESH:"Proteostasis Deficiencies") |
| pmid:21882945 | bp(GO:aging) negativeCorrelation deg(p(HGNC:MAPT)) |
| pmid:21882945 | bp(GO:aging) positiveCorrelation p(HGNC:FKBP5) |
| pmid:29626319 | bp(GO:aging) negativeCorrelation p(HGNC:IDE) |
| pmid:25681682 | bp(GO:aging) negativeCorrelation p(HGNC:AGER) |
| pmid:29421605 | bp(GO:aging) increases p(RGD:Ptpn1) |
| pmid:24561250 | bp(GO:aging) increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pmid:24561250 | bp(GO:aging) increases p(HGNC:IL1B) |
| pmid:24561250 | bp(GO:aging) increases p(HGNC:IL18) |
| pmid:30046111 | bp(GO:"cerebrospinal fluid circulation") decreases a(CHEBI:"amyloid-beta") |
| pmid:30046111 | act(a(HP:"interstitial fluid")) decreases a(CHEBI:"amyloid-beta") |
| pmid:30046111 | a(MESH:"Lymphatic Vessels") regulates bp(MESH:Homeostasis) |
| pmid:30046111 | a(MESH:"Lymphatic Vessels") increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymph Nodes")) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) association tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Parenchymal Tissue"), toLoc(MESH:"Lymph Nodes")) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:macromolecule), fromLoc(HP:"interstitial fluid"), toLoc(MESH:"Lymph Nodes")) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Parenchymal Tissue")) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases bp(MESH:"Cerebrovascular Circulation") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases bp(MESH:"Cerebrovascular Circulation") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) association bp(MESH:"Cerebrovascular Circulation") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) positiveCorrelation bp(MESH:"Cerebrovascular Circulation") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases bp(GO:"cerebrospinal fluid secretion") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:"gadolinium atom"), fromLoc(GO:"extracellular space"), toLoc(MESH:"Cerebrospinal Fluid")) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases bp(GO:"fear response") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases path(MESH:"Spatial Learning") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases path(MESH:"Spatial Learning") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases bp(GO:memory) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases bp(GO:memory) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) association bp(GO:"gene expression") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) association path(MESH:"Huntington Disease") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) association path(MESH:"Parkinson Disease") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) association path(MESH:"Alzheimer Disease") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) association bp(GO:"excitatory chemical synaptic transmission") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases bp(GO:learning) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases bp(GO:cognition) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) association bp(GO:"neuronal signal transduction") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) regulates a(CHEBI:metabolite) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) regulates bp(MESH:Glycolysis) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) regulates bp(GO:"response to oxidative stress") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) regulates bp(GO:"cellular respiration") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) negativeCorrelation bp(GO:aging) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) increases act(p(MGI:Vegfc)) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) decreases a(CHEBI:"amyloid-beta") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) negativeCorrelation a(CHEBI:"amyloid-beta") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) decreases a(CHEBI:"amyloid-beta") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) decreases a(CHEBI:"amyloid-beta") |
| pmid:30046111 | a(MESH:"Lymphatic Vessels") decreases a(CHEBI:"amyloid-beta") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) decreases bp(GO:"macrophage migration") |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) decreases a(MESH:Macrophages) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) negativeCorrelation path(MESH:Inflammation) |
| pmid:30046111 | act(a(MESH:"Lymphatic Vessels")) decreases a(HBP:HBP00018) |
| pmid:30046111 | tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) association act(a(MESH:"Lymphatic Vessels")) |
| pmid:30046111 | a(CHEBI:verteporfin) decreases a(MESH:"Lymphatic Vessels") |
| pmid:30046111 | a(CHEBI:verteporfin) decreases act(a(MESH:"Lymphatic Vessels")) |
| pmid:30046111 | a(CHEBI:verteporfin) decreases bp(MESH:"Cerebrovascular Circulation") |
| pmid:30046111 | a(CHEBI:verteporfin) decreases tloc(a(CHEBI:"gadolinium atom"), fromLoc(GO:"extracellular space"), toLoc(MESH:"Cerebrospinal Fluid")) |
| pmid:30046111 | bp(MESH:"Cerebrovascular Circulation") association act(a(MESH:"Lymphatic Vessels")) |
| pmid:30046111 | bp(MESH:"Cerebrovascular Circulation") increases act(a(MESH:"Lymphatic Vessels")) |
| pmid:30046111 | bp(MESH:"Cerebrovascular Circulation") positiveCorrelation act(a(MESH:"Lymphatic Vessels")) |
| pmid:30046111 | bp(MESH:"Cerebrovascular Circulation") increases tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) |
| pmid:30126037 | bp(MESH:"Cerebrovascular Circulation") association p(MGI:Mapt, var("p.Pro301Leu")) |
| pmid:30126037 | bp(MESH:"Cerebrovascular Circulation") association path(MESH:"Alzheimer Disease") |
| pmid:30126037 | bp(MESH:"Cerebrovascular Circulation") association path(MESH:"Cognitive Dysfunction") |
| pmid:30046111 | p(MGI:Aqp4) regulates tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) |
| pmid:30046111 | p(MGI:Aqp4) regulates tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Intracellular Space"), toLoc(GO:"extracellular space")) |
| pmid:30046111 | p(MGI:Aqp4) decreases a(CHEBI:"amyloid-beta") |
| pmid:26195256 | act(p(MGI:Aqp4)) decreases a(CHEBI:"amyloid-beta") |
| pmid:30046111 | p(MGI:Aqp4) increases bp(GO:cognition) |
| pmid:19126755 | bp(GO:cognition) positiveCorrelation p(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19126755 | bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA7) |
| pmid:19126755 | bp(GO:cognition) association act(p(HGNC:CHRNA7)) |
| pmid:19721446 | bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA7) |
| pmid:19126755 | bp(GO:cognition) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24511233 | bp(GO:cognition) association path(MESH:"Alzheimer Disease") |
| pmid:11230871 | bp(GO:cognition) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24511233 | bp(GO:cognition) association path(MESH:Schizophrenia) |
| pmid:19721446 | bp(GO:cognition) association path(MESH:Schizophrenia) |
| pmid:24511233 | bp(GO:cognition) association a(MESH:Hippocampus) |
| pmid:24511233 | bp(GO:cognition) association a(MESH:"Cerebral Cortex") |
| pmid:24511233 | bp(GO:cognition) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:26813123 | bp(GO:cognition) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:21482353 | bp(GO:cognition) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:24511233 | bp(GO:cognition) association p(HGNC:CHRM1) |
| pmid:24511233 | bp(GO:cognition) association p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") |
| pmid:24511233 | bp(GO:cognition) association a(MESH:"Prefrontal Cortex") |
| pmid:26813123 | bp(GO:cognition) association bp(GO:"synaptic transmission, glutamatergic") |
| pmid:26813123 | bp(GO:cognition) association a(CHEBI:acetylcholine) |
| pmid:11230871 | bp(GO:cognition) negativeCorrelation a(CHEBI:acetylcholine) |
| pmid:25514383 | bp(GO:cognition) association a(HP:"cholinergic neuron") |
| pmid:28445721 | bp(GO:cognition) association p(FPLX:CHRN) |
| pmid:28445721 | bp(GO:cognition) association p(FPLX:CHRN) |
| pmid:11230871 | bp(GO:cognition) association p(FPLX:CHRN) |
| pmid:21482353 | bp(GO:cognition) positiveCorrelation a(HBP:"alpha-4 beta-2 nAChR") |
| pmid:21482353 | bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA5, var("?")) |
| pmid:21482353 | bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA3, var("?")) |
| pmid:21482353 | bp(GO:cognition) positiveCorrelation p(HGNC:CHRNB4, var("?")) |
| pmid:11230871 | bp(GO:cognition) association complex(a(CHEBI:nicotine), p(FPLX:CHRN)) |
| pmid:11230871 | bp(GO:cognition) association a(CHEBI:neurotransmitter) |
| pmid:24027553 | bp(GO:cognition) negativeCorrelation p(HBP:"Tau C3") |
| pmid:21882945 | bp(GO:cognition) negativeCorrelation path(MESH:Tauopathies) |
| pmid:21882945 | bp(GO:cognition) positiveCorrelation a(PUBCHEM:134222899) |
| pmid:21882945 | bp(GO:cognition) positiveCorrelation a(CHEBI:"NMDA receptor antagonist") |
| pmid:19293145 | bp(GO:memory) association composite(p(HGNC:MAPK1), p(HGNC:MAPK3)) |
| pmid:24511233 | bp(GO:memory) association path(MESH:"Alzheimer Disease") |
| pmid:24511233 | bp(GO:memory) association a(MESH:Hippocampus) |
| pmid:24511233 | bp(GO:memory) association a(MESH:Hippocampus) |
| pmid:19721446 | bp(GO:memory) association a(MESH:Hippocampus) |
| pmid:24511233 | bp(GO:memory) association a(MESH:"Cerebral Cortex") |
| pmid:24511233 | bp(GO:memory) association a(MESH:"Cerebral Cortex") |
| pmid:24511233 | bp(GO:memory) association bp(GO:"long-term synaptic potentiation") |
| pmid:24511233 | bp(GO:memory) association a(MESH:"Prefrontal Cortex") |
| pmid:17009926 | bp(GO:memory) association p(FPLX:CHRN) |
| pmid:11230871 | bp(GO:memory) association p(FPLX:CHRN) |
| pmid:26813123 | bp(GO:memory) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:21482353 | bp(GO:memory) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:26813123 | bp(GO:memory) positiveCorrelation a(CHEBI:acetylcholine) |
| pmid:26813123 | bp(GO:memory) association a(CHEBI:acetylcholine) |
| pmid:26813123 | bp(GO:memory) positiveCorrelation a(MESH:"Cholinergic Neurons") |
| pmid:26813123 | bp(GO:memory) negativeCorrelation bp(HBP:Neurodegeneration) |
| pmid:26813123 | bp(GO:memory) association bp(MESH:"Synaptic Transmission") |
| pmid:26813123 | bp(GO:memory) association p(HGNC:SYP) |
| pmid:24590577 | bp(GO:memory) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pmid:24590577 | bp(GO:memory) association p(HGNC:CHRM1) |
| pmid:19721446 | bp(GO:memory) association p(HGNC:CHRNA7) |
| pmid:19721446 | bp(GO:memory) association a(MESH:"Entorhinal Cortex") |
| pmid:28775333 | bp(GO:memory) positiveCorrelation a(CHEBI:"(-)-epigallocatechin 3-gallate") |
| pmid:28775333 | bp(GO:memory) negativeCorrelation p(MGI:Dyrk1a) |
| pmid:24355211 | bp(GO:memory) negativeCorrelation p(HGNC:GSK3B) |
| pmid:27041503 | bp(GO:memory) positiveCorrelation bp(MESH:"Long-Term Potentiation") |
| pmid:29540553 | bp(GO:memory) positiveCorrelation p(HGNC:SIRT1) |
| pmid:28771976 | bp(GO:memory) association a(HBP:RGFP966) |
| pmid:21843595 | bp(GO:memory) negativeCorrelation p(MGI:Sumo3) |
| pmid:30046111 | bp(GO:"gene expression") association act(a(MESH:"Lymphatic Vessels")) |
| pmid:30046111 | path(MESH:"Huntington Disease") association act(a(MESH:"Lymphatic Vessels")) |
| pmid:26813123 | path(MESH:"Huntington Disease") negativeCorrelation act(p(HGNC:CHAT)) |
| pmid:25437566 | path(MESH:"Huntington Disease") decreases p(HGNC:HSP90AB1) |
| pmid:25437566 | path(MESH:"Huntington Disease") decreases p(HGNC:HSPA8) |
| pmid:25437566 | path(MESH:"Huntington Disease") decreases p(HGNC:HSPA14) |
| pmid:25437566 | path(MESH:"Huntington Disease") decreases p(HGNC:TCP1) |
| pmid:14556719 | path(MESH:"Huntington Disease") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) |
| pmid:14556719 | path(MESH:"Huntington Disease") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) |
| pmid:25784053 | path(MESH:"Huntington Disease") positiveCorrelation p(FPLX:HSPA) |
| pmid:25784053 | path(MESH:"Huntington Disease") negativeCorrelation p(HGNC:ATF6) |
| pmid:29024336 | path(MESH:"Huntington Disease") increases path(MESH:"Proteostasis Deficiencies") |
| pmid:29311797 | path(MESH:"Huntington Disease") association p(HGNC:STUB1) |
| pmid:30046111 | path(MESH:"Parkinson Disease") association act(a(MESH:"Lymphatic Vessels")) |
| pmid:19126755 | path(MESH:"Parkinson Disease") association p(HBP:"alpha-6 alpha-4 beta-2 beta-3 nAChR", loc(MESH:"Basal Ganglia")) |
| pmid:19126755 | path(MESH:"Parkinson Disease") positiveCorrelation path(MESH:Tremor) |
| pmid:19126755 | path(MESH:"Parkinson Disease") positiveCorrelation path(MESH:Hypokinesia) |
| pmid:19126755 | path(MESH:"Parkinson Disease") positiveCorrelation path(MESH:"Muscle Rigidity") |
| pmid:19126755 | path(MESH:"Parkinson Disease") negativeCorrelation path(MESH:"Tobacco Use Disorder") |
| pmid:17009926 | path(MESH:"Parkinson Disease") negativeCorrelation act(p(FPLX:CHRN)) |
| pmid:17009926 | path(MESH:"Parkinson Disease") negativeCorrelation p(FPLX:CHRN) |
| pmid:11230871 | path(MESH:"Parkinson Disease") association p(FPLX:CHRN) |
| pmid:26813123 | path(MESH:"Parkinson Disease") negativeCorrelation a(MESH:"Cholinergic Neurons") |
| pmid:24590577 | path(MESH:"Parkinson Disease") association p(HGNC:CHRM4) |
| pmid:24590577 | path(MESH:"Parkinson Disease") decreases act(a(MESH:"Dopaminergic Neurons")) |
| pmid:24762290 | path(MESH:"Parkinson Disease") decreases path(MESH:Memory) |
| pmid:24762290 | path(MESH:"Parkinson Disease") association path(MESH:Memory) |
| pmid:24762290 | path(MESH:"Parkinson Disease") association complex(HBP:"alpha-4 beta-2 nAChR") |
| pmid:28901280 | path(MESH:"Parkinson Disease") association p(MESH:"Receptors, Nicotinic") |
| pmid:14556719 | path(MESH:"Parkinson Disease") positiveCorrelation bp(GO:"neuron death") |
| pmid:14556719 | path(MESH:"Parkinson Disease") negativeCorrelation bp(GO:"synaptic transmission, dopaminergic") |
| pmid:14556719 | path(MESH:"Parkinson Disease") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:14556719 | path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:PRKN) |
| pmid:14556719 | path(MESH:"Parkinson Disease") association p(HGNC:UCHL1, var("?")) |
| pmid:14556719 | path(MESH:"Parkinson Disease") association p(HGNC:UCHL1, var("p.Ile93Met")) |
| pmid:14556719 | path(MESH:"Parkinson Disease") association a(MESH:"Lewy Bodies") |
| pmid:14556719 | path(MESH:"Parkinson Disease") association p(HGNC:SNCA, var("p.Ala30Pro")) |
| pmid:14556719 | path(MESH:"Parkinson Disease") association p(HGNC:SNCA, var("p.Ala53Thr")) |
| pmid:28803412 | path(MESH:"Parkinson Disease") association p(HGNC:SNCA) |
| pmid:28803412 | path(MESH:"Parkinson Disease") positiveCorrelation a(HBP:HBP00093) |
| pmid:27075649 | path(MESH:"Parkinson Disease") positiveCorrelation a(HBP:HBP00016) |
| pmid:30116051 | path(MESH:"Parkinson Disease") association p(HGNC:PINK1, var("?")) |
| pmid:30116051 | path(MESH:"Parkinson Disease") association p(HGNC:PRKN, var("?")) |
| pmid:30116051 | path(MESH:"Parkinson Disease") association p(HGNC:LRRK2, var("?")) |
| pmid:29024336 | path(MESH:"Parkinson Disease") increases path(MESH:"Proteostasis Deficiencies") |
| pmid:29311797 | path(MESH:"Parkinson Disease") association p(HGNC:STUB1) |
| pmid:26751493 | path(MESH:"Parkinson Disease") association g(DBSNP:rs2471738) |
| pmid:26751493 | path(MESH:"Parkinson Disease") association g(DBSNP:rs242557) |
| pmid:24113872 | path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:LRRK2) |
| pmid:30046111 | bp(GO:"excitatory chemical synaptic transmission") association act(a(MESH:"Lymphatic Vessels")) |
| pmid:19293145 | bp(GO:learning) association path(MESH:"Alzheimer Disease") |
| pmid:24511233 | bp(GO:learning) association path(MESH:"Alzheimer Disease") |
| pmid:24511233 | bp(GO:learning) association a(MESH:Hippocampus) |
| pmid:24511233 | bp(GO:learning) association a(MESH:Hippocampus) |
| pmid:24511233 | bp(GO:learning) association a(MESH:"Cerebral Cortex") |
| pmid:24511233 | bp(GO:learning) association a(MESH:"Cerebral Cortex") |
| pmid:24511233 | bp(GO:learning) association bp(GO:"long-term synaptic potentiation") |
| pmid:24511233 | bp(GO:learning) association a(MESH:"Prefrontal Cortex") |
| pmid:17009926 | bp(GO:learning) association p(FPLX:CHRN) |
| pmid:26813123 | bp(GO:learning) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:26813123 | bp(GO:learning) positiveCorrelation bp(GO:"synaptic transmission, cholinergic") |
| pmid:21482353 | bp(GO:learning) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:26813123 | bp(GO:learning) association a(CHEBI:acetylcholine) |
| pmid:24590577 | bp(GO:learning) association p(HGNC:CHRM1) |
| pmid:19721446 | bp(GO:learning) association p(HGNC:CHRNA7) |
| pmid:24808823 | bp(GO:learning) negativeCorrelation p(MGI:Ttbk1) |
| pmid:24808823 | bp(GO:learning) negativeCorrelation p(MGI:Cdk5) |
| pmid:24808823 | bp(GO:learning) positiveCorrelation surf(p(MGI:Grin2b)) |
| pmid:24355211 | bp(GO:learning) negativeCorrelation p(HGNC:GSK3B) |
| pmid:29540553 | bp(GO:learning) positiveCorrelation p(HGNC:SIRT1) |
| pmid:21843595 | bp(GO:learning) negativeCorrelation p(MGI:Sumo3) |
| pmid:30046111 | bp(GO:"neuronal signal transduction") association act(a(MESH:"Lymphatic Vessels")) |
| pmid:24590577 | bp(GO:"neuronal signal transduction") association p(HGNC:CHRM1) |
| pmid:11230871 | bp(GO:"response to oxidative stress") negativeCorrelation p(FPLX:CHRN) |
| pmid:14556719 | bp(GO:"response to oxidative stress") increases p(HGNC:SOD1, pmod(Ub), var("?")) |
| pmid:14556719 | bp(GO:"response to oxidative stress") increases p(HGNC:SOD1, pmod(HBP:misfolding), var("?")) |
| pmid:27671637 | bp(GO:"response to oxidative stress") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:23528736 | bp(GO:"response to oxidative stress") increases bp(GO:autophagy) |
| pmid:22419736 | bp(GO:"response to oxidative stress") increases p(HGNC:AK1) |
| pmid:30126037 | bp(GO:"cellular respiration") association act(a(MESH:Mitochondria)) |
| pmid:30046111 | bp(GO:"immune response") association bp(GO:aging) |
| pmid:30046111 | bp(GO:"inflammatory response") association bp(GO:aging) |
| pmid:27522251 | bp(GO:"inflammatory response") causesNoChange path(MESH:"Memory Disorders") |
| pmid:8940412 | bp(GO:"inflammatory response") positiveCorrelation act(p(RGD:Crh)) |
| pmid:8940412 | bp(GO:"inflammatory response") negativeCorrelation a(CHEBI:antalarmin) |
| pmid:30126037 | bp(GO:"inflammatory response") association bp(GO:"cellular senescence") |
| pmid:18494933 | bp(GO:"inflammatory response") increases p(HGNC:DKK1) |
| pmid:16566606 | bp(GO:"inflammatory response") increases a(CHEBI:peroxynitrite) |
| pmid:30046111 | bp(GO:"phospholipid metabolic process") association bp(GO:aging) |
| pmid:30046111 | bp(GO:"extracellular matrix organization") association bp(GO:aging) |
| pmid:30046111 | bp(GO:"cell adhesion") association bp(GO:aging) |
| pmid:21214928 | bp(GO:"cell adhesion") association p(HGNC:APP) |
| pmid:28901280 | bp(GO:"cell adhesion") association a(MESH:Acetylcholine) |
| pmid:30046111 | bp(GO:"endothelial tube morphogenesis") association bp(GO:aging) |
| pmid:27087442 | p(MGI:Cdk5r1) negativeCorrelation p(MGI:Cdk5) |
| pmid:27087442 | p(MGI:Cdk5r1) positiveCorrelation act(a(MESH:Neurons)) |
| pmid:30046111 | p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels") |
| pmid:30046111 | p(MGI:Vegfc) increases act(a(MESH:"Lymphatic Vessels")) |
| pmid:30046111 | p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels") |
| pmid:30046111 | p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels") |
| pmid:30046111 | p(MGI:Vegfc) increases act(a(MESH:"Lymphatic Vessels")) |
| pmid:30046111 | p(MGI:Vegfc) causesNoChange a(MESH:"Lymphatic Vessels") |
| pmid:30046111 | p(MGI:Vegfc) increases path(MESH:"Spatial Learning") |
| pmid:30046111 | p(MGI:Vegfc) increases bp(GO:"stem cell proliferation") |
| pmid:30046111 | p(MGI:Vegfc) increases bp(GO:cognition) |
| pmid:30046111 | p(MGI:Vegfc) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymph Nodes")) |
| pmid:30046111 | p(MGI:Vegfc) causesNoChange tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymph Nodes")) |
| pmid:30046111 | p(MGI:Vegfc) causesNoChange a(CHEBI:"amyloid-beta") |
| pmid:30046111 | p(MGI:Vegfc) causesNoChange path(HP:"Abnormal lymphatic vessel morphology") |
| pmid:30046111 | composite(a(CHEBI:"poly(ethylene glycol dimethacrylate)"), p(MGI:Vegfc)) increases a(MESH:"Lymphatic Vessels") |
| pmid:30046111 | p(MGI:Vegfc, var("p.Cys156Ser")) increases a(MESH:"Lymphatic Vessels") |
| pmid:30046111 | p(MGI:Vegfc, var("p.Cys156Ser")) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:Brain)) |
| pmid:30046111 | path(MESH:Inflammation) negativeCorrelation act(a(MESH:"Lymphatic Vessels")) |
| pmid:22040696 | path(MESH:Inflammation) increases path(MESH:"Renal Insufficiency") |
| pmid:24027553 | path(MESH:Inflammation) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24027553 | path(MESH:Inflammation) association act(p(HGNCGENEFAMILY:Caspases)) |
| pmid:26195256 | path(MESH:Inflammation) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:30232325 | p(HGNC:APP) increases act(p(HGNC:WNT3A)) |
| pmid:30232325 | p(HGNC:APP) increases act(p(HGNC:WNT5A)) |
| pmid:30232325 | p(HGNC:APP) increases bp(GO:"canonical Wnt signaling pathway") |
| pmid:30232325 | p(HGNC:APP) increases bp(GO:"non-canonical Wnt signaling pathway") |
| pmid:11230871 | act(p(HGNC:APP)) association p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) |
| pmid:30232325 | p(HGNC:APP) increases act(p(HGNC:DKK1)) |
| pmid:30232325 | p(HGNC:APP) increases act(p(HGNC:DKK1)) |
| pmid:30232325 | p(HGNC:APP) increases bp(HBP:HBP00061) |
| pmid:10656250 | p(HGNC:APP, loc(GO:"endoplasmic reticulum")) association p(HGNC:BACE1, loc(GO:"endoplasmic reticulum")) |
| pmid:18650430 | p(HGNC:APP) increases bp(GO:"regulation of cell growth") |
| pmid:18650430 | p(HGNC:APP) increases bp(GO:"synapse assembly") |
| pmid:21214928 | p(HGNC:APP) association bp(GO:"synapse assembly") |
| pmid:18650430 | p(HGNC:APP) increases bp(MESH:"Neuronal Outgrowth") |
| pmid:21214928 | p(HGNC:APP) association bp(MESH:"Neuronal Outgrowth") |
| pmid:18650430 | p(HGNC:APP) increases bp(GO:"cell adhesion") |
| pmid:21214928 | p(HGNC:APP) association bp(GO:"cell adhesion") |
| pmid:22122372 | p(HGNC:APP) increases bp(GO:"cell adhesion") |
| pmid:18650430 | p(HGNC:APP) regulates act(p(HGNC:SLC5A7)) |
| pmid:21214928 | p(HGNC:APP) increases a(CHEBI:"amyloid-beta") |
| pmid:22122372 | p(HGNC:APP) increases a(CHEBI:"amyloid-beta") |
| pmid:21214928 | p(HGNC:APP) association bp(GO:"signal transduction") |
| pmid:21214928 | p(HGNC:APP) association bp(GO:"calcium ion homeostasis") |
| pmid:21214928 | p(HGNC:APP) association bp(GO:"protein transport") |
| pmid:21214928 | p(HGNC:APP) regulates bp(GO:"protein transport") |
| pmid:21214928 | p(HGNC:APP) association p(HGNC:ITGB1) |
| pmid:21214928 | p(HGNC:APP) association bp(GO:"anterograde axonal protein transport") |
| pmid:22122372 | p(HGNC:APP) increases a(MESH:"Amyloid beta-Peptides") |
| pmid:14556719 | p(HGNC:APP) increases a(MESH:"Amyloid beta-Peptides") |
| pmid:22122372 | p(HGNC:APP) association a(HBP:HBP00078) |
| pmid:22122372 | p(HGNC:APP) association a(HBP:HBP00079) |
| pmid:22122372 | p(HGNC:APP) association a(MESH:"Receptors, Cell Surface") |
| pmid:22419736 | p(HGNC:APP) positiveCorrelation p(HGNC:AK1) |
| pmid:26195256 | p(HGNC:APP, loc(GO:"extracellular region")) negativeCorrelation p(CHEBI:"amyloid-beta polypeptide 42", loc(MESH:"Cerebrospinal Fluid")) |
| pmid:27094130 | p(HGNC:APP) association p(HGNC:DAPK1, frag("637_1423")) |
| pmid:27094130 | p(HGNC:APP) association p(HGNC:DAPK1, frag("848_1423")) |
| pmid:27094130 | p(HGNC:APP) association p(HGNC:DAPK1, frag("1271_1423")) |
| pmid:30232325 | act(p(HGNC:WNT3A)) increases bp(GO:"canonical Wnt signaling pathway") |
| pmid:30232325 | act(p(HGNC:WNT3A)) increases bp(GO:"canonical Wnt signaling pathway") |
| pmid:30232325 | act(p(HGNC:WNT3A)) decreases a(CHEBI:"amyloid-beta") |
| pmid:30232325 | act(p(HGNC:WNT3A)) increases a(CHEBI:"amyloid-beta") |
| pmid:30232325 | bp(GO:"canonical Wnt signaling pathway") association p(HGNC:LRP6) |
| pmid:30232325 | bp(GO:"canonical Wnt signaling pathway") decreases a(CHEBI:"amyloid-beta") |
| pmid:30232325 | bp(GO:"canonical Wnt signaling pathway") negativeCorrelation bp(GO:"amyloid-beta formation") |
| pmid:30232325 | act(p(HGNC:WNT5A)) increases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") |
| pmid:30232325 | bp(GO:"Wnt signaling pathway, planar cell polarity pathway") association p(HGNC:VANGL2) |
| pmid:30232325 | bp(GO:"Wnt signaling pathway, planar cell polarity pathway") increases a(CHEBI:"amyloid-beta") |
| pmid:30232325 | bp(GO:"Wnt signaling pathway, planar cell polarity pathway") positiveCorrelation bp(GO:"amyloid-beta formation") |
| pmid:30232325 | p(HGNC:VANGL2) association bp(GO:"Wnt signaling pathway, planar cell polarity pathway") |
| pmid:30232325 | p(HGNC:LRP6) association bp(GO:"canonical Wnt signaling pathway") |
| pmid:30232325 | composite(p(HGNC:APP), p(HGNC:LRP6)) increases bp(GO:"canonical Wnt signaling pathway") |
| pmid:30232325 | composite(p(HGNC:APP), p(HGNC:LRP6)) decreases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") |
| pmid:30232325 | composite(p(HGNC:APP), p(HGNC:LRP6)) decreases a(CHEBI:"amyloid-beta") |
| pmid:30232325 | composite(p(HGNC:APP), p(HGNC:VANGL2)) decreases bp(GO:"canonical Wnt signaling pathway") |
| pmid:30232325 | composite(p(HGNC:APP), p(HGNC:VANGL2)) increases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") |
| pmid:30232325 | composite(p(HGNC:APP), p(HGNC:VANGL2)) increases a(CHEBI:"amyloid-beta") |
| pmid:30232325 | p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) decreases bp(GO:"canonical Wnt signaling pathway") |
| pmid:30232325 | p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) increases bp(GO:"non-canonical Wnt signaling pathway") |
| pmid:30232325 | p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) increases a(CHEBI:"amyloid-beta") |
| pmid:11230871 | p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) association act(p(HGNC:APP)) |
| pmid:11230871 | p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) increases path(MESH:"Plaque, Amyloid") |
| pmid:11230871 | p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) negativeCorrelation p(FPLX:CHRN) |
| pmid:30232325 | bp(GO:"amyloid-beta formation") negativeCorrelation bp(GO:"canonical Wnt signaling pathway") |
| pmid:30232325 | bp(GO:"amyloid-beta formation") positiveCorrelation bp(GO:"Wnt signaling pathway, planar cell polarity pathway") |
| pmid:30232325 | act(p(HGNC:DKK1)) decreases act(p(HGNC:WNT3A)) |
| pmid:30232325 | act(p(HGNC:DKK1)) decreases bp(GO:"canonical Wnt signaling pathway") |
| pmid:30232325 | act(p(HGNC:DKK1)) increases act(p(HGNC:WNT5A)) |
| pmid:30232325 | act(p(HGNC:DKK1)) increases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") |
| pmid:30232325 | p(HGNC:DKK1) increases bp(HBP:HBP00061) |
| pmid:30232325 | p(HGNC:DKK1) decreases a(MESH:"Dendritic Spines") |
| pmid:30232325 | p(HGNC:DKK1) decreases a(MESH:"Dendritic Spines") |
| pmid:30232325 | p(HGNC:DKK1) increases a(CHEBI:"amyloid-beta") |
| pmid:30232325 | p(HGNC:DKK1) increases bp(GO:"amyloid-beta formation") |
| pmid:18494933 | p(HGNC:DKK1) increases act(p(HGNC:GSK3B)) |
| pmid:18494933 | p(HGNC:DKK1) increases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:18494933 | p(HGNC:DKK1) decreases bp(GO:"Wnt signaling pathway") |
| pmid:18494933 | p(HGNC:DKK1) positiveCorrelation deg(p(HGNC:CTNNB1)) |
| pmid:30232325 | composite(p(HGNC:APP), p(HGNC:DKK1)) decreases a(MESH:"Dendritic Spines") |
| pmid:24760868 | a(MESH:"Dendritic Spines") association tloc(p(HGNC:MAPT)) |
| pmid:24760868 | a(MESH:"Dendritic Spines") association p(HGNC:MAPT) |
| pmid:24760868 | a(MESH:"Dendritic Spines") association complex(a(MESH:"Dendritic Spines"), p(HGNC:MAPT)) |
| pmid:27796283 | a(MESH:"Dendritic Spines") positiveCorrelation bp(GO:"dendritic spine development") |
| pmid:27796283 | a(MESH:"Dendritic Spines") negativeCorrelation act(p(HGNC:RHOA)) |
| pmid:30232325 | a(CHEBI:"fasudil hydrochloride") decreases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") |
| pmid:30232325 | a(CHEBI:"fasudil hydrochloride") decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:30232325 | a(CHEBI:"fasudil hydrochloride") decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:25514383 | a(CHEBI:"amyloid-beta polypeptide 40") decreases act(a(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:25514383 | a(CHEBI:"amyloid-beta polypeptide 40") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:14556719 | a(CHEBI:"amyloid-beta polypeptide 40") increases a(HBP:"amyloid-beta fibrils") |
| pmid:26195256 | a(CHEBI:"amyloid-beta polypeptide 40") association path(MESH:"Alzheimer Disease") |
| pmid:26195256 | a(CHEBI:"amyloid-beta polypeptide 40") isA a(CHEBI:"amyloid-beta") |
| pmid:30232325 | composite(a(CHEBI:"fasudil hydrochloride"), p(HGNC:DKK1)) causesNoChange a(MESH:"Dendritic Spines") |
| pmid:30232325 | composite(a(CHEBI:"fasudil hydrochloride"), p(HGNC:DKK1)) causesNoChange a(CHEBI:"amyloid-beta") |
| pmid:29255009 | p(MGI:Fkbp1b) increases path(MESH:Memory) |
| pmid:29255009 | p(MGI:Fkbp1b) increases bp(MESH:Aging) |
| pmid:29255009 | p(MGI:Fkbp1b) increases act(p(MGI:Eif3g)) |
| pmid:29255009 | p(MGI:Fkbp1b) increases act(p(MGI:Pla2g7)) |
| pmid:29255009 | p(MGI:Fkbp1b) increases act(p(MGI:S100b)) |
| pmid:29255009 | p(MGI:Fkbp1b) increases act(p(MGI:Snapc2)) |
| pmid:29255009 | p(MGI:Fkbp1b) increases bp(MESH:"Facilitated Diffusion") |
| pmid:29255009 | p(MGI:Fkbp1b) increases bp(GO:"ectoderm development") |
| pmid:29255009 | p(MGI:Fkbp1b) increases bp(GO:"regulation of actin cytoskeleton organization") |
| pmid:29255009 | p(MGI:Fkbp1b) increases act(p(MESH:"Mitogen-Activated Protein Kinases")) |
| pmid:29255009 | p(MGI:Fkbp1b) decreases act(p(MESH:"Membrane Transport Proteins")) |
| pmid:29255009 | p(MGI:Fkbp1b) decreases bp(GO:"blood vessel development") |
| pmid:29255009 | p(MGI:Fkbp1b) decreases bp(GO:"regulation of cellular component movement") |
| pmid:29255009 | p(MGI:Fkbp1b) decreases a(GO:"cytoplasmic vesicle") |
| pmid:29255009 | p(MGI:Fkbp1b) decreases tloc(a(CHEBI:"calcium(2+)")) |
| pmid:29255009 | p(MGI:Fkbp1b) regulates p(MGI:Capn1) |
| pmid:29255009 | p(MGI:Fkbp1b) regulates p(MGI:Ppp3cc) |
| pmid:29255009 | p(MGI:Fkbp1b) decreases p(MGI:Hif1an) |
| pmid:29255009 | p(MGI:Fkbp1b) decreases p(MGI:Nfkb1) |
| pmid:24762290 | path(MESH:Memory) association path(MESH:"Parkinson Disease") |
| pmid:24762290 | path(MESH:Memory) association complex(HBP:"alpha-4 beta-2 nAChR") |
| pmid:28901280 | path(MESH:Memory) association p(MESH:"Receptors, Nicotinic") |
| pmid:29255009 | p(HBP:"AAV-FKBP1B") increases p(MGI:Fkbp1b, loc(MESH:Hippocampus)) |
| pmid:29255009 | bp(MESH:Aging) decreases p(MGI:Map2) |
| pmid:29255009 | bp(MESH:Aging) regulates p(MGI:Capn1) |
| pmid:29255009 | bp(MESH:Aging) regulates p(MGI:Ppp3cc) |
| pmid:24511233 | bp(MESH:Aging) association path(MESH:"Alzheimer Disease") |
| pmid:23528736 | bp(MESH:Aging) increases path(MESH:"Alzheimer Disease") |
| pmid:25437566 | bp(MESH:Aging) increases p(HGNC:TPR) |
| pmid:25437566 | bp(MESH:Aging) increases p(HGNC:TPR) |
| pmid:25437566 | bp(MESH:Aging) increases p(HGNC:TPR) |
| pmid:25437566 | bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") |
| pmid:25437566 | bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") |
| pmid:25437566 | bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") |
| pmid:25437566 | bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") |
| pmid:25784053 | bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") |
| pmid:25437566 | bp(MESH:Aging) decreases p(FPLX:HSPA) |
| pmid:25437566 | bp(MESH:Aging) decreases p(FPLX:HSPA) |
| pmid:25784053 | bp(MESH:Aging) decreases p(FPLX:HSPA) |
| pmid:25437566 | bp(MESH:Aging) increases p(FPLX:HSPB) |
| pmid:25437566 | bp(MESH:Aging) increases p(FPLX:HSPB) |
| pmid:25784053 | bp(MESH:Aging) increases p(FPLX:HSPB) |
| pmid:25437566 | bp(MESH:Aging) decreases p(HGNC:HSPD1) |
| pmid:25437566 | bp(MESH:Aging) increases p(HGNC:HSPA2) |
| pmid:25437566 | bp(MESH:Aging) increases p(HGNC:DNAJB2) |
| pmid:25437566 | bp(MESH:Aging) decreases p(HGNC:HSPA12A) |
| pmid:25437566 | bp(MESH:Aging) decreases p(HGNC:TOMM70) |
| pmid:25437566 | bp(MESH:Aging) decreases p(HGNC:HSP90AB1) |
| pmid:25437566 | bp(MESH:Aging) decreases p(HGNC:HSPA8) |
| pmid:25437566 | bp(MESH:Aging) decreases p(HGNC:HSPA14) |
| pmid:25437566 | bp(MESH:Aging) decreases p(HGNC:TCP1) |
| pmid:25784053 | bp(MESH:Aging) regulates bp(HBP:Proteostasis) |
| pmid:25784053 | bp(MESH:Aging) decreases p(FPLX:HSP90) |
| pmid:29311797 | bp(MESH:Aging) increases p(FPLX:HSP90) |
| pmid:29311797 | bp(MESH:Aging) decreases p(FPLX:HSP90) |
| pmid:29311797 | bp(MESH:Aging) decreases p(FPLX:HSP90) |
| pmid:23528736 | bp(MESH:Aging) decreases bp(GO:autophagy) |
| pmid:23528736 | bp(MESH:Aging) decreases act(p(FPLX:Proteasome)) |
| pmid:29311797 | bp(MESH:Aging) decreases act(p(FPLX:Proteasome)) |
| pmid:29311797 | bp(MESH:Aging) decreases act(p(FPLX:Proteasome)) |
| pmid:28420982 | bp(MESH:Aging) association tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"cell body")) |
| pmid:28420982 | bp(MESH:Aging) association tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:dendrite)) |
| pmid:29311797 | bp(MESH:Aging) association path(MESH:"Neurodegenerative Diseases") |
| pmid:29311797 | bp(MESH:Aging) decreases bp(GO:"protein folding") |
| pmid:29311797 | bp(MESH:Aging) increases path(MESH:"Protein Aggregation, Pathological") |
| pmid:29311797 | bp(MESH:Aging) decreases bp(MESH:Proteolysis) |
| pmid:29311797 | bp(MESH:Aging) decreases bp(GO:"chaperone-mediated autophagy") |
| pmid:29311797 | bp(MESH:Aging) decreases bp(GO:"chaperone-mediated autophagy") |
| pmid:29311797 | bp(MESH:Aging) decreases p(HGNC:PPID) |
| pmid:29311797 | bp(MESH:Aging) decreases p(HGNC:PPID) |
| pmid:29311797 | bp(MESH:Aging) increases p(HGNC:FKBP5) |
| pmid:29311797 | bp(MESH:Aging) increases p(HGNC:FKBP5) |
| pmid:29311797 | bp(MESH:Aging) decreases p(HGNC:PPP5C) |
| pmid:29311797 | bp(MESH:Aging) decreases p(HGNC:PPP5C) |
| pmid:29311797 | bp(MESH:Aging) decreases p(HGNC:AHSA1) |
| pmid:29311797 | bp(MESH:Aging) decreases p(HGNC:AHSA1) |
| pmid:29311797 | bp(MESH:Aging) decreases p(HGNC:FKBP4) |
| pmid:29311797 | bp(MESH:Aging) decreases p(HGNC:STIP1) |
| pmid:29311797 | bp(MESH:Aging) decreases p(HGNC:PTGES3) |
| pmid:29311797 | bp(MESH:Aging) increases p(FPLX:HSP90, pmod(Ph)) |
| pmid:29311797 | bp(MESH:Aging) increases p(FPLX:HSP90, pmod(Ac)) |
| pmid:29311797 | bp(MESH:Aging) increases p(FPLX:HSP90, pmod(NO)) |
| pmid:29311797 | bp(MESH:Aging) increases p(FPLX:HSP90, pmod(Ub)) |
| pmid:29255009 | p(MGI:Eif3g) increases bp(MESH:Aging) |
| pmid:29255009 | p(MGI:Pla2g7) increases bp(MESH:Aging) |
| pmid:29255009 | p(MGI:S100b) increases bp(MESH:Aging) |
| pmid:29255009 | p(MGI:Snapc2) increases bp(MESH:Aging) |
| pmid:29255009 | path(MESH:Aging) decreases bp(MESH:"Facilitated Diffusion") |
| pmid:29255009 | path(MESH:Aging) decreases bp(GO:"ectoderm development") |
| pmid:29255009 | path(MESH:Aging) decreases bp(GO:"regulation of actin cytoskeleton organization") |
| pmid:29255009 | path(MESH:Aging) decreases act(p(MESH:"Mitogen-Activated Protein Kinases")) |
| pmid:29255009 | path(MESH:Aging) increases act(p(MESH:"Membrane Transport Proteins")) |
| pmid:29255009 | path(MESH:Aging) increases bp(GO:"blood vessel development") |
| pmid:29255009 | path(MESH:Aging) increases bp(GO:"regulation of cellular component movement") |
| pmid:29255009 | path(MESH:Aging) increases a(GO:"cytoplasmic vesicle") |
| pmid:29255009 | path(MESH:Aging) increases p(MGI:Hif1an) |
| pmid:29255009 | path(MESH:Aging) increases p(MGI:Nfkb1) |
| pmid:19126755 | path(MESH:Aging) negativeCorrelation p(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19126755 | path(MESH:Aging) negativeCorrelation p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | path(MESH:Aging) decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | path(MESH:Aging) decreases p(MGI:Chrna4) |
| pmid:19126755 | path(MESH:Aging) negativeCorrelation p(MGI:Chrna4) |
| pmid:19126755 | path(MESH:Aging) negativeCorrelation p(MGI:Chrna7) |
| pmid:26195256 | path(MESH:Aging) association path(MESH:"Alzheimer Disease") |
| pmid:26195256 | path(MESH:Aging) decreases a(MESH:"Cerebrospinal Fluid") |
| pmid:19126755 | a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases act(p(FPLX:CREB), ma(tscript)) |
| pmid:19126755 | a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases a(CHEBI:anandamide) |
| pmid:19126755 | a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(GO:"signal release") |
| pmid:19126755 | a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(MESH:"Neuronal Plasticity") |
| pmid:19126755 | a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(GO:"neuron migration") |
| pmid:22040696 | tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Cytoplasm)) increases bp(GO:"neuron migration") |
| pmid:19126755 | a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(GO:"neuron differentiation") |
| pmid:19293145 | a(CHEBI:"calcium(2+)") association act(p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors")) |
| pmid:23038257 | a(CHEBI:"calcium(2+)") increases act(p(MESH:"Receptors, Nicotinic")) |
| pmid:17009926 | tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(GO:cytosol)) |
| pmid:26472524 | tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases bp(GO:"membrane depolarization") |
| pmid:26472524 | a(CHEBI:"calcium(2+)") regulates act(p(FPLX:CHRN)) |
| pmid:26813123 | a(CHEBI:"calcium(2+)") regulates p(FPLX:CHRN) |
| pmid:26813123 | a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:26813123 | a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:26813123 | a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:dopamine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:26813123 | a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:serotonin), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:26813123 | a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:noradrenaline), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:26813123 | a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:26088141 | a(CHEBI:"calcium(2+)") association act(a(MESH:"Calcium Channels")) |
| pmid:19721446 | a(CHEBI:"calcium(2+)") increases act(p(HGNC:CHRNA7)) |
| pmid:19721446 | a(CHEBI:"calcium(2+)") increases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:24027553 | a(CHEBI:"calcium(2+)") increases act(p(HGNCGENEFAMILY:Calpains)) |
| pmid:24027553 | a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases act(p(HGNCGENEFAMILY:Calpains)) |
| pmid:24027553 | a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases act(p(HGNCGENEFAMILY:Calpains)) |
| pmid:2123288 | a(CHEBI:"calcium(2+)") increases act(p(FPLX:CALM)) |
| pmid:2833519 | a(CHEBI:"calcium(2+)") increases act(p(HGNC:S100B)) |
| pmid:10537045 | a(CHEBI:"calcium(2+)") positiveCorrelation complex(p(HGNC:MAPT), p(HGNC:TGM2)) |
| pmid:23702978 | a(CHEBI:"calcium(2+)") association p(HGNC:MAP3K7) |
| pmid:23702978 | tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases act(p(HGNC:NLRP3)) |
| pmid:29255009 | a(CHEBI:sirolimus) decreases bp(HBP:"PI3K-Akt signaling pathway") |
| pmid:25784053 | a(CHEBI:sirolimus) decreases act(p(FPLX:mTORC1)) |
| pmid:25784053 | a(CHEBI:sirolimus) decreases path(MESH:"Protein Aggregation, Pathological") |
| pmid:25784053 | a(CHEBI:sirolimus) decreases path(MESH:"Huntington Disease") |
| pmid:25784053 | a(CHEBI:sirolimus) decreases path(MESH:"Machado-Joseph Disease") |
| pmid:25784053 | a(CHEBI:sirolimus) decreases path(MESH:"Alzheimer Disease") |
| pmid:25784053 | a(CHEBI:sirolimus) decreases path(MESH:"Parkinson Disease") |
| pmid:25784053 | a(CHEBI:sirolimus) decreases path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:27594586 | a(CHEBI:sirolimus) decreases bp(GO:"TOR signaling") |
| pmid:27594586 | a(CHEBI:sirolimus) increases r(HGNC:MMP9) |
| pmid:27594586 | a(CHEBI:sirolimus) increases r(HGNC:MMP2) |
| pmid:30116051 | a(CHEBI:sirolimus) increases bp(GO:autophagy) |
| pmid:29626319 | a(CHEBI:sirolimus) increases bp(GO:autophagy) |
| pmid:30116051 | a(CHEBI:sirolimus) decreases p(HGNC:SNCA) |
| pmid:30116051 | a(CHEBI:sirolimus) decreases p(HGNC:FUS) |
| pmid:30116051 | a(CHEBI:sirolimus) decreases p(HGNC:HTT) |
| pmid:24027553 | a(CHEBI:sirolimus) increases bp(MESH:Autophagy) |
| pmid:23528736 | a(CHEBI:sirolimus) increases deg(p(HGNC:MAPT)) |
| pmid:26751493 | a(CHEBI:sirolimus) increases bp(GO:macroautophagy) |
| pmid:29626319 | a(CHEBI:sirolimus) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(CHEBI:sirolimus) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29255009 | bp(HBP:"PI3K-Akt signaling pathway") causesNoChange act(p(MGI:Fkbp1b)) |
| pmid:29255009 | act(complex(a(CHEBI:sirolimus), p(MGI:Fkbp1b))) decreases bp(HBP:"PI3K-Akt signaling pathway") |
| pmid:29255009 | act(complex(a(CHEBI:sirolimus), p(MGI:Fkbp1a))) decreases bp(HBP:"PI3K-Akt signaling pathway") |
| pmid:29255009 | p(MGI:Fkbp1a) decreases bp(HBP:"PI3K-Akt signaling pathway") |
| pmid:30126037 | act(p(MGI:Nfkb1)) increases bp(MESH:"Cell Survival") |
| pmid:30126037 | act(p(MGI:Nfkb1)) increases bp(GO:"inflammatory response") |
| pmid:10656250 | p(HGNC:BACE1) increases sec(a(HBP:"sAPP-beta")) |
| pmid:24590577 | p(HGNC:BACE1) increases a(HBP:"sAPP-beta") |
| pmid:10656250 | p(HGNC:BACE1) causesNoChange sec(a(HBP:"sAPP-alpha")) |
| pmid:10656250 | p(HGNC:BACE1) causesNoChange p(HGNC:APP) |
| pmid:10656250 | p(HGNC:BACE1, loc(GO:"endoplasmic reticulum")) association p(HGNC:APP, loc(GO:"endoplasmic reticulum")) |
| pmid:24590577 | p(HGNC:BACE1) increases deg(p(HGNC:APP)) |
| pmid:21718217 | p(HGNC:BACE1) decreases p(HGNC:APP) |
| pmid:10656250 | p(HGNC:BACE1) increases p(HGNC:APP, frag("672_770")) |
| pmid:10656250 | p(HGNC:BACE1) association a(HBP:APP695) |
| pmid:10656250 | p(HGNC:BACE1) association a(HBP:APP751) |
| pmid:18650430 | act(p(HGNC:BACE1), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("11_*")), p(HGNC:APP, frag("1_10")))) |
| pmid:21214928 | p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) |
| pmid:21214928 | p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) |
| pmid:21214928 | p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) |
| pmid:22122372 | p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) |
| pmid:21214928 | p(HGNC:BACE1) increases bp(GO:"neuron death") |
| pmid:21214928 | p(HGNC:BACE1) decreases bp(GO:"synaptic transmission, cholinergic") |
| pmid:21214928 | p(HGNC:BACE1) decreases bp(GO:memory) |
| pmid:21214928 | p(HGNC:BACE1) increases p(HGNC:APP, frag("672_713")) |
| pmid:21214928 | p(HGNC:BACE1) increases p(HGNC:APP, frag("672_711")) |
| pmid:22122372 | p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00042), a(HBP:HBP00081))) |
| pmid:22122372 | p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00042), a(HBP:HBP00081))) |
| pmid:22122372 | p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta") |
| pmid:18986241 | act(p(HGNC:BACE1)) increases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta") |
| pmid:19126755 | p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:24590577 | p(HGNC:BACE1) increases a(HBP:C99) |
| pmid:21718217 | p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:14556719 | p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(MESH:"Amyloid beta-Peptides"))) |
| pmid:26195256 | act(p(HGNC:BACE1)) increases a(HBP:"amyloid-beta derived diffusible ligands") |
| pmid:19293145 | a(HBP:"sAPP-beta") decreases act(a(CHEBI:"amyloid-beta")) |
| pmid:10656250 | p(HGNC:BACE1, var("p.?")) causesNoChange sec(a(HBP:"sAPP-beta")) |
| pmid:24590577 | a(HBP:"sAPP-alpha") increases bp(MESH:Neuroprotection) |
| pmid:10656250 | p(HGNC:CTSD) causesNoChange sec(a(HBP:"sAPP-beta")) |
| pmid:24027553 | act(p(HGNC:CTSD)) increases p(HGNC:MAPT, frag("?", "29kD")) |
| pmid:24027553 | act(p(HGNC:CTSD)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(p(HGNC:CTSD)) increases deg(p(HGNC:MAPT)) |
| pmid:23528736 | p(HGNC:CTSD) increases deg(p(HGNC:MAPT)) |
| pmid:29626319 | p(HGNC:CTSD) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(p(HGNC:CTSD)) increases p(HGNC:MAPT, frag("?", "29kD"), pmod(Ph)) |
| pmid:24027553 | act(p(HGNC:CTSD)) increases path(MESH:Neuroprotection) |
| pmid:24027553 | act(p(HGNC:CTSD)) decreases path(HBP:neurotoxicity) |
| pmid:10656250 | a(HBP:APP695) association p(HGNC:BACE1) |
| pmid:10656250 | a(HBP:APP751) association p(HGNC:BACE1) |
| pmid:22791904 | a(PUBCHEM:11249342) increases path(MESH:Nausea) |
| pmid:22791904 | a(PUBCHEM:11249342) causesNoChange path(MESH:Nausea) |
| pmid:22791904 | a(PUBCHEM:11249342) increases path(MESH:Vomiting) |
| pmid:22791904 | a(PUBCHEM:11249342) causesNoChange path(MESH:Vomiting) |
| pmid:22791904 | a(PUBCHEM:11249342) decreases p(HBP:"sAPP-alpha") |
| pmid:22791904 | a(PUBCHEM:11249342) decreases p(HBP:"sAPP-beta") |
| pmid:22791904 | a(PUBCHEM:11249342) decreases p(HGNC:MAPT) |
| pmid:22791904 | a(PUBCHEM:11249342) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:22791904 | a(PUBCHEM:11249342) decreases p(HGNC:C3) |
| pmid:22791904 | a(PUBCHEM:11249342) decreases p(HGNC:CCL2) |
| pmid:22791904 | a(PUBCHEM:11249342) decreases p(HGNC:CHI3L1) |
| pmid:22791904 | a(PUBCHEM:11249342) causesNoChange p(HGNC:CFH) |
| pmid:19721446 | path(MESH:Nausea) association a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") |
| pmid:19721446 | path(MESH:Vomiting) association a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") |
| pmid:24760868 | act(p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(Ph)) |
| pmid:26837465 | p(HGNC:MAPT) decreases act(p(HGNC:ESR1), ma(tscript)) |
| pmid:19293145 | p(HGNC:MAPT) association a(MESH:"Neurofibrillary Tangles") |
| pmid:14556719 | p(HGNC:MAPT) association a(MESH:"Neurofibrillary Tangles") |
| pmid:14556719 | deg(p(HGNC:MAPT)) increases a(MESH:"Neurofibrillary Tangles") |
| pmid:27574109 | p(HGNC:MAPT) association a(MESH:"Neurofibrillary Tangles") |
| pmid:26813123 | act(p(HGNC:MAPT)) association act(p(HGNC:CHRM1)) |
| pmid:24590577 | p(HGNC:MAPT) regulates bp(GO:"microtubule anchoring") |
| pmid:24590577 | p(HGNC:MAPT) regulates bp(GO:"axonal transport") |
| pmid:21734277 | tloc(p(HGNC:MAPT)) causesNoChange bp(GO:"axonal transport") |
| pmid:28420982 | p(HGNC:MAPT) regulates bp(GO:"axonal transport") |
| pmid:25514383 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:14556719 | p(HGNC:MAPT) association path(MESH:"Alzheimer Disease") |
| pmid:24027553 | p(HGNC:MAPT) association path(MESH:"Alzheimer Disease") |
| pmid:24027553 | p(HGNC:MAPT) association path(MESH:"Alzheimer Disease") |
| pmid:27574109 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27574109 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:30126037 | p(HGNC:MAPT) association path(MESH:"Alzheimer Disease") |
| pmid:28420982 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28420982 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29238289 | p(HGNC:MAPT) biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:14556719 | p(HGNC:MAPT) association a(GO:microtubule) |
| pmid:28420982 | p(HGNC:MAPT) increases a(GO:microtubule) |
| pmid:29626319 | p(HGNC:MAPT) increases a(GO:microtubule) |
| pmid:30116051 | p(HGNC:MAPT) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:23528736 | deg(p(HGNC:MAPT)) association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:29215007 | p(HGNC:MAPT) increases bp(GO:"actin filament bundle assembly") |
| pmid:29215007 | p(HGNC:MAPT) increases bp(GO:"actin filament bundle assembly") |
| pmid:24027553 | p(HGNC:MAPT) increases path(MESH:"Nerve Degeneration") |
| pmid:24027553 | deg(p(HGNC:MAPT)) association bp(GO:autophagy) |
| pmid:26751493 | p(HGNC:MAPT) decreases bp(GO:autophagy) |
| pmid:25378699 | deg(p(HGNC:MAPT)) positiveCorrelation p(HGNC:MAPT, pmod(Ub)) |
| pmid:24905733 | act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(Ub)) |
| pmid:27574109 | p(HGNC:MAPT) association a(HBP:pretangles) |
| pmid:27574109 | p(HGNC:MAPT) association a(HBP:"Braak_Stage I") |
| pmid:27574109 | p(HGNC:MAPT) association a(HBP:"Braak_Stage II") |
| pmid:27574109 | p(HGNC:MAPT) association a(HBP:"Corticobasal Degeneration") |
| pmid:27574109 | p(HGNC:MAPT) positiveCorrelation a(HBP:"Corticobasal Degeneration") |
| pmid:27574109 | p(HGNC:MAPT) positiveCorrelation a(HBP:"Corticobasal Degeneration") |
| pmid:27574109 | p(HGNC:MAPT) association a(GO:"Pick body") |
| pmid:27574109 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pmid:27574109 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pmid:10391244 | act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:29590627 | p(HGNC:MAPT) increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:26195256 | p(HGNC:MAPT, loc(MESH:"Neurofibrillary Tangles")) positiveCorrelation p(HGNC:MAPT, loc(MESH:"Cerebrospinal Fluid")) |
| pmid:26195256 | p(HGNC:MAPT, loc(MESH:"Cerebrospinal Fluid")) positiveCorrelation p(HGNC:MAPT, loc(MESH:"Neurofibrillary Tangles")) |
| pmid:24760868 | p(HGNC:MAPT, loc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pmid:24760868 | tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pmid:24760868 | p(HGNC:MAPT) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pmid:24760868 | tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) association bp(MESH:"Neuronal Plasticity") |
| pmid:24760868 | p(HGNC:MAPT) regulates bp(MESH:"Neuronal Plasticity") |
| pmid:24760868 | p(HGNC:MAPT) increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:17187063 | p(HGNC:MAPT) increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:24760868 | p(HGNC:MAPT) increases complex(complex(GO:"actin filament bundle"), p(HGNC:MAPT)) |
| pmid:24760868 | p(HGNC:MAPT) association complex(GO:"filamentous actin") |
| pmid:17187063 | p(HGNC:MAPT) directlyIncreases complex(GO:"filamentous actin") |
| pmid:24760868 | tloc(p(HGNC:MAPT)) association a(MESH:"Dendritic Spines") |
| pmid:24760868 | p(HGNC:MAPT) association a(MESH:"Dendritic Spines") |
| pmid:21882945 | p(HGNC:MAPT) increases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:21882945 | deg(p(HGNC:MAPT)) negativeCorrelation bp(GO:aging) |
| pmid:21882945 | p(HGNC:MAPT) increases path(HBP:neurotoxicity) |
| pmid:21882945 | deg(p(HGNC:MAPT)) negativeCorrelation p(HGNC:AKT1) |
| pmid:30126037 | p(HGNC:MAPT) association path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:30126037 | p(HGNC:MAPT) association path(MESH:"Brain Injuries, Traumatic") |
| pmid:28408124 | p(HGNC:MAPT) association a(HBP:"Tau antibody, Tau46") |
| pmid:28420982 | p(HGNC:MAPT) regulates bp(GO:"generation of neurons") |
| pmid:28420982 | p(HGNC:MAPT) increases bp(HP:Neurodegeneration) |
| pmid:28420982 | p(HGNC:MAPT) increases bp(GO:"cell death") |
| pmid:28420982 | p(HGNC:MAPT) association bp(GO:behavior) |
| pmid:28420982 | p(HGNC:MAPT) decreases bp(GO:"synaptic signaling") |
| pmid:28420982 | p(HGNC:MAPT) association bp(GO:"intracellular signal transduction") |
| pmid:28420982 | tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"cell body")) association bp(MESH:Aging) |
| pmid:28420982 | tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:dendrite)) association bp(MESH:Aging) |
| pmid:28420982 | sec(p(HGNC:MAPT)) association a(MESH:Exosomes) |
| pmid:29238289 | p(HGNC:MAPT) association act(a(MESH:Exosomes)) |
| pmid:28420982 | sec(p(HGNC:MAPT)) association a(GO:microvesicle) |
| pmid:28420982 | p(HGNC:MAPT) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:28420982 | sec(p(HGNC:MAPT)) association a(HBP:"Tau aggregates") |
| pmid:27373205 | p(HGNC:MAPT) increases a(HBP:"Tau aggregates") |
| pmid:28420982 | p(HGNC:MAPT) increases a(CHEBI:"calcium(2+)") |
| pmid:28420982 | p(HGNC:MAPT) increases bp(GO:"neuron death") |
| pmid:26751493 | p(HGNC:MAPT) decreases act(p(HGNC:HDAC6)) |
| pmid:28760828 | p(HGNC:MAPT) positiveCorrelation p(HGNC:HDAC6) |
| pmid:26751493 | p(HGNC:MAPT) negativeCorrelation act(complex(GO:"proteasome complex")) |
| pmid:26751493 | p(HGNC:MAPT) positiveCorrelation bp(GO:"clathrin-dependent endocytosis") |
| pmid:27373205 | p(HGNC:MAPT) increases a(HBP:"Tau oligomers") |
| pmid:27373205 | p(HGNC:MAPT) causesNoChange bp(GO:"anterograde axonal protein transport") |
| pmid:27373205 | p(HGNC:MAPT) causesNoChange bp(GO:"retrograde axonal protein transport") |
| pmid:22817713 | p(HGNC:MAPT) association bp(GO:"regulation of microtubule cytoskeleton organization") |
| pmid:22817713 | p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Kinesin)) |
| pmid:22817713 | p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Dyneins)) |
| pmid:29626319 | p(HGNC:MAPT) decreases p(HGNC:PSMD7) |
| pmid:29238289 | p(HGNC:MAPT) association act(a(MESH:Microtubules)) |
| pmid:29238289 | p(HGNC:MAPT, loc(GO:"extracellular region")) increases act(a(MESH:Neurons)) |
| pmid:29238289 | p(HGNC:MAPT, loc(GO:"extracellular region")) decreases a(MESH:Neurons) |
| pmid:29238289 | p(HGNC:MAPT) increases act(a(MESH:Neurons)) |
| pmid:29238289 | p(HGNC:MAPT, loc(GO:"extracellular region")) decreases path(MESH:Memory) |
| pmid:29238289 | p(HGNC:MAPT, loc(GO:"extracellular region")) decreases bp(MESH:"Long-Term Potentiation") |
| pmid:29238289 | p(HGNC:MAPT) association a(MESH:"Transport Vesicles") |
| pmid:29238289 | p(HGNC:MAPT) association p(HGNC:RAB7A) |
| pmid:29238289 | p(HGNC:MAPT) association p(HGNC:RAB1A) |
| pmid:29238289 | p(HGNC:MAPT) decreases p(HBP:"Tau aggregates") |
| pmid:1918161 | p(HGNC:MAPT) directlyIncreases complex(GO:microtubule) |
| pmid:6543144 | p(HGNC:MAPT) association complex(GO:microtubule) |
| pmid:10464280 | p(HGNC:MAPT) association complex(GO:microtubule) |
| pmid:1918161 | p(HGNC:MAPT) positiveCorrelation complex(GO:axon) |
| pmid:1918161 | p(HGNC:MAPT) positiveCorrelation complex(GO:"neuron projection") |
| pmid:6543144 | p(HGNC:MAPT) association complex(GO:neurofilament) |
| pmid:2446784 | p(HGNC:MAPT) association complex(GO:"polysomal ribosome") |
| pmid:11812770 | p(HGNC:MAPT) positiveCorrelation complex(p(HGNC:GSK3B), p(HGNC:MAPT)) |
| pmid:18680553 | p(HGNC:MAPT) association p(HGNC:FYN) |
| pmid:18680553 | p(HGNC:MAPT) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) |
| pmid:18680553 | p(HGNC:MAPT) association bp(GO:myelination) |
| pmid:18467332 | p(HGNC:MAPT) association p(HGNC:SRC, frag("84_145")) |
| pmid:18467332 | p(HGNC:MAPT) isA complex(p(HGNC:MAPT), p(HGNC:SRC)) |
| pmid:18467332 | p(HGNC:MAPT) association p(HGNC:PLCG1, frag("790_851")) |
| pmid:18467332 | p(HGNC:MAPT) isA complex(p(HGNC:MAPT), p(HGNC:PLCG1)) |
| pmid:18467332 | p(HGNC:MAPT) association p(HGNC:GRB2, frag("1_57")) |
| pmid:18467332 | p(HGNC:MAPT) association complex(p(HGNC:GRB2), p(HGNC:MAPT)) |
| pmid:18467332 | p(HGNC:MAPT) association p(HGNC:PIK3R1, frag("3_79")) |
| pmid:18467332 | p(HGNC:MAPT) isA complex(p(HGNC:MAPT), p(HGNC:PIK3R1)) |
| pmid:10464280 | p(HGNC:MAPT) increases complex(complex(GO:microtubule), p(HGNC:MAPT)) |
| pmid:17954934 | p(HGNC:MAPT) isA complex(p(HGNC:BAG1), p(HGNC:MAPT), p(HGNC:STUB1)) |
| pmid:17954934 | p(HGNC:MAPT) positiveCorrelation p(HGNC:BAG1) |
| pmid:8391280 | p(HGNC:MAPT) isA complex(p(HGNC:DCTN1), p(HGNC:MAPT)) |
| pmid:8391280 | p(HGNC:MAPT) increases act(p(INTERPRO:"Dynein associated protein")) |
| pmid:20071522 | p(HGNC:MAPT) isA complex(p(HGNC:FKBP5), p(HGNC:MAPT)) |
| pmid:21367866 | deg(p(HGNC:MAPT)) negativeCorrelation act(p(SFAM:"HSP90 Family")) |
| pmid:2123288 | p(HGNC:MAPT) isA complex(p(FPLX:CALM), p(HGNC:MAPT)) |
| pmid:2123288 | act(p(HGNC:MAPT)) negativeCorrelation complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) |
| pmid:2123288 | act(p(HGNC:MAPT)) increases bp(GO:"microtubule polymerization") |
| pmid:19459590 | act(p(HGNC:MAPT)) positiveCorrelation bp(GO:"microtubule polymerization") |
| pmid:2833519 | p(HGNC:MAPT) association p(HGNC:S100B) |
| pmid:2833519 | p(HGNC:MAPT) isA complex(p(HGNC:MAPT), p(HGNC:S100B)) |
| pmid:12551948 | p(HGNC:MAPT) association p(HGNC:YWHAZ) |
| pmid:12551948 | p(HGNC:MAPT) isA complex(p(HGNC:GSK3B), p(HGNC:MAPT), p(HGNC:YWHAZ)) |
| pmid:21339331 | p(HGNC:MAPT) association p(HGNC:ANXA2) |
| pmid:21339331 | p(HGNC:MAPT) isA complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) |
| pmid:21131359 | p(HGNC:MAPT) association a(CHEBI:"double-stranded DNA") |
| pmid:21131359 | p(HGNC:MAPT) isA complex(a(CHEBI:"double-stranded DNA"), p(HGNC:MAPT)) |
| pmid:21131359 | p(HGNC:MAPT) negativeCorrelation bp(MESH:"Hot Temperature") |
| pmid:16566606 | act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) |
| pmid:16566606 | act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) |
| pmid:16566606 | act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) |
| pmid:16566606 | act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) |
| pmid:24869773 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me2, Lys, 311)) |
| pmid:24869773 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 259)) |
| pmid:24869773 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 290)) |
| pmid:22033876 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 290)) |
| pmid:24869773 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 353)) |
| pmid:24869773 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 24)) |
| pmid:24869773 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 44)) |
| pmid:24869773 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 67)) |
| pmid:24869773 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 190)) |
| pmid:22033876 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 163)) |
| pmid:22033876 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 174)) |
| pmid:22033876 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 180)) |
| pmid:22033876 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 254)) |
| pmid:22033876 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Ub, Lys, 254)) |
| pmid:22033876 | p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 267)) |
| pmid:19251756 | p(HGNC:MAPT) association p(INTERPRO:"Triosephosphate isomerase", pmod(NO)) |
| pmid:19251756 | p(HGNC:MAPT) partOf complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) |
| pmid:10537045 | p(HGNC:MAPT) positiveCorrelation p(HGNC:TGM2) |
| pmid:10537045 | p(HGNC:MAPT) partOf complex(p(HGNC:MAPT), p(HGNC:TGM2)) |
| pmid:24853415 | p(HGNC:MAPT) positiveCorrelation p(HGNC:DAPK1) |
| pmid:24853415 | p(HGNC:MAPT) positiveCorrelation p(HGNC:PIN1, pmod(Ph, Ser, 71)) |
| pmid:22926167 | p(HGNC:MAPT) negativeCorrelation p(HGNC:PIN1, pmod(Ph, Ser, 71)) |
| pmid:19459590 | act(p(HGNC:MAPT)) negativeCorrelation p(HBP:"Tau epitope, AT8") |
| pmid:25031639 | deg(p(HGNC:MAPT)) positiveCorrelation a(HBP:"Tau epitope, PHF1") |
| pmid:29540553 | p(HGNC:MAPT) negativeCorrelation p(MGI:Sirt3) |
| pmid:22926167 | p(HGNC:MAPT) negativeCorrelation p(HGNC:PIN1, pmod(Ph, Ser, 16)) |
| pmid:22926167 | p(HGNC:MAPT) negativeCorrelation p(HGNC:PIN1, pmod(Ph, Ser, 65)) |
| pmid:22926167 | p(HGNC:MAPT) negativeCorrelation p(HGNC:PIN1, pmod(Ac, Lys, 46)) |
| pmid:21214928 | p(HGNC:MAPT, pmod(Ph)) increases a(GO:"neurofibrillary tangle") |
| pmid:28420982 | p(HGNC:MAPT, pmod(Ph)) increases a(GO:"neurofibrillary tangle") |
| pmid:22122372 | p(HGNC:MAPT, pmod(Ph)) association bp(GO:"neurofibrillary tangle assembly") |
| pmid:19293145 | p(HGNC:MAPT, pmod(Ph)) association p(HGNC:FYN) |
| pmid:8282104 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29311797 | p(HGNC:MAPT, pmod(Ph)) association path(MESH:"Alzheimer Disease") |
| pmid:26458742 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27373205 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24027553 | p(HGNC:MAPT, pmod(Ph)) association path(MESH:"Neurofibrillary Tangles") |
| pmid:24027553 | p(HGNC:MAPT, pmod(Ph)) decreases act(a(CHEBI:Thrombin)) |
| pmid:17403556 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(HBP:Neurodegeneration) |
| pmid:24760868 | p(HGNC:MAPT, pmod(Ph)) association act(p(HGNC:MAPT)) |
| pmid:21734277 | p(HGNC:MAPT, pmod(Ph)) association p(HBP:"AT8 tau", pmod(Ph)) |
| pmid:21882945 | p(HGNC:MAPT, pmod(Ph)) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:21882945 | p(HGNC:MAPT, pmod(Ph)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:21882945 | deg(p(HGNC:MAPT, pmod(Ph))) association p(HGNC:BAG2) |
| pmid:22419736 | p(HGNC:MAPT, pmod(Ph)) negativeCorrelation act(p(ECCODE:"2.7.11.31")) |
| pmid:22419736 | p(HGNC:MAPT, pmod(Ph)) association path(MESH:"Retinal Degeneration") |
| pmid:28420982 | p(HGNC:MAPT, pmod(Ph)) increases a(HBP:"Tau oligomers") |
| pmid:28420982 | p(HGNC:MAPT, pmod(Ph)) increases a(HBP:"Tau oligomers") |
| pmid:26195256 | p(HGNC:MAPT, pmod(Ph)) decreases act(p(MESH:Calpain)) |
| pmid:27373205 | p(HGNC:MAPT, pmod(Ph)) increases composite(a(HBP:"Tau antibody, TNT1"), a(HBP:TOC1), p(HGNC:MAPT, pmod(Ph), var("p.S422E")), loc(MESH:Brain)) |
| pmid:22817713 | p(HGNC:MAPT, pmod(Ph)) increases a(HBP:"Tau aggregates") |
| pmid:27260836 | p(HGNC:MAPT, pmod(Ph)) partOf complex(GO:"neurofibrillary tangle") |
| pmid:27260836 | p(HGNC:MAPT, pmod(Ph)) partOf complex(GO:"neurofibrillary tangle") |
| pmid:27260836 | p(HGNC:MAPT, pmod(Ph)) association p(HGNC:PICALM) |
| pmid:27260836 | p(HGNC:MAPT, pmod(Ph)) association p(HGNC:PICALM) |
| pmid:27260836 | p(HGNC:MAPT, pmod(Ph)) partOf complex(GO:"Pick body") |
| pmid:27260836 | p(HGNC:MAPT, pmod(Ph)) partOf complex(GO:"Cajal body") |
| pmid:18467332 | p(HGNC:MAPT, pmod(Ph)) decreases complex(p(HGNC:MAPT), p(HGNC:SRC)) |
| pmid:18467332 | p(HGNC:MAPT, pmod(Ph)) decreases complex(p(HGNC:MAPT), p(HGNC:PLCG1)) |
| pmid:18467332 | p(HGNC:MAPT, pmod(Ph)) decreases complex(p(HGNC:GRB2), p(HGNC:MAPT)) |
| pmid:18467332 | p(HGNC:MAPT, pmod(Ph)) decreases complex(p(HGNC:MAPT), p(HGNC:PIK3R1)) |
| pmid:10464280 | p(HGNC:MAPT, pmod(Ph)) negativeCorrelation rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) |
| pmid:19363271 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(SFAM:"HSP90 Family") |
| pmid:14963027 | p(HGNC:MAPT, pmod(Ph)) association p(HGNC:HSPB1) |
| pmid:14963027 | p(HGNC:MAPT, pmod(Ph)) increases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) |
| pmid:14963027 | act(p(HGNC:MAPT, pmod(Ph))) increases bp(GO:"neuron apoptotic process") |
| pmid:14612456 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, pmod(Ub)) |
| pmid:14612456 | p(HGNC:MAPT, pmod(Ph)) isA complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) |
| pmid:17954934 | p(HGNC:MAPT, pmod(Ph)) negativeCorrelation p(HGNC:BAG1) |
| pmid:23943618 | p(HGNC:MAPT, pmod(Ph)) negativeCorrelation complex(p(FPLX:PPP2), p(HGNC:MAPT)) |
| pmid:16630055 | p(HGNC:MAPT, pmod(Ph)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) |
| pmid:25378699 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, pmod(Sumo, Lys, 340)) |
| pmid:29062069 | p(HGNC:MAPT, pmod(Ph)) negativeCorrelation act(p(HGNC:PPP2CA)) |
| pmid:19401603 | p(HGNC:MAPT, pmod(Ph)) positiveCorrelation complex(GO:"tubulin complex") |
| pmid:21718217 | p(HGNC:CCL2) increases bp(GO:"microglial cell activation") |
| pmid:26837465 | p(HGNC:ESR1) association complex(GO:"neurofibrillary tangle") |
| pmid:26837465 | p(HGNC:ESR1) association complex(GO:"neurofibrillary tangle") |
| pmid:26837465 | p(HGNC:ESR1) association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:26837465 | complex(GO:"neurofibrillary tangle") association p(HGNC:ESR1) |
| pmid:26837465 | complex(GO:"neurofibrillary tangle") association p(HGNC:ESR1) |
| pmid:24368848 | complex(GO:"neurofibrillary tangle") causesNoChange act(a(MESH:Neurons)) |
| pmid:23407988 | complex(GO:"neurofibrillary tangle") decreases complex(GO:"dendritic tree") |
| pmid:10391244 | complex(GO:"neurofibrillary tangle") association complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) |
| pmid:10391244 | complex(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:CDK1) |
| pmid:12714745 | complex(GO:"neurofibrillary tangle") positiveCorrelation g(DBSNP:rs104893877) |
| pmid:26837465 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association p(HGNC:ESR1) |
| pmid:17009926 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation p(HGNC:CHRNA7) |
| pmid:17009926 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation p(HGNC:CHRNA4) |
| pmid:11230871 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(FPLX:CHRN) |
| pmid:17403556 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24401760 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:21882945 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(HBP:"Tau aggregates") |
| pmid:26458742 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(HBP:HBP00006) |
| pmid:26458742 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases tloc(p(HGNC:MAPT), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:23487739 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases a(GO:microtubule) |
| pmid:19732809 | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) |
| pmid:22040696 | path(MESH:"Neurodegenerative Diseases") association p(HGNC:CHRNA7) |
| pmid:25784053 | path(MESH:"Neurodegenerative Diseases") association path(MESH:"Protein Aggregation, Pathological") |
| pmid:29024336 | path(MESH:"Neurodegenerative Diseases") increases path(MESH:"Proteostasis Deficiencies") |
| pmid:29024336 | path(MESH:"Neurodegenerative Diseases") increases path(MESH:"Proteostasis Deficiencies") |
| pmid:24027553 | path(MESH:"Neurodegenerative Diseases") association p(HGNCGENEFAMILY:Calpains) |
| pmid:23528736 | path(MESH:"Neurodegenerative Diseases") association p(HGNC:STUB1) |
| pmid:23528736 | path(MESH:"Neurodegenerative Diseases") association p(HGNC:PRKN) |
| pmid:23528736 | path(MESH:"Neurodegenerative Diseases") association p(HGNC:RNF182) |
| pmid:23528736 | path(MESH:"Neurodegenerative Diseases") association p(HGNC:UCHL1, var("?")) |
| pmid:23528736 | path(MESH:"Neurodegenerative Diseases") association p(HGNC:ATXN3, var("?")) |
| pmid:29311797 | path(MESH:"Neurodegenerative Diseases") association bp(MESH:Aging) |
| pmid:29196815 | path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19126755 | path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | path(MESH:"Plaque, Amyloid") biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:19293145 | path(MESH:"Plaque, Amyloid") association path(MESH:"Alzheimer Disease") |
| pmid:24511233 | path(MESH:"Plaque, Amyloid") biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:24590577 | path(MESH:"Plaque, Amyloid") association path(MESH:"Alzheimer Disease") |
| pmid:25514383 | path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22817713 | path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | path(MESH:"Plaque, Amyloid") association p(HGNC:CHRNA7) |
| pmid:19293145 | path(MESH:"Plaque, Amyloid") causesNoChange r(HGNC:CHRNA4) |
| pmid:19293145 | path(MESH:"Plaque, Amyloid") causesNoChange r(HGNC:CHRNA7) |
| pmid:24511233 | path(MESH:"Plaque, Amyloid") association a(HBP:"amyloid-beta aggregates") |
| pmid:24511233 | path(MESH:"Plaque, Amyloid") increases bp(HBP:neuroinflammation) |
| pmid:24511233 | path(MESH:"Plaque, Amyloid") increases bp(GO:"cell death") |
| pmid:24590577 | path(MESH:"Plaque, Amyloid") association bp(GO:"synaptic transmission, cholinergic") |
| pmid:25514383 | path(MESH:"Plaque, Amyloid") association complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) |
| pmid:14556719 | path(MESH:"Plaque, Amyloid") association a(MESH:"Amyloid beta-Peptides") |
| pmid:24027553 | path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:MAP1LC3A) |
| pmid:28420982 | path(MESH:"Plaque, Amyloid") association a(MESH:Exosomes) |
| pmid:23531502 | path(MESH:"Plaque, Amyloid") positiveCorrelation act(a(CHEBI:acrolein)) |
| pmid:18562203 | path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) |
| pmid:26400044 | path(MESH:"Plaque, Amyloid") association complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) |
| pmid:18239272 | path(MESH:"Plaque, Amyloid") association p(HBP:"Tau epitope, AT8") |
| pmid:28877763 | path(MESH:"Plaque, Amyloid") positiveCorrelation p(MGI:Syk, pmod(Ph)) |
| pmid:28877763 | path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:SYK, pmod(Ph)) |
| pmid:24401760 | path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:ITPKB) |
| pmid:24401760 | path(MESH:"Plaque, Amyloid") partOf a(HBP:"dystrophic neurite") |
| pmid:29196815 | a(MESH:"Amyloid beta-Peptides") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22122372 | a(MESH:"Amyloid beta-Peptides") association path(MESH:"Alzheimer Disease") |
| pmid:18650430 | a(MESH:"Amyloid beta-Peptides") increases bp(GO:"cell adhesion") |
| pmid:22122372 | a(MESH:"Amyloid beta-Peptides") association a(HBP:HBP00018) |
| pmid:11230871 | a(MESH:"Amyloid beta-Peptides") negativeCorrelation p(FPLX:CHRN) |
| pmid:14556719 | a(MESH:"Amyloid beta-Peptides") association path(MESH:"Plaque, Amyloid") |
| pmid:29196815 | a(GO:"neurofibrillary tangle") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28420982 | a(GO:"neurofibrillary tangle") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22817713 | a(GO:"neurofibrillary tangle") association path(MESH:"Alzheimer Disease") |
| pmid:27671637 | a(GO:"neurofibrillary tangle") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") decreases bp(GO:cognition) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases bp(GO:"cell death") |
| pmid:30126037 | a(GO:"neurofibrillary tangle") decreases bp(GO:"cell death") |
| pmid:30126037 | a(GO:"neurofibrillary tangle") positiveCorrelation p(MGI:Cdkn2a) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases act(p(MGI:Cdkn2a)) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases p(MGI:Cdkn2a) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases p(MGI:Cdkn2a) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") association bp(GO:"cellular senescence") |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases bp(MESH:"Cell Survival") |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases bp(GO:"inflammatory response") |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases bp(GO:"cell cycle") |
| pmid:30126037 | a(GO:"neurofibrillary tangle") decreases bp(GO:"apoptotic process") |
| pmid:30126037 | a(GO:"neurofibrillary tangle") decreases path(MESH:Necrosis) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases p(HGNC:NFKB1) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases p(HGNC:IFNG) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases p(HGNC:TNF) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases p(HGNC:TLR4) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases p(HGNC:IL1B) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases p(HGNC:CXCL1) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases act(p(MGI:Ifng)) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases act(p(MGI:Tnf)) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases act(p(MGI:Il1b)) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases act(p(MGI:Jak1)) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases act(p(MGI:Stat1)) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases act(p(MGI:Bcl2)) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") association p(HGNC:CDKN2A) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:CDKN2A) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") increases p(HGNC:CDKN2A) |
| pmid:30126037 | a(GO:"neurofibrillary tangle") decreases bp(GO:"oxygen transport") |
| pmid:30126037 | a(GO:"neurofibrillary tangle") association path(MESH:"Hypertrophy, Right Ventricular") |
| pmid:30126037 | a(GO:"neurofibrillary tangle") association path(MESH:"Hypertrophy, Left Ventricular") |
| pmid:30126037 | a(GO:"neurofibrillary tangle") association path(HP:"Brain atrophy") |
| pmid:26751493 | a(GO:"neurofibrillary tangle") negativeCorrelation r(HGNC:SYP) |
| pmid:26751493 | a(GO:"neurofibrillary tangle") negativeCorrelation p(HGNC:SNAP25) |
| pmid:26751493 | a(GO:"neurofibrillary tangle") negativeCorrelation p(PFAM:Syntaxin) |
| pmid:23531502 | a(GO:"neurofibrillary tangle") positiveCorrelation act(a(CHEBI:acrolein)) |
| pmid:12578227 | a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:TGM1) |
| pmid:12578227 | a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:TGM2) |
| pmid:9099822 | a(GO:"neurofibrillary tangle") positiveCorrelation act(p(HGNC:TGM2)) |
| pmid:11089576 | a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:"2.3.2.13")) |
| pmid:11738469 | a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:"2.3.2.13")) |
| pmid:8985134 | a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:"2.3.2.13")) |
| pmid:18239272 | a(GO:"neurofibrillary tangle") association p(HBP:"Tau epitope, AT8") |
| pmid:26751493 | a(GO:"neurofibrillary tangle") negativeCorrelation p(INTERPRO:"Syntaxin, N-terminal domain") |
| pmid:26118667 | a(GO:"neurofibrillary tangle") positiveCorrelation p(HBP:"CDK5R1 p25") |
| pmid:22002427 | a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:22002427 | a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 205)) |
| pmid:29196815 | path(MESH:Smoking) increases path(MESH:"Alzheimer Disease") |
| pmid:21482353 | path(MESH:Smoking) decreases path(MESH:"Parkinson Disease") |
| pmid:29196815 | path(MESH:Obesity) increases path(MESH:"Alzheimer Disease") |
| pmid:29196815 | path(MESH:"Diabetes Mellitus") increases path(MESH:"Alzheimer Disease") |
| pmid:26195256 | path(MESH:"Diabetes Mellitus") association path(MESH:"Alzheimer Disease") |
| pmid:29626319 | path(MESH:"Diabetes Mellitus") negativeCorrelation p(HGNC:IDE) |
| pmid:29626319 | path(MESH:"Diabetes Mellitus") positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:29196815 | g(HBP:HBP00030) increases path(MESH:"Alzheimer Disease") |
| pmid:29196815 | g(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer Disease") |
| pmid:30116051 | g(HGNC:PSEN1, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26195256 | g(HGNC:PSEN1, var("?")) association path(MESH:"Alzheimer Disease") |
| pmid:30116051 | g(HGNC:PSEN1, var("?")) negativeCorrelation act(complex(GO:"lysosomal proton-transporting V-type ATPase complex")) |
| pmid:30116051 | g(HGNC:PSEN1, var("?")) negativeCorrelation bp(GO:autophagy) |
| pmid:30116051 | g(HGNC:PSEN1, var("?")) negativeCorrelation bp(GO:mitophagy) |
| pmid:29196815 | g(HGNC:PSEN2, var("?")) increases path(MESH:"Alzheimer Disease") |
| pmid:26195256 | g(HGNC:PSEN2, var("?")) association path(MESH:"Alzheimer Disease") |
| pmid:29196815 | g(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") |
| pmid:26195256 | g(HGNC:APP, var("?")) association path(MESH:"Alzheimer Disease") |
| pmid:30116051 | g(HGNC:APP, var("?")) decreases act(a(GO:endosome)) |
| pmid:30116051 | g(HGNC:APP, var("?")) decreases act(a(GO:lysosome)) |
| pmid:30116051 | g(HGNC:APP, var("?")) increases a(HBP:HBP00081) |
| pmid:29196815 | a(HBP:HBP00074) increases bp(GO:"neuron death") |
| pmid:29196815 | a(HBP:HBP00074) increases bp(GO:"neuron death") |
| pmid:29196815 | a(HBP:HBP00074) positiveCorrelation bp(GO:"neuron death") |
| pmid:21718217 | a(HBP:HBP00074) increases bp(GO:"neuron death") |
| pmid:29196815 | a(HBP:HBP00074) decreases a(MESH:Synapses) |
| pmid:29196815 | a(HBP:HBP00074) decreases a(MESH:Synapses) |
| pmid:29196815 | a(HBP:HBP00074) decreases a(MESH:Synapses) |
| pmid:29196815 | a(HBP:HBP00074) decreases bp(GO:memory) |
| pmid:29196815 | a(HBP:HBP00074) decreases bp(GO:memory) |
| pmid:29196815 | a(HBP:HBP00074) decreases bp(GO:memory) |
| pmid:29196815 | a(HBP:HBP00074) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29196815 | a(HBP:HBP00074) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29196815 | a(HBP:HBP00074) decreases bp(GO:"neuronal signal transduction") |
| pmid:29196815 | a(HBP:HBP00074) increases path(MESH:Dementia) |
| pmid:29196815 | a(HBP:HBP00074) decreases bp(GO:"long-term synaptic potentiation") |
| pmid:29196815 | a(HBP:HBP00074) decreases bp(GO:"long-term synaptic potentiation") |
| pmid:29196815 | a(HBP:HBP00074) decreases bp(GO:"signal release from synapse") |
| pmid:29196815 | a(HBP:HBP00074) increases bp(GO:"long term synaptic depression") |
| pmid:29196815 | a(HBP:HBP00074) increases p(HGNC:APP, pmod(Ph)) |
| pmid:29196815 | a(HBP:HBP00074) increases path(MESH:"Neuroaxonal Dystrophies") |
| pmid:29196815 | a(HBP:HBP00074) increases bp(GO:"microglial cell activation") |
| pmid:29196815 | a(HBP:HBP00074) increases bp(GO:"astrocyte activation") |
| pmid:29196815 | a(HBP:HBP00074) positiveCorrelation bp(GO:"astrocyte activation") |
| pmid:29196815 | a(HBP:HBP00074) positiveCorrelation a(CHEBI:"amyloid fibril") |
| pmid:29196815 | a(HBP:HBP00074) increases act(p(HGNC:GRIN1)) |
| pmid:29196815 | a(HBP:HBP00074) regulates tloc(p(HGNC:GRIA1), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29196815 | a(HBP:HBP00074) regulates tloc(p(HGNC:GRIA2), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29196815 | a(HBP:HBP00074) increases act(p(HGNC:NGFR)) |
| pmid:29196815 | a(HBP:HBP00074) decreases p(HGNC:INSR) |
| pmid:29196815 | a(HBP:HBP00074) negativeCorrelation a(CTO:"Mini_Mental_State_Examination") |
| pmid:29196815 | a(HBP:HBP00074) positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pmid:29196815 | a(HBP:HBP00074) positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pmid:21718217 | a(HBP:HBP00074) decreases bp(GO:"synaptic signaling") |
| pmid:29196815 | bp(GO:"neuron death") positiveCorrelation a(HBP:HBP00074) |
| pmid:21214928 | bp(GO:"neuron death") association complex(a(HBP:HBP00042), p(HGNC:TNFRSF21)) |
| pmid:22122372 | bp(GO:"neuron death") association path(MESH:"Alzheimer Disease") |
| pmid:17009926 | bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:17009926 | bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25514383 | bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28420982 | bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21787755 | bp(GO:"neuron death") association a(HBP:"alpha-7-containing nAChR") |
| pmid:14556719 | bp(GO:"neuron death") positiveCorrelation path(MESH:"Parkinson Disease") |
| pmid:24027553 | bp(GO:"neuron death") negativeCorrelation bp(MESH:Autophagy) |
| pmid:21882945 | bp(GO:"neuron death") positiveCorrelation path(MESH:Tauopathies) |
| pmid:28420982 | bp(GO:"neuron death") association path(MESH:Tauopathies) |
| pmid:19293145 | a(MESH:Synapses) increases bp(GO:cognition) |
| pmid:29196815 | a(CHEBI:"amyloid fibril") causesNoChange bp(GO:memory) |
| pmid:29196815 | a(CHEBI:"amyloid fibril") positiveCorrelation a(HBP:HBP00074) |
| pmid:19126755 | path(MESH:Dementia) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | path(MESH:Dementia) association path(MESH:"Alzheimer Disease") |
| pmid:24511233 | path(MESH:Dementia) association path(MESH:"Alzheimer Disease") |
| pmid:25514383 | path(MESH:Dementia) association path(MESH:"Alzheimer Disease") |
| pmid:26813123 | path(MESH:Dementia) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:25514383 | path(MESH:Dementia) association bp(GO:aging) |
| pmid:27314526 | path(MESH:Dementia) association sec(a(MESH:Interleukins)) |
| pmid:27314526 | path(MESH:Dementia) positiveCorrelation p(HGNC:IL1B) |
| pmid:27314526 | path(MESH:Dementia) positiveCorrelation p(HGNC:IL18) |
| pmid:19126755 | bp(GO:"long-term synaptic potentiation") increases bp(GO:"depolarization of postsynaptic membrane") |
| pmid:24511233 | bp(GO:"long-term synaptic potentiation") association bp(GO:learning) |
| pmid:24511233 | bp(GO:"long-term synaptic potentiation") association bp(GO:memory) |
| pmid:21787755 | bp(GO:"long-term synaptic potentiation") association a(HBP:"alpha-7-containing nAChR") |
| pmid:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:MAPT, loc(GO:synapse)) |
| pmid:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) |
| pmid:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:MAPT) |
| pmid:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(MESH:Actins, loc(GO:synapse)) |
| pmid:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(MESH:Actins) |
| pmid:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:FYN, loc(GO:synapse)) |
| pmid:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:GRIA1, loc(GO:synapse)) |
| pmid:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:GRIA1) |
| pmid:24760868 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:DLG4, loc(GO:synapse)) |
| pmid:24760868 | bp(GO:"long-term synaptic potentiation") association complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:24760868 | bp(GO:"long-term synaptic potentiation") increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:24760868 | bp(GO:"long-term synaptic potentiation") increases p(HGNC:MAPT, var("p.T205A"), loc(MESH:"Dendritic Spines")) |
| pmid:21882945 | bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:HSPB1) |
| pmid:21718217 | bp(GO:"microglial cell activation") association a(HBP:HBP00089) |
| pmid:21718217 | bp(GO:"microglial cell activation") positiveCorrelation a(HBP:HBP00089) |
| pmid:27314526 | bp(GO:"microglial cell activation") increases sec(p(HGNC:IL1B)) |
| pmid:27314526 | bp(GO:"microglial cell activation") increases sec(p(HGNC:IL6)) |
| pmid:27314526 | bp(GO:"microglial cell activation") increases sec(p(HGNC:IL18)) |
| pmid:27314526 | bp(GO:"microglial cell activation") increases sec(p(HGNC:NOS2)) |
| pmid:29196815 | bp(GO:"astrocyte activation") positiveCorrelation a(HBP:HBP00074) |
| pmid:27671637 | bp(GO:"astrocyte activation") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27314526 | bp(GO:"astrocyte activation") increases sec(p(HGNC:IL1B)) |
| pmid:27314526 | bp(GO:"astrocyte activation") increases sec(p(HGNC:IL6)) |
| pmid:27314526 | bp(GO:"astrocyte activation") increases sec(p(HGNC:IL18)) |
| pmid:27314526 | bp(GO:"astrocyte activation") increases sec(p(HGNC:NOS2)) |
| pmid:29196815 | act(p(HGNC:GRIN1)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular region"), toLoc(GO:"intracellular part")) |
| pmid:29196815 | act(p(HGNC:GRIN1)) increases bp(HBP:HBP00068) |
| pmid:29196815 | act(p(HGNC:GRIN1)) increases bp(HBP:HBP00037) |
| pmid:29196815 | act(p(HGNC:GRIN1)) decreases a(MESH:Synapses) |
| pmid:24760868 | p(HGNC:GRIA1, loc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pmid:24760868 | p(HGNC:GRIA1) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pmid:29196815 | a(HBP:HBP00075) decreases p(MGI:Adrb2) |
| pmid:29196815 | a(HBP:HBP00075) increases bp(GO:"microglial cell activation") |
| pmid:29196815 | a(HBP:HBP00075) decreases bp(GO:"long-term synaptic potentiation") |
| pmid:29196815 | complex(a(HBP:HBP00074), p(HGNC:PRNP)) decreases bp(GO:"regulation of synaptic plasticity") |
| pmid:29196815 | p(HGNC:PRNP) decreases a(CHEBI:"amyloid fibril") |
| pmid:14556719 | p(HGNC:PRNP) increases complex(a(CHEBI:"copper(2+)"), p(HGNC:PRNP)) |
| pmid:14556719 | tloc(p(HGNC:PRNP), fromLoc(MESH:"Endoplasmic Reticulum"), toLoc(GO:cytosol)) increases deg(p(HGNC:PRNP)) |
| pmid:28420982 | p(HGNC:PRNP) association a(HBP:"Tau oligomers") |
| pmid:17009926 | bp(GO:"regulation of synaptic plasticity") association p(FPLX:CHRN) |
| pmid:17009926 | bp(GO:"regulation of synaptic plasticity") association p(FPLX:CHRN) |
| pmid:24590577 | bp(GO:"regulation of synaptic plasticity") association p(HGNC:CHRM1) |
| pmid:29196815 | a(HBP:HBP00023) increases a(CHEBI:"calcium(2+)") |
| pmid:29196815 | a(HBP:HBP00023) increases complex(p(HGNC:GRIK1), p(HGNC:PRNP)) |
| pmid:29196815 | a(HBP:HBP00023) decreases bp(GO:"signal release from synapse") |
| pmid:29196815 | p(HGNC:NGFR) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29196815 | p(HGNC:NGFR) positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pmid:18986241 | p(HGNC:NGFR) association bp(GO:"GO:1901214") |
| pmid:18986241 | p(HGNC:NGFR) increases act(p(HGNC:BACE1)) |
| pmid:18986241 | p(HGNC:NGFR) increases a(CHEBI:"amyloid-beta") |
| pmid:18986241 | act(p(HGNC:NGFR)) association bp(GO:"GO:0006665") |
| pmid:18986241 | act(p(HGNC:NGFR)) increases bp(GO:"GO:0007254") |
| pmid:18986241 | act(p(HGNC:NGFR)) increases bp(GO:"GO:0038061") |
| pmid:18986241 | act(p(HGNC:NGFR)) increases bp(GO:"GO:0043491") |
| pmid:18986241 | act(p(HGNC:NGFR)) increases bp(GO:"GO:0000165") |
| pmid:22142809 | p(HGNC:NGFR) association p(HBP:RAC1b) |
| pmid:29196815 | a(CHEBI:"amyloid-beta polypeptide 42") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | a(CHEBI:"amyloid-beta polypeptide 42") association path(MESH:"Alzheimer Disease") |
| pmid:26195256 | a(CHEBI:"amyloid-beta polypeptide 42") association path(MESH:"Alzheimer Disease") |
| pmid:19126755 | a(CHEBI:"amyloid-beta polypeptide 42") association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:"amyloid-beta polypeptide 42") regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | a(CHEBI:"amyloid-beta polypeptide 42") increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:"amyloid-beta polypeptide 42") increases complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) |
| pmid:19126755 | a(CHEBI:"amyloid-beta polypeptide 42") decreases complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA7)) |
| pmid:19126755 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(HGNC:CHRNA7)) |
| pmid:19126755 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19126755 | a(CHEBI:"amyloid-beta polypeptide 42") decreases r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:25514383 | a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:"Synaptic Potentials") |
| pmid:25514383 | a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:"Synaptic Potentials") |
| pmid:25514383 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:CHRN)) |
| pmid:25514383 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:CHRN)) |
| pmid:25514383 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:25514383 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:25514383 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:25514383 | a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"long-term synaptic potentiation") |
| pmid:19721446 | a(CHEBI:"amyloid-beta polypeptide 42") increases path(HBP:neurotoxicity) |
| pmid:19721446 | a(CHEBI:"amyloid-beta polypeptide 42") increases path(HBP:neurotoxicity) |
| pmid:19721446 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(CHEBI:nicotine)) |
| pmid:19721446 | a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:Neuroprotection) |
| pmid:14556719 | a(CHEBI:"amyloid-beta polypeptide 42") increases a(HBP:"amyloid-beta fibrils") |
| pmid:30116051 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:AMPK)) |
| pmid:30116051 | a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"autophagosome assembly") |
| pmid:30116051 | a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:30116051 | a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"chaperone-mediated autophagy") |
| pmid:30116051 | a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"chaperone-mediated autophagy") |
| pmid:30116051 | a(CHEBI:"amyloid-beta polypeptide 42") decreases a(GO:microtubule) |
| pmid:30116051 | a(CHEBI:"amyloid-beta polypeptide 42") decreases p(HGNC:IDE) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:AK1) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") regulates p(HGNC:AK1) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:AK1) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") association act(p(HGNC:AK1)) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") association path(MESH:Tauopathies) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") causesNoChange p(HGNC:AK3) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases r(HGNC:AK1) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") decreases p(ECCODE:"2.7.11.31", pmod(Ph, Thr, 171)) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") causesNoChange p(ECCODE:"2.7.11.31") |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(ECCODE:"2.7.11.31")) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(ECCODE:"2.7.11.31")) |
| pmid:22419736 | a(CHEBI:"amyloid-beta polypeptide 42") decreases p(MESH:"Acetyl-CoA Carboxylase", pmod(Ph)) |
| pmid:26195256 | a(CHEBI:"amyloid-beta polypeptide 42") isA a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:TREM2) |
| pmid:29196815 | a(CTO:"Mini_Mental_State_Examination") negativeCorrelation a(HBP:HBP00074) |
| pmid:29196815 | path(MESH:"Cognitive Dysfunction") positiveCorrelation a(HBP:HBP00074) |
| pmid:29196815 | path(MESH:"Cognitive Dysfunction") positiveCorrelation a(HBP:HBP00074) |
| pmid:29196815 | path(MESH:"Cognitive Dysfunction") positiveCorrelation p(HGNC:NGFR) |
| pmid:19293145 | path(MESH:"Cognitive Dysfunction") positiveCorrelation a(HBP:"amyloid-beta oligomers") |
| pmid:19293145 | path(MESH:"Cognitive Dysfunction") association path(MESH:"Alzheimer Disease") |
| pmid:24511233 | path(MESH:"Cognitive Dysfunction") association path(MESH:"Alzheimer Disease") |
| pmid:24511233 | path(MESH:"Cognitive Dysfunction") association path(MESH:"Alzheimer Disease") |
| pmid:26813123 | path(MESH:"Cognitive Dysfunction") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24511233 | path(MESH:"Cognitive Dysfunction") association path(MESH:Schizophrenia) |
| pmid:26813123 | path(MESH:"Cognitive Dysfunction") negativeCorrelation a(GO:synapse) |
| pmid:26813123 | path(MESH:"Cognitive Dysfunction") association act(p(HGNC:CHRM1)) |
| pmid:27522251 | path(MESH:"Cognitive Dysfunction") increases path(MESH:"Plaque, Amyloid") |
| pmid:21482353 | path(MESH:"Cognitive Dysfunction") association p(HGNC:LYNX1) |
| pmid:11230871 | path(MESH:"Cognitive Dysfunction") negativeCorrelation p(FPLX:CHRN) |
| pmid:24027553 | path(MESH:"Cognitive Dysfunction") positiveCorrelation path(MESH:Tauopathies) |
| pmid:30108137 | path(MESH:"Cognitive Dysfunction") positiveCorrelation r(HGNC:TFEB) |
| pmid:30126037 | path(MESH:"Cognitive Dysfunction") association p(HGNC:CDKN2A) |
| pmid:30126037 | path(MESH:"Cognitive Dysfunction") association bp(MESH:"Cerebrovascular Circulation") |
| pmid:19765634 | path(MESH:"Cognitive Dysfunction") positiveCorrelation g(DBSNP:rs8052688) |
| pmid:19765634 | path(MESH:"Cognitive Dysfunction") positiveCorrelation g(DBSNP:rs8063) |
| pmid:29196815 | a(HBP:HBP00076) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29196815 | a(HBP:HBP00076) biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:18650430 | p(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") |
| pmid:14556719 | p(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") |
| pmid:18650430 | p(HGNC:APP, var("?")) increases path(MESH:"Cerebral Amyloid Angiopathy, Familial") |
| pmid:14556719 | p(HGNC:APP, var("?")) increases a(HBP:"amyloid-beta aggregates") |
| pmid:28420982 | path(MESH:"Cerebral Amyloid Angiopathy, Familial") association a(MESH:"Heparan Sulfate Proteoglycans") |
| pmid:18650430 | act(p(HGNC:ADAM17), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) |
| pmid:21214928 | p(HGNC:ADAM17) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) |
| pmid:22122372 | p(HGNC:ADAM17) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) |
| pmid:22122372 | p(HGNC:ADAM17) increases a(HBP:HBP00067) |
| pmid:18650430 | act(p(HGNC:ADAM9), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) |
| pmid:22122372 | p(HGNC:ADAM9) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) |
| pmid:22122372 | p(HGNC:ADAM9) increases a(HBP:HBP00067) |
| pmid:18650430 | act(p(HGNC:ADAM10), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) |
| pmid:21214928 | p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) |
| pmid:21214928 | p(HGNC:ADAM10) increases p(HBP:HBP00067) |
| pmid:21214928 | p(HGNC:ADAM10) decreases a(CHEBI:"amyloid-beta") |
| pmid:21214928 | p(HGNC:ADAM10) decreases a(CHEBI:"amyloid-beta") |
| pmid:22122372 | p(HGNC:ADAM10) decreases a(CHEBI:"amyloid-beta") |
| pmid:21214928 | p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) |
| pmid:21214928 | p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) |
| pmid:22122372 | p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) |
| pmid:22122372 | p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) |
| pmid:21214928 | p(HGNC:ADAM10) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21214928 | act(p(HGNC:ADAM10)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22122372 | p(HGNC:ADAM10) increases sec(p(HGNC:APP)) |
| pmid:24590577 | p(HGNC:ADAM10) increases deg(p(HGNC:APP)) |
| pmid:22122372 | p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067), a(HBP:HBP00072))) |
| pmid:22122372 | p(HGNC:ADAM10) increases a(HBP:HBP00067) |
| pmid:22122372 | p(HGNC:ADAM10) decreases path(MESH:"Plaque, Amyloid") |
| pmid:24590577 | p(HGNC:ADAM10) increases a(HBP:"sAPP-alpha") |
| pmid:18650430 | act(p(HGNC:BACE2), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) |
| pmid:21214928 | p(HGNC:BACE2) association rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) |
| pmid:21214928 | p(HGNC:BACE2) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) |
| pmid:18650430 | complex(FPLX:"Gamma_secretase") increases a(MESH:"Amyloid beta-Peptides") |
| pmid:18650430 | complex(FPLX:"Gamma_secretase") increases a(HBP:HBP00071) |
| pmid:22122372 | complex(FPLX:"Gamma_secretase") increases a(HBP:HBP00071) |
| pmid:21214928 | complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) |
| pmid:22122372 | complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) |
| pmid:21214928 | complex(FPLX:"Gamma_secretase") increases rxn(reactants(a(HBP:HBP00024)), products(a(CHEBI:"amyloid-beta"), a(HBP:HBP00072))) |
| pmid:21214928 | complex(FPLX:"Gamma_secretase") increases p(HBP:HBP00024, frag("?")) |
| pmid:21214928 | complex(FPLX:"Gamma_secretase") increases p(HGNC:NOTCH1, frag("?")) |
| pmid:21214928 | complex(FPLX:"Gamma_secretase") increases p(FPLX:Cadherin, frag("?")) |
| pmid:21214928 | complex(FPLX:"Gamma_secretase") increases p(HGNC:TYR, frag("?")) |
| pmid:21214928 | complex(FPLX:"Gamma_secretase") increases p(HGNC:ERBB4, frag("?")) |
| pmid:21214928 | complex(FPLX:"Gamma_secretase") increases p(HGNC:CD44, frag("?")) |
| pmid:22122372 | complex(FPLX:"Gamma_secretase") increases rxn(reactants(a(HBP:HBP00072)), products(a(HBP:HBP00071), a(HBP:HBP00080))) |
| pmid:22122372 | complex(FPLX:"Gamma_secretase") increases rxn(reactants(a(HBP:HBP00081)), products(a(HBP:HBP00071), a(MESH:"Amyloid beta-Peptides"))) |
| pmid:22122372 | complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("1_38")) |
| pmid:22122372 | complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("1_43")) |
| pmid:22122372 | complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("672_711")) |
| pmid:24590577 | complex(FPLX:"Gamma_secretase") increases deg(a(HBP:C99)) |
| pmid:24590577 | complex(FPLX:"Gamma_secretase") increases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | complex(FPLX:"Gamma_secretase") increases a(CHEBI:"amyloid-beta") |
| pmid:24590577 | complex(FPLX:"Gamma_secretase") increases a(HBP:AICD) |
| pmid:21214928 | p(HGNC:PSEN1) regulates p(HGNC:APP) |
| pmid:19293145 | p(HGNC:PSEN1) causesNoChange path(HBP:Neurodegeneration) |
| pmid:19293145 | p(HGNC:PSEN1) association path(MESH:"Alzheimer Disease") |
| pmid:24027553 | p(HGNC:PSEN1) association path(MESH:"Alzheimer disease, familial, type 3") |
| pmid:24027553 | p(HGNC:PSEN1) increases bp(GO:"vacuolar acidification") |
| pmid:21718217 | p(HGNC:APH1A) decreases p(HGNC:APP) |
| pmid:21718217 | p(HGNC:APH1A) increases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:18650430 | p(FPLX:PKC) increases sec(p(HGNC:APP)) |
| pmid:24590577 | act(p(FPLX:PKC)) increases tloc(p(HGNC:APP), fromLoc(GO:"Golgi apparatus"), toLoc(GO:"cell surface")) |
| pmid:26813123 | p(FPLX:PKC) increases p(HGNC:SLC18A3, pmod(Ph)) |
| pmid:26813123 | p(FPLX:PKC) increases p(FPLX:CHRN, pmod(Ph)) |
| pmid:24590577 | act(p(FPLX:PKC)) increases act(p(HGNC:ADAM10)) |
| pmid:24590577 | act(p(FPLX:PKC)) increases p(HGNC:BACE1) |
| pmid:24590577 | act(p(FPLX:PKC)) decreases act(p(HGNC:GSK3B)) |
| pmid:17493042 | p(FPLX:PKC) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) |
| pmid:18650430 | p(HGNC:APBA1) decreases a(CHEBI:"amyloid-beta") |
| pmid:18650430 | p(HGNC:APBA1) decreases a(HBP:HBP00018) |
| pmid:18650430 | p(HGNC:APBA1) regulates bp(HBP:HBP00073) |
| pmid:21214928 | bp(HBP:HBP00073) association p(HGNC:RAB6A) |
| pmid:22122372 | bp(HBP:HBP00073) association p(HBP:HBP00071, pmod(Ph, Thr, 654)) |
| pmid:22122372 | bp(HBP:HBP00073) association p(HBP:HBP00071, pmod(Ph, Thr, 668)) |
| pmid:22122372 | bp(HBP:HBP00073) association p(HBP:HBP00071, pmod(Ph, Ser, 665)) |
| pmid:30116051 | bp(HBP:HBP00073) association p(HGNC:LRRK2, var("?")) |
| pmid:18650430 | p(HGNC:APBA2) decreases a(CHEBI:"amyloid-beta") |
| pmid:18650430 | p(HGNC:APBA2) decreases a(HBP:HBP00018) |
| pmid:18650430 | p(HGNC:APBA2) regulates bp(HBP:HBP00073) |
| pmid:18650430 | p(HGNC:APBB1) decreases a(CHEBI:"amyloid-beta") |
| pmid:18650430 | p(HGNC:APBB1) decreases a(HBP:HBP00018) |
| pmid:18650430 | p(HGNC:APBB1) regulates bp(HBP:HBP00073) |
| pmid:18650430 | p(HGNC:APBB1) increases a(HBP:HBP00071) |
| pmid:21214928 | act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:APP) |
| pmid:21214928 | act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:GSK3B) |
| pmid:21214928 | act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:CD82) |
| pmid:21214928 | act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:MME) |
| pmid:21214928 | act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:BACE1) |
| pmid:21214928 | act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:EGFR) |
| pmid:21214928 | act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:LRP1) |
| pmid:21214928 | a(HBP:HBP00071) increases bp(GO:"apoptotic process") |
| pmid:18650430 | p(HGNC:SORL1) decreases a(CHEBI:"amyloid-beta") |
| pmid:21214928 | p(HGNC:SORL1) decreases a(CHEBI:"amyloid-beta") |
| pmid:21214928 | bp(GO:"synapse assembly") association p(HGNC:APP) |
| pmid:21214928 | bp(MESH:"Neuronal Outgrowth") association p(HGNC:APP) |
| pmid:18650430 | composite(p(HGNC:APP), p(HGNC:CNTN2)) decreases bp(GO:neurogenesis) |
| pmid:26813123 | p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) |
| pmid:26813123 | p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) |
| pmid:26813123 | p(HGNC:SLC5A7) increases a(CHEBI:choline) |
| pmid:26813123 | p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) |
| pmid:26813123 | p(HGNC:SLC5A7) increases a(CHEBI:acetylcholine) |
| pmid:17293005 | p(HGNC:BACE1, frag("67_78")) decreases sec(a(HBP:"sAPP-beta")) |
| pmid:17293005 | p(HGNC:BACE1, frag("67_78")) decreases a(HBP:"sAPP-beta") |
| pmid:17293005 | p(HGNC:BACE1, frag("67_78")) decreases sec(a(HBP:"sAPP-alpha")) |
| pmid:17293005 | p(HGNC:BACE1, frag("67_78")) increases a(HBP:"sAPP-alpha", loc(GO:intracellular)) |
| pmid:17293005 | p(HGNC:BACE1, frag("67_78")) increases a(HBP:"sAPP-alpha") |
| pmid:17293005 | p(HGNC:BACE1, frag("67_78")) causesNoChange a(CHEBI:"amyloid-beta") |
| pmid:17293005 | p(HGNC:BACE1, frag("67_78")) causesNoChange p(HGNC:ACTB) |
| pmid:17293005 | p(HGNC:BACE1, frag("67_78")) causesNoChange act(p(HGNC:BACE1)) |
| pmid:17293005 | p(HGNC:BACE1, frag("67_78")) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:17293005 | p(HGNC:BACE1, frag("69_75")) causesNoChange sec(a(HBP:"sAPP-beta")) |
| pmid:17293005 | p(HGNC:BACE1, frag("69_75")) causesNoChange sec(a(HBP:"sAPP-alpha")) |
| pmid:17293005 | p(HGNC:BACE1, frag("69_75")) causesNoChange a(CHEBI:"amyloid-beta") |
| pmid:17293005 | p(HGNC:BACE1, frag("69_75")) causesNoChange p(HGNC:ACTB) |
| pmid:17293005 | p(HGNC:BACE1, frag("228_236")) decreases sec(a(HBP:"sAPP-beta")) |
| pmid:17293005 | p(HGNC:BACE1, frag("228_236")) decreases a(HBP:"sAPP-beta") |
| pmid:17293005 | p(HGNC:BACE1, frag("228_236")) decreases sec(a(HBP:"sAPP-alpha")) |
| pmid:17293005 | p(HGNC:BACE1, frag("228_236")) increases a(HBP:"sAPP-alpha", loc(GO:intracellular)) |
| pmid:17293005 | p(HGNC:BACE1, frag("228_236")) increases a(HBP:"sAPP-alpha") |
| pmid:17293005 | p(HGNC:BACE1, frag("228_236")) causesNoChange a(CHEBI:"amyloid-beta") |
| pmid:17293005 | p(HGNC:BACE1, frag("228_236")) causesNoChange p(HGNC:ACTB) |
| pmid:17293005 | p(HGNC:BACE1, frag("228_236")) causesNoChange act(p(HGNC:BACE1)) |
| pmid:17293005 | p(HGNC:BACE1, frag("228_236")) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:17293005 | p(HGNC:BACE1, frag("230_235")) causesNoChange sec(a(HBP:"sAPP-beta")) |
| pmid:17293005 | p(HGNC:BACE1, frag("230_235")) causesNoChange sec(a(HBP:"sAPP-alpha")) |
| pmid:17293005 | p(HGNC:BACE1, frag("230_235")) causesNoChange a(CHEBI:"amyloid-beta") |
| pmid:17293005 | p(HGNC:BACE1, frag("230_235")) causesNoChange p(HGNC:ACTB) |
| pmid:21214928 | rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) association p(HGNC:BACE2) |
| pmid:21214928 | a(MESH:"Amyloid Precursor Protein Secretases") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) |
| pmid:26813123 | a(MESH:"Amyloid Precursor Protein Secretases") decreases a(MESH:"Amyloid beta-Peptides") |
| pmid:14556719 | a(MESH:"Amyloid Precursor Protein Secretases") increases rxn(reactants(p(HGNC:APP)), products(a(MESH:"Amyloid beta-Peptides"))) |
| pmid:21214928 | a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) |
| pmid:21214928 | a(MESH:Caspases) increases path(MESH:"Alzheimer Disease") |
| pmid:21214928 | a(MESH:Caspases) increases rxn(reactants(p(HBP:HBP00071)), products(a(HBP:HBP00069), a(HBP:HBP00070))) |
| pmid:21214928 | a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00069))) |
| pmid:21214928 | a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00070))) |
| pmid:22122372 | a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00069), a(HBP:HBP00070))) |
| pmid:29215007 | a(MESH:Caspases) increases p(HGNC:MAPT, var("?")) |
| pmid:21214928 | bp(HBP:HBP00077) increases p(HBP:HBP00063) |
| pmid:21214928 | bp(HBP:HBP00077) increases p(HBP:HBP00064) |
| pmid:21214928 | bp(HBP:HBP00077) increases p(HBP:HBP00065) |
| pmid:22122372 | bp(HBP:HBP00077) increases a(HBP:HBP00063) |
| pmid:22122372 | bp(HBP:HBP00077) increases a(HBP:HBP00064) |
| pmid:21214928 | p(HBP:HBP00064) association p(UNIPROT:A0A293M1A7) |
| pmid:21214928 | p(HBP:HBP00064) increases path(MESH:"Plaque, Amyloid") |
| pmid:21214928 | p(HBP:HBP00065) association p(UNIPROT:A0A293M1A7) |
| pmid:21214928 | p(HBP:HBP00065) increases path(MESH:"Plaque, Amyloid") |
| pmid:21214928 | p(HBP:HBP00065) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21214928 | p(UNIPROT:A0A293M1A7) association p(HBP:HBP00064) |
| pmid:21214928 | p(UNIPROT:A0A293M1A7) association p(HBP:HBP00065) |
| pmid:21214928 | r(HBP:HBP00064) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21214928 | a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HBP:HBP00064) |
| pmid:21214928 | a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HBP:HBP00065) |
| pmid:21214928 | a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(CHEBI:"amyloid-beta") |
| pmid:22122372 | a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(HBP:HBP00064) |
| pmid:22122372 | a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(HBP:HBP00065) |
| pmid:22122372 | a(MESH:"Receptors, N-Methyl-D-Aspartate") decreases a(HBP:HBP00063) |
| pmid:25514383 | a(MESH:"Receptors, N-Methyl-D-Aspartate") regulates tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:26751493 | a(MESH:"Receptors, N-Methyl-D-Aspartate") association p(HBP:"projection domain") |
| pmid:27796283 | a(MESH:"Receptors, N-Methyl-D-Aspartate") increases act(p(HGNC:RAC1)) |
| pmid:27796283 | a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HGNC:TIAM1, pmod(Ph)) |
| pmid:22833681 | act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases p(HBP:"Tau epitope, AT8") |
| pmid:22833681 | act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases a(HBP:"Tau epitope, PHF1") |
| pmid:22833681 | act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases a(HBP:"Tau epitope, AT180") |
| pmid:22833681 | act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) decreases a(HBP:"Tau epitope, AT100") |
| pmid:21214928 | bp(GO:"signal transduction") association p(HGNC:APP) |
| pmid:17403556 | bp(GO:"signal transduction") increases complex(a(HBP:"amyloid-beta derived diffusible ligands"), p(HGNC:MAPT)) |
| pmid:29311797 | bp(GO:"signal transduction") association p(HGNC:HSP90AB1) |
| pmid:21214928 | bp(GO:"calcium ion homeostasis") association p(HGNC:APP) |
| pmid:19293145 | bp(GO:"calcium ion homeostasis") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:21214928 | bp(GO:"protein transport") association p(HGNC:APP) |
| pmid:22122372 | complex(a(CHEBI:"amyloid-beta"), p(HGNC:APP)) regulates bp(HBP:HBP00073) |
| pmid:22122372 | complex(p(HGNC:APP), p(HGNC:SPON1)) regulates bp(HBP:HBP00073) |
| pmid:22122372 | complex(p(HGNC:APP), p(HGNC:NTN1)) regulates bp(HBP:HBP00073) |
| pmid:27068745 | p(HGNC:NTN1) decreases p(HGNC:UNC5C, var("p.Thr835Met")) |
| pmid:21214928 | p(HGNC:ITGB1) association p(HGNC:APP) |
| pmid:21214928 | bp(GO:"anterograde axonal protein transport") association p(HGNC:APP) |
| pmid:21734277 | bp(GO:"anterograde axonal protein transport") association p(HBP:"6D tau", frag("2_18")) |
| pmid:21214928 | complex(p(HGNC:APP), p(HGNC:KIF5B)) regulates act(p(HGNC:BACE1)) |
| pmid:21214928 | complex(p(HGNC:APP), p(HGNC:KIF5B)) regulates act(p(HGNC:PSEN1)) |
| pmid:19491104 | p(HGNC:KIF5B) isA complex(GO:"kinesin complex") |
| pmid:19491104 | p(HGNC:KIF5B) association complex(GO:microtubule) |
| pmid:26813123 | complex(p(HGNC:APP), p(HGNC:SLC5A7)) increases tloc(p(HGNC:APP), fromLoc(GO:"cell surface"), toLoc(GO:intracellular)) |
| pmid:21214928 | a(HBP:HBP00067) decreases bp(HBP:HBP00061) |
| pmid:22122372 | a(HBP:HBP00067) decreases bp(HBP:HBP00061) |
| pmid:22122372 | sec(a(HBP:HBP00067)) decreases bp(HBP:HBP00061) |
| pmid:21214928 | a(HBP:HBP00067) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21214928 | a(HBP:HBP00067) association bp(GO:"regulation of neuronal synaptic plasticity") |
| pmid:21214928 | a(HBP:HBP00067) regulates bp(GO:"central nervous system formation") |
| pmid:21214928 | a(HBP:HBP00067) decreases bp(HBP:HBP00068) |
| pmid:21214928 | a(HBP:HBP00067) decreases bp(HBP:HBP00068) |
| pmid:21214928 | a(HBP:HBP00067) regulates bp(GO:"stem cell proliferation") |
| pmid:21214928 | a(HBP:HBP00067) decreases act(p(HGNC:CDK5)) |
| pmid:21214928 | a(HBP:HBP00067) association complex(p(HGNC:APBA1), p(HGNC:APP)) |
| pmid:21214928 | sec(a(HBP:HBP00067)) association complex(p(HGNC:APBA1), p(HGNC:APP)) |
| pmid:21214928 | a(HBP:HBP00067) association complex(p(HGNC:APBA2), p(HGNC:APP)) |
| pmid:21214928 | sec(a(HBP:HBP00067)) association complex(p(HGNC:APBA2), p(HGNC:APP)) |
| pmid:21214928 | a(HBP:HBP00067) association complex(p(HGNC:APBA3), p(HGNC:APP)) |
| pmid:21214928 | sec(a(HBP:HBP00067)) association complex(p(HGNC:APBA3), p(HGNC:APP)) |
| pmid:21214928 | sec(a(HBP:HBP00067)) association a(CHEBI:"phorbol ester") |
| pmid:22122372 | a(HBP:HBP00067) increases bp(GO:"cell adhesion") |
| pmid:22122372 | a(HBP:HBP00067) increases bp(MESH:"Neuronal Outgrowth") |
| pmid:22122372 | a(HBP:HBP00067) increases bp(GO:"synapse assembly") |
| pmid:22122372 | a(HBP:HBP00067) increases bp(GO:learning) |
| pmid:22122372 | a(HBP:HBP00067) increases bp(GO:memory) |
| pmid:21214928 | composite(a(CHEBI:"phorbol ester"), p(HGNC:ADAM9), p(HGNC:APP)) increases a(HBP:HBP00067) |
| pmid:21214928 | a(CHEBI:"phorbol ester") association sec(a(HBP:HBP00067)) |
| pmid:21214928 | a(CHEBI:"phorbol ester") association a(CHEBI:"amyloid-beta") |
| pmid:21214928 | a(CHEBI:"phorbol ester") increases act(p(HGNC:PRKCA)) |
| pmid:21214928 | bp(GO:"regulation of neuronal synaptic plasticity") association a(HBP:HBP00067) |
| pmid:22122372 | p(HGNC:CDK5) increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) |
| pmid:22122372 | p(HGNC:CDK5) increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) |
| pmid:22122372 | p(HGNC:CDK5) increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) |
| pmid:8282104 | p(HGNC:CDK5) directlyIncreases p(HBP:HBP00053, pmod(Ph)) |
| pmid:8282104 | p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:21882945 | act(p(HGNC:CDK5)) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:27314526 | p(HGNC:CDK5) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:8282104 | p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:17078951 | act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:8282104 | p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:8282104 | p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) |
| pmid:8282104 | p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:8282104 | p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:8282104 | p(HGNC:CDK5) association a(GO:microtubule) |
| pmid:8282104 | p(HGNC:CDK5) association a(HBP:HBP00006) |
| pmid:8282104 | p(HGNC:CDK5) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(Ph)))) |
| pmid:8282104 | p(HGNC:CDK5) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21882945 | p(HGNC:CDK5) increases act(p(HGNC:MARK2)) |
| pmid:21367866 | act(p(HGNC:CDK5)) positiveCorrelation p(HGNC:CDC37) |
| pmid:27796283 | p(HGNC:CDK5) increases p(HGNC:CAMKV, pmod(Ph, Thr, 345)) |
| pmid:17078951 | act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:17078951 | act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:17078951 | act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17078951 | act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:17078951 | act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 202))) |
| pmid:17078951 | act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 212))) |
| pmid:17078951 | act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 217))) |
| pmid:17078951 | act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 404))) |
| pmid:17078951 | act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 396))) |
| pmid:8702879 | act(p(HGNC:CDK5)) increases p(HGNC:SYN1, pmod(Ph, Ser, 551)) |
| pmid:8702879 | act(p(HGNC:CDK5)) increases p(HGNC:SYN1, pmod(Ph, Ser, 553)) |
| pmid:26118667 | p(HGNC:CDK5) increases complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) |
| pmid:25001178 | act(p(HGNC:CDK5), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:25001178 | act(p(HGNC:CDK5), ma(kin)) positiveCorrelation act(p(HGNC:MAPK1), ma(kin)) |
| pmid:21214928 | complex(p(HGNC:BACE1), p(HGNC:RTN4)) decreases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) |
| pmid:21214928 | complex(p(HGNC:BACE1), p(HGNC:GGA1)) decreases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) |
| pmid:19126755 | bp(GO:"synaptic transmission, cholinergic") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") association path(MESH:"Alzheimer Disease") |
| pmid:19293145 | bp(GO:"synaptic transmission, cholinergic") association a(CHEBI:"amyloid-beta") |
| pmid:19293145 | bp(GO:"synaptic transmission, cholinergic") association a(CHEBI:"amyloid-beta") |
| pmid:24511233 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition) |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition) |
| pmid:21482353 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition) |
| pmid:24511233 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:behavior) |
| pmid:24511233 | bp(GO:"synaptic transmission, cholinergic") association path(MESH:Schizophrenia) |
| pmid:17009926 | bp(GO:"synaptic transmission, cholinergic") increases act(a(CHEBI:acetylcholine)) |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") regulates act(a(MESH:Neurons)) |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") association path(MESH:Attention) |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") increases path(MESH:Attention) |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") increases path(MESH:Attention) |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:learning) |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") positiveCorrelation bp(GO:learning) |
| pmid:21482353 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:learning) |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:memory) |
| pmid:21482353 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:memory) |
| pmid:22040696 | bp(GO:"synaptic transmission, cholinergic") increases bp(GO:memory) |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:"response to stress") |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:"regulation of circadian sleep/wake cycle, wakefulness") |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:"regulation of circadian sleep/wake cycle, sleep") |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:"sensory processing") |
| pmid:21482353 | bp(GO:"synaptic transmission, cholinergic") association bp(GO:"sensory processing") |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") regulates bp(GO:"circadian sleep/wake cycle") |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") association bp(HBP:Neurodegeneration) |
| pmid:26813123 | bp(GO:"synaptic transmission, cholinergic") association path(MESH:Dementia) |
| pmid:24590577 | bp(GO:"synaptic transmission, cholinergic") association path(MESH:"Plaque, Amyloid") |
| pmid:24590577 | bp(GO:"synaptic transmission, cholinergic") association path(MESH:"Neurofibrillary Tangles") |
| pmid:21482353 | bp(GO:"synaptic transmission, cholinergic") association path(MESH:Anxiety) |
| pmid:21482353 | bp(GO:"synaptic transmission, cholinergic") association path(MESH:Depression) |
| pmid:21482353 | bp(GO:"synaptic transmission, cholinergic") association p(HGNC:LYNX1) |
| pmid:11230871 | bp(GO:"synaptic transmission, cholinergic") association a(PUBCHEM:5662) |
| pmid:21214928 | p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00038) |
| pmid:21214928 | p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00038) |
| pmid:22122372 | p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00038) |
| pmid:21214928 | p(HGNC:APP, frag("672_713")) increases path(MESH:"Alzheimer Disease") |
| pmid:21214928 | p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00022) |
| pmid:22122372 | p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00022) |
| pmid:21214928 | p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid") |
| pmid:22122372 | p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid") |
| pmid:22122372 | p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid") |
| pmid:27094130 | sec(p(HGNC:APP, frag("672_713"))) positiveCorrelation act(p(HGNC:DAPK1), ma(kin)) |
| pmid:29540553 | p(HGNC:APP, frag("672_713")) negativeCorrelation p(MGI:Sirt3) |
| pmid:29559585 | p(HGNC:APP, frag("672_713")) increases p(MGI:Mapt, pmod(Ac)) |
| pmid:29559585 | p(HGNC:APP, frag("672_713")) increases a(CHEBI:"nitric oxide") |
| pmid:22122372 | p(HGNC:APP, frag("672_711")) decreases bp(HBP:HBP00061) |
| pmid:27094130 | sec(p(HGNC:APP, frag("672_711"))) positiveCorrelation act(p(HGNC:DAPK1), ma(kin)) |
| pmid:24401760 | p(HGNC:APP, frag("672_711")) biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:21214928 | path(MESH:"Down Syndrome") increases a(HBP:HBP00018) |
| pmid:17009926 | path(MESH:"Down Syndrome") negativeCorrelation act(p(FPLX:CHRN)) |
| pmid:17009926 | path(MESH:"Down Syndrome") negativeCorrelation p(FPLX:CHRN) |
| pmid:26813123 | path(MESH:"Down Syndrome") negativeCorrelation a(MESH:"Cholinergic Neurons") |
| pmid:21214928 | p(HGNC:CTSB) increases a(CHEBI:"amyloid-beta") |
| pmid:22122372 | p(HGNC:CTSB) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:21214928 | complex(a(HBP:HBP00042), p(HGNC:TNFRSF21)) association bp(GO:"synapse pruning") |
| pmid:21214928 | complex(a(HBP:HBP00042), p(HGNC:TNFRSF21)) association bp(GO:"neuron death") |
| pmid:21214928 | a(HBP:HBP00042) increases p(HGNC:TTR) |
| pmid:21214928 | a(HBP:HBP00042) increases p(HGNC:KL) |
| pmid:22122372 | a(HBP:HBP00042) increases bp(HBP:HBP00061) |
| pmid:21214928 | bp(GO:"synapse pruning") association complex(a(HBP:HBP00042), p(HGNC:TNFRSF21)) |
| pmid:21214928 | a(HBP:HBP00024) increases bp(HBP:HBP00027) |
| pmid:22122372 | act(p(HBP:HBP00071)) association p(HBP:HBP00071, pmod(Ph, Thr, 654)) |
| pmid:22122372 | act(p(HBP:HBP00071)) association p(HBP:HBP00071, pmod(Ph, Thr, 668)) |
| pmid:22122372 | act(p(HBP:HBP00071)) association p(HBP:HBP00071, pmod(Ph, Ser, 665)) |
| pmid:22122372 | p(HBP:HBP00071) increases bp(GO:"cell death") |
| pmid:22122372 | p(HBP:HBP00071) increases p(HGNC:TP53) |
| pmid:22122372 | p(HBP:HBP00071) increases act(p(HGNC:TP53)) |
| pmid:22122372 | p(HBP:HBP00071) regulates bp(GO:"calcium ion homeostasis") |
| pmid:22122372 | a(HBP:HBP00069) increases bp(HBP:HBP00061) |
| pmid:22122372 | a(HBP:HBP00069) increases act(p(HGNC:CASP3)) |
| pmid:22122372 | a(HBP:HBP00069) increases p(HGNC:APP, frag("672_713")) |
| pmid:22122372 | a(HBP:HBP00070) increases bp(HBP:HBP00061) |
| pmid:21214928 | complex(p(HGNC:APP), p(HGNC:NCSTN), p(HGNC:NOTCH1)) increases complex(complex(FPLX:"Gamma_secretase"), p(HGNC:APP)) |
| pmid:21214928 | p(HGNC:BSG) decreases a(CHEBI:"amyloid-beta") |
| pmid:21214928 | p(HGNC:BSG) causesNoChange a(CHEBI:"amyloid-beta") |
| pmid:21214928 | p(HGNC:TMED10) regulates a(CHEBI:"amyloid-beta") |
| pmid:21214928 | complex(a(HBP:HBP00024), complex(FPLX:"Gamma_secretase"), p(HGNC:GSAP)) increases a(CHEBI:"amyloid-beta") |
| pmid:22122372 | p(HGNC:GSK3B) increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) |
| pmid:22122372 | p(HGNC:GSK3B) increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) |
| pmid:22122372 | p(HGNC:GSK3B) increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) |
| pmid:21882945 | act(p(HGNC:GSK3B)) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29311797 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:12551948 | act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24183963 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:18494933 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29121589 | act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:10998059 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:27314526 | p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:21882945 | p(HGNC:GSK3B) increases act(p(HGNC:MARK2)) |
| pmid:11812770 | p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, frag("1_244")) |
| pmid:11812770 | p(HGNC:GSK3B) positiveCorrelation complex(p(HGNC:GSK3B), p(HGNC:MAPT)) |
| pmid:14612456 | p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:17078951 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:21734277 | act(p(HGNC:GSK3B)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:14612456 | p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:17078951 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:21734277 | act(p(HGNC:GSK3B)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:14612456 | p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:17078951 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:19459590 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:29844403 | act(p(HGNC:GSK3B)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:14612456 | p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:17078951 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:19459590 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:18494933 | act(p(HGNC:GSK3B)) negativeCorrelation bp(GO:"Wnt signaling pathway") |
| pmid:18494933 | act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:12551948 | p(HGNC:GSK3B) association p(HGNC:YWHAZ) |
| pmid:12551948 | p(HGNC:GSK3B) isA complex(p(HGNC:GSK3B), p(HGNC:MAPT), p(HGNC:YWHAZ)) |
| pmid:29121589 | p(HGNC:GSK3B) increases p(HGNC:NFE2L2, pmod(Ph)) |
| pmid:29121589 | p(HGNC:GSK3B) decreases p(HGNC:NFE2L2) |
| pmid:24355211 | p(HGNC:GSK3B) decreases p(HGNC:NFE2L2) |
| pmid:29121589 | act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:DPYSL2, pmod(Ph)) |
| pmid:7514173 | act(p(HGNC:GSK3B), ma(kin)) increases p(FPLX:CREB, pmod(Ph)) |
| pmid:7514173 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MBP, pmod(Ph)) |
| pmid:7514173 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:CSN3, pmod(Ph)) |
| pmid:7514173 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:PPP1R2, pmod(Ph)) |
| pmid:7514173 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:CSNK2B, pmod(Ph)) |
| pmid:17078951 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:17078951 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:19459590 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:21734277 | act(p(HGNC:GSK3B)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:17078951 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 217)) |
| pmid:17078951 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17078951 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:17078951 | act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 212)) |
| pmid:9089387 | act(p(HGNC:GSK3B), ma(kin)) increases p(FPLX:PDH, pmod(Ph)) |
| pmid:9089387 | p(HGNC:GSK3B) isA p(ECCODE:"2.7.11.26") |
| pmid:26501932 | p(HGNC:GSK3B) partOf a(HBP:"GVD bodies") |
| pmid:25331948 | act(p(HGNC:GSK3B), ma(kin)) increases a(HBP:"Tau epitope, PHF1") |
| pmid:25331948 | act(p(HGNC:GSK3B), ma(kin)) positiveCorrelation act(p(HGNC:SYK)) |
| pmid:28176663 | act(p(HGNC:GSK3B), ma(kin)) positiveCorrelation a(HBP:"Braak_Stage I") |
| pmid:28176663 | act(p(HGNC:GSK3B), ma(kin)) positiveCorrelation a(HBP:"Braak_Stage II") |
| pmid:28176663 | act(p(HGNC:GSK3B), ma(kin)) negativeCorrelation a(HBP:"Braak_Stage V") |
| pmid:19459590 | act(p(HGNC:GSK3B), ma(kin)) increases p(HBP:"Tau epitope, AT8") |
| pmid:24355211 | p(HGNC:GSK3B) positiveCorrelation bp(MESH:"Oxidative Stress") |
| pmid:24355211 | p(HGNC:GSK3B) negativeCorrelation bp(GO:learning) |
| pmid:24355211 | p(HGNC:GSK3B) negativeCorrelation bp(GO:memory) |
| pmid:24355211 | act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 231)) |
| pmid:24355211 | act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 235)) |
| pmid:25546293 | act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:CTNNB1, pmod(Ph, Ser, 33)) |
| pmid:25546293 | act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:CTNNB1, pmod(Ph, Ser, 37)) |
| pmid:25546293 | act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:CTNNB1, pmod(Ph, Thr, 41)) |
| pmid:21718217 | p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | act(p(HGNC:MME)) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:28250274 | p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:30116051 | p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pmid:29626319 | p(HGNC:MME) increases bp(GO:behavior) |
| pmid:28250274 | p(HGNC:MME) negativeCorrelation p(HGNC:DYRK1A) |
| pmid:26195256 | p(HGNC:LRP1) increases tloc(a(CHEBI:"amyloid-beta")) |
| pmid:26195256 | p(HGNC:LRP1) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Nephritis, Interstitial"), toLoc(MESH:Brain)) |
| pmid:26195256 | p(HGNC:LRP1) increases tloc(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:LRP1) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) |
| pmid:29626319 | p(HGNC:LRP1) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:LRP1) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:19293145 | bp(GO:"apoptotic process") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:24027553 | bp(GO:"apoptotic process") association p(HGNC:MAPT, frag("?", "17kD")) |
| pmid:24027553 | bp(GO:"apoptotic process") increases act(p(HGNC:CASP6)) |
| pmid:26304819 | bp(GO:"apoptotic process") association r(HGNC:GAPDH) |
| pmid:23948915 | bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:23948915 | bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:23948915 | bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:21214928 | complex(a(HBP:HBP00069), p(HGNC:APP)) increases bp(HBP:HBP00061) |
| pmid:22122372 | bp(GO:"neurofibrillary tangle assembly") association p(HGNC:MAPT, pmod(Ph)) |
| pmid:22122372 | bp(GO:"neurofibrillary tangle assembly") association path(MESH:"Alzheimer Disease") |
| pmid:28420982 | bp(GO:"neurofibrillary tangle assembly") association a(MESH:"Heparan Sulfate Proteoglycans") |
| pmid:19363271 | bp(GO:"neurofibrillary tangle assembly") positiveCorrelation p(SFAM:"HSP90 Family") |
| pmid:23531502 | bp(GO:"neurofibrillary tangle assembly") positiveCorrelation act(a(CHEBI:"hydrogen peroxide")) |
| pmid:26655600 | bp(GO:"neurofibrillary tangle assembly") negativeCorrelation p(HBP:"3R tau") |
| pmid:17050703 | bp(GO:"neurofibrillary tangle assembly") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) |
| pmid:16816118 | bp(GO:"neurofibrillary tangle assembly") negativeCorrelation act(p(HBP:"20 S Proteasome")) |
| pmid:22122372 | a(HBP:HBP00038) increases path(MESH:"Plaque, Amyloid") |
| pmid:21718217 | a(HBP:HBP00038) increases p(HGNC:CCL2) |
| pmid:21718217 | a(HBP:HBP00038) increases bp(GO:"microglial cell activation") |
| pmid:21718217 | act(a(HBP:HBP00038)) increases bp(GO:phagocytosis) |
| pmid:28019679 | a(HBP:HBP00038) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:24561250 | a(HBP:HBP00038) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:21718217 | a(HBP:HBP00022) decreases bp(GO:"synaptic signaling") |
| pmid:21718217 | a(HBP:HBP00022) increases bp(GO:"neuron death") |
| pmid:21214928 | bp(GO:"MAPK cascade") association a(CHEBI:"amyloid-beta") |
| pmid:19293145 | bp(GO:"MAPK cascade") increases a(CHEBI:"amyloid-beta") |
| pmid:19126755 | bp(GO:"MAPK cascade") increases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19126755 | bp(GO:"MAPK cascade") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19293145 | bp(GO:"MAPK cascade") increases act(p(HGNC:BAD)) |
| pmid:19293145 | bp(GO:"MAPK cascade") increases act(p(HGNC:MYC)) |
| pmid:19293145 | bp(GO:"MAPK cascade") increases act(p(HGNC:MYC)) |
| pmid:19293145 | bp(GO:"MAPK cascade") increases act(p(FPLX:NFkappaB)) |
| pmid:19293145 | bp(GO:"MAPK cascade") increases act(p(HGNC:NOS1)) |
| pmid:24590577 | bp(GO:"MAPK cascade") increases p(HGNC:BACE1) |
| pmid:21214928 | bp(GO:"ERK1 and ERK2 cascade") association a(CHEBI:"amyloid-beta") |
| pmid:19126755 | bp(GO:"ERK1 and ERK2 cascade") increases act(a(CHEBI:nicotine)) |
| pmid:19293145 | bp(GO:"ERK1 and ERK2 cascade") increases bp(GO:"apoptotic process") |
| pmid:24590577 | bp(GO:"ERK1 and ERK2 cascade") regulates act(p(HGNC:ADAM10)) |
| pmid:24590577 | bp(GO:"ERK1 and ERK2 cascade") regulates bp(HBP:"APP processing") |
| pmid:27594586 | bp(GO:"ERK1 and ERK2 cascade") regulates p(HGNC:MMP9) |
| pmid:21214928 | complex(a(CHEBI:"amyloid-beta"), p(HGNC:DNM1)) decreases bp(HBP:HBP00061) |
| pmid:19721446 | p(HGNC:DNM1) association p(HGNC:CHRNB2) |
| pmid:29590627 | act(p(HGNC:DNM1)) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | act(p(HGNC:DNM1)) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | act(p(HGNC:DNM1)) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:21214928 | bp(MESH:"Synaptic Transmission") association a(CHEBI:"amyloid-beta") |
| pmid:26813123 | bp(MESH:"Synaptic Transmission") association bp(GO:memory) |
| pmid:14556719 | bp(MESH:"Synaptic Transmission") association p(HGNC:PRKN) |
| pmid:21214928 | a(MESH:"Potassium Channels") association a(CHEBI:"amyloid-beta") |
| pmid:14556719 | bp(GO:"cell death") positiveCorrelation p(HGNC:GPR37) |
| pmid:24561250 | bp(GO:"cell death") increases sec(a(CHEBI:ATP)) |
| pmid:21214928 | complex(p(HGNC:APBA1), p(HGNC:APP)) regulates bp(GO:"protein transport") |
| pmid:21214928 | complex(p(HGNC:APBA1), p(HGNC:APP)) association a(HBP:HBP00067) |
| pmid:21214928 | complex(p(HGNC:APBA1), p(HGNC:APP)) association sec(a(HBP:HBP00067)) |
| pmid:21214928 | complex(p(HGNC:APBA1), p(HGNC:APP)) association a(CHEBI:"amyloid-beta") |
| pmid:21214928 | complex(p(HGNC:APBA1), p(HGNC:APP)) association sec(a(CHEBI:"amyloid-beta")) |
| pmid:21214928 | complex(p(HGNC:APBA2), p(HGNC:APP)) regulates bp(GO:"protein transport") |
| pmid:21214928 | complex(p(HGNC:APBA2), p(HGNC:APP)) association a(HBP:HBP00067) |
| pmid:21214928 | complex(p(HGNC:APBA2), p(HGNC:APP)) association sec(a(HBP:HBP00067)) |
| pmid:21214928 | complex(p(HGNC:APBA2), p(HGNC:APP)) association a(CHEBI:"amyloid-beta") |
| pmid:21214928 | complex(p(HGNC:APBA2), p(HGNC:APP)) association sec(a(CHEBI:"amyloid-beta")) |
| pmid:21214928 | complex(p(HGNC:APBA3), p(HGNC:APP)) regulates bp(GO:"protein transport") |
| pmid:21214928 | complex(p(HGNC:APBA3), p(HGNC:APP)) association a(HBP:HBP00067) |
| pmid:21214928 | complex(p(HGNC:APBA3), p(HGNC:APP)) association sec(a(HBP:HBP00067)) |
| pmid:21214928 | complex(p(HGNC:APBA3), p(HGNC:APP)) association a(CHEBI:"amyloid-beta") |
| pmid:21214928 | complex(p(HGNC:APBA3), p(HGNC:APP)) association sec(a(CHEBI:"amyloid-beta")) |
| pmid:21214928 | p(HGNC:RAB6A) association bp(HBP:HBP00073) |
| pmid:21214928 | bp(GO:"clathrin-dependent endocytosis") increases deg(p(HGNC:APP)) |
| pmid:26751493 | bp(GO:"clathrin-dependent endocytosis") positiveCorrelation p(HGNC:MAPT) |
| pmid:26751493 | bp(GO:"clathrin-dependent endocytosis") isA tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) |
| pmid:27260836 | bp(GO:"clathrin-dependent endocytosis") positiveCorrelation complex(p(HBP:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) |
| pmid:21214928 | complex(p(HGNC:PLD1), p(HGNC:PSEN1)) increases p(HGNC:APP) |
| pmid:21214928 | complex(p(HGNC:APP), p(HGNC:LRP1)) decreases p(HGNC:APP) |
| pmid:21214928 | complex(p(HGNC:APP), p(HGNC:LRP1)) increases a(CHEBI:"amyloid-beta") |
| pmid:21214928 | complex(p(HGNC:APP), p(HGNC:LRP1B)) decreases a(CHEBI:"amyloid-beta") |
| pmid:21214928 | complex(p(HGNC:APP), p(HGNC:LRP1B)) increases sec(a(HBP:HBP00067)) |
| pmid:21214928 | a(CHEBI:estrogen) decreases a(CHEBI:"amyloid-beta") |
| pmid:19293145 | a(CHEBI:estrogen) decreases act(a(CHEBI:"amyloid-beta")) |
| pmid:11230871 | a(CHEBI:estrogen) decreases act(a(CHEBI:"amyloid-beta")) |
| pmid:21214928 | a(CHEBI:estrogen) increases sec(a(HBP:HBP00067)) |
| pmid:19293145 | a(CHEBI:estrogen) decreases act(p(HBP:"APOE e4")) |
| pmid:11230871 | a(CHEBI:estrogen) decreases path(MESH:"Alzheimer Disease") |
| pmid:21214928 | act(p(HGNC:PRKCA)) increases sec(a(HBP:HBP00067)) |
| pmid:21214928 | p(HGNC:PRKCA) increases sec(a(HBP:HBP00067)) |
| pmid:21214928 | p(HGNC:PRKCA) decreases a(CHEBI:"amyloid-beta") |
| pmid:21214928 | p(HGNC:PRKCA) directlyIncreases p(HGNC:APP, pmod(Ph, Ser, 655)) |
| pmid:22122372 | p(HGNC:PRKCA) increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) |
| pmid:22122372 | p(HGNC:PRKCA) increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) |
| pmid:22122372 | p(HGNC:PRKCA) increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) |
| pmid:21214928 | p(HGNC:PRKACA) decreases a(CHEBI:"amyloid-beta") |
| pmid:8282104 | p(HGNC:PRKACA) association a(GO:microtubule) |
| pmid:8282104 | p(HGNC:PRKACA) association a(HBP:HBP00006) |
| pmid:21214928 | p(HGNC:RAB11A) decreases a(CHEBI:"amyloid-beta") |
| pmid:21214928 | a(CHEBI:testosterone) decreases path(MESH:"Plaque, Amyloid") |
| pmid:21214928 | a(CHEBI:testosterone) decreases r(HGNC:BACE1) |
| pmid:21214928 | a(CHEBI:testosterone) decreases p(HGNC:BACE1) |
| pmid:21214928 | a(CHEBI:testosterone) decreases act(p(HGNC:BACE1)) |
| pmid:21214928 | a(CHEBI:testosterone) decreases p(HGNC:PSEN1) |
| pmid:22122372 | a(HBP:HBP00064) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22122372 | a(HBP:HBP00078) association p(HGNC:APP) |
| pmid:22122372 | a(HBP:HBP00078) increases complex(p(HGNC:APP), p(HGNC:APP)) |
| pmid:22122372 | a(HBP:HBP00078) increases complex(p(HGNC:APLP1), p(HGNC:APLP1)) |
| pmid:22122372 | a(HBP:HBP00078) increases complex(p(HGNC:APLP2), p(HGNC:APLP2)) |
| pmid:22122372 | a(HBP:HBP00079) association p(HGNC:APP) |
| pmid:22122372 | a(HBP:HBP00065) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22122372 | composite(p(MGI:Aplp1), p(MGI:Aplp2), p(MGI:App)) decreases path(MESH:"Perinatal Death") |
| pmid:29221819 | p(MGI:App) negativeCorrelation p(MGI:Dyrk1a) |
| pmid:22122372 | p(HGNC:PSEN1, var("?")) increases p(HGNC:APP, frag("672_713")) |
| pmid:14556719 | p(HGNC:PSEN1, var("?")) association act(complex(GO:"gamma-secretase complex")) |
| pmid:14556719 | p(HGNC:PSEN1, var("?")) increases a(CHEBI:"amyloid-beta") |
| pmid:22122372 | p(HGNC:PSEN2, var("?")) increases p(HGNC:APP, frag("672_713")) |
| pmid:14556719 | p(HGNC:PSEN2, var("?")) association act(complex(GO:"gamma-secretase complex")) |
| pmid:14556719 | p(HGNC:PSEN2, var("?")) increases a(CHEBI:"amyloid-beta") |
| pmid:22122372 | a(MESH:"Receptors, Cell Surface") association p(HGNC:APP) |
| pmid:22122372 | complex(p(HGNC:APP), p(HGNC:RTN4R)) regulates bp(HBP:HBP00073) |
| pmid:22122372 | complex(p(HGNC:APP), p(HGNC:ITM2B)) regulates bp(HBP:HBP00073) |
| pmid:22122372 | complex(a(HBP:HBP00078), a(HBP:HBP00079)) increases complex(p(HGNC:APLP1), p(HGNC:APP)) |
| pmid:22122372 | complex(a(HBP:HBP00078), a(HBP:HBP00079)) increases complex(p(HGNC:APLP2), p(HGNC:APP)) |
| pmid:22122372 | complex(a(HBP:HBP00078), a(HBP:HBP00079)) increases complex(p(HGNC:APP), p(HGNC:APP)) |
| pmid:22122372 | complex(p(HBP:HBP00042, frag("?")), p(HGNC:TNFRSF21)) increases bp(GO:"neuron death") |
| pmid:22122372 | complex(p(HBP:HBP00042, frag("?")), p(HGNC:TNFRSF21)) increases bp(GO:"synapse pruning") |
| pmid:19491104 | act(p(HGNC:KLC1)) positiveCorrelation act(complex(GO:"kinesin complex")) |
| pmid:19491104 | p(HGNC:KLC1) isA complex(GO:"kinesin complex") |
| pmid:19491104 | p(HGNC:KLC1) association p(HGNC:MAPK8IP1) |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:APBA1)) decreases a(CHEBI:"amyloid-beta") |
| pmid:22122372 | p(HBP:HBP00071, pmod(Ph, Thr, 654)) association bp(HBP:HBP00073) |
| pmid:22122372 | p(HBP:HBP00071, pmod(Ph, Thr, 654)) association act(p(HBP:HBP00071)) |
| pmid:22122372 | p(HBP:HBP00071, pmod(Ph, Thr, 668)) association bp(HBP:HBP00073) |
| pmid:22122372 | p(HBP:HBP00071, pmod(Ph, Thr, 668)) association act(p(HBP:HBP00071)) |
| pmid:22122372 | p(HBP:HBP00071, pmod(Ph, Ser, 665)) association bp(HBP:HBP00073) |
| pmid:22122372 | p(HBP:HBP00071, pmod(Ph, Ser, 665)) association act(p(HBP:HBP00071)) |
| pmid:22122372 | p(HGNC:CAMK2A) increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) |
| pmid:22122372 | p(HGNC:CAMK2A) increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) |
| pmid:22122372 | p(HGNC:CAMK2A) increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) |
| pmid:22122372 | a(MESH:"JNK Mitogen-Activated Protein Kinases") increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) |
| pmid:22122372 | a(MESH:"JNK Mitogen-Activated Protein Kinases") increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) |
| pmid:22122372 | a(MESH:"JNK Mitogen-Activated Protein Kinases") increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:CD82) |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:MME) |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:TP53) |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:GSK3B) |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:EGFR) |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:LRP1) |
| pmid:22122372 | act(p(HGNC:TP53)) increases bp(GO:"apoptotic process") |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:TFCP2)) increases p(HGNC:GSK3B) |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:MAPK8IP1)) regulates p(HGNC:APP, pmod(Ph, Thr, 668)) |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:MAPK8IP1)) association a(HBP:HBP00073) |
| pmid:19491104 | act(p(HGNC:MAPK8IP1)) positiveCorrelation act(complex(GO:"kinesin complex")) |
| pmid:19491104 | p(HGNC:MAPK8IP1) isA complex(GO:"kinesin complex") |
| pmid:19491104 | p(HGNC:MAPK8IP1) association p(HGNC:KLC1) |
| pmid:27094130 | p(HGNC:APP, pmod(Ph, Thr, 668)) regulates sec(p(HGNC:APP, frag("672_711"))) |
| pmid:27094130 | p(HGNC:APP, pmod(Ph, Thr, 668)) regulates sec(p(HGNC:APP, frag("672_713"))) |
| pmid:22122372 | a(HBP:HBP00073) association complex(p(HBP:HBP00071), p(HGNC:MAPK8IP1)) |
| pmid:30116051 | act(p(HGNC:CASP3)) increases p(HGNC:BECN1, frag("?")) |
| pmid:24027553 | act(p(HGNC:CASP3)) increases p(HGNC:MAPT, frag("?_*")) |
| pmid:24027553 | act(p(HGNC:CASP3)) increases deg(p(HGNC:MAPT)) |
| pmid:29238289 | act(p(HGNC:CASP3)) increases p(HGNC:MAPT) |
| pmid:24027553 | act(p(HGNC:CASP3)) increases p(HBP:"Tau C3") |
| pmid:24027553 | act(p(HGNC:CASP3)) increases p(HBP:"Tau C3") |
| pmid:24027553 | act(p(HGNC:CASP3)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27068745 | p(HGNC:CASP3) association act(p(FPLX:JNK)) |
| pmid:27068745 | p(HGNC:CASP3) association act(p(HGNC:MAP3K5)) |
| pmid:27068745 | p(HGNC:CASP3) increases bp(GO:"neuron apoptotic process") |
| pmid:27314526 | act(p(HGNC:CASP3)) increases bp(GO:"neuron death") |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:NAE1)) increases bp(GO:"protein neddylation") |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:NAE1)) decreases p(HGNC:CTNNB1) |
| pmid:22122372 | complex(p(HBP:HBP00071), p(HGNC:NAE1)) increases bp(GO:"apoptotic process") |
| pmid:18494933 | deg(p(HGNC:CTNNB1)) positiveCorrelation p(HGNC:DKK1) |
| pmid:19126755 | a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) |
| pmid:24590577 | a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) |
| pmid:19126755 | a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:24590577 | a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:acetylcholine) decreases path(MESH:"Heart Rate") |
| pmid:19126755 | a(CHEBI:acetylcholine) association bp(GO:signaling) |
| pmid:24511233 | a(CHEBI:acetylcholine) regulates act(a(MESH:Neurons)) |
| pmid:24511233 | act(a(CHEBI:acetylcholine)) increases act(p(HGNC:CHRM1)) |
| pmid:17009926 | deg(a(CHEBI:acetylcholine)) decreases act(a(CHEBI:acetylcholine)) |
| pmid:17009926 | a(CHEBI:acetylcholine) increases act(p(HGNC:CHRNA7)) |
| pmid:17009926 | a(CHEBI:acetylcholine) increases bp(GO:"regulation of action potential firing rate") |
| pmid:26813123 | a(CHEBI:acetylcholine) isA a(CHEBI:neurotransmitter) |
| pmid:26813123 | a(CHEBI:acetylcholine) positiveCorrelation bp(GO:memory) |
| pmid:26813123 | a(CHEBI:acetylcholine) regulates bp(GO:memory) |
| pmid:26813123 | a(CHEBI:acetylcholine) association bp(GO:memory) |
| pmid:26813123 | a(CHEBI:acetylcholine) regulates a(MESH:"Hypothalamo-Hypophyseal System") |
| pmid:26813123 | a(CHEBI:acetylcholine) increases act(a(MESH:"Receptors, Nicotinic")) |
| pmid:26813123 | a(CHEBI:acetylcholine) increases bp(GO:"synaptic transmission, cholinergic") |
| pmid:26813123 | a(CHEBI:acetylcholine) increases bp(GO:neurogenesis) |
| pmid:26813123 | a(CHEBI:acetylcholine) increases act(p(FPLX:CHRM)) |
| pmid:21482353 | a(CHEBI:acetylcholine) increases act(p(FPLX:CHRM)) |
| pmid:26813123 | a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN)) |
| pmid:21482353 | a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN)) |
| pmid:21787755 | a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN)) |
| pmid:26813123 | deg(a(CHEBI:acetylcholine)) increases a(CHEBI:choline) |
| pmid:26813123 | a(CHEBI:acetylcholine) regulates bp(MESH:"Synaptic Transmission") |
| pmid:26813123 | a(CHEBI:acetylcholine) regulates bp(GO:"synaptic transmission, glutamatergic") |
| pmid:26813123 | a(CHEBI:acetylcholine) association bp(GO:learning) |
| pmid:26813123 | a(CHEBI:acetylcholine) association bp(GO:cognition) |
| pmid:11230871 | a(CHEBI:acetylcholine) negativeCorrelation bp(GO:cognition) |
| pmid:16273023 | a(CHEBI:acetylcholine) increases complex(a(CHEBI:acetylcholine), p(MESH:D011950)) |
| pmid:25514383 | tloc(a(CHEBI:acetylcholine), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) regulates bp(GO:"long-term memory") |
| pmid:25514383 | a(CHEBI:acetylcholine) increases act(a(HBP:"beta-2-containing nAChR")) |
| pmid:25514383 | act(a(CHEBI:acetylcholine)) increases act(a(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:21482353 | a(CHEBI:acetylcholine) increases act(a(HBP:"alpha-7-containing nAChR")) |
| pmid:19721446 | a(CHEBI:acetylcholine) association bp(GO:"regulation of cation channel activity") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates p(FPLX:PLC) |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"3',5'-cyclic AMP") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"myo-inositol trisphosphate") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"calcium ion") |
| pmid:24511233 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") regulates act(a(CHEBI:acetylcholine)) |
| pmid:19721446 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") increases act(a(CHEBI:acetylcholine)) |
| pmid:24511233 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") isA p(MESH:"Receptors, G-Protein-Coupled") |
| pmid:24511233 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") regulates bp(GO:cognition) |
| pmid:24590577 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:"Alzheimer Disease") |
| pmid:24590577 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association bp(GO:memory) |
| pmid:24590577 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:Attention) |
| pmid:24590577 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:Nociception) |
| pmid:24590577 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association bp(GO:"circadian sleep/wake cycle") |
| pmid:24590577 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association a(MESH:"Cardiovascular System") |
| pmid:24590577 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association a(MESH:Kidney) |
| pmid:24590577 | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association a(MESH:"Gastrointestinal Tract") |
| pmid:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Electric Fish") |
| pmid:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") decreases bp(GO:"response to nicotine") |
| pmid:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") isA p(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors") |
| pmid:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases sec(a(CHEBI:"gamma-aminobutyric acid")) |
| pmid:19721446 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(CHEBI:"gamma-aminobutyric acid")) |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"synaptic transmission, dopaminergic") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association path(MESH:"Alzheimer Disease") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation path(MESH:Schizophrenia) |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation a(CHEBI:"kynurenic acid") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:anandamide) |
| pmid:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:anandamide) |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"cation transport") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases a(MESH:Sodium, loc(GO:intracellular)) |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"membrane depolarization") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"positive regulation of voltage-gated calcium channel activity") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) |
| pmid:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates bp(GO:"inflammatory response") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases bp(GO:"keratinocyte migration") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"phosphatidylinositol 3-kinase signaling") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"ERK1 and ERK2 cascade") |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"receptor signaling pathway via JAK-STAT") |
| pmid:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Mice, Inbred Strains") |
| pmid:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Mice, Inbred Strains") |
| pmid:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Rats, Inbred Strains") |
| pmid:19126755 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") negativeCorrelation path(MESH:Aging) |
| pmid:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:"amyloid-beta") |
| pmid:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:"amyloid-beta") |
| pmid:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates sec(a(CHEBI:"amyloid-beta")) |
| pmid:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates act(a(CHEBI:"amyloid-beta")) |
| pmid:19293145 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:"amyloid-beta") |
| pmid:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") decreases path(HBP:neurotoxicity) |
| pmid:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association path(HBP:neurotoxicity) |
| pmid:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:nicotine) |
| pmid:19293145 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases act(a(CHEBI:"N-methyl-4-phenylpyridinium")) |
| pmid:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases bp(MESH:Neuroprotection) |
| pmid:19293145 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(FPLX:PI3K)) |
| pmid:19293145 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association p(HGNC:JAK2) |
| pmid:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association bp(GO:"calcium ion homeostasis") |
| pmid:19293145 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association g(HGNC:APOE) |
| pmid:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association p(HGNC:APOE) |
| pmid:19293145 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(HBP:"sAPP-beta")) |
| pmid:19293145 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association bp(GO:"apoptotic process") |
| pmid:19293145 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24511233 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates act(a(CHEBI:acetylcholine)) |
| pmid:19721446 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases act(a(CHEBI:acetylcholine)) |
| pmid:19721446 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Peripheral Nervous System") |
| pmid:19721446 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Central Nervous System") |
| pmid:19721446 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(CHEBI:dopamine)) |
| pmid:19721446 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(CHEBI:serotonin)) |
| pmid:19721446 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(CHEBI:"glutamate(2-)")) |
| pmid:19721446 | act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:cholesterol) |
| pmid:19721446 | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates bp(MESH:"Sensory Gating") |
| pmid:19126755 | a(TAXONOMY:41956) increases a(CHEBI:Muscarine) |
| pmid:19126755 | a(CHEBI:Muscarine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) |
| pmid:19126755 | a(TAXONOMY:33113) increases a(CHEBI:atropine) |
| pmid:19126755 | a(CHEBI:atropine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) |
| pmid:19126755 | a(CHEBI:atropine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) |
| pmid:19126755 | a(CHEBI:atropine) decreases bp(GO:"cell adhesion") |
| pmid:26813123 | a(CHEBI:atropine) decreases act(p(FPLX:CHRM)) |
| pmid:26751493 | p(FPLX:PLC) association p(HBP:"projection domain") |
| pmid:26751493 | p(FPLX:PLC) association a(HBP:"projection domain") |
| pmid:29626319 | a(CHEBI:"3',5'-cyclic AMP") increases deg(p(HGNC:MAPT)) |
| pmid:19126755 | a(CHEBI:nicotine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:nicotine) decreases deg(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(GO:"endoplasmic reticulum"))) |
| pmid:19126755 | a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | a(CHEBI:nicotine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:nicotine) causesNoChange p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | a(CHEBI:nicotine) regulates p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | a(CHEBI:nicotine) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | a(CHEBI:nicotine) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19293145 | a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19721446 | a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19721446 | act(a(CHEBI:nicotine)) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:nicotine) causesNoChange a(MESH:Manduca) |
| pmid:19126755 | a(CHEBI:nicotine) association path(HBP:neurotoxicity) |
| pmid:19293145 | a(CHEBI:nicotine) decreases path(HBP:neurotoxicity) |
| pmid:19126755 | a(CHEBI:nicotine) increases p(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19126755 | a(CHEBI:nicotine) increases p(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19126755 | a(CHEBI:nicotine) increases p(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19126755 | a(CHEBI:nicotine) decreases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19126755 | a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19126755 | a(CHEBI:nicotine) increases a(HBP:"alpha-3 beta-2 nAChR") |
| pmid:18174175 | a(CHEBI:nicotine) increases a(HBP:"alpha-3 beta-2 nAChR") |
| pmid:19126755 | a(CHEBI:nicotine) increases a(HBP:"alpha-3 beta-4 nAChR") |
| pmid:19126755 | a(CHEBI:nicotine) decreases complex(p(HGNC:CHRNA6), p(HGNC:CHRNB3)) |
| pmid:19126755 | a(CHEBI:nicotine) increases act(p(FPLX:PI3K)) |
| pmid:19293145 | a(CHEBI:nicotine) increases act(p(FPLX:PI3K)) |
| pmid:19126755 | a(CHEBI:nicotine) increases act(p(FPLX:PKA)) |
| pmid:19126755 | a(CHEBI:nicotine) increases act(p(FPLX:PKC)) |
| pmid:19126755 | a(CHEBI:nicotine) increases act(p(FPLX:"CAMK2_complex")) |
| pmid:19126755 | act(a(CHEBI:nicotine)) increases act(p(FPLX:CREB)) |
| pmid:19126755 | act(a(CHEBI:nicotine)) increases act(p(HGNC:ATF2)) |
| pmid:19126755 | act(a(CHEBI:nicotine)) increases act(p(RGD:Elk1)) |
| pmid:19126755 | act(a(CHEBI:nicotine)) increases act(p(HGNC:STAT3)) |
| pmid:19293145 | act(a(CHEBI:nicotine)) association act(p(HGNC:STAT3)) |
| pmid:19126755 | act(a(CHEBI:nicotine)) association a(MESH:Skin) |
| pmid:19126755 | act(a(CHEBI:nicotine)) regulates bp(GO:"inflammatory response") |
| pmid:23178521 | a(CHEBI:nicotine) regulates bp(GO:"inflammatory response") |
| pmid:19126755 | a(CHEBI:nicotine) decreases path(MESH:"Colitis, Ulcerative") |
| pmid:19126755 | a(CHEBI:nicotine) decreases path(MESH:"Inflammatory Bowel Diseases") |
| pmid:19126755 | a(CHEBI:nicotine) decreases sec(p(HGNC:TNF)) |
| pmid:19293145 | a(CHEBI:nicotine) regulates act(p(HGNC:TNF)) |
| pmid:19126755 | act(a(CHEBI:nicotine)) association path(MESH:"Genetic Variation") |
| pmid:19126755 | a(CHEBI:nicotine) causesNoChange path(MESH:"Alzheimer Disease") |
| pmid:19126755 | a(CHEBI:nicotine) causesNoChange p(MGI:Chrna4) |
| pmid:19126755 | a(CHEBI:nicotine) decreases act(a(CHEBI:"NS-398")) |
| pmid:19126755 | a(CHEBI:nicotine) decreases bp(GO:"neuron death") |
| pmid:19126755 | a(CHEBI:nicotine) decreases bp(GO:"neuron death") |
| pmid:19126755 | a(CHEBI:nicotine) increases sec(a(CHEBI:dopamine)) |
| pmid:17009926 | a(CHEBI:nicotine) decreases sec(a(CHEBI:dopamine)) |
| pmid:21482353 | a(CHEBI:nicotine) decreases a(CHEBI:dopamine) |
| pmid:21482353 | a(CHEBI:nicotine) increases tloc(a(CHEBI:dopamine), fromLoc(MESH:"Presynaptic Terminals"), toLoc(GO:"extracellular region")) |
| pmid:19721446 | a(CHEBI:nicotine) regulates sec(a(CHEBI:dopamine)) |
| pmid:19126755 | a(CHEBI:nicotine) increases path(MESH:"Behavior, Addictive") |
| pmid:19126755 | a(CHEBI:nicotine) increases path(MESH:Craving) |
| pmid:19126755 | a(CHEBI:nicotine) increases path(MESH:Anxiety) |
| pmid:19126755 | a(CHEBI:nicotine) association act(p(HGNC:CHRNA7)) |
| pmid:19293145 | act(a(CHEBI:nicotine)) increases p(HGNC:CHRNA7) |
| pmid:17009926 | a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7)) |
| pmid:26472524 | a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7)) |
| pmid:19126755 | a(CHEBI:nicotine) association a(HBP:"beta-2-containing nAChR") |
| pmid:19293145 | a(CHEBI:nicotine) increases bp(MESH:Neuroprotection) |
| pmid:19293145 | act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection) |
| pmid:19293145 | act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection) |
| pmid:19293145 | act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection) |
| pmid:19293145 | a(CHEBI:nicotine) increases bp(MESH:Neuroprotection) |
| pmid:19721446 | a(CHEBI:nicotine) association bp(MESH:Neuroprotection) |
| pmid:19293145 | a(CHEBI:nicotine) increases a(CHEBI:acetylcholine) |
| pmid:19293145 | a(CHEBI:nicotine) increases complex(a(MESH:Bungarotoxins), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | a(CHEBI:nicotine) decreases act(a(CHEBI:thapsigargin)) |
| pmid:19293145 | act(a(CHEBI:nicotine)) decreases act(a(CHEBI:methamphetamine)) |
| pmid:19293145 | a(CHEBI:nicotine) association bp(GO:"negative regulation of apoptotic process") |
| pmid:19293145 | act(a(CHEBI:nicotine)) increases p(FPLX:AKT, pmod(Ph)) |
| pmid:19293145 | act(a(CHEBI:nicotine)) increases p(HGNC:BCL2) |
| pmid:19293145 | act(a(CHEBI:nicotine)) increases p(HGNC:BCL2L1) |
| pmid:19293145 | a(CHEBI:nicotine) increases p(HGNC:BAX, pmod(Ph)) |
| pmid:19293145 | a(CHEBI:nicotine) decreases bp(GO:"apoptotic process") |
| pmid:19293145 | a(CHEBI:nicotine) decreases bp(GO:"apoptotic process") |
| pmid:25514383 | a(CHEBI:nicotine) decreases bp(GO:"apoptotic process") |
| pmid:19293145 | a(CHEBI:nicotine) decreases tloc(p(HGNC:BAX), fromLoc(GO:cytosol), toLoc(GO:mitochondrion)) |
| pmid:19293145 | a(CHEBI:nicotine) increases act(p(HGNC:BAD)) |
| pmid:19293145 | a(CHEBI:nicotine) increases complex(p(FPLX:"PI3K_p85"), p(HGNC:CHRNA7), p(HGNC:FYN)) |
| pmid:19293145 | act(a(CHEBI:nicotine)) increases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:nicotine) association p(HGNC:STAT3, pmod(Ph)) |
| pmid:19293145 | act(a(CHEBI:nicotine)) increases p(RGD:Mapk3, pmod(Ph)) |
| pmid:19293145 | act(a(CHEBI:nicotine)) increases p(RGD:Mapk14, pmod(Ph)) |
| pmid:19293145 | act(a(CHEBI:nicotine)) increases p(RGD:Stat3, pmod(Ph)) |
| pmid:19293145 | a(CHEBI:nicotine) increases act(g(HGNC:NIN)) |
| pmid:19293145 | a(CHEBI:nicotine) increases act(g(HGNC:PTGS2)) |
| pmid:19293145 | a(CHEBI:nicotine) increases a(CHEBI:"prostaglandin E1(1-)") |
| pmid:19293145 | a(CHEBI:nicotine) increases bp(GO:"ERK1 and ERK2 cascade") |
| pmid:19293145 | a(CHEBI:nicotine) increases bp(GO:"MAPK cascade") |
| pmid:19293145 | act(a(CHEBI:nicotine)) increases composite(p(FPLX:JAK), p(HGNC:STAT3)) |
| pmid:19293145 | a(CHEBI:nicotine) decreases act(a(CHEBI:"N-methyl-D-aspartic acid")) |
| pmid:19293145 | a(CHEBI:nicotine) decreases a(MESH:Lipopolysaccharides) |
| pmid:19293145 | a(CHEBI:nicotine) association bp(GO:"calcium-mediated signaling") |
| pmid:19293145 | a(CHEBI:nicotine) association p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors") |
| pmid:19293145 | a(CHEBI:nicotine) association p(HGNCGENEFAMILY:"Ryanodine receptors") |
| pmid:19293145 | a(CHEBI:nicotine) association p(FPLX:ERK) |
| pmid:19293145 | act(a(CHEBI:nicotine)) association a(MESH:Calcineurin) |
| pmid:19293145 | a(CHEBI:nicotine) increases a(CHEBI:"calcium(2+)") |
| pmid:19293145 | a(CHEBI:nicotine) increases sec(a(HBP:"sAPP-beta")) |
| pmid:19293145 | a(CHEBI:nicotine) decreases a(HBP:"sAPP-gamma") |
| pmid:17009926 | a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) |
| pmid:17009926 | a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) |
| pmid:28445721 | a(CHEBI:nicotine) regulates p(FPLX:CHRN) |
| pmid:21482353 | a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) |
| pmid:21482353 | a(CHEBI:nicotine) increases p(FPLX:CHRN) |
| pmid:21482353 | a(CHEBI:nicotine) increases p(FPLX:CHRN) |
| pmid:21482353 | a(CHEBI:nicotine) causesNoChange p(FPLX:CHRN) |
| pmid:21787755 | a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) |
| pmid:17009926 | a(CHEBI:nicotine) increases bp(GO:memory) |
| pmid:25514383 | a(CHEBI:nicotine) increases bp(GO:memory) |
| pmid:11230871 | a(CHEBI:nicotine) increases bp(GO:memory) |
| pmid:11230871 | a(CHEBI:nicotine) increases bp(GO:memory) |
| pmid:17009926 | a(CHEBI:nicotine) increases bp(GO:"circadian sleep/wake cycle, wakefulness") |
| pmid:26813123 | a(CHEBI:nicotine) increases act(a(MESH:"Receptors, Nicotinic")) |
| pmid:25514383 | a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:25514383 | a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:25514383 | a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:25514383 | a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:25514383 | a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta") |
| pmid:25514383 | a(CHEBI:nicotine) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:25514383 | a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:25514383 | a(CHEBI:nicotine) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:21482353 | a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:21482353 | a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:25514383 | a(CHEBI:nicotine) increases path(MESH:"Memory, Episodic") |
| pmid:25514383 | a(CHEBI:nicotine) increases path(MESH:"Spatial Memory") |
| pmid:25514383 | a(CHEBI:nicotine) decreases a(HBP:"amyloid-beta oligomers") |
| pmid:25514383 | a(CHEBI:nicotine) increases a(HBP:"Tau aggregates") |
| pmid:25514383 | a(CHEBI:nicotine) increases a(HBP:"Tau aggregates") |
| pmid:25514383 | a(CHEBI:nicotine) increases bp(GO:"p38MAPK cascade") |
| pmid:25514383 | a(CHEBI:nicotine) decreases path(MESH:"Plaque, Amyloid") |
| pmid:19721446 | a(CHEBI:nicotine) decreases path(MESH:"Plaque, Amyloid") |
| pmid:25514383 | a(CHEBI:nicotine) increases bp(GO:"long-term synaptic potentiation") |
| pmid:21482353 | a(CHEBI:nicotine) increases bp(GO:"long-term synaptic potentiation") |
| pmid:28445721 | a(CHEBI:nicotine) increases surf(p(HBP:HBP00174)) |
| pmid:28445721 | a(CHEBI:nicotine) increases a(HBP:HBP00174) |
| pmid:21482353 | a(CHEBI:nicotine) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNA4), p(HGNC:CHRNB2), p(HGNC:CHRNB2), p(HGNC:CHRNB2)) |
| pmid:21482353 | a(CHEBI:nicotine) increases act(p(MGI:Lynx1)) |
| pmid:21482353 | a(CHEBI:nicotine) increases bp(GO:cognition) |
| pmid:19721446 | a(CHEBI:nicotine) increases bp(GO:cognition) |
| pmid:21482353 | a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:21482353 | a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:21482353 | a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:21482353 | a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:21482353 | a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:18174175 | a(CHEBI:nicotine) increases a(HBP:"alpha-4 beta-2 nAChR") |
| pmid:21482353 | a(CHEBI:nicotine) causesNoChange a(HBP:"alpha-4-containing nAChR") |
| pmid:21482353 | a(CHEBI:nicotine) increases act(a(HBP:"alpha-4-containing nAChR")) |
| pmid:21482353 | a(CHEBI:nicotine) increases act(a(HBP:"alpha-4-containing nAChR")) |
| pmid:21482353 | a(CHEBI:nicotine) increases tloc(a(HBP:"alpha-4-containing nAChR"), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:"extracellular region")) |
| pmid:21482353 | a(CHEBI:nicotine) decreases act(a(MESH:"Dopaminergic Neurons")) |
| pmid:21482353 | a(CHEBI:nicotine) increases act(a(MESH:"GABAergic Neurons")) |
| pmid:21482353 | a(CHEBI:nicotine) decreases path(HBP:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") |
| pmid:11230871 | a(CHEBI:nicotine) increases bp(GO:learning) |
| pmid:11230871 | a(CHEBI:nicotine) increases path(MESH:Attention) |
| pmid:19721446 | a(CHEBI:nicotine) increases bp(MESH:"Sensory Gating") |
| pmid:19721446 | act(a(CHEBI:nicotine)) association p(HGNC:CHRNB4) |
| pmid:19721446 | act(a(CHEBI:nicotine)) association p(HGNC:CHRNA2) |
| pmid:19721446 | act(a(CHEBI:nicotine)) association p(HGNC:CHRNA5) |
| pmid:19721446 | act(a(CHEBI:nicotine)) decreases path(MESH:Nociception) |
| pmid:22040696 | a(CHEBI:nicotine) increases act(a(MESH:"SNARE Proteins")) |
| pmid:18174175 | a(CHEBI:nicotine) increases a(MESH:"alpha6beta2 nicotinic acetylcholine receptor") |
| pmid:23178521 | a(CHEBI:nicotine) decreases act(p(FPLX:NFkappaB)) |
| pmid:19126755 | a(MESH:"Electric Fish") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | a(HBP:"alpha-Bungarotoxin") decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(HBP:"alpha-Bungarotoxin") increases complex(a(HBP:"alpha-Bungarotoxin"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(HBP:"alpha-Bungarotoxin") decreases a(CHEBI:dopamine, loc(GO:"extracellular region")) |
| pmid:21482353 | a(HBP:"alpha-Bungarotoxin") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:19126755 | bp(GO:signaling) association a(CHEBI:acetylcholine) |
| pmid:19126755 | act(p(HGNC:CHAT)) directlyIncreases rxn(reactants(a(CHEBI:"acetyl-CoA"), a(CHEBI:choline)), products(a(CHEBI:acetylcholine))) |
| pmid:26813123 | p(HGNC:CHAT) increases rxn(reactants(a(CHEBI:"acetyl-CoA"), a(CHEBI:choline)), products(a(CHEBI:acetylcholine))) |
| pmid:19293145 | p(HGNC:CHAT) negativeCorrelation g(HGNC:APOE) |
| pmid:26813123 | act(p(HGNC:CHAT)) negativeCorrelation path(MESH:"Huntington Disease") |
| pmid:26813123 | act(p(HGNC:CHAT)) decreases path(MESH:Dementia) |
| pmid:16273023 | act(p(HGNC:CHAT), ma(cat)) increases a(CHEBI:acetylcholine) |
| pmid:24590577 | p(HGNC:CHAT) decreases a(CHEBI:acetylcholine) |
| pmid:25514383 | act(p(HGNC:CHAT)) increases a(CHEBI:acetylcholine) |
| pmid:18986241 | act(p(HGNC:CHAT)) directlyIncreases a(CHEBI:acetylcholine) |
| pmid:19721446 | p(HGNC:CHAT) increases a(CHEBI:acetylcholine) |
| pmid:18986241 | act(p(HGNC:CHAT)) decreases bp(HBP:Neurodegeneration) |
| pmid:28002468 | a(CHEBI:"acetyl-CoA") increases a(HBP:"cystein-dependent auto-acetylation") |
| pmid:17009926 | a(CHEBI:choline) increases act(p(FPLX:CHRN)) |
| pmid:26813123 | a(CHEBI:choline) increases a(CHEBI:acetylcholine) |
| pmid:26088141 | act(a(CHEBI:choline)) increases a(CHEBI:"calcium(2+)") |
| pmid:26088141 | act(a(CHEBI:choline)) association act(a(MESH:"Calcium Channels")) |
| pmid:26088141 | a(CHEBI:choline) association bp(MESH:"Pleckstrin Homology Domains") |
| pmid:26088141 | a(CHEBI:choline) increases bp(MESH:"Pleckstrin Homology Domains") |
| pmid:26088141 | a(CHEBI:choline) decreases complex(p(FPLX:"G_protein"), p(HGNC:CHRNA7)) |
| pmid:26088141 | a(CHEBI:choline) decreases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ)) |
| pmid:26088141 | a(CHEBI:choline) decreases complex(p(HGNC:CHRNA7), p(HGNCGENEFAMILY:"G protein subunits beta")) |
| pmid:21482353 | a(CHEBI:choline) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:21482353 | a(CHEBI:choline) increases act(a(HBP:"alpha-7-containing nAChR")) |
| pmid:19721446 | a(CHEBI:choline) increases bp(MESH:Neuroprotection) |
| pmid:19721446 | a(CHEBI:choline) decreases act(a(MESH:"alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid")) |
| pmid:26813123 | p(HGNC:CHRNA1) increases a(MESH:"Receptors, Nicotinic") |
| pmid:26813123 | p(HGNC:CHRNB1) increases a(MESH:"Receptors, Nicotinic") |
| pmid:26813123 | p(HGNC:CHRND) increases a(MESH:"Receptors, Nicotinic") |
| pmid:26813123 | p(HGNC:CHRNE) increases a(MESH:"Receptors, Nicotinic") |
| pmid:26813123 | p(HGNC:CHRNA2) increases a(MESH:"Receptors, Nicotinic") |
| pmid:19721446 | p(HGNC:CHRNA2) association act(a(CHEBI:nicotine)) |
| pmid:26813123 | p(HGNC:CHRNA3) increases a(MESH:"Receptors, Nicotinic") |
| pmid:11230871 | p(HGNC:CHRNA3) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:11230871 | p(HGNC:CHRNA3) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19721446 | p(HGNC:CHRNA3) association path(MESH:Craving) |
| pmid:19721446 | p(HGNC:CHRNA3) association path(MESH:Recurrence) |
| pmid:19126755 | p(HGNC:CHRNA4) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:11230871 | p(HGNC:CHRNA4) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19126755 | p(HGNC:CHRNA4) association p(HGNC:PTGS2) |
| pmid:19293145 | p(HGNC:CHRNA4) positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:17009926 | p(HGNC:CHRNA4) positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:19293145 | act(p(HGNC:CHRNA4)) decreases act(a(CHEBI:"L-glutamate(2-)")) |
| pmid:19293145 | act(p(HGNC:CHRNA4)) increases act(a(CHEBI:nicotine)) |
| pmid:19721446 | p(HGNC:CHRNA4) increases act(a(CHEBI:nicotine)) |
| pmid:19293145 | p(HGNC:CHRNA4) association bp(GO:"lipid metabolic process") |
| pmid:23038257 | p(HGNC:CHRNA4) association p(MESH:"Cytoskeletal Proteins") |
| pmid:23038257 | p(HGNC:CHRNA4) association bp(GO:"intracellular receptor signaling pathway") |
| pmid:17009926 | p(HGNC:CHRNA4) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:26813123 | p(HGNC:CHRNA4) increases a(MESH:"Receptors, Nicotinic") |
| pmid:11230871 | p(HGNC:CHRNA4) decreases complex(a(CHEBI:cytisine), p(FPLX:CHRN)) |
| pmid:19126755 | p(HGNC:CHRNA5) decreases path(MESH:"Inflammatory Bowel Diseases") |
| pmid:26813123 | p(HGNC:CHRNA5) increases a(MESH:"Receptors, Nicotinic") |
| pmid:19721446 | p(HGNC:CHRNA5) association act(a(CHEBI:nicotine)) |
| pmid:26813123 | p(HGNC:CHRNA6) increases a(MESH:"Receptors, Nicotinic") |
| pmid:21787755 | p(HGNC:CHRNA6) association path(MESH:Reward) |
| pmid:21787755 | p(HGNC:CHRNA6) association bp(MESH:"Drug Interactions") |
| pmid:21787755 | p(HGNC:CHRNA6) association sec(a(CHEBI:dopamine)) |
| pmid:19126755 | p(HGNC:CHRNA7) association a(MESH:Neurons) |
| pmid:19126755 | p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA5), p(HGNC:CHRNA7)) |
| pmid:19126755 | p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) |
| pmid:19126755 | p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA7), p(HGNC:CHRNB3)) |
| pmid:19126755 | act(p(HGNC:CHRNA7)) increases bp(GO:"action potential initiation") |
| pmid:19126755 | act(p(HGNC:CHRNA7, loc(GO:"axon terminus"))) regulates bp(GO:"synaptic transmission, glycinergic") |
| pmid:19126755 | act(p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) |
| pmid:19126755 | act(p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) |
| pmid:19293145 | act(p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") |
| pmid:22040696 | p(HGNC:CHRNA7) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Cytoplasm)) |
| pmid:19126755 | act(p(HGNC:CHRNA7)) increases bp(GO:"neuronal action potential") |
| pmid:19126755 | act(p(HGNC:CHRNA7, loc(GO:"glutamatergic synapse"))) regulates bp(GO:"synaptic transmission, dopaminergic") |
| pmid:19126755 | act(p(HGNC:CHRNA7, loc(GO:"glutamatergic synapse"))) increases a(CHEBI:"glutamate(2-)", loc(MESH:"Dopaminergic Neurons")) |
| pmid:19126755 | p(HGNC:CHRNA7, loc(MESH:"Mossy Fibers, Hippocampal")) regulates a(CHEBI:"glutamate(2-)", loc(MESH:"Pyramidal Cells")) |
| pmid:19293145 | act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:"glutamate(2-)")) |
| pmid:17009926 | act(p(HGNC:CHRNA7)) increases sec(a(CHEBI:"glutamate(2-)")) |
| pmid:19126755 | p(HGNC:CHRNA7) positiveCorrelation bp(GO:cognition) |
| pmid:19126755 | act(p(HGNC:CHRNA7)) association bp(GO:cognition) |
| pmid:19721446 | p(HGNC:CHRNA7) positiveCorrelation bp(GO:cognition) |
| pmid:19721446 | act(p(HGNC:CHRNA7)) increases bp(GO:cognition) |
| pmid:19126755 | p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | p(HGNC:CHRNA7) association path(MESH:"Alzheimer Disease") |
| pmid:11230871 | p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22040696 | p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19126755 | act(p(HGNC:CHRNA7)) increases sec(a(CHEBI:"gamma-aminobutyric acid")) |
| pmid:19126755 | act(p(HGNC:CHRNA7)) regulates a(CHEBI:dopamine, loc(GO:"extracellular region")) |
| pmid:19126755 | act(p(HGNC:CHRNA7)) increases a(CHEBI:dopamine, loc(GO:"extracellular region")) |
| pmid:19126755 | act(p(HGNC:CHRNA7)) association path(MESH:"Sensory Gating") |
| pmid:19126755 | act(p(HGNC:CHRNA7)) increases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) |
| pmid:19293145 | p(HGNC:CHRNA7) positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:19293145 | p(HGNC:CHRNA7) decreases act(a(CHEBI:"amyloid-beta")) |
| pmid:19293145 | p(HGNC:CHRNA7) increases a(CHEBI:"amyloid-beta") |
| pmid:19293145 | p(HGNC:CHRNA7) association a(CHEBI:"amyloid-beta") |
| pmid:17009926 | p(HGNC:CHRNA7) positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:19126755 | act(p(HGNC:CHRNA7)) increases a(CHEBI:anandamide) |
| pmid:19126755 | p(HGNC:CHRNA7) regulates bp(GO:"cell cycle") |
| pmid:19126755 | act(p(HGNC:CHRNA7)) association a(CHEBI:nicotine) |
| pmid:19126755 | p(HGNC:CHRNA7) regulates a(CHEBI:nicotine) |
| pmid:19293145 | p(HGNC:CHRNA7) regulates act(a(CHEBI:nicotine)) |
| pmid:19293145 | p(HGNC:CHRNA7) increases a(CHEBI:nicotine) |
| pmid:19126755 | p(HGNC:CHRNA7) regulates path(MESH:"Substance Withdrawal Syndrome") |
| pmid:19293145 | p(HGNC:CHRNA7) association path(MESH:"Plaque, Amyloid") |
| pmid:19293145 | p(HGNC:CHRNA7) increases act(a(CHEBI:galanthamine)) |
| pmid:19293145 | act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:ethanol)) |
| pmid:19293145 | act(p(HGNC:CHRNA7)) decreases bp(GO:"cell death") |
| pmid:19293145 | act(p(HGNC:CHRNA7)) increases a(CHEBI:glucose) |
| pmid:19293145 | act(p(HGNC:CHRNA7)) increases a(MESH:Oxygen) |
| pmid:19293145 | act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:"L-glutamate(2-)")) |
| pmid:19293145 | act(p(HGNC:CHRNA7)) causesNoChange act(a(CHEBI:"N-methyl-4-phenylpyridinium")) |
| pmid:19293145 | act(p(HGNC:CHRNA7)) decreases act(p(HGNC:FAS)) |
| pmid:19293145 | act(p(HGNC:CHRNA7)) increases act(p(HGNC:JAK2)) |
| pmid:19293145 | p(HGNC:CHRNA7) increases bp(GO:"MAPK cascade") |
| pmid:19293145 | p(HGNC:CHRNA7) increases bp(GO:"MAPK cascade") |
| pmid:19293145 | act(p(HGNC:CHRNA7)) increases bp(GO:"calcium ion transport") |
| pmid:19293145 | act(p(HGNC:CHRNA7)) association bp(GO:"calcium-mediated signaling") |
| pmid:19293145 | p(HGNC:CHRNA7) increases act(p(HGNCGENEFAMILY:"Ryanodine receptors")) |
| pmid:17009926 | p(HGNC:CHRNA7) increases bp(GO:"neurotransmitter secretion") |
| pmid:22040696 | p(HGNC:CHRNA7) increases bp(GO:"neurotransmitter secretion") |
| pmid:17009926 | p(HGNC:CHRNA7) increases act(complex(GO:"voltage-gated calcium channel complex")) |
| pmid:17009926 | act(p(HGNC:CHRNA7)) increases bp(GO:"synaptic transmission, glutamatergic") |
| pmid:17009926 | p(HGNC:CHRNA7) association a(HBP:"amyloid-beta aggregates") |
| pmid:17009926 | p(HGNC:CHRNA7) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:26813123 | p(HGNC:CHRNA7) increases a(MESH:"Receptors, Nicotinic") |
| pmid:26088141 | p(HGNC:CHRNA7) increases bp(HBP:"nAChR assembly") |
| pmid:26088141 | p(HGNC:CHRNA7) increases p(HGNC:CHRNA7) |
| pmid:26088141 | p(HGNC:CHRNA7) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ)) |
| pmid:26088141 | p(HGNC:CHRNA7) increases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7)) |
| pmid:18986241 | p(HGNC:CHRNA7) increases complex(p(HGNC:APP), p(HGNC:CHRNA7)) |
| pmid:18986241 | p(HGNC:CHRNA7) increases complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) |
| pmid:19721446 | p(HGNC:CHRNA7) association a(MESH:Hippocampus) |
| pmid:19721446 | p(HGNC:CHRNA7) association bp(GO:memory) |
| pmid:19721446 | act(p(HGNC:CHRNA7)) decreases bp(GO:memory) |
| pmid:19721446 | p(HGNC:CHRNA7) association bp(GO:learning) |
| pmid:19721446 | p(HGNC:CHRNA7) association bp(MESH:Neuroprotection) |
| pmid:19721446 | act(p(HGNC:CHRNA7)) decreases bp(MESH:Neuroprotection) |
| pmid:19721446 | p(HGNC:CHRNA7) association bp(MESH:"Sensory Gating") |
| pmid:19721446 | p(HGNC:CHRNA7) association a(CHEBI:clozapine) |
| pmid:22040696 | p(HGNC:CHRNA7) regulates bp(GO:"chemical synaptic transmission") |
| pmid:22040696 | p(HGNC:CHRNA7) regulates bp(GO:"neuron-neuron synaptic transmission") |
| pmid:22040696 | p(HGNC:CHRNA7) association path(MESH:"Neurodegenerative Diseases") |
| pmid:22040696 | p(HGNC:CHRNA7) association p(HGNC:BDNF) |
| pmid:22040696 | tloc(p(HGNC:CHRNA7), fromLoc(GO:"cell surface"), toLoc(GO:endosome)) increases act(p(HGNC:CREB1), ma(tscript)) |
| pmid:22040696 | p(HGNC:CHRNA7) negativeCorrelation path(MESH:Schizophrenia) |
| pmid:22040696 | p(HGNC:CHRNA7) decreases path(MESH:"Renal Insufficiency") |
| pmid:22040696 | p(HGNC:CHRNA7) decreases bp(GO:"cytokine production") |
| pmid:22040696 | p(HGNC:CHRNA7) decreases bp(GO:"apoptotic process") |
| pmid:28901280 | p(HGNC:CHRNA7) regulates bp(MESH:"Cell Survival") |
| pmid:28901280 | p(HGNC:CHRNA7) regulates path(MESH:Inflammation) |
| pmid:28901280 | p(HGNC:CHRNA7) association path(MESH:Neoplasms) |
| pmid:28901280 | p(HGNC:CHRNA7) increases bp(GO:"intracellular receptor signaling pathway") |
| pmid:28901280 | p(HGNC:CHRNA7) increases bp(GO:"JAK-STAT cascade") |
| pmid:26813123 | p(HGNC:CHRNA9) increases a(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | p(HGNC:CHRNA9) increases path(MESH:Neoplasms) |
| pmid:26813123 | p(HGNC:CHRNA10) increases a(MESH:"Receptors, Nicotinic") |
| pmid:17009926 | act(p(HGNC:CHRNB2)) increases bp(GO:"depolarization of postsynaptic membrane") |
| pmid:26813123 | p(HGNC:CHRNB2) increases a(MESH:"Receptors, Nicotinic") |
| pmid:19721446 | p(HGNC:CHRNB2) association p(HGNCGENEFAMILY:Tubulins) |
| pmid:19721446 | p(HGNC:CHRNB2) association p(HGNC:DNM1) |
| pmid:19721446 | p(HGNC:CHRNB2) association p(HGNCGENEFAMILY:"Clathrin subunits") |
| pmid:19721446 | p(HGNC:CHRNB2) increases act(a(CHEBI:nicotine)) |
| pmid:26813123 | p(HGNC:CHRNB3) increases a(MESH:"Receptors, Nicotinic") |
| pmid:19126755 | p(HGNC:CHRNB4) association path(MESH:"Drug Tolerance") |
| pmid:26813123 | p(HGNC:CHRNB4) increases a(MESH:"Receptors, Nicotinic") |
| pmid:19721446 | p(HGNC:CHRNB4) association act(a(CHEBI:nicotine)) |
| pmid:19721446 | p(HGNC:CHRNB4) association path(MESH:Craving) |
| pmid:19721446 | p(HGNC:CHRNB4) association path(MESH:Recurrence) |
| pmid:19126755 | p(HGNC:TNF) increases bp(GO:"MAPK cascade") |
| pmid:19293145 | p(HGNC:TNF) increases act(a(CHEBI:nicotine)) |
| pmid:19293145 | p(HGNC:TNF) decreases act(a(CHEBI:"N-methyl-D-aspartic acid")) |
| pmid:23178521 | p(HGNC:TNF) increases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | p(HGNC:TNF) increases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | p(HGNC:TNF) increases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | p(HGNC:TNF) causesNoChange p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | p(HGNC:TNF) increases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | p(HGNC:TNF) increases p(HGNC:STAT3, pmod(Ph)) |
| pmid:19126755 | p(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:Aging) |
| pmid:19126755 | p(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19126755 | p(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19126755 | p(HBP:"alpha-4 beta-2 nAChR") increases complex(a(CHEBI:nicotine), p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19126755 | act(p(HBP:"alpha-4 beta-2 nAChR")) decreases bp(GO:"synaptic transmission, GABAergic") |
| pmid:19126755 | act(p(HBP:"alpha-4 beta-2 nAChR")) decreases act(complex(GO:"voltage-gated calcium channel complex")) |
| pmid:19126755 | act(p(HBP:"alpha-4 beta-2 nAChR", loc(MESH:"GABAergic Neurons"))) increases act(a(MESH:"Dopaminergic Neurons")) |
| pmid:19126755 | p(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation bp(GO:cognition) |
| pmid:26472524 | act(p(HBP:"alpha-4 beta-2 nAChR")) increases bp(GO:"depolarization of postsynaptic membrane") |
| pmid:19126755 | p(HBP:"alpha-6 alpha-4 beta-2 beta-3 nAChR", loc(MESH:"Basal Ganglia")) association path(MESH:"Parkinson Disease") |
| pmid:19126755 | p(HBP:"alpha-7-containing nAChR") increases bp(GO:"calcium ion transport into cytosol") |
| pmid:26472524 | p(HBP:"alpha-7-containing nAChR") increases act(p(HGNC:CHRNA7)) |
| pmid:19126755 | a(MESH:Manduca) association bp(GO:"establishment of blood-brain barrier") |
| pmid:19126755 | bp(GO:"establishment of blood-brain barrier") association a(MESH:Manduca) |
| pmid:19126755 | a(MESH:Neurons) increases deg(a(CHEBI:nicotine)) |
| pmid:19126755 | a(MESH:Neurons) decreases r(HGNC:CHRNA3) |
| pmid:19126755 | a(MESH:Neurons) increases r(HGNC:CHRNA4) |
| pmid:19126755 | a(MESH:Neurons) association p(HGNC:CHRNA7) |
| pmid:19126755 | a(MESH:Neurons) regulates a(CHEBI:"kynurenic acid") |
| pmid:21482353 | a(MESH:Neurons) negativeCorrelation act(p(FPLX:CHRN)) |
| pmid:21482353 | a(MESH:Neurons) increases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:28901280 | a(MESH:Neurons) association p(MESH:"Receptors, Nicotinic") |
| pmid:27671637 | act(a(MESH:Neurons)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:29238289 | act(a(MESH:Neurons)) increases p(HGNC:MAPT) |
| pmid:29238289 | act(a(MESH:Neurons)) increases p(HGNC:MAPT) |
| pmid:29238289 | a(MESH:Neurons) causesNoChange p(HGNC:MAPT) |
| pmid:27796283 | act(a(MESH:Neurons)) increases p(HGNC:CAMKV) |
| pmid:27087442 | act(a(MESH:Neurons)) positiveCorrelation p(MGI:Cdk5r1) |
| pmid:27087442 | act(a(MESH:Neurons)) positiveCorrelation act(p(HBP:RAC1b)) |
| pmid:27087442 | act(a(MESH:Neurons)) negativeCorrelation p(MGI:Cdk5) |
| pmid:19126755 | path(HBP:neurotoxicity) association a(CHEBI:nicotine) |
| pmid:19293145 | path(HBP:neurotoxicity) association a(HBP:"amyloid-beta oligomers") |
| pmid:19293145 | path(HBP:neurotoxicity) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:24027553 | path(HBP:neurotoxicity) positiveCorrelation a(HBP:"Tau aggregates") |
| pmid:19126755 | complex(a(MESH:"alpha-cobratoxin"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | complex(a(HBP:"kappa-Bungarotoxin"), p(HBP:"alpha-3 beta-4 nAChR")) decreases act(p(HBP:"alpha-3 beta-4 nAChR")) |
| pmid:21787755 | a(HBP:"kappa-Bungarotoxin") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) |
| pmid:21787755 | a(HBP:"kappa-Bungarotoxin") decreases act(a(HBP:"alpha-6-containing nAChR")) |
| pmid:19126755 | act(p(HBP:"alpha-3 beta-4 nAChR")) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) |
| pmid:19126755 | complex(a(HBP:"kappa-Bungarotoxin"), p(HGNC:CHRNB4)) decreases act(p(HGNC:CHRNB4)) |
| pmid:19126755 | a(MESH:Conotoxins) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(MESH:Conotoxins) decreases act(p(HGNCGENEFAMILY:"Potassium voltage-gated channels")) |
| pmid:19126755 | a(MESH:Conotoxins) decreases act(a(MESH:"Voltage-Gated Sodium Channels")) |
| pmid:19721446 | a(MESH:Conotoxins) association complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) |
| pmid:19721446 | a(MESH:Conotoxins) decreases act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) |
| pmid:19721446 | a(MESH:Conotoxins) decreases path(MESH:Pain) |
| pmid:19126755 | p(HGNCGENEFAMILY:"Potassium voltage-gated channels") association a(CHEBI:anandamide) |
| pmid:19126755 | a(TAXONOMY:1163) increases a(CHEBI:"Anatoxin a") |
| pmid:19126755 | complex(a(CHEBI:"Anatoxin a"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(TAXONOMY:92736) increases a(CHEBI:epibatidine) |
| pmid:19293145 | a(CHEBI:epibatidine) causesNoChange bp(GO:memory) |
| pmid:19293145 | a(CHEBI:epibatidine) causesNoChange bp(GO:cognition) |
| pmid:19293145 | a(CHEBI:epibatidine) causesNoChange path(MESH:"Plaque, Amyloid") |
| pmid:19293145 | a(CHEBI:epibatidine) causesNoChange bp(MESH:"Neurofibrillary Tangles") |
| pmid:28132910 | a(CHEBI:epibatidine) decreases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384)) |
| pmid:19126755 | complex(a(CHEBI:epibatidine), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | complex(a(CHEBI:epibatidine), p(HBP:"alpha-4 beta-2 nAChR")) increases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19126755 | complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7, loc(MESH:Muscles))) |
| pmid:19293145 | a(MESH:methyllycaconitine) decreases act(p(HGNC:CHRNA7)) |
| pmid:19293145 | a(MESH:methyllycaconitine) decreases act(p(HGNC:CHRNA7)) |
| pmid:19293145 | a(MESH:methyllycaconitine) increases bp(MESH:Neuroprotection) |
| pmid:19293145 | a(MESH:methyllycaconitine) decreases path(HBP:neurotoxicity) |
| pmid:25881725 | a(MESH:methyllycaconitine) decreases act(a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")) |
| pmid:25881725 | a(MESH:methyllycaconitine) decreases act(a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")) |
| pmid:25881725 | a(MESH:methyllycaconitine) decreases act(a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")) |
| pmid:25881725 | a(MESH:methyllycaconitine) decreases act(a(CHEBI:galanthamine)) |
| pmid:25881725 | a(MESH:methyllycaconitine) decreases act(a(CHEBI:galanthamine)) |
| pmid:25881725 | a(MESH:methyllycaconitine) decreases act(a(CHEBI:galanthamine)) |
| pmid:25881725 | a(MESH:methyllycaconitine) decreases act(p(MGI:Chrna7)) |
| pmid:25881725 | a(MESH:methyllycaconitine) decreases act(p(MGI:Chrna7)) |
| pmid:25881725 | a(MESH:methyllycaconitine) decreases p(MGI:Chrna7) |
| pmid:25881725 | a(MESH:methyllycaconitine) decreases path(MESH:"Spatial Memory") |
| pmid:25881725 | a(MESH:methyllycaconitine) causesNoChange r(MGI:Chrna7) |
| pmid:19721446 | a(MESH:methyllycaconitine) decreases act(a(DRUGBANK:Facinicline)) |
| pmid:19126755 | complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA6)) decreases act(p(HGNC:CHRNA6, loc(MESH:Muscles))) |
| pmid:19126755 | complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA3)) decreases act(p(HGNC:CHRNA3, loc(MESH:Muscles))) |
| pmid:19126755 | r(HGNC:CHRNA3) association p(HGNCGENEFAMILY:"ETS transcription factor family") |
| pmid:19126755 | r(HGNC:CHRNB4) association p(HGNCGENEFAMILY:"ETS transcription factor family") |
| pmid:21787755 | r(HGNC:CHRNB4) association r(HGNC:CHRNA4) |
| pmid:21787755 | r(HGNC:CHRNA4) association r(HGNC:CHRNB4) |
| pmid:21787755 | r(HGNC:CHRNA6) association path(MESH:Reward) |
| pmid:21787755 | r(HGNC:CHRNA6) association bp(MESH:"Drug Interactions") |
| pmid:21787755 | r(HGNC:CHRNA6) association sec(a(CHEBI:dopamine)) |
| pmid:19126755 | a(MESH:Fetus) increases r(HGNC:CHRNA3, loc(MESH:Brain)) |
| pmid:19126755 | path(MESH:"Trauma, Nervous System") increases r(HGNC:CHRNA3, loc(MESH:Brain)) |
| pmid:24561250 | path(MESH:"Trauma, Nervous System") increases path(MESH:"Alzheimer Disease") |
| pmid:24561250 | path(MESH:"Trauma, Nervous System") increases complex(GO:"inflammasome complex") |
| pmid:19126755 | a(MESH:Adult) decreases r(HGNC:CHRNA3) |
| pmid:19126755 | a(MESH:Adult) increases r(HGNC:CHRNA4) |
| pmid:19126755 | bp(GO:"phosphatidylinositol 3-kinase signaling") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:22040696 | bp(GO:"phosphatidylinositol 3-kinase signaling") decreases bp(GO:"neuron death") |
| pmid:22040696 | bp(GO:"phosphatidylinositol 3-kinase signaling") increases p(FPLX:CHRN) |
| pmid:19126755 | r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases bp(HBP:"nAChR assembly") |
| pmid:19126755 | act(p(HGNC:NGF)) increases bp(GO:"MAPK cascade") |
| pmid:19126755 | act(p(HGNC:NGF)) increases complex(p(HGNC:JUN), p(HGNC:SP1)) |
| pmid:19126755 | p(HGNC:NGF) regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:18986241 | p(HGNC:NGF) isA a(MESH:D009414) |
| pmid:18986241 | act(p(HGNC:NGF)) increases bp(GO:"GO:0000165") |
| pmid:18986241 | p(HGNC:NGF) causesNoChange path(MESH:D003929) |
| pmid:18986241 | p(HGNC:NGF) causesNoChange path(MESH:D016263) |
| pmid:18986241 | p(HGNC:NGF) causesNoChange path(MESH:D000544) |
| pmid:18986241 | p(HGNC:NGF) association bp(GO:"GO:0060384") |
| pmid:18986241 | p(HGNC:NGF) association bp(GO:"GO:0007269") |
| pmid:18986241 | p(HGNC:NGF) association bp(GO:"GO:0048485") |
| pmid:18986241 | p(HGNC:NGF) association path(MESH:D002100) |
| pmid:18986241 | p(HGNC:NGF) association path(MESH:D006930) |
| pmid:18986241 | p(HGNC:NGF) decreases path(MESH:D060825) |
| pmid:24686445 | p(HGNC:NGF) increases p(FPLX:ERK, pmod(Ph)) |
| pmid:24686445 | p(HGNC:NGF) increases act(p(HGNC:KAT2B)) |
| pmid:19126755 | act(complex(p(HGNC:JUN), p(HGNC:SP1)), ma(tscript)) increases r(HGNC:CHRNB4) |
| pmid:18494933 | p(HGNC:JUN) partOf p(FPLX:AP1) |
| pmid:19126755 | act(p(HGNC:SOX10)) increases r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | composite(p(HGNC:CHRNA7), p(HGNC:NGF)) increases r(HGNC:CHRNB4) |
| pmid:19126755 | p(HGNCGENEFAMILY:"ETS transcription factor family") association r(HGNC:CHRNA3) |
| pmid:19126755 | p(HGNCGENEFAMILY:"ETS transcription factor family") association r(HGNC:CHRNB4) |
| pmid:19126755 | complex(p(HGNC:CHRNA5), p(HGNC:CHRNA7)) association p(HGNC:CHRNA7) |
| pmid:19126755 | complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) association p(HGNC:CHRNA7) |
| pmid:25514383 | complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) increases a(HBP:"alpha-7 beta-2 nAChR") |
| pmid:25514383 | complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) increases surf(a(HBP:"alpha-7 beta-2 nAChR")) |
| pmid:19126755 | complex(p(HGNC:CHRNA7), p(HGNC:CHRNB3)) association p(HGNC:CHRNA7) |
| pmid:19126755 | a(MESH:Muscles) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) |
| pmid:19126755 | a(MESH:Muscles) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE), loc(MESH:"Neuromuscular Junction")) |
| pmid:19126755 | a(MESH:Muscles) increases r(HGNC:CHRNA1) |
| pmid:19126755 | a(MESH:Muscles) increases r(HGNC:CHRNB1) |
| pmid:19126755 | a(MESH:Muscles) increases r(HGNC:CHRND) |
| pmid:19126755 | a(MESH:Muscles) increases r(HGNC:CHRNG) |
| pmid:19126755 | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) association a(MESH:Muscles) |
| pmid:19126755 | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"cell surface")) |
| pmid:23038257 | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) association a(CHEBI:chlorpromazine) |
| pmid:26813123 | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) increases p(FPLX:CHRN) |
| pmid:19126755 | act(p(HGNC:CHRNG)) increases bp(GO:"long-term synaptic potentiation") |
| pmid:26813123 | p(HGNC:CHRNG) increases a(MESH:"Receptors, Nicotinic") |
| pmid:19126755 | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE), loc(MESH:"Neuromuscular Junction")) association a(MESH:Muscles) |
| pmid:19126755 | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) decreases deg(complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))) |
| pmid:19126755 | bp(GO:"depolarization of postsynaptic membrane") increases r(HGNC:CHRNE) |
| pmid:19126755 | bp(GO:"depolarization of postsynaptic membrane") increases act(complex(GO:"voltage-gated calcium channel complex")) |
| pmid:17009926 | bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"regulation of action potential firing rate") |
| pmid:26472524 | bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"regulation of action potential firing rate") |
| pmid:17009926 | bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"long-term synaptic potentiation") |
| pmid:19126755 | r(HGNC:CHRNE) decreases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) |
| pmid:19126755 | r(HGNC:CHRNE) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) |
| pmid:19126755 | composite(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG)) |
| pmid:19126755 | complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) |
| pmid:19126755 | complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) |
| pmid:19126755 | composite(complex(p(HGNC:CHRNA1), p(HGNC:CHRND)), complex(p(HGNC:CHRNA1), p(HGNC:CHRNG)), p(HGNC:CHRNB1)) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) |
| pmid:19126755 | a(MESH:Oocytes) association composite(p(HGNC:CHRNA4), p(HGNC:CHRNA7), p(HGNC:CHRNB2)) |
| pmid:19126755 | composite(p(HGNC:CHRNA4), p(HGNC:CHRNA7), p(HGNC:CHRNB2)) association a(MESH:Oocytes) |
| pmid:19126755 | a(MESH:Hippocampus) increases p(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19126755 | a(MESH:Hippocampus) increases p(HGNC:CHRNA7) |
| pmid:19721446 | a(MESH:Hippocampus) association p(HGNC:CHRNA7) |
| pmid:24511233 | a(MESH:Hippocampus) association bp(GO:cognition) |
| pmid:24511233 | a(MESH:Hippocampus) association bp(GO:learning) |
| pmid:24511233 | a(MESH:Hippocampus) association bp(GO:learning) |
| pmid:24511233 | a(MESH:Hippocampus) association bp(GO:memory) |
| pmid:24511233 | a(MESH:Hippocampus) association bp(GO:memory) |
| pmid:19721446 | a(MESH:Hippocampus) association bp(GO:memory) |
| pmid:24511233 | a(MESH:Hippocampus) association p(HGNC:CHRM4) |
| pmid:24590577 | a(MESH:Hippocampus) association p(HGNC:CHRM1) |
| pmid:24590577 | a(MESH:Hippocampus) association p(HGNC:CHRM2) |
| pmid:24590577 | a(MESH:Hippocampus) association p(HGNC:CHRM3) |
| pmid:26390242 | a(MESH:Hippocampus) positiveCorrelation a(CHEBI:salsalate) |
| pmid:19126755 | a(MESH:Ganglia) increases p(HBP:"alpha-3 beta-2 nAChR") |
| pmid:19126755 | a(MESH:Ganglia) increases p(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19126755 | composite(a(MESH:"HEK293 Cells"), g(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7)) |
| pmid:19126755 | g(HGNC:CHRNA7) increases p(HGNC:CHRNA7) |
| pmid:19126755 | g(HGNC:CHRNA7) association path(MESH:"Sensory Gating") |
| pmid:19126755 | a(MESH:"Cell Line") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | a(MESH:"Cell Line") regulates complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| pmid:19126755 | composite(g(HGNC:CHRNA4), g(HGNC:CHRNB2)) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| pmid:25514383 | complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) increases a(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19721446 | complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) association a(MESH:"Dopaminergic Neurons") |
| pmid:19126755 | p(HGNC:CHRNA7, frag("23_46")) increases complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7)) |
| pmid:19126755 | a(MESH:"Endoplasmic Reticulum") regulates bp(HBP:"nAChR assembly") |
| pmid:19126755 | a(MESH:"Endoplasmic Reticulum") regulates p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | a(MESH:"Endoplasmic Reticulum") increases deg(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(GO:"endoplasmic reticulum"))) |
| pmid:19126755 | bp(HBP:"nAChR assembly") increases p(HBP:"alpha-3 beta-4 nAChR", loc(GO:"cell surface")) |
| pmid:19126755 | bp(HBP:"nAChR assembly") increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"cell surface")) |
| pmid:19126755 | a(CHEBI:"proteasome inhibitor") decreases deg(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(GO:"endoplasmic reticulum"))) |
| pmid:29626319 | a(CHEBI:"proteasome inhibitor") increases bp(GO:autophagy) |
| pmid:29626319 | a(CHEBI:"proteasome inhibitor") decreases p(HGNC:MAPT) |
| pmid:29626319 | a(CHEBI:"proteasome inhibitor") increases p(HGNC:BAG3) |
| pmid:21787755 | a(HBP:"alpha-3 beta-2 nAChR") regulates sec(a(CHEBI:"gamma-aminobutyric acid")) |
| pmid:19126755 | composite(a(CHEBI:nicotine), g(HGNC:CHRNA4), g(HGNC:CHRNA6), g(HGNC:CHRNB2), g(HGNC:CHRNB3)) increases composite(p(HGNC:CHRNA4), p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) |
| pmid:19126755 | act(a(HBP:"alpha-4 beta-2 nAChR")) decreases act(a(MESH:Interneurons)) |
| pmid:19293145 | a(HBP:"alpha-4 beta-2 nAChR") association path(MESH:"Alzheimer Disease") |
| pmid:25514383 | a(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation bp(GO:"calcium ion transport") |
| pmid:25514383 | act(a(HBP:"alpha-4 beta-2 nAChR")) decreases bp(GO:"cellular calcium ion homeostasis") |
| pmid:25514383 | act(a(HBP:"alpha-4 beta-2 nAChR")) increases path(HBP:"mitochondrial dysfunction") |
| pmid:25514383 | act(a(HBP:"alpha-4 beta-2 nAChR")) increases bp(GO:"response to oxidative stress") |
| pmid:21482353 | a(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation bp(GO:cognition) |
| pmid:21482353 | a(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"Dopaminergic Neurons") |
| pmid:21482353 | a(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"GABAergic Neurons") |
| pmid:19126755 | sec(a(CHEBI:"gamma-aminobutyric acid")) increases bp(GO:"hyperpolarization of postsynaptic membrane") |
| pmid:21482353 | a(CHEBI:"gamma-aminobutyric acid") increases act(p(HGNC:GABBR1)) |
| pmid:21482353 | a(CHEBI:"gamma-aminobutyric acid") increases act(p(HGNC:GABBR2)) |
| pmid:21482353 | a(CHEBI:"gamma-aminobutyric acid") decreases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:19126755 | bp(GO:"action potential initiation") decreases a(MESH:"Electric Stimulation", loc(GO:"Schaffer axon collateral")) |
| pmid:19126755 | bp(GO:"action potential initiation") increases act(a(MESH:"Perforant Pathway")) |
| pmid:26813123 | bp(GO:"action potential initiation") increases tloc(a(CHEBI:choline), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:26813123 | bp(GO:"action potential initiation") increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) |
| pmid:26813123 | bp(GO:"action potential initiation") increases a(CHEBI:acetylcholine) |
| pmid:26813123 | bp(GO:"action potential initiation") increases a(CHEBI:acetylcholine) |
| pmid:26813123 | bp(GO:"action potential initiation") association complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) |
| pmid:28901280 | bp(GO:"action potential initiation") association p(MESH:"Receptors, Nicotinic") |
| pmid:19126755 | act(p(FPLX:CREB), ma(tscript)) regulates bp(GO:"gene expression") |
| pmid:19126755 | act(p(FPLX:CREB)) association bp(MESH:"Neuronal Plasticity") |
| pmid:19126755 | act(p(FPLX:CREB)) association path(MESH:"Tobacco Use Disorder") |
| pmid:27550730 | act(p(FPLX:CREB)) negativeCorrelation act(p(HGNC:PDE5A)) |
| pmid:19126755 | act(complex(GO:"voltage-gated calcium channel complex")) increases bp(GO:"calcineurin-mediated signaling") |
| pmid:19126755 | act(complex(GO:"voltage-gated calcium channel complex")) decreases act(p(FPLX:CREB), ma(tscript)) |
| pmid:19126755 | complex(GO:"voltage-gated calcium channel complex") association a(CHEBI:anandamide) |
| pmid:14556719 | bp(GO:"synaptic transmission, dopaminergic") negativeCorrelation path(MESH:"Parkinson Disease") |
| pmid:19126755 | p(HBP:"alpha-4-containing nAChR") increases sec(a(CHEBI:dopamine)) |
| pmid:19126755 | p(HBP:"alpha-6-containing nAChR") increases sec(a(CHEBI:dopamine)) |
| pmid:19126755 | bp(GO:"neuronal action potential") increases sec(a(CHEBI:dopamine)) |
| pmid:28445721 | bp(GO:"neuronal action potential") regulates p(FPLX:CHRN) |
| pmid:19126755 | a(CHEBI:dopamine) decreases path(MESH:"Parkinson Disease") |
| pmid:21787755 | sec(a(CHEBI:dopamine)) association r(HGNC:CHRNA6) |
| pmid:21787755 | sec(a(CHEBI:dopamine)) association p(HGNC:CHRNA6) |
| pmid:27075649 | a(CHEBI:dopamine) increases a(HBP:HBP00093) |
| pmid:27075649 | a(CHEBI:dopamine) increases a(HBP:HBP00093) |
| pmid:19126755 | a(CHEBI:"glutamate(2-)", loc(MESH:"Dopaminergic Neurons")) increases bp(GO:"synaptic transmission, dopaminergic") |
| pmid:19293145 | act(a(CHEBI:"glutamate(2-)")) increases bp(HBP:Excitotoxicity) |
| pmid:17009926 | sec(a(CHEBI:"glutamate(2-)")) increases bp(GO:"long-term synaptic potentiation") |
| pmid:16273023 | a(CHEBI:"glutamate(2-)") directlyIncreases bp(GO:"GO:0014047") |
| pmid:16273023 | a(CHEBI:"glutamate(2-)") directlyIncreases act(p(MESH:D017470)) |
| pmid:21482353 | a(MESH:"Dopaminergic Neurons") positiveCorrelation a(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19721446 | a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) |
| pmid:19721446 | a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) |
| pmid:19721446 | a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2)) |
| pmid:19721446 | a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| pmid:19721446 | a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2)) |
| pmid:28901280 | a(MESH:"Dopaminergic Neurons") regulates a(MESH:Nicotine) |
| pmid:14556719 | a(MESH:"Dopaminergic Neurons") negativeCorrelation p(HGNC:PRKN) |
| pmid:19126755 | a(MESH:Neuroglia) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | a(MESH:Keratinocytes) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:28901280 | a(MESH:Keratinocytes) increases complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) |
| pmid:28901280 | a(MESH:Keratinocytes) increases p(HGNC:CHRNA9) |
| pmid:19126755 | a(MESH:"Endothelial Cells") increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:28901280 | a(MESH:"Endothelial Cells") increases a(MESH:Acetylcholine) |
| pmid:28901280 | a(MESH:"Endothelial Cells") increases a(MESH:"Choline O-Acetyltransferase") |
| pmid:24027553 | a(MESH:"Endothelial Cells") increases sec(a(CHEBI:Thrombin)) |
| pmid:19126755 | p(HGNC:ACHE) decreases act(a(CHEBI:nicotine)) |
| pmid:19293145 | p(HGNC:ACHE) decreases a(CHEBI:acetylcholine) |
| pmid:17009926 | act(p(HGNC:ACHE), ma(pep)) directlyIncreases deg(a(CHEBI:acetylcholine)) |
| pmid:26813123 | p(HGNC:ACHE) decreases act(a(CHEBI:acetylcholine)) |
| pmid:21482353 | p(HGNC:ACHE) increases deg(a(CHEBI:acetylcholine)) |
| pmid:23038257 | p(HGNC:ACHE) increases act(a(CHEBI:chlorpromazine)) |
| pmid:17009926 | act(p(HGNC:ACHE), ma(pep)) directlyIncreases rxn(reactants(a(CHEBI:acetylcholine)), products(a(CHEBI:acetate), a(CHEBI:choline))) |
| pmid:26813123 | p(HGNC:ACHE) increases rxn(reactants(a(CHEBI:acetylcholine)), products(a(CHEBI:acetate), a(CHEBI:choline))) |
| pmid:26813123 | p(HGNC:ACHE) association path(MESH:"Alzheimer Disease") |
| pmid:11230871 | act(p(HGNC:ACHE)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26813123 | p(HGNC:ACHE) increases a(CHEBI:"amyloid-beta") |
| pmid:25514383 | act(p(HGNC:ACHE)) increases bp(GO:"acetylcholine catabolic process") |
| pmid:21482353 | act(p(HGNC:ACHE)) decreases bp(GO:"synaptic transmission, cholinergic") |
| pmid:18986241 | p(HGNC:ACHE) association path(MESH:D058225) |
| pmid:18986241 | p(HGNC:ACHE) increases bp(GO:"GO:1990000") |
| pmid:19126755 | a(MESH:"Cholinesterase Inhibitors") causesNoChange act(p(HGNC:CHRNA7)) |
| pmid:19293145 | act(a(MESH:"Cholinesterase Inhibitors")) decreases act(a(CHEBI:"amyloid-beta")) |
| pmid:19293145 | act(a(MESH:"Cholinesterase Inhibitors")) decreases act(a(CHEBI:"L-glutamate(2-)")) |
| pmid:26813123 | a(MESH:"Cholinesterase Inhibitors") increases a(CHEBI:acetylcholine) |
| pmid:26813123 | a(MESH:"Cholinesterase Inhibitors") increases bp(GO:cognition) |
| pmid:19126755 | a(CHEBI:physostigmine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:physostigmine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(MESH:"Neuromuscular Junction"))) |
| pmid:19126755 | a(CHEBI:physostigmine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:18986241 | a(CHEBI:physostigmine) decreases path(MESH:D000544) |
| pmid:19126755 | a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:galanthamine) decreases path(HBP:Neurodegeneration) |
| pmid:19126755 | a(CHEBI:galanthamine) increases bp(GO:"synaptic transmission, cholinergic") |
| pmid:19126755 | a(CHEBI:galanthamine) decreases p(HGNC:ACHE) |
| pmid:11230871 | a(CHEBI:galanthamine) increases act(p(HGNC:ACHE)) |
| pmid:19293145 | a(CHEBI:galanthamine) isA a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") |
| pmid:19293145 | a(CHEBI:galanthamine) decreases path(MESH:"Alzheimer Disease") |
| pmid:19293145 | act(a(CHEBI:galanthamine)) increases bp(MESH:Neuroprotection) |
| pmid:19293145 | a(CHEBI:galanthamine) increases p(HGNC:BCL2) |
| pmid:24511233 | a(CHEBI:galanthamine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") |
| pmid:17009926 | a(CHEBI:galanthamine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") |
| pmid:17009926 | a(CHEBI:galanthamine) increases act(p(FPLX:CHRN)) |
| pmid:26813123 | a(CHEBI:galanthamine) decreases path(MESH:Death) |
| pmid:26813123 | a(CHEBI:galanthamine) increases bp(GO:cognition) |
| pmid:25881725 | a(CHEBI:galanthamine) decreases act(p(MGI:App, frag("25_35"))) |
| pmid:25881725 | a(CHEBI:galanthamine) increases bp(GO:learning) |
| pmid:25881725 | a(CHEBI:galanthamine) increases path(MESH:"Spatial Memory") |
| pmid:25881725 | a(CHEBI:galanthamine) causesNoChange r(MGI:Chrna7) |
| pmid:25881725 | a(CHEBI:galanthamine) increases p(MGI:Chrna7) |
| pmid:25881725 | a(CHEBI:galanthamine) increases p(MGI:Chrna7) |
| pmid:19721446 | a(CHEBI:galanthamine) regulates p(HGNC:CHRNA7) |
| pmid:19721446 | a(CHEBI:galanthamine) decreases path(MESH:Schizophrenia) |
| pmid:19126755 | a(CHEBI:"nicotinic antagonist") causesNoChange act(a(CHEBI:galanthamine)) |
| pmid:19126755 | a(CHEBI:"nicotinic antagonist") causesNoChange act(a(CHEBI:physostigmine)) |
| pmid:17009926 | a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:acetylcholine)) |
| pmid:17009926 | a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:dopamine)) |
| pmid:17009926 | a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:noradrenaline)) |
| pmid:17009926 | a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:serotonin)) |
| pmid:17009926 | a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:"glutamate(2-)")) |
| pmid:17009926 | a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:"gamma-aminobutyric acid")) |
| pmid:17009926 | a(CHEBI:"nicotinic antagonist") decreases bp(GO:memory) |
| pmid:19126755 | a(HBP:"FK1 antibody") decreases act(a(CHEBI:galanthamine)) |
| pmid:19126755 | a(HBP:"FK1 antibody") decreases act(a(CHEBI:physostigmine)) |
| pmid:19126755 | a(HBP:"FK1 antibody") decreases a(CHEBI:codeine) |
| pmid:19126755 | a(CHEBI:codeine) causesNoChange a(MESH:Cholinesterases) |
| pmid:19126755 | a(CHEBI:codeine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | path(MESH:Schizophrenia) negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | path(MESH:Schizophrenia) association path(MESH:"Sensory Gating") |
| pmid:19126755 | path(MESH:Schizophrenia) association path(MESH:"Sensory Gating") |
| pmid:24511233 | path(MESH:Schizophrenia) association path(MESH:"Psychotic Disorders") |
| pmid:24511233 | path(MESH:Schizophrenia) association path(MESH:"Cognitive Dysfunction") |
| pmid:24511233 | path(MESH:Schizophrenia) association path(MESH:Hallucinations) |
| pmid:19721446 | path(MESH:Schizophrenia) association path(MESH:Hallucinations) |
| pmid:24511233 | path(MESH:Schizophrenia) association path(MESH:Delusions) |
| pmid:19721446 | path(MESH:Schizophrenia) association path(MESH:Delusions) |
| pmid:24511233 | path(MESH:Schizophrenia) association bp(GO:cognition) |
| pmid:19721446 | path(MESH:Schizophrenia) association bp(GO:cognition) |
| pmid:24511233 | path(MESH:Schizophrenia) association bp(GO:behavior) |
| pmid:24511233 | path(MESH:Schizophrenia) decreases bp(GO:"synaptic transmission, cholinergic") |
| pmid:24511233 | path(MESH:Schizophrenia) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:24511233 | path(MESH:Schizophrenia) association path(MESH:"Memory, Short-Term") |
| pmid:24511233 | path(MESH:Schizophrenia) association path(MESH:Attention) |
| pmid:24511233 | path(MESH:Schizophrenia) association path(MESH:"Executive Function") |
| pmid:24511233 | path(MESH:Schizophrenia) association bp(GO:"synaptic transmission, glutamatergic") |
| pmid:24511233 | path(MESH:Schizophrenia) association bp(GO:"gamma-aminobutyric acid signaling pathway") |
| pmid:17009926 | path(MESH:Schizophrenia) association p(FPLX:CHRN) |
| pmid:17009926 | path(MESH:Schizophrenia) association p(FPLX:CHRN) |
| pmid:21482353 | path(MESH:Schizophrenia) association act(p(FPLX:CHRN)) |
| pmid:11230871 | path(MESH:Schizophrenia) association p(FPLX:CHRN) |
| pmid:21482353 | path(MESH:Schizophrenia) positiveCorrelation p(HGNC:CHRNA7, var("?")) |
| pmid:21482353 | path(MESH:Schizophrenia) association bp(GO:"GABAergic neuron differentiation") |
| pmid:21482353 | path(MESH:Schizophrenia) increases act(a(MESH:Hippocampus)) |
| pmid:21482353 | path(MESH:Schizophrenia) association g(HGNC:CHRFAM7A, var("?")) |
| pmid:21482353 | path(MESH:Schizophrenia) association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:21482353 | path(MESH:Schizophrenia) positiveCorrelation path(MESH:"Tobacco Use Disorder") |
| pmid:21482353 | path(MESH:Schizophrenia) association p(HGNC:PEMT, var("?")) |
| pmid:11230871 | path(MESH:Schizophrenia) negativeCorrelation a(HBP:"alpha-7-containing nAChR") |
| pmid:11230871 | path(MESH:Schizophrenia) causesNoChange a(HBP:"alpha-4-containing nAChR") |
| pmid:19721446 | path(MESH:Schizophrenia) association bp(MESH:"Sensory Gating") |
| pmid:19721446 | path(MESH:Schizophrenia) decreases p(HGNC:CHRNA7) |
| pmid:22040696 | path(MESH:Schizophrenia) negativeCorrelation p(HGNC:CHRNA7) |
| pmid:22040696 | path(MESH:Schizophrenia) positiveCorrelation r(HGNC:RIC3) |
| pmid:19126755 | path(MESH:"Sensory Gating") association g(HGNC:CHRNA7) |
| pmid:19126755 | path(MESH:"Sensory Gating") association path(MESH:Schizophrenia) |
| pmid:19126755 | path(MESH:"Sensory Gating") association path(MESH:Schizophrenia) |
| pmid:19126755 | path(MESH:"Sensory Gating") association act(p(HGNC:CHRNA7)) |
| pmid:19126755 | path(HBP:Neurodegeneration) negativeCorrelation p(MGI:Chrnb2) |
| pmid:24027553 | path(HBP:Neurodegeneration) association p(MGI:Mapt, var("p.P301L")) |
| pmid:17403556 | path(HBP:Neurodegeneration) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:19126755 | a(CHEBI:"kynurenic acid") negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:"kynurenic acid") decreases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pmid:19126755 | a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7)) |
| pmid:19126755 | a(CHEBI:"kynurenic acid") regulates act(p(HGNC:CHRNA7)) |
| pmid:19126755 | a(CHEBI:"kynurenic acid") regulates act(p(HGNC:CHRNA7)) |
| pmid:19126755 | a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7)) |
| pmid:19126755 | a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7)) |
| pmid:19126755 | a(CHEBI:"kynurenic acid") decreases act(p(MGI:Chrna7, loc(MESH:Interneurons))) |
| pmid:19126755 | a(CHEBI:"kynurenic acid") regulates bp(MESH:"Neuronal Plasticity") |
| pmid:19126755 | a(CHEBI:"kynurenic acid") regulates bp(GO:"synaptic transmission, cholinergic") |
| pmid:19126755 | a(CHEBI:"kynurenic acid") regulates path(MESH:"Cell Survival") |
| pmid:19126755 | a(CHEBI:"kynurenic acid") decreases a(CHEBI:dopamine, loc(GO:"extracellular region")) |
| pmid:19126755 | a(MESH:Astrocytes) increases a(CHEBI:"kynurenic acid") |
| pmid:23383175 | a(MESH:Astrocytes) positiveCorrelation a(MESH:Microglia) |
| pmid:23383175 | a(MESH:Astrocytes) negativeCorrelation a(GO:"myelin sheath") |
| pmid:28803412 | a(MESH:Astrocytes) increases deg(a(HBP:HBP00093)) |
| pmid:30108137 | a(MESH:Astrocytes) increases p(MGI:Tfeb) |
| pmid:30108137 | act(a(MESH:Astrocytes)) increases a(HBP:"Tau fibrils") |
| pmid:26195256 | act(a(MESH:Astrocytes)) decreases p(HGNC:APP) |
| pmid:26195256 | a(MESH:Astrocytes) decreases a(CHEBI:"amyloid-beta", loc(MESH:"Extracellular Fluid")) |
| pmid:27314526 | a(MESH:Astrocytes) increases p(HGNC:NLRP3) |
| pmid:27314526 | a(MESH:Astrocytes) increases p(HGNC:TLR4) |
| pmid:27314526 | a(MESH:Astrocytes) increases sec(p(HGNC:IL1B)) |
| pmid:19126755 | act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) increases a(CHEBI:anandamide) |
| pmid:24511233 | p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") regulates bp(MESH:"Neuronal Plasticity") |
| pmid:24511233 | p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") association bp(GO:cognition) |
| pmid:19126755 | a(CHEBI:"L-kynurenine") increases a(CHEBI:"kynurenic acid") |
| pmid:19126755 | a(MESH:Probenecid) decreases a(CHEBI:"kynurenic acid") |
| pmid:19126755 | bp(GO:"energy homeostasis") regulates a(CHEBI:"kynurenic acid") |
| pmid:19126755 | act(p(HGNC:AADAT), ma(cat)) increases a(CHEBI:"kynurenic acid") |
| pmid:19126755 | a(CHEBI:kynurenine) increases a(CHEBI:"kynurenic acid") |
| pmid:19126755 | a(CHEBI:kynurenine) increases a(CHEBI:"3-hydroxykynurenine") |
| pmid:19126755 | a(CHEBI:kynurenine) increases a(CHEBI:"quinolinic acid") |
| pmid:19623258 | a(CHEBI:"quinolinic acid") decreases p(HGNC:PPP2CA) |
| pmid:19623258 | a(CHEBI:"quinolinic acid") decreases p(HGNC:PPP1CA) |
| pmid:19623258 | a(CHEBI:"quinolinic acid") directlyIncreases act(complex(GO:"NMDA selective glutamate receptor complex")) |
| pmid:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:BRCA1) |
| pmid:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:MYC) |
| pmid:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:WNT1) |
| pmid:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:WISP1) |
| pmid:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:CDK5) |
| pmid:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:IL1A) |
| pmid:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:NOS2) |
| pmid:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:CEBPB) |
| pmid:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:CSF2) |
| pmid:19623258 | a(CHEBI:"quinolinic acid") increases r(HGNC:LEP) |
| pmid:19126755 | act(p(MGI:Chrna7, loc(MESH:Interneurons))) increases act(a(MESH:"GABAergic Neurons")) |
| pmid:19126755 | p(MGI:Chrna7) negativeCorrelation path(MESH:Aging) |
| pmid:19293145 | p(MGI:Chrna7) increases bp(MESH:"Neuronal Outgrowth") |
| pmid:25514383 | p(MGI:Chrna7) decreases path(MESH:"Spatial Memory") |
| pmid:25881725 | act(p(MGI:Chrna7)) increases path(MESH:"Spatial Memory") |
| pmid:25514383 | p(MGI:Chrna7) decreases p(MGI:Syp) |
| pmid:25514383 | p(MGI:Chrna7) decreases p(MGI:Map2) |
| pmid:25514383 | p(MGI:Chrna7) increases p(MGI:Map2) |
| pmid:25514383 | p(MGI:Chrna7) increases a(CHEBI:"amyloid-beta") |
| pmid:25514383 | p(MGI:Chrna7) decreases a(CHEBI:"amyloid-beta") |
| pmid:25514383 | p(MGI:Chrna7) increases bp(GO:cognition) |
| pmid:25514383 | p(MGI:Chrna7) decreases path(MESH:"Cognition Disorders") |
| pmid:25514383 | p(MGI:Chrna7) increases path(MESH:"Plaque, Amyloid") |
| pmid:27522251 | p(MGI:Chrna7) decreases path(MESH:"Memory Disorders") |
| pmid:27522251 | p(MGI:Chrna7) decreases path(MESH:"Memory Disorders") |
| pmid:27522251 | p(MGI:Chrna7) decreases path(MESH:"Cognitive Dysfunction") |
| pmid:27522251 | p(MGI:Chrna7) association bp(GO:aging) |
| pmid:27522251 | p(MGI:Chrna7) increases a(HBP:HBP00022) |
| pmid:25881725 | act(p(MGI:Chrna7)) increases bp(GO:learning) |
| pmid:25881725 | p(MGI:Chrna7) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28901280 | p(MGI:Chrna7) association act(a(MESH:Epithelium)) |
| pmid:21482353 | a(MESH:"GABAergic Neurons") positiveCorrelation a(HBP:"alpha-4 beta-2 nAChR") |
| pmid:19126755 | bp(MESH:"Neuronal Plasticity") association act(p(FPLX:CREB)) |
| pmid:19126755 | bp(MESH:"Neuronal Plasticity") association act(p(HGNC:MAPK1)) |
| pmid:24760868 | bp(MESH:"Neuronal Plasticity") association tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) |
| pmid:28420982 | bp(MESH:"Neuronal Plasticity") increases tloc(p(HGNC:MAPT), fromLoc(GO:cell), toLoc(GO:cell)) |
| pmid:28420982 | bp(MESH:"Neuronal Plasticity") association a(HBP:"Tau aggregates") |
| pmid:19126755 | a(MESH:"Mossy Fibers, Hippocampal") increases a(CHEBI:"glutamate(2-)", loc(MESH:"Pyramidal Cells")) |
| pmid:19126755 | a(MESH:"7-chlorothiokynurenic acid") causesNoChange a(CHEBI:dopamine, loc(GO:"extracellular region")) |
| pmid:19126755 | a(CHEBI:donepezil) decreases p(HGNC:ACHE) |
| pmid:11230871 | a(CHEBI:donepezil) increases act(p(HGNC:ACHE)) |
| pmid:19293145 | a(CHEBI:donepezil) isA a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") |
| pmid:19293145 | a(CHEBI:donepezil) decreases path(MESH:"Alzheimer Disease") |
| pmid:19293145 | a(CHEBI:donepezil) decreases path(HBP:neurotoxicity) |
| pmid:19293145 | a(CHEBI:donepezil) decreases path(HBP:neurotoxicity) |
| pmid:19293145 | a(CHEBI:donepezil) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | a(CHEBI:donepezil) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | a(CHEBI:donepezil) increases p(HGNC:CHRNA4) |
| pmid:19293145 | a(CHEBI:donepezil) increases p(HGNC:CHRNA7) |
| pmid:19293145 | a(CHEBI:donepezil) increases bp(MESH:Neuroprotection) |
| pmid:19293145 | a(CHEBI:donepezil) increases p(HGNC:BCL2) |
| pmid:24511233 | a(CHEBI:donepezil) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") |
| pmid:26813123 | a(CHEBI:donepezil) increases bp(GO:cognition) |
| pmid:18986241 | a(CHEBI:donepezil) increases act(a(MESH:D005625)) |
| pmid:29626319 | a(CHEBI:donepezil) increases p(HGNC:ABCB1) |
| pmid:29626319 | a(CHEBI:donepezil) increases p(HGNC:LRP1) |
| pmid:29626319 | a(CHEBI:donepezil) decreases a(CHEBI:"amyloid-beta") |
| pmid:19126755 | a(CHEBI:rivastigmine) decreases p(HGNC:ACHE) |
| pmid:11230871 | a(CHEBI:rivastigmine) increases act(p(HGNC:ACHE)) |
| pmid:19293145 | a(CHEBI:rivastigmine) isA a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") |
| pmid:19293145 | a(CHEBI:rivastigmine) decreases path(MESH:"Alzheimer Disease") |
| pmid:26813123 | a(CHEBI:rivastigmine) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | a(CHEBI:rivastigmine) decreases path(HBP:neurotoxicity) |
| pmid:19293145 | a(CHEBI:rivastigmine) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:24511233 | a(CHEBI:rivastigmine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") |
| pmid:29626319 | a(CHEBI:rivastigmine) increases p(HGNC:ABCB1) |
| pmid:29626319 | a(CHEBI:rivastigmine) increases p(HGNC:LRP1) |
| pmid:29626319 | a(CHEBI:rivastigmine) decreases a(CHEBI:"amyloid-beta") |
| pmid:19126755 | a(CHEBI:anandamide) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19126755 | a(CHEBI:anandamide) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | a(CHEBI:anandamide) association p(HGNC:CNR1) |
| pmid:19126755 | a(CHEBI:anandamide) association p(HGNC:CNR2) |
| pmid:19126755 | a(CHEBI:anandamide) association complex(GO:"voltage-gated calcium channel complex") |
| pmid:19126755 | a(CHEBI:anandamide) association p(HGNCGENEFAMILY:"Potassium voltage-gated channels") |
| pmid:19126755 | a(CHEBI:anandamide) association a(MESH:"Receptors, Serotonin") |
| pmid:19126755 | a(CHEBI:anandamide) association p(HGNCGENEFAMILY:"Glutamate ionotropic receptor kainate type subunits") |
| pmid:19126755 | a(CHEBI:anandamide) decreases act(p(HGNC:CHRNA7)) |
| pmid:19126755 | a(CHEBI:anandamide) decreases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19126755 | a(CHEBI:anandamide) regulates bp(GO:"chemical synaptic transmission, postsynaptic") |
| pmid:19126755 | p(HBP:"gamma-secretase") increases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:19293145 | complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) decreases act(a(MESH:Bungarotoxins)) |
| pmid:17009926 | complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) association path(MESH:"Alzheimer Disease") |
| pmid:25514383 | complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) association path(MESH:"Plaque, Amyloid") |
| pmid:19126755 | p(HGNC:CNR1) association a(CHEBI:anandamide) |
| pmid:19126755 | p(HGNC:CNR2) association a(CHEBI:anandamide) |
| pmid:19126755 | a(MESH:"Receptors, Serotonin") association a(CHEBI:anandamide) |
| pmid:19126755 | p(HGNCGENEFAMILY:"Glutamate ionotropic receptor kainate type subunits") association a(CHEBI:anandamide) |
| pmid:19126755 | a(CHEBI:bupropion) decreases act(p(HGNC:CHRNA7)) |
| pmid:19126755 | a(CHEBI:bupropion) decreases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19126755 | a(CHEBI:bupropion) decreases act(p(HBP:"alpha-3 beta-4 nAChR")) |
| pmid:19126755 | a(CHEBI:bupropion) association path(MESH:"Smoking Cessation") |
| pmid:19126755 | a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(HGNC:CHRNA7)) |
| pmid:19126755 | a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19126755 | a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(HBP:"alpha-3 beta-4 nAChR")) |
| pmid:19126755 | path(MESH:"Smoking Cessation") association a(CHEBI:bupropion) |
| pmid:17009926 | bp(GO:"membrane depolarization") increases act(complex(GO:"voltage-gated calcium channel complex")) |
| pmid:26813123 | bp(GO:"membrane depolarization") regulates act(p(HGNC:CHAT)) |
| pmid:26813123 | bp(GO:"membrane depolarization") increases tloc(a(CHEBI:acetylcholine), fromLoc(MESH:"Synaptic Vesicles"), toLoc(GO:"synaptic cleft")) |
| pmid:26813123 | bp(GO:"membrane depolarization") increases complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) |
| pmid:24590577 | bp(GO:"neuron differentiation") association p(HGNC:CHRM1) |
| pmid:28884684 | bp(GO:"neuron differentiation") positiveCorrelation act(p(HGNC:DYRK1A), ma(kin)) |
| pmid:19293145 | p(FPLX:PI3K) increases act(a(CHEBI:nicotine)) |
| pmid:19293145 | act(p(FPLX:PI3K)) increases act(a(MESH:"Cholinesterase Inhibitors")) |
| pmid:19293145 | act(p(FPLX:PI3K)) increases act(p(HGNC:BAD)) |
| pmid:19293145 | p(FPLX:PI3K) increases act(a(MESH:Synapses)) |
| pmid:19293145 | act(p(FPLX:PI3K)) decreases bp(GO:"apoptotic process") |
| pmid:19293145 | p(FPLX:PI3K) regulates act(a(CHEBI:estrogen)) |
| pmid:22040696 | act(p(FPLX:PI3K)) decreases bp(GO:"neuron death") |
| pmid:30116051 | act(p(FPLX:PI3K)) increases a(GO:"autophagosome membrane") |
| pmid:26813123 | p(FPLX:PKA) increases p(FPLX:CHRN, pmod(Ph)) |
| pmid:30116051 | act(p(FPLX:PKA), ma(kin)) increases p(HGNC:PSMC5, pmod(Ph, Ser, 120)) |
| pmid:17493042 | p(FPLX:PKA) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) |
| pmid:17078951 | p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:17078951 | p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:17078951 | p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:17078951 | p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:17078951 | p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 217)) |
| pmid:17078951 | p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17078951 | p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:17078951 | p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:17078951 | p(FPLX:PKA) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:17078951 | p(FPLX:PKA) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 212)) |
| pmid:17078951 | p(FPLX:PKA) decreases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 202))) |
| pmid:17078951 | p(FPLX:PKA) decreases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 212))) |
| pmid:17078951 | p(FPLX:PKA) decreases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 217))) |
| pmid:17078951 | p(FPLX:PKA) decreases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 404))) |
| pmid:17078951 | p(FPLX:PKA) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 396))) |
| pmid:23001711 | act(p(FPLX:PKA), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:26692334 | act(p(FPLX:PKA)) positiveCorrelation a(CHEBI:rolipram) |
| pmid:26692334 | act(p(FPLX:PKA)) positiveCorrelation act(complex(GO:"proteasome complex")) |
| pmid:19721446 | act(p(FPLX:"CAMK2_complex")) increases act(a(CHEBI:nicotine)) |
| pmid:23001711 | p(FPLX:"CAMK2_complex") increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:19293145 | act(p(HGNC:STAT3)) association p(HGNC:JAK2) |
| pmid:19293145 | act(p(HGNC:STAT3)) association act(a(CHEBI:nicotine)) |
| pmid:30116051 | p(HGNC:STAT3) decreases bp(GO:macroautophagy) |
| pmid:19126755 | act(p(HGNC:MAPK1)) association bp(MESH:"Neuronal Plasticity") |
| pmid:19126755 | act(p(HGNC:MAPK1)) association path(MESH:"Tobacco Use Disorder") |
| pmid:19293145 | act(p(HGNC:MAPK1)) increases bp(GO:"apoptotic process") |
| pmid:28784767 | act(p(HGNC:MAPK1)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:28784767 | act(p(HGNC:MAPK1)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:25001178 | act(p(HGNC:MAPK1), ma(kin)) negativeCorrelation act(p(HGNC:DUSP6)) |
| pmid:25001178 | act(p(HGNC:MAPK1), ma(kin)) positiveCorrelation act(p(HGNC:CDK5), ma(kin)) |
| pmid:19126755 | path(MESH:"Tobacco Use Disorder") association act(p(HGNC:MAPK1)) |
| pmid:19126755 | path(MESH:"Tobacco Use Disorder") association act(p(FPLX:CREB)) |
| pmid:19126755 | path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Wound Healing") |
| pmid:19126755 | path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Wound Healing") |
| pmid:19126755 | path(MESH:"Tobacco Use Disorder") association path(MESH:Infection) |
| pmid:19126755 | path(MESH:"Tobacco Use Disorder") association path(MESH:"Skin Aging") |
| pmid:19126755 | path(MESH:"Tobacco Use Disorder") increases path(MESH:"Skin Aging") |
| pmid:19126755 | path(MESH:"Tobacco Use Disorder") association path(MESH:Neoplasms) |
| pmid:19126755 | path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Colitis, Ulcerative") |
| pmid:19126755 | path(MESH:"Tobacco Use Disorder") increases path(MESH:"Crohn Disease") |
| pmid:19126755 | path(MESH:"Tobacco Use Disorder") association path(MESH:"Insulin Resistance") |
| pmid:19126755 | path(MESH:"Tobacco Use Disorder") negativeCorrelation path(MESH:"Parkinson Disease") |
| pmid:28445721 | path(MESH:"Tobacco Use Disorder") association p(FPLX:CHRN) |
| pmid:21482353 | path(MESH:"Tobacco Use Disorder") association act(p(FPLX:CHRN)) |
| pmid:21482353 | path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA5, var("?")) |
| pmid:21482353 | path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA5, var("?")) |
| pmid:21482353 | path(MESH:"Tobacco Use Disorder") positiveCorrelation path(MESH:Schizophrenia) |
| pmid:21482353 | path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA3, var("?")) |
| pmid:21482353 | path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNB4, var("?")) |
| pmid:21482353 | path(MESH:"Tobacco Use Disorder") increases act(a(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:21787755 | path(MESH:"Tobacco Use Disorder") association a(HBP:AβOs) |
| pmid:21787755 | path(MESH:"Tobacco Use Disorder") association a(HBP:"alpha-4 beta-4 nAChR") |
| pmid:21787755 | path(MESH:"Tobacco Use Disorder") association a(HBP:"alpha-6-containing nAChR") |
| pmid:28901280 | path(MESH:"Tobacco Use Disorder") association g(DNSNP:rs1051730) |
| pmid:19126755 | bp(GO:"receptor signaling pathway via JAK-STAT") increases act(a(CHEBI:nicotine)) |
| pmid:19126755 | a(MESH:Skin) association act(a(CHEBI:nicotine)) |
| pmid:29626319 | a(MESH:Skin) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(MESH:Skin) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:29626319 | a(MESH:Skin) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:19126755 | path(MESH:Infection) association path(MESH:"Tobacco Use Disorder") |
| pmid:19126755 | path(MESH:"Skin Aging") association path(MESH:"Tobacco Use Disorder") |
| pmid:19126755 | path(MESH:Neoplasms) association path(MESH:"Tobacco Use Disorder") |
| pmid:28901280 | path(MESH:Neoplasms) association p(HGNC:CHRNA7) |
| pmid:25784053 | path(MESH:Neoplasms) association act(p(HGNC:HSF1)) |
| pmid:29311797 | path(MESH:Neoplasms) association p(HGNC:STUB1) |
| pmid:30126037 | bp(GO:"cell cycle") association bp(GO:"cellular senescence") |
| pmid:19126755 | path(MESH:"Insulin Resistance") association path(MESH:"Tobacco Use Disorder") |
| pmid:19126755 | path(MESH:"Insulin Resistance") increases path(MESH:"Diabetes Mellitus, Type 1") |
| pmid:21718217 | path(MESH:"Insulin Resistance") association p(HGNC:PPARGC1A) |
| pmid:19126755 | path(MESH:"Genetic Variation") association act(a(CHEBI:nicotine)) |
| pmid:19126755 | a(MESH:"Mice, Inbred Strains") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | a(MESH:"Mice, Inbred Strains") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | a(MESH:"Rats, Inbred Strains") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19126755 | path(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24511233 | path(MESH:"Neurofibrillary Tangles") biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:24590577 | path(MESH:"Neurofibrillary Tangles") association path(MESH:"Alzheimer Disease") |
| pmid:24027553 | path(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24590577 | path(MESH:"Neurofibrillary Tangles") association bp(GO:"synaptic transmission, cholinergic") |
| pmid:24027553 | path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(Ph)) |
| pmid:24027553 | path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(Ac)) |
| pmid:24027553 | path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(HBP:nitration)) |
| pmid:24027553 | path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, frag("1_?")) |
| pmid:24027553 | path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, frag("?_*")) |
| pmid:24027553 | path(MESH:"Neurofibrillary Tangles") association a(CHEBI:Thrombin) |
| pmid:24027553 | path(MESH:"Neurofibrillary Tangles") positiveCorrelation p(HGNC:CAPN2) |
| pmid:24027553 | path(MESH:"Neurofibrillary Tangles") positiveCorrelation act(p(HGNCGENEFAMILY:Caspases)) |
| pmid:24027553 | path(MESH:"Neurofibrillary Tangles") association act(p(HGNCGENEFAMILY:Caspases)) |
| pmid:24027553 | path(MESH:"Neurofibrillary Tangles") positiveCorrelation p(HGNC:MAPT, pmod(Ub)) |
| pmid:19126755 | path(MESH:"Neurogenic Inflammation") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19126755 | p(MGI:Chrnb2) negativeCorrelation path(HBP:Neurodegeneration) |
| pmid:25514383 | p(MGI:Chrnb2) regulates bp(MESH:Homeostasis) |
| pmid:25514383 | p(MGI:Chrnb2) increases a(MESH:"Cerebral Cortex") |
| pmid:25514383 | p(MGI:Chrnb2) increases path(MESH:Attention) |
| pmid:25514383 | p(MGI:Chrnb2) increases bp(GO:cognition) |
| pmid:27522251 | p(MGI:Chrnb2) decreases path(MESH:"Memory Disorders") |
| pmid:27522251 | p(MGI:Chrnb2) increases a(CHEBI:"amyloid-beta") |
| pmid:19126755 | p(MGI:Chrna4) negativeCorrelation path(MESH:Aging) |
| pmid:19126755 | a(HBP:"amyloid-beta oligomers") regulates act(p(HGNC:CHRNA7)) |
| pmid:19293145 | a(HBP:"amyloid-beta oligomers") isA a(CHEBI:"amyloid-beta") |
| pmid:19293145 | a(HBP:"amyloid-beta oligomers") positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pmid:19293145 | a(HBP:"amyloid-beta oligomers") association path(HBP:neurotoxicity) |
| pmid:19293145 | a(HBP:"amyloid-beta oligomers") directlyIncreases path(HBP:neurotoxicity) |
| pmid:19293145 | a(HBP:"amyloid-beta oligomers") increases act(p(FPLX:JNK)) |
| pmid:19293145 | a(HBP:"amyloid-beta oligomers") decreases act(p(FPLX:ERK)) |
| pmid:26813123 | a(HBP:"amyloid-beta oligomers") association act(a(GO:"cholinergic synapse")) |
| pmid:17403556 | a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:17403556 | a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, loc(MESH:"Post-Synaptic Density")) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") decreases p(HGNC:MAPT, loc(GO:synapse)) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") increases tloc(p(HGNC:MAPT)) |
| pmid:23528736 | a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") increases p(HGNC:DLG4) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") decreases p(HGNC:DLG4, loc(GO:synapse)) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") increases p(HGNC:GRIA1) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") increases p(HGNC:FYN) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") decreases bp(GO:"actin filament polymerization") |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") decreases a(MESH:Actins, loc(GO:synapse)) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") decreases complex(a(MESH:"Dendritic Spines"), p(HGNC:MAPT)) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") regulates p(HGNC:MAPT, pmod(Ph)) |
| pmid:22419736 | a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24760868 | a(HBP:"amyloid-beta oligomers") causesNoChange p(HGNC:MAPT, var("p.S404A"), loc(MESH:"Dendritic Spines")) |
| pmid:23528736 | a(HBP:"amyloid-beta oligomers") decreases act(p(FPLX:Proteasome)) |
| pmid:22156579 | act(a(HBP:"amyloid-beta oligomers")) positiveCorrelation p(INTERPRO:"Kinase associated domain 1 (KA1)") |
| pmid:19126755 | a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases act(p(HGNC:PTGS1)) |
| pmid:19126755 | a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases act(p(HGNC:PTGS2)) |
| pmid:19126755 | act(p(HGNC:PTGS1)) increases a(CHEBI:"prostaglandin H2") |
| pmid:19126755 | act(p(HGNC:PTGS2)) increases a(CHEBI:"prostaglandin H2") |
| pmid:19126755 | p(HGNC:PTGS2, loc(MESH:Neurons)) regulates path(MESH:"Neuronal Plasticity") |
| pmid:19126755 | p(HGNC:PTGS2, loc(MESH:Neurons)) regulates bp(GO:"cell death") |
| pmid:19126755 | p(HGNC:PTGS2) association p(HGNC:CHRNA4) |
| pmid:19126755 | a(CHEBI:"NS-398") decreases p(HGNC:CHRNA4) |
| pmid:19126755 | path(MESH:Tremor) positiveCorrelation path(MESH:"Parkinson Disease") |
| pmid:19126755 | path(MESH:Hypokinesia) positiveCorrelation path(MESH:"Parkinson Disease") |
| pmid:19126755 | path(MESH:"Muscle Rigidity") positiveCorrelation path(MESH:"Parkinson Disease") |
| pmid:17009926 | path(MESH:"Behavior, Addictive") association p(FPLX:CHRN) |
| pmid:19721446 | path(MESH:Craving) association p(HGNC:CHRNA3) |
| pmid:19721446 | path(MESH:Craving) association p(HGNC:CHRNB4) |
| pmid:17009926 | path(MESH:Anxiety) association p(FPLX:CHRN) |
| pmid:11230871 | path(MESH:Anxiety) association p(FPLX:CHRN) |
| pmid:21482353 | path(MESH:Anxiety) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:28901280 | path(MESH:Anxiety) association p(MESH:"Receptors, Nicotinic") |
| pmid:28775333 | path(MESH:Anxiety) positiveCorrelation p(MGI:Dyrk1a) |
| pmid:19126755 | a(HBP:"beta-2-containing nAChR") association a(CHEBI:nicotine) |
| pmid:19126755 | a(HBP:"beta-2-containing nAChR") causesNoChange act(a(CHEBI:nicotine)) |
| pmid:19126755 | path(MESH:"Drug Tolerance") association p(HGNC:CHRNB4) |
| pmid:19126755 | path(MESH:"Drug Tolerance") association a(HBP:"alpha-4-containing nAChR") |
| pmid:19126755 | a(HBP:"alpha-4-containing nAChR") association path(MESH:"Drug Tolerance") |
| pmid:11230871 | a(HBP:"alpha-4-containing nAChR") negativeCorrelation bp(GO:aging) |
| pmid:11230871 | a(HBP:"alpha-4-containing nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | path(MESH:Death) association path(MESH:"Alzheimer Disease") |
| pmid:19293145 | a(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT) |
| pmid:14556719 | a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT) |
| pmid:14556719 | a(MESH:"Neurofibrillary Tangles") increases p(HGNC:MAPT) |
| pmid:27574109 | a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT) |
| pmid:14556719 | a(MESH:"Neurofibrillary Tangles") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) |
| pmid:14556719 | a(MESH:"Neurofibrillary Tangles") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) |
| pmid:14556719 | a(MESH:"Neurofibrillary Tangles") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:27574109 | a(MESH:"Neurofibrillary Tangles") association a(HBP:"Tau oligomers") |
| pmid:27574109 | a(MESH:"Neurofibrillary Tangles") association a(HBP:"phosphatase-activating domain") |
| pmid:23528736 | a(MESH:"Neurofibrillary Tangles") association p(HBP:"UBB+1") |
| pmid:19293145 | a(HBP:"amyloid-beta aggregates") association path(MESH:"Alzheimer Disease") |
| pmid:24590577 | a(HBP:"amyloid-beta aggregates") increases path(MESH:"Alzheimer Disease") |
| pmid:25514383 | a(HBP:"amyloid-beta aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22817713 | a(HBP:"amyloid-beta aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24511233 | a(HBP:"amyloid-beta aggregates") association path(MESH:"Plaque, Amyloid") |
| pmid:24590577 | a(HBP:"amyloid-beta aggregates") increases path(MESH:"Plaque, Amyloid") |
| pmid:17009926 | a(HBP:"amyloid-beta aggregates") association p(HGNC:CHRNA7) |
| pmid:19293145 | a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") decreases path(MESH:"Alzheimer Disease") |
| pmid:19293145 | a(CHEBI:memantine) isA a(CHEBI:"NMDA receptor antagonist") |
| pmid:19293145 | a(CHEBI:memantine) decreases path(MESH:"Alzheimer Disease") |
| pmid:23722080 | a(CHEBI:memantine) decreases path(MESH:"Alzheimer Disease") |
| pmid:26813123 | a(CHEBI:memantine) decreases a(HBP:Excitotoxicity) |
| pmid:16273023 | a(CHEBI:memantine) decreases complex(a(CHEBI:"calcium(2+)"), p(GFAM:"Glutamate ionotropic receptor NMDA type subunits")) |
| pmid:16273023 | a(CHEBI:memantine) causesNoChange bp(MESH:D009435) |
| pmid:23722080 | a(CHEBI:memantine) decreases p(RGD:Mapt, pmod(Ph, Ser, 262)) |
| pmid:23722080 | a(CHEBI:memantine) decreases p(RGD:Mapt, pmod(Ph, Ser, 404)) |
| pmid:23722080 | a(CHEBI:memantine) increases bp(GO:"cellular metabolic process") |
| pmid:16273023 | a(CHEBI:"NMDA receptor antagonist") association bp(GO:"GO:0035249") |
| pmid:16273023 | a(CHEBI:"NMDA receptor antagonist") decreases act(a(MESH:D009474)) |
| pmid:21882945 | a(CHEBI:"NMDA receptor antagonist") positiveCorrelation bp(GO:cognition) |
| pmid:19293145 | composite(p(HBP:"gamma-secretase"), p(HGNC:APP), p(HGNC:BACE1)) directlyIncreases composite(a(CHEBI:"amyloid-beta polypeptide 40"), a(CHEBI:"amyloid-beta polypeptide 42")) |
| pmid:19293145 | a(HBP:"amyloid-beta fibrils") isA a(CHEBI:"amyloid-beta") |
| pmid:17403556 | a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:17403556 | a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17403556 | a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17403556 | a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:17403556 | a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:17403556 | a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:19293145 | a(HBP:"Abeta*56") decreases path(MESH:"Maze Learning") |
| pmid:19293145 | p(HGNC:BCHE) decreases a(CHEBI:acetylcholine) |
| pmid:18986241 | act(p(HGNC:BCHE), ma(cat)) directlyIncreases deg(a(CHEBI:acetylcholine)) |
| pmid:18986241 | p(HGNC:BCHE) association a(MESH:D016874) |
| pmid:18986241 | p(HGNC:BCHE) association path(MESH:D058225) |
| pmid:18986241 | p(HGNC:BCHE) association path(MESH:D003071) |
| pmid:19293145 | g(HGNC:CHAT) association path(MESH:"Alzheimer Disease") |
| pmid:19293145 | g(HGNC:ACHE) association path(MESH:"Alzheimer Disease") |
| pmid:19293145 | bp(MESH:Neuroprotection) association p(HGNC:FYN) |
| pmid:19293145 | bp(MESH:Neuroprotection) association bp(GO:"calcium-mediated signaling") |
| pmid:19293145 | bp(MESH:Neuroprotection) association a(MESH:Calcineurin) |
| pmid:19293145 | bp(MESH:Neuroprotection) association p(HGNC:JAK2) |
| pmid:19721446 | bp(MESH:Neuroprotection) association p(HGNC:CHRNA7) |
| pmid:19721446 | bp(MESH:Neuroprotection) association a(CHEBI:nicotine) |
| pmid:19293145 | a(CHEBI:"dihydro-beta-erythroidine") decreases act(a(CHEBI:nicotine)) |
| pmid:19293145 | a(CHEBI:"dihydro-beta-erythroidine") decreases act(a(CHEBI:nicotine)) |
| pmid:19293145 | a(CHEBI:"dihydro-beta-erythroidine") decreases act(a(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19293145 | a(CHEBI:"dihydro-beta-erythroidine") decreases bp(MESH:Neuroprotection) |
| pmid:17009926 | a(CHEBI:"dihydro-beta-erythroidine") decreases act(p(HGNC:CHRNB2)) |
| pmid:17009926 | a(CHEBI:"dihydro-beta-erythroidine") decreases bp(GO:memory) |
| pmid:19293145 | a(CHEBI:Mecamylamine) decreases act(a(CHEBI:nicotine)) |
| pmid:17009926 | a(CHEBI:Mecamylamine) isA a(CHEBI:"nicotinic antagonist") |
| pmid:17009926 | a(CHEBI:Mecamylamine) decreases path(MESH:Attention) |
| pmid:26813123 | a(CHEBI:Mecamylamine) decreases act(a(MESH:"Hypothalamo-Hypophyseal System")) |
| pmid:11230871 | a(CHEBI:Mecamylamine) decreases bp(GO:cognition) |
| pmid:19721446 | a(CHEBI:Mecamylamine) decreases bp(GO:cognition) |
| pmid:23038257 | bp(GO:"intracellular receptor signaling pathway") association p(HGNC:CHRNA4) |
| pmid:19293145 | a(MESH:Bungarotoxins) decreases act(a(CHEBI:"amyloid-beta")) |
| pmid:19293145 | a(MESH:Bungarotoxins) decreases complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) |
| pmid:19293145 | act(a(MESH:Bungarotoxins)) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:23038257 | a(MESH:Bungarotoxins) decreases bp(GO:"neuromuscular synaptic transmission") |
| pmid:23038257 | a(MESH:Bungarotoxins) decreases act(a(MESH:"Electric Organ")) |
| pmid:23038257 | a(MESH:Bungarotoxins) decreases act(a(CHEBI:decamethonium)) |
| pmid:25514383 | a(MESH:Bungarotoxins) decreases complex(a(CHEBI:"amyloid-beta"), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28445721 | a(MESH:Bungarotoxins) decreases complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:19293145 | composite(a(CHEBI:"3',5'-cyclic AMP"), p(FPLX:PKC)) regulates act(a(CHEBI:nicotine)) |
| pmid:19293145 | act(a(CHEBI:ethanol)) increases path(HBP:neurotoxicity) |
| pmid:19293145 | a(MESH:Serum) decreases bp(GO:"cell death") |
| pmid:24027553 | bp(HBP:Excitotoxicity) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) |
| pmid:24183963 | a(CHEBI:glucose) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:24183963 | a(CHEBI:glucose) decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:16630055 | a(CHEBI:glucose) negativeCorrelation path(MESH:Fasting) |
| pmid:19293145 | a(CHEBI:thapsigargin) increases bp(GO:"cell death") |
| pmid:19293145 | a(CHEBI:thapsigargin) decreases bp(GO:"sarcoplasmic reticulum calcium ion transport") |
| pmid:29024336 | a(CHEBI:thapsigargin) increases bp(GO:"response to endoplasmic reticulum stress") |
| pmid:19293145 | act(a(CHEBI:"L-glutamate(2-)")) increases path(HBP:neurotoxicity) |
| pmid:19293145 | act(a(CHEBI:"L-glutamate(2-)")) increases path(HBP:neurotoxicity) |
| pmid:19293145 | a(CHEBI:"N-methyl-4-phenylpyridinium") increases path(HBP:neurotoxicity) |
| pmid:19293145 | act(a(CHEBI:methamphetamine)) increases bp(HBP:Neurodegeneration) |
| pmid:26813123 | bp(HBP:Neurodegeneration) negativeCorrelation bp(GO:memory) |
| pmid:26813123 | bp(HBP:Neurodegeneration) association bp(GO:"synaptic transmission, glutamatergic") |
| pmid:26813123 | bp(HBP:Neurodegeneration) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:18986241 | bp(HBP:Neurodegeneration) association path(MESH:D060825) |
| pmid:19293145 | act(a(MESH:"Vagus Nerve")) increases act(p(HGNC:CHRNA7)) |
| pmid:19293145 | act(p(HGNC:FAS)) increases bp(GO:"programmed cell death") |
| pmid:23702978 | act(p(HGNC:FAS)) increases act(p(HGNC:IL1B)) |
| pmid:23702978 | act(p(HGNC:FAS)) increases act(p(HGNC:CASP8)) |
| pmid:19293145 | bp(GO:"negative regulation of apoptotic process") association a(CHEBI:nicotine) |
| pmid:19293145 | p(FPLX:SRC) increases act(a(CHEBI:nicotine)) |
| pmid:17009926 | act(p(FPLX:SRC), ma(kin)) increases p(HGNC:CHRNA7, pmod(Ph)) |
| pmid:22040696 | act(p(FPLX:SRC), ma(kin)) increases p(FPLX:CHRN, pmod(Ph, Tyr)) |
| pmid:22040696 | act(p(FPLX:SRC), ma(kin)) increases p(FPLX:CHRN, pmod(Ph, Tyr)) |
| pmid:25514383 | p(FPLX:AKT, pmod(Ph)) decreases bp(GO:"apoptotic process") |
| pmid:19293145 | act(p(FPLX:AKT)) decreases bp(GO:"apoptotic process") |
| pmid:19293145 | p(FPLX:AKT) association bp(GO:"insulin receptor signaling pathway") |
| pmid:25514383 | act(p(FPLX:AKT)) decreases bp(HP:Neurodegeneration) |
| pmid:29121589 | p(FPLX:AKT) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:29121589 | p(FPLX:AKT) positiveCorrelation p(HGNC:NFE2L2) |
| pmid:23528736 | p(HGNC:BCL2) decreases bp(GO:autophagy) |
| pmid:19293145 | a(MESH:"Nicotinic Antagonists") decreases bp(MESH:Neuroprotection) |
| pmid:19293145 | a(CHEBI:tacrine) increases p(HGNC:BCL2) |
| pmid:19293145 | act(a(CHEBI:tacrine)) negativeCorrelation g(HGNC:APOE) |
| pmid:24511233 | a(CHEBI:tacrine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") |
| pmid:11230871 | a(CHEBI:tacrine) increases act(p(HGNC:ACHE)) |
| pmid:11230871 | a(CHEBI:tacrine) increases act(p(HGNC:ACHE)) |
| pmid:11230871 | a(CHEBI:tacrine) increases p(FPLX:CHRN) |
| pmid:19293145 | tloc(p(HGNC:BAX), fromLoc(GO:cytosol), toLoc(GO:mitochondrion)) increases bp(GO:"apoptotic process") |
| pmid:19293145 | p(HGNC:FYN) association p(HGNC:MAPT, pmod(Ph)) |
| pmid:18680553 | p(HGNC:FYN) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:19293145 | p(HGNC:FYN) increases bp(GO:cognition) |
| pmid:19293145 | p(HGNC:FYN) increases act(p(FPLX:PI3K)) |
| pmid:19293145 | p(HGNC:FYN) increases p(HGNC:AGAP2, pmod(Ph)) |
| pmid:19293145 | p(HGNC:FYN) decreases bp(GO:"apoptotic process") |
| pmid:19293145 | p(HGNC:FYN) association bp(MESH:Neuroprotection) |
| pmid:19293145 | p(HGNC:FYN) increases bp(MESH:Neuroprotection) |
| pmid:19293145 | p(HGNC:FYN) association act(a(CHEBI:"amyloid-beta")) |
| pmid:19293145 | p(HGNC:FYN) increases complex(p(HGNC:FYN), p(HGNC:PTK2)) |
| pmid:19293145 | p(HGNC:FYN) increases p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors", pmod(Ph)) |
| pmid:19293145 | p(HGNC:FYN) increases p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors", pmod(Ph)) |
| pmid:24760868 | p(HGNC:FYN, loc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pmid:26751493 | p(HGNC:FYN) association p(HBP:"projection domain") |
| pmid:17493042 | p(HGNC:FYN) increases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) |
| pmid:18680553 | p(HGNC:FYN) association p(HGNC:MAPT) |
| pmid:18680553 | p(HGNC:FYN) association p(HGNC:MAPT, frag("223_226")) |
| pmid:18680553 | p(HGNC:FYN) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) |
| pmid:26751493 | p(HGNC:FYN) association a(HBP:"projection domain") |
| pmid:19293145 | complex(p(FPLX:AKT), p(HGNC:AGAP2)) increases act(p(FPLX:AKT)) |
| pmid:19293145 | p(MGI:Fyn) decreases bp(MESH:Neuroprotection) |
| pmid:18096814 | p(MGI:Fyn) negativeCorrelation a(CHEBI:"2-bromohexadecanoic acid") |
| pmid:18096814 | p(MGI:Fyn) regulates tloc(p(MGI:Mapt), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) |
| pmid:25125464 | p(MGI:Fyn) positiveCorrelation a(GO:"neuron spine") |
| pmid:25125464 | act(p(MGI:Fyn)) increases p(MGI:Grin2b, pmod(Ph, Tyr, 1472)) |
| pmid:25125464 | act(p(MGI:Fyn)) increases p(HBP:"Tau epitope, AT8") |
| pmid:19293145 | p(HGNC:SRC) increases bp(MESH:Neuroprotection) |
| pmid:26751493 | p(HGNC:SRC) association p(HBP:"projection domain") |
| pmid:18467332 | p(HGNC:SRC) isA complex(p(HGNC:MAPT), p(HGNC:SRC)) |
| pmid:26751493 | p(HGNC:SRC) association a(HBP:"projection domain") |
| pmid:19293145 | p(HGNC:JAK2) increases bp(MESH:Neuroprotection) |
| pmid:19293145 | p(HGNC:JAK2) association bp(MESH:Neuroprotection) |
| pmid:19293145 | p(HGNC:JAK2) increases act(a(CHEBI:nicotine)) |
| pmid:19293145 | act(p(HGNC:JAK2)) regulates act(a(CHEBI:nicotine)) |
| pmid:19293145 | p(HGNC:JAK2) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | p(HGNC:JAK2) association act(p(HGNC:STAT3)) |
| pmid:19293145 | p(HGNC:JAK2) increases act(p(HGNC:FYN)) |
| pmid:19293145 | complex(p(HGNC:FYN), p(HGNC:MAPT)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:18680553 | complex(p(HGNC:FYN), p(HGNC:MAPT)) positiveCorrelation bp(GO:myelination) |
| pmid:19293145 | p(HGNC:MAPT, pmod(Ph, Tyr)) association p(HGNC:PTK2, pmod(Ph)) |
| pmid:19293145 | p(HGNC:PTK2, pmod(Ph)) association p(HGNC:MAPT, pmod(Ph, Tyr)) |
| pmid:19293145 | p(HGNC:PTK2, pmod(Ph)) decreases act(p(HGNC:PTK2)) |
| pmid:19293145 | a(CHEBI:genistein) decreases act(a(CHEBI:"amyloid-beta")) |
| pmid:19293145 | a(CHEBI:genistein) decreases act(a(CHEBI:"L-glutamate(2-)")) |
| pmid:19293145 | a(CHEBI:genistein) decreases p(HGNC:CHRNA7, pmod(Ph)) |
| pmid:17009926 | a(CHEBI:genistein) decreases p(HGNC:CHRNA7, pmod(Ph)) |
| pmid:17009926 | a(CHEBI:genistein) causesNoChange surf(p(FPLX:CHRN)) |
| pmid:17009926 | a(CHEBI:genistein) regulates p(FPLX:CHRN) |
| pmid:19293145 | p(HGNC:CHRNA7, pmod(Ph)) decreases act(a(CHEBI:acetylcholine)) |
| pmid:23038257 | p(HGNC:CHRNA7, pmod(Ph)) increases act(a(MESH:"Motor Endplate"), ma(GO:localization)) |
| pmid:17009926 | p(HGNC:CHRNA7, pmod(Ph)) decreases act(p(HGNC:CHRNA7)) |
| pmid:19293145 | a(CHEBI:estradiol) decreases act(a(CHEBI:"amyloid-beta")) |
| pmid:19293145 | a(CHEBI:estradiol) decreases path(HBP:neurotoxicity) |
| pmid:23178521 | p(HGNC:STAT3, pmod(Ph)) association a(CHEBI:nicotine) |
| pmid:19293145 | act(p(RGD:Chrna7)) regulates act(a(CHEBI:nicotine)) |
| pmid:19293145 | act(p(RGD:Chrna7)) decreases act(a(CHEBI:"glutamate(2-)")) |
| pmid:19293145 | composite(p(HGNC:JAK2), p(HGNC:STAT3)) regulates act(p(HGNC:INS)) |
| pmid:19293145 | act(p(HGNC:INS)) association path(MESH:"Alzheimer Disease") |
| pmid:19293145 | g(HGNC:NIN) association g(HGNC:GSK3B) |
| pmid:19293145 | g(HGNC:GSK3B) association g(HGNC:NIN) |
| pmid:19293145 | act(p(HGNC:MYC)) increases bp(GO:"apoptotic process") |
| pmid:19293145 | complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases bp(GO:"ERK1 and ERK2 cascade") |
| pmid:19293145 | complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases act(p(FPLX:JNK)) |
| pmid:19293145 | complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases bp(GO:"MAPK cascade") |
| pmid:19293145 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases p(HGNC:MAPK1, pmod(Ph)) |
| pmid:19293145 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases p(HGNC:MAPK3, pmod(Ph)) |
| pmid:19293145 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") causesNoChange p(HGNC:MAPK14, pmod(Ph)) |
| pmid:19293145 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") causesNoChange p(HGNC:MAPK8, pmod(Ph)) |
| pmid:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(GO:cognition) |
| pmid:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases path(MESH:"Memory, Episodic") |
| pmid:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:Neuroprotection) |
| pmid:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") decreases act(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pmid:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") decreases bp(MESH:"Cell Survival") |
| pmid:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:"Sensory Gating") |
| pmid:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:"Sensory Gating") |
| pmid:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases act(p(HGNC:CHRNA7)) |
| pmid:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(GO:memory) |
| pmid:19721446 | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases path(MESH:Attention) |
| pmid:11943212 | p(HGNC:MAPK14) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:18494933 | p(HGNC:MAPK8, pmod(Ph)) increases act(p(HGNC:MAPK8)) |
| pmid:23528736 | p(HGNC:MAPK8) increases bp(GO:autophagy) |
| pmid:23528736 | p(HGNC:MAPK8) increases p(HGNC:BCL2, pmod(Ph)) |
| pmid:23528736 | p(HGNC:MAPK8) increases p(HGNC:BCL2L11, pmod(Ph)) |
| pmid:18494933 | act(p(HGNC:MAPK8)) increases p(HGNC:JUN) |
| pmid:11943212 | p(HGNC:MAPK8) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:19293145 | a(MESH:"A-582941") increases p(HGNC:MAPK3, pmod(Ph)) |
| pmid:19293145 | a(MESH:"A-582941") increases p(HGNC:MAPK1, pmod(Ph)) |
| pmid:19293145 | a(CHEBI:"SL-327") decreases act(a(MESH:"A-582941")) |
| pmid:26118667 | p(FPLX:NFkappaB) increases complex(g(MIRBASE:"rno-mir-195"), p(FPLX:NFkappaB)) |
| pmid:19293145 | act(p(HGNC:NOS1)) increases a(CHEBI:"nitric oxide") |
| pmid:29559585 | a(CHEBI:"nitric oxide") increases p(MGI:Gapdh, pmod(NO)) |
| pmid:27601475 | a(CHEBI:"nitric oxide") positiveCorrelation a(HBP:"8-nitro-cGMP") |
| pmid:23702978 | a(CHEBI:"nitric oxide") increases p(HGNC:NLRP3, pmod(NO)) |
| pmid:27314526 | a(CHEBI:"nitric oxide") increases a(CHEBI:peroxynitrite) |
| pmid:27314526 | a(CHEBI:"nitric oxide") increases act(p(HGNC:CASP3)) |
| pmid:27314526 | a(CHEBI:"nitric oxide") increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:27314526 | a(CHEBI:"nitric oxide") increases bp(GO:"p38MAPK cascade") |
| pmid:19293145 | composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases bp(GO:"MAPK cascade") |
| pmid:19293145 | composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") |
| pmid:19293145 | composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases act(p(HGNC:MAPK1)) |
| pmid:19293145 | composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases p(FPLX:AKT, pmod(Ph)) |
| pmid:19293145 | composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases sec(a(CHEBI:dopamine)) |
| pmid:19293145 | composite(p(FPLX:ERK), p(FPLX:RAF), p(FPLX:RAS), p(HGNC:MAP2K1)) increases act(a(CHEBI:nicotine)) |
| pmid:19293145 | p(FPLX:ERK) association a(CHEBI:nicotine) |
| pmid:8282104 | p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:8282104 | p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:8282104 | p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:8282104 | p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) |
| pmid:8282104 | p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:8282104 | p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:8282104 | p(FPLX:ERK) association a(GO:microtubule) |
| pmid:8282104 | p(FPLX:ERK) association a(HBP:HBP00006) |
| pmid:8282104 | p(FPLX:ERK) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(Ph)))) |
| pmid:8282104 | p(FPLX:ERK) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27594586 | p(FPLX:ERK) regulates p(HGNC:MMP9) |
| pmid:24686445 | act(p(FPLX:ERK)) positiveCorrelation act(p(HGNC:KAT2B)) |
| pmid:19293145 | act(p(FPLX:RAS)) increases p(HGNC:STAT3) |
| pmid:18986241 | p(FPLX:RAS) association bp(GO:"GO:0014065") |
| pmid:18986241 | p(FPLX:RAS) association bp(GO:"GO:0043491") |
| pmid:19293145 | composite(p(FPLX:JAK), p(HGNC:STAT3)) increases p(HGNC:STAT3, pmod(Ph)) |
| pmid:19293145 | act(a(CHEBI:"N-methyl-D-aspartic acid")) increases path(HBP:neurotoxicity) |
| pmid:18494933 | p(FPLX:JNK) positiveCorrelation act(p(HGNC:AGER)) |
| pmid:18494933 | p(FPLX:JNK) increases p(HGNC:DKK1) |
| pmid:18494933 | act(p(FPLX:JNK)) increases p(HGNC:DKK1) |
| pmid:18494933 | act(p(FPLX:JNK)) positiveCorrelation p(FPLX:JNK, pmod(Ph)) |
| pmid:27068745 | act(p(FPLX:JNK)) positiveCorrelation p(ECCODE:"1.6.3.1") |
| pmid:27068745 | act(p(FPLX:JNK)) association p(HGNC:CASP3) |
| pmid:19293145 | bp(GO:"calcium-mediated signaling") association act(a(CHEBI:"amyloid-beta")) |
| pmid:19293145 | bp(GO:"calcium-mediated signaling") association bp(MESH:Neuroprotection) |
| pmid:19293145 | bp(GO:"calcium-mediated signaling") association act(p(HGNC:CHRNA7)) |
| pmid:19293145 | bp(GO:"calcium-mediated signaling") association a(CHEBI:nicotine) |
| pmid:19293145 | bp(GO:"calcium-mediated signaling") association composite(p(HGNC:JAK2), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:25514383 | bp(GO:"calcium ion transport") negativeCorrelation a(HBP:"alpha-4 beta-2 nAChR") |
| pmid:25514383 | bp(GO:"calcium ion transport") positiveCorrelation a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:21482353 | bp(GO:"calcium ion transport") association act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:19293145 | a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole") increases act(p(RGD:Chrna7)) |
| pmid:19721446 | a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole") association path(MESH:"Attention Deficit Disorder with Hyperactivity") |
| pmid:19293145 | a(CHEBI:"calcium(1+)") decreases act(a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole")) |
| pmid:19293145 | p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors") association a(CHEBI:nicotine) |
| pmid:19293145 | act(p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors")) association a(CHEBI:"calcium(2+)") |
| pmid:19293145 | p(HGNCGENEFAMILY:"Ryanodine receptors") association a(CHEBI:nicotine) |
| pmid:19293145 | act(p(HGNCGENEFAMILY:"Ryanodine receptors")) increases bp(GO:"cellular calcium ion homeostasis") |
| pmid:19293145 | a(MESH:Calcineurin) association act(a(CHEBI:nicotine)) |
| pmid:19293145 | a(MESH:Calcineurin) association bp(MESH:Neuroprotection) |
| pmid:19293145 | composite(a(CHEBI:"calcium(2+)"), a(MESH:Calcineurin), p(HGNC:PTPN5)) increases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits", pmod(Ph)) |
| pmid:19293145 | bp(GO:"regulation of cytosolic calcium ion concentration") association path(MESH:"Alzheimer Disease") |
| pmid:19293145 | composite(a(CHEBI:"amyloid-beta"), complex(p(HGNC:CHRNA3), p(HGNC:CHRNB2))) increases bp(GO:"cellular calcium ion homeostasis") |
| pmid:19293145 | composite(p(HGNC:JAK2), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association bp(GO:"calcium-mediated signaling") |
| pmid:19293145 | composite(p(HGNC:MAPK14), p(HGNC:MAPK8)) decreases bp(GO:"long-term synaptic potentiation") |
| pmid:19293145 | g(HGNC:APOE) increases p(HGNC:APOE) |
| pmid:19293145 | g(HGNC:APOE) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | g(HGNC:APOE) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | g(HGNC:APOE) negativeCorrelation p(HGNC:CHAT) |
| pmid:19293145 | g(HGNC:APOE) negativeCorrelation act(a(CHEBI:tacrine)) |
| pmid:19293145 | g(HGNC:APOE) causesNoChange complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| pmid:19293145 | p(HGNC:APOE) association bp(GO:"lipid metabolic process") |
| pmid:19293145 | p(HGNC:APOE) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:21718217 | p(HGNC:APOE) increases a(CHEBI:"high-density lipoprotein") |
| pmid:21718217 | p(HGNC:APOE) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:21718217 | act(p(HGNC:APOE)) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:26195256 | p(HGNC:APOE) regulates a(CHEBI:"amyloid-beta") |
| pmid:26195256 | p(HGNC:APOE) decreases act(a(CHEBI:"amyloid-beta")) |
| pmid:26195256 | p(HGNC:APOE) regulates a(CHEBI:"amyloid-beta") |
| pmid:19293145 | bp(GO:"lipid metabolic process") association p(HGNC:APOE) |
| pmid:19293145 | bp(GO:"lipid metabolic process") association p(HGNC:CHRNA4) |
| pmid:19293145 | p(HGNC:CHRNA7, var("p.Trp55Ala")) decreases complex(p(HGNC:APOE), p(HGNC:CHRNA7)) |
| pmid:19293145 | act(a(CHEBI:carbachol)) decreases a(CHEBI:phosphatidylinositol) |
| pmid:24590577 | a(CHEBI:carbachol) increases act(p(HGNC:CHRM1)) |
| pmid:26751493 | a(CHEBI:phosphatidylinositol) association p(HBP:"projection domain") |
| pmid:26751493 | a(CHEBI:phosphatidylinositol) association a(HBP:"projection domain") |
| pmid:19293145 | p(HBP:"APOE e4") decreases act(a(CHEBI:carbachol), ma(MESH:Hydrolysis)) |
| pmid:26195256 | p(HBP:"APOE e4") association path(MESH:"Alzheimer Disease") |
| pmid:26195256 | p(HBP:"APOE e4") regulates a(MESH:"Blood-Brain Barrier") |
| pmid:26195256 | p(HBP:"APOE e4") decreases bp(HBP:"perivascular drainage pathways") |
| pmid:27087442 | p(HBP:"APOE e4") increases p(MGI:Cdk5) |
| pmid:27087442 | p(HBP:"APOE e4") increases p(HBP:"CDK5R1 p25") |
| pmid:27087442 | p(HBP:"APOE e4") increases p(MGI:Cdk5r1) |
| pmid:27087442 | p(HBP:"APOE e4") increases p(MGI:Capn1) |
| pmid:27087442 | p(HBP:"APOE e4") increases p(MGI:Capn2) |
| pmid:27087442 | p(HBP:"APOE e4") causesNoChange p(MGI:Gsk3b) |
| pmid:28720530 | p(HBP:"APOE e4") directlyDecreases p(HGNC:PPP2R5E) |
| pmid:28720530 | p(HBP:"APOE e4") negativeCorrelation complex(GO:"protein phosphatase type 2A complex") |
| pmid:19293145 | a(CHEBI:wortmannin) decreases act(a(CHEBI:estrogen)) |
| pmid:19293145 | composite(a(CHEBI:nicotine), complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) decreases sec(a(CHEBI:"amyloid-beta")) |
| pmid:19293145 | composite(a(CHEBI:nicotine), complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) causesNoChange r(HGNC:APP) |
| pmid:22040696 | complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7)) |
| pmid:19293145 | complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases path(HBP:neurotoxicity) |
| pmid:19293145 | complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) decreases complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) |
| pmid:18986241 | complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases r(HGNC:CHRNA7) |
| pmid:18986241 | complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) decreases bp(GO:"GO:0007271") |
| pmid:22040696 | complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases bp(GO:"neuron death") |
| pmid:19293145 | composite(p(HGNC:MAPK1), p(HGNC:MAPK3)) association bp(GO:memory) |
| pmid:19293145 | composite(p(FPLX:ERK), p(HGNC:CHRNA7)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:19293145 | composite(p(FPLX:JNK), p(HGNC:CHRNA7)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:19293145 | complex(p(FPLX:AKT), p(HGNC:BAD)) regulates bp(GO:"apoptotic process") |
| pmid:19293145 | bp(GO:"insulin receptor signaling pathway") association p(FPLX:AKT) |
| pmid:19293145 | bp(GO:"choline transport") association a(CHEBI:"amyloid-beta") |
| pmid:19293145 | complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) |
| pmid:19293145 | complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) |
| pmid:19293145 | complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:methyllycaconitine), p(HGNC:CHRNA7)) |
| pmid:25514383 | a(CHEBI:methyllycaconitine) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:25514383 | a(CHEBI:methyllycaconitine) decreases bp(HP:Neurodegeneration) |
| pmid:19293145 | p(HGNC:APP, frag("25_35")) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19293145 | p(HGNC:APP, frag("25_35")) increases act(p(HGNC:CHRNA7)) |
| pmid:19721446 | complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2)) association a(MESH:"Dopaminergic Neurons") |
| pmid:21482353 | p(HGNC:CHRNA7, var("?")) positiveCorrelation path(MESH:Schizophrenia) |
| pmid:19293145 | a(MESH:"Cholinergic Neurons") increases act(p(HGNC:CHAT)) |
| pmid:26813123 | act(a(MESH:"Cholinergic Neurons")) increases path(MESH:Attention) |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") increases path(MESH:Attention) |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") positiveCorrelation bp(GO:memory) |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") increases bp(GO:memory) |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") increases bp(GO:"circadian sleep/wake cycle, REM sleep") |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") increases a(CHEBI:acetylcholine) |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") increases a(CHEBI:choline) |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") increases tloc(p(HGNC:ACHE), fromLoc(MESH:"Synaptic Vesicles"), toLoc(GO:"synaptic cleft")) |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") increases bp(GO:"synaptic transmission, dopaminergic") |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") decreases path(MESH:Apathy) |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") decreases path(MESH:Depression) |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Parkinson Disease") |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Down Syndrome") |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Olivopontocerebellar Atrophies") |
| pmid:26813123 | a(MESH:"Cholinergic Neurons") association act(p(HGNC:CHRM1)) |
| pmid:28901280 | a(MESH:"Cholinergic Neurons") increases a(MESH:Acetylcholine) |
| pmid:18986241 | r(HGNC:CHRNA7) negativeCorrelation path(MESH:D003071) |
| pmid:18986241 | r(HGNC:CHRNA7) regulates act(a(MESH:D059329)) |
| pmid:18986241 | r(HGNC:CHRNA7) increases path(MESH:D009410) |
| pmid:11230871 | r(HGNC:CHRNA7) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19293145 | composite(a(CHEBI:"amyloid-beta"), p(MGI:Ache)) increases r(MGI:Chrna7) |
| pmid:19293145 | composite(a(CHEBI:"amyloid-beta"), p(MGI:Ache)) causesNoChange r(MGI:Chrna4) |
| pmid:23038257 | a(CHEBI:"4-(trimethylammonium)benzenediazonium") decreases act(a(MESH:"Electric Organ")) |
| pmid:23038257 | a(MESH:Curare) decreases act(a(CHEBI:"4-(trimethylammonium)benzenediazonium")) |
| pmid:23038257 | a(CHEBI:"4-(N-Maleimido)phenyltrimethylammonium iodide") increases act(a(MESH:"Affinity Labels")) |
| pmid:23038257 | a(CHEBI:decamethonium) decreases act(a(MESH:"Receptors, Nicotinic")) |
| pmid:26813123 | a(MESH:"Receptors, Nicotinic") increases act(a(MESH:"Hypothalamo-Hypophyseal System")) |
| pmid:26813123 | act(a(MESH:"Receptors, Nicotinic")) increases bp(MESH:"Synaptic Transmission") |
| pmid:26813123 | a(MESH:"Receptors, Nicotinic") regulates tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:26813123 | act(a(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular region"), toLoc(GO:synapse)) |
| pmid:26813123 | act(a(MESH:"Receptors, Nicotinic")) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:19721446 | a(MESH:"Receptors, Nicotinic") regulates sec(a(CHEBI:serotonin)) |
| pmid:23038257 | a(MESH:"Gallamine Triethiodide") decreases act(a(MESH:"Receptors, Nicotinic")) |
| pmid:23038257 | a(CHEBI:chlorpromazine) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) |
| pmid:23038257 | a(CHEBI:chlorpromazine) association p(HGNC:SCNN1D) |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") isA p(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors") |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:Learning) |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:Memory) |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:Arousal) |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:Reward) |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association bp(MESH:Analgesia) |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association bp(GO:"action potential initiation") |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association bp(HBP:"cell population proliferation") |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association bp(GO:"cell differentiation") |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:"Cognition Disorders") |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:Anxiety) |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:Depression) |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:"Alzheimer Disease") |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:"Parkinson Disease") |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:Pain) |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association path(MESH:Epilepsy) |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic") association a(MESH:Neurons) |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic", loc(MESH:"GABAergic Neurons")) association a(HBP:neurotransmitters) |
| pmid:28901280 | p(MESH:"Receptors, Nicotinic", loc(MESH:"Cholinergic Neurons")) association a(HBP:neurotransmitters) |
| pmid:23038257 | p(HGNC:SCNN1D) association a(CHEBI:chlorpromazine) |
| pmid:23038257 | a(CHEBI:"zinc(2+)") increases act(p(MESH:"Receptors, Nicotinic")) |
| pmid:19721446 | a(CHEBI:"zinc(2+)") decreases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:2833519 | a(CHEBI:"zinc(2+)") increases act(p(HGNC:S100B)) |
| pmid:23038257 | a(MESH:Galantamine) regulates act(p(MESH:"Receptors, Nicotinic")) |
| pmid:23038257 | a(MESH:Ivermectin) increases act(p(HGNC:CHRNA7)) |
| pmid:23038257 | p(HGNC:SCNN1D, var("?")) regulates act(a(MESH:Ivermectin)) |
| pmid:23038257 | a(MESH:Anesthetics) decreases p(MESH:"Receptors, Nicotinic") |
| pmid:23038257 | a(MESH:Anesthetics) increases p(MESH:"Receptors, GABA") |
| pmid:19721446 | a(MESH:Anesthetics) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:23038257 | p(MESH:Agrin) increases p(HGNC:RAPSN, pmod(Ph, Tyr)) |
| pmid:23038257 | p(HGNC:RAPSN, pmod(Ph, Tyr)) increases act(a(MESH:"Motor Endplate"), ma(GO:localization)) |
| pmid:22040696 | p(HGNC:RAPSN) increases bp(GO:"skeletal muscle acetylcholine-gated channel clustering") |
| pmid:23038257 | p(MESH:"Receptors, Nicotinic", pmod(Ph)) increases act(p(MESH:Agrin)) |
| pmid:23038257 | p(MESH:"Cytoskeletal Proteins") association p(HGNC:CHRNA4) |
| pmid:24511233 | path(MESH:"Psychotic Disorders") association path(MESH:"Alzheimer Disease") |
| pmid:24511233 | path(MESH:"Psychotic Disorders") association path(MESH:"Alzheimer Disease") |
| pmid:24511233 | path(MESH:"Psychotic Disorders") association path(MESH:"Alzheimer Disease") |
| pmid:24511233 | path(MESH:"Psychotic Disorders") association path(MESH:Schizophrenia) |
| pmid:24590577 | path(MESH:"Psychotic Disorders") association p(HGNC:CHRM4) |
| pmid:22040696 | path(MESH:"Psychotic Disorders") negativeCorrelation act(p(HGNC:RIC3), ma(chap)) |
| pmid:24511233 | path(MESH:Hallucinations) association path(MESH:Schizophrenia) |
| pmid:24511233 | path(MESH:Hallucinations) biomarkerFor path(MESH:Schizophrenia) |
| pmid:19721446 | path(MESH:Hallucinations) association path(MESH:Schizophrenia) |
| pmid:24511233 | path(MESH:Delusions) association path(MESH:Schizophrenia) |
| pmid:24511233 | path(MESH:Delusions) biomarkerFor path(MESH:Schizophrenia) |
| pmid:19721446 | path(MESH:Delusions) association path(MESH:Schizophrenia) |
| pmid:24511233 | bp(GO:behavior) association path(MESH:Schizophrenia) |
| pmid:24511233 | bp(GO:behavior) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:28420982 | bp(GO:behavior) association p(HGNC:MAPT) |
| pmid:24511233 | p(HGNC:CHRM1) association bp(GO:cognition) |
| pmid:24511233 | act(p(HGNC:CHRM1)) increases bp(GO:cognition) |
| pmid:24590577 | act(p(HGNC:CHRM1)) increases bp(GO:cognition) |
| pmid:24511233 | p(HGNC:CHRM1) decreases act(a(CHEBI:amphetamine)) |
| pmid:24511233 | p(HGNC:CHRM1) decreases bp(GO:"dopamine secretion, neurotransmission") |
| pmid:24511233 | p(HGNC:CHRM1) increases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pmid:24511233 | act(p(HGNC:CHRM1)) increases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) |
| pmid:24511233 | p(HGNC:CHRM1) increases bp(GO:"long-term synaptic potentiation") |
| pmid:24511233 | act(p(HGNC:CHRM1)) increases a(CHEBI:acetylcholine) |
| pmid:24511233 | act(p(HGNC:CHRM1)) increases deg(a(HBP:"sAPP-alpha")) |
| pmid:24590577 | act(p(HGNC:CHRM1)) increases a(HBP:"sAPP-alpha") |
| pmid:26813123 | act(p(HGNC:CHRM1)) association a(MESH:"Cholinergic Neurons") |
| pmid:26813123 | act(p(HGNC:CHRM1)) association path(MESH:"Cognitive Dysfunction") |
| pmid:26813123 | act(p(HGNC:CHRM1)) association act(p(HGNC:MAPT)) |
| pmid:26813123 | act(p(HGNC:CHRM1)) association act(a(CHEBI:"amyloid-beta")) |
| pmid:24590577 | act(p(HGNC:CHRM1)) decreases a(CHEBI:"amyloid-beta") |
| pmid:26813123 | act(p(HGNC:CHRM1)) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:26813123 | act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) |
| pmid:24590577 | act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) |
| pmid:24590577 | act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) |
| pmid:24590577 | act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) |
| pmid:26813123 | act(p(HGNC:CHRM1)) decreases act(p(HGNC:GSK3B)) |
| pmid:24590577 | act(p(HGNC:CHRM1)) decreases act(p(HGNC:GSK3B)) |
| pmid:24590577 | p(HGNC:CHRM1) association a(MESH:Hippocampus) |
| pmid:24590577 | p(HGNC:CHRM1) association a(MESH:"Cerebral Cortex") |
| pmid:24590577 | p(HGNC:CHRM1) association a(MESH:"Corpus Striatum") |
| pmid:24590577 | p(HGNC:CHRM1) association a(MESH:Thalamus) |
| pmid:24590577 | p(HGNC:CHRM1) association bp(GO:"regulation of synaptic plasticity") |
| pmid:24590577 | p(HGNC:CHRM1) association bp(GO:learning) |
| pmid:24590577 | p(HGNC:CHRM1) association bp(GO:memory) |
| pmid:24590577 | p(HGNC:CHRM1) association bp(GO:"neuronal signal transduction") |
| pmid:24590577 | p(HGNC:CHRM1) association bp(GO:"neuron differentiation") |
| pmid:24590577 | p(HGNC:CHRM1) regulates bp(GO:"synaptic transmission, glutamatergic") |
| pmid:24590577 | act(p(HGNC:CHRM1)) increases bp(GO:"ERK1 and ERK2 cascade") |
| pmid:24590577 | act(p(HGNC:CHRM1)) causesNoChange bp(GO:"ERK1 and ERK2 cascade") |
| pmid:24590577 | act(p(HGNC:CHRM1)) increases p(HGNC:BACE1) |
| pmid:24590577 | p(HGNC:CHRM1) regulates p(HGNC:BACE1) |
| pmid:24590577 | act(p(HGNC:CHRM1)) increases bp(GO:"MAPK cascade") |
| pmid:24590577 | act(p(HGNC:CHRM1)) increases bp(HBP:neurotoxicity) |
| pmid:24590577 | act(p(HGNC:CHRM1)) increases bp(GO:"Wnt signaling pathway") |
| pmid:24590577 | act(p(HGNC:CHRM1)) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24590577 | act(p(HGNC:CHRM1)) decreases path(MESH:"DNA Damage") |
| pmid:24590577 | act(p(HGNC:CHRM1)) decreases path(MESH:"Oxidative Stress") |
| pmid:24590577 | act(p(HGNC:CHRM1)) decreases act(p(HGNCGENEFAMILY:Caspases)) |
| pmid:24590577 | act(p(HGNC:CHRM1)) decreases bp(GO:"cell death") |
| pmid:18986241 | p(HGNC:CHRM1) association path(MESH:D060825) |
| pmid:18986241 | p(HGNC:CHRM1) association path(MESH:D024801) |
| pmid:18986241 | p(HGNC:CHRM1) association path(MESH:D000686) |
| pmid:26813123 | p(HGNC:CHRM2) decreases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:26813123 | act(p(HGNC:CHRM2)) increases a(CHEBI:"amyloid-beta") |
| pmid:24590577 | p(HGNC:CHRM2) association a(MESH:Hippocampus) |
| pmid:24590577 | p(HGNC:CHRM2) association a(MESH:Neocortex) |
| pmid:24590577 | p(HGNC:CHRM2) decreases act(a(CHEBI:dopamine)) |
| pmid:24590577 | p(HGNC:CHRM3) association a(MESH:Hypothalamus) |
| pmid:24590577 | p(HGNC:CHRM3) association a(MESH:Hippocampus) |
| pmid:24511233 | p(HGNC:CHRM4) association path(MESH:"Avoidance Learning") |
| pmid:24511233 | p(HGNC:CHRM4) association a(MESH:Hippocampus) |
| pmid:24511233 | p(HGNC:CHRM4) association a(MESH:"Corpus Striatum") |
| pmid:24590577 | p(HGNC:CHRM4) association a(MESH:"Corpus Striatum") |
| pmid:24511233 | p(HGNC:CHRM4) association a(MESH:Neocortex) |
| pmid:24511233 | p(HGNC:CHRM4) regulates bp(GO:"synaptic transmission, dopaminergic") |
| pmid:24511233 | act(p(HGNC:CHRM4)) decreases bp(GO:"synaptic transmission, glutamatergic") |
| pmid:24590577 | p(HGNC:CHRM4) association path(MESH:"Psychotic Disorders") |
| pmid:24590577 | p(HGNC:CHRM4) association path(MESH:"Parkinson Disease") |
| pmid:24590577 | p(HGNC:CHRM4) decreases act(p(HGNC:DRD1)) |
| pmid:24590577 | p(HGNC:CHRM5) association a(MESH:"Pars Compacta") |
| pmid:24590577 | p(HGNC:CHRM5) increases bp(GO:"response to drug") |
| pmid:24590577 | p(HGNC:CHRM5) increases act(a(CHEBI:morphine)) |
| pmid:24590577 | p(HGNC:CHRM5) increases act(a(CHEBI:cocaine)) |
| pmid:24511233 | complex(p(HGNC:CHRM1), p(HGNC:GNAQ)) increases bp(GO:"calcium ion transport") |
| pmid:24511233 | complex(p(HGNC:CHRM1), p(HGNC:GNAQ)) increases a(MESH:"Inositol 1,4,5-Trisphosphate") |
| pmid:26088141 | p(HGNC:GNAQ) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ)) |
| pmid:24511233 | complex(p(HGNC:CHRM3), p(HGNC:GNAQ)) increases bp(GO:"calcium ion transport") |
| pmid:24511233 | complex(p(HGNC:CHRM3), p(HGNC:GNAQ)) increases a(MESH:"Inositol 1,4,5-Trisphosphate") |
| pmid:24511233 | complex(p(HGNC:CHRM5), p(HGNC:GNAQ)) increases bp(GO:"calcium ion transport") |
| pmid:24511233 | complex(p(HGNC:CHRM5), p(HGNC:GNAQ)) increases a(MESH:"Inositol 1,4,5-Trisphosphate") |
| pmid:24511233 | complex(p(HGNC:CHRM2), p(HGNC:GNAI1)) decreases a(CHEBI:"3',5'-cyclic AMP") |
| pmid:26088141 | p(HGNC:GNAI1) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAI1)) |
| pmid:24511233 | complex(p(HGNC:CHRM4), p(HGNC:GNAI1)) decreases a(CHEBI:"3',5'-cyclic AMP") |
| pmid:17009926 | path(MESH:Depression) association p(FPLX:CHRN) |
| pmid:11230871 | path(MESH:Depression) association p(FPLX:CHRN) |
| pmid:26813123 | path(MESH:Depression) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21482353 | path(MESH:Depression) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:19721446 | path(MESH:Depression) increases a(CHEBI:choline) |
| pmid:28901280 | path(MESH:Depression) association p(MESH:"Receptors, Nicotinic") |
| pmid:27314526 | bp(HBP:neuroinflammation) association sec(a(MESH:Interleukins)) |
| pmid:24511233 | a(MESH:"Cerebral Cortex") association bp(GO:cognition) |
| pmid:24511233 | a(MESH:"Cerebral Cortex") association bp(GO:learning) |
| pmid:24511233 | a(MESH:"Cerebral Cortex") association bp(GO:learning) |
| pmid:24511233 | a(MESH:"Cerebral Cortex") association bp(GO:memory) |
| pmid:24511233 | a(MESH:"Cerebral Cortex") association bp(GO:memory) |
| pmid:24590577 | a(MESH:"Cerebral Cortex") association p(HGNC:CHRM1) |
| pmid:26195256 | a(MESH:"Cerebral Cortex") association path(MESH:"Alzheimer Disease") |
| pmid:24511233 | a(MESH:"Muscarinic Antagonists") decreases bp(GO:cognition) |
| pmid:24511233 | a(MESH:"Muscarinic Antagonists") increases path(MESH:"Cognitive Dysfunction") |
| pmid:24511233 | a(MESH:"Muscarinic Antagonists") association path(MESH:"Mental Processes") |
| pmid:24511233 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases bp(GO:"synaptic transmission, cholinergic") |
| pmid:24511233 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases bp(GO:cognition) |
| pmid:24511233 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases path(MESH:"Mental Processes") |
| pmid:24511233 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") association a(MESH:"Cardiovascular System") |
| pmid:24511233 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") association a(MESH:"Gastrointestinal Tract") |
| pmid:17009926 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") decreases path(MESH:"Alzheimer Disease") |
| pmid:17009926 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") decreases act(p(HGNC:ACHE)) |
| pmid:17009926 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") decreases rxn(reactants(a(CHEBI:acetylcholine)), products(a(CHEBI:acetate), a(CHEBI:choline))) |
| pmid:17009926 | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases act(p(FPLX:CHRN)) |
| pmid:24511233 | path(MESH:"Mental Processes") association a(MESH:"Muscarinic Antagonists") |
| pmid:24511233 | a(MESH:"Cardiovascular System") association a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") |
| pmid:24590577 | a(MESH:"Cardiovascular System") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pmid:24511233 | a(MESH:"Gastrointestinal Tract") association a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") |
| pmid:24511233 | a(MESH:"Gastrointestinal Tract") association a(CHEBI:xanomeline) |
| pmid:24590577 | a(MESH:"Gastrointestinal Tract") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pmid:29626319 | a(MESH:"Gastrointestinal Tract") decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(MESH:"Gastrointestinal Tract") decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:29626319 | a(MESH:"Gastrointestinal Tract") causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:24511233 | path(MESH:Anhedonia) biomarkerFor path(MESH:Schizophrenia) |
| pmid:24511233 | path(MESH:"Social Isolation") biomarkerFor path(MESH:Schizophrenia) |
| pmid:24511233 | path(MESH:"Memory, Short-Term") association path(MESH:Schizophrenia) |
| pmid:24511233 | path(MESH:Attention) association path(MESH:Schizophrenia) |
| pmid:17009926 | path(MESH:Attention) association p(FPLX:CHRN) |
| pmid:26813123 | path(MESH:Attention) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:24590577 | path(MESH:Attention) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pmid:25514383 | path(MESH:Attention) association a(HP:"cholinergic neuron") |
| pmid:24511233 | path(MESH:"Executive Function") association path(MESH:Schizophrenia) |
| pmid:24511233 | a(CHEBI:"antipsychotic agent") regulates p(HGNC:DRD2) |
| pmid:24511233 | a(CHEBI:"antipsychotic agent") causesNoChange bp(GO:cognition) |
| pmid:24511233 | bp(GO:"synaptic transmission, glutamatergic") association path(MESH:Schizophrenia) |
| pmid:26813123 | bp(GO:"synaptic transmission, glutamatergic") association bp(GO:cognition) |
| pmid:26813123 | bp(GO:"synaptic transmission, glutamatergic") association bp(HBP:Neurodegeneration) |
| pmid:24511233 | bp(GO:"gamma-aminobutyric acid signaling pathway") association path(MESH:Schizophrenia) |
| pmid:24511233 | a(CHEBI:xanomeline) increases bp(GO:cognition) |
| pmid:26813123 | a(CHEBI:xanomeline) increases bp(GO:cognition) |
| pmid:24590577 | a(CHEBI:xanomeline) increases bp(GO:cognition) |
| pmid:24511233 | a(CHEBI:xanomeline) decreases path(MESH:Hallucinations) |
| pmid:26813123 | a(CHEBI:xanomeline) decreases path(MESH:Hallucinations) |
| pmid:24511233 | a(CHEBI:xanomeline) decreases path(MESH:Delusions) |
| pmid:24511233 | a(CHEBI:xanomeline) decreases path(MESH:Schizophrenia) |
| pmid:24511233 | a(CHEBI:xanomeline) increases bp(GO:learning) |
| pmid:24511233 | a(CHEBI:xanomeline) increases path(MESH:"Memory, Short-Term") |
| pmid:24511233 | a(CHEBI:xanomeline) association a(MESH:"Gastrointestinal Tract") |
| pmid:26813123 | a(CHEBI:xanomeline) increases bp(GO:memory) |
| pmid:24590577 | a(CHEBI:xanomeline) increases bp(GO:memory) |
| pmid:26813123 | a(CHEBI:xanomeline) decreases path(MESH:"Mood Disorders") |
| pmid:26813123 | a(CHEBI:xanomeline) decreases path(MESH:"Psychomotor Agitation") |
| pmid:24590577 | a(CHEBI:xanomeline) decreases path(MESH:"Psychotic Disorders") |
| pmid:24590577 | a(CHEBI:xanomeline) increases act(p(HGNC:CHRM1)) |
| pmid:24590577 | a(CHEBI:xanomeline) increases act(p(HGNC:CHRM4)) |
| pmid:24511233 | act(a(CHEBI:amphetamine)) increases bp(GO:locomotion) |
| pmid:24511233 | p(MGI:Chrm1) decreases act(a(CHEBI:"amyloid-beta")) |
| pmid:24590577 | p(MGI:Chrm1) increases bp(GO:cognition) |
| pmid:24590577 | p(MGI:Chrm1) increases bp(GO:"long-term synaptic potentiation") |
| pmid:24590577 | act(p(MGI:Chrm1)) decreases bp(HBP:"APP processing") |
| pmid:24590577 | act(p(MGI:Chrm1)) decreases path(MESH:"Plaque, Amyloid") |
| pmid:18986241 | act(p(MGI:Chrm1)) increases act(p(MGI:Adam17)) |
| pmid:24511233 | a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") increases act(p(HGNC:CHRM1)) |
| pmid:24590577 | a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") increases bp(GO:cognition) |
| pmid:24590577 | a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") association a(MESH:"Antipsychotic Agents") |
| pmid:24511233 | a(MESH:"1-(3-(4-butyl-1-piperidinyl)propyl)-3,4-dihydro-2(1H)-quinolinone") increases act(p(HGNC:CHRM1)) |
| pmid:24590577 | a(MESH:"1-(3-(4-butyl-1-piperidinyl)propyl)-3,4-dihydro-2(1H)-quinolinone") increases act(p(HGNC:CHRM1)) |
| pmid:24590577 | a(MESH:"1-(3-(4-butyl-1-piperidinyl)propyl)-3,4-dihydro-2(1H)-quinolinone") increases act(a(MESH:"Pyramidal Cells")) |
| pmid:24511233 | a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") increases act(p(HGNC:CHRM1)) |
| pmid:24590577 | a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") increases act(p(HGNC:CHRM1)) |
| pmid:24511233 | a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") decreases act(a(CHEBI:scopolamine)) |
| pmid:24511233 | a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") decreases a(CHEBI:"amyloid-beta") |
| pmid:24590577 | a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") decreases a(CHEBI:"amyloid-beta") |
| pmid:24590577 | a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") increases bp(GO:"NMDA selective glutamate receptor signaling pathway") |
| pmid:24511233 | act(a(CHEBI:scopolamine)) decreases bp(GO:"behavioral fear response") |
| pmid:24511233 | a(MESH:VU0357017) increases complex(a(MESH:VU0357017), p(HGNC:CHRM1)) |
| pmid:24511233 | a(MESH:VU0357017) decreases act(a(CHEBI:scopolamine)) |
| pmid:24511233 | a(MESH:VU0357017) increases bp(GO:"behavioral fear response") |
| pmid:24590577 | a(MESH:VU0357017) increases act(p(HGNC:CHRM1)) |
| pmid:24590577 | a(MESH:VU0357017) decreases path(MESH:"Cognitive Dysfunction") |
| pmid:24590577 | a(MESH:VU0357017) increases bp(GO:learning) |
| pmid:24511233 | complex(a(MESH:VU0357017), p(HGNC:CHRM1)) increases act(p(HGNC:CHRM1)) |
| pmid:24511233 | complex(a(MESH:"GSK 1034702"), p(HGNC:CHRM1)) increases bp(GO:cognition) |
| pmid:24511233 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases act(p(HGNC:CHRM1)) |
| pmid:24511233 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:"excitatory postsynaptic potential") |
| pmid:24511233 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") decreases act(a(CHEBI:scopolamine)) |
| pmid:24511233 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:"behavioral fear response") |
| pmid:24511233 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:learning) |
| pmid:24590577 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:learning) |
| pmid:24511233 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:memory) |
| pmid:24590577 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1)) |
| pmid:24590577 | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") regulates bp(HBP:"APP processing") |
| pmid:24511233 | a(MESH:"Prefrontal Cortex") association bp(GO:cognition) |
| pmid:24511233 | a(MESH:"Prefrontal Cortex") association bp(GO:learning) |
| pmid:24511233 | a(MESH:"Prefrontal Cortex") association bp(GO:memory) |
| pmid:26195256 | a(MESH:"Prefrontal Cortex") association path(MESH:"Alzheimer Disease") |
| pmid:24511233 | a(MESH:"VU 0405652") increases act(p(HGNC:CHRM1)) |
| pmid:24511233 | a(HBP:VU0456940) increases act(p(HGNC:CHRM1)) |
| pmid:24511233 | a(MESH:"6-(4-butylthio-1,2,5-thiadiazol-3-yl)-1-azabicyclo(3.2.1)octane") decreases act(a(CHEBI:apomorphine)) |
| pmid:24511233 | a(MESH:"6-(4-butylthio-1,2,5-thiadiazol-3-yl)-1-azabicyclo(3.2.1)octane") decreases path(MESH:"Avoidance Learning") |
| pmid:24511233 | act(a(CHEBI:apomorphine)) decreases bp(GO:"prepulse inhibition") |
| pmid:24511233 | act(a(CHEBI:apomorphine)) decreases bp(GO:"prepulse inhibition") |
| pmid:24511233 | path(MESH:"Avoidance Learning") association p(HGNC:CHRM4) |
| pmid:24511233 | a(MESH:"Corpus Striatum") association p(HGNC:CHRM4) |
| pmid:24590577 | a(MESH:"Corpus Striatum") association p(HGNC:CHRM4) |
| pmid:24590577 | a(MESH:"Corpus Striatum") association p(HGNC:CHRM1) |
| pmid:24762290 | a(MESH:"Corpus Striatum") association complex(HBP:"alpha-4 beta-2 nAChR") |
| pmid:24511233 | a(MESH:Neocortex) association p(HGNC:CHRM4) |
| pmid:24590577 | a(MESH:Neocortex) association p(HGNC:CHRM2) |
| pmid:24511233 | a(HBP:VU10010) increases act(a(CHEBI:acetylcholine)) |
| pmid:24511233 | a(HBP:VU10010) increases act(p(HGNC:CHRM4)) |
| pmid:24511233 | a(HBP:VU0152099) decreases act(a(CHEBI:amphetamine)) |
| pmid:24511233 | a(MESH:"3-amino-5-chloro-6-methoxy-4-methyl-thieno(2,3-b)pyridine-2-carboxylic acid cyclopropylamide") decreases act(a(CHEBI:amphetamine)) |
| pmid:17009926 | p(FPLX:CHRN) increases bp(GO:"neurotransmitter secretion") |
| pmid:17009926 | act(p(FPLX:CHRN)) increases bp(GO:"neurotransmitter secretion") |
| pmid:17009926 | p(FPLX:CHRN) increases bp(GO:"neurotransmitter secretion") |
| pmid:17009926 | p(FPLX:CHRN) regulates bp(GO:"rhythmic excitation") |
| pmid:17009926 | p(FPLX:CHRN) regulates bp(GO:"rhythmic excitation") |
| pmid:17009926 | p(FPLX:CHRN) regulates bp(GO:"neuron remodeling") |
| pmid:17009926 | p(FPLX:CHRN) association bp(GO:"regulation of synaptic plasticity") |
| pmid:17009926 | act(p(FPLX:CHRN)) increases bp(GO:"regulation of synaptic plasticity") |
| pmid:17009926 | p(FPLX:CHRN) association bp(GO:"regulation of synaptic plasticity") |
| pmid:17009926 | p(FPLX:CHRN) association path(MESH:Attention) |
| pmid:17009926 | p(FPLX:CHRN) association bp(GO:learning) |
| pmid:17009926 | p(FPLX:CHRN) association bp(GO:memory) |
| pmid:11230871 | p(FPLX:CHRN) association bp(GO:memory) |
| pmid:17009926 | p(FPLX:CHRN) association bp(GO:"developmental process") |
| pmid:17009926 | p(FPLX:CHRN) association path(MESH:Schizophrenia) |
| pmid:17009926 | p(FPLX:CHRN) association path(MESH:Schizophrenia) |
| pmid:21482353 | act(p(FPLX:CHRN)) association path(MESH:Schizophrenia) |
| pmid:11230871 | p(FPLX:CHRN) association path(MESH:Schizophrenia) |
| pmid:17009926 | p(FPLX:CHRN) association path(MESH:Epilepsy) |
| pmid:17009926 | p(FPLX:CHRN) association path(MESH:Epilepsy) |
| pmid:11230871 | p(FPLX:CHRN) association path(MESH:Epilepsy) |
| pmid:17009926 | p(FPLX:CHRN) association path(MESH:"Autistic Disorder") |
| pmid:17009926 | act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Autistic Disorder") |
| pmid:17009926 | p(FPLX:CHRN) negativeCorrelation path(MESH:"Autistic Disorder") |
| pmid:17009926 | p(FPLX:CHRN) association path(MESH:"Alzheimer Disease") |
| pmid:17009926 | act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:17009926 | p(FPLX:CHRN) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:17009926 | p(FPLX:CHRN) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:11230871 | p(FPLX:CHRN) association path(MESH:"Alzheimer Disease") |
| pmid:11230871 | p(FPLX:CHRN) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:17009926 | p(FPLX:CHRN) association path(MESH:"Behavior, Addictive") |
| pmid:26472524 | act(p(FPLX:CHRN)) increases path(MESH:"Behavior, Addictive") |
| pmid:17009926 | p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:17009926 | p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pmid:26472524 | p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:26472524 | p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pmid:17009926 | p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:17009926 | p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pmid:26472524 | p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:26472524 | p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pmid:17009926 | act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") |
| pmid:17009926 | act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") |
| pmid:17009926 | act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") |
| pmid:26472524 | act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") |
| pmid:17009926 | act(p(FPLX:CHRN)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:26472524 | p(FPLX:CHRN) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:26472524 | p(FPLX:CHRN) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pmid:25514383 | act(p(FPLX:CHRN)) increases a(CHEBI:"calcium(2+)") |
| pmid:17009926 | act(p(FPLX:CHRN)) increases sec(a(CHEBI:"glutamate(2-)")) |
| pmid:17009926 | p(FPLX:CHRN) increases sec(a(CHEBI:"glutamate(2-)")) |
| pmid:26472524 | act(p(FPLX:CHRN)) increases sec(a(CHEBI:"glutamate(2-)")) |
| pmid:17009926 | p(FPLX:CHRN) increases sec(a(CHEBI:"gamma-aminobutyric acid")) |
| pmid:17009926 | p(FPLX:CHRN) regulates act(complex(GO:"GABA-A receptor complex")) |
| pmid:17009926 | act(p(FPLX:CHRN)) increases bp(GO:"long term synaptic depression") |
| pmid:17009926 | act(p(FPLX:CHRN)) increases bp(GO:"regulation of action potential firing rate") |
| pmid:17009926 | p(FPLX:CHRN) association bp(GO:"regulation of action potential firing rate") |
| pmid:17009926 | p(FPLX:CHRN) increases bp(GO:"regulation of action potential firing rate") |
| pmid:17009926 | p(FPLX:CHRN) association bp(GO:"regulation of action potential firing pattern") |
| pmid:17009926 | act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Lewy Body Disease") |
| pmid:17009926 | p(FPLX:CHRN) negativeCorrelation path(MESH:"Lewy Body Disease") |
| pmid:17009926 | act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Down Syndrome") |
| pmid:17009926 | p(FPLX:CHRN) negativeCorrelation path(MESH:"Down Syndrome") |
| pmid:17009926 | act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Parkinson Disease") |
| pmid:17009926 | p(FPLX:CHRN) negativeCorrelation path(MESH:"Parkinson Disease") |
| pmid:11230871 | p(FPLX:CHRN) association path(MESH:"Parkinson Disease") |
| pmid:17009926 | p(FPLX:CHRN) association bp(GO:"response to pain") |
| pmid:17009926 | p(FPLX:CHRN) association path(MESH:Anxiety) |
| pmid:11230871 | p(FPLX:CHRN) association path(MESH:Anxiety) |
| pmid:17009926 | p(FPLX:CHRN) association path(MESH:Depression) |
| pmid:11230871 | p(FPLX:CHRN) association path(MESH:Depression) |
| pmid:17009926 | act(p(FPLX:CHRN)) increases path(MESH:Arousal) |
| pmid:28445721 | p(FPLX:CHRN) association path(MESH:Arousal) |
| pmid:17009926 | act(p(FPLX:CHRN)) increases bp(GO:"circadian sleep/wake cycle, REM sleep") |
| pmid:26472524 | p(FPLX:CHRN) increases tloc(a(CHEBI:"sodium(1+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:26472524 | p(FPLX:CHRN) increases tloc(a(CHEBI:"sodium(1+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pmid:26472524 | p(FPLX:CHRN) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:26472524 | p(FPLX:CHRN) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pmid:26813123 | p(FPLX:CHRN) increases bp(GO:cognition) |
| pmid:25514383 | p(FPLX:CHRN) regulates bp(GO:cognition) |
| pmid:28445721 | p(FPLX:CHRN) association bp(GO:cognition) |
| pmid:28445721 | p(FPLX:CHRN) increases bp(GO:cognition) |
| pmid:28445721 | p(FPLX:CHRN) association bp(GO:cognition) |
| pmid:11230871 | p(FPLX:CHRN) association bp(GO:cognition) |
| pmid:26813123 | p(FPLX:CHRN) decreases bp(HBP:Neurodegeneration) |
| pmid:25514383 | p(FPLX:CHRN) isA a(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors") |
| pmid:25514383 | p(FPLX:CHRN) regulates bp(GO:"potassium ion transport") |
| pmid:25514383 | p(FPLX:CHRN) regulates bp(GO:"sodium ion transport") |
| pmid:25514383 | p(FPLX:CHRN) regulates bp(GO:"calcium ion transport") |
| pmid:25514383 | act(p(FPLX:CHRN)) increases bp(MESH:"Synaptic Potentials") |
| pmid:25514383 | p(FPLX:CHRN) regulates path(MESH:"Cognition Disorders") |
| pmid:28445721 | p(FPLX:CHRN) association path(MESH:Motivation) |
| pmid:28445721 | act(p(FPLX:CHRN)) increases act(a(MESH:"Dopaminergic Neurons")) |
| pmid:28445721 | p(FPLX:CHRN) increases bp(GO:"positive regulation of synaptic plasticity") |
| pmid:28445721 | p(FPLX:CHRN) increases bp(GO:"dopamine secretion") |
| pmid:28445721 | p(FPLX:CHRN) association path(MESH:"Tobacco Use Disorder") |
| pmid:21482353 | act(p(FPLX:CHRN)) association path(MESH:"Tobacco Use Disorder") |
| pmid:21482353 | p(FPLX:CHRN) increases tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:11230871 | act(p(FPLX:CHRN)) regulates tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:21482353 | act(p(FPLX:CHRN)) association complex(p(FPLX:CHRN), p(HGNC:LYNX1)) |
| pmid:21482353 | surf(p(FPLX:CHRN)) association complex(p(FPLX:CHRN), p(HGNC:LYNX1)) |
| pmid:21482353 | p(FPLX:CHRN) regulates p(HGNC:LYNX1) |
| pmid:21482353 | act(p(FPLX:CHRN)) negativeCorrelation act(a(MESH:Brain)) |
| pmid:21482353 | act(p(FPLX:CHRN)) negativeCorrelation a(MESH:Neurons) |
| pmid:21482353 | p(FPLX:CHRN) regulates bp(GO:"GABAergic neuron differentiation") |
| pmid:21482353 | p(FPLX:CHRN) increases act(a(HP:"inhibitory interneuron")) |
| pmid:21482353 | p(FPLX:CHRN) increases act(p(FPLX:NOS)) |
| pmid:11230871 | p(FPLX:CHRN) association a(MESH:"Neurotransmitter Agents") |
| pmid:11230871 | p(FPLX:CHRN) association path(MESH:"Tourette Syndrome") |
| pmid:11230871 | p(FPLX:CHRN) negativeCorrelation path(MESH:"Cognitive Dysfunction") |
| pmid:11230871 | p(FPLX:CHRN) negativeCorrelation p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) |
| pmid:11230871 | p(FPLX:CHRN) negativeCorrelation a(MESH:"Amyloid beta-Peptides") |
| pmid:11230871 | p(FPLX:CHRN) negativeCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:11230871 | p(FPLX:CHRN) negativeCorrelation bp(GO:"response to oxidative stress") |
| pmid:21787755 | p(FPLX:CHRN) increases bp(GO:"maintenance of synapse structure") |
| pmid:21787755 | p(FPLX:CHRN) increases bp(GO:"neuron projection maintenance") |
| pmid:28445721 | bp(GO:"neurotransmitter secretion") regulates p(FPLX:CHRN) |
| pmid:21787755 | bp(GO:"neurotransmitter secretion") association a(HBP:"alpha-7-containing nAChR") |
| pmid:17009926 | bp(GO:"developmental process") association p(FPLX:CHRN) |
| pmid:17009926 | path(MESH:Epilepsy) association p(FPLX:CHRN) |
| pmid:17009926 | path(MESH:Epilepsy) association p(FPLX:CHRN) |
| pmid:11230871 | path(MESH:Epilepsy) association p(FPLX:CHRN) |
| pmid:21482353 | path(MESH:Epilepsy) positiveCorrelation p(HGNC:CHRNA4, var("?")) |
| pmid:21482353 | path(MESH:Epilepsy) positiveCorrelation p(HGNC:CHRNB2, var("?")) |
| pmid:21787755 | path(MESH:Epilepsy) association a(HBP:AβOs) |
| pmid:28901280 | path(MESH:Epilepsy) association p(MESH:"Receptors, Nicotinic") |
| pmid:17009926 | path(MESH:"Autistic Disorder") association p(FPLX:CHRN) |
| pmid:17009926 | path(MESH:"Autistic Disorder") negativeCorrelation act(p(FPLX:CHRN)) |
| pmid:17009926 | path(MESH:"Autistic Disorder") negativeCorrelation p(FPLX:CHRN) |
| pmid:26472524 | tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases bp(GO:"membrane depolarization") |
| pmid:17009926 | p(HGNC:CHRNA7, var("p.Leu254Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:17009926 | p(HGNC:CHRNA7, var("p.Leu254Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pmid:17009926 | p(HGNC:CHRNA7, var("p.Leu255Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:17009926 | p(HGNC:CHRNA7, var("p.Leu255Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pmid:17009926 | composite(a(CHEBI:acetylcholine), a(CHEBI:ivermectin)) increases act(p(FPLX:CHRN)) |
| pmid:17009926 | a(CHEBI:ivermectin) regulates act(p(HGNC:CHRNA7)) |
| pmid:17009926 | composite(a(CHEBI:"1,1-dimethyl-4-phenylpiperazinium iodide"), a(CHEBI:ivermectin)) increases act(p(HGNC:CHRNA7)) |
| pmid:17009926 | composite(a(CHEBI:"5-hydroxyindole"), a(CHEBI:acetylcholine)) increases act(p(HGNC:CHRNA7)) |
| pmid:17009926 | a(CHEBI:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea") regulates act(p(HGNC:CHRNA7)) |
| pmid:28132910 | a(CHEBI:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea") increases complex(a(GO:membrane), a(PUBCHEM:16068384)) |
| pmid:28132910 | a(CHEBI:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea") increases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384)) |
| pmid:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:acetylcholine)) |
| pmid:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:dopamine)) |
| pmid:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:noradrenaline)) |
| pmid:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:serotonin)) |
| pmid:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:"glutamate(2-)")) |
| pmid:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:"gamma-aminobutyric acid")) |
| pmid:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:memory) |
| pmid:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:memory) |
| pmid:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:learning) |
| pmid:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases path(MESH:Attention) |
| pmid:17009926 | a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:cognition) |
| pmid:19323834 | a(CHEBI:noradrenaline) increases p(HGNC:SUMO1) |
| pmid:17009926 | a(CHEBI:tetrodotoxin) decreases act(complex(GO:"voltage-gated calcium channel complex")) |
| pmid:17009926 | bp(GO:"regulation of action potential firing rate") association p(FPLX:CHRN) |
| pmid:17009926 | act(complex(GO:"GABA-A receptor complex")) increases bp(GO:"membrane depolarization") |
| pmid:17009926 | bp(GO:"regulation of action potential firing pattern") association p(FPLX:CHRN) |
| pmid:17009926 | bp(GO:"action potential") increases sec(a(CHEBI:dopamine)) |
| pmid:17009926 | path(MESH:"Lewy Body Disease") negativeCorrelation act(p(FPLX:CHRN)) |
| pmid:17009926 | path(MESH:"Lewy Body Disease") negativeCorrelation p(FPLX:CHRN) |
| pmid:27075649 | path(MESH:"Lewy Body Disease") positiveCorrelation a(HBP:HBP00016) |
| pmid:17009926 | bp(GO:"response to pain") association p(FPLX:CHRN) |
| pmid:17009926 | a(PUBCHEM:5311278) decreases act(p(HGNC:CHRNA7)) |
| pmid:17009926 | a(PUBCHEM:5311278) decreases bp(GO:memory) |
| pmid:25514383 | a(PUBCHEM:5311278) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:26813123 | p(FPLX:CHRM) isA a(MESH:"Receptors, G-Protein-Coupled") |
| pmid:26813123 | p(FPLX:CHRM) regulates a(MESH:"Ion Channels") |
| pmid:26813123 | p(FPLX:CHRM) regulates act(a(MESH:"Calcium Channels")) |
| pmid:26813123 | p(FPLX:CHRM) regulates act(a(MESH:"Potassium Channels")) |
| pmid:26813123 | act(p(FPLX:CHRM)) decreases act(a(MESH:"Potassium Channels")) |
| pmid:26813123 | p(FPLX:CHRM) regulates act(a(MESH:"Chloride Channels")) |
| pmid:26813123 | act(p(FPLX:CHRM)) decreases bp(GO:"synaptic transmission, glutamatergic") |
| pmid:25514383 | p(FPLX:CHRM) regulates bp(GO:cognition) |
| pmid:17009926 | p(HGNC:CHRNA4, var("p.Ser248Thr")) increases path(MESH:Epilepsy) |
| pmid:17009926 | g(HGNC:CHRNA4, var("?")) positiveCorrelation path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") |
| pmid:17009926 | path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") positiveCorrelation g(HGNC:CHRNA4, var("?")) |
| pmid:17009926 | path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") positiveCorrelation g(HGNC:CHRNB2, var("?")) |
| pmid:17009926 | g(HGNC:CHRNB2, var("?")) positiveCorrelation path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") |
| pmid:28445721 | path(MESH:Arousal) association p(FPLX:CHRN) |
| pmid:28901280 | path(MESH:Arousal) association p(MESH:"Receptors, Nicotinic") |
| pmid:23702978 | a(CHEBI:"potassium(1+)") decreases bp(GO:"apoptosome assembly") |
| pmid:23702978 | a(CHEBI:"potassium(1+)") increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pmid:23702978 | a(CHEBI:"potassium(1+)") increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:23702978 | a(CHEBI:"potassium(1+)") increases act(p(HGNC:PYCARD)) |
| pmid:23702978 | a(CHEBI:"potassium(1+)") decreases sec(p(HGNC:IL1B)) |
| pmid:24561250 | a(CHEBI:"potassium(1+)") increases act(complex(GO:"inflammasome complex")) |
| pmid:26472524 | act(p(MESH:"Receptors, N-Methyl-D-Aspartate")) increases bp(GO:"long-term synaptic potentiation") |
| pmid:26751493 | p(MESH:"Receptors, N-Methyl-D-Aspartate") association a(HBP:"projection domain") |
| pmid:16820021 | a(HBP:"SK and F 77434") decreases a(MESH:"8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol") |
| pmid:16820021 | a(MESH:antalarmin) causesNoChange act(p(RGD:Drd1)) |
| pmid:16820021 | a(MESH:antalarmin) increases p(RGD:Drd2) |
| pmid:16820021 | a(MESH:antalarmin) decreases p(RGD:Drd2) |
| pmid:16820021 | a(MESH:antalarmin) increases p(RGD:Drd3) |
| pmid:16820021 | a(MESH:antalarmin) decreases p(RGD:Drd3) |
| pmid:16820021 | a(MESH:antalarmin) decreases path(HBP:"isolation rearing") |
| pmid:16820021 | a(MESH:antalarmin) causesNoChange path(HBP:"isolation rearing") |
| pmid:16820021 | a(MESH:antalarmin) causesNoChange path(HBP:"isolation rearing") |
| pmid:16820021 | a(MESH:antalarmin) causesNoChange r(RGD:Bdnf) |
| pmid:16820021 | a(MESH:antalarmin) decreases r(RGD:Ntrk2) |
| pmid:16820021 | a(MESH:antalarmin) increases r(RGD:Ntrk2) |
| pmid:29807032 | a(MESH:antalarmin) decreases bp(MESH:"Heat-Shock Response") |
| pmid:29807032 | a(MESH:antalarmin) increases act(p(NCBIGENE:140621)) |
| pmid:29807032 | a(MESH:antalarmin) causesNoChange a(MESH:"Embryonic Structures") |
| pmid:23211705 | a(MESH:antalarmin) increases a(MESH:"Embryonic Structures") |
| pmid:23211705 | a(MESH:antalarmin) increases a(MESH:Morula) |
| pmid:23211705 | a(MESH:antalarmin) increases a(MESH:Blastocyst) |
| pmid:23211705 | a(MESH:antalarmin) decreases act(p(MGI:Crh)) |
| pmid:23211705 | a(MESH:antalarmin) decreases act(p(MGI:Crh)) |
| pmid:23211705 | a(MESH:antalarmin) decreases act(p(MGI:Crh)) |
| pmid:23211705 | a(MESH:antalarmin) decreases act(p(MGI:Crh)) |
| pmid:23211705 | a(MESH:antalarmin) regulates p(MGI:Crh) |
| pmid:16820021 | path(HBP:"isolation rearing") increases p(RGD:Drd2) |
| pmid:16820021 | path(HBP:"isolation rearing") increases p(RGD:Drd2) |
| pmid:16820021 | path(HBP:"isolation rearing") increases p(RGD:Drd3) |
| pmid:16820021 | path(HBP:"isolation rearing") increases p(RGD:Drd3) |
| pmid:16820021 | path(HBP:"isolation rearing") decreases r(RGD:Bdnf) |
| pmid:16820021 | path(HBP:"isolation rearing") increases r(RGD:Bdnf) |
| pmid:16820021 | path(HBP:"isolation rearing") decreases r(RGD:Ntrk2) |
| pmid:16820021 | path(HBP:"isolation rearing") increases r(RGD:Ntrk2) |
| pmid:11230871 | a(CHEBI:neurotransmitter) association bp(GO:cognition) |
| pmid:14556719 | sec(a(CHEBI:neurotransmitter)) association p(HGNC:SYT11, pmod(Ub)) |
| pmid:26813123 | bp(GO:"response to stress") association bp(GO:"synaptic transmission, cholinergic") |
| pmid:26813123 | bp(GO:"response to stress") regulates tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(MESH:"Basal Forebrain")) |
| pmid:26813123 | bp(GO:"regulation of circadian sleep/wake cycle, wakefulness") association bp(GO:"synaptic transmission, cholinergic") |
| pmid:26813123 | bp(GO:"regulation of circadian sleep/wake cycle, sleep") association bp(GO:"synaptic transmission, cholinergic") |
| pmid:26813123 | bp(GO:"sensory processing") association bp(GO:"synaptic transmission, cholinergic") |
| pmid:21482353 | bp(GO:"sensory processing") association bp(GO:"synaptic transmission, cholinergic") |
| pmid:24590577 | bp(GO:"circadian sleep/wake cycle") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pmid:26813123 | p(HGNC:SLC18A3) increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:cytosol), toLoc(MESH:"Synaptic Vesicles")) |
| pmid:26813123 | p(HGNC:SLC18A3) increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:cytosol), toLoc(MESH:"Synaptic Vesicles")) |
| pmid:26813123 | p(HGNC:SLC18A3) increases tloc(a(CHEBI:proton), fromLoc(MESH:"Synaptic Vesicles"), toLoc(GO:cytosol)) |
| pmid:26813123 | bp(GO:"calcium ion import") regulates act(p(HGNC:CHAT)) |
| pmid:26813123 | p(HGNC:CHAT, pmod(Ph)) regulates act(p(HGNC:CHAT)) |
| pmid:26813123 | a(CHEBI:"2-(4-phenyl-1-piperidinyl)-1-cyclohexanol") decreases act(p(HGNC:SLC18A3)) |
| pmid:26813123 | a(CHEBI:"2-(4-phenyl-1-piperidinyl)-1-cyclohexanol") decreases tloc(a(CHEBI:acetylcholine), fromLoc(GO:cytosol), toLoc(MESH:"Synaptic Vesicles")) |
| pmid:26813123 | p(MGI:Slc18a3) decreases path(MESH:"Neuromuscular Diseases") |
| pmid:26813123 | p(MGI:Slc18a3) increases bp(GO:cognition) |
| pmid:26813123 | a(CHEBI:"organophosphorus compound") decreases act(p(HGNC:ACHE)) |
| pmid:26813123 | a(CHEBI:antidote) increases act(p(HGNC:ACHE)) |
| pmid:26813123 | a(CHEBI:doxylamine) increases act(p(HGNC:ACHE)) |
| pmid:26813123 | a(CHEBI:succinylcholine) decreases act(p(HGNC:ACHE)) |
| pmid:26813123 | p(MGI:Slc5a7) decreases path(MESH:Death) |
| pmid:26813123 | complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) association bp(GO:"action potential initiation") |
| pmid:26813123 | a(MESH:"Basal Nucleus of Meynert") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26813123 | p(FPLX:CHRN, pmod(Ph)) regulates act(p(FPLX:CHRN)) |
| pmid:26813123 | a(MESH:"Protein-Tyrosine Kinases") increases p(FPLX:CHRN, pmod(Ph)) |
| pmid:26813123 | complex(a(CHEBI:"1,1-dimethyl-4-phenylpiperazinium iodide"), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) |
| pmid:26813123 | complex(a(CHEBI:cystine), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) |
| pmid:26813123 | complex(a(CHEBI:nicotine), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) |
| pmid:11230871 | complex(a(CHEBI:nicotine), p(FPLX:CHRN)) association bp(GO:cognition) |
| pmid:26813123 | a(CHEBI:tubocurarine) decreases act(p(FPLX:CHRN)) |
| pmid:29626319 | a(MESH:"Receptors, G-Protein-Coupled") increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:26813123 | complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC)) |
| pmid:26813123 | complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:"myo-inositol") |
| pmid:26813123 | complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) |
| pmid:26813123 | complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") |
| pmid:26813123 | complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26813123 | complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases bp(GO:cognition) |
| pmid:26813123 | complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC)) |
| pmid:26813123 | complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:"myo-inositol") |
| pmid:26813123 | complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) |
| pmid:26813123 | complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") |
| pmid:26813123 | complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC)) |
| pmid:26813123 | complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:"myo-inositol") |
| pmid:26813123 | complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) |
| pmid:26813123 | complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") |
| pmid:26813123 | complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases p(FPLX:ADCY) |
| pmid:26813123 | complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases a(CHEBI:"3',5'-cyclic AMP") |
| pmid:26813123 | complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases act(a(MESH:"Calcium Channels")) |
| pmid:26813123 | complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases p(FPLX:ADCY) |
| pmid:26813123 | complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases a(CHEBI:"3',5'-cyclic AMP") |
| pmid:26813123 | complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases act(a(MESH:"Calcium Channels")) |
| pmid:26088141 | act(a(MESH:"Calcium Channels")) association act(a(CHEBI:choline)) |
| pmid:26088141 | act(a(MESH:"Calcium Channels")) association a(CHEBI:"calcium(2+)") |
| pmid:26813123 | complex(a(CHEBI:Muscarine), p(FPLX:CHRM)) increases act(p(FPLX:CHRM)) |
| pmid:26813123 | a(MESH:"Quinuclidinyl Benzilate") decreases act(p(FPLX:CHRM)) |
| pmid:26813123 | a(MESH:"Receptors, Cholinergic") increases bp(GO:memory) |
| pmid:25514383 | a(MESH:"Receptors, Cholinergic") increases path(MESH:Attention) |
| pmid:26813123 | path(MESH:Apathy) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26813123 | p(MGI:Chrm4) decreases tloc(a(CHEBI:dopamine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:24590577 | p(MGI:Chrm4) decreases act(a(CHEBI:phencyclidine)) |
| pmid:24590577 | p(MGI:Chrm4) decreases bp(GO:"locomotor rhythm") |
| pmid:24590577 | p(MGI:Chrm4) decreases act(p(MGI:Drd1)) |
| pmid:26813123 | path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation a(MESH:"Cholinergic Neurons") |
| pmid:14556719 | path(MESH:"Amyotrophic Lateral Sclerosis") decreases a(MESH:"Brain Stem") |
| pmid:14556719 | path(MESH:"Amyotrophic Lateral Sclerosis") decreases bp(GO:"spinal cord development") |
| pmid:14556719 | path(MESH:"Amyotrophic Lateral Sclerosis") decreases a(MESH:"Pyramidal Tracts") |
| pmid:14556719 | path(MESH:"Amyotrophic Lateral Sclerosis") increases path(MESH:Paralysis) |
| pmid:14556719 | path(MESH:"Amyotrophic Lateral Sclerosis") increases bp(GO:"neuron death") |
| pmid:14556719 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SOD1, var("?")) |
| pmid:14556719 | path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:RNF19A) |
| pmid:14556719 | path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:UBL5) |
| pmid:25784053 | path(MESH:"Amyotrophic Lateral Sclerosis") increases bp(GO:autophagy) |
| pmid:25784053 | path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation p(HGNC:ATF6) |
| pmid:30116051 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SQSTM1) |
| pmid:30116051 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:CHMP2B) |
| pmid:30116051 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:TBK1) |
| pmid:30116051 | path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:OPTN) |
| pmid:26813123 | path(MESH:"Supranuclear Palsy, Progressive") negativeCorrelation a(MESH:"Cholinergic Neurons") |
| pmid:30126037 | path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT) |
| pmid:30126037 | path(MESH:"Supranuclear Palsy, Progressive") increases a(HBP:HBP00045) |
| pmid:30126037 | path(MESH:"Supranuclear Palsy, Progressive") increases a(GO:"neurofibrillary tangle") |
| pmid:30126037 | path(MESH:"Supranuclear Palsy, Progressive") increases bp(HP:Neurodegeneration) |
| pmid:30126037 | path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:Gliosis) |
| pmid:30126037 | path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:"Motor Disorders") |
| pmid:30126037 | path(MESH:"Supranuclear Palsy, Progressive") association path(MESH:"Parkinsonian Disorders") |
| pmid:30126037 | path(MESH:"Supranuclear Palsy, Progressive") association path(MESH:Tauopathies) |
| pmid:29311797 | path(MESH:"Supranuclear Palsy, Progressive") isA path(MESH:Tauopathies) |
| pmid:30126037 | path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:"Cognitive Dysfunction") |
| pmid:30126037 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:CDKN2A) |
| pmid:28420982 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:26751493 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HBP:"4R tau") |
| pmid:12578227 | path(MESH:"Supranuclear Palsy, Progressive") increases p(HGNC:TGM1) |
| pmid:12578227 | path(MESH:"Supranuclear Palsy, Progressive") increases r(HGNC:TGM1) |
| pmid:12578227 | path(MESH:"Supranuclear Palsy, Progressive") increases r(HBP:"TGM2 Isoform 3 (349 aa)") |
| pmid:12578227 | path(MESH:"Supranuclear Palsy, Progressive") increases r(HGNC:TGM2) |
| pmid:11089576 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation act(p(ECCODE:"2.3.2.13")) |
| pmid:22057784 | path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) |
| pmid:17050703 | path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) |
| pmid:29281045 | path(MESH:"Supranuclear Palsy, Progressive") decreases p(HGNC:LCMT1) |
| pmid:29281045 | path(MESH:"Supranuclear Palsy, Progressive") increases p(ECCODE:"3.1.1.89") |
| pmid:26813123 | path(MESH:"Olivopontocerebellar Atrophies") negativeCorrelation a(MESH:"Cholinergic Neurons") |
| pmid:26813123 | act(a(GO:"cholinergic synapse")) association a(HBP:"amyloid-beta oligomers") |
| pmid:26813123 | a(GO:synapse) negativeCorrelation path(MESH:"Cognitive Dysfunction") |
| pmid:25514383 | a(GO:synapse) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28445721 | act(a(GO:synapse)) regulates p(FPLX:CHRN) |
| pmid:27807169 | a(GO:synapse) positiveCorrelation p(RGD:Cdk5r2) |
| pmid:22156579 | a(GO:synapse) negativeCorrelation p(HGNC:MARK4) |
| pmid:26813123 | p(HGNC:SYP) association bp(GO:memory) |
| pmid:26813123 | complex(a(MESH:"Amyloid beta-Peptides"), p(HGNC:ACHE)) increases a(HBP:"amyloid-beta fibrils") |
| pmid:26813123 | p(MGI:App, var("?")) decreases tloc(a(CHEBI:choline), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:26813123 | p(MGI:App, var("?")) decreases p(FPLX:CHRM) |
| pmid:26813123 | p(MGI:App, var("?")) decreases p(FPLX:CHRN) |
| pmid:26813123 | a(PUBCHEM:10013505) increases act(p(HGNC:CHRM1)) |
| pmid:26813123 | a(PUBCHEM:10013505) increases bp(GO:cognition) |
| pmid:26813123 | a(PUBCHEM:10013505) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:26813123 | a(PUBCHEM:10013505) decreases p(HGNC:MAPT, var("?")) |
| pmid:26813123 | a(PUBCHEM:10013505) increases a(MESH:"Amyloid Precursor Protein Secretases") |
| pmid:30116051 | p(HGNC:MAPT, var("?")) decreases act(complex(GO:"proteasome complex")) |
| pmid:30116051 | p(HGNC:MAPT, var("?")) decreases bp(GO:"chaperone-mediated autophagy") |
| pmid:29215007 | p(HGNC:MAPT, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21882945 | p(HGNC:MAPT, var("?")) increases a(HBP:"Tau aggregates") |
| pmid:21882945 | p(HGNC:MAPT, var("?")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:26813123 | a(PUBCHEM:9867750) increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:26813123 | a(PUBCHEM:9867750) increases act(p(HGNC:CHRM1)) |
| pmid:26813123 | a(PUBCHEM:9867750) increases act(a(MESH:"Receptors, Nicotinic")) |
| pmid:26813123 | a(PUBCHEM:9867750) increases bp(GO:cognition) |
| pmid:26813123 | a(PUBCHEM:1476756) increases bp(GO:"excitatory postsynaptic potential") |
| pmid:26813123 | a(PUBCHEM:1476756) increases bp(GO:memory) |
| pmid:24027553 | a(HBP:Excitotoxicity) association act(p(HGNCGENEFAMILY:Calpains)) |
| pmid:25899010 | a(HBP:Excitotoxicity) positiveCorrelation p(HGNC:DAPK1) |
| pmid:26813123 | a(MESH:"Nerve Growth Factor") increases a(MESH:"Cholinergic Neurons") |
| pmid:26813123 | a(MESH:"Nerve Growth Factor") increases a(MESH:"Cholinergic Neurons") |
| pmid:26813123 | a(MESH:"Nerve Growth Factor") increases bp(GO:memory) |
| pmid:11230871 | a(MESH:"Nerve Growth Factor") increases complex(a(CHEBI:nicotine), p(FPLX:CHRN)) |
| pmid:16273023 | path(MESH:D000544) association path(MESH:D016874) |
| pmid:18986241 | path(MESH:D000544) increases path(MESH:D016874) |
| pmid:16273023 | path(MESH:D000544) association path(MESH:D058225) |
| pmid:16273023 | path(MESH:D000544) association bp(GO:"GO:0070997") |
| pmid:16273023 | path(MESH:D000544) decreases bp(MESH:D009435) |
| pmid:16273023 | path(MESH:D000544) decreases bp(GO:"GO:0007271") |
| pmid:16273023 | path(MESH:D000544) decreases bp(GO:"GO:0035249") |
| pmid:16273023 | path(MESH:D000544) decreases act(p(HGNC:CHAT), ma(cat)) |
| pmid:18986241 | path(MESH:D000544) decreases p(HGNC:CHAT) |
| pmid:16273023 | path(MESH:D000544) decreases bp(GO:"GO:0015871") |
| pmid:16273023 | path(MESH:D000544) decreases bp(GO:"GO:0008292") |
| pmid:16273023 | path(MESH:D000544) causesNoChange p(MESH:D011950) |
| pmid:16273023 | path(MESH:D000544) decreases bp(GO:"GO:0051935") |
| pmid:16273023 | path(MESH:D000544) decreases bp(GO:"GO:0014047") |
| pmid:16273023 | path(MESH:D000544) decreases bp(GO:"GO:0014047") |
| pmid:16273023 | path(MESH:D000544) decreases bp(MESH:D017774) |
| pmid:16273023 | path(MESH:D000544) decreases bp(MESH:D017774) |
| pmid:16273023 | path(MESH:D000544) decreases complex(a(CHEBI:"magnesium(2+)"), p(GFAM:"Glutamate ionotropic receptor NMDA type subunits")) |
| pmid:18986241 | path(MESH:D000544) association path(MESH:D019636) |
| pmid:18986241 | path(MESH:D000544) association path(MESH:D008568) |
| pmid:18986241 | path(MESH:D000544) association path(MESH:D003071) |
| pmid:18986241 | path(MESH:D000544) association path(MESH:D001526) |
| pmid:18986241 | path(MESH:D000544) association path(HBP:aMCI) |
| pmid:18986241 | path(MESH:D000544) decreases a(MESH:D059329) |
| pmid:18986241 | path(MESH:D000544) association a(MESH:D059329) |
| pmid:18986241 | path(MESH:D000544) decreases a(MESH:D059329) |
| pmid:18986241 | path(MESH:D000544) association a(MESH:D016874) |
| pmid:18986241 | path(MESH:D000544) decreases p(HGNC:ACHE) |
| pmid:18986241 | path(MESH:D000544) causesNoChange act(p(HGNC:ACHE)) |
| pmid:18986241 | path(MESH:D000544) decreases act(p(HGNC:ACHE)) |
| pmid:18986241 | path(MESH:D000544) decreases act(p(HGNC:ACHE)) |
| pmid:18986241 | path(MESH:D000544) increases act(p(HGNC:BCHE)) |
| pmid:18986241 | path(MESH:D000544) causesNoChange p(HGNC:SLC18A3) |
| pmid:18986241 | path(MESH:D000544) increases path(MESH:D001284) |
| pmid:18986241 | path(MESH:D000544) increases a(MESHC:"pro-nerve growth factor, human") |
| pmid:18986241 | path(MESH:D000544) decreases p(HGNC:NTRK1) |
| pmid:18986241 | path(MESH:D000544) increases p(HGNC:NGF) |
| pmid:18986241 | path(MESH:D000544) association p(HGNC:SORT1) |
| pmid:18986241 | path(MESH:D000544) decreases bp(GO:"GO:0032455") |
| pmid:18986241 | path(MESH:D000544) increases act(p(HGNC:MMP9)) |
| pmid:18986241 | path(MESH:D000544) decreases g(HGNC:NTRK1) |
| pmid:18986241 | path(MESH:D000544) decreases g(HGNC:NTRK2) |
| pmid:18986241 | path(MESH:D000544) decreases g(HGNC:NTRK3) |
| pmid:18986241 | path(MESH:D000544) increases g(HGNC:NGFR) |
| pmid:18986241 | path(MESH:D000544) causesNoChange r(HGNC:CHAT) |
| pmid:18986241 | path(MESH:D000544) increases r(HGNC:CHRNA7) |
| pmid:18986241 | path(MESH:D000544) increases r(HGNC:CHRNA7) |
| pmid:18986241 | path(MESH:D000544) causesNoChange r(HGNC:CHRM1) |
| pmid:18986241 | path(MESH:D000544) decreases r(HGNC:SYP) |
| pmid:18986241 | path(MESH:D000544) decreases r(GFAM:Synaptotagmins) |
| pmid:18986241 | path(MESH:D000544) causesNoChange r(HGNC:VAMP1) |
| pmid:18986241 | path(MESH:D000544) causesNoChange r(HGNC:SNAP29) |
| pmid:18986241 | path(MESH:D000544) causesNoChange r(HGNC:APP) |
| pmid:18986241 | path(MESH:D000544) causesNoChange r(HGNC:NOTCH1) |
| pmid:18986241 | path(MESH:D000544) increases r(HGNC:CTSD) |
| pmid:18986241 | path(MESH:D000544) decreases r(HGNC:PPP1CA) |
| pmid:18986241 | path(MESH:D000544) decreases r(HGNC:PPP1CC) |
| pmid:18986241 | path(MESH:D000544) causesNoChange r(HGNC:MAPT) |
| pmid:18986241 | path(MESH:D000544) decreases a(HBP:"3R tau") |
| pmid:16273023 | path(MESH:D016874) association path(MESH:D000544) |
| pmid:18986241 | path(MESH:D016874) association bp(HBP:hyperphosphorylation) |
| pmid:16273023 | path(MESH:D058225) association path(MESH:D000544) |
| pmid:18986241 | path(MESH:D058225) association p(HGNC:BCHE) |
| pmid:18986241 | path(MESH:D058225) association p(HGNC:ACHE) |
| pmid:16273023 | bp(GO:"GO:0070997") association path(MESH:D000544) |
| pmid:16273023 | bp(GO:"GO:0070997") association act(p(MESH:D017470)) |
| pmid:16273023 | bp(GO:"GO:0007271") association path(MESH:D003071) |
| pmid:16273023 | bp(GO:"GO:0007271") association path(MESH:D003071) |
| pmid:16273023 | bp(GO:"GO:0007271") association a(MESH:D002800) |
| pmid:16273023 | bp(GO:"GO:0035249") association path(MESH:D003071) |
| pmid:16273023 | bp(GO:"GO:0035249") association path(MESH:D003071) |
| pmid:16273023 | bp(GO:"GO:0035249") increases bp(GO:"GO:0051935") |
| pmid:16273023 | bp(GO:"GO:0035249") association a(CHEBI:"NMDA receptor antagonist") |
| pmid:16273023 | path(MESH:D003071) association bp(GO:"GO:0035249") |
| pmid:16273023 | path(MESH:D003071) association bp(GO:"GO:0035249") |
| pmid:16273023 | path(MESH:D003071) association bp(GO:"GO:0007271") |
| pmid:16273023 | path(MESH:D003071) association bp(GO:"GO:0007271") |
| pmid:18986241 | path(MESH:D003071) association path(MESH:D000544) |
| pmid:18986241 | path(MESH:D003071) association p(HGNC:BCHE) |
| pmid:18986241 | path(MESH:D003071) association g(HGNC:NTRK1) |
| pmid:18986241 | path(MESH:D003071) association g(HGNC:NTRK2) |
| pmid:18986241 | path(MESH:D003071) association g(HGNC:NTRK3) |
| pmid:18986241 | path(MESH:D003071) negativeCorrelation r(HGNC:CHRNA7) |
| pmid:18986241 | path(MESH:D003071) association act(p(HGNC:GAL)) |
| pmid:16273023 | bp(GO:"GO:0008292") association path(MESH:D003704) |
| pmid:16273023 | path(MESH:D003704) association bp(GO:"GO:0008292") |
| pmid:18986241 | path(MESH:D003704) association path(HBP:aMCI) |
| pmid:18986241 | path(MESH:D003704) association a(MESH:D059329) |
| pmid:18986241 | path(MESH:D003704) decreases p(HGNC:ACHE) |
| pmid:16273023 | path(MESH:D013850) association a(MESH:D006624) |
| pmid:16273023 | path(MESH:D013850) association a(MESH:D019579) |
| pmid:16273023 | path(MESH:D013850) association a(CHEBI:"glutamate(1-)") |
| pmid:16273023 | a(MESH:D006624) association path(MESH:D013850) |
| pmid:16273023 | a(MESH:D006624) association path(MESH:D008568) |
| pmid:16273023 | a(MESH:D019579) association path(MESH:D013850) |
| pmid:16273023 | a(MESH:D019579) association path(MESH:D008568) |
| pmid:16273023 | a(CHEBI:"glutamate(1-)") association path(MESH:D013850) |
| pmid:16273023 | a(CHEBI:"glutamate(1-)") association path(MESH:D008568) |
| pmid:27087442 | a(CHEBI:"glutamate(1-)") increases p(HBP:"CDK5R1 p25") |
| pmid:16273023 | path(MESH:D008568) association a(MESH:D006624) |
| pmid:16273023 | path(MESH:D008568) association a(MESH:D019579) |
| pmid:16273023 | path(MESH:D008568) association a(CHEBI:"glutamate(1-)") |
| pmid:16273023 | path(MESH:D008568) association bp(MESH:D017774) |
| pmid:18986241 | path(MESH:D008568) association path(MESH:D000544) |
| pmid:18986241 | path(MESH:D008568) association a(MESH:D059329) |
| pmid:16273023 | act(p(HGNC:GLS), ma(cat)) directlyIncreases a(CHEBI:"glutamate(1-)") |
| pmid:16273023 | bp(GO:"GO:0014047") increases bp(GO:"GO:0035249") |
| pmid:16273023 | bp(GO:"GO:0014047") increases bp(MESH:D017774) |
| pmid:16273023 | bp(GO:"GO:0051935") increases a(CHEBI:glutamine) |
| pmid:16273023 | a(CHEBI:glutamine) increases bp(GO:"GO:0006868") |
| pmid:16273023 | act(p(MESH:D017470)) association bp(GO:"GO:0070997") |
| pmid:16273023 | bp(MESH:D017774) association path(MESH:D008568) |
| pmid:16273023 | bp(MESH:D017774) association path(MESH:D007858) |
| pmid:16273023 | path(MESH:D007858) association bp(MESH:D017774) |
| pmid:16273023 | a(MESH:D017966) association composite(p(MESH:D011950), p(MESH:D017470)) |
| pmid:16273023 | composite(p(MESH:D011950), p(MESH:D017470)) association a(MESH:D017966) |
| pmid:16273023 | a(MESH:D002800) increases bp(GO:"GO:0014047") |
| pmid:16273023 | a(MESH:D002800) increases bp(GO:"GO:0014047") |
| pmid:16273023 | a(MESH:D002800) increases a(CHEBI:acetylcholine) |
| pmid:16273023 | a(MESH:D002800) association bp(GO:"GO:0007271") |
| pmid:18986241 | a(MESH:D002800) decreases path(MESH:D000544) |
| pmid:18986241 | a(MESH:D002800) decreases a(CHEBI:"amyloid-beta") |
| pmid:18986241 | a(MESH:D002800) increases bp(MESH:D000066829) |
| pmid:18986241 | a(MESH:D002800) association bp(GO:"GO:0050435") |
| pmid:18986241 | a(MESH:D002800) association path(MESH:D007319) |
| pmid:18986241 | a(MESH:D002800) association path(MESH:D003967) |
| pmid:18986241 | a(MESH:D002800) association path(MESH:D009325) |
| pmid:18986241 | a(MESH:D002800) association path(MESH:D005221) |
| pmid:18986241 | a(MESH:D002800) association path(MESH:D000855) |
| pmid:16273023 | complex(a(CHEBI:acetylcholine), p(MESH:D011950)) increases a(CHEBI:acetylcholine) |
| pmid:16273023 | a(CHEBI:"magnesium(2+)") decreases complex(a(CHEBI:"calcium(2+)"), p(GFAM:"Glutamate ionotropic receptor NMDA type subunits")) |
| pmid:16273023 | act(p(GFAM:"Glutamate ionotropic receptor NMDA type subunits")) decreases bp(MESH:D017774) |
| pmid:24590577 | a(HBP:"Tau aggregates") increases path(MESH:"Neurofibrillary Tangles") |
| pmid:24027553 | a(HBP:"Tau aggregates") increases path(MESH:"Neurofibrillary Tangles") |
| pmid:24027553 | a(HBP:"Tau aggregates") positiveCorrelation path(HBP:neurotoxicity) |
| pmid:24027553 | a(HBP:"Tau aggregates") decreases act(p(HGNCGENEFAMILY:Proteasome)) |
| pmid:24027553 | a(HBP:"Tau aggregates") positiveCorrelation a(MESH:Autophagosomes) |
| pmid:27574109 | a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal transport") |
| pmid:29590627 | a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) |
| pmid:29590627 | a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) |
| pmid:29590627 | a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) |
| pmid:26751493 | a(HBP:"Tau aggregates") positiveCorrelation tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) |
| pmid:26751493 | tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) positiveCorrelation a(HBP:"Tau aggregates") |
| pmid:29590627 | a(HBP:"Tau aggregates") association a(GO:"early endosome") |
| pmid:29590627 | a(HBP:"Tau aggregates") association a(GO:"late endosome") |
| pmid:29590627 | a(HBP:"Tau aggregates") association a(GO:lysosome) |
| pmid:23528736 | a(HBP:"Tau aggregates") association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:21882945 | a(HBP:"Tau aggregates") increases path(MESH:Tauopathies) |
| pmid:29311797 | a(HBP:"Tau aggregates") increases path(MESH:Tauopathies) |
| pmid:28420982 | a(HBP:"Tau aggregates") increases a(GO:"neurofibrillary tangle") |
| pmid:28420982 | a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") |
| pmid:22817713 | a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") |
| pmid:22817713 | a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") |
| pmid:22817713 | a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") |
| pmid:28420982 | a(HBP:"Tau aggregates") association bp(MESH:"Neuronal Plasticity") |
| pmid:28420982 | a(HBP:"Tau aggregates") association sec(p(HGNC:MAPT)) |
| pmid:28420982 | a(HBP:"Tau aggregates") association a(CHEBI:dextran) |
| pmid:29311797 | a(HBP:"Tau aggregates") association p(HGNC:HDAC6) |
| pmid:29311797 | a(HBP:"Tau aggregates") association bp(GO:"glucocorticoid receptor signaling pathway") |
| pmid:27373205 | a(HBP:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22817713 | a(HBP:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22817713 | a(HBP:"Tau aggregates") increases act(p(HGNC:PPP1CA)) |
| pmid:22817713 | a(HBP:"Tau aggregates") increases act(p(HGNC:GSK3A)) |
| pmid:22817713 | a(HBP:"Tau aggregates") association p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:22817713 | a(HBP:"Tau aggregates") association p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:25125464 | a(HBP:"Tau aggregates") positiveCorrelation p(MGI:Crhr1) |
| pmid:21734277 | bp(GO:"axonal transport") negativeCorrelation act(p(HGNC:PPP1CA)) |
| pmid:24590577 | complex(a(CHEBI:acetylcholine), p(FPLX:"G_protein"), p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) increases bp(GO:"synaptic transmission, cholinergic") |
| pmid:24590577 | complex(p(HGNC:CHRM1), p(HGNC:GNA11)) increases act(p(FPLX:PLC)) |
| pmid:24590577 | complex(p(HGNC:CHRM1), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport") |
| pmid:24590577 | complex(p(HGNC:CHRM3), p(HGNC:GNA11)) increases act(p(FPLX:PLC)) |
| pmid:24590577 | complex(p(HGNC:CHRM3), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport") |
| pmid:24590577 | complex(p(HGNC:CHRM5), p(HGNC:GNA11)) increases act(p(FPLX:PLC)) |
| pmid:24590577 | complex(p(HGNC:CHRM5), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport") |
| pmid:24590577 | complex(p(HGNC:CHRM2), p(HGNC:GNAO1)) decreases p(HGNCGENEFAMILY:"Adenylate cyclases") |
| pmid:24590577 | complex(p(HGNC:CHRM2), p(HGNC:GNAO1)) decreases a(CHEBI:"3',5'-cyclic AMP") |
| pmid:24590577 | complex(p(HGNC:CHRM4), p(HGNC:GNAO1)) decreases p(HGNCGENEFAMILY:"Adenylate cyclases") |
| pmid:24590577 | complex(p(HGNC:CHRM4), p(HGNC:GNAO1)) decreases a(CHEBI:"3',5'-cyclic AMP") |
| pmid:24590577 | path(MESH:Nociception) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pmid:24590577 | a(MESH:Kidney) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| pmid:29626319 | a(MESH:Kidney) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(MESH:Kidney) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(MESH:Kidney) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(MESH:Kidney) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:29626319 | a(MESH:Kidney) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:24590577 | a(MESH:Thalamus) association p(HGNC:CHRM1) |
| pmid:24762290 | a(MESH:Thalamus) association complex(HBP:"alpha-4 beta-2 nAChR") |
| pmid:24762290 | a(MESH:Thalamus) association complex(HBP:"alpha-4 beta-2 nAChR") |
| pmid:24590577 | p(MGI:Chrm2) decreases path(MESH:"Nociceptive Pain") |
| pmid:24590577 | a(MESH:Hypothalamus) association p(HGNC:CHRM3) |
| pmid:24590577 | p(MGI:Chrm3) regulates bp(GO:"response to food") |
| pmid:24590577 | p(MGI:Chrm3) increases bp(GO:"pituitary gland development") |
| pmid:24590577 | p(MGI:Chrm3) increases p(MGI:Prl) |
| pmid:24590577 | p(MGI:Chrm3) increases p(MGI:Gh) |
| pmid:24590577 | p(MGI:Chrm3) increases bp(GO:"multicellular organism growth") |
| pmid:24590577 | a(CHEBI:benzoxazine) decreases path(MESH:"Parkinson Disease") |
| pmid:24590577 | a(MESH:"Pars Compacta") association p(HGNC:CHRM5) |
| pmid:24027553 | bp(HBP:"APP processing") association p(HGNC:HTRA1) |
| pmid:24027553 | bp(HBP:"APP processing") association path(MESH:"Alzheimer Disease") |
| pmid:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(MGI:Bace1) |
| pmid:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases a(CHEBI:"amyloid-beta") |
| pmid:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases path(MESH:"Plaque, Amyloid") |
| pmid:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") increases bp(GO:memory) |
| pmid:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") increases bp(GO:learning) |
| pmid:24590577 | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:24401760 | p(MGI:Bace1) positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:24590577 | complex(p(HGNC:BACE1), p(HGNC:CHRM1)) increases deg(p(HGNC:BACE1)) |
| pmid:29686391 | bp(HBP:neurotoxicity) positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:24590577 | bp(GO:"Wnt signaling pathway") decreases bp(HBP:neurotoxicity) |
| pmid:18494933 | bp(GO:"Wnt signaling pathway") negativeCorrelation act(p(HGNC:GSK3B)) |
| pmid:24590577 | a(MESH:cevimeline) increases act(p(HGNC:CHRM1)) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Caspases)) positiveCorrelation path(MESH:"Neurofibrillary Tangles") |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Caspases)) association path(MESH:"Neurofibrillary Tangles") |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Caspases)) association path(MESH:Inflammation) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Caspases)) increases a(HBP:"Tau aggregates") |
| pmid:24590577 | a(MESH:"1-((4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid") increases act(p(MGI:Chrm1)) |
| pmid:24590577 | a(MESH:"1-((4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid") increases bp(GO:memory) |
| pmid:24590577 | a(MESH:"1-((4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid") increases path(MESH:"Executive Function") |
| pmid:24590577 | complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) increases a(HBP:"sAPP-alpha") |
| pmid:24590577 | complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) decreases a(CHEBI:"amyloid-beta") |
| pmid:24590577 | complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) increases bp(GO:"signal transduction") |
| pmid:24590577 | a(CHEBI:cevimeline) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:24590577 | a(CHEBI:cevimeline) decreases path(MESH:"Sjogren's Syndrome") |
| pmid:24590577 | a(CHEBI:cevimeline) decreases a(CHEBI:"amyloid-beta") |
| pmid:24590577 | a(CHEBI:cevimeline) causesNoChange a(HBP:"sAPP-alpha") |
| pmid:24590577 | a(CHEBI:cevimeline) increases path(MESH:Confusion) |
| pmid:24590577 | a(CHEBI:cevimeline) increases path(MESH:Diarrhea) |
| pmid:24590577 | a(CHEBI:cevimeline) increases path(MESH:Asthenia) |
| pmid:24590577 | a(CHEBI:cevimeline) increases path(MESH:"Gastrointestinal Diseases") |
| pmid:24590577 | a(MESH:"talsaclidine fumarate") increases a(HBP:"sAPP-alpha") |
| pmid:24590577 | a(MESH:"talsaclidine fumarate") decreases a(CHEBI:"amyloid-beta") |
| pmid:24590577 | a(MESH:"talsaclidine fumarate") increases path(MESH:Sweating) |
| pmid:24590577 | a(MESH:"talsaclidine fumarate") increases path(MESH:Salivation) |
| pmid:24590577 | a(MESH:"WAY 132983") increases bp(GO:cognition) |
| pmid:24590577 | a(MESH:"WAY 132983") increases path(MESH:Salivation) |
| pmid:24590577 | a(MESH:"WAY 132983") increases path(MESH:Hypothermia) |
| pmid:24590577 | a(HBP:VU0029767) increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1)) |
| pmid:24590577 | a(HBP:VU0090157) increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1)) |
| pmid:24590577 | a(MESH:"Antipsychotic Agents") association a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") |
| pmid:24590577 | a(HBP:VU0184670) increases act(p(HGNC:CHRM1)) |
| pmid:24590577 | a(HBP:VU0184670) increases bp(GO:"NMDA selective glutamate receptor signaling pathway") |
| pmid:26088141 | p(HGNC:GNAS) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAS)) |
| pmid:26088141 | p(HGNC:GNAI2) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAI2)) |
| pmid:26088141 | p(HGNCGENEFAMILY:"G protein subunits beta") increases complex(p(FPLX:"G_protein"), p(HGNC:CHRNA7)) |
| pmid:26088141 | composite(p(HBP:"alpha-Bungarotoxin"), p(HGNC:CHRNA7), p(MESH:"Heterotrimeric GTP-Binding Proteins")) increases complex(a(HBP:"alpha-Bungarotoxin"), p(MESH:"Heterotrimeric GTP-Binding Proteins")) |
| pmid:26088141 | p(HBP:"GPBC, alpha-7 nAChR") orthologous p(HBP:"GPBC, Glycine Receptor 1") |
| pmid:26088141 | p(HBP:"GPBC, Glycine Receptor 1") orthologous p(HBP:"GPBC, alpha-7 nAChR") |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) increases bp(HBP:"nAChR assembly") |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) increases p(HGNC:CHRNA7) |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases act(a(CHEBI:choline)) |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases a(CHEBI:"calcium(2+)") |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases act(a(CHEBI:"calcium(2+)", loc(GO:intracellular))) |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases bp(GO:"calcium-mediated signaling") |
| pmid:26088141 | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases bp(MESH:"Pleckstrin Homology Domains") |
| pmid:26088141 | g(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) causesNoChange p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) |
| pmid:26088141 | composite(a(CHEBI:choline), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") |
| pmid:26088141 | composite(a(CHEBI:choline), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") |
| pmid:26088141 | composite(a(CHEBI:choline), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) decreases a(CHEBI:"calcium(2+)") |
| pmid:26088141 | composite(a(CHEBI:choline), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) decreases a(CHEBI:"calcium(2+)") |
| pmid:26088141 | a(MESH:"GP Antagonist-2A peptide") causesNoChange a(CHEBI:"calcium(2+)") |
| pmid:26088141 | a(MESH:"GP Antagonist-2A peptide") causesNoChange act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) |
| pmid:26088141 | a(MESH:"GP Antagonist-2A peptide") decreases bp(MESH:"Pleckstrin Homology Domains") |
| pmid:26088141 | a(MESH:Barium) causesNoChange bp(GO:"calcium-mediated signaling") |
| pmid:26088141 | a(MESH:Barium) causesNoChange act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) |
| pmid:26088141 | a(MESH:Barium) causesNoChange act(p(HGNC:CHRNA7)) |
| pmid:26088141 | a(CHEBI:nifedipine) decreases act(a(CHEBI:choline)) |
| pmid:26088141 | a(CHEBI:nifedipine) decreases a(CHEBI:"calcium(2+)") |
| pmid:26088141 | a(CHEBI:nifedipine) increases bp(GO:"calcium-mediated signaling") |
| pmid:26088141 | a(CHEBI:nifedipine) causesNoChange bp(GO:"calcium-mediated signaling") |
| pmid:26088141 | a(CHEBI:nifedipine) causesNoChange act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) |
| pmid:26088141 | bp(MESH:"Pleckstrin Homology Domains") association a(CHEBI:choline) |
| pmid:26088141 | a(MESH:"xestospongin C") decreases act(p(HGNC:CHRNA7)) |
| pmid:26088141 | a(MESH:"xestospongin C") decreases bp(GO:"calcium-mediated signaling") |
| pmid:26088141 | a(MESH:"xestospongin C") decreases act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) |
| pmid:25514383 | a(MESH:"White Matter") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26195256 | a(MESH:"White Matter") association path(MESH:"Alzheimer Disease") |
| pmid:24762290 | a(MESH:"White Matter") positiveCorrelation complex(HBP:"alpha-4 beta-2 nAChR") |
| pmid:25514383 | a(HP:"cholinergic neuron") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25514383 | a(HP:"cholinergic neuron") association bp(GO:cognition) |
| pmid:25514383 | a(HP:"cholinergic neuron") increases bp(GO:cognition) |
| pmid:25514383 | a(HP:"cholinergic neuron") association path(MESH:Attention) |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"calcium ion transport") |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") positiveCorrelation bp(GO:"calcium ion transport") |
| pmid:28445721 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"calcium ion transport") |
| pmid:21482353 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) association bp(GO:"calcium ion transport") |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates tloc(a(CHEBI:neurotransmitter), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"second-messenger-mediated signaling") |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"neuron cellular homeostasis") |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"gene expression") |
| pmid:25514383 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases a(GO:"glutamatergic synapse") |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:25514383 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) regulates tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"positive regulation of synaptic plasticity") |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"positive regulation of synaptic plasticity") |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"intracellular signal transduction") |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases p(FPLX:AKT, pmod(Ph)) |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"ERK1 and ERK2 cascade") |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") decreases bp(HP:Neurodegeneration) |
| pmid:25514383 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases bp(HP:Neurodegeneration) |
| pmid:25514383 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases bp(MESH:"Cell Survival") |
| pmid:25514383 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases a(GO:synapse) |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases act(a(CHEBI:"pregnenolone sulfate")) |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:cognition) |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"synaptic transmission, glutamatergic") |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases act(a(CHEBI:simvastatin)) |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:memory) |
| pmid:25514383 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") decreases bp(GO:"apoptotic process") |
| pmid:28445721 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association bp(MESH:"Physiological Phenomena") |
| pmid:28445721 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association path(MESH:Disease) |
| pmid:21482353 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases act(p(MGI:Lynx1)) |
| pmid:21482353 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) association bp(GO:"generation of neurons") |
| pmid:21482353 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"sensory processing") |
| pmid:21482353 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"sensory processing") |
| pmid:21482353 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association a(HP:"inhibitory interneuron") |
| pmid:21482353 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases a(HP:"inhibitory interneuron") |
| pmid:21482353 | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association path(MESH:Schizophrenia) |
| pmid:28132910 | act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) negativeCorrelation a(HBP:"B-973") |
| pmid:25514383 | a(HBP:"alpha-7 beta-2 nAChR") negativeCorrelation act(a(CHEBI:"amyloid-beta")) |
| pmid:25514383 | complex(a(CHEBI:"amyloid-beta"), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) decreases bp(HP:Neurodegeneration) |
| pmid:25514383 | complex(a(CHEBI:"amyloid-beta"), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) decreases a(HBP:"amyloid-beta aggregates") |
| pmid:25514383 | p(HGNC:APP, frag("12_28")) increases complex(p(HGNC:APP, frag("12_28")), p(HGNC:CHRNA7)) |
| pmid:25514383 | complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) increases bp(GO:"intracellular signal transduction") |
| pmid:25514383 | complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) decreases bp(MESH:"Cell Survival") |
| pmid:25514383 | complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) association bp(GO:"neuron cellular homeostasis") |
| pmid:27522251 | complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) increases path(MESH:"Memory Disorders") |
| pmid:25514383 | a(PUBCHEM:637026) increases act(a(HBP:"beta-2-containing nAChR")) |
| pmid:25514383 | a(HBP:"amyloid-beta 40 oligomers") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:25514383 | composite(a(CHEBI:"amyloid-beta"), a(CHEBI:nicotine)) increases act(a(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:28420982 | bp(GO:"intracellular signal transduction") association p(HGNC:MAPT) |
| pmid:25514383 | a(HBP:"amyloid-beta 42 oligomers") increases bp(GO:"long-term synaptic potentiation") |
| pmid:28901280 | bp(MESH:"Cell Survival") association a(MESH:Acetylcholine) |
| pmid:30126037 | bp(MESH:"Cell Survival") association bp(GO:"cellular senescence") |
| pmid:30126037 | bp(HP:Neurodegeneration) association p(HGNC:CDKN2A) |
| pmid:28420982 | bp(HP:Neurodegeneration) decreases sec(p(HGNC:MAPT)) |
| pmid:25514383 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Val717Phe")) decreases path(MESH:"Spatial Memory") |
| pmid:28901280 | path(MESH:"Cognition Disorders") association p(MESH:"Receptors, Nicotinic") |
| pmid:25514383 | a(CHEBI:"(-)-cotinine") increases path(MESH:Attention) |
| pmid:25514383 | a(CHEBI:"(-)-cotinine") increases bp(GO:memory) |
| pmid:25514383 | a(CHEBI:"(-)-cotinine") decreases path(MESH:"Plaque, Amyloid") |
| pmid:25514383 | a(CHEBI:"(-)-cotinine") increases act(p(FPLX:AKT)) |
| pmid:25514383 | a(CHEBI:"(-)-cotinine") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:25514383 | a(HBP:"S 24795") decreases a(CHEBI:"amyloid-beta") |
| pmid:25514383 | a(HBP:"S 24795") increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:25514383 | bp(GO:"p38MAPK cascade") increases a(HBP:"Tau aggregates") |
| pmid:27314526 | bp(GO:"p38MAPK cascade") increases complex(GO:"neurofibrillary tangle") |
| pmid:25514383 | a(HBP:"4-OH-GTS-21") increases path(MESH:"Spatial Memory") |
| pmid:17640819 | a(HBP:"4-OH-GTS-21") increases path(MESH:"Spatial Memory") |
| pmid:25514383 | a(HBP:"4-OH-GTS-21") causesNoChange bp(GO:"neuron cellular homeostasis") |
| pmid:17640819 | a(HBP:"4-OH-GTS-21") increases path(MESH:"Avoidance Learning") |
| pmid:17640819 | a(HBP:"4-OH-GTS-21") causesNoChange bp(GO:locomotion) |
| pmid:17640819 | a(HBP:"4-OH-GTS-21") increases a(GO:perikaryon) |
| pmid:17640819 | a(HBP:"4-OH-GTS-21") causesNoChange a(MESH:"Cholinergic Neurons") |
| pmid:17640819 | a(HBP:"4-OH-GTS-21") decreases a(MESH:"Cholinergic Neurons") |
| pmid:17640819 | a(HBP:"4-OH-GTS-21") causesNoChange a(MESH:"GABAergic Neurons") |
| pmid:17640819 | a(HBP:"4-OH-GTS-21") causesNoChange a(CHEBI:"amyloid-beta") |
| pmid:25514383 | a(PUBCHEM:9928899) increases bp(GO:"long-term synaptic potentiation") |
| pmid:25514383 | a(CHEBI:"pregnenolone sulfate") increases bp(GO:cognition) |
| pmid:25514383 | a(CHEBI:"pregnenolone sulfate") increases bp(GO:"positive regulation of synaptic plasticity") |
| pmid:25514383 | a(CHEBI:"pregnenolone sulfate") increases bp(GO:"synaptic transmission, glutamatergic") |
| pmid:25514383 | a(CHEBI:"pregnenolone sulfate") increases path(MESH:"Spatial Memory") |
| pmid:25514383 | a(CHEBI:"pregnenolone sulfate") decreases bp(GO:"apoptotic process") |
| pmid:25514383 | a(CHEBI:simvastatin) regulates bp(GO:"cholesterol homeostasis") |
| pmid:25514383 | a(CHEBI:simvastatin) increases bp(GO:cognition) |
| pmid:25514383 | a(CHEBI:simvastatin) decreases bp(GO:"apoptotic process") |
| pmid:29626319 | a(CHEBI:simvastatin) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(CHEBI:simvastatin) increases bp(GO:"ERK1 and ERK2 cascade") |
| pmid:29626319 | a(CHEBI:simvastatin) increases sec(p(HGNC:MME)) |
| pmid:21718217 | bp(GO:"cholesterol homeostasis") association p(HGNC:NR1H3) |
| pmid:25514383 | composite(a(CHEBI:simvastatin), p(MGI:App, frag("25_35"))) increases bp(GO:memory) |
| pmid:25881725 | p(MGI:App, frag("25_35")) decreases bp(GO:learning) |
| pmid:25881725 | p(MGI:App, frag("25_35")) decreases path(MESH:"Spatial Memory") |
| pmid:25881725 | p(MGI:App, frag("25_35")) increases a(HBP:"amyloid-beta oligomers", loc(GO:"extracellular region")) |
| pmid:25881725 | p(MGI:App, frag("25_35")) causesNoChange r(MGI:Chrna7) |
| pmid:25514383 | complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN), p(HGNC:FLNA)) increases bp(GO:"intracellular signal transduction") |
| pmid:25514383 | complex(p(HGNC:CHRNA7), p(HGNC:FLNA)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25514383 | a(HBP:"PTI-125") decreases complex(p(HGNC:CHRNA7), p(HGNC:FLNA)) |
| pmid:25514383 | a(HBP:"PTI-125") decreases complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) |
| pmid:25514383 | a(HBP:"PTI-125") increases act(a(CHEBI:"amyloid-beta")) |
| pmid:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders") |
| pmid:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders") |
| pmid:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders") |
| pmid:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases bp(GO:locomotion) |
| pmid:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange path(MESH:Anxiety) |
| pmid:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange bp(GO:"microglial cell activation") |
| pmid:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange act(a(MESH:Neuroglia)) |
| pmid:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange bp(GO:"inflammatory response") |
| pmid:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(HBP:HBP00022) |
| pmid:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(HBP:HBP00022) |
| pmid:27522251 | p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(HBP:HBP00022) |
| pmid:27522251 | composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases path(MESH:"Memory Disorders") |
| pmid:27522251 | composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases path(MESH:"Memory Disorders") |
| pmid:27522251 | composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases a(HBP:HBP00022) |
| pmid:27522251 | complex(a(CHEBI:"amyloid-beta"), p(MGI:Chrnb2)) increases path(MESH:"Memory Disorders") |
| pmid:27522251 | composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases path(MESH:"Memory Disorders") |
| pmid:27522251 | composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases path(MESH:"Memory Disorders") |
| pmid:27522251 | composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases path(MESH:"Cognitive Dysfunction") |
| pmid:27522251 | composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases a(HBP:HBP00022) |
| pmid:24762290 | complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Thalamus) |
| pmid:24762290 | complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Thalamus) |
| pmid:24762290 | complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Pons) |
| pmid:24762290 | complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Mesencephalon) |
| pmid:24762290 | complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:"Corpus Striatum") |
| pmid:24762290 | complex(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"White Matter") |
| pmid:24762290 | complex(HBP:"alpha-4 beta-2 nAChR") association path(MESH:"Parkinson Disease") |
| pmid:24762290 | complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:"Parietal Lobe") |
| pmid:24762290 | complex(HBP:"alpha-4 beta-2 nAChR") association path(MESH:Memory) |
| pmid:24762290 | a(MESH:Pons) association complex(HBP:"alpha-4 beta-2 nAChR") |
| pmid:24762290 | a(MESH:Mesencephalon) association complex(HBP:"alpha-4 beta-2 nAChR") |
| pmid:24762290 | a(MESH:"Parietal Lobe") association complex(HBP:"alpha-4 beta-2 nAChR") |
| pmid:21718217 | a(HBP:HBP00089) association bp(GO:"microglial cell activation") |
| pmid:21718217 | a(HBP:HBP00089) positiveCorrelation bp(GO:"microglial cell activation") |
| pmid:21718217 | a(HBP:HBP00089) increases sec(p(HGNC:IFNG)) |
| pmid:21718217 | a(HBP:HBP00089) increases sec(p(HGNC:TNF)) |
| pmid:21718217 | a(HBP:HBP00089) increases sec(p(HGNC:IL1B)) |
| pmid:21718217 | a(HBP:HBP00089) increases sec(p(HGNC:IL6)) |
| pmid:21718217 | a(HBP:HBP00089) increases sec(p(HGNC:CCL2)) |
| pmid:23702978 | p(HGNC:IFNG) increases p(HGNC:AIM2) |
| pmid:23702978 | p(HGNC:IFNG) decreases act(p(HGNC:NLRP3)) |
| pmid:23702978 | p(HGNC:IFNG) increases act(p(HGNC:NOS2)) |
| pmid:23702978 | p(HGNC:IFNG) increases p(HGNC:CARD17) |
| pmid:23702978 | act(p(HGNC:IL1B)) increases bp(GO:"neutrophil activation") |
| pmid:24561250 | p(HGNC:IL1B) positiveCorrelation complex(GO:"inflammasome complex") |
| pmid:24561250 | p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27314526 | p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24561250 | p(HGNC:IL1B) increases bp(GO:"inflammatory response") |
| pmid:27314526 | p(HGNC:IL1B) positiveCorrelation path(MESH:Dementia) |
| pmid:27314526 | p(HGNC:IL1B) increases bp(GO:"microglial cell activation") |
| pmid:27314526 | p(HGNC:IL1B) increases bp(GO:"astrocyte activation") |
| pmid:27314526 | sec(p(HGNC:IL1B)) increases p(HGNC:APP) |
| pmid:27314526 | sec(p(HGNC:IL1B)) increases a(CHEBI:"amyloid-beta") |
| pmid:21718217 | act(p(HGNC:PPARG)) increases path(MESH:"Alzheimer Disease") |
| pmid:21718217 | act(p(HGNC:PPARG)) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:21718217 | act(p(HGNC:PPARG)) increases bp(GO:"reverse cholesterol transport") |
| pmid:21718217 | act(p(HGNC:PPARG)) decreases bp(GO:"microglial cell activation involved in immune response") |
| pmid:21718217 | p(HGNC:PPARG) association bp(MESH:"Energy Metabolism") |
| pmid:21718217 | p(HGNC:PPARG) increases bp(GO:"fat cell differentiation") |
| pmid:21718217 | p(HGNC:PPARG) association bp(GO:"response to insulin") |
| pmid:21718217 | p(HGNC:PPARG) association bp(GO:"lipid storage") |
| pmid:21718217 | p(HGNC:PPARG) increases p(HGNC:APOE) |
| pmid:21718217 | p(HGNC:PPARG) increases p(HGNC:ABCA1) |
| pmid:21718217 | p(HGNC:PPARG) increases p(HGNC:NR1H3) |
| pmid:21718217 | act(p(HGNC:PPARG)) increases p(HGNC:ARG1) |
| pmid:21718217 | act(p(HGNC:PPARG)) increases p(HGNC:IL4) |
| pmid:21718217 | act(p(HGNC:NR1H3)) increases path(MESH:"Alzheimer Disease") |
| pmid:21718217 | act(p(HGNC:NR1H3)) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:21718217 | act(p(HGNC:NR1H3)) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:21718217 | act(p(HGNC:NR1H3)) increases bp(GO:"reverse cholesterol transport") |
| pmid:21718217 | act(p(HGNC:NR1H3)) decreases bp(GO:"microglial cell activation involved in immune response") |
| pmid:21718217 | p(HGNC:NR1H3) association bp(GO:"cholesterol homeostasis") |
| pmid:21718217 | p(HGNC:NR1H3) association bp(GO:"negative regulation of inflammatory response") |
| pmid:21718217 | p(HGNC:NR1H3) increases p(HGNC:APOE) |
| pmid:21718217 | act(p(HGNC:NR1H3)) increases act(p(HGNC:APOE)) |
| pmid:21718217 | p(HGNC:NR1H3) increases p(HGNC:ABCA1) |
| pmid:21718217 | act(p(HGNC:NR1H3)) increases bp(GO:memory) |
| pmid:21718217 | act(p(HGNC:NR1H3)) decreases bp(GO:"microglial cell activation") |
| pmid:21718217 | p(FPLX:PPAR) association bp(MESH:"Energy Metabolism") |
| pmid:21718217 | p(FPLX:PPAR) positiveCorrelation bp(MESH:"Energy Metabolism") |
| pmid:21718217 | p(FPLX:PPAR) association bp(GO:"fat cell differentiation") |
| pmid:21718217 | p(FPLX:PPAR) positiveCorrelation bp(GO:"fat cell differentiation") |
| pmid:21718217 | p(FPLX:PPAR) association bp(GO:"response to insulin") |
| pmid:21718217 | p(FPLX:PPAR) positiveCorrelation bp(GO:"response to insulin") |
| pmid:21718217 | p(FPLX:PPAR) association bp(GO:"response to tumor cell") |
| pmid:21718217 | p(FPLX:PPAR) positiveCorrelation bp(GO:"response to tumor cell") |
| pmid:21718217 | p(FPLX:PPAR) regulates bp(GO:"lipid metabolic process") |
| pmid:21718217 | act(p(FPLX:PPAR)) decreases bp(GO:"microglial cell activation") |
| pmid:21718217 | act(p(FPLX:RXR)) increases p(HGNC:APOE) |
| pmid:21718217 | act(p(FPLX:RXR)) increases p(HGNC:ABCA1) |
| pmid:21718217 | bp(MESH:"Energy Metabolism") association p(FPLX:PPAR) |
| pmid:21718217 | bp(MESH:"Energy Metabolism") positiveCorrelation p(FPLX:PPAR) |
| pmid:21718217 | bp(MESH:"Energy Metabolism") association p(HGNC:PPARG) |
| pmid:21718217 | bp(MESH:"Energy Metabolism") association p(HGNC:PPARGC1A) |
| pmid:25784053 | bp(MESH:"Energy Metabolism") association p(HGNC:HSPD1) |
| pmid:21718217 | bp(GO:"fat cell differentiation") association p(FPLX:PPAR) |
| pmid:21718217 | bp(GO:"fat cell differentiation") positiveCorrelation p(FPLX:PPAR) |
| pmid:21718217 | bp(GO:"response to insulin") association p(FPLX:PPAR) |
| pmid:21718217 | bp(GO:"response to insulin") positiveCorrelation p(FPLX:PPAR) |
| pmid:21718217 | bp(GO:"response to insulin") association p(HGNC:PPARG) |
| pmid:21718217 | bp(GO:"response to tumor cell") association p(FPLX:PPAR) |
| pmid:21718217 | bp(GO:"response to tumor cell") positiveCorrelation p(FPLX:PPAR) |
| pmid:21718217 | p(HGNC:PPARA) regulates bp(GO:"lipid oxidation") |
| pmid:21718217 | p(HGNC:PPARA) regulates bp(MESH:"Lipid Peroxidation") |
| pmid:21718217 | bp(GO:"lipid storage") association p(HGNC:PPARG) |
| pmid:21718217 | p(HGNC:PPARD) association bp(GO:"fatty acid oxidation") |
| pmid:21718217 | act(p(HGNC:PPARD)) increases bp(GO:"reverse cholesterol transport") |
| pmid:21718217 | act(p(HGNC:PPARD)) increases bp(GO:"negative regulation of inflammatory response") |
| pmid:21718217 | act(p(HGNC:PPARD)) increases p(HGNC:ARG1) |
| pmid:21718217 | act(p(HGNC:PPARD)) increases p(HGNC:IL4) |
| pmid:21718217 | bp(GO:"fatty acid oxidation") association p(HGNC:PPARD) |
| pmid:21718217 | a(CHEBI:oxysterol) increases act(p(HGNC:NR1H3)) |
| pmid:21718217 | a(CHEBI:oxysterol) increases act(p(HGNC:NR1H3)) |
| pmid:21718217 | bp(GO:"negative regulation of inflammatory response") association p(HGNC:NR1H3) |
| pmid:21718217 | a(HBP:HBP00030) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:30116051 | a(HBP:HBP00030) increases path(MESH:"Alzheimer Disease") |
| pmid:21718217 | a(HBP:HBP00030) increases a(HBP:HBP00018) |
| pmid:30116051 | a(HBP:HBP00030) increases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:30116051 | a(HBP:HBP00030) increases p(HGNC:LGMN) |
| pmid:21718217 | p(HGNC:ABCA1) increases p(HGNC:APOE) |
| pmid:21718217 | p(HGNC:ABCA1) decreases a(HBP:HBP00018) |
| pmid:21718217 | p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:30116051 | p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:26195256 | p(HGNC:IDE) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) |
| pmid:29626319 | p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:28019679 | p(HGNC:IDE) decreases a(CHEBI:"amyloid-beta") |
| pmid:30116051 | p(HGNC:IDE) increases deg(p(HGNC:IAPP)) |
| pmid:30116051 | p(HGNC:IDE) decreases a(HBP:HBP00016) |
| pmid:30116051 | p(HGNC:IDE) decreases a(HBP:HBP00018) |
| pmid:30116051 | p(HGNC:IDE) decreases a(HBP:HBP00092) |
| pmid:29626319 | p(HGNC:IDE) negativeCorrelation bp(GO:aging) |
| pmid:29626319 | p(HGNC:IDE) negativeCorrelation path(MESH:"Diabetes Mellitus") |
| pmid:28019679 | p(HGNC:IDE) regulates complex(GO:"NLRP3 inflammasome complex") |
| pmid:21718217 | a(CHEBI:"GW 3965") directlyIncreases act(p(HGNC:NR1H3)) |
| pmid:21718217 | a(CHEBI:"GW 3965") increases act(p(HGNC:NR1H3)) |
| pmid:21718217 | a(CHEBI:"GW 3965") increases p(HGNC:APOE) |
| pmid:21718217 | a(CHEBI:"GW 3965") increases p(HGNC:ABCA1) |
| pmid:21718217 | a(CHEBI:"GW 3965") decreases a(HBP:HBP00018) |
| pmid:21718217 | a(CHEBI:"GW 3965") increases bp(GO:memory) |
| pmid:21718217 | a(CHEBI:"GW 3965") decreases path(MESH:Inflammation) |
| pmid:21718217 | a(CHEBI:"GW 3965") increases act(a(HBP:HBP00038)) |
| pmid:21718217 | a(CHEBI:"GW 3965") increases bp(GO:phagocytosis) |
| pmid:21718217 | p(MGI:Abca1) decreases a(CHEBI:"amyloid-beta") |
| pmid:21718217 | p(MGI:Abca1) decreases a(HBP:HBP00038) |
| pmid:21718217 | a(CHEBI:pioglitazone) increases act(p(HGNC:PPARG)) |
| pmid:21718217 | a(CHEBI:pioglitazone) decreases path(MESH:"Diabetes Mellitus, Type 2") |
| pmid:21718217 | a(CHEBI:pioglitazone) decreases a(HBP:HBP00018) |
| pmid:21718217 | a(CHEBI:pioglitazone) decreases a(HBP:HBP00018) |
| pmid:21718217 | a(CHEBI:pioglitazone) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:21718217 | a(CHEBI:pioglitazone) increases bp(GO:behavior) |
| pmid:21718217 | a(CHEBI:pioglitazone) increases p(MGI:Abca1) |
| pmid:21718217 | a(CHEBI:pioglitazone) increases p(MGI:Apoe) |
| pmid:21718217 | a(CHEBI:pioglitazone) increases bp(GO:memory) |
| pmid:21718217 | a(CHEBI:pioglitazone) increases bp(GO:cognition) |
| pmid:29626319 | a(CHEBI:pioglitazone) decreases a(CHEBI:"amyloid-beta") |
| pmid:21718217 | a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG)) |
| pmid:21718217 | a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG)) |
| pmid:29626319 | a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG)) |
| pmid:21718217 | a(CHEBI:rosiglitazone) decreases path(MESH:"Diabetes Mellitus, Type 2") |
| pmid:21718217 | a(CHEBI:rosiglitazone) increases bp(GO:behavior) |
| pmid:21718217 | a(CHEBI:rosiglitazone) causesNoChange a(HBP:HBP00018) |
| pmid:21718217 | a(CHEBI:rosiglitazone) decreases a(HBP:HBP00018) |
| pmid:21718217 | a(CHEBI:rosiglitazone) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:21718217 | a(CHEBI:rosiglitazone) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(CHEBI:rosiglitazone) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:21718217 | a(CHEBI:rosiglitazone) increases bp(GO:"learning or memory") |
| pmid:21718217 | a(CHEBI:rosiglitazone) increases p(MGI:Ctnnb1) |
| pmid:21718217 | a(CHEBI:rosiglitazone) decreases p(MGI:Gsk3b) |
| pmid:21718217 | a(CHEBI:rosiglitazone) increases p(MGI:Abca1) |
| pmid:21718217 | a(CHEBI:rosiglitazone) increases bp(GO:memory) |
| pmid:21718217 | a(CHEBI:rosiglitazone) increases bp(GO:cognition) |
| pmid:29626319 | a(CHEBI:rosiglitazone) increases act(a(MESH:Microglia)) |
| pmid:19732809 | path(MESH:"Diabetes Mellitus, Type 2") negativeCorrelation a(HBP:"O-GlcNAcylation") |
| pmid:22798221 | act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 404)) |
| pmid:22798221 | act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 198)) |
| pmid:22798221 | act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 199)) |
| pmid:22798221 | act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 202)) |
| pmid:22798221 | act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 231)) |
| pmid:22798221 | act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 396)) |
| pmid:22798221 | act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 205)) |
| pmid:21718217 | a(CHEBI:"GW 501516") increases act(p(HGNC:PPARD)) |
| pmid:21718217 | a(CHEBI:"GW 501516") increases p(HGNC:ABCA1) |
| pmid:21718217 | a(CHEBI:"GW 501516") increases p(HGNC:APOA1) |
| pmid:21718217 | a(CHEBI:"GW 501516") decreases a(HBP:HBP00018) |
| pmid:21718217 | a(CHEBI:"GW 501516") increases p(HGNC:MME) |
| pmid:21718217 | a(CHEBI:"GW 501516") increases p(HGNC:IDE) |
| pmid:21718217 | a(CHEBI:"all-trans-retinoic acid") increases act(p(FPLX:RXR)) |
| pmid:21718217 | a(CHEBI:"all-trans-retinoic acid") increases act(p(FPLX:RAR)) |
| pmid:21718217 | a(CHEBI:"all-trans-retinoic acid") decreases a(HBP:HBP00018) |
| pmid:21718217 | a(CHEBI:"all-trans-retinoic acid") decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:21718217 | a(CHEBI:"all-trans-retinoic acid") increases bp(GO:memory) |
| pmid:26400044 | a(CHEBI:"all-trans-retinoic acid") decreases path(MESH:"Plaque, Amyloid") |
| pmid:26400044 | a(CHEBI:"all-trans-retinoic acid") decreases a(HBP:"APP processing") |
| pmid:26400044 | a(CHEBI:"all-trans-retinoic acid") decreases act(p(MGI:Cdk5), ma(kin)) |
| pmid:26400044 | a(CHEBI:"all-trans-retinoic acid") decreases act(p(MGI:Gsk3b), ma(kin)) |
| pmid:26400044 | a(CHEBI:"all-trans-retinoic acid") decreases complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) |
| pmid:21718217 | a(CHEBI:bexarotene) increases act(p(FPLX:RXR)) |
| pmid:21718217 | a(CHEBI:bexarotene) increases p(HGNC:APOE) |
| pmid:21718217 | a(CHEBI:bexarotene) increases p(HGNC:ABCA1) |
| pmid:21718217 | a(CHEBI:bexarotene) decreases a(HBP:HBP00018) |
| pmid:21718217 | a(CHEBI:bexarotene) increases bp(GO:behavior) |
| pmid:21718217 | a(CHEBI:Honokiol) increases act(p(FPLX:RXR)) |
| pmid:21718217 | a(CHEBI:Honokiol) increases act(complex(p(FPLX:RXR), p(HGNC:NR1H3))) |
| pmid:21718217 | a(CHEBI:Honokiol) increases p(HGNC:APOE) |
| pmid:21718217 | a(CHEBI:Honokiol) increases p(HGNC:ABCA1) |
| pmid:21718217 | r(HGNC:ARG1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21718217 | r(HGNC:CHI3L1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:11230871 | bp(MESH:"Lipid Peroxidation") decreases p(FPLX:CHRN) |
| pmid:21718217 | p(HGNC:PPARGC1A) association bp(MESH:"Energy Metabolism") |
| pmid:21718217 | p(HGNC:PPARGC1A) association path(MESH:"Insulin Resistance") |
| pmid:21718217 | p(HGNC:PPARGC1A) increases bp(GO:"fat cell differentiation") |
| pmid:21718217 | a(CHEBI:cholesterol) increases act(p(HGNC:NR1H3)) |
| pmid:19721446 | a(CHEBI:cholesterol) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:21718217 | p(HBP:HBP00030) association path(MESH:"Alzheimer Disease") |
| pmid:21718217 | p(HGNC:IL10) decreases a(MESH:Macrophages) |
| pmid:21718217 | a(MESH:Glucocorticoids) decreases a(MESH:Macrophages) |
| pmid:21718217 | p(HGNC:TGFB1) decreases a(MESH:Macrophages) |
| pmid:26304819 | p(HGNC:TGFB1) biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:28445721 | path(MESH:Motivation) association p(FPLX:CHRN) |
| pmid:28445721 | bp(MESH:"Physiological Phenomena") association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:28445721 | path(MESH:Disease) association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:28445721 | p(HGNC:RIC3) increases act(p(FPLX:CHRN)) |
| pmid:28445721 | p(HGNC:RIC3) increases act(p(FPLX:CHRN)) |
| pmid:28445721 | p(HGNC:RIC3) increases act(p(FPLX:CHRN)) |
| pmid:22040696 | act(p(HGNC:RIC3), ma(chap)) increases p(FPLX:CHRN) |
| pmid:22040696 | p(HGNC:RIC3) increases act(p(FPLX:CHRN)) |
| pmid:22040696 | act(p(HGNC:RIC3), ma(chap)) increases p(FPLX:CHRN) |
| pmid:28445721 | p(HGNC:RIC3) causesNoChange complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta2")) |
| pmid:28445721 | p(HGNC:RIC3) causesNoChange complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28445721 | p(HGNC:RIC3) increases surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:22040696 | p(HGNC:RIC3) increases bp(GO:"synaptic transmission, cholinergic") |
| pmid:22040696 | p(HGNC:RIC3) decreases act(complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4))) |
| pmid:22040696 | p(HGNC:RIC3) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) |
| pmid:22040696 | p(HGNC:RIC3) increases p(HGNC:CHRNA9) |
| pmid:22040696 | p(HGNC:RIC3) increases p(HGNC:CHRNA7) |
| pmid:22040696 | act(p(HGNC:RIC3), ma(chap)) negativeCorrelation path(MESH:"Bipolar Disorder") |
| pmid:22040696 | act(p(HGNC:RIC3), ma(chap)) negativeCorrelation path(MESH:"Psychotic Disorders") |
| pmid:28445721 | p(HGNC:TMEM35A) regulates act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) regulates surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) regulates a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28445721 | p(HGNC:TMEM35A) causesNoChange act(p(FPLX:GABR)) |
| pmid:28445721 | p(HGNC:TMEM35A) causesNoChange act(a(MESH:"Receptors, Serotonin")) |
| pmid:28445721 | p(HGNC:TMEM35A) causesNoChange act(p(HGNC:TRPV1)) |
| pmid:28445721 | p(HGNC:TMEM35A) causesNoChange act(a(MESH:"Receptors, Glutamate")) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases act(a(HBP:HBP00174)) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(HBP:HBP00174)) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases a(HBP:HBP00174) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases act(a(MESH:"nicotinic receptor alpha3beta2")) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(MESH:"nicotinic receptor alpha3beta2")) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases a(MESH:"nicotinic receptor alpha3beta2") |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases act(a(MESH:"nicotinic receptor alpha3beta4")) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(MESH:"nicotinic receptor alpha3beta4")) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases a(MESH:"nicotinic receptor alpha3beta4") |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta2")) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(HBP:HBP00174)) |
| pmid:28445721 | act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta4")) |
| pmid:28445721 | p(HGNC:TMEM35A) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) |
| pmid:28445721 | p(HGNC:TMEM35A) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) |
| pmid:28445721 | p(HGNC:TMEM35A) increases a(MESH:"alpha6beta2 nicotinic acetylcholine receptor") |
| pmid:28445721 | act(p(MGI:Tmem35a), ma(chap)) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:28445721 | p(MGI:Tmem35a) association p(MGI:Canx) |
| pmid:28445721 | p(MGI:Tmem35a) increases complex(a(MESH:Bungarotoxins), p(FPLX:CHRN)) |
| pmid:28445721 | p(MGI:Tmem35a) increases complex(a(CHEBI:epibatidine), a(HBP:HBP00180)) |
| pmid:28445721 | p(MGI:Tmem35a) increases complex(a(CHEBI:epibatidine), a(HBP:HBP00174)) |
| pmid:28445721 | p(MGI:Tmem35a) increases a(HBP:HBP00180) |
| pmid:28445721 | p(MGI:Tmem35a) increases complex(a(GO:membrane), a(MESH:Bungarotoxins)) |
| pmid:28445721 | p(MGI:Tmem35a) increases p(FPLX:CHRN) |
| pmid:28445721 | p(MGI:Tmem35a) regulates p(FPLX:CHRN) |
| pmid:28445721 | p(MGI:Tmem35a) increases a(MESH:"nicotinic receptor alpha3beta4") |
| pmid:28445721 | p(MGI:Tmem35a) decreases bp(GO:locomotion) |
| pmid:28445721 | p(MGI:Tmem35a) decreases bp(GO:locomotion) |
| pmid:28445721 | p(MGI:Tmem35a) association bp(GO:"temperature homeostasis") |
| pmid:28445721 | p(MGI:Tmem35a) increases bp(GO:learning) |
| pmid:28445721 | p(MGI:Tmem35a) increases bp(GO:memory) |
| pmid:28445721 | p(MGI:Tmem35a) increases path(MESH:"Spatial Learning") |
| pmid:28445721 | p(MGI:Tmem35a) increases path(MESH:"Spatial Memory") |
| pmid:11230871 | complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) negativeCorrelation bp(GO:aging) |
| pmid:11230871 | complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) negativeCorrelation bp(GO:aging) |
| pmid:28445721 | p(MGI:Canx) association p(MGI:Tmem35a) |
| pmid:18174175 | complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) increases act(a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) |
| pmid:21787755 | a(MESH:"alpha6beta2 nicotinic acetylcholine receptor") regulates sec(a(CHEBI:"gamma-aminobutyric acid")) |
| pmid:28445721 | a(MESH:"alpha-conotoxin MII") decreases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) |
| pmid:21787755 | a(MESH:"alpha-conotoxin MII") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) |
| pmid:28445721 | bp(GO:"temperature homeostasis") association p(MGI:Tmem35a) |
| pmid:21482353 | a(MESH:"Presynaptic Terminals") increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:27671637 | a(MESH:"Presynaptic Terminals") causesNoChange p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:21482353 | p(HGNC:CHRNA4, var("?")) positiveCorrelation path(MESH:Epilepsy) |
| pmid:21482353 | p(HGNC:CHRNA4, var("?")) increases path(HBP:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") |
| pmid:21482353 | p(HGNC:CHRNB2, var("?")) positiveCorrelation path(MESH:Epilepsy) |
| pmid:21482353 | p(HGNC:CHRNB2, var("?")) increases path(HBP:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") |
| pmid:21482353 | p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") |
| pmid:21482353 | p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") |
| pmid:21482353 | p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:Alcoholism) |
| pmid:21482353 | p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Cocaine-Related Disorders") |
| pmid:21482353 | p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Opioid-Related Disorders") |
| pmid:21482353 | p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms") |
| pmid:21482353 | p(HGNC:CHRNA5, var("?")) positiveCorrelation bp(GO:cognition) |
| pmid:21482353 | complex(p(FPLX:CHRN), p(HGNC:RIC3)) increases p(FPLX:CHRN) |
| pmid:21482353 | complex(p(FPLX:CHRN), p(HGNC:RIC3)) increases act(p(FPLX:CHRN)) |
| pmid:21482353 | complex(a(INTERPRO:"14-3-3 protein"), p(FPLX:CHRN)) increases p(FPLX:CHRN) |
| pmid:21482353 | complex(a(INTERPRO:"14-3-3 protein"), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) |
| pmid:21482353 | complex(p(FPLX:CHRN), p(INTERPRO:Neurexin)) increases p(FPLX:CHRN) |
| pmid:21482353 | complex(p(FPLX:CHRN), p(INTERPRO:Neurexin)) increases act(p(FPLX:CHRN)) |
| pmid:21482353 | complex(p(FPLX:CHRN), p(HGNC:VSNL1)) increases p(FPLX:CHRN) |
| pmid:21482353 | complex(p(FPLX:CHRN), p(HGNC:VSNL1)) increases act(p(FPLX:CHRN)) |
| pmid:19721446 | p(HGNC:VSNL1) association p(HGNC:CHRNA4, frag("331_600")) |
| pmid:21482353 | complex(p(FPLX:CHRN), p(HGNC:LYNX1)) regulates act(p(FPLX:CHRN)) |
| pmid:21482353 | complex(p(FPLX:CHRN), p(HGNC:LYNX1)) association act(p(FPLX:CHRN)) |
| pmid:21482353 | complex(p(FPLX:CHRN), p(HGNC:LYNX1)) association surf(p(FPLX:CHRN)) |
| pmid:21482353 | p(HGNC:LYNX1) regulates act(p(FPLX:CHRN)) |
| pmid:21482353 | p(HGNC:LYNX1) decreases act(p(FPLX:CHRN)) |
| pmid:21482353 | p(HGNC:LYNX1) decreases act(p(FPLX:CHRN)) |
| pmid:21482353 | p(HGNC:LYNX1) regulates act(p(FPLX:CHRN)) |
| pmid:21482353 | p(HGNC:LYNX1) decreases bp(GO:"synaptic transmission, cholinergic") |
| pmid:21482353 | p(HGNC:LYNX1) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:21482353 | p(HGNC:LYNX1) association path(MESH:"Cognitive Dysfunction") |
| pmid:21482353 | p(HGNC:LYNX1) positiveCorrelation bp(GO:"neuron maturation") |
| pmid:21482353 | p(HGNC:LYNX1) negativeCorrelation bp(GO:"synapse maturation") |
| pmid:21482353 | p(HGNC:LYNX1) regulates bp(GO:"generation of neurons") |
| pmid:28901280 | p(HGNC:LYNX1) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) |
| pmid:28901280 | p(HGNC:LYNX1) decreases act(p(HGNC:CHRNA7)) |
| pmid:21482353 | composite(a(HBP:"alpha-4 beta-2 nAChR"), p(HGNC:LYNX1)) decreases act(p(FPLX:CHRN)) |
| pmid:21482353 | complex(a(HBP:"alpha-4 beta-2 nAChR"), p(HGNC:LYNX1)) regulates act(a(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:21482353 | complex(p(HGNC:CHRNA3), p(HGNC:LYNX1)) regulates act(p(HGNC:CHRNA3)) |
| pmid:21482353 | complex(a(HBP:"alpha-7-containing nAChR"), p(HGNC:LYNX1)) regulates act(a(HBP:"alpha-7-containing nAChR")) |
| pmid:21482353 | a(HBP:"alpha-7-containing nAChR") increases p(HGNC:SLC12A5) |
| pmid:21482353 | a(HBP:"alpha-7-containing nAChR") increases p(HGNC:SLC12A5) |
| pmid:21482353 | a(HBP:"alpha-7-containing nAChR") association bp(GO:"macrophage activation") |
| pmid:21482353 | a(HBP:"alpha-7-containing nAChR") association bp(GO:"response to cytokine") |
| pmid:11230871 | a(HBP:"alpha-7-containing nAChR") negativeCorrelation bp(GO:aging) |
| pmid:11230871 | a(HBP:"alpha-7-containing nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:11230871 | a(HBP:"alpha-7-containing nAChR") negativeCorrelation path(MESH:Schizophrenia) |
| pmid:11230871 | a(HBP:"alpha-7-containing nAChR") regulates act(a(CHEBI:"amyloid-beta")) |
| pmid:21787755 | a(HBP:"alpha-7-containing nAChR") decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:21787755 | a(HBP:"alpha-7-containing nAChR") regulates bp(GO:"excitatory chemical synaptic transmission") |
| pmid:21787755 | a(HBP:"alpha-7-containing nAChR") association bp(GO:"neurotransmitter secretion") |
| pmid:21787755 | a(HBP:"alpha-7-containing nAChR") association bp(GO:"maintenance of synapse structure") |
| pmid:21787755 | a(HBP:"alpha-7-containing nAChR") association bp(GO:"neuron projection maintenance") |
| pmid:21787755 | a(HBP:"alpha-7-containing nAChR") association bp(GO:"long-term synaptic potentiation") |
| pmid:21787755 | a(HBP:"alpha-7-containing nAChR") association path(MESH:Seizures) |
| pmid:21787755 | a(HBP:"alpha-7-containing nAChR") association bp(GO:"neuron death") |
| pmid:21482353 | p(MGI:Lynx1) decreases a(CHEBI:"calcium(2+)") |
| pmid:21482353 | p(MGI:Lynx1) decreases bp(MESH:"Synaptic Transmission") |
| pmid:21482353 | p(MGI:Lynx1) decreases bp(GO:learning) |
| pmid:21482353 | p(MGI:Lynx1) decreases bp(GO:memory) |
| pmid:21482353 | p(MGI:Lynx1) decreases bp(MESH:"Dominance, Ocular") |
| pmid:21482353 | p(MGI:Lynx1) decreases bp(GO:"synaptic transmission, cholinergic") |
| pmid:21482353 | p(MGI:Lynx1) increases a(MESH:Neurons) |
| pmid:21482353 | act(a(MESH:Brain)) negativeCorrelation act(p(FPLX:CHRN)) |
| pmid:24027553 | a(MESH:Brain) association act(p(HGNC:NPEPPS)) |
| pmid:21482353 | p(MGI:Slc12a2) increases act(p(MGI:Lynx1)) |
| pmid:21482353 | p(FPLX:ADCY, var("?")) decreases act(p(MGI:Lynx1)) |
| pmid:21482353 | p(HGNC:PSCA) decreases bp(GO:"programmed cell death") |
| pmid:21482353 | bp(GO:"neuron maturation") positiveCorrelation p(HGNC:LYNX1) |
| pmid:21482353 | bp(GO:"synapse maturation") negativeCorrelation p(HGNC:LYNX1) |
| pmid:21482353 | bp(GO:"generation of neurons") association act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:21482353 | bp(GO:"GABAergic neuron differentiation") association path(MESH:Schizophrenia) |
| pmid:21482353 | bp(GO:"GABAergic neuron differentiation") association path(MESH:Amblyopia) |
| pmid:21482353 | path(MESH:Amblyopia) association bp(GO:"GABAergic neuron differentiation") |
| pmid:21482353 | a(HP:"inhibitory interneuron") regulates bp(GO:"sensory processing") |
| pmid:21482353 | act(a(HP:"inhibitory interneuron")) increases act(p(FPLX:NOS)) |
| pmid:21482353 | a(HP:"inhibitory interneuron") association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:21482353 | act(a(HP:"inhibitory interneuron")) negativeCorrelation g(HGNC:CHRFAM7A, var("?")) |
| pmid:21482353 | a(MESH:"Brain Stem") regulates act(a(MESH:Hippocampus)) |
| pmid:21482353 | g(HGNC:CHRFAM7A, var("?")) association path(MESH:Schizophrenia) |
| pmid:21482353 | g(HGNC:CHRFAM7A, var("?")) negativeCorrelation act(a(HP:"inhibitory interneuron")) |
| pmid:21482353 | g(HGNC:NRG1) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| pmid:21482353 | a(HBP:"GTS-21") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:21482353 | a(HBP:"GTS-21") increases path(MESH:Attention) |
| pmid:21482353 | a(HBP:"GTS-21") increases bp(GO:"sensory processing") |
| pmid:21482353 | a(HBP:"GTS-21") decreases path(MESH:Anhedonia) |
| pmid:21482353 | a(HBP:"GTS-21") decreases path(MESH:Aphasia) |
| pmid:21482353 | p(HGNC:SLC12A5) decreases a(CHEBI:chloride) |
| pmid:21482353 | p(HGNC:SLC12A5) regulates act(a(CHEBI:"gamma-aminobutyric acid")) |
| pmid:21482353 | p(HGNC:PEMT) increases a(CHEBI:phosphatidylcholine) |
| pmid:21482353 | a(CHEBI:phosphatidylcholine) increases a(CHEBI:choline) |
| pmid:21482353 | p(HGNC:PEMT, var("?")) association path(MESH:"Choline Deficiency") |
| pmid:21482353 | p(HGNC:PEMT, var("?")) association path(MESH:Schizophrenia) |
| pmid:21482353 | path(MESH:"Choline Deficiency") association p(HGNC:PEMT, var("?")) |
| pmid:21482353 | bp(GO:"macrophage activation") association a(HBP:"alpha-7-containing nAChR") |
| pmid:21482353 | bp(GO:"response to cytokine") association a(HBP:"alpha-7-containing nAChR") |
| pmid:21482353 | bp(MESH:"Stress, Physiological") increases a(CHEBI:dopamine) |
| pmid:25784053 | bp(MESH:"Stress, Physiological") regulates bp(HBP:Proteostasis) |
| pmid:21482353 | path(MESH:Fear) increases a(CHEBI:dopamine) |
| pmid:21482353 | path(MESH:Alcoholism) positiveCorrelation p(HGNC:CHRNA5, var("?")) |
| pmid:21482353 | path(MESH:Alcoholism) positiveCorrelation p(HGNC:CHRNA3, var("?")) |
| pmid:21482353 | path(MESH:Alcoholism) positiveCorrelation p(HGNC:CHRNB4, var("?")) |
| pmid:21482353 | path(MESH:"Cocaine-Related Disorders") positiveCorrelation p(HGNC:CHRNA5, var("?")) |
| pmid:21482353 | path(MESH:"Cocaine-Related Disorders") positiveCorrelation p(HGNC:CHRNA3, var("?")) |
| pmid:21482353 | path(MESH:"Cocaine-Related Disorders") positiveCorrelation p(HGNC:CHRNB4, var("?")) |
| pmid:21482353 | path(MESH:"Opioid-Related Disorders") positiveCorrelation p(HGNC:CHRNA5, var("?")) |
| pmid:21482353 | path(MESH:"Opioid-Related Disorders") positiveCorrelation p(HGNC:CHRNA3, var("?")) |
| pmid:21482353 | path(MESH:"Opioid-Related Disorders") positiveCorrelation p(HGNC:CHRNB4, var("?")) |
| pmid:21482353 | path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNA5, var("?")) |
| pmid:21482353 | path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNA3, var("?")) |
| pmid:21482353 | path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNB4, var("?")) |
| pmid:19721446 | path(MESH:"Lung Neoplasms") association g(HGNC:CHRNA5) |
| pmid:19721446 | path(MESH:"Lung Neoplasms") association g(HGNC:CHRNA3) |
| pmid:19721446 | path(MESH:"Lung Neoplasms") association g(HGNC:CHRNB4) |
| pmid:28901280 | path(MESH:"Lung Neoplasms") association g(DNSNP:rs1051730) |
| pmid:28901280 | path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA9) |
| pmid:28901280 | path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA5) |
| pmid:28901280 | path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA10) |
| pmid:21482353 | p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") |
| pmid:21482353 | p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:Alcoholism) |
| pmid:21482353 | p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Cocaine-Related Disorders") |
| pmid:21482353 | p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Opioid-Related Disorders") |
| pmid:21482353 | p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms") |
| pmid:21482353 | p(HGNC:CHRNA3, var("?")) positiveCorrelation bp(GO:cognition) |
| pmid:21482353 | p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") |
| pmid:21482353 | p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:Alcoholism) |
| pmid:21482353 | p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Cocaine-Related Disorders") |
| pmid:21482353 | p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Opioid-Related Disorders") |
| pmid:21482353 | p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms") |
| pmid:21482353 | p(HGNC:CHRNB4, var("?")) positiveCorrelation bp(GO:cognition) |
| pmid:21482353 | path(MESH:"Tobacco Use") decreases path(MESH:"Parkinson Disease") |
| pmid:18986241 | path(MESH:D019636) association path(MESH:D000544) |
| pmid:18986241 | path(MESH:D001526) association path(MESH:D000544) |
| pmid:18986241 | path(HBP:aMCI) association path(MESH:D008569) |
| pmid:18986241 | path(HBP:aMCI) association path(MESH:D003704) |
| pmid:18986241 | path(HBP:aMCI) association path(MESH:D000544) |
| pmid:18986241 | path(MESH:D008569) association path(HBP:aMCI) |
| pmid:18986241 | path(HBP:mdMCI) association path(MESH:D060825) |
| pmid:18986241 | path(MESH:D060825) association path(HBP:mdMCI) |
| pmid:18986241 | path(MESH:D060825) association path(MESH:D062706) |
| pmid:18986241 | path(MESH:D060825) association bp(HBP:Neurodegeneration) |
| pmid:18986241 | path(MESH:D060825) causesNoChange act(p(HGNC:CHAT)) |
| pmid:18986241 | path(MESH:D060825) increases act(p(HGNC:CHAT)) |
| pmid:18986241 | path(MESH:D060825) increases act(p(HGNC:CHAT)) |
| pmid:18986241 | path(MESH:D060825) decreases a(MESH:D013569) |
| pmid:18986241 | path(MESH:D060825) increases a(MESHC:"pro-nerve growth factor, human") |
| pmid:18986241 | path(MESH:D060825) increases act(p(HGNC:MMP9)) |
| pmid:18986241 | path(MESH:D060825) causesNoChange r(HGNC:CHAT) |
| pmid:18986241 | path(MESH:D060825) association p(HGNC:CHRM1) |
| pmid:18986241 | path(MESH:D060825) decreases a(HBP:"3R tau") |
| pmid:18986241 | path(MESH:D062706) association path(MESH:D060825) |
| pmid:18986241 | a(MESH:D059329) directlyIncreases bp(GO:"GO:0060384") |
| pmid:18986241 | a(MESH:D059329) association path(MESH:D008568) |
| pmid:18986241 | a(MESH:D059329) association path(MESH:D001288) |
| pmid:18986241 | a(MESH:D059329) association a(MESH:D016874) |
| pmid:18986241 | a(MESH:D059329) association path(MESH:D000544) |
| pmid:18986241 | a(MESH:D059329) association a(MESH:D009479) |
| pmid:18986241 | a(MESH:D059329) association a(MESH:D059330) |
| pmid:18986241 | a(MESH:D059329) association p(RGD:Gal) |
| pmid:18986241 | a(MESH:D059329) association path(MESH:D008570) |
| pmid:18986241 | a(MESH:D059329) association path(MESH:D003704) |
| pmid:18986241 | bp(GO:"GO:0060384") association p(HGNC:NGF) |
| pmid:18986241 | path(MESH:D001288) association a(MESH:D059329) |
| pmid:18986241 | a(MESH:D016874) association a(MESH:D059329) |
| pmid:18986241 | a(MESH:D016874) association path(MESH:D000544) |
| pmid:18986241 | a(MESH:D016874) association p(HGNC:BCHE) |
| pmid:18986241 | a(MESH:D009479) association a(MESH:D059329) |
| pmid:18986241 | a(MESH:D059330) association a(MESH:D059329) |
| pmid:18986241 | p(RGD:Gal) association a(MESH:D059329) |
| pmid:18986241 | path(MESH:D008570) association a(MESH:D059329) |
| pmid:18986241 | a(MESH:D005625) positiveCorrelation path(MESH:D011597) |
| pmid:18986241 | path(MESH:D011597) positiveCorrelation a(MESH:D005625) |
| pmid:18986241 | p(HGNC:BCHE, var("p.Ala539Thr")) decreases p(HGNC:BCHE) |
| pmid:18986241 | complex(p(HGNC:NGF), p(HGNC:NTRK1)) increases bp(GO:"GO:0038180") |
| pmid:18986241 | complex(p(HGNC:NGF), p(HGNC:NTRK1)) increases bp(GO:"GO:0031175") |
| pmid:18986241 | p(HGNC:NTRK1) negativeCorrelation path(MESH:D003072) |
| pmid:18986241 | p(HGNC:NTRK1) biomarkerFor path(MESH:D000544) |
| pmid:18986241 | p(HGNC:NTRK1) decreases act(p(HGNC:BACE1)) |
| pmid:18986241 | bp(GO:"GO:0038180") increases bp(GO:"GO:1990089") |
| pmid:18986241 | complex(p(HGNC:NGF), p(HGNC:NGFR)) increases complex(p(HGNC:NGF), p(HGNC:NTRK1)) |
| pmid:18986241 | bp(GO:"GO:1901214") association p(HGNC:NGFR) |
| pmid:18986241 | a(MESHC:"pro-nerve growth factor, human") positiveCorrelation path(MESH:D003072) |
| pmid:18986241 | a(MESHC:"pro-nerve growth factor, human") biomarkerFor path(MESH:D000544) |
| pmid:18986241 | complex(a(MESHC:"pro-nerve growth factor, human"), p(HGNC:NTRK1)) increases bp(GO:"GO:0031175") |
| pmid:18986241 | bp(GO:"GO:0031175") association act(p(GFAM:"Mitogen-activated protein kinases")) |
| pmid:18986241 | path(MESH:D003072) negativeCorrelation p(HGNC:NTRK1) |
| pmid:18986241 | path(MESH:D003072) positiveCorrelation a(MESHC:"pro-nerve growth factor, human") |
| pmid:18986241 | path(MESH:D003072) positiveCorrelation act(p(HGNC:MMP9)) |
| pmid:18986241 | complex(a(MESHC:"pro-nerve growth factor, human"), p(HGNC:NGFR)) increases bp(GO:"GO:0006915") |
| pmid:18986241 | bp(GO:"GO:0006915") association bp(GO:"GO:0000165") |
| pmid:18986241 | bp(MESH:D000375) increases p(HGNC:NGFR) |
| pmid:18986241 | composite(a(MESHC:"pro-nerve growth factor, human"), complex(p(HGNC:NGFR), p(HGNC:SORT1))) increases bp(GO:"GO:0006915") |
| pmid:18986241 | p(HGNC:SORT1) association path(MESH:D000544) |
| pmid:18986241 | act(p(HGNC:MMP9)) positiveCorrelation path(MESH:D003072) |
| pmid:27594586 | p(HGNC:MMP9) increases p(HGNC:HTT, frag("?")) |
| pmid:27594586 | act(p(HGNC:MMP9)) association path(MESH:"Neurodevelopmental Disorders") |
| pmid:27594586 | act(p(HGNC:MMP9)) increases bp(GO:"neuron death") |
| pmid:27594586 | p(HGNC:MMP9) increases bp(GO:"neuron death") |
| pmid:27594586 | act(p(HGNC:MMP9)) positiveCorrelation p(FPLX:ERK, pmod(Ph)) |
| pmid:27594586 | sec(p(HGNC:MMP9)) positiveCorrelation p(FPLX:ERK, pmod(Ph)) |
| pmid:29626319 | act(p(HGNC:MMP9)) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:MMP9) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:18986241 | g(HGNC:NTRK1) association path(MESH:D003071) |
| pmid:18986241 | g(HGNC:NTRK2) association path(MESH:D003071) |
| pmid:18986241 | g(HGNC:NTRK3) association path(MESH:D003071) |
| pmid:18986241 | bp(GO:"GO:0000165") association bp(GO:"GO:0006915") |
| pmid:18986241 | bp(GO:"GO:0000165") association bp(GO:"GO:0030182") |
| pmid:18986241 | bp(GO:"GO:0000165") increases act(p(FPLX:RAS)) |
| pmid:18986241 | bp(GO:"GO:0000165") increases act(p(FPLX:RAF)) |
| pmid:18986241 | bp(GO:"GO:0000165") increases act(p(FPLX:MEK)) |
| pmid:18986241 | bp(GO:"GO:0000165") increases act(p(FPLX:P90RSK)) |
| pmid:18986241 | bp(GO:"GO:0000165") increases act(p(HGNC:MAPKAPK2)) |
| pmid:18986241 | bp(GO:"GO:0030182") association bp(GO:"GO:0000165") |
| pmid:18986241 | p(GFAM:"Mitogen-activated protein kinases", pmod(Ph)) increases act(p(GFAM:"Mitogen-activated protein kinases")) |
| pmid:18986241 | act(p(GFAM:"Mitogen-activated protein kinases")) association bp(GO:"GO:0031175") |
| pmid:18986241 | act(p(HGNC:MAPKAPK2)) increases p(HGNC:ELK1, pmod(Ph)) |
| pmid:18986241 | act(p(HGNC:MAPKAPK2)) increases p(HGNC:CREB1, pmod(Ph)) |
| pmid:18986241 | bp(GO:"GO:0014065") regulates bp(MESH:D002470) |
| pmid:18986241 | bp(GO:"GO:0014065") association p(FPLX:RAS) |
| pmid:18986241 | bp(GO:"GO:0014065") association p(HGNC:IRS1) |
| pmid:18986241 | bp(GO:"GO:0014065") association p(HGNC:GAB1) |
| pmid:18986241 | bp(GO:"GO:0043491") regulates bp(MESH:D002470) |
| pmid:18986241 | bp(GO:"GO:0043491") association p(FPLX:RAS) |
| pmid:18986241 | bp(GO:"GO:0043491") association p(HGNC:IRS1) |
| pmid:18986241 | bp(GO:"GO:0043491") association p(HGNC:GAB1) |
| pmid:18986241 | p(HGNC:IRS1) association bp(GO:"GO:0014065") |
| pmid:18986241 | p(HGNC:IRS1) association bp(GO:"GO:0043491") |
| pmid:18986241 | p(HGNC:GAB1) association bp(GO:"GO:0014065") |
| pmid:18986241 | p(HGNC:GAB1) association bp(GO:"GO:0043491") |
| pmid:18986241 | act(p(HGNC:PLCG1)) association bp(MESH:D018384) |
| pmid:18467332 | p(HGNC:PLCG1) isA complex(p(HGNC:MAPT), p(HGNC:PLCG1)) |
| pmid:18986241 | bp(MESH:D018384) association act(p(HGNC:PLCG1)) |
| pmid:18986241 | bp(MESH:D018384) association path(MESH:D000375) |
| pmid:18986241 | bp(MESH:D018384) association path(MESH:D009410) |
| pmid:18986241 | path(MESH:D000375) association bp(MESH:D018384) |
| pmid:18986241 | path(MESH:D009410) association bp(MESH:D018384) |
| pmid:18986241 | bp(GO:"GO:0006665") association act(p(HGNC:NGFR)) |
| pmid:18986241 | complex(a(MESHC:"gambogic amide"), p(HGNC:NTRK1)) directlyIncreases p(HGNC:NTRK1, pmod(Ph)) |
| pmid:18986241 | a(MESHC:"gambogic amide") decreases bp(HBP:Excitotoxicity) |
| pmid:18986241 | a(MESHC:"gambogic amide") increases bp(GO:"GO:0031175") |
| pmid:18986241 | p(HGNC:NTRK1, pmod(Ph)) increases bp(GO:"GO:0043491") |
| pmid:18986241 | p(HGNC:NTRK1, pmod(Ph)) increases bp(GO:"GO:0000165") |
| pmid:18986241 | path(MESH:D024801) association p(HGNC:CHRM1) |
| pmid:18986241 | path(MESH:D000686) association p(HGNC:CHRM1) |
| pmid:18986241 | a(MESHC:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases path(MESH:D060825) |
| pmid:18986241 | a(MESHC:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases path(MESH:D024801) |
| pmid:18986241 | a(MESHC:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:18986241 | a(MESHC:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") increases act(p(MGI:Chrm1)) |
| pmid:18986241 | a(MESHC:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(MGI:Bace1) |
| pmid:18986241 | a(MESHC:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases act(p(MGI:Gsk3b)) |
| pmid:26751493 | r(HGNC:SYP) negativeCorrelation a(GO:"neurofibrillary tangle") |
| pmid:18986241 | p(GFAM:Synaptotagmins) association bp(GO:"GO:0031629") |
| pmid:18986241 | p(GFAM:Synaptotagmins) association bp(GO:"GO:0007269") |
| pmid:18986241 | bp(GO:"GO:0031629") association p(GFAM:Synaptotagmins) |
| pmid:18986241 | bp(GO:"GO:0007269") association p(GFAM:Synaptotagmins) |
| pmid:18986241 | bp(GO:"GO:0007269") association p(HGNC:NGF) |
| pmid:18986241 | p(GFAM:"Protein phosphatase catalytic subunits") increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:18986241 | act(p(GFAM:"Protein phosphatase catalytic subunits")) decreases bp(HBP:hyperphosphorylation) |
| pmid:18986241 | bp(HBP:hyperphosphorylation) association path(MESH:D016874) |
| pmid:17493042 | p(HBP:"Tau isoform B (381 aa)") partOf a(MESH:Brain) |
| pmid:23407988 | p(HBP:"Tau isoform B (381 aa)") isA p(HBP:"3R tau") |
| pmid:17493042 | p(HBP:"Tau isoform C (410 aa)") partOf a(MESH:Brain) |
| pmid:23407988 | p(HBP:"Tau isoform C (410 aa)") isA p(HBP:"3R tau") |
| pmid:17493042 | p(HBP:"Tau isoform D (383 aa)") partOf a(MESH:Brain) |
| pmid:23407988 | p(HBP:"Tau isoform D (383 aa)") isA p(HBP:"4R tau") |
| pmid:17493042 | p(HBP:"Tau isoform E (412 aa)") partOf a(MESH:Brain) |
| pmid:23407988 | p(HBP:"Tau isoform E (412 aa)") isA p(HBP:"4R tau") |
| pmid:17493042 | p(HBP:"Tau isoform F (441 aa)") partOf a(MESH:Brain) |
| pmid:23407988 | p(HBP:"Tau isoform F (441 aa)") isA p(HBP:"4R tau") |
| pmid:27574109 | a(HBP:"3R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pmid:27574109 | a(HBP:"3R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pmid:27574109 | a(HBP:"3R tau") positiveCorrelation bp(GO:"positive regulation of protein oligomerization") |
| pmid:27574109 | a(HBP:"3R tau") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27574109 | a(HBP:"3R tau") positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pmid:18986241 | act(p(HGNC:GAL)) association path(MESH:D003071) |
| pmid:18986241 | act(p(HGNC:GAL)) association bp(MESH:D009473) |
| pmid:18986241 | act(p(HGNC:GAL)) increases bp(GO:"GO:0060384") |
| pmid:18986241 | act(p(HGNC:GAL)) regulates act(a(MESH:D059329)) |
| pmid:18986241 | act(p(HGNC:GAL)) decreases a(CHEBI:"amyloid-beta") |
| pmid:18986241 | act(p(HGNC:GAL)) increases r(HGNC:CHAT) |
| pmid:18986241 | act(p(HGNC:GAL)) causesNoChange a(HBP:"Tau MN423") |
| pmid:18986241 | act(p(HGNC:GAL)) increases r(HGNC:PPP1CA) |
| pmid:18986241 | act(p(HGNC:GAL)) increases r(HGNC:PPP1CC) |
| pmid:18986241 | bp(MESH:D009473) association act(p(HGNC:GAL)) |
| pmid:18986241 | a(HBP:"Tau C3") biomarkerFor path(MESH:D059329) |
| pmid:18986241 | p(RGD:Ngf) increases r(RGD:Gal) |
| pmid:18986241 | p(RGD:Ngf) decreases path(MESH:D060825) |
| pmid:18986241 | bp(GO:"GO:0050435") association a(MESH:D002800) |
| pmid:18986241 | path(MESH:D007319) association a(MESH:D002800) |
| pmid:18986241 | path(MESH:D003967) association a(MESH:D002800) |
| pmid:18986241 | path(MESH:D009325) association a(MESH:D002800) |
| pmid:18986241 | path(MESH:D005221) association a(MESH:D002800) |
| pmid:18986241 | path(MESH:D000855) association a(MESH:D002800) |
| pmid:18986241 | bp(GO:"GO:0048485") association p(HGNC:NGF) |
| pmid:18986241 | path(MESH:D002100) association p(HGNC:NGF) |
| pmid:18986241 | path(MESH:D006930) association p(HGNC:NGF) |
| pmid:18986241 | g(HGNC:NGF) directlyIncreases p(HGNC:NGF) |
| pmid:18986241 | a(MESHC:latrepirdine) decreases act(p(HGNC:BCHE)) |
| pmid:18986241 | a(MESHC:latrepirdine) decreases act(p(HGNC:ACHE)) |
| pmid:18986241 | a(MESHC:latrepirdine) decreases bp(GO:"GO:0098989") |
| pmid:18986241 | a(MESHC:latrepirdine) decreases bp(GO:"GO:0046902") |
| pmid:18986241 | a(MESHC:latrepirdine) increases bp(MESH:D000066829) |
| pmid:11230871 | a(MESH:"Neurotransmitter Agents") association p(FPLX:CHRN) |
| pmid:11230871 | path(MESH:"Tourette Syndrome") association p(FPLX:CHRN) |
| pmid:11230871 | a(PUBCHEM:5662) association bp(GO:"synaptic transmission, cholinergic") |
| pmid:11230871 | a(PUBCHEM:132228) increases p(FPLX:CHRN) |
| pmid:11230871 | a(CHEBI:Ondansetron) decreases p(FPLX:CHRN) |
| pmid:11230871 | a(PUBCHEM:119380) increases path(MESH:"Verbal Learning") |
| pmid:11230871 | a(PUBCHEM:119380) increases bp(GO:memory) |
| pmid:28132910 | a(HBP:"B-973") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28132910 | a(HBP:"B-973") negativeCorrelation act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28132910 | a(HBP:"B-973") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28132910 | a(HBP:"B-973") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:28132910 | a(HBP:"B-973") increases act(a(CHEBI:acetylcholine)) |
| pmid:28132910 | a(HBP:"B-973") increases complex(a(GO:membrane), a(PUBCHEM:16068384)) |
| pmid:28132910 | a(HBP:"B-973") increases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384)) |
| pmid:28132910 | a(HBP:"B-973") increases complex(a(PUBCHEM:16068384), p(MGI:Chrna7)) |
| pmid:28132910 | a(PUBCHEM:5288811) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) |
| pmid:17640819 | composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu")), p(MGI:Psen1, var("p.Met146Leu"))) increases a(CHEBI:"amyloid-beta") |
| pmid:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") decreases act(p(MGI:App, frag("25_35"))) |
| pmid:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") decreases act(p(MGI:App, frag("25_35"))) |
| pmid:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases bp(GO:learning) |
| pmid:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases bp(GO:learning) |
| pmid:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases path(MESH:"Spatial Memory") |
| pmid:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases path(MESH:"Spatial Memory") |
| pmid:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") causesNoChange r(MGI:Chrna7) |
| pmid:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases p(MGI:Chrna7) |
| pmid:25881725 | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases p(MGI:Chrna7) |
| pmid:19721446 | a(MESH:"Peripheral Nervous System") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19721446 | a(MESH:"Central Nervous System") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| pmid:19721446 | bp(GO:"regulation of cation channel activity") association a(CHEBI:acetylcholine) |
| pmid:19721446 | p(HGNC:CHRNA7, frag("231_255")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) |
| pmid:19721446 | p(HGNC:CHRNA7, frag("231_255")) association act(a(PUBCHEM:11964458)) |
| pmid:19721446 | act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("231_255")) |
| pmid:19721446 | act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("262_280")) |
| pmid:19721446 | act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("470_490")) |
| pmid:19721446 | p(HGNC:CHRNA7, frag("262_280")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) |
| pmid:19721446 | p(HGNC:CHRNA7, frag("262_280")) association act(a(PUBCHEM:11964458)) |
| pmid:19721446 | p(HGNC:CHRNA7, frag("470_490")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) |
| pmid:19721446 | p(HGNC:CHRNA7, frag("470_490")) association act(a(PUBCHEM:11964458)) |
| pmid:19721446 | act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("231_255")) |
| pmid:19721446 | act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("262_280")) |
| pmid:19721446 | act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("470_490")) |
| pmid:19721446 | p(HGNC:CHRNA4, frag("331_600")) association p(HGNC:YWHAH) |
| pmid:19721446 | p(HGNC:CHRNA4, frag("331_600")) association p(HGNC:VSNL1) |
| pmid:19721446 | p(HGNC:YWHAH) association p(HGNC:CHRNA4, frag("331_600")) |
| pmid:19721446 | p(HGNCGENEFAMILY:Tubulins) association p(HGNC:CHRNB2) |
| pmid:19721446 | p(HGNCGENEFAMILY:"Clathrin subunits") association p(HGNC:CHRNB2) |
| pmid:19721446 | a(MESH:"AR-R 17779") increases bp(GO:learning) |
| pmid:19721446 | a(MESH:"AR-R 17779") increases bp(GO:memory) |
| pmid:19721446 | a(MESH:"AR-R 17779") decreases act(a(CHEBI:scopolamine)) |
| pmid:19721446 | a(DRUGBANK:Facinicline) increases bp(GO:cognition) |
| pmid:19721446 | a(DRUGBANK:Facinicline) increases bp(GO:memory) |
| pmid:19721446 | a(DRUGBANK:Facinicline) increases path(MESH:"Memory, Episodic") |
| pmid:19721446 | a(MESH:"alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid") increases path(HBP:neurotoxicity) |
| pmid:19721446 | a(MESH:"Entorhinal Cortex") association bp(GO:memory) |
| pmid:19721446 | path(MESH:"Attention Deficit Disorder with Hyperactivity") association a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole") |
| pmid:19721446 | path(MESH:"Attention Deficit Disorder with Hyperactivity") association a(MESH:pozanicline) |
| pmid:19721446 | a(MESH:pozanicline) association path(MESH:"Attention Deficit Disorder with Hyperactivity") |
| pmid:19721446 | bp(MESH:"Sensory Gating") association path(MESH:Schizophrenia) |
| pmid:19721446 | bp(MESH:"Sensory Gating") association p(HGNC:CHRNA7) |
| pmid:19721446 | a(CHEBI:clozapine) increases bp(MESH:"Sensory Gating") |
| pmid:19721446 | a(CHEBI:clozapine) association p(HGNC:CHRNA7) |
| pmid:19721446 | a(CHEBI:tropisetron) increases act(p(HGNC:CHRNA7)) |
| pmid:19721446 | a(CHEBI:tropisetron) decreases bp(MESH:"Sensory Gating") |
| pmid:19721446 | a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(CHEBI:nicotine)) |
| pmid:19721446 | a(MESH:"Dihydro-beta-Erythroidine") decreases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:28901280 | a(MESH:"Dihydro-beta-Erythroidine") decreases p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:Nicotine)) |
| pmid:19721446 | a(CHEBI:varenicline) increases path(MESH:"Smoking Cessation") |
| pmid:19721446 | a(CHEBI:varenicline) increases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19721446 | a(CHEBI:varenicline) increases act(p(HGNC:CHRNA7)) |
| pmid:19721446 | complex(p(HGNC:CHRNA4), p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) association a(MESH:"Dopaminergic Neurons") |
| pmid:19721446 | complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) association a(MESH:"Dopaminergic Neurons") |
| pmid:19721446 | complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2)) association a(MESH:"Dopaminergic Neurons") |
| pmid:19721446 | g(HGNC:CHRNA5) association path(MESH:"Lung Neoplasms") |
| pmid:19721446 | g(HGNC:CHRNA3) association path(MESH:"Lung Neoplasms") |
| pmid:19721446 | g(HGNC:CHRNB4) association path(MESH:"Lung Neoplasms") |
| pmid:19721446 | path(MESH:Recurrence) association p(HGNC:CHRNA3) |
| pmid:19721446 | path(MESH:Recurrence) association p(HGNC:CHRNB4) |
| pmid:19721446 | a(CHEBI:fluoxetine) decreases a(CHEBI:monoamine) |
| pmid:19721446 | a(CHEBI:fluoxetine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19721446 | a(CHEBI:sertraline) decreases a(CHEBI:monoamine) |
| pmid:19721446 | a(CHEBI:sertraline) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19721446 | a(CHEBI:paroxetine) decreases a(CHEBI:monoamine) |
| pmid:19721446 | a(CHEBI:paroxetine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19721446 | a(CHEBI:nefazodone) decreases a(CHEBI:monoamine) |
| pmid:19721446 | a(CHEBI:nefazodone) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19721446 | a(CHEBI:nisoxetine) decreases a(CHEBI:monoamine) |
| pmid:19721446 | a(CHEBI:nisoxetine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19721446 | a(CHEBI:nomifensine) decreases a(CHEBI:monoamine) |
| pmid:19721446 | a(CHEBI:nomifensine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19721446 | a(CHEBI:vanoxerine) decreases a(CHEBI:monoamine) |
| pmid:19721446 | a(CHEBI:vanoxerine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) |
| pmid:19721446 | a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") increases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19721446 | a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") association path(MESH:Vomiting) |
| pmid:19721446 | a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") association path(MESH:Nausea) |
| pmid:19721446 | a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") increases act(complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4))) |
| pmid:19721446 | a(MESH:"3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo(3.2.0)heptane") increases act(p(HBP:"alpha-4 beta-2 nAChR")) |
| pmid:19721446 | complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) association a(MESH:Conotoxins) |
| pmid:19721446 | complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) increases act(a(MESH:Lymphocytes)) |
| pmid:28901280 | complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) increases p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | path(MESH:Pain) association p(MESH:"Receptors, Nicotinic") |
| pmid:22040696 | p(FPLX:Cyclophilin) increases p(HGNC:CHRNA7) |
| pmid:22040696 | p(FPLX:"p14_3_3") increases p(FPLX:CHRN) |
| pmid:22040696 | p(HGNC:HSPA5) increases p(FPLX:CHRN) |
| pmid:22040696 | p(HGNC:CANX) increases p(FPLX:CHRN) |
| pmid:22040696 | complex(GO:"proteasome complex") regulates p(FPLX:CHRN) |
| pmid:22040696 | complex(GO:"proteasome complex") increases bp(GO:"modulation of chemical synaptic transmission") |
| pmid:22040696 | complex(GO:"proteasome complex") regulates p(HGNC:RIC3) |
| pmid:14556719 | complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(GO:"protein K48-linked ubiquitination"))) |
| pmid:14556719 | complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(GO:"protein K63-linked ubiquitination"))) |
| pmid:14556719 | complex(GO:"proteasome complex") increases deg(complex(p(HGNC:OAZ1), p(HGNC:ODC1))) |
| pmid:14556719 | complex(GO:"proteasome complex") increases a(CHEBI:peptide) |
| pmid:14556719 | complex(GO:"proteasome complex") regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:14556719 | complex(GO:"proteasome complex") increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:14556719 | act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:aging) |
| pmid:14556719 | act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:SOD1, var("?")) |
| pmid:14556719 | act(complex(GO:"proteasome complex")) decreases bp(GO:autophagy) |
| pmid:14556719 | act(complex(GO:"proteasome complex")) decreases p(HGNC:HTT, frag("?")) |
| pmid:24457024 | complex(GO:"proteasome complex") regulates complex(a(MESH:Proteins), a(MESH:Ubiquitin)) |
| pmid:30116051 | complex(GO:"proteasome complex") increases deg(p(HGNC:MAPT)) |
| pmid:26751493 | act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:MAPT) |
| pmid:17954934 | act(complex(GO:"proteasome complex")) increases deg(p(HGNC:MAPT)) |
| pmid:17954934 | act(complex(GO:"proteasome complex")) isA complex(GO:"proteasome complex") |
| pmid:17954934 | act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:BAG1) |
| pmid:19732809 | act(complex(GO:"proteasome complex")) negativeCorrelation a(HBP:"O-GlcNAcylation") |
| pmid:19732809 | act(complex(GO:"proteasome complex")) positiveCorrelation g(HGNC:OGT) |
| pmid:26041011 | act(complex(GO:"proteasome complex")) decreases a(HBP:"Tau aggregates") |
| pmid:26692334 | act(complex(GO:"proteasome complex")) positiveCorrelation act(p(FPLX:PKA)) |
| pmid:22040696 | composite(p(HGNC:HTR3A), p(HGNC:RIC3)) decreases surf(p(HGNC:HTR3A)) |
| pmid:22040696 | p(UNIPROT:P34371) increases act(p(FPLX:CHRN)) |
| pmid:22040696 | p(FPLX:CHRN, pmod(Ph, Tyr)) decreases act(p(FPLX:CHRN)) |
| pmid:22040696 | complex(p(FPLX:CHRN), p(FPLX:SRC)) increases bp(GO:"catecholamine secretion") |
| pmid:22040696 | complex(p(FPLX:CHRN), p(HGNC:FYN)) increases bp(GO:"catecholamine secretion") |
| pmid:22040696 | complex(p(HGNC:CHRNA7), p(HGNC:FYN)) increases act(p(FPLX:PI3K)) |
| pmid:22040696 | complex(p(HGNC:CHRNA7), p(HGNC:JAK2)) increases act(p(FPLX:PI3K)) |
| pmid:22040696 | p(HGNC:CHRNA7, pmod(Ph, Tyr)) decreases act(p(HGNC:CHRNA7)) |
| pmid:22040696 | p(HGNC:BDNF) regulates bp(GO:"peripheral nervous system development") |
| pmid:22040696 | p(HGNC:BDNF) regulates bp(GO:"central nervous system development") |
| pmid:22040696 | p(HGNC:BDNF) increases bp(GO:"regulation of synaptic plasticity") |
| pmid:22040696 | p(HGNC:BDNF) increases bp(GO:"spontaneous synaptic transmission") |
| pmid:22040696 | p(HGNC:BDNF) increases bp(GO:"synaptic transmission, GABAergic") |
| pmid:22040696 | p(HGNC:BDNF) increases bp(GO:"maintenance of synapse structure") |
| pmid:22040696 | p(HGNC:BDNF) association p(HGNC:CHRNA7) |
| pmid:22040696 | p(HGNC:BDNF) increases p(HGNC:CHRNA7) |
| pmid:22040696 | p(HGNC:BDNF) increases surf(p(HGNC:CHRNA7)) |
| pmid:28632203 | p(HGNC:BDNF) biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:21787755 | bp(GO:"maintenance of synapse structure") association a(HBP:"alpha-7-containing nAChR") |
| pmid:22040696 | act(a(MESH:"SNARE Proteins")) increases tloc(p(HGNC:CHRNA7), fromLoc(GO:"cell surface"), toLoc(GO:endosome)) |
| pmid:22040696 | act(a(MESH:"SNARE Proteins")) causesNoChange surf(p(HGNC:CHRNA7)) |
| pmid:22040696 | p(HGNC:CHRNA7, var("p.Leu335Ala")) decreases surf(p(HGNC:CHRNA7)) |
| pmid:22040696 | p(HGNC:CHRNA7, var("p.Leu336Ala")) decreases surf(p(HGNC:CHRNA7)) |
| pmid:22040696 | p(HGNC:CHRNA7, var("p.Leu343Ala")) decreases surf(p(HGNC:CHRNA7)) |
| pmid:22040696 | r(HGNC:RIC3) positiveCorrelation path(MESH:Schizophrenia) |
| pmid:22040696 | r(HGNC:RIC3) positiveCorrelation path(MESH:"Bipolar Disorder") |
| pmid:22040696 | path(MESH:"Bipolar Disorder") positiveCorrelation r(HGNC:RIC3) |
| pmid:22040696 | path(MESH:"Bipolar Disorder") negativeCorrelation act(p(HGNC:RIC3), ma(chap)) |
| pmid:22040696 | bp(GO:"response to ischemia") increases path(MESH:"Renal Insufficiency") |
| pmid:18174175 | complex(a(CHEBI:epibatidine), a(HBP:"alpha-3 beta-2 nAChR")) increases act(a(HBP:"alpha-3 beta-2 nAChR")) |
| pmid:21787755 | bp(GO:"neuron projection maintenance") association a(HBP:"alpha-7-containing nAChR") |
| pmid:21787755 | a(HBP:AβOs) association path(MESH:"Tobacco Use Disorder") |
| pmid:21787755 | a(HBP:AβOs) association path(MESH:"Alzheimer Disease") |
| pmid:21787755 | a(HBP:AβOs) association path(MESH:Epilepsy) |
| pmid:21787755 | a(HBP:"alpha-4 beta-4 nAChR") association path(MESH:"Tobacco Use Disorder") |
| pmid:21787755 | path(MESH:Seizures) association a(HBP:"alpha-7-containing nAChR") |
| pmid:21787755 | a(HBP:"alpha-6-containing nAChR") association path(MESH:Pleasure) |
| pmid:21787755 | a(HBP:"alpha-6-containing nAChR") association path(MESH:Reward) |
| pmid:21787755 | a(HBP:"alpha-6-containing nAChR") association path(MESH:Affect) |
| pmid:21787755 | a(HBP:"alpha-6-containing nAChR") regulates sec(a(CHEBI:"gamma-aminobutyric acid")) |
| pmid:21787755 | a(HBP:"alpha-6-containing nAChR") association path(MESH:"Tobacco Use Disorder") |
| pmid:21787755 | a(HBP:"alpha-6-containing nAChR") regulates bp(GO:"neurotransmitter secretion") |
| pmid:21787755 | path(MESH:Pleasure) association a(HBP:"alpha-6-containing nAChR") |
| pmid:21787755 | path(MESH:Reward) association a(HBP:"alpha-6-containing nAChR") |
| pmid:21787755 | path(MESH:Reward) association r(HGNC:CHRNA6) |
| pmid:21787755 | path(MESH:Reward) association p(HGNC:CHRNA6) |
| pmid:28901280 | path(MESH:Reward) association p(MESH:"Receptors, Nicotinic") |
| pmid:21787755 | path(MESH:Affect) association a(HBP:"alpha-6-containing nAChR") |
| pmid:21787755 | a(MESH:"neuronal bungarotoxin") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) |
| pmid:21787755 | a(MESH:"neuronal bungarotoxin") decreases act(a(HBP:"alpha-6-containing nAChR")) |
| pmid:21787755 | a(MESH:"alpha-conotoxin PnIA") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) |
| pmid:21787755 | a(MESH:"alpha-conotoxin PnIA") decreases act(a(HBP:"alpha-6-containing nAChR")) |
| pmid:21787755 | bp(MESH:"Drug Interactions") association r(HGNC:CHRNA6) |
| pmid:21787755 | bp(MESH:"Drug Interactions") association p(HGNC:CHRNA6) |
| pmid:28901280 | complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases act(a(MESH:"Peripheral Nervous System")) |
| pmid:28901280 | complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(MESH:Sodium), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28901280 | complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"calcium cation"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28901280 | complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) |
| pmid:28901280 | a(MESH:Acetylcholine) association bp(GO:"cell-cell signaling") |
| pmid:28901280 | a(MESH:Acetylcholine) association bp(HBP:"cell population proliferation") |
| pmid:28901280 | a(MESH:Acetylcholine) association bp(GO:"cell adhesion") |
| pmid:28901280 | a(MESH:Acetylcholine) association bp(MESH:"Cell Movement") |
| pmid:28901280 | a(MESH:Acetylcholine) association bp(GO:"secretion by cell") |
| pmid:28901280 | a(MESH:Acetylcholine) association bp(MESH:"Cell Survival") |
| pmid:28901280 | a(MESH:Acetylcholine) association bp(MESH:Apoptosis) |
| pmid:28901280 | a(MESH:Acetylcholine) association bp(MESH:"Autocrine Communication") |
| pmid:28901280 | a(MESH:Acetylcholine) association bp(MESH:"Paracrine Communication") |
| pmid:28901280 | a(MESH:Acetylcholine) association bp(HBP:"juxtacrine signaling") |
| pmid:28901280 | a(MESH:Acetylcholine) decreases path(MESH:Inflammation) |
| pmid:28901280 | a(MESH:Acetylcholine) increases path(MESH:Neoplasms) |
| pmid:28901280 | a(MESH:Acetylcholine) increases act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) |
| pmid:28901280 | a(MESH:Acetylcholine) increases act(p(HGNC:CHRNA9)) |
| pmid:28901280 | complex(a(MESH:Nicotine), p(MESH:"Receptors, Nicotinic"), loc(MESH:Brain)) decreases path(MESH:Anxiety) |
| pmid:28901280 | a(MESH:Nicotine) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) |
| pmid:28901280 | a(MESH:Nicotine) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| pmid:28901280 | a(MESH:Nicotine) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) |
| pmid:28901280 | a(MESH:Nicotine) decreases a(MESH:Neurons) |
| pmid:28901280 | a(MESH:Nicotine) decreases p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | a(MESH:Nicotine) increases bp(GO:"nodal receptor complex assembly") |
| pmid:28901280 | a(MESH:Nicotine) increases act(p(MESH:"Proteasome Endopeptidase Complex")) |
| pmid:28901280 | a(MESH:Nicotine) increases a(MESH:Glutamates) |
| pmid:28901280 | a(MESH:Nicotine) increases a(MESH:Glutamates) |
| pmid:28901280 | a(MESH:Nicotine) increases p(MESH:"Receptors, GABA") |
| pmid:28901280 | a(MESH:Nicotine) decreases p(MESH:"Receptors, GABA") |
| pmid:28901280 | a(MESH:Nicotine) increases bp(GO:"action potential initiation") |
| pmid:28901280 | a(MESH:Nicotine) increases a(MESH:Dopamine) |
| pmid:28901280 | a(MESH:Nicotine) increases a(MESH:Dopamine) |
| pmid:28901280 | a(MESH:Nicotine) increases act(p(HGNC:CHRNA7)) |
| pmid:28901280 | a(MESH:Nicotine) decreases act(p(HGNC:CHRNA7)) |
| pmid:28901280 | a(MESH:Nicotine) increases p(MESH:"Receptors, N-Methyl-D-Aspartate") |
| pmid:28901280 | a(MESH:Nicotine) increases bp(MESH:"Long-Term Potentiation") |
| pmid:28901280 | act(a(MESH:Nicotine)) association g(DNSNP:rs16969968) |
| pmid:28901280 | a(MESH:Nicotine) increases path(MESH:Neoplasms) |
| pmid:28901280 | a(MESH:Nicotine) causesNoChange act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) |
| pmid:28901280 | a(MESH:Nicotine) causesNoChange act(p(HGNC:CHRNA9)) |
| pmid:28901280 | complex(a(MESH:"Receptors, Muscarinic"), a(MESH:Acetylcholine)) increases act(a(MESH:"Central Nervous System")) |
| pmid:28901280 | bp(GO:"cell-cell signaling") association a(MESH:Acetylcholine) |
| pmid:28901280 | bp(HBP:"cell population proliferation") association a(MESH:Acetylcholine) |
| pmid:28901280 | bp(HBP:"cell population proliferation") association p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | bp(MESH:"Cell Movement") association a(MESH:Acetylcholine) |
| pmid:28901280 | bp(GO:"secretion by cell") association a(MESH:Acetylcholine) |
| pmid:28901280 | bp(MESH:Apoptosis) association a(MESH:Acetylcholine) |
| pmid:28901280 | bp(MESH:"Autocrine Communication") association a(MESH:Acetylcholine) |
| pmid:28901280 | bp(MESH:"Paracrine Communication") association a(MESH:Acetylcholine) |
| pmid:28901280 | bp(HBP:"juxtacrine signaling") association a(MESH:Acetylcholine) |
| pmid:28901280 | a(MESH:Erythrocytes) increases a(MESH:Acetylcholine) |
| pmid:28901280 | a(MESH:Erythrocytes) increases a(MESH:"Choline O-Acetyltransferase") |
| pmid:29626319 | a(MESH:Erythrocytes) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(MESH:Erythrocytes) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:28901280 | a(MESH:"Epithelial Cells") increases a(MESH:Acetylcholine) |
| pmid:28901280 | a(MESH:"Epithelial Cells") increases a(MESH:"Choline O-Acetyltransferase") |
| pmid:28901280 | path(MESH:Learning) association p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | bp(MESH:Analgesia) association p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | p(HGNC:CHRFAM7A, loc(MESH:Oocytes)) decreases act(p(HGNC:CHRNA7, loc(MESH:Oocytes))) |
| pmid:28901280 | bp(GO:"cell differentiation") association p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | a(HBP:cytisine) decreases p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | a(HBP:cytisine) decreases act(a(MESH:Nicotine)) |
| pmid:28901280 | a(MESH:Carbachol) decreases p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | a(MESH:Carbachol) decreases act(a(MESH:Nicotine)) |
| pmid:28901280 | a(MESH:Varenicline) decreases p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | a(MESH:Varenicline) decreases act(a(MESH:Nicotine)) |
| pmid:28901280 | a(MESH:Mecamylamine) decreases p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | a(MESH:Mecamylamine) decreases act(a(MESH:Nicotine)) |
| pmid:28901280 | a(HBP:neurotransmitters) association p(MESH:"Receptors, Nicotinic", loc(MESH:"GABAergic Neurons")) |
| pmid:28901280 | a(HBP:neurotransmitters) association p(MESH:"Receptors, Nicotinic", loc(MESH:"Cholinergic Neurons")) |
| pmid:28901280 | a(MESH:Glutamates) increases bp(MESH:"Long-Term Potentiation") |
| pmid:28901280 | a(MESH:Glutamates) increases bp(GO:"action potential initiation") |
| pmid:27796283 | bp(MESH:"Long-Term Potentiation") association p(HGNC:CAMKV) |
| pmid:27041503 | bp(MESH:"Long-Term Potentiation") negativeCorrelation bp(GO:"actin filament polymerization") |
| pmid:27041503 | bp(MESH:"Long-Term Potentiation") negativeCorrelation p(HGNC:WWC1) |
| pmid:27041503 | bp(MESH:"Long-Term Potentiation") positiveCorrelation bp(GO:memory) |
| pmid:28901280 | bp(HBP:"habenulo-interpeduncular pathway") increases p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | bp(HBP:"habenulo-interpeduncular pathway") increases p(HGNC:CHRNA3, loc(MESH:"Central Nervous System")) |
| pmid:28901280 | bp(HBP:"habenulo-interpeduncular pathway") increases p(HGNC:CHRNB4, loc(MESH:"Central Nervous System")) |
| pmid:28901280 | bp(HBP:"habenulo-interpeduncular pathway") increases p(HGNC:CHRNA5, loc(MESH:"Central Nervous System")) |
| pmid:28901280 | g(DNSNP:rs16969968) association act(a(MESH:Nicotine)) |
| pmid:28901280 | p(MGI:Chrna5) regulates act(a(MESH:Nicotine)) |
| pmid:28901280 | p(MGI:Chrna5) increases a(MESH:Nicotine) |
| pmid:28901280 | p(MGI:Chrnb4) decreases act(a(MESH:Nicotine)) |
| pmid:28901280 | p(MGI:Chrna2) increases a(MESH:Nicotine) |
| pmid:28901280 | a(CHEBI:"calcium cation") increases bp(MESH:"Cell Proliferation") |
| pmid:28901280 | a(CHEBI:"calcium cation") increases bp(MESH:"Cell Movement") |
| pmid:28901280 | a(CHEBI:"calcium cation") decreases bp(MESH:Apoptosis) |
| pmid:28901280 | p(HBP:"LY6 family") regulates p(MESH:"Receptors, Nicotinic") |
| pmid:28901280 | g(DNSNP:rs1051730) association path(MESH:"Lung Neoplasms") |
| pmid:28901280 | g(DNSNP:rs1051730) association path(MESH:"Tobacco Use Disorder") |
| pmid:28901280 | bp(GO:"JAK-STAT cascade") increases a(CHEBI:"calcium cation", loc(GO:intracellular)) |
| pmid:28901280 | a(MESH:Epithelium) regulates a(MESH:Acetylcholine) |
| pmid:28901280 | act(a(MESH:Epithelium)) association p(MGI:Chrna7) |
| pmid:28901280 | a(MESH:Choline) increases act(p(HGNC:CHRNA9)) |
| pmid:28901280 | a(MESH:Phosphorylcholine) causesNoChange complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) |
| pmid:28901280 | a(MESH:Phosphorylcholine) causesNoChange p(HGNC:CHRNA9) |
| pmid:28901280 | a(MESH:"Ganglia, Spinal") increases complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) |
| pmid:28901280 | a(MESH:"Ganglia, Spinal") increases p(HGNC:CHRNA9) |
| pmid:28901280 | path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA9) |
| pmid:28901280 | path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA5) |
| pmid:28901280 | path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA10) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) regulates bp(GO:"inflammatory response") |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(MGI:Tnf) |
| pmid:23383175 | a(CHEBI:Anatabine) causesNoChange p(MGI:Tnf) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Tnf) |
| pmid:23178521 | a(CHEBI:Anatabine) decreases p(MGI:Il6) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Il6) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases a(MESH:Cytokines) |
| pmid:23383175 | a(CHEBI:Anatabine) negativeCorrelation path(MESH:Encephalomyelitis) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases path(MESH:Encephalomyelitis) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases path(MESH:Paralysis) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases path(HP:"Limb muscle weakness") |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Il1b) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Il1b) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Il17a) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Il17a) |
| pmid:23383175 | a(CHEBI:Anatabine) causesNoChange p(MGI:Ifng) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Ifng) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Rela, pmod(Ph)) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases p(MGI:Rela, pmod(Ph)) |
| pmid:23383175 | a(CHEBI:Anatabine) causesNoChange bp(HBP:Astrogliosis) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases bp(HBP:Astrogliosis) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases bp(HBP:Microgliosis) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases tloc(a(MESH:Leukocytes), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases a(MESH:Microglia) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases tloc(a(MESH:Microglia), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) |
| pmid:23383175 | a(CHEBI:Anatabine) decreases tloc(a(MESH:Macrophages), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) |
| pmid:23383175 | a(CHEBI:Anatabine) positiveCorrelation a(GO:"myelin sheath") |
| pmid:23178521 | a(CHEBI:stattic) decreases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:stattic) decreases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:stattic) decreases complex(p(HGNC:STAT3), p(HGNC:STAT3)) |
| pmid:23178521 | a(CHEBI:stattic) decreases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph)) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(HGNC:IL1B) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) |
| pmid:23178521 | a(CHEBI:lipopolysaccharide) increases p(MGI:Stat3, pmod(Ph)) |
| pmid:23178521 | composite(a(CHEBI:Anatabine), a(MESH:Blood)) decreases p(HGNC:IL1B) |
| pmid:23178521 | composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide), a(MESH:Blood)) decreases p(HGNC:IL1B) |
| pmid:23383175 | p(MGI:Il1b) positiveCorrelation path(MESH:Encephalomyelitis) |
| pmid:23383175 | p(MGI:Il6) positiveCorrelation path(MESH:Encephalomyelitis) |
| pmid:23383175 | p(MGI:Tnf) positiveCorrelation path(MESH:Encephalomyelitis) |
| pmid:23178521 | composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il1b) |
| pmid:23178521 | composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il1b) |
| pmid:23178521 | composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf) |
| pmid:23178521 | composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf) |
| pmid:23178521 | composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf) |
| pmid:23178521 | composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il6) |
| pmid:23178521 | composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il6) |
| pmid:23383175 | p(MGI:Stat3, pmod(Ph)) positiveCorrelation path(MESH:Encephalomyelitis) |
| pmid:23383175 | p(MGI:Stat3, pmod(Ph)) positiveCorrelation path(MESH:Encephalomyelitis) |
| pmid:23383175 | p(MGI:Stat3, pmod(Ph)) positiveCorrelation path(MESH:Encephalomyelitis) |
| pmid:23383175 | p(MGI:Stat3, pmod(Ph)) association path(MESH:"Neurologic Manifestations") |
| pmid:23383175 | p(MGI:Stat3, pmod(Ph)) positiveCorrelation p(MGI:Rela, pmod(Ph)) |
| pmid:23383175 | p(MGI:Stat3) regulates bp(GO:"cytokine production") |
| pmid:23383175 | act(a(GO:axon)) decreases path(MESH:Paralysis) |
| pmid:23383175 | act(a(GO:axon)) decreases path(HP:"Limb muscle weakness") |
| pmid:23383175 | path(MESH:Encephalomyelitis) negativeCorrelation a(CHEBI:Anatabine) |
| pmid:23383175 | path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il1b) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases p(MGI:Il1b) |
| pmid:23383175 | path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Ifng) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases p(MGI:Ifng) |
| pmid:23383175 | path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Tnf) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases p(MGI:Tnf) |
| pmid:23383175 | path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il6) |
| pmid:23383175 | path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il17a) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases p(MGI:Rela, pmod(Ph)) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases bp(HBP:Astrogliosis) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases bp(HBP:Astrogliosis) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases bp(HBP:Microgliosis) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases tloc(a(MESH:Leukocytes), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) |
| pmid:23383175 | path(MESH:Encephalomyelitis) increases a(MESH:Microglia) |
| pmid:23383175 | path(MESH:Encephalomyelitis) decreases a(GO:"myelin sheath") |
| pmid:23383175 | p(MGI:Ifng) positiveCorrelation path(MESH:Encephalomyelitis) |
| pmid:23383175 | p(MGI:Il17a) positiveCorrelation path(MESH:Encephalomyelitis) |
| pmid:23383175 | p(MGI:Rela, pmod(Ph)) positiveCorrelation p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | p(MGI:Rela) regulates bp(GO:"cytokine production") |
| pmid:23383175 | path(MESH:"Neurologic Manifestations") association p(MGI:Stat3, pmod(Ph)) |
| pmid:23383175 | bp(HBP:Astrogliosis) negativeCorrelation a(GO:"myelin sheath") |
| pmid:23383175 | bp(HBP:Microgliosis) negativeCorrelation a(GO:"myelin sheath") |
| pmid:23383175 | a(GO:"myelin sheath") positiveCorrelation a(CHEBI:Anatabine) |
| pmid:23383175 | a(GO:"myelin sheath") negativeCorrelation a(MESH:Astrocytes) |
| pmid:23383175 | a(GO:"myelin sheath") negativeCorrelation a(MESH:Microglia) |
| pmid:23383175 | a(GO:"myelin sheath") negativeCorrelation bp(HBP:Astrogliosis) |
| pmid:23383175 | a(GO:"myelin sheath") negativeCorrelation bp(HBP:Microgliosis) |
| pmid:25437566 | a(CHEBI:ATP) association act(p(FPLX:HSP90)) |
| pmid:25437566 | a(CHEBI:ATP) association act(p(FPLX:HSPA)) |
| pmid:25437566 | a(CHEBI:ATP) association act(p(HGNC:HSPD1)) |
| pmid:24457024 | a(CHEBI:ATP) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) |
| pmid:24457024 | a(CHEBI:ATP) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome")) |
| pmid:27671637 | a(CHEBI:ATP) positiveCorrelation a(GO:mitochondrion) |
| pmid:24561250 | a(CHEBI:ATP) increases act(complex(GO:"inflammasome complex")) |
| pmid:24561250 | a(CHEBI:ATP) increases act(complex(GO:"inflammasome complex")) |
| pmid:24561250 | a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pmid:24561250 | a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pmid:24561250 | a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pmid:24561250 | a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pmid:25437566 | act(p(FPLX:HSP90)) association a(CHEBI:ATP) |
| pmid:25437566 | p(FPLX:HSP90) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:25437566 | p(FPLX:HSP90) increases bp(GO:"protein folding") |
| pmid:25784053 | p(FPLX:HSP90) regulates bp(GO:"protein folding") |
| pmid:29311797 | act(p(FPLX:HSP90)) increases bp(GO:"protein folding") |
| pmid:25784053 | p(FPLX:HSP90) isA a(MESH:"Molecular Chaperones") |
| pmid:25784053 | p(FPLX:HSP90) regulates bp(MESH:Proteolysis) |
| pmid:29311797 | act(p(FPLX:HSP90)) increases bp(MESH:Proteolysis) |
| pmid:25784053 | act(p(FPLX:HSP90)) decreases act(p(HGNC:HSF1)) |
| pmid:21882945 | act(p(FPLX:HSP90)) association a(CHEBI:celastrol) |
| pmid:21882945 | p(FPLX:HSP90) increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") |
| pmid:21882945 | p(FPLX:HSP90) increases bp(GO:"proteasomal protein catabolic process") |
| pmid:21882945 | p(FPLX:HSP90) increases bp(GO:autophagy) |
| pmid:21882945 | p(FPLX:HSP90) increases act(p(HGNC:STUB1)) |
| pmid:21882945 | p(FPLX:HSP90) increases bp(GO:"protein catabolic process") |
| pmid:21882945 | p(FPLX:HSP90) increases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:21882945 | p(FPLX:HSP90) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:21882945 | p(FPLX:HSP90) regulates p(HGNC:MAPT, pmod(Ph)) |
| pmid:21882945 | p(FPLX:HSP90) regulates act(p(HGNC:GSK3B)) |
| pmid:21882945 | p(FPLX:HSP90) regulates p(HGNC:MAPT, var("?")) |
| pmid:29311797 | p(FPLX:HSP90) increases p(HGNC:MAPT, var("?")) |
| pmid:29311797 | act(p(FPLX:HSP90)) decreases path(MESH:"Protein Aggregation, Pathological") |
| pmid:29311797 | p(FPLX:HSP90) regulates path(MESH:"Protein Aggregation, Pathological") |
| pmid:29311797 | act(p(FPLX:HSP90)) increases bp(GO:"protein modification process") |
| pmid:29311797 | p(FPLX:HSP90) regulates a(HBP:"Tau aggregates") |
| pmid:29311797 | p(FPLX:HSP90) association bp(HBP:Proteostasis) |
| pmid:29311797 | p(FPLX:HSP90) increases act(p(FPLX:Proteasome)) |
| pmid:29311797 | p(FPLX:HSP90) association bp(GO:"chaperone-mediated autophagy") |
| pmid:29311797 | act(p(FPLX:HSP90), ma(GO:"ATPase activity")) increases path(MESH:Tauopathies) |
| pmid:29311797 | p(FPLX:HSP90) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:25437566 | act(p(FPLX:HSPA)) association a(CHEBI:ATP) |
| pmid:14556719 | p(FPLX:HSPA) increases complex(p(HGNC:ATXN3, frag("?")), p(HGNC:PRKN)) |
| pmid:14556719 | p(FPLX:HSPA) increases a(HBP:"protein aggregates") |
| pmid:14556719 | p(FPLX:HSPA) increases bp(GO:"cell death") |
| pmid:25784053 | p(FPLX:HSPA) isA a(MESH:"Molecular Chaperones") |
| pmid:25784053 | p(FPLX:HSPA) regulates bp(GO:"protein folding") |
| pmid:25784053 | p(FPLX:HSPA) regulates bp(MESH:Proteolysis) |
| pmid:25784053 | p(FPLX:HSPA) positiveCorrelation path(MESH:"Huntington Disease") |
| pmid:29626319 | p(FPLX:HSPA) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:25437566 | act(p(HGNC:HSPD1)) association a(CHEBI:ATP) |
| pmid:25784053 | p(HGNC:HSPD1) isA a(MESH:"Molecular Chaperones") |
| pmid:25784053 | p(HGNC:HSPD1) increases bp(HBP:Proteostasis) |
| pmid:25784053 | p(HGNC:HSPD1) association bp(MESH:"Energy Metabolism") |
| pmid:25784053 | p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") isA a(MESH:"Molecular Chaperones") |
| pmid:25784053 | p(FPLX:HSPB) isA a(MESH:"Molecular Chaperones") |
| pmid:25437566 | p(HGNC:HSPA8) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:25437566 | p(HGNC:HSPA8) increases bp(GO:"protein folding") |
| pmid:25437566 | p(HGNC:HSPA8) increases a(HBP:"huntingtin aggregates") |
| pmid:21882945 | p(HGNC:HSPA8) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:21882945 | act(p(HGNC:HSPA8)) increases deg(p(HGNC:MAPT)) |
| pmid:18500754 | p(HGNC:HSPA8) association p(HBP:"microtubule-binding region") |
| pmid:18500754 | act(p(HGNC:HSPA8)) negativeCorrelation act(complex(GO:microtubule)) |
| pmid:25437566 | p(FPLX:"CCT_complex") decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:25437566 | p(FPLX:"CCT_complex") increases a(HBP:"huntingtin aggregates") |
| pmid:25784053 | p(FPLX:"CCT_complex") association a(MESH:"Cellular Structures") |
| pmid:25784053 | p(FPLX:"CCT_complex") association bp(GO:"cell division") |
| pmid:25784053 | p(FPLX:"CCT_complex") association bp(GO:"intracellular transport") |
| pmid:25784053 | p(FPLX:"CCT_complex") decreases act(p(HGNC:HSF1)) |
| pmid:25437566 | p(HGNC:DNAJA1) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:25437566 | p(HGNC:DNAJA1) increases bp(GO:"protein folding") |
| pmid:25437566 | p(HGNC:DNAJA1) increases a(HBP:"huntingtin aggregates") |
| pmid:25437566 | p(HGNC:STIP1) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:25036637 | p(HGNC:STIP1) increases complex(p(HGNC:STIP1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:29311797 | p(HGNC:STIP1) decreases p(HGNC:MAPT) |
| pmid:29311797 | p(HGNC:STIP1) association bp(GO:"chaperone-mediated autophagy") |
| pmid:25784053 | bp(GO:"protein folding") association bp(HBP:Proteostasis) |
| pmid:29311797 | bp(GO:"protein folding") association a(MESH:"Molecular Chaperones") |
| pmid:25437566 | p(HGNC:TTC1) increases bp(GO:"protein folding") |
| pmid:25437566 | p(HGNC:CCT5) causesNoChange a(HBP:"huntingtin aggregates") |
| pmid:25437566 | p(HGNC:DNAJA4) increases a(HBP:"huntingtin aggregates") |
| pmid:25437566 | p(HGNC:HSPA14) increases a(HBP:"huntingtin aggregates") |
| pmid:25437566 | p(HGNC:CDC23) increases a(HBP:"huntingtin aggregates") |
| pmid:25437566 | p(HGNC:CDC27) increases a(HBP:"huntingtin aggregates") |
| pmid:25036637 | p(HGNC:HSP90AB1) directlyIncreases complex(a(MESH:"Protein Kinases"), p(HGNC:HSP90AB1)) |
| pmid:29311797 | p(HGNC:HSP90AB1) association bp(GO:"embryo development") |
| pmid:29311797 | p(HGNC:HSP90AB1) association bp(GO:"cell maturation") |
| pmid:29311797 | p(HGNC:HSP90AB1) association bp(GO:"cytoskeleton organization") |
| pmid:29311797 | p(HGNC:HSP90AB1) association bp(GO:"signal transduction") |
| pmid:29311797 | p(HGNC:HSP90AB1) association bp(GO:"adaptation of signaling pathway") |
| pmid:14556719 | composite(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) |
| pmid:14556719 | act(p(HGNC:UBA1)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29626319 | p(HGNC:UBA1) increases deg(a(MESH:Proteins)) |
| pmid:14556719 | act(a(MESH:Ubiquitin)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) |
| pmid:24457024 | a(MESH:Ubiquitin) regulates bp(GO:signaling) |
| pmid:24457024 | a(MESH:Ubiquitin) regulates bp(GO:endocytosis) |
| pmid:24457024 | a(MESH:Ubiquitin) regulates bp(GO:macroautophagy) |
| pmid:24457024 | a(MESH:Ubiquitin) regulates bp(GO:"DNA repair") |
| pmid:24457024 | act(a(MESH:Ubiquitin)) regulates bp(GO:"cellular homeostasis") |
| pmid:24457024 | complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) |
| pmid:24457024 | complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) |
| pmid:14556719 | p(HGNC:UBA2) decreases complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) |
| pmid:14556719 | p(HGNC:UBA2) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) |
| pmid:14556719 | p(HGNC:UBA2) increases complex(a(MESH:Ubiquitin), p(INTERPRO:"HECT domain")) |
| pmid:14556719 | act(p(HGNC:UBA2)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:14556719 | p(HGNC:UBA2) increases p(HGNC:HTT, pmod(Ub)) |
| pmid:24457024 | p(HGNC:UBA2) increases bp(GO:"protein ubiquitination") |
| pmid:24457024 | complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) increases act(p(HGNC:UBA2)) |
| pmid:14556719 | p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") |
| pmid:14556719 | p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") |
| pmid:24457024 | p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") |
| pmid:24457024 | p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") |
| pmid:24457024 | p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") |
| pmid:14556719 | p(HGNC:UBA3) association bp(GO:proteolysis) |
| pmid:24457024 | p(HGNC:UBA3) increases act(p(HGNC:UBA2)) |
| pmid:24457024 | p(HGNC:UBA3) regulates complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) |
| pmid:24457024 | p(HGNC:UBA3) regulates bp(GO:"protein polyubiquitination") |
| pmid:24457024 | p(INTERPRO:"HECT domain") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) |
| pmid:14556719 | p(INTERPRO:"E3 ubiquitin ligase RBR family") decreases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) |
| pmid:14556719 | p(INTERPRO:"E3 ubiquitin ligase RBR family") increases complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA3)) |
| pmid:24457024 | p(INTERPRO:"E3 ubiquitin ligase RBR family") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) |
| pmid:24457024 | complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) increases act(p(HGNC:UBA2)) |
| pmid:24457024 | tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome")) increases act(p(HGNC:PSMD14)) |
| pmid:14556719 | bp(GO:"protein ubiquitination") increases bp(GO:"lysosomal protein catabolic process") |
| pmid:14556719 | bp(GO:"protein ubiquitination") increases bp(GO:"protein catabolic process in the vacuole") |
| pmid:14556719 | bp(GO:"protein ubiquitination") regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:14556719 | bp(GO:"protein K48-linked ubiquitination") increases act(complex(GO:"proteasome complex")) |
| pmid:14556719 | bp(GO:"protein K63-linked ubiquitination") increases act(complex(GO:"proteasome complex")) |
| pmid:14556719 | bp(GO:proteolysis) association p(HGNC:UBA3) |
| pmid:29626319 | bp(GO:proteolysis) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:14556719 | p(HGNC:MOCS3) increases bp(GO:"protein polyubiquitination") |
| pmid:16816118 | act(p(HBP:"20 S Proteasome")) negativeCorrelation p(RGD:Mapt, pmod(HBP:nitration)) |
| pmid:16816118 | act(p(HBP:"20 S Proteasome")) negativeCorrelation bp(GO:"neurofibrillary tangle assembly") |
| pmid:14556719 | complex(GO:"proteasome regulatory particle") increases bp(GO:"protein unfolding") |
| pmid:14556719 | p(HGNC:PSMD4) increases complex(a(MESH:Ubiquitin), p(HGNC:PSMD4)) |
| pmid:14556719 | p(HGNC:PSMD4) association p(HGNC:PRKN) |
| pmid:24457024 | p(HGNC:PSMD4) increases complex(a(GO:"proteasome complex"), p(MESH:Proteins, pmod(Ub))) |
| pmid:25036637 | p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMC1), p(HGNC:PSMD4)) |
| pmid:25036637 | p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMD4), p(HGNC:USP14)) |
| pmid:25036637 | p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMC1), p(HGNC:PSMD4)) |
| pmid:25036637 | p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMD2), p(HGNC:PSMD4)) |
| pmid:25036637 | p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PRPS2), p(HGNC:PSMD4)) |
| pmid:25036637 | p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMA5), p(HGNC:PSMD4)) |
| pmid:14556719 | p(HGNC:PSMC3) increases complex(a(MESH:Ubiquitin), p(HGNC:PSMC3)) |
| pmid:14556719 | deg(complex(a(MESH:Proteins), a(MESH:Ubiquitin))) increases a(MESH:Ubiquitin) |
| pmid:14556719 | deg(complex(a(MESH:Proteins), a(MESH:Ubiquitin))) increases a(CHEBI:peptide) |
| pmid:14556719 | complex(a(MESH:"Molecular Chaperones"), a(MESH:Proteins)) increases bp(GO:"protein stabilization") |
| pmid:25784053 | a(MESH:"Molecular Chaperones") decreases path(MESH:"Protein Aggregation, Pathological") |
| pmid:21882945 | a(MESH:"Molecular Chaperones") association bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") |
| pmid:29311797 | a(MESH:"Molecular Chaperones") association bp(GO:"protein folding") |
| pmid:29311797 | a(MESH:"Molecular Chaperones") association bp(MESH:Proteolysis) |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cell cycle") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cell division") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cell differentiation") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(MESH:"Cell Proliferation") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cellular response to stress") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates a(MESH:"Receptors, Cell Surface") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates a(MESH:"Ion Channels") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(MESH:"Secretory Pathway") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"DNA repair") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"gene silencing") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"long-term memory") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"circadian rhythm") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"immune response") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"inflammatory response") |
| pmid:14556719 | bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"organelle organization") |
| pmid:25784053 | bp(GO:"cell division") association p(FPLX:"CCT_complex") |
| pmid:21882945 | bp(GO:"cellular response to stress") increases a(MESH:"Heat-Shock Proteins") |
| pmid:21882945 | bp(GO:"cellular response to stress") increases a(HBP:"Hsp27 oligomers") |
| pmid:25036637 | bp(GO:"gene silencing") association p(HGNC:DCP1A) |
| pmid:25036637 | bp(GO:"gene silencing") association p(HGNC:EDC3) |
| pmid:25036637 | bp(GO:"gene silencing") association p(HGNC:DDX6) |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Parkinson Disease") |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:PARK7)) |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Prion Diseases") |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Prion Diseases") |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation bp(GO:aging) |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:PRNP)) |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SOD1, var("?"))) |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SOD1, var("?"))) |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SOD1, var("?"))) |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases a(HBP:"protein aggregates") |
| pmid:14556719 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:HTT, frag("?"))) |
| pmid:30116051 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:MAPT)) |
| pmid:23528736 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association deg(p(HGNC:MAPT)) |
| pmid:30116051 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"regulation of synaptic plasticity") |
| pmid:30116051 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"dendrite development") |
| pmid:30116051 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:memory) |
| pmid:23528736 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association a(HBP:"Tau aggregates") |
| pmid:29626319 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"cellular protein catabolic process") |
| pmid:29626319 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") regulates deg(a(MESH:Proteins)) |
| pmid:29626319 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases p(HBP:"Tau oligomers", pmod(HBP:hyperphosphorylation)) |
| pmid:14556719 | bp(GO:"protein catabolic process") increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:14556719 | path(MESH:Cachexia) increases bp(GO:"protein catabolic process") |
| pmid:14556719 | path(MESH:Sepsis) increases bp(GO:"protein catabolic process") |
| pmid:14556719 | path(MESH:Acidosis) increases bp(GO:"protein catabolic process") |
| pmid:14556719 | a(MESH:Denervation) increases bp(GO:"protein catabolic process") |
| pmid:14556719 | p(HGNC:NEDD8) increases complex(a(GO:"SCF ubiquitin ligase complex"), p(HGNC:UBA2)) |
| pmid:14556719 | p(HGNC:SUMO1) increases p(HGNC:NFKBIA, pmod(Sumo)) |
| pmid:27716675 | p(HGNC:SUMO1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23229893 | p(HGNC:SUMO1) partOf a(GO:lysosome) |
| pmid:19323834 | p(HGNC:SUMO1) partOf complex(p(FPLX:CEBP), p(HGNC:SUMO1)) |
| pmid:18675254 | p(HGNC:SUMO1) increases p(HGNC:APP, pmod(Sumo, Lys, 587)) |
| pmid:18675254 | p(HGNC:SUMO1) increases p(HGNC:APP, pmod(Sumo, Lys, 595)) |
| pmid:16464864 | p(HGNC:SUMO1) increases p(HGNC:MAPT, pmod(Sumo, Lys, 340)) |
| pmid:16464864 | p(HGNC:SUMO1) increases p(HGNC:SNCA, pmod(Sumo)) |
| pmid:14556719 | p(HGNC:NFKBIA, pmod(Sumo)) decreases bp(GO:"protein ubiquitination") |
| pmid:14556719 | p(UNIPROT:P32628) increases tloc(p(MESH:Proteins, pmod(Ub)), fromLoc(GO:cytosol), toLoc(GO:"proteasome complex")) |
| pmid:14556719 | p(UNIPROT:P48510) increases tloc(p(MESH:Proteins, pmod(Ub)), fromLoc(GO:cytosol), toLoc(GO:"proteasome complex")) |
| pmid:14556719 | complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(MESH:"Neurofibrillary Tangles") |
| pmid:14556719 | complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(GO:"Bunina body") |
| pmid:14556719 | complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Huntington Disease") |
| pmid:14556719 | complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Spinocerebellar Ataxias") |
| pmid:14556719 | complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") |
| pmid:14556719 | complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(MESH:"Lewy Bodies") |
| pmid:14556719 | a(MESH:"Inclusion Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders") |
| pmid:14556719 | a(MESH:"Inclusion Bodies") association p(HGNC:SNCA) |
| pmid:14556719 | a(MESH:"Inclusion Bodies") association p(HGNC:CREBBP) |
| pmid:14556719 | complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(MESH:"Neurofibrillary Tangles") |
| pmid:14556719 | complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(GO:"Bunina body") |
| pmid:14556719 | complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Huntington Disease") |
| pmid:14556719 | complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Spinocerebellar Ataxias") |
| pmid:14556719 | complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") |
| pmid:14556719 | complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(MESH:"Lewy Bodies") |
| pmid:14556719 | a(GO:"Bunina body") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) |
| pmid:14556719 | a(GO:"Bunina body") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) |
| pmid:14556719 | path(MESH:"Spinocerebellar Ataxias") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) |
| pmid:14556719 | path(MESH:"Spinocerebellar Ataxias") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) |
| pmid:14556719 | path(MESH:"Bulbo-Spinal Atrophy, X-Linked") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) |
| pmid:14556719 | path(MESH:"Bulbo-Spinal Atrophy, X-Linked") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) |
| pmid:14556719 | a(MESH:"Lewy Bodies") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) |
| pmid:14556719 | a(MESH:"Lewy Bodies") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) |
| pmid:14556719 | a(MESH:"Lewy Bodies") association a(GO:"dopaminergic synapse") |
| pmid:14556719 | a(MESH:"Lewy Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders") |
| pmid:14556719 | a(MESH:"Lewy Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders") |
| pmid:14556719 | a(MESH:"Lewy Bodies") association a(HBP:"alpha-synuclein aggregates") |
| pmid:14556719 | a(MESH:"Lewy Bodies") association path(MESH:"Parkinson Disease") |
| pmid:14556719 | a(HBP:"protein aggregates") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:14556719 | a(GO:"dopaminergic synapse") association a(MESH:"Lewy Bodies") |
| pmid:14556719 | p(HGNC:PRKN) positiveCorrelation path(MESH:"Parkinson Disease") |
| pmid:14556719 | p(HGNC:PRKN) association p(HGNC:PSMD4) |
| pmid:14556719 | p(HGNC:PRKN) association bp(MESH:"Synaptic Transmission") |
| pmid:14556719 | p(HGNC:PRKN) negativeCorrelation a(MESH:"Dopaminergic Neurons") |
| pmid:14556719 | p(HGNC:PRKN) increases p(HGNC:SEPT5, pmod(Ub)) |
| pmid:14556719 | p(HGNC:PRKN) association p(HGNC:GPR37) |
| pmid:14556719 | p(HGNC:PRKN) decreases bp(GO:"response to unfolded protein") |
| pmid:14556719 | p(HGNC:PRKN) decreases act(p(HGNC:SNCA)) |
| pmid:14556719 | p(HGNC:PRKN) regulates p(HGNC:SNCA) |
| pmid:14556719 | p(HGNC:PRKN) association p(HGNC:SNCA, pmod(OGlyco)) |
| pmid:14556719 | p(HGNC:PRKN) increases p(HGNC:SNCAIP, pmod(Ub)) |
| pmid:14556719 | p(HGNC:PRKN) increases p(HGNC:SNCAIP, pmod(Ub)) |
| pmid:14556719 | p(HGNC:PRKN) increases tloc(p(HGNC:SNCAIP, pmod(Ub)), fromLoc(GO:cytosol), toLoc(MESH:"Inclusion Bodies")) |
| pmid:14556719 | p(HGNC:PRKN) increases act(complex(GO:"proteasome complex")) |
| pmid:14556719 | p(HGNC:PRKN) decreases act(p(HGNC:CASP12)) |
| pmid:14556719 | p(HGNC:PRKN) association p(HGNC:CCNE1) |
| pmid:14556719 | p(HGNC:PRKN) decreases p(HGNC:CCNE1) |
| pmid:14556719 | p(HGNC:PRKN) decreases bp(GO:"neuron apoptotic process") |
| pmid:14556719 | p(HGNC:PRKN) decreases bp(GO:"cell death") |
| pmid:14556719 | p(HGNC:PRKN) increases p(HGNC:SYT11, pmod(Ub)) |
| pmid:14556719 | p(HGNC:PRKN) association a(GO:"actin filament") |
| pmid:14556719 | p(HGNC:PRKN) regulates act(a(MESH:Actins)) |
| pmid:14556719 | p(HGNC:PRKN) association p(HGNC:SNCA, pmod(Glyco)) |
| pmid:23528736 | p(HGNC:PRKN) association path(MESH:"Neurodegenerative Diseases") |
| pmid:14556719 | p(HGNC:PRKN, var("?")) increases path(MESH:"Parkinsonian Disorders") |
| pmid:14556719 | p(HGNC:PRKN, var("?")) decreases act(p(HGNC:PRKN)) |
| pmid:14556719 | p(HGNC:PRKN, var("?")) increases p(HGNC:PRKN) |
| pmid:14556719 | p(HGNC:PRKN, var("?")) decreases act(p(HGNC:SEPT5)) |
| pmid:14556719 | p(HGNC:PRKN, var("?")) causesNoChange deg(p(HGNC:SNCA)) |
| pmid:28803412 | p(HGNC:PRKN, var("?")) increases path(MESH:"Neurodegenerative Diseases") |
| pmid:30116051 | p(HGNC:PRKN, var("?")) association path(MESH:"Parkinson Disease") |
| pmid:30116051 | p(HGNC:PRKN, var("?")) decreases bp(GO:mitophagy) |
| pmid:30116051 | p(HGNC:PRKN, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:14556719 | path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Lewy Bodies") |
| pmid:14556719 | path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Lewy Bodies") |
| pmid:14556719 | path(MESH:"Parkinsonian Disorders") positiveCorrelation p(HGNC:GPR37) |
| pmid:14556719 | path(MESH:"Parkinsonian Disorders") association p(HGNC:SNCA, var("?")) |
| pmid:14556719 | path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Inclusion Bodies") |
| pmid:14556719 | path(MESH:"Parkinsonian Disorders") association p(HGNC:PRKN, var("p.Lys161Asn")) |
| pmid:14556719 | path(MESH:"Parkinsonian Disorders") positiveCorrelation a(HBP:"alpha-synuclein aggregates") |
| pmid:14556719 | path(MESH:"Parkinsonian Disorders") increases path(HBP:Neurodegeneration) |
| pmid:14556719 | path(MESH:"Parkinsonian Disorders") association g(HGNC:PARK7, var("?")) |
| pmid:14556719 | path(MESH:"Parkinsonian Disorders") association p(HGNC:PARK7, var("p.Leu166Pro")) |
| pmid:30126037 | path(MESH:"Parkinsonian Disorders") association path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:14556719 | p(HGNC:PRKN, var("p.Arg42")) decreases complex(a(GO:"proteasome complex"), p(HGNC:PRKN)) |
| pmid:14556719 | p(HGNC:PRKN, var("p.Arg42")) increases path(MESH:"Parkinsonian Disorders") |
| pmid:14556719 | complex(a(GO:"proteasome complex"), p(HGNC:PRKN)) decreases path(MESH:"Parkinsonian Disorders") |
| pmid:14556719 | complex(GO:"SCF ubiquitin ligase complex") increases p(HGNC:CCNE1, pmod(Ub)) |
| pmid:29121589 | p(HGNC:CUL1) partOf complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph))) |
| pmid:14556719 | p(INTERPRO:"IBR domain", var("?")) decreases act(p(HGNC:PRKN)) |
| pmid:14556719 | complex(p(HGNC:PRKN), p(HGNC:STUB1)) increases act(p(HGNC:PRKN)) |
| pmid:25036637 | p(HGNC:STUB1) increases complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(HGNC:STUB1) directlyIncreases complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:25036637 | p(HGNC:STUB1) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:STUB1)) |
| pmid:25036637 | p(HGNC:STUB1) regulates bp(GO:"cellular protein catabolic process") |
| pmid:24027553 | p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(Ub)) |
| pmid:23528736 | p(HGNC:STUB1) association path(MESH:"Neurodegenerative Diseases") |
| pmid:21882945 | act(p(HGNC:STUB1)) increases bp(GO:"protein catabolic process") |
| pmid:21882945 | act(p(HGNC:STUB1)) increases bp(GO:"protein ubiquitination") |
| pmid:29311797 | p(HGNC:STUB1) association path(MESH:"Huntington Disease") |
| pmid:29311797 | p(HGNC:STUB1) association path(MESH:"Parkinson Disease") |
| pmid:29311797 | p(HGNC:STUB1) association path(MESH:"Alzheimer Disease") |
| pmid:29311797 | p(HGNC:STUB1) association path(MESH:"Cystic Fibrosis") |
| pmid:29311797 | p(HGNC:STUB1) association path(MESH:Neoplasms) |
| pmid:29311797 | p(HGNC:STUB1) increases deg(p(HGNC:MAPT, pmod(Ph))) |
| pmid:29311797 | p(HGNC:STUB1) increases deg(p(HGNC:MAPT, pmod(HBP:misfolding))) |
| pmid:14612456 | p(HGNC:STUB1) isA complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) |
| pmid:17954934 | p(HGNC:STUB1) isA complex(p(HGNC:BAG1), p(HGNC:MAPT), p(HGNC:STUB1)) |
| pmid:25031639 | act(p(HGNC:STUB1)) negativeCorrelation a(HBP:"Tau epitope, 12E8") |
| pmid:25031639 | act(p(HGNC:STUB1)) increases deg(p(HGNC:MAPT)) |
| pmid:27325702 | p(HGNC:STUB1) association p(HBP:"APP, ACR") |
| pmid:27325702 | p(HGNC:STUB1) isA complex(GO:"ubiquitin ligase complex") |
| pmid:14556719 | p(HGNC:SEPT5) decreases sec(a(CHEBI:"growth hormone")) |
| pmid:14556719 | p(HGNC:SEPT5) regulates sec(a(CHEBI:neurotransmitter)) |
| pmid:14556719 | p(HGNC:SEPT5) regulates act(a(GO:"synaptic vesicle")) |
| pmid:14556719 | complex(p(HGNC:SEPT5), p(HGNC:STX1A)) decreases bp(GO:exocytosis) |
| pmid:14556719 | p(HGNC:GPR37) association p(HGNC:PRKN) |
| pmid:14556719 | p(HGNC:GPR37) increases p(HGNC:GPR37, pmod(HBP:misfolding)) |
| pmid:14556719 | p(HGNC:GPR37) positiveCorrelation bp(GO:"cell death") |
| pmid:14556719 | p(HGNC:GPR37) positiveCorrelation path(MESH:"Parkinsonian Disorders") |
| pmid:14556719 | bp(GO:"response to unfolded protein") increases bp(GO:"cell death") |
| pmid:14556719 | bp(GO:"response to unfolded protein") increases bp(GO:"response to endoplasmic reticulum stress") |
| pmid:14556719 | bp(GO:"response to unfolded protein") increases a(MESH:"Molecular Chaperones") |
| pmid:14556719 | bp(GO:"response to unfolded protein") positiveCorrelation bp(MESH:"Osmolar Concentration") |
| pmid:23702978 | bp(GO:"response to endoplasmic reticulum stress") increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:14556719 | p(MESH:Proteins, pmod(HBP:misfolding)) increases bp(GO:"response to unfolded protein") |
| pmid:24457024 | p(MESH:Proteins, pmod(HBP:misfolding)) increases bp(HBP:"protein aggregation") |
| pmid:14556719 | p(MESH:Proteins, var("?")) increases bp(GO:"response to unfolded protein") |
| pmid:14556719 | composite(p(HGNC:PRKN), p(HGNC:UBE2G1), p(HGNC:UBE2J1)) increases deg(p(HGNC:GPR37)) |
| pmid:14556719 | a(CHEBI:"hydrogen peroxide") increases bp(GO:"response to unfolded protein") |
| pmid:23531502 | act(a(CHEBI:"hydrogen peroxide")) positiveCorrelation bp(GO:"neurofibrillary tangle assembly") |
| pmid:23722080 | a(CHEBI:"hydrogen peroxide") increases bp(MESH:"Oxidative Stress") |
| pmid:23722080 | a(CHEBI:"hydrogen peroxide") positiveCorrelation composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) |
| pmid:14556719 | a(CHEBI:"alkylating agent") increases bp(GO:"response to unfolded protein") |
| pmid:14556719 | bp(MESH:"Ultraviolet Rays") increases bp(GO:"response to unfolded protein") |
| pmid:14556719 | bp(MESH:"Osmolar Concentration") positiveCorrelation bp(GO:"response to unfolded protein") |
| pmid:14556719 | bp(MESH:"Heat-Shock Response") increases bp(GO:"response to unfolded protein") |
| pmid:29807032 | bp(MESH:"Heat-Shock Response") association act(p(NCBIGENE:140621)) |
| pmid:29807032 | bp(MESH:"Heat-Shock Response") increases act(p(NCBIGENE:140621)) |
| pmid:29807032 | bp(MESH:"Heat-Shock Response") increases p(NCBIGENE:492507) |
| pmid:29807032 | bp(MESH:"Heat-Shock Response") causesNoChange p(NCBIGENE:492507) |
| pmid:29807032 | bp(MESH:"Heat-Shock Response") increases p(MESH:"corticotropin releasing factor-binding protein") |
| pmid:29807032 | bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") |
| pmid:29807032 | bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") |
| pmid:29807032 | bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") |
| pmid:14556719 | p(HGNC:SNCA) association p(HGNC:SNCAIP) |
| pmid:14556719 | p(HGNC:SNCA) regulates bp(GO:"dopamine secretion, neurotransmission") |
| pmid:14556719 | p(HGNC:SNCA) regulates bp(GO:"dopamine secretion") |
| pmid:14556719 | p(HGNC:SNCA) positiveCorrelation bp(HBP:"Alpha-synuclein Oligomerization") |
| pmid:14556719 | p(HGNC:SNCA) increases bp(GO:"apoptotic process") |
| pmid:14556719 | act(p(HGNC:SNCA)) increases p(HGNC:SNCAIP, pmod(Ub)) |
| pmid:14556719 | act(p(HGNC:SNCA)) increases p(HGNC:TH, pmod(Ub)) |
| pmid:14556719 | act(p(HGNC:SNCA)) regulates bp(GO:"homeostatic process") |
| pmid:14556719 | p(HGNC:SNCA) association a(MESH:"Inclusion Bodies") |
| pmid:25784053 | p(HGNC:SNCA) decreases bp(GO:autophagy) |
| pmid:25784053 | p(HGNC:SNCA) decreases p(HGNC:RAB1A) |
| pmid:28803412 | p(HGNC:SNCA) association path(MESH:"Parkinson Disease") |
| pmid:14556719 | p(HGNC:SNCA, pmod(OGlyco)) association p(HGNC:PRKN) |
| pmid:14556719 | p(HGNC:SNCA, var("?")) association path(MESH:"Parkinsonian Disorders") |
| pmid:14556719 | p(HGNC:SNCA, var("?")) increases bp(GO:"apoptotic process") |
| pmid:30116051 | p(HGNC:SNCA, var("?")) decreases bp(GO:"autophagosome assembly") |
| pmid:30116051 | p(HGNC:SNCA, var("?")) decreases a(GO:"lysosomal membrane") |
| pmid:14556719 | p(HGNC:SNCAIP) association p(HGNC:SNCA) |
| pmid:14556719 | composite(p(HGNC:SNCA), p(HGNC:SNCAIP)) increases a(MESH:"Inclusion Bodies") |
| pmid:14556719 | p(HGNC:ATXN3, frag("?")) decreases act(complex(GO:"proteasome complex")) |
| pmid:14556719 | p(HGNC:ATXN3, frag("?")) increases act(p(HGNC:CASP12)) |
| pmid:14556719 | p(HGNC:ATXN3) increases complex(p(HGNC:ATXN3), p(HGNC:RAD23A)) |
| pmid:14556719 | p(HGNC:CCNE1) association p(HGNC:PRKN) |
| pmid:14556719 | p(HGNC:CCNE1) positiveCorrelation bp(GO:"neuron apoptotic process") |
| pmid:14556719 | composite(a(PUBCHEM:164810), p(HGNC:PRKN)) decreases p(HGNC:CCNE1) |
| pmid:14556719 | bp(GO:"neuron apoptotic process") positiveCorrelation p(HGNC:CCNE1) |
| pmid:14963027 | bp(GO:"neuron apoptotic process") negativeCorrelation p(HGNC:HSPB1) |
| pmid:27068745 | bp(GO:"neuron apoptotic process") positiveCorrelation p(HGNC:UNC5C) |
| pmid:14556719 | p(HGNC:AIMP2) increases bp(GO:"cell death") |
| pmid:14556719 | p(HGNC:PRKN, var("p.Lys161Asn")) association path(MESH:"Parkinsonian Disorders") |
| pmid:14556719 | p(HGNC:PRKN, var("p.Lys161Asn")) increases p(HGNC:AIMP2, pmod(Ub)) |
| pmid:14556719 | p(HGNC:SYT11, pmod(Ub)) association bp(GO:"synaptic vesicle transport") |
| pmid:14556719 | p(HGNC:SYT11, pmod(Ub)) association sec(a(CHEBI:neurotransmitter)) |
| pmid:14556719 | bp(GO:"synaptic vesicle transport") association p(HGNC:SYT11, pmod(Ub)) |
| pmid:14556719 | a(GO:"actin filament") association p(HGNC:PRKN) |
| pmid:14556719 | p(HGNC:UBE3A) increases complex(a(HBP:"protein aggregates"), a(MESH:Neurons)) |
| pmid:14556719 | act(p(HGNC:UBE3A)) decreases bp(GO:"cell death") |
| pmid:14556719 | p(HGNC:UCHL1, var("?")) association path(MESH:"Parkinson Disease") |
| pmid:14556719 | p(HGNC:UCHL1, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:23528736 | p(HGNC:UCHL1, var("?")) association path(MESH:"Neurodegenerative Diseases") |
| pmid:23528736 | p(HGNC:UCHL1, var("?")) association path(MESH:"Alzheimer Disease") |
| pmid:14556719 | p(HGNC:UCHL1) decreases bp(GO:"protein ubiquitination") |
| pmid:14556719 | p(HGNC:UCHL1) increases p(HGNC:SNCA, pmod(Ub)) |
| pmid:14556719 | p(HGNC:UCHL1) decreases path(MESH:"Deglutition Disorders") |
| pmid:14556719 | p(HGNC:UCHL1) positiveCorrelation a(MESH:"Solitary Nucleus") |
| pmid:14556719 | p(HGNC:UCHL1) positiveCorrelation a(MESH:"Area Postrema") |
| pmid:14556719 | p(HGNC:UCHL1, var("p.Ile93Met")) association path(MESH:"Parkinson Disease") |
| pmid:14556719 | complex(p(HGNC:UCHL1), p(HGNC:UCHL1)) increases bp(GO:"protein K63-linked ubiquitination") |
| pmid:14556719 | p(HGNC:UCHL3) decreases path(MESH:"Deglutition Disorders") |
| pmid:14556719 | p(HGNC:UCHL3) positiveCorrelation a(MESH:"Solitary Nucleus") |
| pmid:14556719 | p(HGNC:UCHL3) positiveCorrelation a(MESH:"Area Postrema") |
| pmid:14556719 | a(MESH:"Solitary Nucleus") positiveCorrelation p(HGNC:UCHL1) |
| pmid:14556719 | a(MESH:"Solitary Nucleus") positiveCorrelation p(HGNC:UCHL3) |
| pmid:14556719 | a(MESH:"Area Postrema") positiveCorrelation p(HGNC:UCHL1) |
| pmid:14556719 | a(MESH:"Area Postrema") positiveCorrelation p(HGNC:UCHL3) |
| pmid:14556719 | bp(HBP:"Alpha-synuclein Oligomerization") positiveCorrelation p(HGNC:SNCA) |
| pmid:14556719 | bp(HBP:"Alpha-synuclein Oligomerization") increases a(HBP:"alpha-synuclein fibrils") |
| pmid:14556719 | a(HBP:"alpha-synuclein fibrils") increases a(HBP:"alpha-synuclein aggregates") |
| pmid:14556719 | a(HBP:"alpha-synuclein aggregates") association a(MESH:"Lewy Bodies") |
| pmid:14556719 | a(HBP:"alpha-synuclein aggregates") positiveCorrelation path(MESH:"Parkinsonian Disorders") |
| pmid:14556719 | a(HBP:"alpha-synuclein aggregates") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:14556719 | p(HGNC:SNCA, var("p.Ala30Pro")) association path(MESH:"Parkinson Disease") |
| pmid:28803412 | p(HGNC:SNCA, var("p.Ala30Pro")) increases path(MESH:"Parkinson Disease") |
| pmid:14556719 | p(HGNC:SNCA, var("p.Ala30Pro")) increases a(HBP:"alpha-synuclein fibrils") |
| pmid:28803412 | p(HGNC:SNCA, var("p.Ala30Pro")) increases path(MESH:"Lewy Body Disease") |
| pmid:14556719 | p(HGNC:SNCA, var("p.Ala53Thr")) association path(MESH:"Parkinson Disease") |
| pmid:28803412 | p(HGNC:SNCA, var("p.Ala53Thr")) increases path(MESH:"Parkinson Disease") |
| pmid:14556719 | p(HGNC:SNCA, var("p.Ala53Thr")) increases a(HBP:"alpha-synuclein fibrils") |
| pmid:14556719 | p(HGNC:SNCA, pmod(Glyco)) association p(HGNC:PRKN) |
| pmid:14556719 | complex(a(HBP:"alpha-synuclein aggregates"), p(HGNC:PSMC4)) decreases act(complex(GO:"proteasome complex")) |
| pmid:14556719 | complex(p(HGNC:PSMC4), p(HGNC:SNCA)) decreases act(complex(GO:"proteasome complex")) |
| pmid:14556719 | g(HGNC:PARK7, var("?")) association path(MESH:"Parkinsonian Disorders") |
| pmid:14556719 | p(HGNC:PARK7, pmod(Sumo)) regulates act(p(HGNC:PARK7)) |
| pmid:14556719 | complex(p(HGNC:PARK7), p(HGNC:PIAS2)) increases p(HGNC:PARK7, pmod(Sumo)) |
| pmid:14556719 | p(HGNC:PARK7, var("p.Leu166Pro")) association path(MESH:"Parkinsonian Disorders") |
| pmid:14556719 | p(HGNC:PARK7, var("p.Leu166Pro")) increases deg(p(HGNC:PARK7)) |
| pmid:14556719 | p(HGNC:CFTR, var("p.Phe508del")) increases deg(p(HGNC:CFTR)) |
| pmid:14556719 | p(HGNC:CFTR, var("p.Phe508del")) increases path(MESH:"Cystic Fibrosis") |
| pmid:29311797 | path(MESH:"Cystic Fibrosis") association p(HGNC:STUB1) |
| pmid:29311797 | path(MESH:"Cystic Fibrosis") association p(HGNC:AHSA1) |
| pmid:14556719 | bp(GO:"ERAD pathway") regulates deg(p(HGNC:CFTR)) |
| pmid:14556719 | bp(GO:"ERAD pathway") increases deg(p(HGNC:PRNP, pmod(HBP:misfolding))) |
| pmid:24457024 | bp(GO:"ERAD pathway") association complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(HBP:misfolding))) |
| pmid:14556719 | p(HGNC:SEC61A1) increases tloc(p(MESH:Proteins, pmod(HBP:misfolding)), fromLoc(GO:"endoplasmic reticulum lumen"), toLoc(GO:cytosol)) |
| pmid:14556719 | complex(GO:"gamma-secretase complex") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta polypeptide 40"), a(CHEBI:"amyloid-beta polypeptide 42"))) |
| pmid:14556719 | act(complex(GO:"gamma-secretase complex")) association p(HGNC:PSEN1, var("?")) |
| pmid:14556719 | act(complex(GO:"gamma-secretase complex")) association p(HGNC:PSEN2, var("?")) |
| pmid:14556719 | a(GO:microtubule) association p(HGNC:MAPT) |
| pmid:8282104 | a(GO:microtubule) association p(HGNC:CDK5) |
| pmid:8282104 | a(GO:microtubule) association p(HGNC:PRKACA) |
| pmid:8282104 | a(GO:microtubule) association p(FPLX:ERK) |
| pmid:8282104 | a(GO:microtubule) association p(FPLX:GSK3) |
| pmid:23487739 | a(GO:microtubule) negativeCorrelation act(p(HGNC:HDAC6)) |
| pmid:14556719 | g(HGNC:MAPT, var("?")) increases path(MESH:"Pick Disease of the Brain") |
| pmid:27574109 | path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"3R tau") |
| pmid:27574109 | path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"4R tau") |
| pmid:27574109 | path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT) |
| pmid:27574109 | path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT) |
| pmid:27574109 | path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:27574109 | path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:27574109 | path(MESH:"Pick Disease of the Brain") positiveCorrelation composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) |
| pmid:29311797 | path(MESH:"Pick Disease of the Brain") isA path(MESH:Tauopathies) |
| pmid:26195256 | path(MESH:"Pick Disease of the Brain") association path(MESH:"Alzheimer Disease") |
| pmid:27260836 | path(MESH:"Pick Disease of the Brain") positiveCorrelation complex(GO:"Pick body") |
| pmid:22057784 | path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) |
| pmid:22057784 | path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) |
| pmid:22057784 | path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(NO, Tyr, 29)) |
| pmid:14556719 | composite(a(CHEBI:"amyloid-beta"), p(HGNC:MAPT, var("?"))) increases path(MESH:"Alzheimer Disease") |
| pmid:14556719 | a(CHEBI:lactacystin) decreases act(complex(GO:"proteasome complex")) |
| pmid:14556719 | a(CHEBI:lactacystin) increases bp(GO:"cell death") |
| pmid:24027553 | a(CHEBI:lactacystin) decreases deg(p(HGNC:MAPT)) |
| pmid:24027553 | a(CHEBI:lactacystin) increases p(HGNC:MAPT) |
| pmid:23528736 | a(CHEBI:lactacystin) decreases deg(p(HGNC:MAPT)) |
| pmid:24027553 | a(CHEBI:lactacystin) increases p(HGNC:MAPT, var("p.P301L")) |
| pmid:24027553 | a(CHEBI:lactacystin) decreases act(p(HGNCGENEFAMILY:Proteasome)) |
| pmid:23528736 | a(CHEBI:lactacystin) decreases act(p(FPLX:Proteasome)) |
| pmid:14556719 | a(HBP:"paired helical filaments") decreases act(complex(GO:"proteasome complex")) |
| pmid:16566606 | a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) |
| pmid:16566606 | a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) |
| pmid:16566606 | a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) |
| pmid:16566606 | a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) |
| pmid:7667312 | a(HBP:"paired helical filaments") positiveCorrelation a(HBP:"Thioflavin S") |
| pmid:7667312 | a(HBP:"paired helical filaments") partOf complex(GO:"neurofibrillary tangle") |
| pmid:8391280 | a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(Ub, Lys, 254)) |
| pmid:8391280 | a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(Ub, Lys, 257)) |
| pmid:8391280 | a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(Ub, Lys, 311)) |
| pmid:14556719 | a(MESH:Prions) increases path(MESH:"Prion Diseases") |
| pmid:14556719 | a(MESH:Prions) increases path(MESH:"Encephalopathy, Bovine Spongiform") |
| pmid:14556719 | path(MESH:"Prion Diseases") increases path(MESH:"Motor Disorders") |
| pmid:14556719 | path(MESH:"Prion Diseases") increases path(MESH:Dementia) |
| pmid:14556719 | path(MESH:"Prion Diseases") increases path(MESH:Death) |
| pmid:14556719 | path(MESH:"Prion Diseases") increases bp(GO:"neuron death") |
| pmid:14556719 | path(MESH:"Prion Diseases") increases path(MESH:Gliosis) |
| pmid:14556719 | path(MESH:"Prion Diseases") increases a(HBP:"amyloid-beta aggregates") |
| pmid:14556719 | path(MESH:"Prion Diseases") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:14556719 | path(MESH:"Prion Diseases") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:14556719 | complex(p(HGNC:HSPA5), p(HGNC:PRNP)) increases bp(GO:"protein folding") |
| pmid:14556719 | p(HGNC:SOD1, var("?")) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:14556719 | p(HGNC:SOD1, var("?")) increases bp(GO:"response to oxidative stress") |
| pmid:14556719 | p(HGNC:SOD1, var("?")) increases bp(GO:"response to oxidative stress") |
| pmid:14556719 | p(HGNC:SOD1, var("?")) increases bp(GO:"cell death") |
| pmid:14556719 | p(HGNC:SOD1, var("?")) negativeCorrelation act(complex(GO:"proteasome complex")) |
| pmid:14556719 | p(HGNC:SOD1, var("?")) increases act(complex(GO:"proteasome complex")) |
| pmid:14556719 | p(HGNC:SOD1) decreases bp(GO:"response to oxidative stress") |
| pmid:14556719 | p(HGNC:SOD1, pmod(HBP:misfolding)) increases a(HBP:"protein aggregates") |
| pmid:14556719 | p(HGNC:RNF19A) decreases bp(GO:"cell death") |
| pmid:14556719 | p(HGNC:RNF19A) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:14556719 | p(HGNC:RNF19A) increases deg(p(HGNC:SOD1, var("?"))) |
| pmid:14556719 | p(HGNC:UBL5) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:14556719 | composite(a(CHEBI:lactacystin), p(HGNC:SOD1, var("?"))) increases bp(GO:"cell death") |
| pmid:14556719 | p(HGNC:HTT, var("?")) increases path(MESH:"Huntington Disease") |
| pmid:14556719 | p(HGNC:HTT, var("?")) increases a(HBP:"huntingtin aggregates") |
| pmid:14556719 | p(HGNC:HTT, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:14556719 | p(HGNC:HTT, var("?")) decreases act(p(HBP:"20 S Proteasome")) |
| pmid:14556719 | p(HGNC:HTT, var("?")) decreases deg(p(HGNC:TP53)) |
| pmid:14556719 | p(HGNC:HTT, var("?")) decreases bp(MESH:"Membrane Potential, Mitochondrial") |
| pmid:14556719 | p(HGNC:HTT, var("?")) increases sec(a(CHEBI:"cytochrome c")) |
| pmid:14556719 | p(HGNC:HTT, var("?")) increases act(p(FPLX:Caspase)) |
| pmid:14556719 | p(HGNC:HTT, var("?")) increases bp(GO:"apoptotic process") |
| pmid:25784053 | p(HGNC:HTT, var("?")) increases p(FPLX:HSPA) |
| pmid:30116051 | p(HGNC:HTT, var("?")) decreases bp(GO:autophagy) |
| pmid:30116051 | p(HGNC:HTT, var("?")) decreases bp(GO:"cargo loading into vesicle") |
| pmid:30116051 | p(HGNC:HTT, var("?")) decreases bp(GO:"autophagosome assembly") |
| pmid:14556719 | p(HGNC:HTT) increases complex(p(HGNC:HTT), p(HGNC:UBA2)) |
| pmid:14556719 | p(HGNC:HTT) decreases act(complex(GO:"proteasome complex")) |
| pmid:14556719 | p(HGNC:HTT) increases bp(GO:"cell cycle arrest") |
| pmid:14556719 | p(HGNC:CREBBP) association a(MESH:"Inclusion Bodies") |
| pmid:14556719 | p(HGNC:CDC34, var("?")) decreases a(MESH:"Inclusion Bodies") |
| pmid:14556719 | p(HGNC:CDC34, var("?")) increases bp(GO:"cell death") |
| pmid:24457024 | p(HGNC:CDC34) increases complex(a(MESH:Ubiquitin), p(HGNC:CDC34)) |
| pmid:14556719 | p(HGNC:RAD23A) increases tloc(p(HGNC:ATXN3, pmod(Ub)), fromLoc(GO:cytosol), toLoc(GO:"proteasome complex")) |
| pmid:28803412 | bp(GO:autophagy) increases a(HBP:HBP00093) |
| pmid:30116051 | bp(GO:autophagy) negativeCorrelation g(HGNC:PSEN1, var("?")) |
| pmid:30116051 | bp(GO:autophagy) increases deg(p(HGNC:HTT, var("?"))) |
| pmid:24027553 | bp(GO:autophagy) association p(HGNC:NPEPPS) |
| pmid:24027553 | bp(GO:autophagy) association deg(p(HGNC:MAPT)) |
| pmid:23528736 | bp(GO:autophagy) increases deg(p(HGNC:MAPT)) |
| pmid:29626319 | bp(GO:autophagy) increases deg(p(HGNC:MAPT)) |
| pmid:29626319 | bp(GO:autophagy) increases deg(p(HGNC:MAPT)) |
| pmid:26195256 | bp(GO:autophagy) decreases p(HGNC:APP) |
| pmid:29626319 | bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(Ph))) |
| pmid:23702978 | bp(GO:autophagy) regulates bp(GO:"apoptotic process") |
| pmid:23702978 | bp(GO:autophagy) regulates complex(GO:"inflammasome complex") |
| pmid:23702978 | bp(GO:autophagy) decreases act(complex(GO:"inflammasome complex")) |
| pmid:23702978 | bp(GO:autophagy) decreases sec(p(HGNC:IL1B)) |
| pmid:14556719 | composite(a(CHEBI:cystamine), p(HGNC:ATN1)) decreases a(HBP:"protein aggregates") |
| pmid:14556719 | composite(a(CHEBI:cystamine), p(HGNC:ATN1)) decreases bp(GO:"cell death") |
| pmid:14556719 | composite(a(CHEBI:cystamine), p(HGNC:AR, var("?"))) decreases a(HBP:"protein aggregates") |
| pmid:14556719 | composite(a(CHEBI:cystamine), p(HGNC:AR, var("?"))) decreases bp(GO:"cell death") |
| pmid:14556719 | a(CHEBI:"Congo Red") decreases a(HBP:"huntingtin aggregates") |
| pmid:14556719 | a(CHEBI:"Congo Red") increases act(complex(GO:"proteasome complex")) |
| pmid:29626319 | p(FPLX:Caspase) increases deg(p(HGNC:MAPT)) |
| pmid:24457024 | complex(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) |
| pmid:24457024 | complex(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) |
| pmid:24457024 | complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA2), p(HGNC:UBA3)) increases bp(GO:"protein ubiquitination") |
| pmid:29590627 | bp(GO:endocytosis) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | bp(GO:endocytosis) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | bp(GO:endocytosis) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:28420982 | bp(GO:endocytosis) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:endosome), toLoc(GO:lysosome)) |
| pmid:29686391 | bp(GO:endocytosis) positiveCorrelation bp(GO:"mitotic G1 phase") |
| pmid:25784053 | bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:30116051 | bp(GO:macroautophagy) increases deg(p(HGNC:MAPT, pmod(HBP:HBP00007))) |
| pmid:29024336 | bp(GO:macroautophagy) increases deg(p(MGI:Mapt)) |
| pmid:29024336 | bp(GO:macroautophagy) decreases deg(p(MGI:Mapt)) |
| pmid:29024336 | bp(GO:macroautophagy) increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) |
| pmid:29024336 | bp(GO:macroautophagy) decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) |
| pmid:29024336 | bp(GO:macroautophagy) causesNoChange deg(p(MGI:Mapt, var("p.Pro301Leu"))) |
| pmid:29024336 | bp(GO:macroautophagy) increases deg(a(MESH:Proteins)) |
| pmid:26751493 | bp(GO:macroautophagy) decreases p(HGNC:MAPT) |
| pmid:24457024 | p(HGNC:UBE2K) increases complex(a(MESH:Ubiquitin), p(HGNC:UBE2K)) |
| pmid:24457024 | p(HGNC:UBE2S) increases complex(a(MESH:Ubiquitin), p(HGNC:UBE2S)) |
| pmid:24457024 | path(MESH:"RING Finger Domains") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) |
| pmid:24457024 | p(INTERPRO:"U box domain") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) |
| pmid:24457024 | complex(a(MESH:Ubiquitin), p(MESH:Proteins, pmod(HBP:misfolding))) increases deg(p(MESH:Proteins, pmod(HBP:misfolding))) |
| pmid:24457024 | p(HGNC:VCP) increases bp(GO:"proteasomal protein catabolic process") |
| pmid:24457024 | p(HGNC:VCP) increases bp(GO:"protein ubiquitination") |
| pmid:24027553 | bp(GO:"proteasomal protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29626319 | bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT)) |
| pmid:24457024 | p(HGNC:BAG6) increases complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(HBP:misfolding))) |
| pmid:24457024 | complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(HBP:misfolding))) association bp(GO:"ERAD pathway") |
| pmid:24457024 | complex(p(HGNC:BAG6), p(HGNC:UBA3)) increases deg(p(MESH:Proteins, pmod(HBP:misfolding))) |
| pmid:24457024 | complex(p(HGNC:BAG6), p(HGNC:UBA3)) increases bp(GO:"protein ubiquitination") |
| pmid:24457024 | complex(p(HGNC:BAG6), p(HGNC:UBA3)) decreases bp(HBP:"protein aggregation") |
| pmid:24457024 | complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) increases deg(p(MESH:Proteins, pmod(HBP:misfolding))) |
| pmid:24457024 | complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) decreases bp(HBP:"protein aggregation") |
| pmid:24457024 | complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) increases bp(GO:"protein ubiquitination") |
| pmid:24457024 | a(MESH:"Deubiquitinating Enzymes") decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) |
| pmid:24457024 | complex(a(GO:"proteasome complex"), p(HGNC:UCHL5)) increases bp(GO:"protein catabolic process") |
| pmid:24457024 | complex(a(GO:"proteasome complex"), p(HGNC:USP14)) increases bp(GO:"protein catabolic process") |
| pmid:24457024 | complex(a(GO:"proteasome complex"), p(HGNC:USP14)) decreases bp(GO:"protein catabolic process") |
| pmid:25784053 | p(HGNC:USP14) decreases deg(p(HGNC:MAPT)) |
| pmid:25784053 | p(HGNC:USP14) decreases deg(p(HGNC:TARDBP)) |
| pmid:25784053 | p(HGNC:USP14) decreases act(p(FPLX:Proteasome)) |
| pmid:26041011 | act(p(HGNC:USP14)) decreases act(complex(GO:"proteasome complex")) |
| pmid:24457024 | act(p(HGNC:USP6)) decreases path(MESH:Aneuploidy) |
| pmid:24457024 | p(HGNC:ADRM1) increases complex(a(GO:"proteasome complex"), p(MESH:Proteins, pmod(Ub))) |
| pmid:25036637 | p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMA5)) |
| pmid:25036637 | p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMC1)) |
| pmid:25036637 | p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMD1)) |
| pmid:25036637 | p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMD4)) |
| pmid:24457024 | p(HGNC:PSMD14) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) |
| pmid:24457024 | p(HGNC:PSMD14) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) |
| pmid:24457024 | act(p(HGNC:PSMD14)) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome")) |
| pmid:24457024 | complex(a(GO:"proteasome complex"), a(MESH:Proteins)) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome")) |
| pmid:25784053 | bp(HBP:Proteostasis) association bp(MESH:"Protein Biosynthesis") |
| pmid:25784053 | bp(HBP:Proteostasis) association bp(GO:"protein folding") |
| pmid:25784053 | bp(HBP:Proteostasis) association path(MESH:"Protein Aggregation, Pathological") |
| pmid:25784053 | bp(HBP:Proteostasis) association bp(MESH:Proteolysis) |
| pmid:25784053 | bp(HBP:Proteostasis) decreases bp(MESH:Aging) |
| pmid:21882945 | bp(HBP:Proteostasis) regulates p(HGNC:MAPT) |
| pmid:21882945 | bp(HBP:Proteostasis) regulates a(MESH:Proteins) |
| pmid:29311797 | bp(HBP:Proteostasis) association p(FPLX:HSP90) |
| pmid:25784053 | bp(MESH:"Protein Biosynthesis") association bp(HBP:Proteostasis) |
| pmid:25784053 | path(MESH:"Protein Aggregation, Pathological") association bp(HBP:Proteostasis) |
| pmid:25784053 | path(MESH:"Protein Aggregation, Pathological") association path(MESH:"Neurodegenerative Diseases") |
| pmid:25784053 | path(MESH:"Protein Aggregation, Pathological") negativeCorrelation p(HGNC:HSPA1A) |
| pmid:25784053 | path(MESH:"Protein Aggregation, Pathological") negativeCorrelation p(HGNC:HSPA1B) |
| pmid:25784053 | path(MESH:"Protein Aggregation, Pathological") negativeCorrelation p(HGNC:DNAJB1) |
| pmid:27574109 | path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"3R tau") |
| pmid:27574109 | path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"3R tau") |
| pmid:27574109 | path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"4R tau") |
| pmid:27574109 | path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"4R tau") |
| pmid:27574109 | path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"Tau isoform F (441 aa)") |
| pmid:25784053 | bp(MESH:Proteolysis) association bp(HBP:Proteostasis) |
| pmid:29311797 | bp(MESH:Proteolysis) association a(MESH:"Molecular Chaperones") |
| pmid:25784053 | bp(MESH:"Growth and Development") regulates bp(HBP:Proteostasis) |
| pmid:25784053 | bp(GO:"ATP metabolic process") increases act(p(FPLX:HSPA)) |
| pmid:25784053 | bp(GO:"ATP metabolic process") increases act(p(FPLX:HSP90)) |
| pmid:29311797 | bp(GO:"ATP metabolic process") increases act(p(FPLX:HSP90)) |
| pmid:25784053 | complex(p(FPLX:HSPA), p(HGNC:DNAJB1), p(HGNC:HSPH1)) decreases path(MESH:"Protein Aggregation, Pathological") |
| pmid:25784053 | p(HGNC:DNAJB1) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pmid:25036637 | p(HGNC:DNAJB1) increases complex(p(HGNC:DNAJB1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:21882945 | p(HGNC:HSPH1) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:25784053 | a(MESH:"Cellular Structures") association p(FPLX:"CCT_complex") |
| pmid:25784053 | bp(GO:"intracellular transport") association p(FPLX:"CCT_complex") |
| pmid:25784053 | p(FPLX:Proteasome) increases bp(MESH:Proteolysis) |
| pmid:25784053 | p(FPLX:Proteasome) decreases path(MESH:"Protein Aggregation, Pathological") |
| pmid:25784053 | act(p(FPLX:Proteasome)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25784053 | a(MESH:Lysosomes) increases bp(MESH:Proteolysis) |
| pmid:25784053 | a(MESH:Lysosomes) decreases path(MESH:"Protein Aggregation, Pathological") |
| pmid:24027553 | a(MESH:Lysosomes) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29238289 | act(a(MESH:Lysosomes)) decreases p(HGNC:MAPT) |
| pmid:25784053 | bp(GO:"response to misfolded protein") increases act(p(HGNC:HSF1)) |
| pmid:25784053 | bp(GO:"response to misfolded protein") increases act(p(HGNC:ERN1), ma(kin)) |
| pmid:25784053 | act(p(HGNC:HSF1)) increases tloc(p(HGNC:HSF1), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) |
| pmid:25784053 | act(p(HGNC:HSF1), ma(tscript)) increases a(MESH:"Molecular Chaperones") |
| pmid:25784053 | act(p(HGNC:HSF1)) association path(MESH:Neoplasms) |
| pmid:30116051 | act(p(HGNC:HSF1), ma(tscript)) increases act(p(FPLX:HSPA)) |
| pmid:21882945 | p(HGNC:HSF1) increases a(MESH:"Heat-Shock Proteins") |
| pmid:21882945 | p(HGNC:HSF1) increases bp(HBP:Proteostasis) |
| pmid:25784053 | p(HGNC:HSF1, pmod(Ac)) decreases act(p(HGNC:HSF1)) |
| pmid:25784053 | complex(a(MESH:"Molecular Chaperones"), p(HGNC:HSF1)) decreases act(p(HGNC:HSF1)) |
| pmid:25784053 | act(p(HGNC:ERN1), ma(kin)) increases p(HGNC:ERN1, pmod(Ph)) |
| pmid:25784053 | act(p(HGNC:ERN1), ma(GO:"ribonuclease activity")) increases p(HGNC:XBP1) |
| pmid:25784053 | p(HGNC:ERN1, pmod(Ph)) increases act(p(HGNC:ERN1), ma(GO:"ribonuclease activity")) |
| pmid:25784053 | act(p(HGNC:XBP1), ma(tscript)) increases bp(GO:"response to misfolded protein") |
| pmid:25784053 | bp(MESH:"Endoplasmic Reticulum Stress") increases tloc(p(HGNC:ATF6), fromLoc(MESH:"Endoplasmic Reticulum"), toLoc(MESH:"Golgi Apparatus")) |
| pmid:25784053 | bp(MESH:"Endoplasmic Reticulum Stress") increases act(p(HGNC:EIF2AK3), ma(kin)) |
| pmid:25784053 | p(HGNC:ATF6) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:25784053 | p(HGNC:ATF6) negativeCorrelation path(MESH:"Huntington Disease") |
| pmid:25784053 | p(HGNC:PRSS1) decreases p(HGNC:ATF6) |
| pmid:25784053 | p(HGNC:PRSS1) increases p(HBP:"N-terminal fragment of ATF6") |
| pmid:25784053 | p(HGNC:PRSS2) decreases p(HGNC:ATF6) |
| pmid:25784053 | p(HGNC:PRSS2) increases p(HBP:"N-terminal fragment of ATF6") |
| pmid:25784053 | tloc(p(HBP:"N-terminal fragment of ATF6"), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) increases act(p(HBP:"N-terminal fragment of ATF6"), ma(tscript)) |
| pmid:25784053 | act(p(HBP:"N-terminal fragment of ATF6"), ma(tscript)) increases bp(GO:"response to misfolded protein") |
| pmid:25784053 | act(p(HGNC:EIF2AK3), ma(kin)) increases p(HGNC:EIF2S1, pmod(Ph)) |
| pmid:25784053 | p(HGNC:EIF2S1, pmod(Ph)) increases act(p(HGNC:EIF2S1), ma(tscript)) |
| pmid:23702978 | p(HGNC:EIF2S1, pmod(Ph)) decreases bp(GO:translation) |
| pmid:25784053 | act(p(HGNC:EIF2S1), ma(tscript)) increases p(HGNC:ATF4) |
| pmid:25784053 | p(HGNC:ATF4) increases p(HGNC:DDIT3) |
| pmid:25784053 | p(HGNC:DDIT3) increases bp(GO:"apoptotic process") |
| pmid:23702978 | p(HGNC:DDIT3) regulates a(CHEBI:"calcium(2+)") |
| pmid:23702978 | p(HGNC:DDIT3) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:25784053 | p(HGNC:ATXN1, var("?")) causesNoChange p(FPLX:HSPA) |
| pmid:25784053 | p(HGNC:HSPA1A) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pmid:22817713 | p(HGNC:HSPA1A) decreases a(HBP:"Tau aggregates") |
| pmid:22817713 | p(HGNC:HSPA1A) increases deg(a(HBP:"Tau aggregates")) |
| pmid:25784053 | p(HGNC:HSPA1B) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pmid:25784053 | p(MGI:Atg5) decreases bp(HP:Neurodegeneration) |
| pmid:25784053 | p(MGI:Atg7) decreases bp(HP:Neurodegeneration) |
| pmid:24027553 | p(MGI:Atg7) decreases path(HBP:Neurodegeneration) |
| pmid:24027553 | p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph)) |
| pmid:24027553 | p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) |
| pmid:24027553 | p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:24027553 | p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph, Thr, 231)) |
| pmid:25784053 | p(HGNC:RAB1A) increases bp(GO:"autophagosome assembly") |
| pmid:29238289 | p(HGNC:RAB1A) association p(HGNC:MAPT) |
| pmid:25784053 | p(HGNC:SOD1, var("p.Gly576Arg")) decreases a(CHEBI:"N-retinylidene-N-retinylethanolamine") |
| pmid:25784053 | p(HGNC:SOD1, var("p.Gly576Arg")) decreases p(HGNC:MAP1LC3A) |
| pmid:25784053 | p(HGNC:SOD1, var("p.Gly576Arg")) decreases p(HGNC:SQSTM1) |
| pmid:25784053 | p(HGNC:SOD1, var("p.Gly576Arg")) increases bp(GO:autophagy) |
| pmid:24027553 | p(HGNC:MAP1LC3A) positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pmid:30116051 | p(HGNC:SQSTM1) association path(MESH:"Frontotemporal Dementia") |
| pmid:30116051 | p(HGNC:SQSTM1) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:25784053 | a(CHEBI:chloroquine) decreases bp(GO:autophagy) |
| pmid:25784053 | a(CHEBI:chloroquine) increases a(CHEBI:"N-retinylidene-N-retinylethanolamine") |
| pmid:25784053 | a(CHEBI:chloroquine) increases p(HGNC:MAP1LC3A) |
| pmid:25784053 | a(CHEBI:chloroquine) increases p(HGNC:SQSTM1) |
| pmid:24027553 | a(CHEBI:chloroquine) increases p(HGNC:MAPT) |
| pmid:24027553 | a(CHEBI:chloroquine) decreases deg(p(HGNC:MAPT)) |
| pmid:25784053 | a(CHEBI:radicicol) decreases act(p(FPLX:HSP90)) |
| pmid:21882945 | a(CHEBI:radicicol) directlyDecreases act(p(FPLX:HSP90)) |
| pmid:21882945 | a(CHEBI:radicicol) directlyIncreases complex(a(CHEBI:radicicol), p(INTERPRO:"Heat shock protein Hsp90, N-terminal")) |
| pmid:25784053 | a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) |
| pmid:30116051 | a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) |
| pmid:21882945 | a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) |
| pmid:21882945 | a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) |
| pmid:30116051 | a(CHEBI:geldanamycin) decreases p(HGNC:MAPT, pmod(HBP:HBP00007)) |
| pmid:30116051 | a(CHEBI:geldanamycin) decreases a(HBP:HBP00016) |
| pmid:24027553 | a(CHEBI:geldanamycin) increases act(p(HGNCGENEFAMILY:Proteasome)) |
| pmid:21882945 | a(CHEBI:geldanamycin) decreases complex(p(FPLX:HSP90), p(HGNC:PTGES3)) |
| pmid:25784053 | a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) |
| pmid:30116051 | a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) |
| pmid:21882945 | a(CHEBI:tanespimycin) directlyDecreases act(p(FPLX:HSP90)) |
| pmid:21882945 | a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) |
| pmid:29311797 | a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pmid:30116051 | a(CHEBI:tanespimycin) decreases a(CHEBI:"amyloid-beta") |
| pmid:30116051 | a(CHEBI:tanespimycin) increases bp(GO:memory) |
| pmid:30116051 | a(CHEBI:tanespimycin) decreases p(HGNC:MAPT) |
| pmid:30116051 | a(CHEBI:tanespimycin) decreases a(HBP:HBP00016) |
| pmid:21882945 | a(CHEBI:tanespimycin) directlyIncreases complex(a(CHEBI:tanespimycin), p(INTERPRO:"Heat shock protein Hsp90, N-terminal")) |
| pmid:21882945 | a(CHEBI:tanespimycin) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| pmid:21882945 | a(CHEBI:tanespimycin) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) |
| pmid:29311797 | a(CHEBI:tanespimycin) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:21367866 | a(CHEBI:tanespimycin) decreases act(p(SFAM:"HSP90 Family")) |
| pmid:25784053 | a(PUBCHEM:377503130) increases act(p(HGNC:HSF1)) |
| pmid:25784053 | a(PUBCHEM:377503130) decreases act(p(FPLX:"CCT_complex")) |
| pmid:30116051 | p(FPLX:mTORC1) increases bp(GO:macroautophagy) |
| pmid:30116051 | p(FPLX:mTORC1) decreases bp(GO:macroautophagy) |
| pmid:30116051 | p(FPLX:mTORC1) decreases bp(GO:mitophagy) |
| pmid:30116051 | p(FPLX:mTORC1) increases p(HGNC:ULK1, pmod(Ph, Ser, 757)) |
| pmid:30116051 | p(FPLX:mTORC1) decreases tloc(p(HGNC:TFEB), fromLoc(MESH:Cytoplasm), toLoc(MESH:"Cell Nucleus")) |
| pmid:30116051 | act(p(FPLX:mTORC1)) increases act(p(HGNC:TFEB)) |
| pmid:30116051 | act(p(FPLX:mTORC1)) increases act(p(HGNC:NFE2L2)) |
| pmid:30116051 | p(FPLX:mTORC1) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:30116051 | p(FPLX:mTORC1) decreases bp(GO:"proteasome assembly") |
| pmid:23528736 | p(FPLX:mTORC1) decreases bp(GO:autophagy) |
| pmid:23528736 | act(p(FPLX:mTORC1), ma(kin)) increases p(HGNC:ULK1, pmod(Ph)) |
| pmid:23528736 | act(p(FPLX:mTORC1)) increases p(HGNC:MAPT) |
| pmid:30108137 | p(FPLX:mTORC1) increases p(MGI:Tfeb, pmod(Ph)) |
| pmid:25784053 | a(PUBCHEM:10521421) decreases act(p(FPLX:AKT)) |
| pmid:25784053 | a(PUBCHEM:10521421) increases bp(GO:autophagy) |
| pmid:25784053 | a(CHEBI:fluphenazine) increases bp(GO:autophagy) |
| pmid:25784053 | a(CHEBI:fluphenazine) decreases p(HGNC:TARDBP) |
| pmid:25784053 | a(CHEBI:methotrimeprazine) increases bp(GO:autophagy) |
| pmid:25784053 | a(CHEBI:methotrimeprazine) decreases p(HGNC:TARDBP) |
| pmid:29334120 | act(p(HGNC:TARDBP)) increases p(HBP:"4R tau") |
| pmid:25784053 | a(PUBCHEM:799645) increases bp(GO:autophagy) |
| pmid:25784053 | a(PUBCHEM:799645) decreases p(HGNC:SNCA, var("p.Ala53Thr")) |
| pmid:25784053 | a(PUBCHEM:799645) decreases a(HBP:"huntingtin aggregates") |
| pmid:25784053 | a(PUBCHEM:877863) increases bp(GO:autophagy) |
| pmid:25784053 | a(PUBCHEM:877863) decreases p(HGNC:SNCA, var("p.Ala53Thr")) |
| pmid:25784053 | a(PUBCHEM:877863) decreases a(HBP:"huntingtin aggregates") |
| pmid:25784053 | a(PUBCHEM:1560402) increases bp(GO:autophagy) |
| pmid:25784053 | a(PUBCHEM:1560402) decreases p(HGNC:SNCA, var("p.Ala53Thr")) |
| pmid:25784053 | a(PUBCHEM:1560402) decreases a(HBP:"huntingtin aggregates") |
| pmid:25784053 | composite(a(CHEBI:sirolimus), a(PUBCHEM:799645)) decreases p(HGNC:SNCA, var("p.Ala53Thr")) |
| pmid:25784053 | composite(a(CHEBI:sirolimus), a(PUBCHEM:877863)) decreases p(HGNC:SNCA, var("p.Ala53Thr")) |
| pmid:25784053 | composite(a(CHEBI:sirolimus), a(PUBCHEM:1560402)) decreases p(HGNC:SNCA, var("p.Ala53Thr")) |
| pmid:25784053 | a(PUBCHEM:675434) decreases p(HGNC:MAPT) |
| pmid:23528736 | a(PUBCHEM:675434) increases deg(p(HGNC:MAPT)) |
| pmid:25784053 | a(PUBCHEM:675434) decreases p(HGNC:TARDBP) |
| pmid:25784053 | a(PUBCHEM:675434) decreases p(HGNC:ATXN3) |
| pmid:25784053 | a(PUBCHEM:675434) decreases act(p(HGNC:USP14)) |
| pmid:23528736 | a(PUBCHEM:675434) decreases act(p(HGNC:USP14)) |
| pmid:25784053 | a(PUBCHEM:675434) causesNoChange p(FPLX:Proteasome) |
| pmid:23528736 | a(PUBCHEM:675434) increases act(p(FPLX:Proteasome)) |
| pmid:25036637 | p(INTERPRO:"Heat shock protein 70 family") directlyIncreases complex(p(HGNC:BAG2), p(HGNC:HSPA8), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:25036637 | p(INTERPRO:"Heat shock protein 70 family") directlyIncreases complex(p(HGNC:HSF1), p(HGNC:TP53), p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:21882945 | p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") |
| pmid:21882945 | p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:"proteasomal protein catabolic process") |
| pmid:21882945 | p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:autophagy) |
| pmid:21882945 | p(INTERPRO:"Heat shock protein 70 family") increases act(p(HGNC:STUB1)) |
| pmid:21882945 | p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:"protein catabolic process") |
| pmid:21882945 | p(INTERPRO:"Heat shock protein 70 family") increases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:21882945 | act(p(INTERPRO:"Heat shock protein 70 family")) increases deg(p(HGNC:MAPT)) |
| pmid:21882945 | act(p(INTERPRO:"Heat shock protein 70 family")) increases p(HGNC:MAPT) |
| pmid:18500754 | p(INTERPRO:"Heat shock protein 70 family") association complex(GO:microtubule) |
| pmid:25036637 | p(INTERPRO:"Heat shock protein Hsp90 family") association p(INTERPRO:"NudC family") |
| pmid:29844403 | act(p(INTERPRO:"Heat shock protein Hsp90 family")) positiveCorrelation act(p(HGNC:HDAC6)) |
| pmid:25036637 | p(HGNC:DNAJC7) increases complex(p(HGNC:DNAJC7), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(HGNC:DNAJB6) increases complex(p(HGNC:DNAJB6), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(HGNC:HSPBP1) increases complex(p(HGNC:HSPBP1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(HGNC:EDRF1) increases complex(p(HGNC:EDRF1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(HGNC:RNF41) increases complex(p(HGNC:RNF41), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:AHSA1), p(HGNC:CDC37)) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:AURKB), p(HGNC:CDC37)) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CDK11A)) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CDK1)) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:IKBKG)) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CDK4)) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:FER)) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CHUK)) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:RAF1)) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:ABL2), p(HGNC:CDC37)) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(p(HGNC:ARAF), p(HGNC:CDC37)) |
| pmid:25036637 | p(HGNC:CDC37) association p(HGNC:FKBP5) |
| pmid:25036637 | p(HGNC:CDC37) directlyIncreases complex(a(MESH:"Protein Kinases"), p(HGNC:CDC37)) |
| pmid:21882945 | p(HGNC:CDC37) regulates act(p(FPLX:HSP90)) |
| pmid:21882945 | p(HGNC:CDC37) increases complex(a(MESH:"Protein Kinases"), p(FPLX:HSP90)) |
| pmid:29311797 | p(HGNC:CDC37) increases p(HGNC:MAPT) |
| pmid:21367866 | p(HGNC:CDC37) decreases deg(p(HGNC:MAPT)) |
| pmid:21367866 | p(HGNC:CDC37) positiveCorrelation act(p(SFAM:"HSP90 Family")) |
| pmid:21367866 | p(HGNC:CDC37) isA complex(p(HGNC:CDC37), p(SFAM:"HSP90 Family")) |
| pmid:21367866 | p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:21367866 | p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:21367866 | p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:21367866 | p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:21367866 | p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:21367866 | p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:21367866 | p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356)) |
| pmid:21367866 | p(HGNC:CDC37) positiveCorrelation act(p(HGNC:CDK5)) |
| pmid:21367866 | p(HGNC:CDC37) causesNoChange p(HGNC:GSK3B) |
| pmid:21367866 | p(HGNC:CDC37) causesNoChange p(HGNC:MARK2) |
| pmid:25036637 | p(HGNC:CDC37L1) directlyIncreases complex(p(HGNC:CDC37L1), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(HGNC:CDC37L1) directlyIncreases complex(p(HGNC:CDC37L1), p(HGNC:STIP1)) |
| pmid:21882945 | p(HGNC:AHSA1) regulates act(p(FPLX:HSP90)) |
| pmid:29311797 | p(HGNC:AHSA1) increases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pmid:21882945 | p(HGNC:AHSA1) increases rxn(reactants(a(CHEBI:ATP)), products(a(CHEBI:"phosphate(3-)"), a(CHEBI:ADP))) |
| pmid:21882945 | p(HGNC:AHSA1) increases complex(a(CHEBI:polypeptide), p(HGNC:STUB1)) |
| pmid:29311797 | p(HGNC:AHSA1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29311797 | p(HGNC:AHSA1) increases a(HBP:"Tau oligomers") |
| pmid:29311797 | p(HGNC:AHSA1) increases bp(GO:"neuron apoptotic process") |
| pmid:29311797 | p(HGNC:AHSA1) increases a(HBP:"Tau aggregates") |
| pmid:29311797 | p(HGNC:AHSA1) association path(MESH:"Cystic Fibrosis") |
| pmid:25036637 | p(INTERPRO:"Cdc37, N-terminal domain") increases act(p(HGNC:CDC37)) |
| pmid:25036637 | complex(p(HGNC:CDC37L1), p(INTERPRO:"Cdc37, N-terminal domain")) regulates complex(p(HGNC:ARAF), p(HGNC:CDC37L1), p(INTERPRO:"Cdc37, N-terminal domain")) |
| pmid:25036637 | p(INTERPRO:"Tetratricopeptide repeat") increases complex(a(MESH:"Tacrolimus Binding Proteins"), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:AURKB), p(HGNC:FKBP5)) |
| pmid:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CDK11A), p(HGNC:FKBP5)) |
| pmid:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CDK1), p(HGNC:FKBP5)) |
| pmid:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:IKBKG)) |
| pmid:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CDK4), p(HGNC:FKBP5)) |
| pmid:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FER), p(HGNC:FKBP5)) |
| pmid:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CHUK), p(HGNC:FKBP5)) |
| pmid:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:RAF1)) |
| pmid:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:ABL2), p(HGNC:FKBP5)) |
| pmid:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:ARAF), p(HGNC:FKBP5)) |
| pmid:25036637 | p(HGNC:FKBP5) association p(HGNC:CDC37) |
| pmid:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:AGO1), p(HGNC:FKBP5)) |
| pmid:25036637 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:AGO2), p(HGNC:FKBP5)) |
| pmid:25036637 | p(HGNC:FKBP5) association p(HGNC:EGLN1) |
| pmid:25036637 | p(HGNC:FKBP5) association p(HGNC:PDCD2) |
| pmid:25036637 | p(HGNC:FKBP5) association p(HGNC:ANKMY2) |
| pmid:25036637 | p(HGNC:FKBP5) increases complex(p(HGNC:FKBP5), p(HGNC:MCM4)) |
| pmid:25036637 | p(HGNC:FKBP5) increases complex(p(HGNC:FKBP5), p(HGNC:MCMBP)) |
| pmid:25036637 | p(HGNC:FKBP5) regulates bp(GO:"cellular response to DNA damage stimulus") |
| pmid:21882945 | p(HGNC:FKBP5) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:21882945 | p(HGNC:FKBP5) increases complex(p(FPLX:HSP90), p(HGNC:MAPT)) |
| pmid:21882945 | p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:MAPT)) |
| pmid:20071522 | p(HGNC:FKBP5) isA complex(p(HGNC:FKBP5), p(HGNC:MAPT)) |
| pmid:21882945 | p(HGNC:FKBP5) positiveCorrelation bp(GO:aging) |
| pmid:21882945 | p(HGNC:FKBP5) increases p(HGNC:MAPT) |
| pmid:20071522 | p(HGNC:FKBP5) increases p(HGNC:MAPT) |
| pmid:21882945 | p(HGNC:FKBP5) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29311797 | p(HGNC:FKBP5) isA a(MESH:Immunophilins) |
| pmid:20071522 | p(HGNC:FKBP5) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:20071522 | p(HGNC:FKBP5) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:20071522 | p(HGNC:FKBP5) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:20071522 | p(HGNC:FKBP5) negativeCorrelation complex(p(HGNC:AHSA1), p(HGNC:MAPT)) |
| pmid:20071522 | p(HGNC:FKBP5) positiveCorrelation complex(p(HGNC:MAPT), p(SFAM:"HSP90 Family")) |
| pmid:20071522 | p(HGNC:FKBP5) decreases complex(p(HGNC:MAPT), p(HGNC:PTGES3)) |
| pmid:20071522 | p(HGNC:FKBP5) increases bp(GO:"microtubule polymerization") |
| pmid:10391244 | act(p(HGNC:CDK1)) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:10391244 | p(HGNC:CDK1) positiveCorrelation complex(GO:"neurofibrillary tangle") |
| pmid:29686391 | p(HGNC:CDK4) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:25036637 | p(HGNC:AGO1) directlyIncreases complex(p(HGNC:AGO1), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(HGNC:AGO1) directlyIncreases complex(p(HGNC:AGO2), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(HGNC:AGO1) positiveCorrelation bp(GO:"ribonucleoprotein complex biogenesis") |
| pmid:25036637 | p(HGNC:AGO2) positiveCorrelation bp(GO:"ribonucleoprotein complex biogenesis") |
| pmid:25036637 | bp(GO:"ribonucleoprotein complex biogenesis") positiveCorrelation p(HGNC:AGO1) |
| pmid:25036637 | bp(GO:"ribonucleoprotein complex biogenesis") positiveCorrelation p(HGNC:AGO2) |
| pmid:25036637 | p(HGNC:EGLN1) association p(HGNC:FKBP5) |
| pmid:25036637 | p(HGNC:EGLN1) association p(INTERPRO:"Zinc finger, MYND-type") |
| pmid:25036637 | p(INTERPRO:"Zinc finger, MYND-type") association p(HGNC:EGLN1) |
| pmid:25036637 | p(INTERPRO:"Zinc finger, MYND-type") increases complex(p(HGNC:EGLN1), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(INTERPRO:"Zinc finger, MYND-type") association p(HGNC:PDCD2) |
| pmid:25036637 | p(INTERPRO:"Zinc finger, MYND-type") increases complex(p(HGNC:PDCD2), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(INTERPRO:"Zinc finger, MYND-type") association p(HGNC:ANKMY2) |
| pmid:25036637 | p(INTERPRO:"Zinc finger, MYND-type") increases complex(p(HGNC:ANKMY2), p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | p(HGNC:PDCD2) association p(HGNC:FKBP5) |
| pmid:25036637 | p(HGNC:PDCD2) association p(INTERPRO:"Zinc finger, MYND-type") |
| pmid:25036637 | p(HGNC:ANKMY2) association p(HGNC:FKBP5) |
| pmid:25036637 | p(HGNC:ANKMY2) association p(INTERPRO:"Zinc finger, MYND-type") |
| pmid:25036637 | p(HGNC:MCM4) increases bp(GO:"DNA replication initiation") |
| pmid:25036637 | p(HGNC:MCM4) increases bp(GO:"replication fork progression beyond termination site") |
| pmid:25036637 | p(HGNC:MCMBP) increases bp(GO:"DNA replication initiation") |
| pmid:25036637 | p(HGNC:MCMBP) increases bp(GO:"replication fork progression beyond termination site") |
| pmid:25036637 | p(HGNC:MCMBP) increases complex(p(HGNC:MCM2), p(HGNC:MCMBP)) |
| pmid:25036637 | p(HGNC:MCMBP) increases complex(p(HGNC:MCM3), p(HGNC:MCMBP)) |
| pmid:25036637 | p(HGNC:MCMBP) increases complex(p(HGNC:MCM4), p(HGNC:MCMBP)) |
| pmid:25036637 | p(HGNC:MCMBP) increases complex(p(HGNC:MCM5), p(HGNC:MCMBP)) |
| pmid:25036637 | p(HGNC:MCMBP) increases complex(p(HGNC:MCM6), p(HGNC:MCMBP)) |
| pmid:25036637 | p(HGNC:MCMBP) increases complex(p(HGNC:MCM7), p(HGNC:MCMBP)) |
| pmid:25036637 | p(HGNC:MCMBP) increases complex(p(HGNC:FKBP5), p(HGNC:MCMBP)) |
| pmid:23702978 | bp(GO:"cellular response to DNA damage stimulus") increases complex(GO:ripoptosome) |
| pmid:25036637 | p(HGNC:FKBP8) increases complex(p(HGNC:FKBP8), p(HGNC:PDCL)) |
| pmid:25036637 | p(HGNC:FKBP8) association bp(GO:"G protein-coupled receptor signaling pathway") |
| pmid:29311797 | p(HGNC:FKBP8) isA a(MESH:Immunophilins) |
| pmid:25036637 | p(HGNC:PDCL) association p(INTERPRO:"G-protein, gamma subunit") |
| pmid:25036637 | p(HGNC:PDCL) isA a(MESH:"Molecular Chaperones") |
| pmid:25036637 | bp(GO:"G protein-coupled receptor signaling pathway") association p(HGNC:FKBP8) |
| pmid:25036637 | p(INTERPRO:"G-protein, gamma subunit") association p(HGNC:PDCL) |
| pmid:25036637 | p(HGNC:FKBP6) increases complex(p(HGNC:FKBP6), p(HGNC:OSBP)) |
| pmid:29311797 | p(HGNC:FKBP6) isA a(MESH:Immunophilins) |
| pmid:25036637 | a(HBP:"OSW-1") decreases complex(p(HGNC:FKBP6), p(HGNC:OSBP)) |
| pmid:25036637 | p(INTERPRO:"BAG domain") regulates act(p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:25036637 | p(HGNC:BAG1) increases complex(p(HGNC:BAG1), p(HGNC:LTN1)) |
| pmid:25036637 | p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMA5)) |
| pmid:25036637 | p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMC4)) |
| pmid:25036637 | p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMD2)) |
| pmid:21882945 | p(HGNC:BAG1) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21882945 | p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:MAPT)) |
| pmid:21882945 | p(HGNC:BAG1) decreases deg(p(HGNC:MAPT)) |
| pmid:17954934 | p(HGNC:BAG1) positiveCorrelation p(HGNC:MAPT) |
| pmid:17954934 | p(HGNC:BAG1) decreases deg(p(HGNC:MAPT)) |
| pmid:17954934 | p(HGNC:BAG1) isA complex(p(HGNC:BAG1), p(HGNC:MAPT), p(HGNC:STUB1)) |
| pmid:17954934 | p(HGNC:BAG1) negativeCorrelation act(complex(GO:"proteasome complex")) |
| pmid:17954934 | p(HGNC:BAG1) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:25036637 | p(HGNC:LTN1) association bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") |
| pmid:25036637 | bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") association p(HGNC:LTN1) |
| pmid:21882945 | bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") association a(MESH:"Molecular Chaperones") |
| pmid:25036637 | p(HGNC:BAG3) increases complex(p(HGNC:BAG3), p(HGNC:HSPB8)) |
| pmid:25036637 | p(HGNC:BAG3) increases complex(p(HGNC:BAG3), p(HGNC:HSPB1)) |
| pmid:25036637 | p(HGNC:BAG3) directlyIncreases complex(p(HGNC:BAG3), p(HGNC:HSPB1)) |
| pmid:25036637 | p(HGNC:BAG3) increases complex(p(HGNC:BAG3), p(HGNC:HSF1)) |
| pmid:25036637 | p(HGNC:BAG3) directlyIncreases complex(p(HGNC:BAG3), p(HGNC:DCP1B)) |
| pmid:29626319 | p(HGNC:BAG3) increases deg(p(HGNC:MAPT)) |
| pmid:21882945 | p(HGNC:HSPB1) increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") |
| pmid:21882945 | p(HGNC:HSPB1) increases bp(GO:"proteasomal protein catabolic process") |
| pmid:21882945 | p(HGNC:HSPB1) increases bp(GO:autophagy) |
| pmid:21882945 | p(HGNC:HSPB1) directlyIncreases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) |
| pmid:21882945 | p(HGNC:HSPB1) directlyIncreases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) |
| pmid:14963027 | p(HGNC:HSPB1) increases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) |
| pmid:21882945 | p(HGNC:HSPB1) increases p(HGNC:MAPT) |
| pmid:21882945 | p(HGNC:HSPB1) decreases p(HGNC:MAPT) |
| pmid:14963027 | p(HGNC:HSPB1) causesNoChange p(HGNC:MAPT) |
| pmid:21882945 | p(HGNC:HSPB1) directlyIncreases complex(a(MESH:"Neurofibrillary Tangles"), p(HGNC:HSPB1)) |
| pmid:21882945 | p(HGNC:HSPB1) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pmid:14963027 | p(HGNC:HSPB1) association p(HGNC:MAPT, pmod(Ph)) |
| pmid:14963027 | p(HGNC:HSPB1) decreases act(p(HGNC:MAPT, pmod(Ph))) |
| pmid:14963027 | p(HGNC:HSPB1) negativeCorrelation bp(GO:"neuron apoptotic process") |
| pmid:25036637 | p(HGNC:BAG5) increases complex(p(HGNC:BAG5), p(HGNC:MAD1L1)) |
| pmid:25036637 | p(HGNC:BAG5) increases complex(p(HGNC:BAG5), p(HGNC:MAD2L1)) |
| pmid:25036637 | p(HGNC:BAG4) increases complex(p(HGNC:BAG4), p(HGNC:DCP1A)) |
| pmid:25036637 | p(HGNC:BAG4) increases complex(p(HGNC:BAG4), p(HGNC:EDC3)) |
| pmid:25036637 | p(HGNC:BAG4) increases complex(p(HGNC:BAG4), p(HGNC:DDX6)) |
| pmid:25036637 | p(HGNC:BAG4) negativeCorrelation complex(GO:"P-body") |
| pmid:25036637 | p(HGNC:BAG4) directlyIncreases complex(p(HGNC:BAG4), p(HGNC:HSPB1)) |
| pmid:25036637 | p(HGNC:BAG4) directlyIncreases complex(p(HGNC:BAG4), p(HGNC:DCP1B)) |
| pmid:25036637 | p(HGNC:DCP1A) association bp(GO:"cellular protein catabolic process") |
| pmid:25036637 | p(HGNC:DCP1A) association bp(GO:"gene silencing") |
| pmid:25036637 | p(HGNC:EDC3) association bp(GO:"cellular protein catabolic process") |
| pmid:25036637 | p(HGNC:EDC3) association bp(GO:"gene silencing") |
| pmid:25036637 | p(HGNC:DDX6) association bp(GO:"cellular protein catabolic process") |
| pmid:25036637 | p(HGNC:DDX6) association bp(GO:"gene silencing") |
| pmid:25036637 | bp(GO:"cellular protein catabolic process") association p(HGNC:DCP1A) |
| pmid:25036637 | bp(GO:"cellular protein catabolic process") association p(HGNC:EDC3) |
| pmid:25036637 | bp(GO:"cellular protein catabolic process") association p(HGNC:DDX6) |
| pmid:27671637 | bp(GO:"cellular protein catabolic process") negativeCorrelation composite(a(HP:"Argyrophilic inclusion bodies"), p(MGI:Mapt)) |
| pmid:25036637 | complex(GO:"P-body") negativeCorrelation p(HGNC:BAG4) |
| pmid:25036637 | complex(GO:"P-body") association p(HGNC:BAG4, var("p.Asp424Ala")) |
| pmid:25036637 | complex(GO:"P-body") negativeCorrelation p(HGNC:BAG4, var("p.Asp424Ala")) |
| pmid:25036637 | p(HGNC:BAG4, var("p.Asp424Ala")) decreases complex(p(HGNC:BAG4, var("p.Asp424Ala")), p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:25036637 | p(HGNC:BAG4, var("p.Asp424Ala")) association complex(GO:"P-body") |
| pmid:25036637 | p(HGNC:BAG4, var("p.Asp424Ala")) negativeCorrelation complex(GO:"P-body") |
| pmid:25036637 | a(PUBCHEM:23624255) decreases act(p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:RPAP3)) |
| pmid:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:SUGT1)) |
| pmid:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:SUGT1)) |
| pmid:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP4), p(HGNC:HSP90AB1)) |
| pmid:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP4), p(HGNC:HSP90AB1)) |
| pmid:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:BAG3), p(HGNC:HSPA8)) |
| pmid:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:BAG1), p(HGNC:HSPA8)) |
| pmid:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:BAG4), p(HGNC:HSPA8)) |
| pmid:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:BAG5), p(HGNC:HSPA8)) |
| pmid:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP5), p(HGNC:HSP90AB1)) |
| pmid:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:HSPA8), p(HGNC:SUGT1)) |
| pmid:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP4), p(HGNC:HSPA8)) |
| pmid:25036637 | a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP5), p(HGNC:HSPA8)) |
| pmid:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:HSP90AB1), p(HGNC:SIRT6)) |
| pmid:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:AR), p(HGNC:HSP90AB1)) |
| pmid:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:HSPA8), p(HGNC:SIRT6)) |
| pmid:25036637 | a(PUBCHEM:23624255) increases complex(p(HGNC:AR), p(HGNC:HSPA8)) |
| pmid:25036637 | p(HGNC:RPAP3) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:RPAP3)) |
| pmid:25036637 | p(HGNC:RPAP3) directlyIncreases complex(p(HGNC:RPAP3), p(HGNC:RPAP3)) |
| pmid:25036637 | p(HGNC:RPAP3) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:RPAP3)) |
| pmid:25036637 | p(HGNC:SUGT1) directlyIncreases complex(p(HGNC:SUGT1), p(INTERPRO:"Leucine-rich repeat domain superfamily")) |
| pmid:25036637 | p(HGNC:SUGT1) directlyIncreases complex(p(HGNC:SUGT1), p(INTERPRO:"Leucine-rich repeat")) |
| pmid:29311797 | p(HGNC:FKBP4) isA a(MESH:Immunophilins) |
| pmid:29311797 | p(HGNC:FKBP4) increases a(HBP:"Tau aggregates") |
| pmid:26903089 | act(p(HGNC:FKBP4)) association p(HBP:"VQIVYK motif") |
| pmid:21882945 | p(HGNC:BAG2) directlyIncreases complex(p(HGNC:BAG2), p(HGNC:MAPT), p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:21882945 | p(HGNC:BAG2) association deg(p(HGNC:MAPT, pmod(Ph))) |
| pmid:21882945 | p(HGNC:BAG2) decreases act(p(HGNC:STUB1)) |
| pmid:21882945 | p(HGNC:BAG2) decreases bp(GO:"protein ubiquitination") |
| pmid:21882945 | p(HGNC:BAG2) decreases complex(p(HGNC:STUB1), p(HGNC:UBA2)) |
| pmid:25036637 | p(HGNC:PSMC1) directlyIncreases complex(p(HGNC:PSMC1), p(HGNC:PSMC2)) |
| pmid:25036637 | p(HGNC:PSMC1) directlyIncreases complex(p(HGNC:PSMC1), p(HGNC:PSMD2)) |
| pmid:25036637 | p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5)) |
| pmid:25036637 | p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5)) |
| pmid:25036637 | p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5)) |
| pmid:25036637 | p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN2)) |
| pmid:25036637 | p(INTERPRO:"BAG domain superfamily") directlyIncreases complex(p(HGNC:HSPA6), p(INTERPRO:"BAG domain superfamily")) |
| pmid:25036637 | p(INTERPRO:"BAG domain superfamily") directlyIncreases complex(p(HGNC:HSPA8), p(INTERPRO:"BAG domain superfamily")) |
| pmid:25036637 | p(HGNC:UNC45A) directlyIncreases complex(p(HGNC:HSP90AB1), p(HGNC:UNC45A)) |
| pmid:25036637 | p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMD2)) |
| pmid:25036637 | p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG2), p(HGNC:PSMD2)) |
| pmid:25036637 | p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG3), p(HGNC:PSMD2)) |
| pmid:25036637 | p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG5), p(HGNC:PSMD2)) |
| pmid:25036637 | p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:PSMD2), p(HGNC:STUB1)) |
| pmid:25036637 | p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:PSMD2), p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:21882945 | complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) increases deg(p(HGNC:MAPT)) |
| pmid:21882945 | complex(p(FPLX:HSP90), p(HGNC:STUB1)) association p(HGNC:AKT1) |
| pmid:25036637 | p(HGNC:VBP1) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:VBP1)) |
| pmid:25036637 | p(HGNC:VBP1) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:VBP1)) |
| pmid:25036637 | p(HGNC:VBP1) directlyIncreases complex(p(HGNC:PFDN5), p(HGNC:VBP1)) |
| pmid:25036637 | p(HGNC:UXT) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:UXT)) |
| pmid:25036637 | p(HGNC:UXT) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:UXT)) |
| pmid:25036637 | p(HGNC:UXT) directlyIncreases complex(p(HGNC:PFDN5), p(HGNC:UXT)) |
| pmid:25036637 | p(HGNC:PDRG1) directlyIncreases complex(p(HGNC:PDRG1), p(HGNC:PFDN2), p(HGNC:PFDN5)) |
| pmid:25036637 | p(HGNC:PDRG1) directlyIncreases complex(p(HGNC:PDRG1), p(HGNC:PFDN2)) |
| pmid:25036637 | p(HGNC:PDRG1) directlyIncreases complex(p(HGNC:PDRG1), p(HGNC:PFDN5)) |
| pmid:25036637 | p(HGNC:POLR3A) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:POLR3A)) |
| pmid:25036637 | p(HGNC:POLR3A) directlyIncreases complex(p(HGNC:POLR3A), p(HGNC:RPAP3)) |
| pmid:25036637 | p(HGNC:POLR3A) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:POLR3A)) |
| pmid:25036637 | p(HGNC:URI1) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:URI1)) |
| pmid:25036637 | p(HGNC:URI1) directlyIncreases complex(p(HGNC:RPAP3), p(HGNC:URI1)) |
| pmid:25036637 | p(HGNC:URI1) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:URI1)) |
| pmid:25036637 | p(INTERPRO:"Leucine-rich repeat domain superfamily") directlyIncreases complex(p(HGNC:SUGT1), p(INTERPRO:"Leucine-rich repeat domain superfamily")) |
| pmid:25036637 | a(MESH:"Argonaute Proteins") directlyIncreases complex(a(MESH:"Argonaute Proteins"), p(HGNC:PPP5C)) |
| pmid:25036637 | a(MESH:"Argonaute Proteins") directlyIncreases complex(a(MESH:"Argonaute Proteins"), p(HGNC:PTGES3)) |
| pmid:21882945 | p(HGNC:PPP5C) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29311797 | act(p(HGNC:PPP5C)) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:21882945 | p(HGNC:PTGES3) increases complex(a(MESH:"Protein Kinases"), p(FPLX:HSP90)) |
| pmid:29311797 | p(HGNC:PTGES3) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pmid:29311797 | p(HGNC:PTGES3) decreases path(MESH:"Protein Aggregation, Pathological") |
| pmid:29311797 | p(HGNC:PTGES3) increases p(HGNC:MAPT) |
| pmid:29311797 | p(HGNC:PTGES3) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29311797 | p(HGNC:PTGES3) decreases bp(GO:"cell death in response to oxidative stress") |
| pmid:25036637 | p(INTERPRO:"NudC family") association p(INTERPRO:"Heat shock protein Hsp90 family") |
| pmid:25036637 | p(HGNC:NUDC) directlyIncreases complex(p(HGNC:NUDC), p(INTERPRO:"WD40-repeat-containing domain superfamily")) |
| pmid:25036637 | p(HGNC:NUDC) directlyIncreases complex(p(HGNC:NUDC), p(INTERPRO:"WD40-repeat-containing domain")) |
| pmid:25036637 | p(HGNC:NUDC) directlyIncreases complex(p(HGNC:NUDC), p(INTERPRO:"WD40-repeat-containing domain")) |
| pmid:25036637 | p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:KLHL13), p(HGNC:NUDCD3)) |
| pmid:25036637 | p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:KLHL1), p(HGNC:NUDCD3)) |
| pmid:25036637 | p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:ENC1), p(HGNC:NUDCD3)) |
| pmid:25036637 | p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:NUDCD3), p(INTERPRO:"Kelch-type beta propeller")) |
| pmid:25036637 | p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:NUDCD3), p(INTERPRO:"Kelch-type beta propeller")) |
| pmid:25036637 | p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:FBXO24), p(HGNC:NUDCD2)) |
| pmid:25036637 | p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:NUDCD2), p(HGNC:SNX31)) |
| pmid:25036637 | p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:NUDCD2), p(INTERPRO:"Regulator of chromosome condensation, RCC1")) |
| pmid:25036637 | p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:NUDCD2), p(INTERPRO:"Regulator of chromosome condensation, RCC1")) |
| pmid:25036637 | p(HGNC:CFAP100) directlyIncreases complex(p(HGNC:ARAF), p(HGNC:CDC37)) |
| pmid:25036637 | p(HGNC:NUDCD1) directlyIncreases complex(p(HGNC:NUDCD1), p(INTERPRO:"DEAD/DEAH box helicase domain")) |
| pmid:25036637 | p(HGNC:NUDCD1) directlyIncreases complex(a(GO:"COPI-coated vesicle"), p(HGNC:NUDCD1)) |
| pmid:25036637 | a(GO:"COPI-coated vesicle") regulates bp(GO:"retrograde transport, vesicle recycling within Golgi") |
| pmid:28803412 | p(HGNC:SNCA, var("p.Glu46Lys")) increases path(MESH:"Parkinson Disease") |
| pmid:28803412 | p(HGNC:SNCA, var("p.His50Gln")) increases path(MESH:"Parkinson Disease") |
| pmid:28803412 | p(HGNC:SNCA, var("p.Gly51Asp")) increases path(MESH:"Parkinson Disease") |
| pmid:28803412 | p(HGNC:SNCA, var("p.Ala53Glu")) increases path(MESH:"Parkinson Disease") |
| pmid:28803412 | a(HBP:HBP00016) increases path(MESH:"Parkinson Disease") |
| pmid:27075649 | a(HBP:HBP00016) positiveCorrelation path(MESH:"Parkinson Disease") |
| pmid:27075649 | a(HBP:HBP00016) positiveCorrelation path(MESH:"Multiple System Atrophy") |
| pmid:27075649 | a(HBP:HBP00016) positiveCorrelation path(MESH:"Lewy Body Disease") |
| pmid:30116051 | a(HBP:HBP00016) decreases complex(GO:"proteasome complex") |
| pmid:28803412 | a(HBP:HBP00093) increases path(MESH:"Parkinson Disease") |
| pmid:28803412 | a(HBP:HBP00093) biomarkerFor path(MESH:"Parkinson Disease") |
| pmid:28803412 | a(HBP:HBP00093) positiveCorrelation path(MESH:"Parkinson Disease") |
| pmid:28803412 | a(HBP:HBP00093) increases a(HBP:HBP00092) |
| pmid:27075649 | a(HBP:HBP00093) negativeCorrelation a(HBP:HBP00092) |
| pmid:28803412 | a(HBP:HBP00093) increases bp(GO:"apoptotic process") |
| pmid:28803412 | a(HBP:HBP00093) increases bp(GO:"apoptotic process") |
| pmid:27075649 | a(HBP:HBP00093) increases bp(GO:"apoptotic process") |
| pmid:28803412 | a(HBP:HBP00093) decreases a(MESH:Mitochondria) |
| pmid:28803412 | a(HBP:HBP00093) increases bp(HBP:HBP00037) |
| pmid:28803412 | a(HBP:HBP00093) increases bp(MESH:"Endoplasmic Reticulum Stress") |
| pmid:28803412 | a(HBP:HBP00093) decreases act(complex(GO:"proteasome complex")) |
| pmid:28803412 | a(HBP:HBP00093) increases bp(GO:"microglial cell activation") |
| pmid:28803412 | a(HBP:HBP00093) increases bp(GO:"inflammatory response") |
| pmid:28803412 | a(HBP:HBP00093) increases act(p(HGNC:TLR2)) |
| pmid:28803412 | a(HBP:HBP00093) increases a(CHEBI:"reactive oxygen species") |
| pmid:28803412 | a(HBP:HBP00093) decreases a(MESH:"Cell Membrane") |
| pmid:28803412 | a(HBP:HBP00093) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular space"), toLoc(GO:"intracellular part")) |
| pmid:27075649 | a(HBP:HBP00093) increases a(CHEBI:"calcium(2+)") |
| pmid:28803412 | a(HBP:HBP00093) decreases bp(GO:"synaptic vesicle transport") |
| pmid:28803412 | a(HBP:HBP00093) decreases bp(GO:"axonal transport") |
| pmid:28803412 | a(HBP:HBP00093) decreases complex(a(GO:microtubule), a(MESH:Kinesin)) |
| pmid:28803412 | a(HBP:HBP00093) decreases a(MESH:"Golgi Apparatus") |
| pmid:28803412 | a(HBP:HBP00092) causesNoChange bp(GO:"apoptotic process") |
| pmid:27075649 | a(HBP:HBP00092) increases bp(GO:"apoptotic process") |
| pmid:28803412 | a(HBP:HBP00092) increases bp(GO:"inflammatory response") |
| pmid:28803412 | a(HBP:HBP00092) increases bp(GO:"microglial cell activation") |
| pmid:27075649 | a(HBP:HBP00092) increases a(CHEBI:"calcium(2+)") |
| pmid:27075649 | a(HBP:HBP00092) negativeCorrelation a(HBP:HBP00093) |
| pmid:27075649 | a(HBP:HBP00092) increases a(HBP:HBP00016) |
| pmid:28803412 | p(HGNC:LRRK2, var("p.Gly2019Ser")) increases path(MESH:"Neurodegenerative Diseases") |
| pmid:24113872 | p(HGNC:LRRK2) positiveCorrelation path(MESH:"Parkinson Disease") |
| pmid:24113872 | act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 149)) |
| pmid:24113872 | act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 153)) |
| pmid:24113872 | act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 205)) |
| pmid:24113872 | act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(HBP:"Tau epitope, AT8") |
| pmid:24113872 | act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(HBP:"Tau aggregates") |
| pmid:30126037 | act(a(MESH:Mitochondria)) association bp(GO:"cellular respiration") |
| pmid:28803412 | a(CHEBI:salubrinal) decreases bp(MESH:"Endoplasmic Reticulum Stress") |
| pmid:28803412 | a(CHEBI:salubrinal) decreases a(HBP:HBP00093) |
| pmid:28803412 | p(HGNC:HDAC6) decreases a(HBP:HBP00093) |
| pmid:29311797 | p(HGNC:HDAC6) increases act(p(HGNC:AIP)) |
| pmid:29311797 | p(HGNC:HDAC6) association a(HBP:"Tau aggregates") |
| pmid:26751493 | p(HGNC:HDAC6) association p(HBP:"microtubule-binding region") |
| pmid:26751493 | p(HGNC:HDAC6) association a(HBP:"microtubule-binding region") |
| pmid:25031639 | act(p(HGNC:HDAC6)) positiveCorrelation a(HBP:"Tau epitope, 12E8") |
| pmid:24844691 | act(p(HGNC:HDAC6)) negativeCorrelation p(FPLX:Tubulin, pmod(Ac)) |
| pmid:25546293 | act(p(HGNC:HDAC6)) negativeCorrelation p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) |
| pmid:23487739 | act(p(HGNC:HDAC6)) negativeCorrelation a(GO:microtubule) |
| pmid:23487739 | act(p(HGNC:HDAC6)) decreases p(INTERPRO:"Tubulin/FtsZ, GTPase domain", pmod(Ac)) |
| pmid:28760828 | p(HGNC:HDAC6) positiveCorrelation p(HGNC:MAPT) |
| pmid:28760828 | p(HGNC:HDAC6) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 324)) |
| pmid:29844403 | act(p(HGNC:HDAC6)) positiveCorrelation act(p(INTERPRO:"Heat shock protein Hsp90 family")) |
| pmid:23702978 | a(CHEBI:"reactive oxygen species") increases act(p(HGNC:TRPM2)) |
| pmid:23702978 | a(CHEBI:"reactive oxygen species") increases bp(GO:"apoptosome assembly") |
| pmid:21339331 | a(MESH:"Cell Membrane") association p(HGNC:ANXA2) |
| pmid:21339331 | a(MESH:"Cell Membrane") isA complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) |
| pmid:28803412 | p(HGNC:TFEB) decreases a(HBP:HBP00093) |
| pmid:30116051 | p(HGNC:TFEB) increases bp(GO:macroautophagy) |
| pmid:30116051 | tloc(p(HGNC:TFEB), fromLoc(MESH:Cytoplasm), toLoc(MESH:"Cell Nucleus")) increases bp(GO:macroautophagy) |
| pmid:30116051 | p(HGNC:TFEB) decreases a(HBP:HBP00018) |
| pmid:30108137 | p(HGNC:TFEB) decreases act(a(MESH:Lysosomes)) |
| pmid:29626319 | p(HGNC:TFEB) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | p(HGNC:TFEB) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:TFEB) regulates deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:TFEB) increases act(a(GO:lysosome)) |
| pmid:29626319 | p(HGNC:TFEB) increases act(a(GO:lysosome)) |
| pmid:29626319 | p(HGNC:TFEB) decreases path(MESH:"Plaque, Amyloid") |
| pmid:29626319 | p(HGNC:TFEB) regulates deg(a(MESH:"Neurofibrillary Tangles")) |
| pmid:29626319 | p(HGNC:TFEB) regulates deg(p(HGNC:MAPT, pmod(Ph))) |
| pmid:29626319 | p(HGNC:TFEB) increases bp(GO:autophagy) |
| pmid:28803412 | complex(a(HBP:HBP00093), p(HGNC:VAMP1)) decreases bp(GO:"SNARE complex assembly") |
| pmid:28803412 | p(HGNC:USP19) increases sec(p(HGNC:SNCA)) |
| pmid:28803412 | a(CHEBI:curcumin) decreases a(HBP:HBP00092) |
| pmid:28803412 | a(CHEBI:curcumin) decreases a(HBP:HBP00016) |
| pmid:30116051 | a(CHEBI:curcumin) decreases a(HBP:HBP00016) |
| pmid:28803412 | a(CHEBI:curcumin) decreases a(HBP:HBP00018) |
| pmid:30116051 | a(CHEBI:curcumin) increases bp(GO:macroautophagy) |
| pmid:30116051 | a(CHEBI:curcumin) decreases act(p(FPLX:mTORC1)) |
| pmid:30116051 | a(CHEBI:curcumin) increases deg(p(HGNC:SNCA, var("p.Ala53Thr"))) |
| pmid:30116051 | a(CHEBI:curcumin) decreases a(HBP:HBP00022) |
| pmid:30116051 | a(CHEBI:curcumin) decreases a(HBP:HBP00009) |
| pmid:28803412 | a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00016) |
| pmid:28803412 | a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00018) |
| pmid:28803412 | a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00017) |
| pmid:29626319 | a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29626319 | a(CHEBI:"(-)-epigallocatechin 3-gallate") increases p(HGNC:CALCOCO2) |
| pmid:29626319 | a(CHEBI:"(-)-epigallocatechin 3-gallate") increases p(HGNC:SQSTM1) |
| pmid:28775333 | a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases p(MGI:Dyrk1a) |
| pmid:28775333 | a(CHEBI:"(-)-epigallocatechin 3-gallate") negativeCorrelation p(HBP:"3R tau") |
| pmid:28775333 | a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases path(MESH:Anxiety) |
| pmid:28775333 | a(CHEBI:"(-)-epigallocatechin 3-gallate") positiveCorrelation bp(GO:memory) |
| pmid:28803412 | a(HBP:HBP00094) decreases a(HBP:HBP00016) |
| pmid:28803412 | a(HBP:HBP00094) decreases bp(GO:"apoptotic process") |
| pmid:27075649 | path(MESH:"Multiple System Atrophy") positiveCorrelation a(HBP:HBP00016) |
| pmid:27075649 | a(HBP:HBP00095) increases bp(GO:"neuron death") |
| pmid:27075649 | a(HBP:HBP00095) decreases bp(GO:"ion homeostasis") |
| pmid:27075649 | a(HBP:HBP00095) increases a(HBP:HBP00016) |
| pmid:27075649 | a(CHEBI:glutaraldehyde) increases a(HBP:HBP00093) |
| pmid:29807032 | act(p(NCBIGENE:140621)) association bp(MESH:"Heat-Shock Response") |
| pmid:29807032 | p(NCBIGENE:492507) decreases act(p(NCBIGENE:140621)) |
| pmid:29807032 | path(MESH:"Stress Disorders, Traumatic") increases p(MESH:"corticotropin releasing factor-binding protein") |
| pmid:23211705 | p(MGI:Crh) decreases a(MESH:Estradiol) |
| pmid:23211705 | p(MGI:Crh) regulates p(HGNC:CGB3) |
| pmid:23211705 | p(MGI:Crh) decreases p(HGNC:CGB3) |
| pmid:23211705 | p(MGI:Crh) causesNoChange a(MESH:Progesterone) |
| pmid:23211705 | p(MGI:Crh) decreases a(MESH:Progesterone) |
| pmid:23211705 | p(MGI:Crh) decreases a(MESH:Progesterone) |
| pmid:25125464 | p(MGI:Crh) increases p(HBP:"Tau epitope, AT8") |
| pmid:25125464 | p(MGI:Crh) increases a(HBP:"Tau epitope, PHF1") |
| pmid:25125464 | p(MGI:Crh) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 262)) |
| pmid:25125464 | p(MGI:Crh) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 422)) |
| pmid:8940412 | act(p(RGD:Crh)) positiveCorrelation bp(GO:"inflammatory response") |
| pmid:8940412 | act(p(RGD:Crh)) regulates sec(p(RGD:Pomc)) |
| pmid:8940412 | act(p(RGD:Crh)) directlyIncreases act(p(RGD:Crhr1)) |
| pmid:8940412 | a(CHEBI:antalarmin) directlyDecreases act(p(RGD:Crh)) |
| pmid:8940412 | a(CHEBI:antalarmin) directlyDecreases act(p(RGD:Crhr1)) |
| pmid:8940412 | a(CHEBI:antalarmin) negativeCorrelation bp(GO:"inflammatory response") |
| pmid:8940412 | a(CHEBI:antalarmin) decreases sec(p(RGD:Pomc)) |
| pmid:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) |
| pmid:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) |
| pmid:22072628 | act(p(HGNC:CDK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) |
| pmid:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:8282104 | p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:22072628 | p(HGNC:CDK2) increases a(HBP:"Tau epitope, AT180") |
| pmid:22072628 | act(p(HGNC:CDK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 212)) |
| pmid:22072628 | act(p(HGNC:CDK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 217)) |
| pmid:8282104 | p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:8282104 | p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:8282104 | p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:8282104 | p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) |
| pmid:8282104 | p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:8282104 | p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:8282104 | p(FPLX:GSK3) association a(GO:microtubule) |
| pmid:8282104 | p(FPLX:GSK3) association a(HBP:HBP00006) |
| pmid:8282104 | p(FPLX:GSK3) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(Ph)))) |
| pmid:8282104 | p(FPLX:GSK3) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26458742 | p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:20071522 | p(HGNC:MAPT, pmod(Ph, Ser, 199)) isA p(RGD:Mapt, pmod(Ph)) |
| pmid:20071522 | p(HGNC:MAPT, pmod(Ph, Ser, 199)) association complex(p(HGNC:FKBP5), p(HGNC:MAPT)) |
| pmid:20071522 | p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation p(HGNC:FKBP5) |
| pmid:21367866 | p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation p(HGNC:CDC37) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation p(FPLX:PKA) |
| pmid:25331948 | p(HGNC:MAPT, pmod(Ph, Ser, 199)) partOf p(HBP:"Tau epitope, AT8") |
| pmid:19459590 | p(HGNC:MAPT, pmod(Ph, Ser, 199)) partOf p(HBP:"Tau epitope, AT8") |
| pmid:28784767 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf p(HBP:"Tau epitope, AT8") |
| pmid:18239272 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf p(HBP:"Tau epitope, AT8") |
| pmid:22817713 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) association a(HBP:"Tau aggregates") |
| pmid:22817713 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) association a(HBP:"Tau oligomers") |
| pmid:22486774 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf a(HBP:"Tau oligomers") |
| pmid:14612456 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) isA p(HGNC:MAPT, pmod(Ph)) |
| pmid:20071522 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) isA p(RGD:Mapt, pmod(Ph)) |
| pmid:20071522 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) association complex(p(HGNC:FKBP5), p(HGNC:MAPT)) |
| pmid:20071522 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:FKBP5) |
| pmid:21367866 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:CDC37) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(FPLX:PKA) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 202))) |
| pmid:25331948 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) equivalentTo a(HBP:"Tau epitope, CP13") |
| pmid:26118667 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) negativeCorrelation m(MIRBASE:"rno-mir-195") |
| pmid:19459590 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) equivalentTo p(HBP:"Tau epitope, CP13") |
| pmid:22833681 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) |
| pmid:24406748 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) |
| pmid:23294633 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pmid:22002427 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Glu391*")) |
| pmid:22002427 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:22253473 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf a(GO:"neurofibrillary tangle") |
| pmid:16464864 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation a(CHEBI:"okadaic acid") |
| pmid:16464864 | p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, pmod(Sumo, Lys, 340)) |
| pmid:22072628 | p(HGNC:MAPT, pmod(Ph, Ser, 235)) partOf p(HBP:"proline-rich region 2", pmod(Ph)) |
| pmid:26996941 | p(HGNC:MAPT, pmod(Ph, Ser, 235)) association act(p(HGNC:PIN1)) |
| pmid:28420982 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26458742 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28420982 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:14612456 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) isA p(HGNC:MAPT, pmod(Ph)) |
| pmid:20071522 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) isA p(RGD:Mapt, pmod(Ph)) |
| pmid:20071522 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) association complex(p(HGNC:FKBP5), p(HGNC:MAPT)) |
| pmid:20071522 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(HGNC:FKBP5) |
| pmid:21367866 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(HGNC:CDC37) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(FPLX:PKA) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 396))) |
| pmid:22156579 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation a(HBP:"Tau epitope, PHF1") |
| pmid:23948915 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) negativeCorrelation bp(GO:"apoptotic process") |
| pmid:28176663 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation a(CHEBI:"D-ribose") |
| pmid:22833681 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) |
| pmid:29844403 | p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation act(p(HGNC:GSK3B)) |
| pmid:24760868 | p(HGNC:MAPT, pmod(Ph, Ser, 404)) increases p(HGNC:MAPT, loc(MESH:"Dendritic Spines")) |
| pmid:26458742 | p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:14612456 | p(HGNC:MAPT, pmod(Ph, Ser, 404)) isA p(HGNC:MAPT, pmod(Ph)) |
| pmid:21367866 | p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation p(HGNC:CDC37) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Ser, 404)) negativeCorrelation p(FPLX:PKA) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Ser, 404)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 404))) |
| pmid:11943212 | p(HGNC:MAPT, pmod(Ph, Ser, 404)) partOf p(HBP:"Tau epitope, AD2") |
| pmid:22156579 | p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation a(HBP:"Tau epitope, PHF1") |
| pmid:8282104 | a(HBP:HBP00172) directlyIncreases p(HBP:HBP00053, pmod(Ph)) |
| pmid:8282104 | complex(a(HBP:HBP00172), p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:8282104 | a(HBP:HBP00006) association p(HGNC:CDK5) |
| pmid:8282104 | a(HBP:HBP00006) association p(HGNC:PRKACA) |
| pmid:8282104 | a(HBP:HBP00006) association p(FPLX:ERK) |
| pmid:8282104 | a(HBP:HBP00006) association p(FPLX:GSK3) |
| pmid:30116051 | a(HBP:HBP00006) decreases act(complex(GO:"proteasome complex")) |
| pmid:30116051 | a(HBP:HBP00006) decreases bp(GO:"chaperone-mediated autophagy") |
| pmid:26458742 | a(HBP:HBP00006) increases tloc(p(HGNC:MAPT), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Neurons)) |
| pmid:26458742 | a(HBP:HBP00006) causesNoChange bp(GO:"cell death") |
| pmid:27594586 | g(DBSNP:rs63751011) increases p(HGNC:MAP2) |
| pmid:27594586 | g(DBSNP:rs63751011) causesNoChange a(GO:"symmetric, GABA-ergic, inhibitory synapse") |
| pmid:27594586 | g(DBSNP:rs63751011) causesNoChange p(HGNC:SLC17A7) |
| pmid:27594586 | g(DBSNP:rs63751011) causesNoChange p(HGNC:MAPT) |
| pmid:27594586 | g(DBSNP:rs63751011) causesNoChange p(HGNC:DLGAP4) |
| pmid:27594586 | g(DBSNP:rs63751011) causesNoChange bp(MESH:"Membrane Potentials") |
| pmid:27594586 | g(DBSNP:rs63751011) causesNoChange bp(GO:"neuron differentiation") |
| pmid:27594586 | g(DBSNP:rs63751011) increases act(p(HGNC:MMP9)) |
| pmid:27594586 | g(DBSNP:rs63751011) increases sec(p(HGNC:MMP9)) |
| pmid:27594586 | g(DBSNP:rs63751011) increases r(HGNC:MMP9) |
| pmid:27594586 | g(DBSNP:rs63751011) increases r(HGNC:MMP9) |
| pmid:27594586 | g(DBSNP:rs63751011) increases r(HGNC:MMP2) |
| pmid:27594586 | g(DBSNP:rs63751011) increases r(HGNC:MMP2) |
| pmid:27594586 | g(DBSNP:rs63751011) increases bp(GO:"neuron death") |
| pmid:27594586 | g(DBSNP:rs63751011) increases a(HBP:HBP00045) |
| pmid:27594586 | g(DBSNP:rs63751011) decreases a(HBP:HBP00044) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases p(HGNC:MAP2) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange a(GO:"symmetric, GABA-ergic, inhibitory synapse") |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:SLC17A7) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:MAPT) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:DLGAP4) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange bp(MESH:"Membrane Potentials") |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange bp(GO:"neuron differentiation") |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP2)) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP2)) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP2)) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP9) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP9) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP2) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP2) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases bp(GO:"neuron death") |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases p(FPLX:ERK, pmod(Ph)) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) increases a(HBP:HBP00045) |
| pmid:27594586 | p(HGNC:MAPT, var("p.Ala152Thr")) decreases a(HBP:HBP00044) |
| pmid:29024336 | p(HGNC:MAPT, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) |
| pmid:27594586 | path(MESH:"Neurodevelopmental Disorders") association act(p(HGNC:MMP9)) |
| pmid:27594586 | act(p(HGNC:MMP2)) increases bp(GO:"neuron death") |
| pmid:27594586 | p(HGNC:MMP2) increases bp(GO:"neuron death") |
| pmid:29626319 | act(p(HGNC:MMP2)) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:27594586 | a(CHEBI:staurosporine) increases bp(GO:"apoptotic process") |
| pmid:8726973 | a(CHEBI:staurosporine) decreases act(p(HGNC:CDK5)) |
| pmid:23666762 | a(CHEBI:staurosporine) decreases act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin)) |
| pmid:23001711 | a(CHEBI:staurosporine) decreases act(p(HGNC:MARK2), ma(kin)) |
| pmid:23001711 | a(CHEBI:staurosporine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:27594586 | a(CHEBI:rotenone) increases bp(HBP:HBP00037) |
| pmid:27594586 | composite(a(CHEBI:sirolimus), p(HGNC:MAPT, var("p.Ala152Thr"))) increases bp(GO:"neuron death") |
| pmid:27594586 | composite(a(CHEBI:rotenone), p(HGNC:MAPT, var("p.Ala152Thr"))) causesNoChange bp(GO:"neuron death") |
| pmid:27594586 | composite(a(CHEBI:staurosporine), p(HGNC:MAPT, var("p.Ala152Thr"))) causesNoChange bp(GO:"neuron death") |
| pmid:27594586 | p(FPLX:ERK, pmod(Ph)) positiveCorrelation act(p(HGNC:MMP9)) |
| pmid:27594586 | p(FPLX:ERK, pmod(Ph)) positiveCorrelation sec(p(HGNC:MMP9)) |
| pmid:24686445 | p(FPLX:ERK, pmod(Ph)) increases act(p(FPLX:ERK)) |
| pmid:27594586 | a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases p(FPLX:ERK, pmod(Ph)) |
| pmid:27594586 | a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases sec(p(HGNC:MMP9)) |
| pmid:27594586 | a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases act(p(HGNC:MMP9)) |
| pmid:27594586 | a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") causesNoChange act(p(HGNC:MMP2)) |
| pmid:27594586 | a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") causesNoChange p(HGNC:MMP2) |
| pmid:27594586 | p(HBP:HBP00045, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) |
| pmid:27594586 | p(HBP:HBP00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) |
| pmid:27594586 | p(HBP:HBP00045, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) |
| pmid:27594586 | p(HBP:HBP00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) |
| pmid:27594586 | p(HBP:HBP00045, var("p.Ala152Thr")) increases r(HGNC:MMP9) |
| pmid:27594586 | p(HBP:HBP00045, var("p.Ala152Thr")) increases p(FPLX:ERK, pmod(Ph)) |
| pmid:27594586 | p(HBP:HBP00045, var("p.Ala152Thr")) increases bp(GO:"ERK1 and ERK2 cascade") |
| pmid:27594586 | p(HBP:HBP00045, var("p.Ala152Thr")) increases sec(p(HGNC:MMP2)) |
| pmid:27594586 | p(HBP:HBP00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP2)) |
| pmid:27594586 | p(HBP:HBP00044, var("p.Ala152Thr")) causesNoChange sec(p(HGNC:MMP9)) |
| pmid:27594586 | p(HBP:HBP00044, var("p.Ala152Thr")) causesNoChange act(p(HGNC:MMP9)) |
| pmid:27594586 | p(HBP:HBP00044, var("p.Ala152Thr")) causesNoChange p(FPLX:ERK, pmod(Ph)) |
| pmid:30116051 | p(FPLX:AMPK) increases bp(GO:macroautophagy) |
| pmid:30116051 | p(FPLX:AMPK) decreases bp(GO:mitophagy) |
| pmid:30116051 | p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(Ph, Ser, 317)) |
| pmid:30116051 | p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(Ph, Ser, 777)) |
| pmid:30116051 | p(FPLX:AMPK) increases p(FPLX:mTORC1, pmod(Ph)) |
| pmid:30116051 | p(FPLX:AMPK) increases a(CHEBI:"NAD(+)") |
| pmid:30116051 | act(p(FPLX:AMPK)) increases bp(GO:autophagy) |
| pmid:30116051 | act(p(FPLX:AMPK)) increases bp(GO:autophagy) |
| pmid:23528736 | p(FPLX:AMPK) increases bp(GO:autophagy) |
| pmid:30116051 | act(p(FPLX:AMPK)) increases act(p(HGNC:SIRT1)) |
| pmid:23528736 | p(FPLX:AMPK) decreases act(p(FPLX:mTORC1)) |
| pmid:23528736 | p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(Ph)) |
| pmid:30116051 | bp(GO:mitophagy) negativeCorrelation g(HGNC:PSEN1, var("?")) |
| pmid:30116051 | p(HGNC:ULK1) increases bp(GO:macroautophagy) |
| pmid:30116051 | act(p(HGNC:ULK1)) increases bp(GO:"autophagosome assembly") |
| pmid:30116051 | act(p(HGNC:ULK1)) increases p(HGNC:AMBRA1, pmod(Ph)) |
| pmid:30116051 | act(p(HGNC:ULK1)) increases p(HGNC:BECN1, pmod(Ph)) |
| pmid:23528736 | p(HGNC:ULK1) increases bp(GO:autophagy) |
| pmid:30116051 | a(CHEBI:"NAD(+)") increases act(p(HGNC:SIRT1)) |
| pmid:30116051 | a(CHEBI:"NAD(+)") increases act(p(HGNC:SIRT1)) |
| pmid:30116051 | p(HGNC:SIRT1) increases bp(GO:macroautophagy) |
| pmid:30116051 | act(p(HGNC:SIRT1)) decreases act(p(FPLX:mTORC1)) |
| pmid:30116051 | act(p(HGNC:SIRT1)) increases act(p(HGNC:FOXO1)) |
| pmid:30116051 | act(p(HGNC:SIRT1)) increases act(p(HGNC:FOXO3)) |
| pmid:30116051 | act(p(HGNC:SIRT1)) increases act(p(HGNC:ATG5)) |
| pmid:30116051 | act(p(HGNC:SIRT1)) increases act(p(HGNC:ATG7)) |
| pmid:30116051 | act(p(HGNC:SIRT1)) increases act(p(HGNC:MAP1LC3A)) |
| pmid:20869593 | act(p(HGNC:SIRT1)) negativeCorrelation p(HGNC:MAPT, pmod(Ac)) |
| pmid:20869593 | act(p(HGNC:SIRT1)) negativeCorrelation p(HBP:"Tau epitope, AT8") |
| pmid:29540553 | act(p(HGNC:SIRT1)) negativeCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 174)) |
| pmid:29540553 | act(p(HGNC:SIRT1)) negativeCorrelation a(HBP:"Pathological Tau Spreading") |
| pmid:29540553 | act(p(HGNC:SIRT1)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29540553 | p(HGNC:SIRT1) positiveCorrelation bp(GO:learning) |
| pmid:29540553 | p(HGNC:SIRT1) positiveCorrelation bp(GO:memory) |
| pmid:29226865 | act(p(HGNC:SIRT1)) directlyDecreases p(HGNC:SRSF2, pmod(Ac, Lys, 52)) |
| pmid:30116051 | p(HGNC:ULK1, pmod(Ph, Ser, 317)) increases act(p(HGNC:ULK1)) |
| pmid:30116051 | p(HGNC:ULK1, pmod(Ph, Ser, 777)) increases act(p(HGNC:ULK1)) |
| pmid:30116051 | p(FPLX:mTORC1, pmod(Ph)) decreases act(p(FPLX:mTORC1)) |
| pmid:30116051 | p(HGNC:ULK1, pmod(Ph, Ser, 757)) decreases act(p(HGNC:ULK1)) |
| pmid:30116051 | p(HGNC:FOXO1) increases bp(GO:macroautophagy) |
| pmid:30116051 | p(HGNC:FOXO3) increases bp(GO:macroautophagy) |
| pmid:30116051 | p(HGNC:ZKSCAN3) decreases bp(GO:macroautophagy) |
| pmid:30116051 | p(HGNC:AMBRA1, pmod(Ph)) increases act(p(HGNC:AMBRA1)) |
| pmid:30116051 | act(p(HGNC:AMBRA1)) increases bp(GO:"autophagosome assembly") |
| pmid:30116051 | p(HGNC:BECN1, pmod(Ph)) increases act(p(HGNC:BECN1)) |
| pmid:30116051 | act(p(HGNC:BECN1)) increases bp(GO:"autophagosome assembly") |
| pmid:27260836 | p(HGNC:BECN1) positiveCorrelation p(HGNC:PICALM) |
| pmid:30116051 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) |
| pmid:30116051 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) |
| pmid:30116051 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) |
| pmid:30116051 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) |
| pmid:30116051 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:TARDBP)) |
| pmid:30116051 | bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:APP)) |
| pmid:30116051 | bp(GO:"chaperone-mediated autophagy") causesNoChange deg(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pmid:30116051 | bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(HGNC:HTT)) |
| pmid:30116051 | bp(GO:"chaperone-mediated autophagy") increases act(p(HGNC:MEF2D)) |
| pmid:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt)) |
| pmid:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt)) |
| pmid:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt)) |
| pmid:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(a(HBP:HBP00053)) |
| pmid:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(a(HBP:HBP00053)) |
| pmid:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) |
| pmid:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) |
| pmid:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) |
| pmid:29024336 | bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Pro301Leu"))) |
| pmid:29024336 | bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(MGI:Mapt, var("p.Pro301Leu"))) |
| pmid:29024336 | bp(GO:"chaperone-mediated autophagy") decreases path(MESH:"Proteostasis Deficiencies") |
| pmid:29311797 | bp(GO:"chaperone-mediated autophagy") association p(FPLX:HSP90) |
| pmid:29311797 | bp(GO:"chaperone-mediated autophagy") association p(HGNC:STIP1) |
| pmid:30116051 | p(HGNC:LGMN) increases p(HGNC:MAPT, frag("?")) |
| pmid:30116051 | p(HGNC:MAPT, frag("?")) decreases bp(GO:"chaperone-mediated autophagy") |
| pmid:29626319 | p(HGNC:MAPT, frag("?")) increases bp(HBP:neurotoxicity) |
| pmid:30116051 | act(complex(GO:"lysosomal proton-transporting V-type ATPase complex")) negativeCorrelation g(HGNC:PSEN1, var("?")) |
| pmid:29024336 | a(GO:lysosome) increases deg(a(HBP:HBP00053)) |
| pmid:29590627 | a(GO:lysosome) association p(HGNC:MAPT, var("p.Pro301Ser")) |
| pmid:29590627 | a(GO:lysosome) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | a(GO:lysosome) association a(HBP:"Tau aggregates") |
| pmid:29590627 | a(GO:lysosome) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:24561250 | a(GO:lysosome) decreases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:30116051 | p(HGNC:MAPT, pmod(HBP:HBP00007)) decreases deg(p(HGNC:MAPT)) |
| pmid:30116051 | p(HGNC:PINK1, var("?")) association path(MESH:"Parkinson Disease") |
| pmid:30116051 | p(HGNC:PINK1, var("?")) decreases bp(GO:mitophagy) |
| pmid:30116051 | p(HGNC:LRRK2, var("?")) association path(MESH:"Parkinson Disease") |
| pmid:30116051 | p(HGNC:LRRK2, var("?")) decreases bp(GO:autophagy) |
| pmid:30116051 | p(HGNC:LRRK2, var("?")) decreases act(p(HGNC:BECN1)) |
| pmid:30116051 | p(HGNC:LRRK2, var("?")) association bp(HBP:HBP00073) |
| pmid:30116051 | p(HGNC:LRRK2, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| pmid:30116051 | p(HGNC:GBA, var("?")) increases path(MESH:"Gaucher Disease") |
| pmid:30116051 | p(HGNC:GBA, var("?")) decreases bp(GO:autophagy) |
| pmid:30116051 | p(HGNC:GBA, var("?")) increases a(HBP:HBP00016) |
| pmid:30116051 | p(HGNC:GBA, var("?")) increases path(MESH:"Parkinson Disease") |
| pmid:30116051 | path(MESH:"Frontotemporal Dementia") association p(HGNC:SQSTM1) |
| pmid:30116051 | path(MESH:"Frontotemporal Dementia") association p(HGNC:C9orf72) |
| pmid:30116051 | path(MESH:"Frontotemporal Dementia") increases act(p(HGNC:ABL1)) |
| pmid:29024336 | path(MESH:"Frontotemporal Dementia") increases path(MESH:"Proteostasis Deficiencies") |
| pmid:24027553 | path(MESH:"Frontotemporal Dementia") association p(HGNC:MAPT, var("p.P301L")) |
| pmid:24027553 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:NPEPPS) |
| pmid:30108137 | path(MESH:"Frontotemporal Dementia") increases r(HGNC:TFEB) |
| pmid:30108137 | path(MESH:"Frontotemporal Dementia") increases r(HGNC:LAMP1) |
| pmid:30108137 | path(MESH:"Frontotemporal Dementia") increases p(HGNC:TFEB) |
| pmid:30108137 | path(MESH:"Frontotemporal Dementia") increases p(HGNC:CTSD) |
| pmid:28420982 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT) |
| pmid:28420982 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:28420982 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:26751493 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pmid:26751493 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Val337Met")) |
| pmid:26751493 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Gly272Val")) |
| pmid:26751493 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Arg406Trp")) |
| pmid:26751493 | path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:PSEN1, var("p.Gly183Val")) |
| pmid:8391280 | path(MESH:"Frontotemporal Dementia") positiveCorrelation g(DBSNP:rs63750424) |
| pmid:30116051 | p(HGNC:C9orf72) association path(MESH:"Frontotemporal Dementia") |
| pmid:30116051 | p(HGNC:CHMP2B) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:30116051 | p(HGNC:TBK1) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:30116051 | p(HGNC:OPTN) association path(MESH:"Amyotrophic Lateral Sclerosis") |
| pmid:30116051 | p(HGNC:OPTN, var("?")) decreases bp(GO:"cargo loading into vesicle") |
| pmid:30116051 | p(HGNC:TBK1, var("?")) decreases bp(GO:"cargo loading into vesicle") |
| pmid:30116051 | p(HGNC:C9orf72, var("?")) decreases bp(GO:autophagy) |
| pmid:30116051 | a(CHEBI:"methylene blue") decreases a(HBP:HBP00009) |
| pmid:30116051 | a(CHEBI:"methylene blue") increases bp(GO:autophagy) |
| pmid:30116051 | a(CHEBI:"methylene blue") increases bp(GO:autophagy) |
| pmid:23528736 | a(CHEBI:"methylene blue") increases bp(GO:autophagy) |
| pmid:29626319 | a(CHEBI:"methylene blue") increases bp(GO:autophagy) |
| pmid:30116051 | a(CHEBI:"methylene blue") increases act(p(FPLX:AMPK)) |
| pmid:30116051 | a(CHEBI:"methylene blue") increases p(HGNC:BECN1) |
| pmid:30116051 | a(CHEBI:"methylene blue") increases p(HGNC:MAP1LC3A) |
| pmid:30116051 | a(CHEBI:"methylene blue") increases p(HGNC:DCTN4) |
| pmid:30116051 | a(CHEBI:"methylene blue") decreases act(p(HGNC:MAPT)) |
| pmid:23528736 | a(CHEBI:"methylene blue") decreases p(HGNC:MAPT) |
| pmid:24027553 | a(CHEBI:"methylene blue") increases bp(MESH:Autophagy) |
| pmid:23528736 | a(CHEBI:"methylene blue") decreases a(HBP:"Tau aggregates") |
| pmid:23528736 | a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:21882945 | a(CHEBI:"methylene blue") decreases act(p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:26751493 | a(CHEBI:"methylene blue") decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(CHEBI:"methylene blue") decreases act(p(HGNC:CASP1)) |
| pmid:26751493 | a(CHEBI:"methylene blue") decreases act(p(HGNC:CASP3)) |
| pmid:23666762 | a(CHEBI:"methylene blue") decreases act(p(HGNC:MARK4), ma(kin)) |
| pmid:23666762 | a(CHEBI:"methylene blue") increases deg(p(HGNC:MARK4)) |
| pmid:28287136 | a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(Ac)) |
| pmid:30116051 | a(CHEBI:clonidine) increases bp(GO:autophagy) |
| pmid:30116051 | a(CHEBI:clonidine) increases deg(p(HGNC:HTT)) |
| pmid:30116051 | a(CHEBI:Rilmenidine) increases bp(GO:autophagy) |
| pmid:30116051 | a(CHEBI:Rilmenidine) increases deg(p(HGNC:HTT)) |
| pmid:30116051 | p(HGNC:CAPN1) decreases bp(GO:autophagy) |
| pmid:30116051 | p(HGNC:CAPN1) decreases deg(p(HGNC:HTT, var("?"))) |
| pmid:30116051 | p(HGNC:CAPN2) decreases bp(GO:autophagy) |
| pmid:30116051 | p(HGNC:CAPN2) decreases deg(p(HGNC:HTT, var("?"))) |
| pmid:24027553 | p(HGNC:CAPN2) positiveCorrelation path(MESH:"Neurofibrillary Tangles") |
| pmid:30116051 | p(HGNC:CAST) decreases act(p(HGNC:CAPN1)) |
| pmid:30116051 | p(HGNC:CAST) decreases act(p(HGNC:CAPN2)) |
| pmid:30116051 | p(HGNC:CAST) increases bp(GO:autophagy) |
| pmid:30116051 | p(HGNC:CAST) increases deg(p(HGNC:HTT, var("?"))) |
| pmid:30116051 | p(HGNC:CAST) increases deg(p(HGNC:MAPT)) |
| pmid:30116051 | p(HGNC:CAST) increases deg(p(HGNC:SNCA)) |
| pmid:30116051 | p(HGNC:CAST) increases deg(p(HGNC:SOD1)) |
| pmid:30116051 | a(CHEBI:Calpeptin) decreases act(p(HGNC:CAPN1)) |
| pmid:30116051 | a(CHEBI:Calpeptin) decreases act(p(HGNC:CAPN2)) |
| pmid:30116051 | a(CHEBI:Calpeptin) increases bp(GO:autophagy) |
| pmid:30116051 | a(CHEBI:Calpeptin) increases deg(p(HGNC:HTT, var("?"))) |
| pmid:30116051 | a(CHEBI:"AICA ribonucleotide") increases act(p(FPLX:AMPK)) |
| pmid:30116051 | a(PUBCHEM:54708532) increases act(p(FPLX:AMPK)) |
| pmid:30116051 | a(PUBCHEM:54708532) increases deg(p(HGNC:HTT, var("?"))) |
| pmid:30116051 | a(CHEBI:"selenium(2+)") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:30116051 | a(CHEBI:selenomethionine) increases bp(GO:autophagy) |
| pmid:30116051 | a(CHEBI:selenomethionine) increases act(p(FPLX:AMPK)) |
| pmid:30116051 | a(CHEBI:selenomethionine) increases bp(GO:"autophagosome assembly") |
| pmid:30116051 | a(CHEBI:selenomethionine) increases bp(GO:"lysosomal microautophagy") |
| pmid:29626319 | bp(GO:"lysosomal microautophagy") increases bp(GO:"cellular protein catabolic process") |
| pmid:29626319 | bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | bp(GO:"lysosomal microautophagy") decreases a(HBP:"Tau aggregates") |
| pmid:29626319 | bp(GO:"lysosomal microautophagy") increases p(HGNC:MAPT, frag("?")) |
| pmid:30116051 | a(CHEBI:resveratrol) increases act(p(HGNC:CAMKK2)) |
| pmid:30116051 | a(CHEBI:resveratrol) decreases a(CHEBI:"amyloid-beta") |
| pmid:30116051 | a(CHEBI:resveratrol) decreases p(HGNC:HTT) |
| pmid:30116051 | a(CHEBI:resveratrol) increases act(p(FPLX:AMPK)) |
| pmid:30116051 | a(CHEBI:resveratrol) decreases act(p(HGNC:APP, frag("23_35"))) |
| pmid:30116051 | a(CHEBI:resveratrol) increases r(FPLX:ATG4) |
| pmid:30116051 | a(CHEBI:resveratrol) increases bp(GO:"autophagosome assembly") |
| pmid:30116051 | a(CHEBI:resveratrol) decreases p(HGNC:AGER) |
| pmid:30116051 | a(CHEBI:resveratrol) decreases p(HGNC:MMP9) |
| pmid:30116051 | a(CHEBI:resveratrol) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:29062069 | a(CHEBI:resveratrol) directlyIncreases act(p(HGNC:PPP2CA)) |
| pmid:29062069 | a(CHEBI:resveratrol) directlyDecreases p(HGNC:MID1) |
| pmid:30116051 | p(HGNC:CAMKK2) increases act(p(HGNC:PSMC5)) |
| pmid:30116051 | composite(a(CHEBI:"calcium(2+)"), p(HGNC:CAMKK2)) increases p(FPLX:AMPK, pmod(Ph, Thr, 172)) |
| pmid:30116051 | a(CHEBI:metformin) increases act(p(FPLX:AMPK)) |
| pmid:30116051 | a(CHEBI:metformin) increases bp(GO:autophagy) |
| pmid:30116051 | a(CHEBI:metformin) decreases a(CHEBI:"amyloid-beta") |
| pmid:30116051 | a(CHEBI:metformin) decreases p(HGNC:MAPT, pmod(HBP:HBP00007)) |
| pmid:30116051 | a(CHEBI:metformin) decreases bp(GO:"neuron death") |
| pmid:30116051 | a(CHEBI:"alpha,alpha-trehalose") decreases act(p(HGNC:SLC2A9)) |
| pmid:30116051 | a(CHEBI:"alpha,alpha-trehalose") increases act(p(FPLX:AMPK)) |
| pmid:30116051 | a(CHEBI:"alpha,alpha-trehalose") decreases bp(HP:Neurodegeneration) |
| pmid:30116051 | a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:HBP00006) |
| pmid:30116051 | a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:HBP00016) |
| pmid:30116051 | a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:HBP00017) |
| pmid:30116051 | a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:HBP00018) |
| pmid:30116051 | a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:"motor behavior") |
| pmid:30116051 | a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:cognition) |
| pmid:23528736 | a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) |
| pmid:29626319 | a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) |
| pmid:29626319 | a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) |
| pmid:23528736 | a(CHEBI:"alpha,alpha-trehalose") decreases bp(GO:"neuron apoptotic process") |
| pmid:23528736 | a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:"Tau aggregates") |
| pmid:29626319 | a(CHEBI:"alpha,alpha-trehalose") decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(CHEBI:"alpha,alpha-trehalose") decreases p(HGNC:MAPT) |
| pmid:29626319 | a(CHEBI:"alpha,alpha-trehalose") increases p(HGNC:BAG3) |
| pmid:30116051 | a(CHEBI:"lithium(1+)") decreases act(p(HGNC:IMPA1)) |
| pmid:30116051 | a(CHEBI:"lithium(1+)") decreases a(PUBCHEM:55310) |
| pmid:30116051 | a(CHEBI:"lithium(1+)") increases bp(GO:autophagy) |
| pmid:29626319 | a(CHEBI:"lithium(1+)") increases bp(GO:autophagy) |
| pmid:30116051 | a(CHEBI:"lithium(1+)") decreases p(HGNC:SNCA) |
| pmid:30116051 | a(CHEBI:"lithium(1+)") decreases p(HGNC:SOD1) |
| pmid:30116051 | a(CHEBI:"lithium(1+)") decreases p(HGNC:HTT) |
| pmid:30116051 | a(CHEBI:"lithium(1+)") decreases p(HGNC:MAPT) |
| pmid:30116051 | a(CHEBI:"lithium(1+)") increases bp(GO:"motor behavior") |
| pmid:23528736 | p(HGNC:DCTN4) decreases a(HBP:"Tau aggregates") |
| pmid:30116051 | a(CHEBI:calcitriol) increases act(p(FPLX:AMPK)) |
| pmid:30116051 | a(CHEBI:calcitriol) increases bp(GO:autophagy) |
| pmid:29626319 | a(CHEBI:calcitriol) increases tloc(a(CHEBI:"amyloid-beta polypeptide 40"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) |
| pmid:29626319 | a(CHEBI:calcitriol) decreases p(HGNC:AGER) |
| pmid:29626319 | a(CHEBI:calcitriol) increases p(HGNC:LRP1) |
| pmid:30116051 | complex(a(CHEBI:sirolimus), p(HGNC:FKBP1A)) decreases act(p(FPLX:mTORC1)) |
| pmid:30116051 | a(CHEBI:Temsirolimus) decreases a(HBP:HBP00006) |
| pmid:30116051 | a(CHEBI:Temsirolimus) decreases a(HBP:HBP00017) |
| pmid:30116051 | a(CHEBI:Temsirolimus) increases bp(GO:"motor behavior") |
| pmid:30116051 | a(CHEBI:Temsirolimus) decreases a(HBP:HBP00016) |
| pmid:30116051 | a(CHEBI:Temsirolimus) decreases bp(HP:Neurodegeneration) |
| pmid:30116051 | a(CHEBI:Temsirolimus) decreases p(HGNC:ATXN3, var("?")) |
| pmid:29626319 | a(CHEBI:Temsirolimus) increases bp(GO:autophagy) |
| pmid:29626319 | a(CHEBI:Temsirolimus) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(CHEBI:Temsirolimus) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:23528736 | p(HGNC:ATXN3, var("?")) association path(MESH:"Neurodegenerative Diseases") |
| pmid:30116051 | a(CHEBI:fisetin) increases bp(GO:macroautophagy) |
| pmid:30116051 | a(CHEBI:fisetin) increases act(p(FPLX:mTORC1)) |
| pmid:30116051 | a(CHEBI:fisetin) decreases a(HBP:HBP00018) |
| pmid:29121589 | p(HGNC:NFE2L2) partOf complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) |
| pmid:29121589 | p(HGNC:NFE2L2) positiveCorrelation p(FPLX:AKT) |
| pmid:24355211 | p(HGNC:NFE2L2) increases p(ECCODE:"2.5.1.18") |
| pmid:30116051 | p(HGNC:ABL1) decreases bp(GO:macroautophagy) |
| pmid:17493042 | p(HGNC:ABL1) increases p(HGNC:MAPT, pmod(Ph, Tyr, 394)) |
| pmid:23687953 | act(p(HGNC:ABL1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 363)) |
| pmid:30116051 | a(CHEBI:nilotinib) decreases act(p(HGNC:ABL1)) |
| pmid:30116051 | a(CHEBI:nilotinib) increases bp(GO:macroautophagy) |
| pmid:30116051 | a(CHEBI:nilotinib) decreases bp(HP:Neurodegeneration) |
| pmid:30116051 | a(CHEBI:cilostazol) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:30116051 | a(CHEBI:cilostazol) decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:30116051 | a(CHEBI:cilostazol) increases bp(GO:macroautophagy) |
| pmid:30116051 | a(CHEBI:cilostazol) increases p(HGNC:BECN1) |
| pmid:30116051 | a(CHEBI:cilostazol) increases p(HGNC:ATG5) |
| pmid:30116051 | a(CHEBI:cilostazol) increases p(HGNC:MAP1LC3A) |
| pmid:30116051 | a(CHEBI:cilostazol) decreases p(FPLX:mTORC1) |
| pmid:30116051 | a(CHEBI:cilostazol) increases p(HGNC:CTSB) |
| pmid:30116051 | a(CHEBI:cilostazol) increases act(p(HGNC:SIRT1)) |
| pmid:30116051 | a(CHEBI:cilostazol) increases p(FPLX:AMPK, pmod(Ph, Tyr, 172)) |
| pmid:30116051 | a(CHEBI:cilostazol) increases bp(GO:cognition) |
| pmid:30116051 | a(CHEBI:cilostazol) decreases p(HGNC:MAPT, pmod(HBP:HBP00007)) |
| pmid:30116051 | a(CHEBI:spermidine) decreases p(HGNC:ATG7, pmod(Ac)) |
| pmid:30116051 | a(CHEBI:spermidine) decreases p(FPLX:"Histone_H3", pmod(Ac)) |
| pmid:30116051 | a(CHEBI:spermidine) increases act(p(HGNC:BECN1)) |
| pmid:30116051 | a(CHEBI:spermidine) decreases act(p(HGNC:CASP3)) |
| pmid:30116051 | p(HGNC:BECN1, frag("?")) decreases act(p(HGNC:BECN1)) |
| pmid:30116051 | a(CHEBI:Isorhynchophylline) increases p(HGNC:BECN1) |
| pmid:30116051 | a(CHEBI:Isorhynchophylline) decreases a(HBP:HBP00016) |
| pmid:30116051 | complex(p(HGNC:BCL2), p(HGNC:BECN1)) decreases bp(GO:macroautophagy) |
| pmid:30116051 | a(PUBCHEM:16240819) decreases act(p(HGNC:MTMR14)) |
| pmid:30116051 | a(PUBCHEM:16240819) increases bp(GO:macroautophagy) |
| pmid:30116051 | a(PUBCHEM:16240819) decreases bp(HP:Neurodegeneration) |
| pmid:30116051 | p(HGNC:MTMR14) decreases act(p(FPLX:PI3K)) |
| pmid:30116051 | a(CHEBI:paclitaxel) increases a(GO:microtubule) |
| pmid:22941973 | a(CHEBI:paclitaxel) negativeCorrelation act(p(INTERPRO:"14-3-3 domain")) |
| pmid:22941973 | a(CHEBI:paclitaxel) decreases p(RGD:Mapt, pmod(Ph, Ser, 262)) |
| pmid:30116051 | a(CHEBI:"epothilone A") increases a(GO:microtubule) |
| pmid:30116051 | a(CHEBI:"epothilone D") increases a(GO:microtubule) |
| pmid:30116051 | a(CHEBI:"epothilone D") increases bp(GO:cognition) |
| pmid:30116051 | act(p(HGNC:RAB5A)) decreases bp(HP:Neurodegeneration) |
| pmid:27607061 | act(p(HGNC:RAB5A)) negativeCorrelation surf(p(HGNC:GRIK2)) |
| pmid:27607061 | act(p(HGNC:RAB5A)) partOf bp(GO:"clathrin-dependent endocytosis") |
| pmid:30116051 | a(PUBCHEM:129688311) increases bp(GO:"lysosomal lumen acidification") |
| pmid:30116051 | a(PUBCHEM:129688311) decreases a(HBP:HBP00016) |
| pmid:30116051 | a(PUBCHEM:129688311) decreases a(CHEBI:"amyloid-beta") |
| pmid:30116051 | a(CHEBI:"poly(lactic acid) polymer") increases bp(GO:"lysosomal lumen acidification") |
| pmid:30116051 | a(CHEBI:"poly(D,L-lactic acid-co-glycolic acid)") increases bp(GO:"lysosomal lumen acidification") |
| pmid:30116051 | a(PUBCHEM:2880983) increases act(p(HGNC:MCOLN1)) |
| pmid:30116051 | act(p(HGNC:MCOLN1)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:Lysosomes), toLoc(MESH:Cytoplasm)) |
| pmid:30116051 | act(p(HGNC:MCOLN1)) increases bp(GO:"lysosomal lumen acidification") |
| pmid:30116051 | act(p(HGNC:MCOLN1)) decreases a(CHEBI:"amyloid-beta") |
| pmid:30116051 | a(CHEBI:chlorohydroquinone) decreases bp(GO:macroautophagy) |
| pmid:30116051 | a(CHEBI:"5-chloro-7-iodoquinolin-8-ol") increases bp(GO:macroautophagy) |
| pmid:30116051 | a(CHEBI:"5-chloro-7-iodoquinolin-8-ol") decreases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:30116051 | a(CHEBI:ambroxol) increases p(HGNC:GBA) |
| pmid:30116051 | a(CHEBI:ambroxol) increases bp(GO:macroautophagy) |
| pmid:30116051 | a(CHEBI:ambroxol) increases deg(p(HGNC:SNCA)) |
| pmid:30116051 | a(CHEBI:ambroxol) decreases p(HGNC:SNCA) |
| pmid:30116051 | a(CHEBI:ambroxol) decreases bp(GO:"response to endoplasmic reticulum stress") |
| pmid:30116051 | a(PUBCHEM:9568077) increases act(p(HGNC:HSF1), ma(tscript)) |
| pmid:30116051 | a(PUBCHEM:46216556) decreases act(p(FPLX:HSP90)) |
| pmid:30116051 | a(PUBCHEM:46216556) decreases a(HBP:HBP00017) |
| pmid:30116051 | a(PUBCHEM:3086599) increases act(complex(GO:"proteasome complex")) |
| pmid:30116051 | a(PUBCHEM:3086599) increases act(p(FPLX:PKA), ma(kin)) |
| pmid:30116051 | complex(p(HGNC:BIRC2), p(HGNC:SOD1)) increases deg(p(HGNC:SOD1)) |
| pmid:23702978 | p(HGNC:BIRC2) decreases complex(GO:ripoptosome) |
| pmid:30116051 | p(HGNC:LAMP2) increases bp(GO:"chaperone-mediated autophagy") |
| pmid:30116051 | p(HGNC:LAMP2) increases deg(p(HGNC:SNCA)) |
| pmid:30116051 | p(HGNC:SESN2) increases act(p(FPLX:AMPK)) |
| pmid:30116051 | p(HGNC:SESN2) increases bp(GO:macroautophagy) |
| pmid:30116051 | p(HGNC:SESN2) increases bp(GO:macroautophagy) |
| pmid:30116051 | p(HGNC:PLG) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pmid:30116051 | p(HGNC:PLG) increases deg(p(HGNC:SNCA)) |
| pmid:30116051 | p(HGNC:KLK6) increases deg(p(HGNC:SNCA)) |
| pmid:30116051 | a(CHEBI:"(-)-epigallocatechin") increases p(HGNC:IDE) |
| pmid:30116051 | a(CHEBI:"(-)-epigallocatechin") increases sec(p(HGNC:IDE)) |
| pmid:30116051 | a(CHEBI:"(-)-epigallocatechin") increases act(p(HGNC:IDE)) |
| pmid:30116051 | a(CHEBI:"(-)-epigallocatechin") increases p(HGNC:MME) |
| pmid:30116051 | a(CHEBI:"(-)-epigallocatechin") increases sec(p(HGNC:MME)) |
| pmid:30116051 | a(CHEBI:"(-)-epigallocatechin") increases act(p(HGNC:MME)) |
| pmid:30116051 | a(CHEBI:somatostatin) increases p(HGNC:IDE) |
| pmid:30116051 | a(CHEBI:somatostatin) increases sec(p(HGNC:IDE)) |
| pmid:30116051 | a(CHEBI:somatostatin) increases act(p(HGNC:IDE)) |
| pmid:29626319 | a(CHEBI:somatostatin) increases p(HGNC:IDE) |
| pmid:30116051 | a(CHEBI:somatostatin) increases p(HGNC:MME) |
| pmid:30116051 | a(CHEBI:somatostatin) increases sec(p(HGNC:MME)) |
| pmid:30116051 | a(CHEBI:somatostatin) increases act(p(HGNC:MME)) |
| pmid:29626319 | a(CHEBI:somatostatin) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:30116051 | p(HGNC:GRN) increases act(p(HGNC:MME)) |
| pmid:30116051 | p(HGNC:GRN) decreases a(HBP:HBP00018) |
| pmid:30116051 | a(CHEBI:rifampicin) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pmid:30116051 | a(CHEBI:rifampicin) increases act(p(HGNC:LRP1)) |
| pmid:30116051 | a(CHEBI:rifampicin) increases act(p(FPLX:"GPIb_IX_V")) |
| pmid:26195256 | p(HGNC:AGER) increases tloc(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:AGER) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:18494933 | act(p(HGNC:AGER)) positiveCorrelation p(FPLX:JNK) |
| pmid:25681682 | p(HGNC:AGER) negativeCorrelation bp(GO:aging) |
| pmid:25681682 | p(HGNC:AGER) negativeCorrelation bp(MESH:"Body Mass Index") |
| pmid:24183963 | act(p(HGNC:AGER)) increases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:18494933 | act(p(HGNC:AGER)) increases p(HGNC:MAPK8, pmod(Ph)) |
| pmid:30116051 | act(p(HGNC:AQP4)) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:AQP4) association deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:AQP4) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | p(HGNC:AQP4) decreases a(CHEBI:"amyloid-beta") |
| pmid:26195256 | act(p(HGNC:AQP4)) decreases p(CHEBI:"amyloid-beta", loc(GO:"extracellular region")) |
| pmid:29626319 | p(HGNC:AQP4) increases a(HP:"glymphatic system") |
| pmid:29626319 | p(HGNC:AQP4) increases a(HP:"glymphatic system") |
| pmid:23484434 | a(CHEBI:6872) decreases a(HBP:HBP00006) |
| pmid:23484434 | a(CHEBI:8028) causesNoChange a(HBP:HBP00006) |
| pmid:23484434 | a(CHEBI:44932) causesNoChange a(HBP:HBP00006) |
| pmid:23484434 | a(CHEBI:3647) causesNoChange a(HBP:HBP00006) |
| pmid:23484434 | a(CHEBI:87637) decreases a(HBP:HBP00006) |
| pmid:23484434 | a(CHEBI:22580) decreases a(HBP:HBP00006) |
| pmid:23484434 | a(CHEBI:1457) decreases a(HBP:HBP00018) |
| pmid:23484434 | a(CHEBI:10642) decreases a(HBP:HBP00018) |
| pmid:23484434 | a(CHEBI:4806) decreases a(HBP:HBP00018) |
| pmid:23484434 | a(CHEBI:4806) decreases a(HBP:HBP00006) |
| pmid:23484434 | a(CHEBI:74460) decreases a(HBP:HBP00018) |
| pmid:23484434 | a(HBP:HBP00021) decreases a(HBP:HBP00018) |
| pmid:23484434 | a(HBP:HBP00019) decreases a(HBP:HBP00018) |
| pmid:23484434 | a(CHEBI:90) causesNoChange a(HBP:HBP00006) |
| pmid:23484434 | a(CHEBI:18152) decreases a(HBP:HBP00006) |
| pmid:23484434 | a(CHEBI:3441) decreases a(HBP:HBP00018) |
| pmid:23484434 | a(CHEBI:3441) decreases a(HBP:HBP00006) |
| pmid:23484434 | a(CHEBI:6710) decreases a(HBP:HBP00006) |
| pmid:23484434 | a(CHEBI:6710) decreases a(HBP:HBP00018) |
| pmid:23484434 | a(CHEBI:112284) decreases a(HBP:HBP00006) |
| pmid:23484434 | a(HBP:HBP00020) decreases a(HBP:HBP00006) |
| pmid:29024336 | path(MESH:"Proteostasis Deficiencies") decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) |
| pmid:29024336 | path(MESH:Tauopathies) increases path(MESH:"Proteostasis Deficiencies") |
| pmid:24027553 | path(MESH:Tauopathies) positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pmid:27574109 | path(MESH:Tauopathies) positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:29686391 | path(MESH:Tauopathies) positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:27574109 | path(MESH:Tauopathies) positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:21734277 | path(MESH:Tauopathies) association p(HBP:"AT8 tau", pmod(Ph)) |
| pmid:30108137 | path(MESH:Tauopathies) increases p(MGI:Tfeb) |
| pmid:30108137 | path(MESH:Tauopathies) increases p(MGI:Tfeb) |
| pmid:30108137 | path(MESH:Tauopathies) increases p(MGI:Lamp1) |
| pmid:30108137 | path(MESH:Tauopathies) increases p(MGI:Ctsd) |
| pmid:21882945 | path(MESH:Tauopathies) positiveCorrelation bp(GO:"neuron death") |
| pmid:28420982 | path(MESH:Tauopathies) association bp(GO:"neuron death") |
| pmid:21882945 | path(MESH:Tauopathies) negativeCorrelation bp(GO:cognition) |
| pmid:30126037 | path(MESH:Tauopathies) association bp(GO:"cellular senescence") |
| pmid:30126037 | path(MESH:Tauopathies) association path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:22419736 | path(MESH:Tauopathies) association a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:28420982 | path(MESH:Tauopathies) association a(HBP:"Tau annular protofibrils") |
| pmid:29024336 | p(MGI:Mapt) decreases bp(GO:"late endosomal microautophagy") |
| pmid:29202785 | p(MGI:Mapt) increases bp(GO:"neuron migration") |
| pmid:29202785 | p(MGI:Mapt) increases bp(GO:"neuron differentiation") |
| pmid:29202785 | p(MGI:Mapt) increases bp(GO:"neuron maturation") |
| pmid:30126037 | p(MGI:Mapt) increases a(GO:"neurofibrillary tangle") |
| pmid:30126037 | p(MGI:Mapt) increases bp(HP:Neurodegeneration) |
| pmid:30126037 | p(MGI:Mapt) increases p(MGI:Cdkn2a) |
| pmid:30126037 | p(MGI:Mapt) increases bp(GO:"cellular senescence") |
| pmid:30126037 | p(MGI:Mapt) increases path(HP:"Brain atrophy") |
| pmid:28408124 | tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) increases a(HBP:"Tau aggregates") |
| pmid:18096814 | p(MGI:Mapt) negativeCorrelation a(CHEBI:"2-bromohexadecanoic acid") |
| pmid:26400044 | p(MGI:Mapt) increases complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) |
| pmid:25995053 | p(MGI:Mapt) association p(MGI:Dapk1) |
| pmid:25995053 | p(MGI:Mapt) partOf complex(p(MGI:Dapk1), p(MGI:Mapt)) |
| pmid:29221819 | p(MGI:Mapt) negativeCorrelation p(MGI:Dyrk1a) |
| pmid:28877763 | p(MGI:Mapt) positiveCorrelation p(MGI:Syk) |
| pmid:29024336 | bp(GO:"late endosomal microautophagy") increases deg(p(MGI:Mapt)) |
| pmid:29024336 | bp(GO:"late endosomal microautophagy") increases deg(p(MGI:Mapt)) |
| pmid:29024336 | bp(GO:"late endosomal microautophagy") increases deg(a(HBP:HBP00053)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Mapt) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases a(HBP:HBP00006) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases a(HBP:HBP00100) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) decreases complex(a(GO:lysosome), p(MGI:Mapt)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) decreases complex(a(GO:lysosome), p(MGI:Mapt)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) decreases bp(GO:"late endosomal microautophagy") |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases deg(a(MESH:Proteins)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases deg(a(MESH:Proteins)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"chaperone-mediated autophagy") |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases a(GO:autophagosome) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases a(GO:autolysosome) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:macroautophagy) |
| pmid:29024336 | p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:macroautophagy) |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:H2afx) |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cdkn1a) |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cdkn2a) |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Il1b) |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cxcl1) |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Tnf) |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Tlr4) |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"NIK/NF-kappaB signaling") |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Rela) |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Glb1) |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases path(MESH:Tauopathies) |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases a(GO:"neurofibrillary tangle") |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"cellular senescence") |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) association bp(MESH:"Cerebrovascular Circulation") |
| pmid:30126037 | p(MGI:Mapt, var("p.Pro301Leu")) increases bp(MESH:"Cerebrovascular Circulation") |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases p(MGI:Mapt) |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases a(HBP:HBP00009) |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) decreases bp(GO:"late endosomal microautophagy") |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) decreases bp(GO:"late endosomal microautophagy") |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt, var("p.Ala152Thr"))) |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases deg(a(MESH:Proteins)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases deg(a(MESH:Proteins)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases deg(a(MESH:Proteins)) |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases bp(GO:"chaperone-mediated autophagy") |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases a(GO:autophagosome) |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases a(GO:autolysosome) |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases bp(GO:macroautophagy) |
| pmid:29024336 | p(MGI:Mapt, var("p.Ala152Thr")) increases bp(GO:macroautophagy) |
| pmid:29024336 | complex(a(GO:lysosome), p(MGI:Mapt, var("p.Pro301Leu"))) increases tloc(p(MGI:Mapt, var("p.Pro301Leu")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | complex(a(GO:lysosome), p(MGI:Snca, var("?"))) decreases tloc(p(MGI:Snca, var("?")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | complex(a(GO:lysosome), p(MGI:Lrrk2, var("?"))) decreases tloc(p(MGI:Lrrk2, var("?")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | a(GO:"late endosome") increases deg(p(MGI:Mapt)) |
| pmid:29024336 | a(GO:"late endosome") decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) |
| pmid:29024336 | a(GO:"late endosome") decreases deg(p(MGI:Mapt, var("p.Ala152Thr"))) |
| pmid:29590627 | a(GO:"late endosome") association p(HGNC:MAPT, var("p.Pro301Ser")) |
| pmid:29590627 | a(GO:"late endosome") association a(HBP:"Tau aggregates") |
| pmid:29024336 | a(CHEBI:paraquat) increases bp(GO:"response to oxidative stress") |
| pmid:28019679 | a(CHEBI:paraquat) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:28019679 | a(CHEBI:paraquat) increases p(HGNC:CASP1) |
| pmid:28019679 | a(CHEBI:paraquat) increases p(HGNC:IL1B) |
| pmid:29024336 | composite(a(CHEBI:thapsigargin), a(HBP:HBP00053)) increases bp(GO:"chaperone-mediated autophagy") |
| pmid:29024336 | composite(a(CHEBI:paraquat), a(HBP:HBP00053)) increases bp(GO:"chaperone-mediated autophagy") |
| pmid:29024336 | composite(a(CHEBI:paraquat), p(MGI:Mapt, var("p.Pro301Leu"))) decreases bp(GO:"chaperone-mediated autophagy") |
| pmid:29024336 | composite(a(CHEBI:thapsigargin), p(MGI:Mapt, var("p.Pro301Leu"))) decreases bp(GO:"chaperone-mediated autophagy") |
| pmid:29024336 | composite(a(CHEBI:thapsigargin), p(MGI:Mapt, var("p.Ala152Thr"))) causesNoChange bp(GO:"chaperone-mediated autophagy") |
| pmid:29024336 | composite(a(CHEBI:paraquat), p(MGI:Mapt, var("p.Ala152Thr"))) causesNoChange bp(GO:"chaperone-mediated autophagy") |
| pmid:29024336 | composite(a(CHEBI:"ammonium chloride"), a(CHEBI:leupeptin)) decreases bp(GO:"late endosomal microautophagy") |
| pmid:23528736 | a(CHEBI:leupeptin) decreases act(p(FPLX:Proteasome)) |
| pmid:23528736 | a(CHEBI:leupeptin) decreases deg(p(HGNC:MAPT)) |
| pmid:29024336 | a(HBP:HBP00057) increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | a(HBP:HBP00057) increases bp(GO:"chaperone-mediated autophagy") |
| pmid:29024336 | a(HBP:HBP00055) increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | a(HBP:HBP00055) decreases deg(p(MGI:Mapt)) |
| pmid:29024336 | a(HBP:HBP00055) decreases bp(GO:"late endosomal microautophagy") |
| pmid:29024336 | a(HBP:HBP00054) decreases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | p(HBP:HBP00053, var("p.Lys280del")) increases a(HBP:HBP00006) |
| pmid:29024336 | p(HBP:HBP00053, var("p.Lys280del")) decreases deg(p(HGNC:MAPT)) |
| pmid:29024336 | p(HBP:HBP00053, var("p.Lys280del")) decreases tloc(p(HBP:HBP00053, var("p.Lys280del")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | p(HBP:HBP00053, var("p.Lys280delinsProPro")) increases tloc(p(HBP:HBP00053, var("p.Lys280del")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | p(HBP:HBP00053, var("p.Lys280delinsProPro")) decreases a(HBP:HBP00006) |
| pmid:29024336 | p(HBP:HBP00053, var("p.Lys280delinsProPro")) decreases tloc(p(HBP:HBP00053, var("p.Lys280Pro")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | bp(GO:"protein oxidation") increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:"multivesicular body")) |
| pmid:29024336 | p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) decreases tloc(p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) decreases deg(p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))) |
| pmid:29024336 | p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) decreases tloc(p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) decreases deg(p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212))) |
| pmid:29024336 | p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) decreases tloc(p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) decreases deg(p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))) |
| pmid:29024336 | p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) decreases tloc(p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29024336 | p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) decreases deg(p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))) |
| pmid:29024336 | p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")) increases tloc(p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) |
| pmid:29215007 | a(HBP:HBP00166) increases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:29215007 | complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) positiveCorrelation a(HBP:HBP00169) |
| pmid:29215007 | composite(complex(GO:"filamentous actin"), p(HGNC:CFL1)) decreases complex(GO:"filamentous actin") |
| pmid:24760868 | complex(GO:"filamentous actin") association p(HGNC:MAPT) |
| pmid:24760868 | complex(GO:"filamentous actin") increases p(HGNC:MAPT) |
| pmid:24760868 | complex(GO:"filamentous actin") increases p(HGNC:MAPT, loc(GO:synapse)) |
| pmid:17187063 | complex(GO:"filamentous actin") increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:29215007 | a(HBP:HBP00169) positiveCorrelation complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:29215007 | a(HBP:HBP00169) positiveCorrelation complex(a(GO:"filamentous actin"), p(HGNC:CFL1)) |
| pmid:29215007 | a(HBP:HBP00169) positiveCorrelation complex(a(MESH:Actins), p(HGNC:CFL1)) |
| pmid:29215007 | complex(a(GO:"filamentous actin"), p(HGNC:CFL1)) positiveCorrelation a(HBP:HBP00169) |
| pmid:29215007 | complex(a(MESH:Actins), p(HGNC:CFL1)) positiveCorrelation a(HBP:HBP00169) |
| pmid:29215007 | a(MESH:Endopeptidases) increases p(HGNC:MAPT, var("?")) |
| pmid:29215007 | p(HGNC:MAPT, frag("244_372")) increases bp(GO:"actin filament bundle assembly") |
| pmid:29215007 | p(HGNC:MAPT, frag("254_290")) increases bp(GO:"actin filament bundle assembly") |
| pmid:29215007 | p(HGNC:MAPT, frag("254_290")) increases bp(GO:"actin filament bundle assembly") |
| pmid:29215007 | p(HGNC:MAPT, frag("254_290")) increases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) |
| pmid:29215007 | p(HGNC:MAPT, frag("260_268")) increases bp(MESH:"Protein Structure, Secondary") |
| pmid:29215007 | p(HGNC:MAPT, frag("277_283")) increases bp(MESH:"Protein Structure, Secondary") |
| pmid:29215007 | p(HGNC:MAPT, frag("277_283")) increases bp(MESH:"Protein Conformation, alpha-Helical") |
| pmid:29215007 | p(HGNC:MAPT, frag("261_268")) increases bp(MESH:"Protein Conformation, alpha-Helical") |
| pmid:22072628 | bp(MESH:"Protein Conformation, alpha-Helical") positiveCorrelation p(HBP:"proline-rich region 2", pmod(Ph)) |
| pmid:22072628 | bp(MESH:"Protein Conformation, alpha-Helical") association p(HGNC:MAPT, frag("235_324")) |
| pmid:29215007 | p(HGNC:MAPT, frag("277_280")) increases a(HBP:HBP00170) |
| pmid:29215007 | p(HGNC:MAPT, frag("261_265")) increases a(HBP:HBP00170) |
| pmid:29215007 | complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("261_268"))) increases bp(MESH:"Protein Conformation, alpha-Helical") |
| pmid:29215007 | complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("277_280"))) increases a(HBP:HBP00170) |
| pmid:29215007 | complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("261_265"))) increases a(HBP:HBP00170) |
| pmid:29215007 | complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("277_283"))) increases bp(MESH:"Protein Conformation, alpha-Helical") |
| pmid:29215007 | p(HGNC:MAPT, var("p.Leu256Glu")) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) |
| pmid:29215007 | p(HGNC:MAPT, var("p.Leu256Glu")) decreases bp(GO:"actin filament bundle assembly") |
| pmid:29215007 | complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) increases bp(MESH:"Protein Conformation, alpha-Helical") |
| pmid:29215007 | p(HGNC:MAPT, frag("292_319")) increases bp(GO:"actin filament bundle assembly") |
| pmid:29215007 | p(HGNC:MAPT, frag("315_318")) increases a(HBP:HBP00170) |
| pmid:29215007 | complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_268"))) increases bp(MESH:"Protein Conformation, alpha-Helical") |
| pmid:29215007 | p(HGNC:MAPT, frag("254_268")) decreases bp(GO:"actin filament bundle assembly") |
| pmid:29215007 | act(p(HGNC:MARK2), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:29215007 | p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:21311567 | act(p(HGNC:MARK2)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:24251416 | act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:23001711 | act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:29215007 | act(p(HGNC:MARK2), ma(kin)) increases p(HBP:HBP00098, pmod(Ph)) |
| pmid:29215007 | p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 293)) |
| pmid:24251416 | act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 293)) |
| pmid:29215007 | p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 305)) |
| pmid:24251416 | act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 305)) |
| pmid:29215007 | p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 324)) |
| pmid:24251416 | act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 324)) |
| pmid:29215007 | p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 356)) |
| pmid:24251416 | act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 356)) |
| pmid:29215007 | p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 416)) |
| pmid:24251416 | act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 416)) |
| pmid:21882945 | act(p(HGNC:MARK2)) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:21882945 | act(p(HGNC:MARK2)) directlyIncreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:21311567 | act(p(HGNC:MARK2)) decreases bp(GO:"microtubule polymerization") |
| pmid:24251416 | act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 352)) |
| pmid:24251416 | act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 413)) |
| pmid:25031639 | p(HGNC:MARK2) increases a(HBP:"Tau epitope, 12E8") |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases bp(GO:"actin filament bundle assembly") |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases bp(GO:"actin filament bundle assembly") |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_284"))) |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:17493042 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) |
| pmid:17493042 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases bp(GO:"neurofibrillary tangle assembly") |
| pmid:21367866 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation p(HGNC:CDC37) |
| pmid:11943212 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation p(HGNC:MARK4, pmod(Ph)) |
| pmid:11943212 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation a(HBP:"granulovacuolar degeneration") |
| pmid:22692785 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) partOf a(GO:"neurofibrillary tangle") |
| pmid:22156579 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin)) |
| pmid:22156579 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) partOf a(HBP:"Tau epitope, 12E8") |
| pmid:23948915 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) negativeCorrelation bp(GO:"apoptotic process") |
| pmid:26118667 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) negativeCorrelation m(MIRBASE:"rno-mir-195") |
| pmid:22833681 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) |
| pmid:22952452 | p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation a(HBP:Neurodegeneration) |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases bp(GO:"actin filament bundle assembly") |
| pmid:17493042 | p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) |
| pmid:17493042 | p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases bp(GO:"neurofibrillary tangle assembly") |
| pmid:24251416 | p(HGNC:MAPT, pmod(Ph, Ser, 293)) partOf p(HBP:"tubulin-binding repeat 2") |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 305)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 305)) decreases bp(GO:"actin filament bundle assembly") |
| pmid:24251416 | p(HGNC:MAPT, pmod(Ph, Ser, 305)) partOf p(HBP:"tubulin-binding repeat 2") |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases bp(GO:"actin filament bundle assembly") |
| pmid:17493042 | p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) |
| pmid:17493042 | p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases bp(GO:"neurofibrillary tangle assembly") |
| pmid:28760828 | p(HGNC:MAPT, pmod(Ph, Ser, 324)) positiveCorrelation p(HBP:"Tau aggregates") |
| pmid:28760828 | p(HGNC:MAPT, pmod(Ph, Ser, 324)) positiveCorrelation p(HGNC:HDAC6) |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases bp(GO:"actin filament bundle assembly") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:17493042 | p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) |
| pmid:17493042 | p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases bp(GO:"neurofibrillary tangle assembly") |
| pmid:21367866 | p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation p(HGNC:CDC37) |
| pmid:22156579 | p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin)) |
| pmid:22156579 | p(HGNC:MAPT, pmod(Ph, Ser, 356)) partOf a(HBP:"Tau epitope, 12E8") |
| pmid:22833681 | p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 416)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:29215007 | p(HGNC:MAPT, pmod(Ph, Ser, 416)) decreases bp(GO:"actin filament bundle assembly") |
| pmid:24027553 | p(HGNC:MAPT, pmod(Ac)) association path(MESH:"Neurofibrillary Tangles") |
| pmid:29540553 | p(HGNC:MAPT, pmod(Ac)) negativeCorrelation p(MGI:Sirt3) |
| pmid:27041503 | p(HGNC:MAPT, pmod(Ac)) decreases p(HGNC:WWC1) |
| pmid:20869593 | p(HGNC:MAPT, pmod(Ac)) negativeCorrelation act(p(HGNC:SIRT1)) |
| pmid:20869593 | p(HGNC:MAPT, pmod(Ac)) positiveCorrelation p(HBP:"Tau epitope, AT8") |
| pmid:24027553 | p(HGNC:MAPT, pmod(HBP:nitration)) association path(MESH:"Neurofibrillary Tangles") |
| pmid:24027553 | p(HGNC:MAPT, frag("1_?")) association path(MESH:"Neurofibrillary Tangles") |
| pmid:24027553 | p(HGNC:MAPT, frag("?_*")) association path(MESH:"Neurofibrillary Tangles") |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Aminopeptidases)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | a(CHEBI:Thrombin) increases bp(GO:coagulation) |
| pmid:24027553 | a(CHEBI:Thrombin) increases bp(HBP:"neurite retraction") |
| pmid:24027553 | a(CHEBI:Thrombin) increases bp(GO:"apoptotic process") |
| pmid:24027553 | a(CHEBI:Thrombin) increases bp(GO:"apoptotic process") |
| pmid:24027553 | a(CHEBI:Thrombin) increases a(HBP:"Tau aggregates") |
| pmid:24027553 | a(CHEBI:Thrombin) association path(MESH:"Neurofibrillary Tangles") |
| pmid:24027553 | act(a(CHEBI:Thrombin)) increases p(HGNC:MAPT, frag("1_?")) |
| pmid:24027553 | act(a(CHEBI:Thrombin)) causesNoChange p(HGNC:MAPT, frag("561_685")) |
| pmid:24027553 | act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT, frag("561_685"))) |
| pmid:24027553 | act(a(CHEBI:Thrombin)) increases act(p(HGNCGENEFAMILY:Caspases)) |
| pmid:24027553 | act(p(HGNC:HTRA1)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(p(HGNC:HTRA1)) increases deg(p(HGNC:MAPT)) |
| pmid:29626319 | p(HGNC:HTRA1) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | p(HGNC:HTRA1) association bp(HBP:"APP processing") |
| pmid:24027553 | act(p(HGNC:HTRA1)) increases deg(p(HGNCGENEFAMILY:Tubulins)) |
| pmid:24027553 | act(p(HGNC:HTRA1)) association act(a(MESH:Microtubules)) |
| pmid:24027553 | act(p(HGNC:HTRA1)) increases deg(a(HBP:"Tau fibrils")) |
| pmid:24027553 | act(p(HGNC:HTRA1)) increases deg(a(HBP:"Tau aggregates")) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Calpains)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Calpains)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Calpains)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | p(HGNCGENEFAMILY:Calpains) association path(MESH:"Neurodegenerative Diseases") |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("?", "35kD")) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("?", "17kD")) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("?", "17kD")) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Calpains)) association a(HBP:Excitotoxicity) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Calpains)) increases path(HBP:Neurodegeneration) |
| pmid:24027553 | act(p(HGNC:NPEPPS)) association a(MESH:Brain) |
| pmid:24027553 | p(HGNC:NPEPPS) positiveCorrelation p(MGI:Mapt, var("p.P301L")) |
| pmid:24027553 | p(HGNC:NPEPPS) decreases p(MGI:Mapt, var("p.P301L")) |
| pmid:24027553 | p(HGNC:NPEPPS) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:24027553 | p(HGNC:NPEPPS) decreases path(MESH:Tauopathies) |
| pmid:24027553 | p(HGNC:NPEPPS) decreases p(HGNC:MAPT) |
| pmid:24027553 | p(HGNC:NPEPPS) regulates deg(p(HGNC:MAPT)) |
| pmid:24027553 | p(HGNC:NPEPPS) decreases path(MESH:Paralysis) |
| pmid:24027553 | p(HGNC:NPEPPS) decreases path(MESH:Gliosis) |
| pmid:24027553 | p(HGNC:NPEPPS) increases p(HGNC:MAPT, frag("1_?")) |
| pmid:24027553 | p(HGNC:NPEPPS) increases p(HGNC:MAPT, frag("?_*")) |
| pmid:24027553 | p(HGNC:NPEPPS) association bp(GO:autophagy) |
| pmid:24027553 | p(HGNC:MAPT, var("p.P301L")) association path(MESH:"Frontotemporal Dementia") |
| pmid:24027553 | p(MGI:Mapt, var("p.P301L")) association path(HBP:Neurodegeneration) |
| pmid:24027553 | p(MGI:Mapt, var("p.P301L")) positiveCorrelation p(HGNC:NPEPPS) |
| pmid:24027553 | p(HGNC:PIN1) association path(MESH:"Alzheimer Disease") |
| pmid:24027553 | p(HGNC:PIN1) decreases deg(p(HGNC:MAPT, var("p.P301L"))) |
| pmid:26751493 | p(HGNC:PIN1) association p(HBP:"projection domain") |
| pmid:26751493 | p(HGNC:PIN1) association a(HBP:"projection domain") |
| pmid:25899010 | p(HGNC:PIN1) decreases a(HBP:Excitotoxicity) |
| pmid:25899010 | p(HGNC:PIN1) negativeCorrelation p(HGNC:DAPK1) |
| pmid:24964035 | p(HGNC:PIN1) increases deg(p(HGNC:SMAD2)) |
| pmid:24964035 | p(HGNC:PIN1) increases complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:SMAD2)) |
| pmid:23157676 | act(p(HGNC:PIN1)) decreases p(HBP:"cis p-tau") |
| pmid:26996941 | act(p(HGNC:PIN1)) association p(HGNC:MAPT, pmod(Ph, Ser, 235)) |
| pmid:22926167 | act(p(HGNC:PIN1)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:19401603 | act(p(HGNC:PIN1)) positiveCorrelation act(p(HGNC:PPP2CA)) |
| pmid:19401603 | act(p(HGNC:PIN1)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 212)) |
| pmid:24027553 | deg(p(HGNC:MAPT, frag("561_685"))) increases a(HBP:"Tau aggregates") |
| pmid:24027553 | p(HGNC:MAPT, frag("561_685")) increases a(HBP:"Tau aggregates") |
| pmid:24027553 | p(HBP:"cis p-tau") decreases deg(p(HBP:"cis p-tau")) |
| pmid:24027553 | p(HBP:"cis p-tau") decreases act(p(HGNC:PIN1)) |
| pmid:23157676 | p(HBP:"cis p-tau") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23157676 | p(HBP:"cis p-tau") increases a(HBP:"Tau aggregates") |
| pmid:23157676 | p(HBP:"cis p-tau") partOf a(HBP:"dystrophic neurite") |
| pmid:24027553 | act(a(MESH:Microtubules)) association act(p(HGNC:HTRA1)) |
| pmid:29238289 | act(a(MESH:Microtubules)) association p(HGNC:MAPT) |
| pmid:29686391 | a(HBP:"Tau fibrils") causesNoChange tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28420982 | a(HBP:"Tau fibrils") increases a(GO:"neurofibrillary tangle") |
| pmid:24027553 | p(HGNC:MAPT, frag("?", "17kD")) association bp(GO:"apoptotic process") |
| pmid:24027553 | p(HGNC:MAPT, frag("?", "17kD")) increases bp(HBP:"neurite retraction") |
| pmid:24027553 | p(HGNC:MAPT, frag("?", "17kD")) causesNoChange path(HBP:neurotoxicity) |
| pmid:24027553 | a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "17kD")) |
| pmid:24027553 | a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "35kD")) |
| pmid:24027553 | a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "24kD")) |
| pmid:24027553 | a(CHEBI:"calpain inhibitor") decreases act(p(HGNCGENEFAMILY:Calpains)) |
| pmid:24027553 | act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("?_*")) |
| pmid:24027553 | act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("?_*")) |
| pmid:24027553 | act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("1_?")) |
| pmid:24027553 | act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("1_?")) |
| pmid:24027553 | act(p(HGNC:CASP6)) increases bp(GO:"apoptotic process") |
| pmid:24027553 | act(p(HGNC:CASP6)) increases p(HGNC:MAPT, var("p.D421*")) |
| pmid:24027553 | act(p(HGNC:CASP6)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24027553 | p(HGNC:MAPT, var("p.D421*")) isA p(HBP:"Tau C3") |
| pmid:24027553 | p(HBP:"Tau C3") increases bp(GO:"apoptotic process") |
| pmid:24027553 | p(HBP:"Tau C3") increases a(HBP:"Tau aggregates") |
| pmid:24027553 | p(HBP:"Tau C3") increases a(HBP:"Tau aggregates") |
| pmid:24027553 | p(HBP:"Tau C3") negativeCorrelation bp(GO:cognition) |
| pmid:24027553 | p(HGNC:MAPT, var("p.D421E")) decreases bp(GO:"apoptotic process") |
| pmid:24027553 | composite(p(HBP:"amyloid-beta oligomers"), p(HGNC:CASP3)) increases p(HBP:"Tau C3") |
| pmid:24027553 | a(MESH:"9-deoxy-delta-9-prostaglandin D2") increases act(p(HGNCGENEFAMILY:Caspases)) |
| pmid:24027553 | a(CHEBI:epoxomicin) increases act(p(HGNC:CASP3)) |
| pmid:24027553 | a(CHEBI:epoxomicin) decreases deg(p(HGNC:MAPT)) |
| pmid:24027553 | a(CHEBI:epoxomicin) increases p(HGNC:MAPT) |
| pmid:23528736 | a(CHEBI:epoxomicin) decreases deg(p(HGNC:MAPT)) |
| pmid:23528736 | a(CHEBI:epoxomicin) decreases act(p(FPLX:Proteasome)) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT, pmod(Ub))) |
| pmid:24027553 | p(HGNCGENEFAMILY:Proteasome) increases deg(p(HGNC:MAPT, pmod(Ub))) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | p(HGNCGENEFAMILY:Proteasome) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(RGD:Mapt)) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(RGD:Mapt, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT, pmod(Ph))) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Proteasome)) causesNoChange deg(a(HBP:"Tau aggregates")) |
| pmid:24027553 | act(p(HGNCGENEFAMILY:Proteasome)) causesNoChange deg(a(HBP:"Tau oligomers")) |
| pmid:24027553 | act(a(MESH:"Proteasome Endopeptidase Complex")) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | p(HGNC:MAPT, pmod(Ub)) positiveCorrelation path(MESH:"Neurofibrillary Tangles") |
| pmid:14612456 | p(HGNC:MAPT, pmod(Ub)) positiveCorrelation p(HGNC:UBE2D2) |
| pmid:14612456 | p(HGNC:MAPT, pmod(Ub)) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:8391280 | p(HGNC:MAPT, pmod(Ub)) increases deg(p(HGNC:MAPT)) |
| pmid:25378699 | p(HGNC:MAPT, pmod(Ub)) positiveCorrelation deg(p(HGNC:MAPT)) |
| pmid:24905733 | p(HGNC:MAPT, pmod(Ub)) negativeCorrelation act(p(HGNC:MAPT)) |
| pmid:24027553 | a(CHEBI:"N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal") increases p(HGNC:MAPT) |
| pmid:24027553 | a(CHEBI:"N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal") decreases act(a(CHEBI:"Hsp90 inhibitor")) |
| pmid:24027553 | act(a(CHEBI:"Hsp90 inhibitor")) decreases p(HGNC:MAPT) |
| pmid:21882945 | a(CHEBI:"Hsp90 inhibitor") increases deg(p(HGNC:MAPT)) |
| pmid:21882945 | a(CHEBI:"Hsp90 inhibitor") increases complex(a(MESH:Proteins), p(FPLX:HSP90)) |
| pmid:24027553 | a(MESH:Autophagosomes) positiveCorrelation a(HBP:"Tau aggregates") |
| pmid:24027553 | path(MESH:"Alzheimer disease, familial, type 3") association p(HGNC:PSEN1) |
| pmid:24027553 | bp(GO:"vacuolar acidification") increases bp(GO:proteolysis) |
| pmid:24027553 | bp(MESH:Autophagy) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24027553 | bp(MESH:Autophagy) increases deg(p(HGNC:MAPT)) |
| pmid:24027553 | bp(MESH:Autophagy) causesNoChange p(HGNC:MAPT) |
| pmid:24027553 | bp(MESH:Autophagy) increases deg(p(HGNC:MAPT, pmod(Ph))) |
| pmid:24027553 | bp(MESH:Autophagy) increases deg(p(HGNC:MAPT, pmod(Ph))) |
| pmid:24027553 | bp(MESH:Autophagy) decreases p(HGNC:MAPT, var("p.P301L")) |
| pmid:24027553 | bp(MESH:Autophagy) decreases a(HBP:"Tau aggregates") |
| pmid:24027553 | bp(MESH:Autophagy) increases deg(a(HBP:"Tau aggregates")) |
| pmid:24027553 | bp(MESH:Autophagy) increases deg(a(HBP:"Tau aggregates")) |
| pmid:24027553 | bp(MESH:Autophagy) increases deg(a(HBP:"Tau aggregates")) |
| pmid:24027553 | bp(MESH:Autophagy) decreases p(MGI:Mapt, var("p.P301S")) |
| pmid:24027553 | bp(MESH:Autophagy) decreases p(MGI:Mapt, pmod(Ph, Thr, 212), var("p.P301S")) |
| pmid:24027553 | bp(MESH:Autophagy) decreases p(MGI:Mapt, pmod(Ph, Ser, 214), var("p.P301S")) |
| pmid:24027553 | bp(MESH:Autophagy) negativeCorrelation bp(GO:"neuron death") |
| pmid:24027553 | bp(MESH:Autophagy) increases deg(p(HBP:"Tau C3")) |
| pmid:24027553 | bp(MESH:Autophagy) decreases p(HBP:"Tau C3") |
| pmid:24027553 | bp(MESH:Autophagy) decreases a(HBP:"Tau epitope, AT8") |
| pmid:24027553 | bp(MESH:Autophagy) decreases a(HBP:"Tau epitope, PHF1") |
| pmid:24027553 | bp(MESH:Autophagy) decreases a(HBP:"Tau epitope, 12E8") |
| pmid:24027553 | bp(MESH:Autophagy) increases deg(a(HBP:"Tau oligomers")) |
| pmid:24027553 | composite(p(HGNC:CTSD), p(HGNC:MAPT)) decreases p(HGNC:MAPT) |
| pmid:24027553 | composite(p(HGNC:CTSD), p(HGNC:MAPT)) decreases deg(p(HGNC:MAPT)) |
| pmid:24027553 | a(MESH:"3-methyladenine") decreases bp(MESH:Autophagy) |
| pmid:24027553 | a(MESH:"3-methyladenine") increases p(HGNC:MAPT, frag("?")) |
| pmid:24027553 | a(MESH:Trehalose) increases bp(MESH:Autophagy) |
| pmid:24027553 | a(MESH:Trehalose) increases bp(MESH:Autophagy) |
| pmid:24027553 | a(MESH:Trehalose) increases bp(MESH:Autophagy) |
| pmid:24027553 | a(MESH:Trehalose) decreases a(HBP:"Tau aggregates") |
| pmid:24027553 | a(MESH:Trehalose) decreases p(HGNC:MAPT) |
| pmid:24027553 | p(MGI:Mapt, pmod(Ph)) increases path(HBP:Neurodegeneration) |
| pmid:30126037 | p(MGI:Mapt, pmod(Ph)) causesNoChange p(MGI:Cdkn2a) |
| pmid:19491104 | p(MGI:Mapt, pmod(Ph)) association p(MGI:Mapk8ip1) |
| pmid:19491104 | p(MGI:Mapt, pmod(Ph)) negativeCorrelation act(p(MGI:Mapk8ip1)) |
| pmid:19491104 | p(MGI:Mapt, pmod(Ph)) negativeCorrelation act(p(MGI:Klc1)) |
| pmid:28173111 | p(MGI:Mapt, pmod(Ph)) positiveCorrelation r(MGI:Dnm1l) |
| pmid:24027553 | composite(a(MESH:Ubiquitin), p(HGNC:MAPT)) increases p(HGNC:MAPT, pmod(Ub)) |
| pmid:24027553 | composite(a(CHEBI:"magnesium(2+)"), a(CHEBI:ATP)) increases act(p(HGNCGENEFAMILY:Proteasome)) |
| pmid:16176937 | p(RGD:Mapt) isA complex(p(RGD:Klc1), p(RGD:Mapt)) |
| pmid:16176937 | p(RGD:Mapt) isA complex(p(RGD:Klc2), p(RGD:Mapt)) |
| pmid:20133804 | act(p(RGD:Mapt)) increases bp(GO:"microtubule polymerization") |
| pmid:20133804 | act(p(RGD:Mapt)) increases bp(GO:"neuron projection development") |
| pmid:27671637 | a(HBP:"Tau epitope, AT8") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27671637 | a(HBP:"Tau epitope, AT8") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) |
| pmid:27671637 | a(HBP:"Tau epitope, PHF1") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27671637 | a(HBP:"Tau epitope, PHF1") association p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) |
| pmid:22764226 | a(HBP:"Tau epitope, PHF1") negativeCorrelation p(MGI:Ppp2ca, pmod(Me)) |
| pmid:22156579 | a(HBP:"Tau epitope, PHF1") positiveCorrelation a(HBP:"Tau epitope, 12E8") |
| pmid:22156579 | a(HBP:"Tau epitope, PHF1") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:22156579 | a(HBP:"Tau epitope, PHF1") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:25125464 | a(HBP:"Tau epitope, PHF1") positiveCorrelation p(MGI:Crhr1) |
| pmid:19459590 | a(HBP:"Tau epitope, PHF1") decreases act(p(HGNC:MAPT)) |
| pmid:25031639 | a(HBP:"Tau epitope, PHF1") positiveCorrelation deg(p(HGNC:MAPT)) |
| pmid:22156579 | a(HBP:"Tau epitope, PHF1") positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:27671637 | a(HBP:"Tau epitope, 12E8") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27671637 | a(HBP:"Tau epitope, 12E8") association p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) |
| pmid:22156579 | a(HBP:"Tau epitope, 12E8") positiveCorrelation a(HBP:"Tau epitope, PHF1") |
| pmid:25031639 | a(HBP:"Tau epitope, 12E8") positiveCorrelation act(p(HGNC:HDAC6)) |
| pmid:25031639 | a(HBP:"Tau epitope, 12E8") partOf p(HBP:"KXGS motif") |
| pmid:25031639 | a(HBP:"Tau epitope, 12E8") negativeCorrelation act(p(HGNC:STUB1)) |
| pmid:27574109 | a(HBP:"Tau oligomers") association a(HBP:pretangles) |
| pmid:27574109 | a(HBP:"Tau oligomers") association a(HBP:"Braak_Stage I") |
| pmid:27574109 | a(HBP:"Tau oligomers") association a(HBP:"Braak_Stage II") |
| pmid:27574109 | a(HBP:"Tau oligomers") association a(MESH:"Neurofibrillary Tangles") |
| pmid:27574109 | a(HBP:"Tau oligomers") association a(HBP:"Corticobasal Degeneration") |
| pmid:27574109 | a(HBP:"Tau oligomers") positiveCorrelation a(HBP:"Corticobasal Degeneration") |
| pmid:27574109 | a(HBP:"Tau oligomers") positiveCorrelation a(HBP:"Corticobasal Degeneration") |
| pmid:27574109 | a(HBP:"Tau oligomers") association a(GO:"Pick body") |
| pmid:27574109 | a(HBP:"Tau oligomers") positiveCorrelation path(MESH:Tauopathies) |
| pmid:29686391 | a(HBP:"Tau oligomers") positiveCorrelation path(MESH:Tauopathies) |
| pmid:28420982 | a(HBP:"Tau oligomers") increases path(MESH:Tauopathies) |
| pmid:28420982 | a(HBP:"Tau oligomers") increases path(MESH:Tauopathies) |
| pmid:27574109 | a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27574109 | a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28420982 | a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27574109 | a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pmid:27574109 | a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pmid:29686391 | a(HBP:"Tau oligomers") positiveCorrelation bp(HBP:neurotoxicity) |
| pmid:22817713 | a(HBP:"Tau oligomers") increases bp(HBP:neurotoxicity) |
| pmid:22817713 | a(HBP:"Tau oligomers") increases bp(HBP:neurotoxicity) |
| pmid:29686391 | a(HBP:"Tau oligomers") positiveCorrelation tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:28420982 | a(HBP:"Tau oligomers") increases path(MESH:Disease) |
| pmid:28420982 | a(HBP:"Tau oligomers") increases bp(HP:Neurodegeneration) |
| pmid:28420982 | a(HBP:"Tau oligomers") increases bp(HP:Neurodegeneration) |
| pmid:22817713 | a(HBP:"Tau oligomers") increases bp(HP:Neurodegeneration) |
| pmid:28420982 | a(HBP:"Tau oligomers") increases path(MESH:"Brain Injuries, Traumatic") |
| pmid:28420982 | a(HBP:"Tau oligomers") decreases a(GO:synapse) |
| pmid:22486774 | a(HBP:"Tau oligomers") partOf a(GO:synapse) |
| pmid:28420982 | a(HBP:"Tau oligomers") increases a(HBP:"granular tau oligomers") |
| pmid:28420982 | a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:28420982 | a(HBP:"Tau oligomers") decreases bp(GO:cognition) |
| pmid:28420982 | a(HBP:"Tau oligomers") decreases bp(GO:"mitochondrion organization") |
| pmid:28420982 | a(HBP:"Tau oligomers") decreases bp(GO:"maintenance of synapse structure") |
| pmid:28420982 | a(HBP:"Tau oligomers") increases tloc(p(HGNC:MAPT), fromLoc(GO:"neuron part"), toLoc(GO:"neuron part")) |
| pmid:28420982 | a(HBP:"Tau oligomers") decreases bp(GO:memory) |
| pmid:28420982 | a(HBP:"Tau oligomers") increases a(HBP:"Tau annular protofibrils") |
| pmid:28420982 | a(HBP:"Tau oligomers") decreases bp(MESH:"Cell Survival") |
| pmid:28420982 | a(HBP:"Tau oligomers") association p(HGNC:PRNP) |
| pmid:28420982 | a(HBP:"Tau oligomers") decreases act(a(GO:microtubule)) |
| pmid:28420982 | a(HBP:"Tau oligomers") decreases a(MESH:"Electron Transport Complex I") |
| pmid:28420982 | a(HBP:"Tau oligomers") decreases act(a(MESH:"Electron Transport Complex I")) |
| pmid:28420982 | a(HBP:"Tau oligomers") decreases bp(GO:"ATP synthesis coupled proton transport") |
| pmid:28420982 | a(HBP:"Tau oligomers") increases act(p(HGNC:CASP9)) |
| pmid:28420982 | a(HBP:"Tau oligomers") increases sec(p(HGNC:CYCS)) |
| pmid:22817713 | a(HBP:"Tau oligomers") increases a(HBP:"Tau aggregates") |
| pmid:22817713 | a(HBP:"Tau oligomers") association p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:22817713 | a(HBP:"Tau oligomers") association p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:22817713 | a(HBP:"Tau oligomers") association p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:26671985 | act(a(HBP:"Tau oligomers")) increases a(HBP:neurotoxicity) |
| pmid:26671985 | act(a(HBP:"Tau oligomers")) decreases act(complex(GO:axon)) |
| pmid:26671985 | act(a(HBP:"Tau oligomers")) positiveCorrelation p(HBP:"phosphatase-activating domain") |
| pmid:27716675 | a(HBP:"Tau oligomers") positiveCorrelation a(HBP:neuroinflammation) |
| pmid:27716675 | a(HBP:"Tau oligomers") increases a(HBP:"Pathological Tau Spreading") |
| pmid:27574109 | a(HBP:"4R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pmid:27574109 | a(HBP:"4R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pmid:27574109 | a(HBP:"4R tau") positiveCorrelation bp(GO:"positive regulation of protein oligomerization") |
| pmid:27574109 | a(HBP:"4R tau") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27574109 | a(HBP:"4R tau") positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pmid:27574109 | a(HBP:"4R tau") positiveCorrelation a(HBP:"Corticobasal Degeneration") |
| pmid:27574109 | a(HBP:"Tau isoform F (441 aa)") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") |
| pmid:27574109 | a(HBP:"Tau isoform F (441 aa)") increases a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"Tau isoform F (441 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:29686391 | a(HBP:"Tau isoform F (441 aa)") positiveCorrelation tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation a(HBP:"Tau isoform F (441 aa)") |
| pmid:29686391 | a(HBP:"Tau isoform F (441 aa)") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) association a(CHEBI:heparin) |
| pmid:29686391 | tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) association a(HBP:"6-O-sulfated heparin") |
| pmid:27574109 | bp(GO:"positive regulation of protein oligomerization") positiveCorrelation a(HBP:"4R tau") |
| pmid:27574109 | bp(GO:"positive regulation of protein oligomerization") positiveCorrelation a(HBP:"3R tau") |
| pmid:27574109 | a(HBP:"Tau isoform Fetal-tau (352 aa)") association a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:"Tau isoform Fetal-tau (352 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:"Tau isoform Fetal-tau (352 aa)") increases a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"Tau isoform Fetal-tau (352 aa)") increases a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") association a(HBP:"Tau isoform Fetal-tau (352 aa)") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform Fetal-tau (352 aa)") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") association a(HBP:"Tau isoform D (383 aa)") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform D (383 aa)") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") association a(HBP:"Tau isoform C (410 aa)") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform C (410 aa)") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform B (381 aa)") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform F (441 aa)") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform E (412 aa)") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") association a(HBP:pretangles) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") association a(HBP:"Braak_Stage I") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") association a(HBP:"Braak_Stage II") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") association a(MESH:"Neurofibrillary Tangles") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") association a(HBP:"Corticobasal Degeneration") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Corticobasal Degeneration") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") association a(GO:"Pick body") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation path(MESH:Tauopathies) |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27574109 | a(HBP:"phosphatase-activating domain") positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pmid:27574109 | a(HBP:"Tau isoform D (383 aa)") association a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:"Tau isoform D (383 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:"Tau isoform D (383 aa)") increases a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"Tau isoform D (383 aa)") increases a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"Tau isoform C (410 aa)") association a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:"Tau isoform C (410 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:"Tau isoform C (410 aa)") increases a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"Tau isoform C (410 aa)") increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"retrograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") |
| pmid:17493042 | p(HBP:"Tau isoform Fetal-tau (352 aa)") partOf a(MESH:Brain) |
| pmid:27574109 | p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") |
| pmid:27574109 | p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") |
| pmid:27574109 | p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") |
| pmid:27574109 | a(HBP:"Tau isoform B (381 aa)") increases a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"Tau isoform B (381 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:"Tau isoform E (412 aa)") increases a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"Tau isoform E (412 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:pretangles) association a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:pretangles) association a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:pretangles) association p(HGNC:MAPT) |
| pmid:23407988 | a(HBP:pretangles) increases complex(GO:"dendritic tree") |
| pmid:18239272 | a(HBP:pretangles) association p(HGNC:TTBK1) |
| pmid:18239272 | a(HBP:pretangles) association p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:18239272 | a(HBP:pretangles) isA a(GO:"neurofibrillary tangle") |
| pmid:27574109 | a(HBP:"Braak_Stage I") association a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"Braak_Stage I") association a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:"Braak_Stage I") association p(HGNC:MAPT) |
| pmid:28176663 | a(HBP:"Braak_Stage I") positiveCorrelation act(p(HGNC:GSK3B), ma(kin)) |
| pmid:27574109 | a(HBP:"Braak_Stage II") association a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"Braak_Stage II") association a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:"Braak_Stage II") association p(HGNC:MAPT) |
| pmid:28176663 | a(HBP:"Braak_Stage II") positiveCorrelation act(p(HGNC:GSK3B), ma(kin)) |
| pmid:27574109 | a(HBP:"Corticobasal Degeneration") association a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:27574109 | a(HBP:"Corticobasal Degeneration") association a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(HBP:"Corticobasal Degeneration") association p(HGNC:MAPT) |
| pmid:27574109 | a(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT) |
| pmid:27574109 | a(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT) |
| pmid:27574109 | a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"4R tau") |
| pmid:27574109 | a(HBP:"Corticobasal Degeneration") positiveCorrelation composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) |
| pmid:27574109 | a(GO:"Pick body") association a(HBP:"Tau oligomers") |
| pmid:27574109 | a(GO:"Pick body") association a(HBP:"phosphatase-activating domain") |
| pmid:27574109 | a(GO:"Pick body") association p(HGNC:MAPT) |
| pmid:27574109 | composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27574109 | composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pmid:27574109 | composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation a(HBP:"Corticobasal Degeneration") |
| pmid:17403556 | a(HBP:"amyloid-beta derived diffusible ligands") decreases bp(MESH:"Cell Survival") |
| pmid:17403556 | a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:17403556 | a(HBP:"amyloid-beta derived diffusible ligands") increases p(RGD:Mapt, pmod(Ph)) |
| pmid:17403556 | a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17403556 | a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17403556 | a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17403556 | a(HBP:"amyloid-beta derived diffusible ligands") increases complex(a(GO:synapse), a(HBP:"amyloid-beta derived diffusible ligands")) |
| pmid:17403556 | a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:17403556 | a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:17403556 | a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:18096814 | a(HBP:"amyloid-beta derived diffusible ligands") increases tloc(p(MGI:Fyn), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) |
| pmid:18096814 | a(HBP:"amyloid-beta derived diffusible ligands") increases tloc(p(MGI:Mapt), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) |
| pmid:20133804 | p(RGD:Mapt, pmod(Ph)) positiveCorrelation p(RGD:Fkbp4) |
| pmid:17403556 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22253473 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:10391244 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) association p(HGNC:PIN1, frag("5_39")) |
| pmid:10391244 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) negativeCorrelation act(p(HGNC:MAPT)) |
| pmid:21367866 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation p(HGNC:CDC37) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation p(FPLX:PKA) |
| pmid:23948915 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) negativeCorrelation bp(GO:"apoptotic process") |
| pmid:26118667 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) negativeCorrelation m(MIRBASE:"rno-mir-195") |
| pmid:22833681 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) equivalentTo a(HBP:"Tau epitope, AT180") |
| pmid:19623258 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) equivalentTo p(HBP:"Tau epitope, AT180") |
| pmid:22926167 | p(HGNC:MAPT, pmod(Ph, Thr, 231)) increases a(HBP:"Tau aggregates") |
| pmid:17403556 | a(HBP:"amyloid-beta antibody, NU1") decreases act(a(HBP:"amyloid-beta derived diffusible ligands")) |
| pmid:17403556 | a(HBP:"amyloid-beta antibody, NU1") decreases complex(a(HBP:"amyloid-beta derived diffusible ligands"), a(MESH:Neurons)) |
| pmid:17403556 | a(HBP:"amyloid-beta antibody, NU1") decreases complex(a(HBP:"amyloid-beta derived diffusible ligands"), a(MESH:Neurons)) |
| pmid:17403556 | a(HBP:"amyloid-beta antibody, NU1") decreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17403556 | a(HBP:"amyloid-beta antibody, NU1") decreases complex(a(GO:synapse), a(HBP:"amyloid-beta derived diffusible ligands")) |
| pmid:28420982 | p(HGNC:MAPT, pmod(Ph, Thr, 181)) association a(MESH:Exosomes) |
| pmid:28420982 | p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28420982 | p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation p(FPLX:PKA) |
| pmid:11943212 | p(HGNC:MAPT, pmod(Ph, Thr, 181)) partOf p(HBP:"Tau epitope, AT270") |
| pmid:28176663 | p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation a(CHEBI:"D-ribose") |
| pmid:17403556 | a(MESH:"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine") decreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17403556 | a(MESH:"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine") decreases bp(GO:"signal transduction") |
| pmid:17403556 | a(MESH:"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:17403556 | a(CHEBI:LY294002) decreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:17403556 | a(CHEBI:LY294002) decreases bp(GO:"signal transduction") |
| pmid:17403556 | a(CHEBI:LY294002) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:17403556 | complex(a(HBP:"amyloid-beta derived diffusible ligands"), p(HGNC:MAPT)) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) association a(GO:"somatodendritic compartment") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases bp(GO:"protein localization to somatodendritic compartment") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) association a(HBP:"Tau epitope, 12E8") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) association a(HBP:"Tau epitope, PHF1") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) negativeCorrelation a(HBP:"Tau epitope, AT180") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) positiveCorrelation a(HBP:"Tau epitope, AT8") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange a(GO:"neurofibrillary tangle") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange a(GO:"dendritic spine") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases a(GO:mitochondrion) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange act(a(GO:presynapse)) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases a(MESH:Axons) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Hippocampus) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Hippocampus) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Hippocampus) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases bp(GO:neurogenesis) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) negativeCorrelation act(a(MESH:Microglia)) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases a(MESH:Microglia) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange act(a(MESH:Microglia)) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange path(MESH:Inflammation) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Mapt) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Mapt) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases tloc(p(MGI:Mapt), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Mapt) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:"Stem Cells") |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases bp(GO:"neuron differentiation") |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases p(MGI:Wnt5a) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Wnt3) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Wnt3) |
| pmid:27671637 | a(GO:"somatodendritic compartment") association p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) |
| pmid:27671637 | a(GO:"somatodendritic compartment") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(GO:"somatodendritic compartment") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases bp(GO:"protein localization to somatodendritic compartment") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(HP:"Argyrophilic inclusion bodies") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(HP:"Argyrophilic inclusion bodies") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(MESH:Axons) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Axons) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation a(GO:"dendritic spine") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:"dendritic spine") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases act(a(GO:dendrite)) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(HBP:"Tau epitope, 12E8") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(HBP:"Tau epitope, PHF1") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation a(HBP:"Tau epitope, AT180") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(HBP:"Tau epitope, AT8") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:"mitochondrial transport") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:mitochondrion) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(CHEBI:ATP) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(CHEBI:ATP) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation act(a(MESH:Neurons)) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Fos) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation bp(GO:"astrocyte activation") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Gfap) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation bp(GO:"response to oxidative stress") |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Hmox1) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases act(a(GO:presynapse)) |
| pmid:27671637 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:"spontaneous synaptic transmission") |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(HBP:"Tau aggregates") |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:synapse) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases path(HBP:Neurodegeneration) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation act(a(MESH:Microglia)) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(MESH:Microglia) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation act(a(MESH:Microglia)) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases path(MESH:Inflammation) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases path(MESH:Hypertrophy) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases tloc(p(MGI:Mapt), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange p(MGI:Mapt) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases tloc(p(MGI:Mapt), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange a(MESH:"Stem Cells") |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases bp(GO:"neuron differentiation") |
| pmid:29202785 | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Hippocampus) |
| pmid:27671637 | a(HP:"Argyrophilic inclusion bodies") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27671637 | a(HP:"Argyrophilic inclusion bodies") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27671637 | a(HP:"Argyrophilic inclusion bodies") causesNoChange p(MGI:Syp) |
| pmid:27671637 | a(MESH:Axons) positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27671637 | a(GO:"dendritic spine") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27807169 | a(GO:"dendritic spine") positiveCorrelation p(RGD:Cdk5r2) |
| pmid:22156579 | a(GO:"dendritic spine") negativeCorrelation p(HGNC:MARK4) |
| pmid:27671637 | p(MGI:Mapt, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) decreases complex(a(GO:microtubule), p(MGI:Mapt)) |
| pmid:27671637 | a(HBP:"Tau epitope, AT180") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27671637 | a(HBP:"Tau epitope, AT180") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) |
| pmid:22833681 | a(HBP:"Tau epitope, AT180") equivalentTo p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:27671637 | composite(a(HP:"Argyrophilic inclusion bodies"), p(MGI:Mapt)) negativeCorrelation bp(GO:"cellular protein catabolic process") |
| pmid:27671637 | a(GO:mitochondrion) positiveCorrelation a(CHEBI:ATP) |
| pmid:25987199 | act(a(GO:mitochondrion)) positiveCorrelation act(p(MGI:Ppargc1a)) |
| pmid:22952452 | act(a(GO:mitochondrion)) positiveCorrelation p(HGNC:TRAK1) |
| pmid:22952452 | act(a(GO:mitochondrion)) positiveCorrelation p(HGNC:RHOT1) |
| pmid:27671637 | p(MGI:Fos) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27671637 | p(MGI:Fos) biomarkerFor act(a(MESH:Neurons)) |
| pmid:27671637 | p(MGI:Gfap) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27671637 | p(MGI:Gfap) biomarkerFor bp(GO:"astrocyte activation") |
| pmid:27671637 | p(MGI:Hmox1) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| pmid:27671637 | p(MGI:Hmox1) biomarkerFor bp(GO:"response to oxidative stress") |
| pmid:27671637 | a(CHEBI:adenosine) increases act(p(MGI:Adora1)) |
| pmid:27671637 | a(CHEBI:adenosine) decreases act(a(MESH:Neurons)) |
| pmid:27671637 | a(CHEBI:adenosine) decreases act(a(GO:presynapse)) |
| pmid:27671637 | a(CHEBI:adenosine) decreases bp(GO:"long-term synaptic potentiation") |
| pmid:21882945 | a(CHEBI:adenosine) decreases act(p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:27671637 | act(p(MGI:Adora1)) decreases act(a(MESH:Neurons)) |
| pmid:27671637 | act(p(MGI:Adora1)) decreases act(a(GO:presynapse)) |
| pmid:27671637 | act(p(MGI:Adora1)) decreases bp(GO:"long-term synaptic potentiation") |
| pmid:27671637 | a(PUBCHEM:64627) decreases act(p(MGI:Adora1)) |
| pmid:27671637 | a(PUBCHEM:64627) increases act(a(MESH:Neurons)) |
| pmid:27671637 | a(PUBCHEM:64627) increases act(a(GO:presynapse)) |
| pmid:27671637 | a(PUBCHEM:64627) increases a(GO:"dendritic spine") |
| pmid:27671637 | a(PUBCHEM:64627) decreases a(MESH:Axons) |
| pmid:27671637 | a(MESH:"BSc 3094") decreases a(HBP:"Tau aggregates") |
| pmid:27671637 | a(MESH:"BSc 3094") increases act(a(GO:presynapse)) |
| pmid:27671637 | composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases a(GO:"dendritic spine") |
| pmid:27671637 | composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases a(GO:"dendritic spine") |
| pmid:27671637 | composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases act(a(GO:presynapse)) |
| pmid:27671637 | composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases act(a(MESH:Neurons)) |
| pmid:27671637 | composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases p(MGI:Fos) |
| pmid:27671637 | composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases path(MESH:"Spatial Memory") |
| pmid:27671637 | composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"long-term memory") |
| pmid:27671637 | composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"associative learning") |
| pmid:27671637 | composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"excitatory postsynaptic potential") |
| pmid:27671637 | composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"spontaneous synaptic transmission") |
| pmid:27671637 | composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del"))) causesNoChange a(GO:"dendritic spine") |
| pmid:28784767 | p(HGNC:MAPT, pmod(Ph, Ser, 208)) partOf p(HBP:"Tau epitope, AT8") |
| pmid:28784767 | p(HGNC:MAPT, pmod(Ph, Ser, 208)) decreases a(HBP:"Tau Protein Secondary Structure, Turn") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 208)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28784767 | p(HBP:"Tau epitope, AT8") equivalentTo p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205), pmod(Ph, Thr, 208)) |
| pmid:28784767 | p(HBP:"Tau epitope, AT8") increases a(HBP:"Tau aggregates") |
| pmid:18239272 | p(HBP:"Tau epitope, AT8") association a(GO:"neurofibrillary tangle") |
| pmid:18239272 | p(HBP:"Tau epitope, AT8") association a(MESH:"Neuropil Threads") |
| pmid:18239272 | p(HBP:"Tau epitope, AT8") association path(MESH:"Plaque, Amyloid") |
| pmid:28784767 | p(HBP:"Tau epitope, AT8") increases bp(HBP:"Tau aggregates") |
| pmid:27087442 | p(HBP:"Tau epitope, AT8") positiveCorrelation p(HBP:"CDK5R1 p25") |
| pmid:25125464 | p(HBP:"Tau epitope, AT8") positiveCorrelation p(MGI:Crhr1) |
| pmid:19459590 | p(HBP:"Tau epitope, AT8") negativeCorrelation act(p(HGNC:MAPT)) |
| pmid:19459590 | p(HBP:"Tau epitope, AT8") decreases act(p(HGNC:MAPT)) |
| pmid:22833681 | p(HBP:"Tau epitope, AT8") increases complex(p(HGNC:FYN), p(MGI:Mapt)) |
| pmid:22253473 | p(HBP:"Tau epitope, AT8") positiveCorrelation a(MESH:Neuropil) |
| pmid:20869593 | p(HBP:"Tau epitope, AT8") positiveCorrelation p(HGNC:MAPT, pmod(Ac)) |
| pmid:20869593 | p(HBP:"Tau epitope, AT8") negativeCorrelation act(p(HGNC:SIRT1)) |
| pmid:19623258 | p(HBP:"Tau epitope, AT8") positiveCorrelation act(complex(GO:"NMDA selective glutamate receptor complex")) |
| pmid:28784767 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf p(HBP:"Tau epitope, AT8") |
| pmid:18239272 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf p(HBP:"Tau epitope, AT8") |
| pmid:24760868 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) increases p(HGNC:MAPT, loc(MESH:"Dendritic Spines")) |
| pmid:22817713 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) association a(HBP:"Tau aggregates") |
| pmid:22817713 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) association a(HBP:"Tau oligomers") |
| pmid:22486774 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf a(HBP:"Tau oligomers") |
| pmid:14612456 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) isA p(HGNC:MAPT, pmod(Ph)) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(FPLX:PKA) |
| pmid:26118667 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) negativeCorrelation m(MIRBASE:"rno-mir-195") |
| pmid:22833681 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) |
| pmid:24406748 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) |
| pmid:23294633 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pmid:22253473 | p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf a(GO:"neurofibrillary tangle") |
| pmid:28784767 | p(HGNC:MAPT, var("pGly207Val")) increases a(HBP:"Tau aggregates") |
| pmid:28784767 | p(HGNC:MAPT, var("pGly207Val")) increases bp(HBP:"Tau aggregates") |
| pmid:28784767 | p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) increases a(HBP:"Tau Protein Secondary Structure, Turn") |
| pmid:21882945 | p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28784767 | a(HBP:"Tau Protein Secondary Structure, Turn") decreases a(HBP:"Tau aggregates") |
| pmid:28784767 | a(HBP:"Tau Protein Secondary Structure, Turn") decreases a(HBP:"Tau aggregates") |
| pmid:28784767 | a(HBP:"Tau Protein Secondary Structure, Turn") decreases bp(HBP:"Tau aggregates") |
| pmid:28784767 | a(HBP:"Tau Protein Secondary Structure, Turn") decreases bp(HBP:"Tau aggregates") |
| pmid:28784767 | p(HGNC:MAPT, var("p.Gly207Val")) decreases a(HBP:"Tau Protein Secondary Structure, Turn") |
| pmid:28784767 | act(p(FPLX:CSNK1), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 208)) |
| pmid:25673844 | p(FPLX:CSNK1) isA p(HBP:"CK1 superfamily") |
| pmid:25673844 | p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 42)) |
| pmid:25673844 | p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 45)) |
| pmid:25673844 | p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 47)) |
| pmid:25673844 | p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 80)) |
| pmid:25673844 | p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 81)) |
| pmid:25673844 | p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Thr, 84)) |
| pmid:28784767 | p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205), pmod(Ph, Thr, 208)) equivalentTo p(HBP:"Tau epitope, AT8") |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases path(MESH:"Frontotemporal Dementia") |
| pmid:24406748 | p(HGNC:MAPT, var("p.Pro301Ser")) increases path(MESH:"Frontotemporal Dementia") |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:"early endosome") |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:"late endosome") |
| pmid:29590627 | p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:lysosome) |
| pmid:24406748 | p(HGNC:MAPT, var("p.Pro301Ser")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:24406748 | p(HGNC:MAPT, var("p.Pro301Ser")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:24406748 | p(HGNC:MAPT, var("p.Pro301Ser")) decreases bp(GO:"axonal transport") |
| pmid:24406748 | p(HGNC:MAPT, var("p.Pro301Ser")) decreases path(MESH:Cognition) |
| pmid:29590627 | a(CHEBI:dextran) increases tloc(a(CHEBI:dextran)) |
| pmid:28420982 | a(CHEBI:dextran) association a(HBP:"Tau aggregates") |
| pmid:29590627 | a(CHEBI:heparin) causesNoChange tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | a(CHEBI:heparin) causesNoChange tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29686391 | a(CHEBI:heparin) association tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | a(CHEBI:heparin) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:26751493 | a(CHEBI:heparin) association p(HBP:"Tau aggregates") |
| pmid:27601475 | a(CHEBI:heparin) increases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(CHEBI:heparin) partOf complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) |
| pmid:29590627 | a(GO:"early endosome") association p(HGNC:MAPT, var("p.Pro301Ser")) |
| pmid:29590627 | a(GO:"early endosome") association a(HBP:"Tau aggregates") |
| pmid:29590627 | a(CHEBI:dynasore) decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | a(CHEBI:dynasore) decreases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | a(CHEBI:dynasore) decreases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29686391 | a(CHEBI:dynasore) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29590627 | a(CHEBI:"cytochalasin D") decreases bp(GO:"actin filament polymerization") |
| pmid:29590627 | a(CHEBI:"cytochalasin D") negativeCorrelation bp(GO:"bulk synaptic vesicle endocytosis") |
| pmid:29590627 | a(CHEBI:"cytochalasin D") negativeCorrelation bp(GO:macropinocytosis) |
| pmid:29590627 | a(CHEBI:"cytochalasin D") decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | a(CHEBI:"cytochalasin D") causesNoChange tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | a(CHEBI:"cytochalasin D") causesNoChange tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | bp(GO:"actin filament polymerization") positiveCorrelation bp(GO:"bulk synaptic vesicle endocytosis") |
| pmid:29590627 | bp(GO:"actin filament polymerization") positiveCorrelation bp(GO:macropinocytosis) |
| pmid:29590627 | bp(GO:"actin filament polymerization") increases tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:24760868 | bp(GO:"actin filament polymerization") increases complex(GO:"filamentous actin") |
| pmid:27041503 | bp(GO:"actin filament polymerization") negativeCorrelation bp(MESH:"Long-Term Potentiation") |
| pmid:29590627 | bp(GO:"bulk synaptic vesicle endocytosis") negativeCorrelation a(CHEBI:"cytochalasin D") |
| pmid:29590627 | bp(GO:"bulk synaptic vesicle endocytosis") positiveCorrelation bp(GO:"actin filament polymerization") |
| pmid:29590627 | bp(GO:macropinocytosis) negativeCorrelation a(CHEBI:"cytochalasin D") |
| pmid:29590627 | bp(GO:macropinocytosis) positiveCorrelation bp(GO:"actin filament polymerization") |
| pmid:26751493 | bp(GO:macropinocytosis) positiveCorrelation complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) |
| pmid:26751493 | bp(GO:macropinocytosis) isA tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) |
| pmid:29590627 | composite(a(CHEBI:dynasore), p(HGNC:MAPT, var("p.Pro301Ser"))) causesNoChange tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:29590627 | composite(a(CHEBI:"cytochalasin D"), p(HGNC:MAPT, var("p.Pro301Ser"))) decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) |
| pmid:24760868 | p(HGNC:DLG4, loc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pmid:26751493 | p(HGNC:DLG4) association p(HBP:"projection domain") |
| pmid:26751493 | p(HGNC:DLG4) association a(HBP:"projection domain") |
| pmid:24760868 | p(MESH:Actins, loc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pmid:24760868 | p(MESH:Actins) positiveCorrelation bp(GO:"long-term synaptic potentiation") |
| pmid:24760868 | complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) association bp(GO:"long-term synaptic potentiation") |
| pmid:17187063 | complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) positiveCorrelation a(HBP:Neurodegeneration) |
| pmid:24760868 | a(MESH:jasplakinolide) increases bp(GO:"actin filament polymerization") |
| pmid:24760868 | a(MESH:jasplakinolide) increases bp(GO:"actin filament polymerization") |
| pmid:24760868 | a(MESH:jasplakinolide) increases p(HGNC:MAPT) |
| pmid:24760868 | a(MESH:jasplakinolide) increases p(HGNC:GRIA1) |
| pmid:24760868 | a(MESH:jasplakinolide) decreases p(HGNC:FYN) |
| pmid:24760868 | a(CHEBI:"latrunculin A") increases bp(GO:"actin filament depolymerization") |
| pmid:24760868 | a(CHEBI:"latrunculin A") increases bp(GO:"actin filament depolymerization") |
| pmid:24760868 | a(CHEBI:"latrunculin A") decreases p(HGNC:MAPT) |
| pmid:24760868 | complex(a(MESH:"Dendritic Spines"), p(HGNC:MAPT)) association a(MESH:"Dendritic Spines") |
| pmid:29202785 | a(CHEBI:doxycycline) decreases p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) |
| pmid:29202785 | a(CHEBI:doxycycline) decreases p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) |
| pmid:29202785 | a(CHEBI:doxycycline) decreases p(MGI:Wnt5a) |
| pmid:29202785 | a(CHEBI:doxycycline) decreases p(MGI:Wnt3) |
| pmid:21734277 | p(HBP:"6D tau") decreases bp(GO:"anterograde axonal protein transport") |
| pmid:21734277 | p(HBP:"6D tau") decreases bp(GO:"anterograde axonal protein transport") |
| pmid:21734277 | p(HBP:"6D tau") causesNoChange bp(GO:"retrograde axonal protein transport") |
| pmid:21734277 | p(HBP:"6D tau") increases act(p(MESH:"Protein Phosphatase 1")) |
| pmid:21734277 | p(HBP:"6D tau") increases act(p(MESH:"Glycogen Synthase Kinase 3")) |
| pmid:21734277 | act(p(HBP:"6D tau")) association p(HBP:"6D tau", frag("2_18")) |
| pmid:21734277 | p(HBP:"6P tau") decreases bp(GO:"anterograde axonal protein transport") |
| pmid:21734277 | p(HBP:"6P tau") causesNoChange bp(GO:"retrograde axonal protein transport") |
| pmid:21734277 | act(p(MESH:"Protein Phosphatase 1")) decreases bp(GO:"anterograde axonal protein transport") |
| pmid:21734277 | act(p(MESH:"Glycogen Synthase Kinase 3")) decreases bp(GO:"anterograde axonal protein transport") |
| pmid:21734277 | p(HBP:"6D tau", frag("2_18")) association act(p(HBP:"6D tau")) |
| pmid:21734277 | p(HBP:"6D tau", frag("2_18")) association bp(GO:"anterograde axonal protein transport") |
| pmid:21734277 | p(HBP:"6D tau", frag("2_18")) increases bp(GO:"anterograde axonal protein transport") |
| pmid:21734277 | p(HBP:"6D tau", frag("2_18")) increases bp(GO:"anterograde axonal protein transport") |
| pmid:21734277 | p(HBP:"6D tau", frag("2_18")) causesNoChange bp(GO:"retrograde axonal protein transport") |
| pmid:21734277 | p(HBP:"6D tau", frag("2_18")) decreases p(HBP:"endogenous axoplasmic phosphatases") |
| pmid:21734277 | p(HBP:"6D tau", frag("2_18")) decreases act(p(MESH:"Glycogen Synthase Kinase 3")) |
| pmid:21734277 | p(HBP:"6D tau", frag("2_18")) decreases act(p(MESH:"Glycogen Synthase Kinase 3")) |
| pmid:21734277 | p(HBP:"6D tau", frag("2_18")) association p(HBP:TNT1) |
| pmid:21734277 | act(p(HBP:"6D tau", frag("2_18"))) association path(MESH:"Alzheimer Disease") |
| pmid:21734277 | act(p(HBP:"6D tau", frag("2_18"))) association path(MESH:"Alzheimer Disease") |
| pmid:21734277 | a(HBP:"I-2") increases act(p(HBP:"6D tau", frag("2_18"))) |
| pmid:21734277 | a(HBP:"ING-135") increases act(p(HBP:"6D tau", frag("2_18"))) |
| pmid:21734277 | p(HBP:"AT8 tau") decreases bp(GO:"anterograde axonal protein transport") |
| pmid:21734277 | p(HBP:"AT8 tau") causesNoChange bp(GO:"retrograde axonal protein transport") |
| pmid:21734277 | p(HBP:"AT8 tau") causesNoChange act(p(HBP:"6D tau", frag("2_18"))) |
| pmid:21734277 | p(HBP:"AT8 tau", pmod(Ph)) association p(HGNC:MAPT, pmod(Ph)) |
| pmid:21734277 | p(HBP:"AT8 tau", pmod(Ph)) association path(MESH:Tauopathies) |
| pmid:21734277 | p(HBP:"delta 144-273 tau") decreases bp(GO:"anterograde axonal protein transport") |
| pmid:21734277 | p(HBP:"delta 144-273 tau") causesNoChange bp(GO:"retrograde axonal protein transport") |
| pmid:21734277 | p(HBP:TNT1) association p(HBP:"6D tau", frag("2_18")) |
| pmid:23528736 | p(HGNC:UBB) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23528736 | p(HGNC:UBC) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23528736 | p(HGNC:UBA52) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23528736 | p(HGNC:RPS27A) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23528736 | p(HBP:"UBB+1") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23528736 | p(HBP:"UBB+1") association a(MESH:"Neurofibrillary Tangles") |
| pmid:23528736 | p(HBP:"UBB+1") decreases bp(GO:"protein deubiquitination") |
| pmid:23528736 | p(HBP:"UBB+1") decreases act(p(FPLX:Proteasome)) |
| pmid:23528736 | p(HBP:"UBB+1") increases bp(HP:Neurodegeneration) |
| pmid:23528736 | p(HBP:"UBB+1") increases bp(MESH:"Stress, Physiological") |
| pmid:23528736 | p(HBP:"UBB+1") increases act(p(HGNC:TP53)) |
| pmid:23528736 | p(HGNCGENEFAMILY:"Ubiquitin like modifier activating enzymes") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23528736 | p(HGNCGENEFAMILY:"Ubiquitin conjugating enzymes E2") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23528736 | p(HGNC:RNF182) association path(MESH:"Neurodegenerative Diseases") |
| pmid:23528736 | composite(p(HGNC:HSPA8), p(HGNC:STUB1), p(HGNC:UBE2D2)) increases deg(p(HGNC:MAPT)) |
| pmid:14612456 | p(HGNC:UBE2D2) positiveCorrelation p(HGNC:MAPT, pmod(Ub)) |
| pmid:14612456 | p(HGNC:UBE2D2) isA complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) |
| pmid:23528736 | p(HGNC:BCL2L11) decreases bp(GO:autophagy) |
| pmid:23528736 | a(HP:"Neurofibrillary tangles") decreases act(p(FPLX:Proteasome)) |
| pmid:23528736 | a(CHEBI:"lithium atom") increases bp(GO:autophagy) |
| pmid:23528736 | a(CHEBI:"lithium atom") decreases p(HGNC:MAPT) |
| pmid:23528736 | a(CHEBI:"lithium atom") decreases a(HP:"Neurofibrillary tangles") |
| pmid:30108137 | r(HGNC:TFEB) positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pmid:30108137 | p(MGI:Tfeb) increases p(MGI:Lamp1) |
| pmid:30108137 | p(MGI:Tfeb) increases p(MGI:Ctsa) |
| pmid:30108137 | p(MGI:Tfeb) increases p(MGI:Ctsb) |
| pmid:30108137 | p(MGI:Tfeb) regulates act(a(MESH:Lysosomes)) |
| pmid:30108137 | p(MGI:Tfeb) increases act(a(MESH:Phagocytes)) |
| pmid:30108137 | p(MGI:Tfeb) increases a(HBP:"Tau fibrils") |
| pmid:30108137 | p(MGI:Tfeb) increases a(HBP:"Tau fibrils") |
| pmid:30108137 | p(MGI:Tfeb) increases a(HBP:"Tau fibrils") |
| pmid:30108137 | p(MGI:Tfeb) increases tloc(a(HBP:"Tau fibrils")) |
| pmid:30108137 | p(MGI:Tfeb) increases bp(MESH:Phagocytosis) |
| pmid:30108137 | p(MGI:Tfeb) increases r(MGI:Lamp1) |
| pmid:30108137 | p(MGI:Tfeb) increases bp(MESH:Proteolysis) |
| pmid:30108137 | p(MGI:Tfeb) causesNoChange p(MGI:Phf1) |
| pmid:30108137 | p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(Ph)) |
| pmid:30108137 | p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(Ph)) |
| pmid:30108137 | p(MGI:Tfeb) causesNoChange p(MGI:Mapt, pmod(Ph)) |
| pmid:30108137 | p(MGI:Tfeb) decreases p(MGI:Mapt) |
| pmid:30108137 | p(MGI:Tfeb) decreases path(MESH:Tauopathies) |
| pmid:30108137 | p(MGI:Tfeb) decreases path(MESH:Gliosis) |
| pmid:30108137 | bp(MESH:Pinocytosis) increases act(a(MESH:Astrocytes)) |
| pmid:21882945 | p(HGNC:PPP2R5B) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:21882945 | a(PUBCHEM:134222899) positiveCorrelation bp(GO:cognition) |
| pmid:21882945 | a(CHEBI:rhodanine) decreases a(HBP:"Tau aggregates") |
| pmid:26751493 | a(CHEBI:rhodanine) decreases p(HBP:"Tau aggregates") |
| pmid:21882945 | a(HBP:"Phenylthiazolyl-hydrazide") decreases a(HBP:"Tau aggregates") |
| pmid:21882945 | a(PUBCHEM:53789478) decreases a(HBP:"Tau aggregates") |
| pmid:21882945 | a(CHEBI:anthraquinone) decreases a(HBP:"Tau aggregates") |
| pmid:21882945 | a(CHEBI:benzothiazoles) decreases a(HBP:"Tau aggregates") |
| pmid:21882945 | a(CHEBI:phenothiazines) decreases a(HBP:"Tau aggregates") |
| pmid:21882945 | a(CHEBI:polyphenol) decreases a(HBP:"Tau aggregates") |
| pmid:21882945 | a(CHEBI:polyphenol) decreases complex(p(INTERPRO:"Chaperone J-domain superfamily"), p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:21882945 | a(MESH:"Heat-Shock Proteins") increases bp(GO:"proteasomal protein catabolic process") |
| pmid:21882945 | a(MESH:"Heat-Shock Proteins") increases bp(GO:autophagy) |
| pmid:21882945 | p(INTERPRO:"Chaperone J-domain superfamily") increases act(p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:21882945 | p(INTERPRO:"Chaperone J-domain superfamily") increases rxn(reactants(a(CHEBI:ATP)), products(a(CHEBI:"phosphate(3-)"), a(CHEBI:ADP))) |
| pmid:21882945 | a(MESH:"Guanine Nucleotide Exchange Factors") increases act(p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:21882945 | a(MESH:"Guanine Nucleotide Exchange Factors") increases a(CHEBI:ADP) |
| pmid:21882945 | a(PUBCHEM:25195348) decreases act(a(MESH:"Adenosine Triphosphatases")) |
| pmid:21882945 | a(PUBCHEM:1056) decreases act(p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:21882945 | a(PUBCHEM:1056) regulates complex(p(INTERPRO:"Chaperone J-domain superfamily"), p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:21882945 | a(CHEBI:polyamine) decreases act(p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:21882945 | a(PUBCHEM:6444403) decreases act(p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:21882945 | complex(p(FPLX:HSP90), p(FPLX:HSP90)) increases act(p(FPLX:HSP90)) |
| pmid:21882945 | p(INTERPRO:"Tetratricopeptide repeat-containing domain") regulates act(p(FPLX:HSP90)) |
| pmid:21882945 | a(PUBCHEM:9549213) directlyIncreases complex(a(PUBCHEM:9549213), p(INTERPRO:"Heat shock protein Hsp90, N-terminal")) |
| pmid:21882945 | a(PUBCHEM:9549213) directlyDecreases act(p(FPLX:HSP90)) |
| pmid:21882945 | a(CHEBI:novobiocin) directlyIncreases complex(a(CHEBI:novobiocin), p(INTERPRO:"HSP90, C-terminal domain")) |
| pmid:21882945 | a(CHEBI:novobiocin) directlyDecreases act(p(FPLX:HSP90)) |
| pmid:21882945 | a(PUBCHEM:501026) directlyIncreases complex(a(PUBCHEM:501026), p(INTERPRO:"HSP90, C-terminal domain")) |
| pmid:21882945 | a(PUBCHEM:501026) directlyDecreases act(p(FPLX:HSP90)) |
| pmid:21882945 | a(CHEBI:celastrol) association act(p(FPLX:HSP90)) |
| pmid:29311797 | a(CHEBI:celastrol) decreases act(p(FPLX:HSP90)) |
| pmid:29311797 | a(CHEBI:celastrol) decreases p(HGNC:MAPT) |
| pmid:21882945 | bp(GO:phosphorylation) regulates a(HBP:"Hsp27 oligomers") |
| pmid:21882945 | p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21882945 | p(HGNC:AKT1) association complex(p(FPLX:HSP90), p(HGNC:STUB1)) |
| pmid:21882945 | p(HGNC:AKT1) negativeCorrelation deg(p(HGNC:MAPT)) |
| pmid:21367866 | act(p(HGNC:AKT1), ma(kin)) positiveCorrelation complex(p(HGNC:CDC37), p(SFAM:"HSP90 Family")) |
| pmid:21882945 | complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) |
| pmid:21882945 | complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) increases deg(p(HGNC:MAPT, pmod(Ph))) |
| pmid:14963027 | complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) increases deg(p(HGNC:MAPT, pmod(Ph))) |
| pmid:14963027 | complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) increases rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) |
| pmid:21882945 | complex(p(HGNC:BAG1), p(INTERPRO:"Heat shock protein 70 family")) increases p(HGNC:MAPT) |
| pmid:20071522 | complex(p(HGNC:FKBP5), p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:20071522 | complex(p(HGNC:FKBP5), p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:20071522 | complex(p(HGNC:FKBP5), p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:21882945 | complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases complex(a(MESH:"Protein Phosphatase 2"), p(HGNC:MAPT)) |
| pmid:21882945 | complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) |
| pmid:29311797 | complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases a(HBP:"Tau aggregates") |
| pmid:21882945 | complex(a(MESH:"Protein Phosphatase 2"), p(HGNC:MAPT)) increases complex(a(GO:microtubule), p(HGNC:MAPT)) |
| pmid:21882945 | complex(a(MESH:Proteins), p(INTERPRO:"Heat shock protein 70 family")) positiveCorrelation complex(a(MESH:Proteins), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:21882945 | complex(a(MESH:Proteins), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) positiveCorrelation complex(a(MESH:Proteins), p(INTERPRO:"Heat shock protein 70 family")) |
| pmid:21882945 | complex(a(MESH:Proteins), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) increases bp(GO:"protein polyubiquitination") |
| pmid:21882945 | complex(a(MESH:Proteins), p(FPLX:HSP90)) increases deg(a(MESH:Proteins)) |
| pmid:21882945 | complex(p(HGNC:VHL), p(INTERPRO:"Heat shock protein 70 family")) increases deg(p(HGNC:VHL)) |
| pmid:21882945 | complex(p(FPLX:HSP90), p(HGNC:VHL)) increases deg(p(HGNC:VHL)) |
| pmid:21882945 | complex(p(HGNC:STIP1), p(HGNC:VHL)) increases deg(p(HGNC:VHL)) |
| pmid:30126037 | path(MESH:"Brain Injuries, Traumatic") association p(HGNC:MAPT) |
| pmid:29626319 | path(MESH:"Brain Injuries, Traumatic") increases p(HGNC:MAPT) |
| pmid:26195256 | path(MESH:"Brain Injuries, Traumatic") association p(HBP:"tau aggregates") |
| pmid:29626319 | path(MESH:"Brain Injuries, Traumatic") decreases p(HGNC:AQP4) |
| pmid:29626319 | path(MESH:"Brain Injuries, Traumatic") decreases act(p(HGNC:AQP4)) |
| pmid:29626319 | path(MESH:"Brain Injuries, Traumatic") decreases p(HGNC:AQP4) |
| pmid:29626319 | path(MESH:"Brain Injuries, Traumatic") decreases a(HP:"glymphatic system") |
| pmid:29626319 | path(MESH:"Brain Injuries, Traumatic") decreases a(HP:"glymphatic system") |
| pmid:24561250 | path(MESH:"Brain Injuries, Traumatic") increases bp(GO:"cell death") |
| pmid:30126037 | bp(GO:"cellular senescence") association bp(GO:"cell cycle") |
| pmid:30126037 | bp(GO:"cellular senescence") increases bp(MESH:"Cell Survival") |
| pmid:30126037 | bp(GO:"cellular senescence") increases bp(MESH:"Cell Survival") |
| pmid:30126037 | bp(GO:"cellular senescence") association bp(MESH:"Cell Survival") |
| pmid:30126037 | bp(GO:"cellular senescence") increases bp(GO:"tissue remodeling") |
| pmid:30126037 | bp(GO:"cellular senescence") increases bp(GO:"tissue remodeling") |
| pmid:30126037 | bp(GO:"cellular senescence") decreases bp(GO:"metabolic process") |
| pmid:30126037 | bp(GO:"cellular senescence") decreases bp(GO:"metabolic process") |
| pmid:30126037 | bp(GO:"cellular senescence") association p(MGI:Cdkn2a) |
| pmid:30126037 | bp(GO:"cellular senescence") increases a(GO:"neurofibrillary tangle") |
| pmid:30126037 | bp(GO:"cellular senescence") association a(GO:"neurofibrillary tangle") |
| pmid:30126037 | bp(GO:"cellular senescence") increases bp(GO:"neuron death") |
| pmid:30126037 | bp(GO:"cellular senescence") increases path(MESH:"Hypertrophy, Right Ventricular") |
| pmid:30126037 | bp(GO:"cellular senescence") increases path(MESH:"Hypertrophy, Left Ventricular") |
| pmid:30126037 | bp(GO:"cellular senescence") increases bp(HP:Neurodegeneration) |
| pmid:30126037 | bp(GO:"cellular senescence") association path(MESH:Tauopathies) |
| pmid:30126037 | bp(GO:"cellular senescence") increases bp(GO:"cell cycle arrest") |
| pmid:30126037 | bp(GO:"cellular senescence") decreases sec(a(MESH:Immunotoxins)) |
| pmid:30126037 | bp(GO:"cellular senescence") increases bp(MESH:"DNA Damage") |
| pmid:30126037 | bp(GO:"cellular senescence") association bp(MESH:"DNA Damage") |
| pmid:30126037 | bp(GO:"cellular senescence") increases p(MGI:Cdkn1a) |
| pmid:30126037 | bp(GO:"cellular senescence") increases p(HGNC:CDKN2A) |
| pmid:30126037 | bp(GO:"cellular senescence") association bp(GO:"inflammatory response") |
| pmid:30126037 | bp(GO:"cellular senescence") increases bp(HBP:HBP00037) |
| pmid:29221819 | bp(GO:"cellular senescence") positiveCorrelation p(MGI:Dyrk1a) |
| pmid:30126037 | p(MGI:Cdkn2a) association bp(GO:"cellular senescence") |
| pmid:30126037 | p(MGI:Cdkn2a) positiveCorrelation path(HP:"Cerebral atrophy") |
| pmid:30126037 | p(MGI:Cdkn2a) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:30126037 | p(MGI:Cdkn2a) positiveCorrelation path(HP:"Brain atrophy") |
| pmid:30126037 | path(HP:"Cerebral atrophy") positiveCorrelation p(MGI:Cdkn2a) |
| pmid:30126037 | path(MESH:"Hypertrophy, Right Ventricular") association a(GO:"neurofibrillary tangle") |
| pmid:30126037 | path(MESH:"Hypertrophy, Left Ventricular") association a(GO:"neurofibrillary tangle") |
| pmid:23702978 | p(HGNC:NFKB1) increases p(HGNC:IL1B) |
| pmid:27314526 | p(HGNC:TLR4) increases bp(GO:"cytokine secretion") |
| pmid:30126037 | bp(MESH:"DNA Damage") association bp(GO:"cellular senescence") |
| pmid:30126037 | p(MGI:H2afx) biomarkerFor bp(MESH:"DNA Breaks, Double-Stranded") |
| pmid:30126037 | p(MGI:H2afx) biomarkerFor bp(GO:"cellular senescence") |
| pmid:30126037 | p(HGNC:CDKN2A) association a(GO:"neurofibrillary tangle") |
| pmid:30126037 | p(HGNC:CDKN2A) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:30126037 | p(HGNC:CDKN2A) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:30126037 | p(HGNC:CDKN2A) association bp(HP:Neurodegeneration) |
| pmid:30126037 | p(HGNC:CDKN2A) association path(MESH:"Cognitive Dysfunction") |
| pmid:30126037 | p(MGI:Glb1) positiveCorrelation a(HP:brain) |
| pmid:30126037 | a(HP:brain) positiveCorrelation p(MGI:Glb1) |
| pmid:30126037 | bp(GO:"oxidative phosphorylation") decreases bp(GO:"oxygen transport") |
| pmid:30126037 | path(HP:"Brain atrophy") positiveCorrelation p(MGI:Cdkn2a) |
| pmid:30126037 | path(HP:"Brain atrophy") association a(GO:"neurofibrillary tangle") |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle") |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle") |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle") |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(GO:"cellular senescence") |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(GO:"cellular senescence") |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"Brain atrophy") |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"cardiac ventricle") |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"Hyperintensity of cerebral white matter on MRI") |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(MESH:"Cerebrovascular Circulation") |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Syp) |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Rbfox3) |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Dlg4) |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Aif1) |
| pmid:30126037 | composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases bp(MESH:Neuroprotection) |
| pmid:30126037 | path(MESH:"Cerebral Small Vessel Diseases") increases path(HP:"Hyperintensity of cerebral white matter on MRI") |
| pmid:30126037 | path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:Ischemia) |
| pmid:30126037 | path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:"Cognitive Dysfunction") |
| pmid:30126037 | path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:Dementia) |
| pmid:28408124 | a(HBP:"Tau antibody, Tau-13") decreases p(MGI:Mapt, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, Tau-13") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, Tau-13") decreases p(HGNC:MAPT, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, Tau-13") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, 6C5") decreases p(MGI:Mapt, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, 6C5") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, 6C5") decreases p(HGNC:MAPT, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, 6C5") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, 6C5") decreases p(HGNC:MAPT) |
| pmid:28408124 | a(HBP:"Tau antibody, 6C5") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, HT7") decreases p(MGI:Mapt, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, HT7") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, HT7") decreases p(HGNC:MAPT, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, HT7") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, 40E8") decreases p(MGI:Mapt, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, 40E8") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, 40E8") decreases p(HGNC:MAPT, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, 40E8") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, 40E8") decreases p(HGNC:MAPT) |
| pmid:28408124 | a(HBP:"Tau antibody, 40E8") decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:28408124 | a(HBP:"Tau antibody, pS396") decreases p(MGI:Mapt, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, pS396") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, pS396") decreases p(HGNC:MAPT, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, pS396") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, pS396") decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:28408124 | a(HBP:"Tau antibody, 4E4") decreases p(MGI:Mapt, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, 4E4") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, 4E4") decreases p(HGNC:MAPT, loc(GO:cell)) |
| pmid:28408124 | a(HBP:"Tau antibody, 4E4") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, Tau46") causesNoChange tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:28408124 | a(HBP:"Tau antibody, Tau46") association p(HGNC:MAPT) |
| pmid:22419736 | p(HGNC:AK1) positiveCorrelation p(HGNC:APP, var("c.27269938A>C"), var("c.27269939G>T")) |
| pmid:22419736 | p(HGNC:AK1) positiveCorrelation p(HGNC:APP) |
| pmid:22419736 | p(HGNC:AK1) decreases act(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pmid:22419736 | act(p(HGNC:AK1)) association a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:22419736 | p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Ser, 202))) |
| pmid:22419736 | p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Ser, 396))) |
| pmid:22419736 | p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Ser, 404))) |
| pmid:22419736 | p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Ser, 231))) |
| pmid:22419736 | p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Thr, 235))) |
| pmid:22419736 | p(HGNC:AK1) increases p(HBP:"Tau aggregates") |
| pmid:22419736 | p(HGNC:AK1) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:22419736 | p(HGNC:AK1) decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:22419736 | p(HGNC:AK1) regulates p(ECCODE:"2.7.11.31") |
| pmid:22419736 | p(HGNC:AK1) regulates p(HGNC:GSK3B) |
| pmid:22419736 | p(HGNC:AK1) increases path(MESH:"Retinal Degeneration") |
| pmid:22419736 | p(HGNC:AK1) increases path(MESH:"Retinal Degeneration") |
| pmid:22419736 | p(HGNC:AK1) increases act(p(HGNC:MAPT)) |
| pmid:22419736 | p(HGNC:APP, var("c.27269938A>C"), var("c.27269939G>T")) positiveCorrelation p(HGNC:AK1) |
| pmid:22419736 | act(p(ECCODE:"2.7.11.31")) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:22419736 | p(ECCODE:"2.7.11.31") decreases p(ECCODE:"2.7.11.31", pmod(Ph, Thr, 172)) |
| pmid:22419736 | p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:22419736 | p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:22419736 | p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 396)) |
| pmid:22419736 | p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 396)) |
| pmid:22419736 | p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 404)) |
| pmid:22419736 | p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 404)) |
| pmid:22419736 | p(ECCODE:"2.7.11.31") decreases act(p(HGNC:GSK3B)) |
| pmid:22419736 | p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph)) |
| pmid:26751493 | p(HBP:"Tau aggregates") association a(CHEBI:heparin) |
| pmid:26751493 | p(HBP:"Tau aggregates") increases complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) |
| pmid:26751493 | p(HBP:"Tau aggregates") partOf complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) |
| pmid:26751493 | p(HBP:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 274)) |
| pmid:19517062 | p(HBP:"Tau aggregates") increases bp(GO:"apoptotic process") |
| pmid:19517062 | p(HBP:"Tau aggregates") increases bp(GO:"necrotic cell death") |
| pmid:28760828 | p(HBP:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 324)) |
| pmid:28500862 | p(HBP:"Tau aggregates") positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:22419736 | p(HBP:"AK1 R132A") causesNoChange p(ECCODE:"2.7.11.31", pmod(Ph, Thr, 172)) |
| pmid:24183963 | p(HGNC:GSK3B, pmod(Ph, Ser, 9)) decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:29121589 | p(HGNC:GSK3B, pmod(Ph, Ser, 9)) decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:29844403 | p(HGNC:GSK3B, pmod(Ph, Ser, 9)) directlyDecreases act(p(HGNC:GSK3B)) |
| pmid:21734277 | p(HGNC:GSK3B, pmod(Ph, Ser, 9)) directlyDecreases act(p(HGNC:GSK3B)) |
| pmid:25331948 | p(HGNC:GSK3B, pmod(Ph, Ser, 9)) negativeCorrelation act(p(HGNC:SYK)) |
| pmid:22419736 | a(HBP:acadesine) increases act(p(ECCODE:"2.7.11.31")) |
| pmid:22419736 | path(MESH:"Retinal Degeneration") association p(HGNC:MAPT, pmod(Ph)) |
| pmid:29686391 | a(HBP:"sonicated tau fibrils") positiveCorrelation tloc(a(HBP:"sonicated tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | tloc(a(HBP:"sonicated tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation a(HBP:"sonicated tau fibrils") |
| pmid:29686391 | g(HGNC:TP53) increases bp(GO:"mitotic G1 phase") |
| pmid:29686391 | g(HGNC:TP53) decreases bp(GO:"cell proliferation") |
| pmid:29686391 | bp(GO:"mitotic G1 phase") positiveCorrelation bp(GO:endocytosis) |
| pmid:29686391 | bp(GO:"mitotic G1 phase") regulates tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:CDK6) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | a(CHEBI:palbociclib) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | a(CHEBI:palbociclib) decreases act(p(HGNC:CDK4)) |
| pmid:29686391 | a(CHEBI:palbociclib) decreases act(p(HGNC:CDK6)) |
| pmid:29686391 | p(HGNC:EXT2) association bp(GO:"heparan sulfate proteoglycan biosynthetic process") |
| pmid:29686391 | p(HGNC:EXT2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:EXT2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:EXT2) increases tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | bp(GO:"heparan sulfate proteoglycan biosynthetic process") association p(HGNC:EXT2) |
| pmid:29686391 | bp(GO:"heparan sulfate proteoglycan biosynthetic process") association p(HGNC:HS6ST1) |
| pmid:29686391 | p(HGNC:HS6ST1) association bp(GO:"heparan sulfate proteoglycan biosynthetic process") |
| pmid:29686391 | p(HGNC:HS6ST1) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:HS6ST1) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:HS6ST1) increases tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:HS6ST1) increases a(HBP:"6-O-sulfated heparin") |
| pmid:29686391 | p(HGNC:DNM2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:DNM2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:DNM2) increases tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | a(HBP:"6-O-sulfated heparin") positiveCorrelation complex(a(HBP:"6-O-sulfated heparin"), a(HBP:"Tau isoform F (441 aa)")) |
| pmid:29686391 | a(HBP:"6-O-sulfated heparin") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | a(HBP:"6-O-sulfated heparin") association tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | a(HBP:"6-O-sulfated heparin") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | a(MESH:"Heparitin Sulfate") decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | complex(a(HBP:"6-O-sulfated heparin"), a(HBP:"Tau isoform F (441 aa)")) positiveCorrelation a(HBP:"6-O-sulfated heparin") |
| pmid:29686391 | a(HBP:"2-O-sulfated heparin") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | a(HBP:"2-O-sulfated heparin") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | a(CHEBI:"chondroitin sulfate") decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | a(CHEBI:"chondroitin sulfate") causesNoChange tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:SULF1) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:SULF1) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:SULF1) decreases a(HBP:"6-O-sulfated heparin") |
| pmid:29686391 | p(HGNC:SULF2) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:SULF2) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) |
| pmid:29686391 | p(HGNC:SULF2) decreases a(HBP:"6-O-sulfated heparin") |
| pmid:28420982 | a(HBP:"granular tau oligomers") increases a(HBP:"Tau fibrils") |
| pmid:28420982 | bp(GO:"mitochondrion organization") decreases bp(HP:Neurodegeneration) |
| pmid:28420982 | a(MESH:Exosomes) association sec(p(HGNC:MAPT)) |
| pmid:29238289 | act(a(MESH:Exosomes)) association p(HGNC:MAPT) |
| pmid:28420982 | a(MESH:Exosomes) association path(MESH:"Plaque, Amyloid") |
| pmid:28420982 | a(MESH:Exosomes) association p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:28420982 | a(GO:microvesicle) association sec(p(HGNC:MAPT)) |
| pmid:28420982 | a(GO:microvesicle) regulates sec(p(HGNC:MAPT)) |
| pmid:28420982 | complex(a(GO:vesicle), a(MESH:"Cell Membrane")) increases sec(p(HGNC:MAPT)) |
| pmid:28420982 | complex(p(HGNC:CHRM1), p(HGNC:MAPT)) increases path(MESH:Tauopathies) |
| pmid:28420982 | complex(p(HGNC:CHRM3), p(HGNC:MAPT)) increases path(MESH:Tauopathies) |
| pmid:28420982 | complex(a(HBP:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular space"), toLoc(GO:"intracellular part")) |
| pmid:28420982 | complex(a(HBP:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases a(HBP:"Tau aggregates") |
| pmid:28420982 | complex(a(HBP:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases complex(a(GO:"cell surface"), a(HBP:"Tau aggregates")) |
| pmid:28420982 | complex(a(HBP:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases bp(GO:macropinocytosis) |
| pmid:28420982 | a(MESH:"Heparan Sulfate Proteoglycans") association bp(GO:"neurofibrillary tangle assembly") |
| pmid:28420982 | a(MESH:"Heparan Sulfate Proteoglycans") association a(HBP:"dense core plaques") |
| pmid:28420982 | a(MESH:"Heparan Sulfate Proteoglycans") association path(MESH:"Cerebral Amyloid Angiopathy, Familial") |
| pmid:28420982 | a(MESH:"Heparan Sulfate Proteoglycans") increases a(HBP:"Tau fibrils") |
| pmid:28420982 | a(MESH:"Heparan Sulfate Proteoglycans") increases a(HBP:"amyloid-beta fibrils") |
| pmid:28420982 | a(MESH:"Heparan Sulfate Proteoglycans") increases complex(a(GO:"cell surface"), a(HBP:"Tau aggregates")) |
| pmid:28420982 | a(MESH:"Heparan Sulfate Proteoglycans") increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular space"), toLoc(GO:"intracellular part")) |
| pmid:28420982 | a(HBP:"dense core plaques") association a(MESH:"Heparan Sulfate Proteoglycans") |
| pmid:28420982 | a(HBP:"Tau annular protofibrils") association path(MESH:Tauopathies) |
| pmid:28420982 | complex(p(HGNC:DNM1L), p(HGNC:MAPT)) increases bp(HP:Neurodegeneration) |
| pmid:28420982 | p(HGNC:MAPT, frag("1_421")) decreases bp(GO:"mitochondrion organization") |
| pmid:28420982 | p(HGNC:MAPT, frag("421_?")) decreases bp(GO:"mitochondrion organization") |
| pmid:23702978 | tloc(p(HGNC:CYCS), fromLoc(MESH:Mitochondria), toLoc(MESH:Cytosol)) increases act(complex(GO:apoptosome)) |
| pmid:23702978 | tloc(p(HGNC:CYCS), fromLoc(MESH:Mitochondria), toLoc(MESH:Cytosol)) increases complex(p(HGNC:APAF1), p(HGNC:CYCS)) |
| pmid:28420982 | complex(p(HGNC:APAF1), p(HGNC:CYCS)) increases act(p(HGNC:CASP9)) |
| pmid:23702978 | complex(p(HGNC:APAF1), p(HGNC:CYCS)) increases bp(GO:"apoptosome assembly") |
| pmid:29311797 | path(MESH:"Chronic Traumatic Encephalopathy") isA path(MESH:Tauopathies) |
| pmid:29276758 | path(MESH:"Chronic Traumatic Encephalopathy") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) |
| pmid:29311797 | p(HGNC:HSP90AA1) association bp(GO:growth) |
| pmid:29311797 | p(HGNC:HSP90AA1) association bp(GO:"regulation of cell cycle") |
| pmid:29311797 | p(HGNC:HSP90AA1) association bp(MESH:Cytoprotection) |
| pmid:29311797 | p(HGNC:HSP90AA1) association path(MESH:"Neoplasm Metastasis") |
| pmid:29311797 | bp(GO:growth) association p(HGNC:HSP90AA1) |
| pmid:29311797 | bp(GO:"regulation of cell cycle") association p(HGNC:HSP90AA1) |
| pmid:29311797 | bp(MESH:Cytoprotection) association p(HGNC:HSP90AA1) |
| pmid:29311797 | path(MESH:"Neoplasm Metastasis") association p(HGNC:HSP90AA1) |
| pmid:29311797 | bp(GO:"embryo development") association p(HGNC:HSP90AB1) |
| pmid:29311797 | bp(GO:"cell maturation") association p(HGNC:HSP90AB1) |
| pmid:29311797 | bp(GO:"cytoskeleton organization") association p(HGNC:HSP90AB1) |
| pmid:29311797 | bp(GO:"adaptation of signaling pathway") association p(HGNC:HSP90AB1) |
| pmid:29311797 | p(HGNC:PPID) isA a(MESH:Immunophilins) |
| pmid:29311797 | p(HGNC:PPID) decreases a(HBP:"Tau fibrils") |
| pmid:29311797 | p(HGNC:PPID) decreases a(HBP:"Tau aggregates") |
| pmid:29311797 | p(HGNC:PPID) increases bp(GO:memory) |
| pmid:29311797 | p(HGNC:PPID) decreases bp(GO:"neuron apoptotic process") |
| pmid:29311797 | p(HGNC:FKBPL) isA a(MESH:Immunophilins) |
| pmid:29311797 | complex(p(FPLX:HSP90), p(HGNC:AIP)) regulates bp(GO:"glucocorticoid receptor signaling pathway") |
| pmid:29311797 | bp(GO:"glucocorticoid receptor signaling pathway") association a(HBP:"Tau aggregates") |
| pmid:29311797 | p(HGNC:MAPT, pmod(HBP:misfolding)) increases bp(GO:"cell death in response to oxidative stress") |
| pmid:29311797 | p(HGNC:TOMM34) decreases path(MESH:Tauopathies) |
| pmid:29311797 | complex(p(FPLX:HSP90), p(HGNC:CDC37)) increases p(HGNC:GSK3B) |
| pmid:29311797 | complex(p(FPLX:HSP90), p(HGNC:CDC37)) increases p(HGNC:MAPK13) |
| pmid:29311797 | act(p(HGNC:MAPK13), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:11943212 | p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:11943212 | p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Thr, 396)) |
| pmid:11943212 | p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:11943212 | p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:29311797 | p(HGNC:S100A1) increases p(HGNC:MAPT) |
| pmid:29311797 | p(HGNC:S100A1) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29311797 | complex(p(FPLX:HSP90), p(HGNC:FNIP1)) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pmid:29311797 | complex(p(FPLX:HSP90), p(HGNC:FNIP1), p(HGNC:FNIP2)) increases p(HGNC:FLCN) |
| pmid:29311797 | p(FPLX:HSP90, pmod(Ph)) decreases act(p(FPLX:HSP90)) |
| pmid:29311797 | p(FPLX:HSP90, pmod(Ac)) decreases complex(a(CHEBI:ATP), p(FPLX:HSP90)) |
| pmid:29311797 | p(FPLX:HSP90, pmod(NO)) decreases act(p(FPLX:HSP90)) |
| pmid:29311797 | p(FPLX:HSP90, pmod(Ub)) decreases act(p(FPLX:HSP90)) |
| pmid:29311797 | a(HBP:EC102) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) |
| pmid:29311797 | a(PUBCHEM:14719853) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) |
| pmid:29311797 | a(PUBCHEM:14719853) decreases p(HGNC:MAPT) |
| pmid:29311797 | a(CHEBI:"withaferin A") decreases act(p(FPLX:HSP90)) |
| pmid:29311797 | a(CHEBI:"withaferin A") decreases p(HGNC:MAPT) |
| pmid:29311797 | a(PUBCHEM:162859) decreases complex(p(FPLX:HSP90), p(HGNC:CDC37)) |
| pmid:29311797 | a(PUBCHEM:4456430) decreases path(MESH:"Alzheimer Disease") |
| pmid:29311797 | a(HBP:"KU-177") decreases p(HGNC:MAPT, var("p.Pro301Leu")) |
| pmid:26751493 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:29121589 | p(HGNC:MAPT, var("p.Pro301Leu")) increases a(HBP:Astrogliosis) |
| pmid:29121589 | p(HGNC:MAPT, var("p.Pro301Leu")) increases a(HBP:Microgliosis) |
| pmid:29121589 | p(HGNC:MAPT, var("p.Pro301Leu")) increases r(MGI:Il1b) |
| pmid:29121589 | p(HGNC:MAPT, var("p.Pro301Leu")) increases r(MGI:Nos2) |
| pmid:23294633 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(MGI:Gsk3b, pmod(Ph, Tyr, 279)) |
| pmid:23294633 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(MGI:Gsk3b, pmod(Ph, Tyr, 216)) |
| pmid:23294633 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:23294633 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:23294633 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation a(HBP:"Tau epitope, AT100") |
| pmid:23294633 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:11606569 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HBP:"VQIINK motif") |
| pmid:11606569 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HBP:"VQIVYK motif") |
| pmid:27716675 | p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation a(HBP:neuroinflammation) |
| pmid:26751493 | r(MGI:Mapt) partOf a(CL:0000127) |
| pmid:26751493 | r(MGI:Mapt) partOf a(CL:0000128) |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28877763 | p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation p(HGNC:SYK, pmod(Ph)) |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 68)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Thr, 69)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Thr, 71)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 113)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Thr, 123)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Thr, 153)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Thr, 175)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Thr, 184)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 185)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 191)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Tyr, 197)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 210)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 214)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:28176663 | p(HGNC:MAPT, pmod(Ph, Ser, 214)) positiveCorrelation a(CHEBI:"D-ribose") |
| pmid:8226987 | p(HGNC:MAPT, pmod(Ph, Ser, 214)) decreases act(p(HGNC:MAPT)) |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 237)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 238)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 258)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 289)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Tyr, 394)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Thr, 403)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 409)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 435)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Thr, 427)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 433)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf p(HBP:"Tau aggregates") |
| pmid:22817713 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) association a(HBP:"Tau oligomers") |
| pmid:26671985 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy") |
| pmid:26671985 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) increases path(MESH:"Cognitive Dysfunction") |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(FPLX:PKA) |
| pmid:18239272 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf a(GO:"neurofibrillary tangle") |
| pmid:18239272 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf a(MESH:"Neuropil Threads") |
| pmid:18239272 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf path(MESH:"Plaque, Amyloid") |
| pmid:18239272 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) association a(HBP:pretangles) |
| pmid:11943212 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf p(HBP:"Tau epitope, AP422") |
| pmid:26118667 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) negativeCorrelation m(MIRBASE:"rno-mir-195") |
| pmid:23294633 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pmid:27373205 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(HBP:"phosphatase-activating domain") |
| pmid:27373205 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(HBP:"Tau dimers") |
| pmid:27373205 | p(HGNC:MAPT, pmod(Ph, Ser, 422)) decreases bp(GO:"anterograde axonal transport") |
| pmid:26751493 | p(HBP:"microtubule-binding region") association p(HGNC:HDAC6) |
| pmid:26751493 | p(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) |
| pmid:10464280 | p(HBP:"microtubule-binding region") isA p(HGNC:MAPT) |
| pmid:10464280 | p(HBP:"microtubule-binding region") association act(complex(SCOMP:"PP2A Complex")) |
| pmid:10464280 | p(HBP:"microtubule-binding region") positiveCorrelation act(complex(GO:microtubule)) |
| pmid:18500754 | p(HBP:"microtubule-binding region") association p(HGNC:HSPA8) |
| pmid:18500754 | p(HBP:"microtubule-binding region") association p(INTERPRO:"Heat shock protein 70kD, C-terminal domain superfamily") |
| pmid:8391280 | p(HBP:"microtubule-binding region") association p(FPLX:Ubiquitin) |
| pmid:26751493 | p(HBP:"tubulin-binding repeat 1") association g(HBP:"APOE e3") |
| pmid:26751493 | p(HBP:"tubulin-binding repeat 1") partOf p(HBP:"microtubule-binding region") |
| pmid:17493042 | p(HBP:"tubulin-binding repeat 1") partOf a(HBP:"microtubule-binding region") |
| pmid:26751493 | p(HBP:"tubulin-binding repeat 1") partOf a(HBP:"microtubule-binding region") |
| pmid:17493042 | p(HBP:"tubulin-binding repeat 1") equivalentTo p(HBP:"Tau isoform F (441 aa)", frag("244_274")) |
| pmid:23407988 | p(HBP:"tubulin-binding repeat 1") partOf p(HBP:"4R tau") |
| pmid:23407988 | p(HBP:"tubulin-binding repeat 1") partOf p(HBP:"3R tau") |
| pmid:26751493 | p(HBP:"tubulin-binding repeat 1") association p(HBP:"APOE e3") |
| pmid:26751493 | g(HBP:"APOE e3") association p(HBP:"tubulin-binding repeat 1") |
| pmid:26751493 | p(HBP:"projection domain") association p(HGNC:LCK) |
| pmid:26751493 | p(HBP:"projection domain") association p(HGNC:FGR) |
| pmid:26751493 | p(HBP:"projection domain") association p(HGNC:SRC) |
| pmid:26751493 | p(HBP:"projection domain") association p(HGNC:GRB2) |
| pmid:26751493 | p(HBP:"projection domain") association p(FPLX:PLC) |
| pmid:26751493 | p(HBP:"projection domain") association a(CHEBI:phosphatidylinositol) |
| pmid:26751493 | p(HBP:"projection domain") association a(CHEBI:"phosphatidylinositol bisphosphate") |
| pmid:26751493 | p(HBP:"projection domain") association p(HGNC:PIN1) |
| pmid:26751493 | p(HBP:"projection domain") partOf p(HGNC:MAPT) |
| pmid:26751493 | p(HBP:"projection domain") association p(HGNC:FYN) |
| pmid:26751493 | p(HBP:"projection domain") association p(HGNC:DLG4) |
| pmid:26751493 | p(HBP:"projection domain") association a(MESH:"Receptors, N-Methyl-D-Aspartate") |
| pmid:26751493 | p(HGNC:LCK) association p(HBP:"projection domain") |
| pmid:26751493 | p(HGNC:LCK) association a(HBP:"projection domain") |
| pmid:26751493 | p(HGNC:FGR) association p(HBP:"projection domain") |
| pmid:26751493 | p(HGNC:FGR) association a(HBP:"projection domain") |
| pmid:26751493 | p(HGNC:GRB2) association p(HBP:"projection domain") |
| pmid:26751493 | p(HGNC:GRB2) association a(HBP:"projection domain") |
| pmid:26751493 | a(CHEBI:"phosphatidylinositol bisphosphate") association p(HBP:"projection domain") |
| pmid:26751493 | a(CHEBI:"phosphatidylinositol bisphosphate") association a(HBP:"projection domain") |
| pmid:26751493 | p(HBP:"4R tau") positiveCorrelation path(HBP:"Corticobasal Degeneration") |
| pmid:26751493 | p(HBP:"4R tau") positiveCorrelation path(HBP:"Argyrophilic Grain Disease") |
| pmid:26751493 | p(HBP:"4R tau") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:23407988 | p(HBP:"4R tau") isA p(HGNC:MAPT) |
| pmid:23407988 | p(HBP:"4R tau") partOf a(HBP:pretangles) |
| pmid:23407988 | p(HBP:"4R tau") partOf complex(GO:"neurofibrillary tangle") |
| pmid:23407988 | p(HBP:"4R tau") positiveCorrelation a(HBP:"CA4 field of hippocampus") |
| pmid:23407988 | p(HBP:"4R tau") positiveCorrelation a(HBP:"CA3 field of hippocampus") |
| pmid:23407988 | p(HBP:"4R tau") positiveCorrelation a(HBP:"CA2 field of hippocampus") |
| pmid:23407988 | p(HBP:"4R tau") positiveCorrelation a(HBP:"CA1 field of hippocampus") |
| pmid:23407988 | p(HBP:"4R tau") positiveCorrelation a(HBP:"Brodmann (1909) area 36") |
| pmid:23407988 | p(HBP:"4R tau") partOf complex(GO:"neuronal cell body") |
| pmid:23407988 | p(HBP:"4R tau") partOf complex(GO:dendrite) |
| pmid:23407988 | p(HBP:"4R tau") partOf a(MESH:Neuropil) |
| pmid:28775333 | p(HBP:"4R tau") negativeCorrelation p(MGI:Dyrk1a) |
| pmid:21427723 | p(HBP:"4R tau") partOf path(HBP:"4R tauopathy") |
| pmid:27574109 | p(HBP:"4R tau") positiveCorrelation p(HBP:"phosphatase-activating domain") |
| pmid:26751493 | path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HBP:"4R tau") |
| pmid:22057784 | path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) |
| pmid:17050703 | path(HBP:"Corticobasal Degeneration") association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) |
| pmid:21427723 | path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) |
| pmid:21427723 | path(HBP:"Corticobasal Degeneration") isA path(HBP:"4R tauopathy") |
| pmid:26751493 | path(HBP:"Argyrophilic Grain Disease") positiveCorrelation p(HBP:"4R tau") |
| pmid:26751493 | p(HBP:"3R tau") positiveCorrelation path(MESH:"Niemann-Pick Diseases") |
| pmid:23407988 | p(HBP:"3R tau") isA p(HGNC:MAPT) |
| pmid:23407988 | p(HBP:"3R tau") partOf complex(GO:"neurofibrillary tangle") |
| pmid:23407988 | p(HBP:"3R tau") partOf a(HBP:"ghost tangles") |
| pmid:23407988 | p(HBP:"3R tau") partOf a(HBP:"Brodmann (1909) area 36") |
| pmid:23407988 | p(HBP:"3R tau") partOf a(HBP:"CA1 field of hippocampus") |
| pmid:23407988 | p(HBP:"3R tau") partOf a(HBP:"CA2 field of hippocampus") |
| pmid:23407988 | p(HBP:"3R tau") partOf a(HBP:"CA3 field of hippocampus") |
| pmid:23407988 | p(HBP:"3R tau") partOf a(HBP:"CA4 field of hippocampus") |
| pmid:23407988 | p(HBP:"3R tau") partOf complex(GO:dendrite) |
| pmid:23407988 | p(HBP:"3R tau") partOf a(MESH:Neuropil) |
| pmid:23407988 | p(HBP:"3R tau") partOf complex(GO:"neuronal cell body") |
| pmid:26655600 | p(HBP:"3R tau") negativeCorrelation bp(GO:"neurofibrillary tangle assembly") |
| pmid:26655600 | p(HBP:"3R tau") positiveCorrelation complex(GO:"Pick body") |
| pmid:28775333 | p(HBP:"3R tau") positiveCorrelation p(MGI:Dyrk1a) |
| pmid:28775333 | p(HBP:"3R tau") negativeCorrelation a(CHEBI:"(-)-epigallocatechin 3-gallate") |
| pmid:26751493 | path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HBP:"3R tau") |
| pmid:26751493 | path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HGNC:PSEN1, var("p.Gly183Val")) |
| pmid:26751493 | p(HGNC:MAPT, var("p.Val337Met")) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:26751493 | p(HGNC:MAPT, var("p.Gly272Val")) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:26751493 | p(HGNC:MAPT, var("p.Arg406Trp")) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:26751493 | p(HGNC:PSEN1, var("p.Gly183Val")) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:26751493 | p(HGNC:PSEN1, var("p.Gly183Val")) positiveCorrelation path(MESH:"Niemann-Pick Diseases") |
| pmid:26751493 | p(HGNC:PSEN1, var("p.Gly183Val")) causesNoChange a(CHEBI:"amyloid-beta") |
| pmid:26751493 | g(DBSNP:rs2471738) association path(MESH:"Parkinson Disease") |
| pmid:26751493 | g(DBSNP:rs242557) association path(MESH:"Parkinson Disease") |
| pmid:26751493 | p(HGNC:MAPT, var("p.Glu391*")) association p(HBP:"paired helical filaments") |
| pmid:25974414 | p(HGNC:MAPT, var("p.Glu391*")) partOf a(GO:"neurofibrillary tangle") |
| pmid:22002427 | p(HGNC:MAPT, var("p.Glu391*")) partOf a(GO:"neurofibrillary tangle") |
| pmid:25974414 | p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25974414 | p(HGNC:MAPT, var("p.Glu391*")) isA p(HGNC:MAPT) |
| pmid:22002427 | p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:22002427 | p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 205)) |
| pmid:26751493 | p(HBP:"paired helical filaments") association p(HGNC:MAPT, var("p.Glu391*")) |
| pmid:26751493 | p(HBP:"paired helical filaments") partOf a(GO:"neurofibrillary tangle") |
| pmid:26751493 | p(HGNC:SNAP25) negativeCorrelation a(GO:"neurofibrillary tangle") |
| pmid:26751493 | p(PFAM:Syntaxin) negativeCorrelation a(GO:"neurofibrillary tangle") |
| pmid:26751493 | complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) positiveCorrelation bp(GO:macropinocytosis) |
| pmid:26751493 | bp(GO:"cell-cell signaling via exosome") isA tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) |
| pmid:26751493 | a(CL:0000129) increases tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) |
| pmid:26751493 | a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") decreases act(p(ECCODE:"3.1.1.89")) |
| pmid:26751493 | a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") positiveCorrelation act(complex(GO:"respiratory chain complex I")) |
| pmid:29281045 | p(ECCODE:"3.1.1.89") decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) |
| pmid:26751493 | act(complex(GO:"respiratory chain complex I")) positiveCorrelation a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") |
| pmid:26751493 | p(HBP:"Tau antibody, RG7345") decreases p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:28019679 | p(HGNC:CASP1) increases act(p(HGNC:IL18)) |
| pmid:23702978 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) |
| pmid:23702978 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) |
| pmid:23702978 | act(p(HGNC:CASP1)) increases sec(p(HGNC:IL18)) |
| pmid:24561250 | p(HGNC:CASP1) increases p(HGNC:IL18) |
| pmid:24561250 | p(HGNC:CASP1) increases p(HGNC:IL18) |
| pmid:27314526 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) |
| pmid:27314526 | sec(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) |
| pmid:27314526 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) |
| pmid:27314526 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) |
| pmid:28019679 | p(HGNC:CASP1) increases act(p(HGNC:IL1B)) |
| pmid:23702978 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) |
| pmid:23702978 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) |
| pmid:23702978 | act(p(HGNC:CASP1)) increases sec(p(HGNC:IL1B)) |
| pmid:23702978 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) |
| pmid:24561250 | p(HGNC:CASP1) increases p(HGNC:IL1B) |
| pmid:27314526 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) |
| pmid:27314526 | sec(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) |
| pmid:27314526 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) |
| pmid:27314526 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) |
| pmid:28019679 | act(p(HGNC:CASP1)) increases a(CHEBI:"nitric oxide") |
| pmid:28019679 | act(p(HGNC:CASP1)) increases sec(p(HGNC:TNF)) |
| pmid:28019679 | act(p(HGNC:CASP1)) increases bp(GO:pyroptosis) |
| pmid:23702978 | act(p(HGNC:CASP1)) increases bp(GO:pyroptosis) |
| pmid:24561250 | p(HGNC:CASP1) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pmid:27314526 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL33)) |
| pmid:27314526 | act(p(HGNC:CASP1)) increases act(p(HGNC:IL33)) |
| pmid:26751493 | p(HGNC:MAPT, pmod(Ac, Lys, 274)) positiveCorrelation p(HBP:"Tau aggregates") |
| pmid:27041503 | p(HGNC:MAPT, pmod(Ac, Lys, 274)) decreases p(HGNC:WWC1) |
| pmid:27041503 | p(HGNC:MAPT, pmod(Ac, Lys, 274)) decreases bp(GO:"actin filament polymerization") |
| pmid:26751493 | a(HBP:thiohydantoin) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(HBP:oxazolidinedione) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(HBP:thioxooxazolidine) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(CHEBI:thiostrepton) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(HBP:sudoxicam) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(CHEBI:isoniazide) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(CHEBI:Iproniazid) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(CHEBI:iproclozide) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(HBP:isocarboxazide) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(CHEBI:myricetin) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(CHEBI:emodin) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(CHEBI:daunorubicin) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(CHEBI:doxorubicin) decreases p(HBP:"Tau aggregates") |
| pmid:26751493 | a(CHEBI:quinalizarin) decreases p(HBP:"Tau aggregates") |
| pmid:26458742 | p(HBP:HBP00056, var("p.Pro301Leu")) increases p(HBP:HBP00056, pmod(Ph, Thr, 205)) |
| pmid:26458742 | p(HBP:HBP00056, var("p.Pro301Leu")) increases p(HBP:HBP00056, pmod(Ph, Ser, 262)) |
| pmid:26458742 | p(HBP:HBP00056, var("p.Pro301Leu")) increases p(HBP:HBP00056, pmod(Ph, Ser, 400)) |
| pmid:26458742 | p(HBP:HBP00056, var("p.Pro301Leu")) increases p(HBP:HBP00056, pmod(Ph, Ser, 404)) |
| pmid:26458742 | p(HBP:HBP00056, var("p.Pro301Leu")) increases p(HBP:HBP00056, pmod(Ph, Ser, 409)) |
| pmid:26458742 | p(HBP:HBP00056, var("p.Pro301Leu")) increases p(HBP:HBP00056, pmod(Ph, Ser, 422)) |
| pmid:26458742 | p(HBP:HBP00056, var("p.Pro301Leu")) increases a(HBP:HBP00006) |
| pmid:26195256 | bp(GO:"import into cell") decreases a(HBP:"amyloid-beta derived diffusible ligands") |
| pmid:26195256 | a(MESH:"Blood-Brain Barrier") decreases p(CHEBI:"amyloid-beta", loc(GO:"extracellular region")) |
| pmid:26195256 | act(a(MESH:"Blood-Brain Barrier")) association p(HGNC:PPIA) |
| pmid:26195256 | a(MESH:"Extracellular Fluid") decreases p(CHEBI:"amyloid-beta", loc(GO:"extracellular region")) |
| pmid:26195256 | p(HGNC:TREM2) association path(MESH:"Alzheimer Disease") |
| pmid:29626319 | p(HGNC:TREM2) association bp(GO:phagocytosis) |
| pmid:29626319 | act(p(HGNC:TREM2)) increases bp(GO:phagocytosis) |
| pmid:29626319 | act(p(HGNC:TREM2)) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) |
| pmid:26195256 | p(HGNC:CLU) association path(MESH:"Alzheimer Disease") |
| pmid:26195256 | p(HGNC:PICALM) association path(MESH:"Alzheimer Disease") |
| pmid:29626319 | p(HGNC:PICALM) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27260836 | p(HGNC:PICALM) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29626319 | p(HGNC:PICALM) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Blood-Brain Barrier"), toLoc(MESH:Blood)) |
| pmid:29626319 | p(HGNC:PICALM) decreases a(CHEBI:"amyloid-beta") |
| pmid:27260836 | p(HGNC:PICALM) increases complex(p(HBP:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) |
| pmid:27260836 | p(HGNC:PICALM) partOf complex(GO:"neurofibrillary tangle") |
| pmid:27260836 | p(HGNC:PICALM) partOf complex(GO:"neurofibrillary tangle") |
| pmid:27260836 | p(HGNC:PICALM) association p(HGNC:MAPT, pmod(Ph)) |
| pmid:27260836 | p(HGNC:PICALM) association p(HGNC:MAPT, pmod(Ph)) |
| pmid:27260836 | p(HGNC:PICALM) partOf a(HBP:"granulovacuolar degeneration") |
| pmid:27260836 | p(HGNC:PICALM) partOf complex(GO:"Pick body") |
| pmid:27260836 | p(HGNC:PICALM) partOf complex(GO:"Cajal body") |
| pmid:27260836 | p(HGNC:PICALM) negativeCorrelation p(HGNC:MAP1LC3B) |
| pmid:27260836 | p(HGNC:PICALM) positiveCorrelation p(HGNC:BECN1) |
| pmid:26195256 | path(MESH:"Cardiovascular Diseases") association path(MESH:"Alzheimer Disease") |
| pmid:26195256 | path(MESH:Hypertension) association path(MESH:"Alzheimer Disease") |
| pmid:26195256 | path(MESH:"Craniocerebral Trauma") association path(MESH:"Alzheimer Disease") |
| pmid:26195256 | path(MESH:"Sleep Initiation and Maintenance Disorders") association path(MESH:"Alzheimer Disease") |
| pmid:26195256 | path(MESH:"Sleep Initiation and Maintenance Disorders") increases path(MESH:"Alzheimer Disease") |
| pmid:26195256 | a(MESH:"Cerebral Ventricles") association path(MESH:"Alzheimer Disease") |
| pmid:26195256 | p(CHEBI:"amyloid-beta polypeptide 42", loc(MESH:"Cerebrospinal Fluid")) negativeCorrelation p(HGNC:APP, loc(GO:"extracellular region")) |
| pmid:26195256 | act(p(MESH:Ubiquitin)) decreases p(HGNC:APP) |
| pmid:26195256 | act(p(MESH:Ubiquitin)) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) |
| pmid:26195256 | p(MESH:Ubiquitin) decreases p(HGNC:MAPT) |
| pmid:26195256 | act(complex(a(MESH:Endosomes), a(MESH:Lysosomes))) decreases p(HGNC:APP) |
| pmid:26195256 | act(p(MESH:"Amyloid Precursor Protein Secretases")) increases a(CHEBI:"amyloid-beta") |
| pmid:26195256 | a(HBP:"amyloid-beta polypeptide 38") isA a(CHEBI:"amyloid-beta") |
| pmid:26195256 | act(p(MESH:Cathepsins)) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) |
| pmid:26195256 | p(MESH:Neprilysin) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) |
| pmid:26195256 | p(MESH:"Matrix Metalloproteinase 9") decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) |
| pmid:26195256 | p(MESH:"Matrix Metalloproteinase 2") decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) |
| pmid:26195256 | p(MESH:"Matrix Metalloproteinase 3") decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) |
| pmid:26195256 | p(MESH:"Glutamate Carboxypeptidase II") decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) |
| pmid:26195256 | p(MESH:"Endothelin-Converting Enzymes") decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) |
| pmid:26195256 | p(MESH:"Tissue Plasminogen Activator") decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) |
| pmid:26195256 | p(MESH:Fibrinolysin) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) |
| pmid:26195256 | p(HGNC:ACE) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) |
| pmid:29626319 | p(HGNC:ACE) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:ACE) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:ACE) increases rxn(reactants(a(CHEBI:"Angiotensin I")), products(a(CHEBI:"angiotensin II"))) |
| pmid:29626319 | p(HGNC:ACE) regulates a(MESH:"Body Fluids") |
| pmid:29626319 | p(HGNC:ACE) regulates bp(MESH:"Blood Pressure") |
| pmid:29626319 | p(HGNC:ACE) regulates bp(GO:"sodium ion transmembrane transport") |
| pmid:29626319 | act(p(HGNC:ACE)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26195256 | a(MESH:"Muscle, Smooth, Vascular") decreases a(CHEBI:"amyloid-beta") |
| pmid:26195256 | a(MESH:Insulin) increases a(CHEBI:"amyloid-beta") |
| pmid:26195256 | a(MESH:Insulin) association a(CHEBI:"amyloid-beta") |
| pmid:26195256 | p(HGNC:ABCB1) increases tloc(a(CHEBI:"amyloid-beta")) |
| pmid:26195256 | p(HGNC:ABCB1) increases tloc(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:ABCB1) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(GO:"extracellular region")) |
| pmid:29626319 | p(HGNC:ABCB1) decreases a(CHEBI:"amyloid-beta") |
| pmid:26195256 | p(HGNC:A2M) regulates a(CHEBI:"amyloid-beta") |
| pmid:26195256 | p(HGNC:LRP2) regulates a(CHEBI:"amyloid-beta") |
| pmid:26195256 | p(HGNC:PPIA) association act(a(MESH:"Blood-Brain Barrier")) |
| pmid:26195256 | bp(MESH:"Oxidative Stress") increases path(MESH:Aging) |
| pmid:21131359 | bp(MESH:"Oxidative Stress") increases tloc(p(HGNC:MAPT), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pmid:27623715 | bp(MESH:"Oxidative Stress") increases act(p(FPLX:JNK)) |
| pmid:27623715 | bp(MESH:"Oxidative Stress") increases a(CHEBI:"calcium(2+)") |
| pmid:27623715 | bp(MESH:"Oxidative Stress") decreases p(HGNC:S100B) |
| pmid:27623715 | bp(MESH:"Oxidative Stress") causesNoChange bp(GO:"apoptotic process") |
| pmid:27623715 | bp(MESH:"Oxidative Stress") causesNoChange path(MESH:"Acidosis, Lactic") |
| pmid:27623715 | bp(MESH:"Oxidative Stress") causesNoChange bp(GO:"amyloid fibril formation") |
| pmid:23722080 | bp(MESH:"Oxidative Stress") decreases a(GO:mitochondrion) |
| pmid:24355211 | bp(MESH:"Oxidative Stress") positiveCorrelation p(HGNC:GSK3B) |
| pmid:8226987 | bp(MESH:"Oxidative Stress") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:7667312 | bp(MESH:"Oxidative Stress") increases a(HBP:"paired helical filaments") |
| pmid:26195256 | bp(HBP:"perivascular drainage pathways") association a(CHEBI:"amyloid-beta") |
| pmid:26195256 | path(HBP:"high-fat prenatal maternal diet") increases a(CHEBI:"amyloid-beta") |
| pmid:26195256 | path(MESH:Sleep) increases act(a(MESH:"Blood-Brain Barrier")) |
| pmid:26195256 | path(MESH:Sleep) increases bp(HBP:"glymphatic bulk flow") |
| pmid:29626319 | path(MESH:Sleep) decreases a(CHEBI:"amyloid-beta") |
| pmid:26195256 | act(p(MESH:Lysosomes)) decreases p(HGNC:MAPT) |
| pmid:26195256 | p(MESH:"Cyclic AMP-Dependent Protein Kinases") increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:26195256 | act(p(MESH:Calpain)) decreases p(HGNC:MAPT) |
| pmid:26195256 | p(HBP:"tau aggregates") association path(MESH:"Brain Injuries, Traumatic") |
| pmid:27373205 | p(HGNC:MAPT, var("p.S422E")) increases a(HBP:"Tau aggregates") |
| pmid:27373205 | p(HGNC:MAPT, var("p.S422E")) increases a(HBP:"Tau oligomers") |
| pmid:27373205 | p(HGNC:MAPT, var("p.S422E")) decreases bp(GO:"anterograde axonal protein transport") |
| pmid:27373205 | p(HGNC:MAPT, var("p.S422E")) causesNoChange bp(GO:"retrograde axonal protein transport") |
| pmid:27373205 | composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) increases a(HBP:"Tau oligomers") |
| pmid:27373205 | composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) increases a(HBP:"Tau dimers") |
| pmid:27373205 | composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) decreases bp(GO:"anterograde axonal protein transport") |
| pmid:27373205 | composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) decreases bp(GO:"retrograde axonal protein transport") |
| pmid:27373205 | composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT)) increases a(HBP:"Tau oligomers") |
| pmid:27373205 | composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT)) increases a(HBP:"Tau dimers") |
| pmid:27373205 | composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT)) decreases bp(GO:"anterograde axonal protein transport") |
| pmid:27373205 | composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT)) causesNoChange bp(GO:"retrograde axonal protein transport") |
| pmid:22817713 | complex(a(HBP:"Tau oligomers"), p(HGNC:HSPA1A)) decreases bp(GO:"anterograde axonal protein transport") |
| pmid:22817713 | complex(a(HBP:"Tau oligomers"), p(HGNC:HSPA1A)) increases bp(GO:"anterograde axonal protein transport") |
| pmid:22817713 | a(MESH:"Neuropil Threads") association path(MESH:"Alzheimer Disease") |
| pmid:18239272 | a(MESH:"Neuropil Threads") association p(HBP:"Tau epitope, AT8") |
| pmid:22817713 | bp(GO:"regulation of microtubule cytoskeleton organization") association p(HGNC:MAPT) |
| pmid:22817713 | complex(p(HGNC:MAPT), p(HGNC:MAPT)) increases a(HBP:"Tau oligomers") |
| pmid:22817713 | a(CHEBI:"arachidonic acid") increases a(HBP:"Tau oligomers") |
| pmid:22817713 | a(CHEBI:"arachidonic acid") increases a(HBP:"Tau aggregates") |
| pmid:22817713 | p(HGNC:PPP1CA) decreases bp(GO:"anterograde axonal protein transport") |
| pmid:29334120 | p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 397)) |
| pmid:29334120 | p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 403)) |
| pmid:29334120 | p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 404)) |
| pmid:29334120 | p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 409)) |
| pmid:29334120 | p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 410)) |
| pmid:26142647 | act(p(HGNC:PPP1CA)) directlyDecreases p(HGNC:EIF2S1, pmod(Ph)) |
| pmid:21734277 | act(p(HGNC:PPP1CA)) directlyDecreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:21734277 | act(p(HGNC:PPP1CA)) increases act(p(HGNC:GSK3B)) |
| pmid:21734277 | act(p(HGNC:PPP1CA)) negativeCorrelation bp(GO:"axonal transport") |
| pmid:25001178 | act(p(HGNC:PPP1CA)) directlyDecreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:22817713 | p(HGNC:GSK3A) decreases bp(GO:"anterograde axonal protein transport") |
| pmid:22817713 | p(HGNC:MAPT, frag("2_18")) decreases bp(GO:"anterograde axonal protein transport") |
| pmid:26671985 | p(HGNC:MAPT, frag("2_18")) equivalentTo p(HBP:"phosphatase-activating domain") |
| pmid:26671985 | p(HGNC:MAPT, frag("2_18")) partOf p(HGNC:MAPT, frag("1_151")) |
| pmid:22817713 | composite(p(HGNC:HSPA1A), p(HGNC:MAPT, frag("2_18"))) decreases bp(GO:"anterograde axonal protein transport") |
| pmid:29626319 | p(FPLX:UBE2) increases deg(a(MESH:Proteins)) |
| pmid:29626319 | a(MESH:"Ubiquitin-Protein Ligases") increases deg(a(MESH:Proteins)) |
| pmid:29626319 | p(HGNC:PSMD7) increases deg(a(MESH:Proteins)) |
| pmid:29626319 | a(HBP:"20 S Proteasome") increases bp(GO:"proteasomal ubiquitin-independent protein catabolic process") |
| pmid:29626319 | complex(GO:"TOR complex") increases bp(GO:"lysosomal microautophagy") |
| pmid:29626319 | a(MESH:"Tight Junctions") decreases tloc(a(MESH:Proteins), fromLoc(MESH:Brain), toLoc(MESH:Blood)) |
| pmid:29626319 | a(HP:"glymphatic system") decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(HP:"glymphatic system") decreases p(HGNC:MAPT) |
| pmid:29626319 | a(MESH:Liver) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(MESH:Liver) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(MESH:Liver) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(MESH:Liver) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:29626319 | a(MESH:Liver) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:29626319 | p(HGNC:UBB, var("?")) decreases act(p(HGNC:PSMD7)) |
| pmid:29626319 | p(HGNC:UBB, var("?")) decreases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(HBP:"APOE e4") decreases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(HBP:"APOE e4") decreases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(FPLX:MMP) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:ECE1) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:SERPINF2) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:SERPINF2) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:SERPINF2) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29626319 | act(p(HGNC:SERPINF2)) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29626319 | act(p(HGNC:MMP3)) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(MESH:"Receptors, Scavenger") increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:CMKLR1) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(FPLX:TLR) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:23702978 | act(p(FPLX:TLR)) increases p(HGNC:NLRP3) |
| pmid:23702978 | act(p(FPLX:TLR)) increases p(HGNC:IL1B) |
| pmid:29626319 | p(HGNC:FPR2) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:ABCA7) association bp(GO:phagocytosis) |
| pmid:29626319 | p(HGNC:ABCA7) regulates bp(GO:phagocytosis) |
| pmid:29626319 | p(HGNC:ABCA7) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | p(HGNC:ABCA7) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | p(HGNC:ABCA7) decreases p(HGNC:BACE1) |
| pmid:29626319 | p(HGNC:CD33) association bp(GO:phagocytosis) |
| pmid:29626319 | p(HGNC:CD33) decreases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:TREM2, var("p.Arg47His")) decreases act(a(MESH:Microglia)) |
| pmid:29626319 | p(HGNC:TREM2, var("p.Arg47His")) increases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | p(HGNC:SLC2A1) increases p(HGNC:LRP1) |
| pmid:29626319 | p(HGNC:SLC2A1) regulates deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:SLC2A1) regulates tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) |
| pmid:29626319 | p(HGNC:SLC2A1) regulates tloc(a(CHEBI:glucose), fromLoc(GO:"extracellular region"), toLoc(MESH:"Blood-Brain Barrier")) |
| pmid:29626319 | p(HGNC:SLC2A1) regulates a(MESH:"Blood-Brain Barrier") |
| pmid:29626319 | a(HP:"blood-cerebrospinal fluid barrier") decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(MESH:"Choroid Plexus") increases a(MESH:"Cerebrospinal Fluid") |
| pmid:29626319 | p(HGNC:AQP1) increases act(a(MESH:"Choroid Plexus")) |
| pmid:29626319 | p(HGNC:AQP1) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | tloc(a(CHEBI:water), fromLoc(GO:"extracellular region"), toLoc(MESH:"Cerebrospinal Fluid")) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | complex(a(CHEBI:"amyloid-beta"), p(HGNC:TTR)) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(MESH:"Lymph Nodes") decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | complex(a(MESH:Erythrocytes), p(HGNC:CR1)) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | composite(a(CHEBI:"amyloid-beta"), a(MESH:"Serum Albumin")) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(MESH:Aminopeptidases) increases deg(p(HGNC:MAPT)) |
| pmid:29626319 | a(MESH:Thrombin) increases deg(p(HGNC:MAPT)) |
| pmid:29626319 | p(FPLX:CAPN) increases deg(p(HGNC:MAPT)) |
| pmid:29626319 | p(FPLX:CAPN) increases p(HGNC:MAPT, frag("?")) |
| pmid:29626319 | a(MESH:tenuigenin) decreases a(CHEBI:"amyloid-beta polypeptide 40") |
| pmid:29626319 | a(MESH:tenuigenin) increases p(HGNC:PSMD7) |
| pmid:29626319 | bp(GO:"cAMP-mediated signaling") increases p(HGNC:PSMD7) |
| pmid:29626319 | a(CHEBI:rolipram) increases a(CHEBI:"3',5'-cyclic AMP") |
| pmid:29626319 | a(CHEBI:rolipram) increases deg(p(HGNC:MAPT)) |
| pmid:26692334 | a(CHEBI:rolipram) directlyDecreases act(p(FPLX:PDE4)) |
| pmid:26692334 | a(CHEBI:rolipram) positiveCorrelation act(p(FPLX:PKA)) |
| pmid:26692334 | a(CHEBI:rolipram) increases act(complex(GO:"proteasome complex")) |
| pmid:26692334 | a(CHEBI:rolipram) decreases a(HBP:"Tau aggregates") |
| pmid:29626319 | a(CHEBI:wogonin) increases bp(GO:autophagy) |
| pmid:29626319 | a(CHEBI:wogonin) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(CHEBI:wogonin) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29626319 | p(HGNC:PPP2CA) increases bp(GO:autophagy) |
| pmid:10464280 | p(HGNC:PPP2CA) association complex(GO:microtubule) |
| pmid:10464280 | p(HGNC:PPP2CA) increases complex(complex(GO:microtubule), p(HGNC:PPP2CA)) |
| pmid:10464280 | p(HGNC:PPP2CA) isA complex(SCOMP:"PP2A Complex") |
| pmid:29228318 | act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:29062069 | act(p(HGNC:PPP2CA)) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:19401603 | act(p(HGNC:PPP2CA)) positiveCorrelation act(p(HGNC:PIN1)) |
| pmid:19401603 | act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:19401603 | act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 212)) |
| pmid:29626319 | p(HGNC:NPAS4) increases bp(GO:autophagy) |
| pmid:29626319 | p(HGNC:NPAS4) increases deg(p(HGNC:MAPT)) |
| pmid:29626319 | p(HGNC:NPAS4) increases deg(p(HGNC:MAPT, pmod(Ph))) |
| pmid:29626319 | a(CHEBI:statin) increases sec(p(HGNC:IDE)) |
| pmid:29626319 | a(CHEBI:statin) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(CHEBI:"omega-3 fatty acid") increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(CHEBI:"all-cis-5,8,11,14,17-icosapentaenoic acid") increases act(p(HGNC:IDE)) |
| pmid:29626319 | a(CHEBI:"docosahexaenoic acid") increases act(p(HGNC:IDE)) |
| pmid:29626319 | a(CHEBI:"docosahexaenoic acid") increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(CHEBI:"docosahexaenoic acid") increases act(a(MESH:Erythrocytes)) |
| pmid:29626319 | a(CHEBI:atorvastatin) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(CHEBI:atorvastatin) increases sec(p(HGNC:MME)) |
| pmid:29626319 | a(CHEBI:nobiletin) increases act(p(HGNC:MME)) |
| pmid:29626319 | a(CHEBI:nobiletin) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(CHEBI:"ginsenoside Rg1") increases act(p(HGNC:MME)) |
| pmid:29626319 | a(CHEBI:"ginsenoside Rg1") decreases path(MESH:Tauopathies) |
| pmid:29626319 | a(MESH:"Granulocyte Colony-Stimulating Factor") increases act(p(HGNC:MME)) |
| pmid:29626319 | a(MESH:"Granulocyte Colony-Stimulating Factor") decreases path(MESH:Tauopathies) |
| pmid:29626319 | p(HGNC:ANXA1) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | p(HGNC:ANXA1) increases act(p(HGNC:MME)) |
| pmid:29626319 | a(CHEBI:minocycline) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | complex(a(MESH:"Chemokine CX3CL1"), p(HGNC:CX3CR1)) increases deg(a(CHEBI:"amyloid-beta")) |
| pmid:29626319 | a(CHEBI:"disodium cromoglycate") decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(CHEBI:oleocanthal) decreases a(CHEBI:"amyloid-beta") |
| pmid:29626319 | a(CHEBI:oleocanthal) increases p(HGNC:LRP1) |
| pmid:29626319 | a(CHEBI:oleocanthal) increases p(HGNC:ABCB1) |
| pmid:29238289 | p(HBP:"Tau fibrils") increases tloc(p(HGNC:MAPT)) |
| pmid:29238289 | complex(p(HGNC:MAPT), p(MESH:"Receptors, Muscarinic")) increases a(MESH:Calcium) |
| pmid:29238289 | complex(p(HGNC:MAPT), p(MESH:"Receptors, Muscarinic")) decreases a(MESH:Neurons) |
| pmid:29238289 | path(MESH:Starvation) increases p(HGNC:MAPT) |
| pmid:29238289 | complex(p(HGNC:HSPA8), p(INTERPRO:"Chaperone DnaJ")) decreases p(HGNC:MAPT) |
| pmid:29238289 | p(HGNC:SNAP23) increases p(HGNC:MAPT) |
| pmid:29238289 | p(MESH:"SNARE Proteins") increases p(HGNC:MAPT) |
| pmid:29238289 | p(MESH:"rab GTP-Binding Proteins") regulates act(a(MESH:"Transport Vesicles")) |
| pmid:29238289 | p(MESH:"rab GTP-Binding Proteins") regulates bp(MESH:"Membrane Fusion") |
| pmid:29238289 | a(MESH:"Transport Vesicles") association p(HGNC:MAPT) |
| pmid:29238289 | p(HGNC:RAB7A) association p(HGNC:MAPT) |
| pmid:17493042 | a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) |
| pmid:23531502 | a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) |
| pmid:10537045 | a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) |
| pmid:26751493 | a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) |
| pmid:17493042 | a(HBP:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("199_370")) |
| pmid:17493042 | a(HBP:"microtubule-binding region") increases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) |
| pmid:21757739 | a(HBP:"microtubule-binding region") partOf a(HBP:"assembly domain") |
| pmid:21757739 | a(HBP:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("244_369")) |
| pmid:1918161 | a(HBP:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("237_367")) |
| pmid:10537045 | a(HBP:"microtubule-binding region") association act(p(HGNC:TGM2)) |
| pmid:26751493 | a(HBP:"microtubule-binding region") association p(HGNC:HDAC6) |
| pmid:17493042 | p(HBP:"tubulin-binding repeat 2") partOf a(HBP:"microtubule-binding region") |
| pmid:17493042 | p(HBP:"tubulin-binding repeat 2") equivalentTo p(HBP:"Tau isoform F (441 aa)", frag("275_305")) |
| pmid:23407988 | p(HBP:"tubulin-binding repeat 2") partOf p(HBP:"4R tau") |
| pmid:23407988 | p(HBP:"tubulin-binding repeat 2") partOf p(HBP:"3R tau") |
| pmid:2123288 | p(HBP:"tubulin-binding repeat 2") association p(FPLX:CALM) |
| pmid:17493042 | p(HBP:"tubulin-binding repeat 3") partOf a(HBP:"microtubule-binding region") |
| pmid:23531502 | p(HBP:"tubulin-binding repeat 3") partOf a(HBP:"microtubule-binding region") |
| pmid:17493042 | p(HBP:"tubulin-binding repeat 3") equivalentTo p(HBP:"Tau isoform F (441 aa)", frag("306_336")) |
| pmid:23407988 | p(HBP:"tubulin-binding repeat 3") partOf p(HBP:"4R tau") |
| pmid:23407988 | p(HBP:"tubulin-binding repeat 3") partOf p(HBP:"3R tau") |
| pmid:23832849 | p(HBP:"tubulin-binding repeat 3") increases a(HBP:"Tau aggregates") |
| pmid:17493042 | p(HBP:"tubulin-binding repeat 4") partOf a(HBP:"microtubule-binding region") |
| pmid:17493042 | p(HBP:"tubulin-binding repeat 4") equivalentTo p(HBP:"Tau isoform F (441 aa)", frag("337_367")) |
| pmid:17493042 | p(HBP:"tubulin-binding repeat 4") directlyIncreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) |
| pmid:23407988 | p(HBP:"tubulin-binding repeat 4") partOf p(HBP:"4R tau") |
| pmid:17493042 | a(HBP:"projection domain") partOf p(HGNC:MAPT) |
| pmid:26751493 | a(HBP:"projection domain") partOf p(HGNC:MAPT) |
| pmid:17493042 | a(HBP:"projection domain") equivalentTo p(INTERPRO:"MAP2/Tau projection") |
| pmid:17493042 | a(HBP:"projection domain") equivalentTo p(HGNC:MAPT, frag("1_198")) |
| pmid:26751493 | a(HBP:"projection domain") association p(HGNC:LCK) |
| pmid:26751493 | a(HBP:"projection domain") association p(HGNC:FGR) |
| pmid:26751493 | a(HBP:"projection domain") association p(HGNC:SRC) |
| pmid:26751493 | a(HBP:"projection domain") association p(HGNC:GRB2) |
| pmid:26751493 | a(HBP:"projection domain") association p(FPLX:PLC) |
| pmid:26751493 | a(HBP:"projection domain") association a(CHEBI:phosphatidylinositol) |
| pmid:26751493 | a(HBP:"projection domain") association a(CHEBI:"phosphatidylinositol bisphosphate") |
| pmid:26751493 | a(HBP:"projection domain") association p(HGNC:PIN1) |
| pmid:26751493 | a(HBP:"projection domain") association p(HGNC:FYN) |
| pmid:26751493 | a(HBP:"projection domain") association p(HGNC:DLG4) |
| pmid:26751493 | a(HBP:"projection domain") association p(MESH:"Receptors, N-Methyl-D-Aspartate") |
| pmid:17493042 | p(INTERPRO:"MAP2/Tau projection") equivalentTo a(HBP:"projection domain") |
| pmid:8391280 | p(INTERPRO:"MAP2/Tau projection") association p(HGNC:DCTN1) |
| pmid:8391280 | p(INTERPRO:"MAP2/Tau projection") partOf p(HGNC:MAPT) |
| pmid:12551948 | p(INTERPRO:"MAP2/Tau projection") isA p(HGNC:MAPT) |
| pmid:12551948 | p(INTERPRO:"MAP2/Tau projection") decreases bp(GO:"neuron projection development") |
| pmid:12551948 | p(INTERPRO:"MAP2/Tau projection") negativeCorrelation act(complex(GO:"plasma membrane")) |
| pmid:17493042 | p(HBP:"Tau isoform F (441 aa)", frag("244_274")) equivalentTo p(HBP:"tubulin-binding repeat 1") |
| pmid:17493042 | p(HBP:"Tau isoform F (441 aa)", frag("275_305")) equivalentTo p(HBP:"tubulin-binding repeat 2") |
| pmid:17493042 | p(HBP:"Tau isoform F (441 aa)", frag("306_336")) equivalentTo p(HBP:"tubulin-binding repeat 3") |
| pmid:17493042 | p(HBP:"Tau isoform F (441 aa)", frag("337_367")) equivalentTo p(HBP:"tubulin-binding repeat 4") |
| pmid:17493042 | p(HGNC:MAPT, frag("199_370")) equivalentTo a(HBP:"microtubule-binding region") |
| pmid:17493042 | p(HGNC:MAPT, frag("1_198")) equivalentTo a(HBP:"projection domain") |
| pmid:17493042 | p(HBP:"VQIINK motif") partOf p(HBP:"tubulin-binding repeat 2") |
| pmid:17493042 | p(HBP:"VQIINK motif") increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:28002468 | p(HBP:"VQIINK motif") equivalentTo p(HGNC:MAP4, frag("992_999")) |
| pmid:28002468 | p(HBP:"VQIINK motif") equivalentTo p(HGNC:MAP4, frag("1023_1030")) |
| pmid:11606569 | p(HBP:"VQIINK motif") positiveCorrelation p(HGNC:MAPT, var("p.Lys280del")) |
| pmid:11606569 | p(HBP:"VQIINK motif") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pmid:11606569 | p(HBP:"VQIINK motif") increases p(HBP:"Tau aggregates") |
| pmid:17493042 | p(HBP:"VQIVYK motif") partOf p(HBP:"tubulin-binding repeat 3") |
| pmid:23531502 | p(HBP:"VQIVYK motif") partOf p(HBP:"tubulin-binding repeat 3") |
| pmid:17493042 | p(HBP:"VQIVYK motif") increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:23531502 | p(HBP:"VQIVYK motif") increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:19363271 | p(HBP:"VQIVYK motif") association p(SFAM:"HSP90 Family") |
| pmid:19363271 | p(HBP:"VQIVYK motif") isA p(HBP:"tubulin-binding repeat 4") |
| pmid:19363271 | p(HBP:"VQIVYK motif") increases complex(p(HGNC:MAPT), p(SFAM:"HSP90 Family")) |
| pmid:23531502 | p(HBP:"VQIVYK motif") positiveCorrelation p(HBP:"KXGS motif") |
| pmid:28002468 | p(HBP:"VQIVYK motif") equivalentTo p(HGNC:MAP2, frag("332_339")) |
| pmid:11606569 | p(HBP:"VQIVYK motif") positiveCorrelation p(HGNC:MAPT, var("p.Lys280del")) |
| pmid:11606569 | p(HBP:"VQIVYK motif") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pmid:11606569 | p(HBP:"VQIVYK motif") increases p(HBP:"Tau aggregates") |
| pmid:26903089 | p(HBP:"VQIVYK motif") association act(p(HGNC:FKBP4)) |
| pmid:17493042 | p(FPLX:PRKG) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) |
| pmid:17493042 | bp(MESH:Mitosis) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) |
| pmid:21757739 | a(HBP:"assembly domain") equivalentTo p(HGNC:MAPT, frag("199_441")) |
| pmid:21757739 | p(HGNC:MAPT, frag("199_441")) equivalentTo a(HBP:"assembly domain") |
| pmid:21757739 | p(HGNC:MAPT, frag("244_369")) equivalentTo a(HBP:"microtubule-binding region") |
| pmid:21757739 | p(HGNC:MAPT, frag("370_441")) partOf a(HBP:"assembly domain") |
| pmid:21757739 | a(HBP:"proline-rich region 2") equivalentTo p(HGNC:MAPT, frag("199_244")) |
| pmid:21757739 | a(HBP:"proline-rich region 2") partOf a(HBP:"assembly domain") |
| pmid:21757739 | a(HBP:"proline-rich region 2") partOf a(HBP:"proline-rich domain") |
| pmid:21757739 | p(HGNC:MAPT, frag("199_244")) equivalentTo a(HBP:"proline-rich region 2") |
| pmid:21757739 | a(HBP:"proline-rich domain") equivalentTo p(INTERPRO:"PSP, proline-rich") |
| pmid:22033876 | a(HBP:"proline-rich domain") association act(p(FPLX:Actin)) |
| pmid:22033876 | a(HBP:"proline-rich domain") association p(INTERPRO:"SH3 domain") |
| pmid:21757739 | p(INTERPRO:"PSP, proline-rich") equivalentTo a(HBP:"proline-rich domain") |
| pmid:21757739 | a(HBP:"proline-rich region 1") equivalentTo p(HGNC:MAPT, frag("151_198")) |
| pmid:21757739 | a(HBP:"proline-rich region 1") partOf a(HBP:"proline-rich domain") |
| pmid:21757739 | a(HBP:"proline-rich region 1") partOf a(HBP:"projection domain") |
| pmid:21757739 | p(HGNC:MAPT, frag("151_198")) equivalentTo a(HBP:"proline-rich region 1") |
| pmid:21757739 | p(HGNC:MAPT, frag("1_151")) partOf a(HBP:"projection domain") |
| pmid:27260836 | complex(p(HBP:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) positiveCorrelation bp(GO:"clathrin-dependent endocytosis") |
| pmid:27260836 | p(HGNC:AP2M1) partOf p(HBP:"AP-2 complex") |
| pmid:27260836 | p(HGNC:AP2B1) partOf p(HBP:"AP-2 complex") |
| pmid:27260836 | p(HGNC:AP2A1) partOf p(HBP:"AP-2 complex") |
| pmid:27260836 | p(HGNC:AP2A2) partOf p(HBP:"AP-2 complex") |
| pmid:27260836 | p(HGNC:AP2S1) partOf p(HBP:"AP-2 complex") |
| pmid:11943212 | a(HBP:"granulovacuolar degeneration") positiveCorrelation p(HGNC:MARK4, pmod(Ph)) |
| pmid:11943212 | a(HBP:"granulovacuolar degeneration") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:27260836 | complex(GO:"Pick body") positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pmid:26655600 | complex(GO:"Pick body") positiveCorrelation p(HBP:"3R tau") |
| pmid:27260836 | p(HGNC:MAP1LC3B) negativeCorrelation p(HGNC:PICALM) |
| pmid:24368848 | p(HBP:"Tau isoform F (441 aa)", var("p.Pro301Leu")) increases path(MESH:"Frontotemporal Dementia") |
| pmid:23407988 | a(HBP:"ghost tangles") decreases complex(GO:"dendritic tree") |
| pmid:23407988 | a(HBP:"Brodmann (1909) area 36") positiveCorrelation p(HBP:"4R tau") |
| pmid:23407988 | a(HBP:"CA1 field of hippocampus") positiveCorrelation p(HBP:"4R tau") |
| pmid:23407988 | a(HBP:"CA2 field of hippocampus") positiveCorrelation p(HBP:"4R tau") |
| pmid:23407988 | a(HBP:"CA3 field of hippocampus") positiveCorrelation p(HBP:"4R tau") |
| pmid:23407988 | a(HBP:"CA4 field of hippocampus") positiveCorrelation p(HBP:"4R tau") |
| pmid:23407988 | act(complex(GO:dendrite)) positiveCorrelation complex(GO:"dendritic tree") |
| pmid:22253473 | a(MESH:Neuropil) positiveCorrelation p(HBP:"Tau epitope, AT8") |
| pmid:23407988 | complex(GO:"dendritic tree") positiveCorrelation act(complex(GO:dendrite)) |
| pmid:22142809 | p(HBP:RAC1b) association p(HGNC:NGFR) |
| pmid:22142809 | p(HBP:RAC1b) isA p(HGNC:RAC1) |
| pmid:22142809 | p(HBP:RAC1b) negativeCorrelation p(HGNC:CAV2) |
| pmid:22142809 | p(HBP:RAC1b) negativeCorrelation p(HGNC:GNB4) |
| pmid:22142809 | p(HBP:RAC1b) negativeCorrelation p(HGNC:LIPA) |
| pmid:22142809 | p(HBP:RAC1b) positiveCorrelation a(HBP:"cerebral cortex") |
| pmid:27087442 | act(p(HBP:RAC1b)) negativeCorrelation p(MGI:Cdk5) |
| pmid:27087442 | act(p(HBP:RAC1b)) positiveCorrelation act(a(MESH:Neurons)) |
| pmid:27796283 | act(p(HGNC:RAC1)) increases bp(GO:"dendritic spine development") |
| pmid:22142809 | p(HGNC:CAV2) negativeCorrelation p(HBP:RAC1b) |
| pmid:22142809 | p(HGNC:GNB4) negativeCorrelation p(HBP:RAC1b) |
| pmid:22142809 | p(HGNC:LIPA) negativeCorrelation p(HBP:RAC1b) |
| pmid:22142809 | a(HBP:"cerebral cortex") positiveCorrelation p(HBP:RAC1b) |
| pmid:6543144 | complex(GO:microtubule) association p(HGNC:MAPT) |
| pmid:10464280 | complex(GO:microtubule) association p(HGNC:MAPT) |
| pmid:19491104 | complex(GO:microtubule) association p(HGNC:KIF5B) |
| pmid:10464280 | act(complex(GO:microtubule)) positiveCorrelation p(HBP:"microtubule-binding region") |
| pmid:10464280 | complex(GO:microtubule) association p(HGNC:PPP2CA) |
| pmid:10464280 | act(complex(GO:microtubule)) directlyDecreases act(complex(SCOMP:"PP2A Complex")) |
| pmid:18500754 | act(complex(GO:microtubule)) negativeCorrelation act(p(HGNC:HSPA8)) |
| pmid:18500754 | complex(GO:microtubule) association p(INTERPRO:"Heat shock protein 70 family") |
| pmid:20133804 | complex(GO:microtubule) positiveCorrelation bp(GO:"microtubule polymerization") |
| pmid:1918161 | p(HGNC:MAPT, frag("237_367")) directlyIncreases complex(GO:microtubule) |
| pmid:1918161 | p(HGNC:MAPT, frag("237_367")) partOf p(HGNC:MAPT) |
| pmid:1918161 | p(HGNC:MAPT, frag("237_367")) equivalentTo a(HBP:"microtubule-binding region") |
| pmid:1918161 | complex(GO:axon) positiveCorrelation p(HGNC:MAPT) |
| pmid:26671985 | act(complex(GO:axon)) negativeCorrelation a(HBP:neurotoxicity) |
| pmid:1918161 | complex(GO:"neuron projection") positiveCorrelation p(HGNC:MAPT) |
| pmid:17187063 | p(HBP:"Tau isoform F (441 aa)", var("p.Val337Met")) increases a(HBP:Neurodegeneration) |
| pmid:17187063 | a(HBP:Neurodegeneration) positiveCorrelation complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) |
| pmid:19251756 | a(HBP:Neurodegeneration) negativeCorrelation act(p(INTERPRO:"Triosephosphate isomerase")) |
| pmid:22952452 | a(HBP:Neurodegeneration) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:6543144 | complex(GO:neurofilament) association p(HGNC:MAPT) |
| pmid:2446784 | complex(GO:"polysomal ribosome") association p(HGNC:MAPT) |
| pmid:11812770 | p(HGNC:MAPT, frag("1_244")) partOf p(HGNC:MAPT) |
| pmid:11812770 | complex(p(HGNC:GSK3B), p(HGNC:MAPT)) positiveCorrelation p(HGNC:GSK3B) |
| pmid:11812770 | complex(p(HGNC:GSK3B), p(HGNC:MAPT)) positiveCorrelation p(HGNC:MAPT) |
| pmid:18680553 | p(HGNC:MAPT, frag("223_226")) association p(HGNC:FYN) |
| pmid:18680553 | p(HGNC:MAPT, frag("223_226")) partOf p(HGNC:MAPT) |
| pmid:18680553 | bp(GO:myelination) positiveCorrelation complex(p(HGNC:FYN), p(HGNC:MAPT)) |
| pmid:18680553 | bp(GO:myelination) association p(HGNC:MAPT) |
| pmid:18467332 | p(HGNC:SRC, frag("84_145")) association p(HGNC:MAPT) |
| pmid:18467332 | p(HGNC:SRC, frag("84_145")) partOf p(HGNC:SRC) |
| pmid:18467332 | p(HGNC:SRC, frag("84_145")) equivalentTo p(INTERPRO:"SH3 domain") |
| pmid:18467332 | p(INTERPRO:"SH3 domain") equivalentTo p(HGNC:SRC, frag("84_145")) |
| pmid:18467332 | p(INTERPRO:"SH3 domain") equivalentTo p(HGNC:PLCG1, frag("790_851")) |
| pmid:22033876 | p(INTERPRO:"SH3 domain") association a(HBP:"proline-rich domain") |
| pmid:18467332 | p(HGNC:PLCG1, frag("790_851")) association p(HGNC:MAPT) |
| pmid:18467332 | p(HGNC:PLCG1, frag("790_851")) partOf p(HGNC:PLCG1) |
| pmid:18467332 | p(HGNC:PLCG1, frag("790_851")) equivalentTo p(INTERPRO:"SH3 domain") |
| pmid:18467332 | p(HGNC:GRB2, frag("1_57")) association p(HGNC:MAPT) |
| pmid:18467332 | p(HGNC:GRB2, frag("1_57")) isA complex(p(HGNC:GRB2), p(HGNC:MAPT)) |
| pmid:18467332 | p(HGNC:GRB2, frag("1_57")) partOf p(HGNC:GRB2) |
| pmid:18467332 | p(HGNC:GRB2, frag("1_57")) equivalentTo p(INTERPRO:"GRB2, N-terminal SH3 domain") |
| pmid:18467332 | complex(p(HGNC:GRB2), p(HGNC:MAPT)) association p(HGNC:MAPT) |
| pmid:18467332 | p(INTERPRO:"GRB2, N-terminal SH3 domain") equivalentTo p(HGNC:GRB2, frag("1_57")) |
| pmid:18467332 | p(INTERPRO:"GRB2, N-terminal SH3 domain") equivalentTo p(HGNC:PIK3R1, frag("3_79")) |
| pmid:18467332 | p(HGNC:PIK3R1, frag("3_79")) association p(HGNC:MAPT) |
| pmid:18467332 | p(HGNC:PIK3R1, frag("3_79")) partOf p(HGNC:PIK3R1) |
| pmid:18467332 | p(HGNC:PIK3R1, frag("3_79")) equivalentTo p(INTERPRO:"GRB2, N-terminal SH3 domain") |
| pmid:18467332 | p(HGNC:PIK3R1) isA complex(p(HGNC:MAPT), p(HGNC:PIK3R1)) |
| pmid:19491104 | act(complex(GO:"kinesin complex")) positiveCorrelation act(p(HGNC:MAPK8IP1)) |
| pmid:19491104 | act(complex(GO:"kinesin complex")) positiveCorrelation act(p(HGNC:KLC1)) |
| pmid:19491104 | act(complex(GO:"kinesin complex")) positiveCorrelation bp(GO:"vesicle-mediated transport") |
| pmid:19491104 | bp(GO:"vesicle-mediated transport") positiveCorrelation act(complex(GO:"kinesin complex")) |
| pmid:19491104 | p(MGI:Mapk8ip1) association p(MGI:Mapt, pmod(Ph)) |
| pmid:19491104 | act(p(MGI:Mapk8ip1)) negativeCorrelation p(MGI:Mapt, pmod(Ph)) |
| pmid:19491104 | act(p(MGI:Klc1)) negativeCorrelation p(MGI:Mapt, pmod(Ph)) |
| pmid:10464280 | act(complex(SCOMP:"PP2A Complex")) association p(HBP:"microtubule-binding region") |
| pmid:10464280 | act(complex(SCOMP:"PP2A Complex")) increases rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) |
| pmid:10464280 | rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:18500754 | p(INTERPRO:"Heat shock protein 70kD, C-terminal domain superfamily") association p(HBP:"microtubule-binding region") |
| pmid:19363271 | p(SFAM:"HSP90 Family") association p(HBP:"VQIVYK motif") |
| pmid:19363271 | p(SFAM:"HSP90 Family") increases complex(p(HGNC:MAPT), p(SFAM:"HSP90 Family")) |
| pmid:19363271 | p(SFAM:"HSP90 Family") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:19363271 | p(SFAM:"HSP90 Family") positiveCorrelation bp(GO:"neurofibrillary tangle assembly") |
| pmid:20133804 | p(SFAM:"HSP90 Family") association p(HGNC:FKBP4, frag("270_386")) |
| pmid:21367866 | act(p(SFAM:"HSP90 Family")) positiveCorrelation p(HGNC:CDC37) |
| pmid:21367866 | act(p(SFAM:"HSP90 Family")) negativeCorrelation deg(p(HGNC:MAPT)) |
| pmid:20071522 | complex(p(HGNC:MAPT), p(SFAM:"HSP90 Family")) positiveCorrelation p(HGNC:FKBP5) |
| pmid:19363271 | a(CHEBI:juglone) increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:14612456 | complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) directlyIncreases p(HGNC:MAPT, pmod(Ub)) |
| pmid:8391280 | p(FPLX:Ubiquitin) association p(HBP:"microtubule-binding region") |
| pmid:8391280 | p(FPLX:Ubiquitin) directlyIncreases p(HGNC:MAPT, pmod(Ub)) |
| pmid:8391280 | p(HGNC:DCTN1) association p(INTERPRO:"MAP2/Tau projection") |
| pmid:8391280 | p(HGNC:DCTN1) isA complex(p(HGNC:DCTN1), p(HGNC:MAPT)) |
| pmid:8391280 | p(HGNC:DCTN1) isA p(INTERPRO:"Dynein associated protein") |
| pmid:8391280 | complex(p(HGNC:DCTN1), p(HGNC:MAPT)) isA p(INTERPRO:"Dynein associated protein") |
| pmid:8391280 | complex(p(HGNC:DCTN1), p(HGNC:MAPT)) negativeCorrelation g(DBSNP:rs63750424) |
| pmid:8391280 | act(p(INTERPRO:"Dynein associated protein")) positiveCorrelation complex(a(MESH:Microtubules), p(INTERPRO:"Dynein associated protein")) |
| pmid:8391280 | complex(a(MESH:Microtubules), p(INTERPRO:"Dynein associated protein")) positiveCorrelation act(p(INTERPRO:"Dynein associated protein")) |
| pmid:8391280 | g(DBSNP:rs63750424) positiveCorrelation path(MESH:"Frontotemporal Dementia") |
| pmid:8391280 | g(DBSNP:rs63750424) negativeCorrelation complex(p(HGNC:DCTN1), p(HGNC:MAPT)) |
| pmid:16176937 | p(RGD:Klc1) isA complex(p(RGD:Klc1), p(RGD:Mapt)) |
| pmid:16176937 | p(RGD:Klc1) isA p(INTERPRO:"Kinesin motor domain") |
| pmid:16176937 | p(RGD:Klc2) isA complex(p(RGD:Klc2), p(RGD:Mapt)) |
| pmid:16176937 | p(RGD:Klc2) isA p(INTERPRO:"Kinesin motor domain") |
| pmid:16176937 | p(INTERPRO:"Kinesin motor domain") association p(RGD:Snca) |
| pmid:16176937 | p(RGD:Snca) isA complex(p(FPLX:"Cytoplasmic_dynein"), p(RGD:Snca)) |
| pmid:16176937 | p(RGD:Snca) association p(INTERPRO:"Kinesin motor domain") |
| pmid:16176937 | p(FPLX:"Cytoplasmic_dynein") isA complex(p(FPLX:"Cytoplasmic_dynein"), p(RGD:Snca)) |
| pmid:10391244 | p(HGNC:PIN1, frag("5_39")) association p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:10391244 | act(p(HGNC:PIN1, frag("5_39"))) positiveCorrelation complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) |
| pmid:10391244 | complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) positiveCorrelation act(p(HGNC:PIN1, frag("5_39"))) |
| pmid:10391244 | complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) association complex(GO:"neurofibrillary tangle") |
| pmid:10391244 | complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) increases act(p(HGNC:MAPT)) |
| pmid:10391244 | p(HGNC:PIN1, var("p.Tyr23Ala")) decreases act(p(HGNC:PIN1, frag("5_39"))) |
| pmid:20133804 | p(RGD:Fkbp4) positiveCorrelation p(RGD:Mapt, pmod(Ph)) |
| pmid:20133804 | p(RGD:Fkbp4) isA complex(p(RGD:Fkbp4), p(RGD:Mapt, pmod(Ph))) |
| pmid:20133804 | p(RGD:Fkbp4) decreases act(p(RGD:Mapt)) |
| pmid:20133804 | p(RGD:Fkbp4) negativeCorrelation bp(GO:"neuron projection development") |
| pmid:20133804 | bp(GO:"microtubule polymerization") positiveCorrelation complex(GO:microtubule) |
| pmid:19459590 | bp(GO:"microtubule polymerization") positiveCorrelation act(p(HGNC:MAPT)) |
| pmid:20133804 | bp(GO:"neuron projection development") negativeCorrelation p(RGD:Fkbp4) |
| pmid:20133804 | p(HGNC:FKBP4, frag("270_386")) association p(SFAM:"HSP90 Family") |
| pmid:20133804 | p(HGNC:FKBP4, frag("270_386")) isA p(HGNC:FKBP4) |
| pmid:20133804 | p(HGNC:FKBP4, frag("270_386")) isA complex(p(HGNC:FKBP4), p(SFAM:"HSP90 Family")) |
| pmid:20071522 | complex(p(HGNC:AHSA1), p(HGNC:MAPT)) negativeCorrelation p(HGNC:FKBP5) |
| pmid:21367866 | complex(p(HGNC:CDC37), p(SFAM:"HSP90 Family")) positiveCorrelation act(p(HGNC:AKT1), ma(kin)) |
| pmid:2123288 | p(FPLX:CALM) association p(HBP:"tubulin-binding repeat 2") |
| pmid:2123288 | act(p(FPLX:CALM)) increases complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM)) |
| pmid:2123288 | act(p(FPLX:CALM)) decreases bp(GO:"microtubule polymerization") |
| pmid:27133022 | act(p(FPLX:CALM)) positiveCorrelation p(HBP:"DAPK, basic loop (BL) motif") |
| pmid:27133022 | act(p(FPLX:CALM)) increases act(p(HGNC:DAPK2)) |
| pmid:2123288 | complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM)) isA complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) |
| pmid:2123288 | complex(p(FPLX:CALM), p(HGNC:MAPT)) isA complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) |
| pmid:2123288 | complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) negativeCorrelation act(p(HGNC:MAPT)) |
| pmid:2833519 | p(HGNC:S100B) association p(HGNC:MAPT) |
| pmid:2833519 | p(HGNC:S100B) isA complex(p(HGNC:MAPT), p(HGNC:S100B)) |
| pmid:2833519 | act(p(HGNC:S100B)) decreases act(p(SFAM:"CAMK2 Family")) |
| pmid:18494933 | p(HGNC:S100B) increases act(p(HGNC:AGER)) |
| pmid:18494933 | p(HGNC:S100B) directlyIncreases act(p(HGNC:AGER)) |
| pmid:18494933 | p(HGNC:S100B) increases p(FPLX:JNK) |
| pmid:18494933 | p(HGNC:S100B) increases p(FPLX:JNK, pmod(Ph)) |
| pmid:18494933 | p(HGNC:S100B) decreases bp(GO:"Wnt signaling pathway") |
| pmid:18494933 | p(HGNC:S100B) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:2833519 | complex(p(HGNC:MAPT), p(HGNC:S100B)) decreases act(p(SFAM:"CAMK2 Family")) |
| pmid:2833519 | act(p(SFAM:"CAMK2 Family")) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:12714745 | g(DBSNP:rs104893877) positiveCorrelation complex(GO:"neurofibrillary tangle") |
| pmid:12714745 | g(DBSNP:rs104893877) positiveCorrelation complex(GO:"Lewy body") |
| pmid:12714745 | complex(GO:"Lewy body") positiveCorrelation g(DBSNP:rs104893877) |
| pmid:12714745 | composite(p(HGNC:MAPT), p(HGNC:SNCA)) increases complex(GO:"neurofibrillary tangle") |
| pmid:12714745 | composite(p(HGNC:MAPT), p(HGNC:SNCA)) increases complex(GO:"Lewy body") |
| pmid:12551948 | p(HGNC:YWHAZ) isA complex(p(HGNC:GSK3B), p(HGNC:MAPT), p(HGNC:YWHAZ)) |
| pmid:12551948 | p(HGNC:YWHAZ) association p(HGNC:MAPT) |
| pmid:12551948 | p(HGNC:YWHAZ) association p(HGNC:GSK3B) |
| pmid:12551948 | p(HGNC:YWHAZ) increases act(p(HGNC:GSK3B)) |
| pmid:12551948 | act(complex(GO:"plasma membrane")) negativeCorrelation p(INTERPRO:"MAP2/Tau projection") |
| pmid:21339331 | p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:21339331 | p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(Ph, Thr, 212)) |
| pmid:21339331 | p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:21339331 | p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:21339331 | p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Thr, 212)) negativeCorrelation p(FPLX:PKA) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Thr, 212)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 212))) |
| pmid:22072628 | p(HGNC:MAPT, pmod(Ph, Thr, 212)) partOf p(HBP:"proline-rich region 2", pmod(Ph)) |
| pmid:21339331 | p(HGNC:ANXA2) association p(HGNC:MAPT) |
| pmid:21339331 | p(HGNC:ANXA2) association a(MESH:"Cell Membrane") |
| pmid:21339331 | p(HGNC:ANXA2) isA complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) |
| pmid:18096814 | a(CHEBI:"2-bromohexadecanoic acid") decreases p(MGI:Fyn, pmod(Palm)) |
| pmid:18096814 | a(CHEBI:"2-bromohexadecanoic acid") negativeCorrelation p(MGI:Mapt) |
| pmid:18096814 | a(CHEBI:"2-bromohexadecanoic acid") negativeCorrelation p(MGI:Fyn) |
| pmid:18096814 | p(MGI:Fyn, pmod(Palm)) increases tloc(p(MGI:Fyn), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) |
| pmid:21131359 | bp(MESH:"Hot Temperature") increases complex(a(CHEBI:"double-stranded DNA"), p(HGNC:MAPT)) |
| pmid:21131359 | bp(MESH:"Hot Temperature") increases tloc(p(HGNC:MAPT), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) |
| pmid:21131359 | bp(MESH:"Hot Temperature") negativeCorrelation p(HGNC:MAPT) |
| pmid:21131359 | bp(MESH:"Hot Temperature") decreases a(CHEBI:"double-stranded DNA") |
| pmid:8226987 | bp(MESH:"Hot Temperature") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:19732809 | bp(MESH:"Hot Temperature") association a(HBP:"O-GlcNAcylation") |
| pmid:21131359 | a(CHEBI:"double-stranded DNA") association p(HGNC:MAPT) |
| pmid:21131359 | a(CHEBI:"double-stranded DNA") isA complex(a(CHEBI:"double-stranded DNA"), p(HGNC:MAPT)) |
| pmid:8985176 | a(CHEBI:"transfer RNA") increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation act(complex(GO:mitochondrion)) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation complex(GO:mitochondrion) |
| pmid:28173111 | r(MGI:Dnm1l) positiveCorrelation p(MGI:Mapt, pmod(Ph)) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation bp(MESH:"Mitochondrial Dynamics") |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation act(complex(GO:"neuron to neuron synapse")) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Syp) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Dlg4) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Syn1) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Syn2) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Synpo2) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Nrgn) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Gap43) |
| pmid:28173111 | r(MGI:Dnm1l) positiveCorrelation r(MGI:Fis1) |
| pmid:28173111 | r(MGI:Dnm1l) positiveCorrelation p(MGI:Fis1) |
| pmid:28173111 | r(MGI:Dnm1l) positiveCorrelation r(MGI:Ppid) |
| pmid:28173111 | r(MGI:Dnm1l) positiveCorrelation p(MGI:Ppid) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Mfn1) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation p(MGI:Mfn1) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Mfn2) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation p(MGI:Mfn2) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Opa1) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation p(MGI:Opa1) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Nrf1) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation p(MGI:Nrf1) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Nfe2l2) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation p(MGI:Nfe2l2) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Ppargc1a) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation p(MGI:Ppargc1a) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation r(MGI:Tfam) |
| pmid:28173111 | r(MGI:Dnm1l) negativeCorrelation p(MGI:Tfam) |
| pmid:28173111 | act(complex(GO:mitochondrion)) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | complex(GO:mitochondrion) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | complex(GO:mitochondrion) positiveCorrelation p(MGI:Nrf1) |
| pmid:28173111 | complex(GO:mitochondrion) positiveCorrelation p(MGI:Nfe2l2) |
| pmid:28173111 | complex(GO:mitochondrion) positiveCorrelation p(MGI:Ppargc1a) |
| pmid:28173111 | bp(MESH:"Mitochondrial Dynamics") negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | act(complex(GO:"neuron to neuron synapse")) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Syp) |
| pmid:28173111 | act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Dlg4) |
| pmid:28173111 | act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Syn1) |
| pmid:28173111 | act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Syn2) |
| pmid:28173111 | act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") |
| pmid:28173111 | act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Synpo2) |
| pmid:28173111 | act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Nrgn) |
| pmid:28173111 | act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Gap43) |
| pmid:28173111 | r(MGI:Syp) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | r(MGI:Syp) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) |
| pmid:28173111 | r(MGI:Dlg4) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | r(MGI:Dlg4) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) |
| pmid:28173111 | r(MGI:Syn1) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | r(MGI:Syn1) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) |
| pmid:28173111 | r(MGI:Syn2) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | r(MGI:Syn2) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) |
| pmid:28173111 | r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") positiveCorrelation act(complex(GO:"neuron to neuron synapse")) |
| pmid:28173111 | r(MGI:Synpo2) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | r(MGI:Synpo2) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) |
| pmid:28173111 | r(MGI:Nrgn) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | r(MGI:Nrgn) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) |
| pmid:28173111 | r(MGI:Gap43) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | r(MGI:Gap43) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) |
| pmid:28173111 | r(MGI:Fis1) positiveCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Fis1) positiveCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Fis1) positiveCorrelation bp(GO:"mitochondrial fission") |
| pmid:28173111 | bp(GO:"mitochondrial fission") positiveCorrelation p(MGI:Fis1) |
| pmid:28173111 | bp(GO:"mitochondrial fission") positiveCorrelation p(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Dnm1l) positiveCorrelation bp(GO:"mitochondrial fission") |
| pmid:28173111 | r(MGI:Ppid) positiveCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Ppid) positiveCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Ppid) positiveCorrelation complex(GO:"mitochondrial matrix") |
| pmid:28173111 | complex(GO:"mitochondrial matrix") positiveCorrelation p(MGI:Ppid) |
| pmid:28173111 | r(MGI:Mfn1) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Mfn1) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Mfn1) positiveCorrelation bp(GO:"mitochondrial fusion") |
| pmid:28173111 | r(MGI:Mfn2) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Mfn2) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Mfn2) positiveCorrelation bp(GO:"mitochondrial fusion") |
| pmid:28173111 | r(MGI:Opa1) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Opa1) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Opa1) positiveCorrelation bp(GO:"mitochondrial fusion") |
| pmid:28173111 | bp(GO:"mitochondrial fusion") positiveCorrelation p(MGI:Mfn1) |
| pmid:28173111 | bp(GO:"mitochondrial fusion") positiveCorrelation p(MGI:Mfn2) |
| pmid:28173111 | bp(GO:"mitochondrial fusion") positiveCorrelation p(MGI:Opa1) |
| pmid:28173111 | r(MGI:Nrf1) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Nrf1) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Nrf1) positiveCorrelation complex(GO:mitochondrion) |
| pmid:28173111 | r(MGI:Nfe2l2) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Nfe2l2) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Nfe2l2) positiveCorrelation complex(GO:mitochondrion) |
| pmid:28173111 | r(MGI:Ppargc1a) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Ppargc1a) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Ppargc1a) positiveCorrelation complex(GO:mitochondrion) |
| pmid:25987199 | act(p(MGI:Ppargc1a)) positiveCorrelation act(a(GO:mitochondrion)) |
| pmid:28173111 | r(MGI:Tfam) negativeCorrelation r(MGI:Dnm1l) |
| pmid:28173111 | p(MGI:Tfam) negativeCorrelation r(MGI:Dnm1l) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Asp13*")) partOf a(GO:"neurofibrillary tangle") |
| pmid:25974414 | p(HGNC:MAPT, var("p.Asp13*")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25974414 | p(HGNC:MAPT, var("p.Asp13*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Asp25*")) partOf a(GO:"neurofibrillary tangle") |
| pmid:25974414 | p(HGNC:MAPT, var("p.Asp25*")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25974414 | p(HGNC:MAPT, var("p.Asp368*")) partOf a(GO:"neurofibrillary tangle") |
| pmid:25974414 | p(HGNC:MAPT, var("p.Asp368*")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:25974414 | p(HGNC:MAPT, var("p.Asp421*")) partOf a(GO:"neurofibrillary tangle") |
| pmid:25974414 | p(HGNC:MAPT, var("p.Asp421*")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26671985 | p(HGNC:MAPT, var("p.Asp421*")) biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy") |
| pmid:26671985 | p(HGNC:MAPT, var("p.Asp421*")) positiveCorrelation p(HBP:neurotoxicity) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Ala2*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, pmod(HBP:polyamination, Gln, 6)) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Ala103*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Gln124*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Gln124*")) increases p(FPLX:Tubulin, pmod(Ac)) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Gln124*")) increases p(INTERPRO:"Alpha tubulin", pmod(HBP:detyrosination)) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Gln124*")) positiveCorrelation act(p(HGNC:VASH1)) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Gln124*")) positiveCorrelation act(p(HGNC:VASH2)) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Met127*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Pro172*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Lys174*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Lys224*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Ser238*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Lys240*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Lys259*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Gly261*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Val306*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Ile308*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Val309*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Lys311*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Lys331*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Lys395*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Met11*")) isA p(HGNC:MAPT) |
| pmid:25974414 | p(HGNC:MAPT, var("p.Glu12*")) isA p(HGNC:MAPT) |
| pmid:24844691 | p(FPLX:Tubulin, pmod(Ac)) negativeCorrelation act(p(HGNC:HDAC6)) |
| pmid:25974414 | act(p(HGNC:VASH1)) positiveCorrelation p(HGNC:MAPT, var("p.Gln124*")) |
| pmid:25974414 | act(p(HGNC:VASH1)) increases p(INTERPRO:"Alpha tubulin", pmod(HBP:detyrosination)) |
| pmid:25974414 | act(p(HGNC:VASH2)) positiveCorrelation p(HGNC:MAPT, var("p.Gln124*")) |
| pmid:25974414 | act(p(HGNC:VASH2)) increases p(INTERPRO:"Alpha tubulin", pmod(HBP:detyrosination)) |
| pmid:25974414 | act(p(HGNC:TAOK1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 17)) |
| pmid:25974414 | p(HGNC:MAPT, pmod(Ph, Thr, 17)) isA p(HGNC:MAPT) |
| pmid:25974414 | act(p(HGNC:TAOK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 17)) |
| pmid:25974414 | act(p(HGNC:CSNK1A1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 17)) |
| pmid:25673844 | p(HGNC:CSNK1A1) isA p(FPLX:CSNK1) |
| pmid:25546293 | p(HGNC:CSNK1A1) increases p(HGNC:CTNNB1, pmod(Ph, Ser, 35)) |
| pmid:16566606 | a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration)) |
| pmid:21210655 | a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:formylation, Lys)) |
| pmid:16816118 | a(CHEBI:peroxynitrite) increases p(RGD:Mapt, pmod(Ph)) |
| pmid:16816118 | a(CHEBI:peroxynitrite) increases p(RGD:Mapt, pmod(HBP:nitration)) |
| pmid:16816118 | a(CHEBI:peroxynitrite) increases act(p(RGD:Gsk3b)) |
| pmid:16816118 | a(CHEBI:peroxynitrite) increases act(p(RGD:Mapk14)) |
| pmid:16816118 | a(CHEBI:peroxynitrite) increases act(p(RGD:Mapk11)) |
| pmid:16816118 | a(CHEBI:peroxynitrite) increases act(p(RGD:Mapk13)) |
| pmid:16816118 | a(CHEBI:peroxynitrite) causesNoChange act(p(RGD:Mapk12)) |
| pmid:16816118 | a(CHEBI:peroxynitrite) causesNoChange act(p(FPLX:ERK)) |
| pmid:16816118 | a(CHEBI:peroxynitrite) causesNoChange act(p(FPLX:JNK)) |
| pmid:16816118 | a(CHEBI:peroxynitrite) increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:16566606 | a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) |
| pmid:16566606 | a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) |
| pmid:16566606 | a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) |
| pmid:16566606 | a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) |
| pmid:27314526 | a(CHEBI:peroxynitrite) increases bp(GO:"DNA conformation change") |
| pmid:27314526 | a(CHEBI:peroxynitrite) decreases bp(GO:"energy reserve metabolic process") |
| pmid:16566606 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) decreases bp(GO:"tubulin complex assembly") |
| pmid:22057784 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pmid:18562203 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) association act(a(BRCO:Astrocyte)) |
| pmid:18562203 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pmid:17050703 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) isA p(HGNC:MAPT, pmod(HBP:nitration)) |
| pmid:16566606 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation a(HBP:"paired helical filaments") |
| pmid:16566606 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) negativeCorrelation act(p(HGNC:MAPT)) |
| pmid:16566606 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) decreases bp(GO:"tubulin complex assembly") |
| pmid:22057784 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pmid:17050703 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:17050703 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation bp(GO:"neurofibrillary tangle assembly") |
| pmid:17050703 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) partOf a(GO:"neurofibrillary tangle") |
| pmid:17050703 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) partOf path(MESH:"Plaque, Amyloid") |
| pmid:17050703 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) association path(HBP:"Corticobasal Degeneration") |
| pmid:17050703 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) association path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:17050703 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) isA p(HGNC:MAPT, pmod(HBP:nitration)) |
| pmid:16566606 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation a(HBP:"paired helical filaments") |
| pmid:16566606 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) negativeCorrelation act(p(HGNC:MAPT)) |
| pmid:16566606 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) decreases bp(GO:"tubulin complex assembly") |
| pmid:22057784 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:22057784 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) positiveCorrelation path(HBP:"Corticobasal Degeneration") |
| pmid:22057784 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) partOf a(MESH:"Neuropil Threads") |
| pmid:17050703 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) isA p(HGNC:MAPT, pmod(HBP:nitration)) |
| pmid:16566606 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) positiveCorrelation a(HBP:"paired helical filaments") |
| pmid:16566606 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) negativeCorrelation act(p(HGNC:MAPT)) |
| pmid:16566606 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) decreases bp(GO:"tubulin complex assembly") |
| pmid:16566606 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) positiveCorrelation a(HBP:"paired helical filaments") |
| pmid:16566606 | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) negativeCorrelation act(p(HGNC:MAPT)) |
| pmid:26671985 | a(HBP:neurotoxicity) negativeCorrelation act(complex(GO:axon)) |
| pmid:26671985 | p(HBP:"phosphatase-activating domain") positiveCorrelation act(a(HBP:"Tau oligomers")) |
| pmid:26671985 | p(HBP:"phosphatase-activating domain") equivalentTo p(HGNC:MAPT, frag("2_18")) |
| pmid:26671985 | p(HBP:"phosphatase-activating domain") decreases act(complex(GO:axon)) |
| pmid:26671985 | p(HBP:"phosphatase-activating domain") biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy") |
| pmid:26671985 | p(HBP:"phosphatase-activating domain") decreases bp(GO:"axonal transport") |
| pmid:27260838 | p(HBP:"phosphatase-activating domain") association p(HBP:"Tau antibody, TNT1") |
| pmid:27260838 | p(HBP:"phosphatase-activating domain") association p(HBP:"Tau antibody, TNT2") |
| pmid:27260838 | p(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:pretangles) |
| pmid:27574109 | p(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"4R tau") |
| pmid:27373205 | p(HBP:"phosphatase-activating domain") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:21734277 | p(HBP:"phosphatase-activating domain") directlyIncreases act(p(HGNC:PPP1CA)) |
| pmid:26671985 | p(HBP:neurotoxicity) positiveCorrelation p(HGNC:MAPT, var("p.Asp421*")) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me2, Lys, 311)) association p(HGNC:MAPT) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 259)) association p(HGNC:MAPT) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 259)) isA p(HGNC:MAPT, pmod(Me, Lys)) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 290)) association p(HGNC:MAPT) |
| pmid:22033876 | p(HGNC:MAPT, pmod(Me, Lys, 290)) association p(HGNC:MAPT) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 290)) isA p(HGNC:MAPT, pmod(Me, Lys)) |
| pmid:22033876 | p(HGNC:MAPT, pmod(Me, Lys, 290)) partOf p(HBP:"tubulin-binding repeat 2") |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 353)) association p(HGNC:MAPT) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 353)) isA p(HGNC:MAPT, pmod(Me, Lys)) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 24)) association p(HGNC:MAPT) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 24)) isA p(HGNC:MAPT, pmod(Me, Lys)) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 44)) association p(HGNC:MAPT) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 44)) isA p(HGNC:MAPT, pmod(Me, Lys)) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 67)) association p(HGNC:MAPT) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 67)) isA p(HGNC:MAPT, pmod(Me, Lys)) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 190)) association p(HGNC:MAPT) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys, 190)) isA p(HGNC:MAPT, pmod(Me, Lys)) |
| pmid:24869773 | p(HGNC:MAPT, pmod(Me, Lys)) decreases a(HBP:"Tau aggregates") |
| pmid:22033876 | p(HGNC:MAPT, pmod(Me, Lys, 163)) association p(HGNC:MAPT) |
| pmid:22033876 | p(HGNC:MAPT, pmod(Me, Lys, 163)) partOf a(HBP:"proline-rich domain") |
| pmid:22033876 | p(HGNC:MAPT, pmod(Me, Lys, 174)) association p(HGNC:MAPT) |
| pmid:22033876 | p(HGNC:MAPT, pmod(Me, Lys, 174)) partOf a(HBP:"proline-rich domain") |
| pmid:22033876 | p(HGNC:MAPT, pmod(Me, Lys, 180)) association p(HGNC:MAPT) |
| pmid:22033876 | p(HGNC:MAPT, pmod(Me, Lys, 180)) partOf a(HBP:"proline-rich domain") |
| pmid:22033876 | act(p(FPLX:Actin)) association a(HBP:"proline-rich domain") |
| pmid:22033876 | p(HGNC:MAPT, pmod(Me, Lys, 254)) association p(HGNC:MAPT) |
| pmid:22033876 | p(HGNC:MAPT, pmod(Me, Lys, 254)) partOf p(HBP:"tubulin-binding repeat 1") |
| pmid:22033876 | p(HGNC:MAPT, pmod(Ub, Lys, 254)) association p(HGNC:MAPT) |
| pmid:8391280 | p(HGNC:MAPT, pmod(Ub, Lys, 254)) positiveCorrelation a(HBP:"paired helical filaments") |
| pmid:22033876 | p(HGNC:MAPT, pmod(Me, Lys, 267)) association p(HGNC:MAPT) |
| pmid:22033876 | p(HGNC:MAPT, pmod(Me, Lys, 267)) partOf p(HBP:"tubulin-binding repeat 1") |
| pmid:23943618 | p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) |
| pmid:29281045 | p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) |
| pmid:23943618 | p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases act(p(FPLX:PPP2)) |
| pmid:23943618 | act(p(FPLX:PPP2)) positiveCorrelation complex(p(FPLX:PPP2), p(HGNC:MAPT)) |
| pmid:27068745 | act(p(FPLX:PPP2), ma(kin)) positiveCorrelation p(HGNC:UNC5B) |
| pmid:27068745 | act(p(FPLX:PPP2), ma(kin)) increases act(p(HGNC:DAPK1)) |
| pmid:23943618 | complex(p(FPLX:PPP2), p(HGNC:MAPT)) positiveCorrelation act(p(FPLX:PPP2)) |
| pmid:23943618 | complex(p(FPLX:PPP2), p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:22764226 | act(a(CHEBI:"L-dopa")) decreases p(HGNC:PPP2CA, pmod(Me)) |
| pmid:22764226 | act(a(CHEBI:"L-dopa")) decreases p(HGNC:PPP2CA, pmod(Me)) |
| pmid:22764226 | act(a(CHEBI:"L-dopa")) increases a(HBP:"Tau epitope, PHF1") |
| pmid:22764226 | act(a(CHEBI:"L-dopa")) negativeCorrelation a(CHEBI:"folate(2-)") |
| pmid:22764226 | act(a(CHEBI:"L-dopa")) negativeCorrelation a(CHEBI:"folate(2-)") |
| pmid:22764226 | act(a(CHEBI:"L-dopa")) increases a(CHEBI:homocysteine) |
| pmid:22764226 | act(a(CHEBI:"L-dopa")) decreases p(MGI:Ppp2ca, pmod(Me)) |
| pmid:29228318 | p(HGNC:PPP2CA, pmod(Me)) increases act(p(HGNC:PPP2CA)) |
| pmid:22764226 | a(CHEBI:"folate(2-)") negativeCorrelation act(a(CHEBI:"L-dopa")) |
| pmid:22764226 | a(CHEBI:"folate(2-)") negativeCorrelation act(a(CHEBI:"L-dopa")) |
| pmid:28632203 | a(CHEBI:homocysteine) biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:22764226 | p(MGI:Ppp2ca, pmod(Me)) negativeCorrelation a(HBP:"Tau epitope, PHF1") |
| pmid:25143394 | p(MGI:Ppp2ca) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) |
| pmid:25681682 | bp(MESH:"Body Mass Index") negativeCorrelation p(HGNC:AGER) |
| pmid:25681682 | a(CHEBI:"advanced glycation end-product") directlyIncreases act(p(HGNC:AGER)) |
| pmid:24183963 | a(CHEBI:"advanced glycation end-product") directlyIncreases act(p(HGNC:AGER)) |
| pmid:24183963 | a(CHEBI:"advanced glycation end-product") increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:26095350 | a(CHEBI:"advanced glycation end-product") increases p(MGI:Mapt, pmod(Ph, Ser, 214)) |
| pmid:26095350 | a(CHEBI:"advanced glycation end-product") increases p(MGI:Mapt, pmod(Ph, Ser, 396)) |
| pmid:22798221 | a(CHEBI:"advanced glycation end-product") increases act(p(MGI:Gsk3b), ma(kin)) |
| pmid:22798221 | a(CHEBI:"advanced glycation end-product") increases act(p(MGI:Mapk14), ma(kin)) |
| pmid:8063802 | a(CHEBI:"advanced glycation end-product") decreases act(p(HGNC:MAPT)) |
| pmid:8063802 | a(CHEBI:"advanced glycation end-product") increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:24183963 | p(HGNC:GLP1R) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:24183963 | p(HGNC:GLP1R) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:25987199 | act(p(HGNC:GLP1R)) decreases bp(MESH:"Oxidative Stress") |
| pmid:25987199 | act(p(HGNC:GLP1R)) increases act(a(GO:mitochondrion)) |
| pmid:23531502 | a(CHEBI:cinnamaldehyde) decreases p(HBP:"KXGS motif") |
| pmid:23531502 | a(CHEBI:cinnamaldehyde) decreases bp(GO:"neurofibrillary tangle assembly") |
| pmid:23531502 | a(CHEBI:cinnamaldehyde) causesNoChange bp(GO:"microtubule polymerization") |
| pmid:23531502 | a(CHEBI:cinnamaldehyde) decreases act(a(CHEBI:"hydrogen peroxide")) |
| pmid:23531502 | p(HBP:"KXGS motif") positiveCorrelation p(HBP:"VQIVYK motif") |
| pmid:25031639 | p(HBP:"KXGS motif") increases a(GO:"neurofibrillary tangle") |
| pmid:23531502 | a(CHEBI:"(-)-epicatechin") decreases p(HBP:"KXGS motif") |
| pmid:23531502 | a(CHEBI:"(-)-epicatechin") decreases bp(GO:"neurofibrillary tangle assembly") |
| pmid:23531502 | a(CHEBI:"(-)-epicatechin") decreases act(a(CHEBI:"hydrogen peroxide")) |
| pmid:23531502 | a(CHEBI:"(-)-epicatechin") increases complex(a(CHEBI:"(-)-epicatechin"), a(CHEBI:acrolein)) |
| pmid:23531502 | complex(a(CHEBI:"(-)-epicatechin"), a(CHEBI:acrolein)) decreases act(a(CHEBI:acrolein)) |
| pmid:23531502 | act(a(CHEBI:acrolein)) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:17082178 | a(CHEBI:acrolein) increases a(GO:"neurofibrillary tangle") |
| pmid:23531502 | act(a(CHEBI:acrolein)) positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pmid:23531502 | act(a(CHEBI:acrolein)) decreases a(MESH:Neurons) |
| pmid:23531502 | act(a(CHEBI:acrolein)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26655600 | p(HBP:"Tau isoform F (441 aa)", pmod(HBP:glycation)) increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:26655600 | p(HBP:"Tau isoform F (441 aa)", pmod(HBP:glycation)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(Ph)) |
| pmid:26655600 | p(HBP:"Tau isoform C (410 aa)", pmod(HBP:glycation)) increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:26655600 | p(HBP:"Tau isoform B (381 aa)", pmod(HBP:glycation)) decreases bp(GO:"neurofibrillary tangle assembly") |
| pmid:26655600 | p(HBP:"Tau isoform F (441 aa)", pmod(Ph)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(HBP:glycation)) |
| pmid:26655600 | p(HBP:"Tau isoform D (383 aa)", pmod(HBP:glycation)) decreases bp(GO:"neurofibrillary tangle assembly") |
| pmid:26655600 | p(HBP:"Tau isoform E (412 aa)", pmod(HBP:glycation)) decreases bp(GO:"neurofibrillary tangle assembly") |
| pmid:26655600 | p(HBP:"Tau isoform D (383 aa)", pmod(Ph)) decreases bp(GO:"neurofibrillary tangle assembly") |
| pmid:26655600 | p(HBP:"Tau isoform E (412 aa)", pmod(Ph)) decreases bp(GO:"neurofibrillary tangle assembly") |
| pmid:26655600 | p(HBP:"Tau isoform B (381 aa)", pmod(Ph)) increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:26655600 | p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:glycation)) increases bp(GO:"neurofibrillary tangle assembly") |
| pmid:26304819 | a(CHEBI:glyceraldehyde) decreases bp(GO:"canonical glycolysis") |
| pmid:26304819 | a(CHEBI:glyceraldehyde) increases r(HGNC:GAPDH) |
| pmid:26304819 | a(CHEBI:glyceraldehyde) increases bp(GO:"apoptotic process") |
| pmid:26304819 | a(CHEBI:glyceraldehyde) increases a(HBP:"GA-AGE") |
| pmid:26304819 | a(CHEBI:glyceraldehyde) decreases p(HGNC:APP, frag("672_713")) |
| pmid:26304819 | a(CHEBI:glyceraldehyde) increases p(HGNC:MAPT) |
| pmid:26304819 | a(CHEBI:glyceraldehyde) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:26304819 | a(CHEBI:glyceraldehyde) increases p(HGNC:VEGFA) |
| pmid:26304819 | a(CHEBI:glyceraldehyde) increases p(HGNC:TGFB1) |
| pmid:19251756 | bp(GO:"canonical glycolysis") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26304819 | r(HGNC:GAPDH) association bp(GO:"apoptotic process") |
| pmid:26304819 | a(HBP:"GA-AGE") isA a(CHEBI:"advanced glycation end-product") |
| pmid:26304819 | p(HGNC:VEGFA) biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:26095350 | a(CHEBI:"D-ribose") increases a(CHEBI:"advanced glycation end-product") |
| pmid:26095350 | a(CHEBI:"D-ribose") positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 214)) |
| pmid:26095350 | a(CHEBI:"D-ribose") positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 396)) |
| pmid:26095350 | a(CHEBI:"D-ribose") positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 214), pmod(Ph, Ser, 396)) |
| pmid:26095350 | a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) |
| pmid:28176663 | a(CHEBI:"D-ribose") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 214)) |
| pmid:26095350 | a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:28176663 | a(CHEBI:"D-ribose") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:26095350 | a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:28176663 | a(CHEBI:"D-ribose") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:26095350 | a(CHEBI:"D-ribose") increases p(MGI:Camk2b, pmod(Ph, Thr, 287)) |
| pmid:26095350 | a(CHEBI:"D-ribose") decreases p(MGI:Camk2b, pmod(Ph, Thr, 306)) |
| pmid:19517062 | a(CHEBI:"D-ribose") increases p(HBP:"Tau aggregates") |
| pmid:19517062 | a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(HBP:glycation)) |
| pmid:28176663 | a(CHEBI:"D-ribose") increases a(HBP:"advanced glycation end product") |
| pmid:26095350 | p(MGI:Mapt, pmod(Ph, Ser, 214)) positiveCorrelation a(CHEBI:"D-ribose") |
| pmid:26095350 | p(MGI:Mapt, pmod(Ph, Ser, 396)) positiveCorrelation a(CHEBI:"D-ribose") |
| pmid:28877763 | p(MGI:Mapt, pmod(Ph, Ser, 396)) positiveCorrelation p(MGI:Syk) |
| pmid:25331948 | p(MGI:Mapt, pmod(Ph, Ser, 396)) positiveCorrelation p(MGI:Syk) |
| pmid:26095350 | p(MGI:Mapt, pmod(Ph, Ser, 214), pmod(Ph, Ser, 396)) positiveCorrelation a(CHEBI:"D-ribose") |
| pmid:26095350 | p(MGI:Camk2b, pmod(Ph, Thr, 287)) increases act(p(MGI:Camk2b)) |
| pmid:26095350 | p(MGI:Camk2b, pmod(Ph, Thr, 306)) decreases act(p(MGI:Camk2b)) |
| pmid:22798221 | a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 404)) |
| pmid:22798221 | a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 198)) |
| pmid:22798221 | a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 199)) |
| pmid:22798221 | a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 202)) |
| pmid:22798221 | a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Thr, 231)) |
| pmid:22798221 | a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 396)) |
| pmid:22798221 | a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Thr, 205)) |
| pmid:22798221 | a(CHEBI:methylglyoxal) increases a(CHEBI:"advanced glycation end-product") |
| pmid:22798221 | a(CHEBI:methylglyoxal) increases p(HGNC:AGER) |
| pmid:19251756 | a(CHEBI:methylglyoxal) negativeCorrelation act(p(INTERPRO:"Triosephosphate isomerase")) |
| pmid:17082178 | a(CHEBI:methylglyoxal) increases a(GO:"neurofibrillary tangle") |
| pmid:28877763 | p(MGI:Mapt, pmod(Ph, Ser, 404)) positiveCorrelation p(MGI:Syk) |
| pmid:25331948 | p(MGI:Mapt, pmod(Ph, Ser, 404)) positiveCorrelation p(MGI:Syk) |
| pmid:29221819 | p(MGI:Mapt, pmod(Ph, Ser, 202)) negativeCorrelation p(MGI:Dyrk1a) |
| pmid:25331948 | p(MGI:Mapt, pmod(Ph, Ser, 202)) positiveCorrelation p(MGI:Syk) |
| pmid:22798221 | act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 404)) |
| pmid:22798221 | act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 198)) |
| pmid:22798221 | act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 199)) |
| pmid:22798221 | act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 202)) |
| pmid:22798221 | act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 231)) |
| pmid:22798221 | act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 396)) |
| pmid:22798221 | act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 205)) |
| pmid:19517062 | p(HGNC:MAPT, pmod(HBP:glycation)) increases a(CHEBI:"advanced glycation end-product") |
| pmid:19517062 | p(HGNC:MAPT, pmod(HBP:glycation)) partOf p(HBP:"Tau aggregates") |
| pmid:19251756 | act(p(INTERPRO:"Triosephosphate isomerase")) increases rxn(reactants(a(CHEBI:"dihydroxyacetone phosphate")), products(a(CHEBI:"D-glyceraldehyde 3-phosphate"))) |
| pmid:19251756 | p(INTERPRO:"Triosephosphate isomerase") partOf bp(GO:"canonical glycolysis") |
| pmid:19251756 | act(p(INTERPRO:"Triosephosphate isomerase")) negativeCorrelation a(HBP:Neurodegeneration) |
| pmid:19251756 | act(p(INTERPRO:"Triosephosphate isomerase")) negativeCorrelation a(CHEBI:methylglyoxal) |
| pmid:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) decreases act(p(INTERPRO:"Triosephosphate isomerase")) |
| pmid:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) isA p(INTERPRO:"Triosephosphate isomerase", pmod(NO)) |
| pmid:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) decreases act(p(INTERPRO:"Triosephosphate isomerase")) |
| pmid:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) isA p(INTERPRO:"Triosephosphate isomerase", pmod(NO)) |
| pmid:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(NO)) association p(HGNC:MAPT) |
| pmid:19251756 | p(INTERPRO:"Triosephosphate isomerase", pmod(NO)) partOf complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) |
| pmid:19251756 | complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:19251756 | complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) partOf a(GO:"neurofibrillary tangle") |
| pmid:18494933 | p(FPLX:JNK, pmod(Ph)) positiveCorrelation act(p(FPLX:JNK)) |
| pmid:16630055 | p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:22833681 | p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:22833681 | p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:22833681 | p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:22833681 | p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356)) |
| pmid:22833681 | p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:22833681 | p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) decreases a(HBP:"Tau aggregates") |
| pmid:19732809 | p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:16630055 | path(MESH:Fasting) decreases p(MGI:Mapt, pmod(HBP:"O-GlcNAcylation")) |
| pmid:16630055 | path(MESH:Fasting) increases p(MGI:Mapt, pmod(Ph)) |
| pmid:16630055 | path(MESH:Fasting) negativeCorrelation a(CHEBI:glucose) |
| pmid:12578227 | p(HGNC:TGM1) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:12578227 | p(HGNC:TGM1) isA p(ECCODE:"2.3.2.13") |
| pmid:12578227 | r(HBP:"TGM2 Isoform 3 (349 aa)") isA r(HGNC:TGM2) |
| pmid:12578227 | p(HGNC:TGM2) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:9099822 | act(p(HGNC:TGM2)) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:12578227 | p(HGNC:TGM2) isA p(ECCODE:"2.3.2.13") |
| pmid:10537045 | p(HGNC:TGM2) positiveCorrelation p(HGNC:MAPT) |
| pmid:10537045 | p(HGNC:TGM2) partOf complex(p(HGNC:MAPT), p(HGNC:TGM2)) |
| pmid:10537045 | act(p(HGNC:TGM2)) association a(HBP:"microtubule-binding region") |
| pmid:11089576 | act(p(ECCODE:"2.3.2.13")) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") |
| pmid:11089576 | act(p(ECCODE:"2.3.2.13")) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:11738469 | act(p(ECCODE:"2.3.2.13")) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:8985134 | act(p(ECCODE:"2.3.2.13")) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:11738469 | act(p(ECCODE:"2.3.2.13")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:8985134 | act(p(ECCODE:"2.3.2.13")) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:10537045 | complex(p(HGNC:MAPT), p(HGNC:TGM2)) positiveCorrelation a(CHEBI:"calcium(2+)") |
| pmid:10537045 | a(HBP:maitotoxin) increases a(CHEBI:"calcium(2+)") |
| pmid:10537045 | a(HBP:maitotoxin) increases act(p(HGNC:TGM2)) |
| pmid:22057784 | p(HGNC:MAPT, pmod(NO, Tyr, 29)) positiveCorrelation path(MESH:"Pick Disease of the Brain") |
| pmid:18562203 | act(a(BRCO:Astrocyte)) association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) |
| pmid:17768677 | p(MGI:Mapt, pmod(HBP:nitration, Tyr, 488)) causesNoChange act(p(MGI:Mapt)) |
| pmid:17768677 | p(MGI:Mapt, pmod(HBP:nitration, Tyr, 507)) partOf a(MESH:Brain) |
| pmid:16816118 | a(CHEBI:linsidomine) increases a(CHEBI:peroxynitrite) |
| pmid:16816118 | a(CHEBI:linsidomine) decreases act(p(HBP:"20 S Proteasome")) |
| pmid:16816118 | p(RGD:Mapt, pmod(HBP:nitration)) negativeCorrelation act(p(HBP:"20 S Proteasome")) |
| pmid:27796283 | act(p(HGNC:RHOA)) decreases bp(GO:"dendritic spine development") |
| pmid:27796283 | act(p(HGNC:RHOA)) negativeCorrelation a(MESH:"Dendritic Spines") |
| pmid:27796283 | act(p(HGNC:RHOA)) positiveCorrelation complex(p(HGNC:ARHGEF2), p(HGNC:RHOA)) |
| pmid:27796283 | bp(GO:"dendritic spine development") positiveCorrelation a(MESH:"Dendritic Spines") |
| pmid:27796283 | p(HGNC:TIAM1, pmod(Ph)) increases act(p(HGNC:RAC1)) |
| pmid:27796283 | p(HGNC:CAMK2B) increases p(HBP:"Kalirin 7", pmod(Ph, Thr, 95)) |
| pmid:27796283 | p(HBP:"Kalirin 7", pmod(Ph, Thr, 95)) increases act(p(HBP:"Kalirin 7")) |
| pmid:27796283 | act(p(HBP:"Kalirin 7")) increases act(p(HGNC:RAC1)) |
| pmid:27796283 | p(HGNC:CAMK1) increases p(HGNC:ARHGEF7, pmod(Ph, Ser, 516)) |
| pmid:27796283 | p(HGNC:ARHGEF7, pmod(Ph, Ser, 516)) increases act(p(HGNC:ARHGEF7)) |
| pmid:27796283 | act(p(HGNC:ARHGEF7)) increases act(p(HGNC:RAC1)) |
| pmid:27796283 | complex(GO:"AMPA glutamate receptor complex") decreases act(p(HGNC:ARHGEF2)) |
| pmid:27796283 | act(p(HGNC:ARHGEF2)) regulates a(MESH:"Dendritic Spines") |
| pmid:27796283 | act(p(HGNC:CAMKV)) decreases complex(p(HGNC:ARHGEF2), p(HGNC:RHOA)) |
| pmid:27796283 | act(p(HGNC:CAMKV)) decreases act(p(HGNC:RHOA)) |
| pmid:27796283 | p(HGNC:CAMKV) regulates bp(GO:"neuron-neuron synaptic transmission") |
| pmid:27796283 | p(HGNC:CAMKV) association bp(MESH:"Long-Term Potentiation") |
| pmid:27796283 | complex(p(HGNC:ARHGEF2), p(HGNC:RHOA)) positiveCorrelation act(p(HGNC:RHOA)) |
| pmid:27796283 | p(HGNC:CAMKV, pmod(Ph, Thr, 345)) decreases act(p(HGNC:CAMKV)) |
| pmid:29121589 | p(HGNC:KEAP1) increases complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) |
| pmid:29121589 | p(HGNC:KEAP1) isA p(ECCODE:"2.3.2.27") |
| pmid:29121589 | complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) increases p(HGNC:NFE2L2, pmod(UbPoly)) |
| pmid:29121589 | p(HGNC:CUL3) partOf complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) |
| pmid:29121589 | p(HGNC:NFE2L2, pmod(UbPoly)) increases deg(p(HGNC:NFE2L2)) |
| pmid:29121589 | p(HGNC:NFE2L2, pmod(Ph)) partOf complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph))) |
| pmid:29121589 | p(HGNC:BTRC) increases complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph))) |
| pmid:29121589 | p(HGNC:BTRC) isA p(ECCODE:"2.3.2.27") |
| pmid:29121589 | complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph))) increases p(HGNC:NFE2L2, pmod(UbPoly)) |
| pmid:29121589 | a(CHEBI:"dimethyl fumarate") increases act(p(FPLX:ERK)) |
| pmid:29121589 | a(CHEBI:"dimethyl fumarate") increases act(p(FPLX:p38)) |
| pmid:29121589 | a(CHEBI:"dimethyl fumarate") positiveCorrelation p(FPLX:AKT, pmod(Ph, Ser, 473)) |
| pmid:29121589 | a(CHEBI:"dimethyl fumarate") increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:29121589 | a(CHEBI:"dimethyl fumarate") decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:29121589 | a(CHEBI:"dimethyl fumarate") negativeCorrelation p(HGNC:DPYSL2, pmod(Ph)) |
| pmid:29121589 | a(CHEBI:"dimethyl fumarate") decreases a(HBP:Astrogliosis) |
| pmid:29121589 | a(CHEBI:"dimethyl fumarate") decreases a(HBP:Microgliosis) |
| pmid:29121589 | a(CHEBI:"dimethyl fumarate") decreases r(MGI:Il1b) |
| pmid:29121589 | a(CHEBI:"dimethyl fumarate") decreases r(MGI:Nos2) |
| pmid:29121589 | a(CHEBI:"dimethyl fumarate") decreases bp(GO:"inflammatory response") |
| pmid:29121589 | p(FPLX:AKT, pmod(Ph, Ser, 473)) positiveCorrelation a(CHEBI:"dimethyl fumarate") |
| pmid:29121589 | p(FPLX:AKT, pmod(Ph, Ser, 473)) increases act(p(FPLX:AKT)) |
| pmid:29121589 | p(HGNC:DPYSL2, pmod(Ph)) negativeCorrelation a(CHEBI:"dimethyl fumarate") |
| pmid:24401760 | a(HBP:Astrogliosis) biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:29121589 | r(MGI:Il1b) biomarkerFor bp(GO:"inflammatory response") |
| pmid:29121589 | r(MGI:Nos2) biomarkerFor bp(GO:"inflammatory response") |
| pmid:27807169 | p(RGD:Cdk5r2) directlyIncreases act(p(RGD:Cdk5)) |
| pmid:27807169 | p(RGD:Cdk5r2) positiveCorrelation a(GO:"dendritic spine") |
| pmid:27807169 | p(RGD:Cdk5r2) positiveCorrelation a(GO:synapse) |
| pmid:21489990 | act(p(RGD:Cdk5)) directlyIncreases p(RGD:Mapt, pmod(Ph, Ser, 396)) |
| pmid:21489990 | act(p(RGD:Cdk5)) directlyIncreases p(RGD:Mapt, pmod(Ph, Ser, 404)) |
| pmid:21489990 | act(p(RGD:Cdk5)) directlyDecreases act(p(RGD:Ppp1ca)) |
| pmid:7514173 | a(CHEBI:"glycerol 2-phosphate") decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:7514173 | a(CHEBI:"diethyl pyrocarbonate") decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:7514173 | a(CHEBI:"pyridoxal 5'-phosphate") decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:7514173 | a(CHEBI:Phenylglyoxal) decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:7514173 | a(CHEBI:"poly(lysine) polymer") decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:7514173 | a(CHEBI:"sodium chloride") decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:7514173 | a(CHEBI:"sodium fluoride") decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:7514173 | a(CHEBI:"manganese(II) chloride") decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:7514173 | a(CHEBI:"calcium dichloride") decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Thr, 217)) positiveCorrelation p(FPLX:PKA) |
| pmid:17078951 | p(HGNC:MAPT, pmod(Ph, Thr, 217)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 217))) |
| pmid:22072628 | p(HGNC:MAPT, pmod(Ph, Thr, 217)) partOf p(HBP:"proline-rich region 2", pmod(Ph)) |
| pmid:9089387 | p(FPLX:PDH, pmod(Ph)) negativeCorrelation act(p(FPLX:PDH, pmod(Ph))) |
| pmid:9089387 | act(p(FPLX:PDH, pmod(Ph))) negativeCorrelation p(FPLX:PDH, pmod(Ph)) |
| pmid:22102280 | a(HBP:tideglusib) decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:22102280 | a(CHEBI:hypothemycin) decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:22102280 | a(CHEBI:alsterpaullone) decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:10998059 | a(CHEBI:alsterpaullone) decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:10998059 | a(CHEBI:alsterpaullone) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:10998059 | a(CHEBI:alsterpaullone) decreases act(p(MGI:Cdk5), ma(kin)) |
| pmid:10998059 | a(CHEBI:alsterpaullone) decreases p(MGI:Ppp1r1b, pmod(Ph)) |
| pmid:11013232 | a(HBP:indirubin) decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:10998059 | act(p(MGI:Cdk5), ma(kin)) increases p(MGI:Ppp1r1b, pmod(Ph)) |
| pmid:26400044 | act(p(MGI:Cdk5), ma(kin)) increases p(MGI:Wasf1, pmod(Ph)) |
| pmid:26400044 | act(p(MGI:Cdk5), ma(kin)) increases p(MGI:Dpysl2, pmod(Ph)) |
| pmid:24808823 | p(MGI:Cdk5) negativeCorrelation bp(GO:learning) |
| pmid:27087442 | p(MGI:Cdk5) negativeCorrelation p(MGI:Cdk5r1) |
| pmid:27087442 | p(MGI:Cdk5) negativeCorrelation act(p(HBP:RAC1b)) |
| pmid:27087442 | p(MGI:Cdk5) negativeCorrelation path(MESH:Cognition) |
| pmid:27087442 | p(MGI:Cdk5) negativeCorrelation act(a(MESH:Neurons)) |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 175)) |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 176)) |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 178)) |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 195)) |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 198)) |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(HBP:"Tau epitope, AT8") |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 217)) |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 220)) |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 235)) |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 239)) |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 396)) |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 400)) |
| pmid:14642273 | act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 403)) |
| pmid:8702879 | p(HGNC:SYN1, pmod(Ph, Ser, 551)) negativeCorrelation act(p(HGNC:SYN1)) |
| pmid:8702879 | act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(Ph, Ser, 551)) |
| pmid:8702879 | act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(Ph, Ser, 62)) |
| pmid:8702879 | act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(Ph, Ser, 67)) |
| pmid:8702879 | act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(Ph, Ser, 62)) |
| pmid:8702879 | act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(Ph, Ser, 67)) |
| pmid:8702879 | act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(Ph, Ser, 551)) |
| pmid:8702879 | p(HGNC:SYN1, pmod(Ph, Ser, 62)) negativeCorrelation act(p(HGNC:SYN1)) |
| pmid:8702879 | p(HGNC:SYN1, pmod(Ph, Ser, 67)) negativeCorrelation act(p(HGNC:SYN1)) |
| pmid:26400044 | p(MGI:Wasf1, pmod(Ph)) partOf complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) |
| pmid:26400044 | p(MGI:Dpysl2, pmod(Ph)) partOf complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) |
| pmid:26400044 | complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) association path(MESH:"Plaque, Amyloid") |
| pmid:8726973 | a(HBP:isopentanyladenine) decreases act(p(HGNC:CDK5)) |
| pmid:8726973 | a(HBP:olomoucine) decreases act(p(HGNC:CDK5)) |
| pmid:18239272 | p(HGNC:CSNK1D) increases p(HGNC:MAPT, pmod(Ph)) |
| pmid:25673844 | p(HGNC:CSNK1D) isA p(FPLX:CSNK1) |
| pmid:18239272 | p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 198)) |
| pmid:18239272 | p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:18239272 | p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:18239272 | p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:18239272 | p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:18239272 | p(HGNC:TTBK1) association a(HBP:pretangles) |
| pmid:20096481 | p(HGNC:TTBK1) increases act(p(HGNC:CDK5)) |
| pmid:20096481 | p(HGNC:TTBK1) increases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:21548880 | p(HGNC:TTBK1) increases p(HGNC:CDK5R1) |
| pmid:21548880 | p(HGNC:TTBK1) positiveCorrelation act(p(ECCODE:"3.4.22.52")) |
| pmid:21548880 | p(HGNC:TTBK1) negativeCorrelation p(HGNC:GRIN2B) |
| pmid:21548880 | p(HGNC:TTBK1) negativeCorrelation p(HGNC:GRIN2D) |
| pmid:25673844 | p(HGNC:TTBK1) isA p(HBP:"CK1 superfamily") |
| pmid:25673844 | p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 42)) |
| pmid:25673844 | p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 45)) |
| pmid:25673844 | p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 47)) |
| pmid:25673844 | p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 80)) |
| pmid:25673844 | p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 81)) |
| pmid:25673844 | p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Thr, 84)) |
| pmid:25473830 | p(HGNC:TTBK1) directlyIncreases p(HGNC:TARDBP, pmod(Ph)) |
| pmid:25473830 | p(HGNC:TTBK1) increases tloc(p(HGNC:TARDBP, pmod(Ph)), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) |
| pmid:23687953 | act(p(HGNC:TTBK1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 197)) |
| pmid:20096481 | g(DBSNP:rs2651206) association path(MESH:"Alzheimer Disease") |
| pmid:21548880 | g(DBSNP:rs2651206) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:20096481 | g(DBSNP:rs2651206) association g(HGNC:TTBK1) |
| pmid:21548880 | g(DBSNP:rs2651206) isA g(HGNC:TTBK1) |
| pmid:20096481 | g(DBSNP:rs10807287) association path(MESH:"Alzheimer Disease") |
| pmid:20096481 | g(DBSNP:rs10807287) association g(HGNC:TTBK1) |
| pmid:20096481 | g(DBSNP:rs7764257) association path(MESH:"Alzheimer Disease") |
| pmid:20096481 | g(DBSNP:rs7764257) association g(HGNC:TTBK1) |
| pmid:20096481 | g(HGNC:TTBK1) association g(DBSNP:rs2651206) |
| pmid:20096481 | g(HGNC:TTBK1) association g(DBSNP:rs10807287) |
| pmid:20096481 | g(HGNC:TTBK1) association g(DBSNP:rs7764257) |
| pmid:17620722 | p(HGNC:TTBK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 208)) |
| pmid:17620722 | p(HGNC:TTBK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 210)) |
| pmid:25673844 | p(HGNC:TTBK2) isA p(HBP:"CK1 superfamily") |
| pmid:25673844 | p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 42)) |
| pmid:25673844 | p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 45)) |
| pmid:25673844 | p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 47)) |
| pmid:25673844 | p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 80)) |
| pmid:25673844 | p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 81)) |
| pmid:25673844 | p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Thr, 84)) |
| pmid:25473830 | p(HGNC:TTBK2) directlyIncreases p(HGNC:TARDBP, pmod(Ph)) |
| pmid:25473830 | p(HGNC:TTBK2) increases tloc(p(HGNC:TARDBP, pmod(Ph)), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) |
| pmid:27607061 | p(HGNC:TTBK2) decreases surf(p(HGNC:GRIK2)) |
| pmid:26323690 | p(HGNC:TTBK2) increases p(HGNC:KIF2A, pmod(Ph)) |
| pmid:26323690 | p(HGNC:TTBK2) increases act(p(HGNC:SLC6A12)) |
| pmid:26323690 | p(HGNC:TTBK2) increases act(p(HGNC:SLC5A1)) |
| pmid:26323690 | p(HGNC:TTBK2) association p(HGNC:CEP164) |
| pmid:26323690 | act(p(HGNC:TTBK2)) positiveCorrelation p(HGNC:CEP164) |
| pmid:26323690 | p(HGNC:TTBK2) association p(HGNC:MAPRE1) |
| pmid:26323690 | act(p(HGNC:TTBK2)) decreases p(HGNC:CCP110) |
| pmid:26323690 | act(p(HGNC:TTBK2)) increases p(HGNC:CEP164, pmod(Ph)) |
| pmid:26323690 | act(p(HGNC:TTBK2)) increases p(HGNC:CEP97, pmod(Ph)) |
| pmid:2820993 | act(p(FPLX:CSNK2)) increases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:21548880 | p(HGNC:TTBK2, var("p.Tyr448*")) positiveCorrelation path(HBP:"Spinocerebellar Ataxia 11") |
| pmid:21548880 | p(HGNC:TTBK2, var("p.Tyr448*")) increases p(HGNC:TTBK2) |
| pmid:21548880 | p(HGNC:TTBK2, var("p.Tyr448*")) decreases act(p(HGNC:TTBK2), ma(kin)) |
| pmid:21548880 | path(HBP:"Spinocerebellar Ataxia 11") positiveCorrelation p(HGNC:TTBK2, var("p.Tyr448*")) |
| pmid:21548880 | path(HBP:"Spinocerebellar Ataxia 11") positiveCorrelation p(HGNC:TTBK2, var("p.Asp449*")) |
| pmid:21548880 | path(HBP:"Spinocerebellar Ataxia 11") positiveCorrelation p(HGNC:TTBK2, var("p.Glu450*")) |
| pmid:21548880 | p(HGNC:TTBK2, var("p.Asp449*")) positiveCorrelation path(HBP:"Spinocerebellar Ataxia 11") |
| pmid:21548880 | p(HGNC:TTBK2, var("p.Asp449*")) increases p(HGNC:TTBK2) |
| pmid:21548880 | p(HGNC:TTBK2, var("p.Asp449*")) decreases act(p(HGNC:TTBK2), ma(kin)) |
| pmid:21548880 | p(HGNC:TTBK2, var("p.Glu450*")) positiveCorrelation path(HBP:"Spinocerebellar Ataxia 11") |
| pmid:21548880 | p(HGNC:TTBK2, var("p.Glu450*")) increases p(HGNC:TTBK2) |
| pmid:21548880 | p(HGNC:TTBK2, var("p.Glu450*")) decreases act(p(HGNC:TTBK2), ma(kin)) |
| pmid:21548880 | p(HGNC:CDK5R1) increases act(p(HGNC:CDK5)) |
| pmid:26118667 | p(HGNC:CDK5R1) partOf complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) |
| pmid:26118667 | p(HGNC:CDK5R1) negativeCorrelation p(HBP:"CDK5R1 p25") |
| pmid:21548880 | act(p(ECCODE:"3.4.22.52")) positiveCorrelation p(HGNC:TTBK1) |
| pmid:21548880 | p(HGNC:GRIN2B) negativeCorrelation p(HGNC:TTBK1) |
| pmid:21548880 | p(HGNC:GRIN2D) negativeCorrelation p(HGNC:TTBK1) |
| pmid:25673844 | p(HGNC:VRK1) isA p(HBP:"CK1 superfamily") |
| pmid:25673844 | p(HGNC:VRK2) isA p(HBP:"CK1 superfamily") |
| pmid:25673844 | p(HGNC:VRK3) isA p(HBP:"CK1 superfamily") |
| pmid:25673844 | p(HGNC:CSNK1A1L) isA p(FPLX:CSNK1) |
| pmid:25673844 | p(HGNC:CSNK1E) isA p(FPLX:CSNK1) |
| pmid:25673844 | p(HGNC:CSNK1G1) isA p(FPLX:CSNK1) |
| pmid:25673844 | p(HGNC:CSNK1G2) isA p(FPLX:CSNK1) |
| pmid:25673844 | p(HGNC:CSNK1G3) isA p(FPLX:CSNK1) |
| pmid:25673844 | p(HGNC:SV2A, pmod(Ph, Thr, 84)) association p(HGNC:SYT1) |
| pmid:25673844 | p(HGNC:SYT1) association p(HGNC:SV2A, pmod(Ph, Thr, 84)) |
| pmid:27607061 | surf(p(HGNC:GRIK2)) negativeCorrelation act(p(HGNC:RAB5A)) |
| pmid:26323690 | p(HGNC:KIF2A, pmod(Ph)) negativeCorrelation bp(GO:"microtubule depolymerization") |
| pmid:26323690 | bp(GO:"microtubule depolymerization") negativeCorrelation p(HGNC:KIF2A, pmod(Ph)) |
| pmid:26323690 | act(p(HGNC:SLC5A1)) positiveCorrelation bp(GO:"glucose transmembrane transport") |
| pmid:26323690 | bp(GO:"glucose transmembrane transport") positiveCorrelation act(p(HGNC:SLC5A1)) |
| pmid:26323690 | p(HGNC:CEP164) association p(HGNC:TTBK2) |
| pmid:26323690 | p(HGNC:CEP164) positiveCorrelation act(p(HGNC:TTBK2)) |
| pmid:26323690 | p(HGNC:CEP164) partOf complex(p(HGNC:CEP164), p(HGNC:DVL3)) |
| pmid:26323690 | p(HGNC:MAPRE1) association p(HGNC:TTBK2) |
| pmid:26323690 | p(HGNC:CEP164, pmod(Ph)) negativeCorrelation complex(p(HGNC:CEP164), p(HGNC:DVL3)) |
| pmid:26323690 | complex(p(HGNC:CEP164), p(HGNC:DVL3)) negativeCorrelation p(HGNC:CEP164, pmod(Ph)) |
| pmid:26323690 | p(HGNC:DVL3) partOf complex(p(HGNC:CEP164), p(HGNC:DVL3)) |
| pmid:24808823 | p(MGI:Ttbk1) negativeCorrelation bp(GO:learning) |
| pmid:24808823 | p(MGI:Ttbk1) increases a(HBP:pretangles) |
| pmid:24808823 | p(MGI:Ttbk1) increases bp(GO:"neuron death") |
| pmid:24808823 | surf(p(MGI:Grin2b)) positiveCorrelation bp(GO:learning) |
| pmid:11943212 | p(HGNC:MAPK11) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:11943212 | p(HGNC:MAPK11) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:11943212 | p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:11943212 | p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:11943212 | p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:11943212 | p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Thr, 396)) |
| pmid:11943212 | p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:11943212 | p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:11943212 | p(HGNC:MAPT, pmod(Ph, Thr, 396)) partOf p(HBP:"Tau epitope, AD2") |
| pmid:26751493 | p(HBP:"APOE e3") association p(HBP:"tubulin-binding repeat 1") |
| pmid:26751493 | p(INTERPRO:"Syntaxin, N-terminal domain") negativeCorrelation a(GO:"neurofibrillary tangle") |
| pmid:11943212 | p(HGNC:MARK4, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:11943212 | p(HGNC:MARK4, pmod(Ph)) positiveCorrelation a(HBP:"granulovacuolar degeneration") |
| pmid:22692785 | p(HGNC:MARK4) negativeCorrelation p(HBP:PrPSc) |
| pmid:23666762 | p(HGNC:MARK4) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:22156579 | p(HGNC:MARK4) increases a(HBP:"Tau epitope, 12E8") |
| pmid:22156579 | p(HGNC:MARK4) negativeCorrelation act(p(RGD:Dlg4)) |
| pmid:22156579 | p(HGNC:MARK4) negativeCorrelation p(RGD:Gria1) |
| pmid:22156579 | p(HGNC:MARK4) negativeCorrelation a(GO:"dendritic spine") |
| pmid:22156579 | p(HGNC:MARK4) negativeCorrelation a(GO:synapse) |
| pmid:22692785 | p(HBP:PrPSc) negativeCorrelation p(HGNC:MARK4) |
| pmid:22692785 | p(HBP:"PrP106-126") decreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:22156579 | p(INTERPRO:"Kinase associated domain 1 (KA1)") positiveCorrelation act(a(HBP:"amyloid-beta oligomers")) |
| pmid:22156579 | act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:22156579 | act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356)) |
| pmid:16973293 | p(HBP:"MARK4 isoform 2 (688 aa)") positiveCorrelation bp(GO:"neuron development") |
| pmid:16973293 | p(HBP:"MARK4 isoform 2 (688 aa)") isA p(HGNC:MARK4) |
| pmid:16973293 | bp(GO:"neuron development") positiveCorrelation p(HBP:"MARK4 isoform 2 (688 aa)") |
| pmid:23666762 | p(HBP:"Tau antibody, AGG5759") increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:23666762 | p(HBP:"Tau antibody, Tau-13") increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:23666762 | p(HBP:"CagA peptide") decreases act(p(HGNC:MARK4), ma(kin)) |
| pmid:27094130 | p(HGNC:DAPK1) increases sec(p(HGNC:APP, frag("672_713"))) |
| pmid:27094130 | act(p(HGNC:DAPK1), ma(kin)) positiveCorrelation sec(p(HGNC:APP, frag("672_713"))) |
| pmid:27094130 | p(HGNC:DAPK1) increases sec(p(HGNC:APP, frag("672_711"))) |
| pmid:27094130 | act(p(HGNC:DAPK1), ma(kin)) positiveCorrelation sec(p(HGNC:APP, frag("672_711"))) |
| pmid:27094130 | act(p(HGNC:DAPK1), ma(kin)) increases p(HGNC:APP, pmod(Ph, Thr, 668)) |
| pmid:27068745 | act(p(HGNC:DAPK1)) increases bp(GO:"neuron apoptotic process") |
| pmid:25899010 | p(HGNC:DAPK1) positiveCorrelation a(HBP:Excitotoxicity) |
| pmid:25899010 | p(HGNC:DAPK1) negativeCorrelation p(HGNC:PIN1) |
| pmid:27795443 | act(p(HGNC:DAPK1)) negativeCorrelation act(p(HGNC:JUND)) |
| pmid:27795443 | act(p(HGNC:DAPK1)) increases bp(GO:"apoptotic process") |
| pmid:24853415 | p(HGNC:DAPK1) increases p(HGNC:PIN1, pmod(Ph, Ser, 71)) |
| pmid:24853415 | p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:23948915 | p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:24853415 | p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:23948915 | p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:24853415 | p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:23948915 | p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:24853415 | p(HGNC:DAPK1) positiveCorrelation p(HGNC:MAPT) |
| pmid:21311567 | p(HGNC:DAPK1) directlyIncreases act(p(HGNC:MARK1)) |
| pmid:21311567 | p(HGNC:DAPK1) directlyIncreases act(p(HGNC:MARK2)) |
| pmid:21311567 | p(HGNC:DAPK1) decreases bp(GO:"microtubule polymerization") |
| pmid:27094130 | p(HGNC:DAPK1, frag("637_1423")) association p(HGNC:APP) |
| pmid:27094130 | p(HGNC:DAPK1, frag("637_1423")) partOf p(HGNC:DAPK1) |
| pmid:27094130 | p(HGNC:DAPK1, frag("848_1423")) association p(HGNC:APP) |
| pmid:27094130 | p(HGNC:DAPK1, frag("848_1423")) partOf p(HGNC:DAPK1) |
| pmid:27094130 | p(HGNC:DAPK1, frag("1271_1423")) association p(HGNC:APP) |
| pmid:27094130 | p(HGNC:DAPK1, frag("1271_1423")) equivalentTo p(INTERPRO:"Death domain") |
| pmid:27094130 | p(INTERPRO:"Death domain") equivalentTo p(HGNC:DAPK1, frag("1271_1423")) |
| pmid:27094130 | p(INTERPRO:"Death domain") partOf p(HGNC:DAPK1) |
| pmid:27068745 | p(HGNC:UNC5B) increases act(p(HGNC:DAPK1)) |
| pmid:27068745 | p(HGNC:UNC5B) positiveCorrelation act(p(FPLX:PPP2), ma(kin)) |
| pmid:27068745 | p(HGNC:UNC5C) positiveCorrelation bp(GO:"neuron apoptotic process") |
| pmid:27068745 | p(HGNC:UNC5C, var("p.Thr835Met")) increases bp(GO:"neuron apoptotic process") |
| pmid:27068745 | p(HGNC:UNC5C, var("p.Thr835Met")) positiveCorrelation act(p(HGNC:PRKD1)) |
| pmid:27068745 | p(HGNC:CALML5) decreases p(HGNC:UNC5C, var("p.Thr835Met")) |
| pmid:27068745 | act(p(HGNC:PRKD1)) positiveCorrelation p(HGNC:UNC5C, var("p.Thr835Met")) |
| pmid:27068745 | act(p(HGNC:PRKD1)) positiveCorrelation act(p(HGNC:MAP3K5)) |
| pmid:27068745 | act(p(HGNC:MAP3K5)) positiveCorrelation act(p(HGNC:PRKD1)) |
| pmid:27068745 | act(p(HGNC:MAP3K5)) increases act(p(FPLX:JNK)) |
| pmid:27068745 | act(p(HGNC:MAP3K5)) association p(HGNC:CASP3) |
| pmid:27068745 | p(ECCODE:"1.6.3.1") positiveCorrelation act(p(FPLX:JNK)) |
| pmid:27795443 | act(p(HGNC:JUND)) decreases bp(GO:"apoptotic process") |
| pmid:27795443 | act(p(HGNC:JUND)) negativeCorrelation act(p(HGNC:DAPK1)) |
| pmid:27133022 | p(HBP:"DAPK, basic loop (BL) motif") partOf p(HGNC:DAPK2) |
| pmid:27133022 | p(HBP:"DAPK, basic loop (BL) motif") positiveCorrelation act(p(HGNC:DAPK2)) |
| pmid:27133022 | p(HBP:"DAPK, basic loop (BL) motif") positiveCorrelation act(p(FPLX:CALM)) |
| pmid:27133022 | act(p(HGNC:DAPK2)) positiveCorrelation p(HBP:"DAPK, basic loop (BL) motif") |
| pmid:25995053 | p(MGI:Dapk1) association p(MGI:Mapt) |
| pmid:25995053 | p(MGI:Dapk1) directlyIncreases complex(p(MGI:Dapk1), p(MGI:Mapt)) |
| pmid:25995053 | p(MGI:Dapk1) increases p(MGI:Mapt, pmod(Ph, Ser, 262)) |
| pmid:25995053 | complex(p(MGI:Dapk1), p(MGI:Mapt)) increases bp(GO:"neuron apoptotic process") |
| pmid:25995053 | p(MGI:Mapt, pmod(Ph, Ser, 262)) decreases a(GO:"dendritic spine") |
| pmid:25125464 | p(MGI:Mapt, pmod(Ph, Ser, 262)) positiveCorrelation p(MGI:Crh) |
| pmid:24853415 | p(HGNC:PIN1, pmod(Ph, Ser, 71)) decreases act(p(HGNC:PIN1)) |
| pmid:24853415 | p(HGNC:PIN1, pmod(Ph, Ser, 71)) positiveCorrelation p(HGNC:MAPT) |
| pmid:22926167 | p(HGNC:PIN1, pmod(Ph, Ser, 71)) negativeCorrelation p(HGNC:MAPT) |
| pmid:21311567 | act(p(HGNC:MARK1)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:22952452 | act(p(HGNC:MARK1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:21311567 | act(p(HGNC:MARK1)) decreases bp(GO:"microtubule polymerization") |
| pmid:22952452 | p(HGNC:MARK1) negativeCorrelation p(HGNC:TRAK1) |
| pmid:22952452 | p(HGNC:MARK1) negativeCorrelation p(HGNC:RHOT1) |
| pmid:28137862 | p(MGI:Dcaf1) association p(MGI:Dyrk1a) |
| pmid:28137862 | p(MGI:Dcaf1) partOf complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) |
| pmid:28137862 | p(MGI:Dcaf1) association p(MGI:Hap1) |
| pmid:28137862 | p(MGI:Dyrk1a) association p(MGI:Dcaf1) |
| pmid:28137862 | p(MGI:Dyrk1a) partOf complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) |
| pmid:28137862 | p(MGI:Dyrk1a) negativeCorrelation p(MGI:Hap1) |
| pmid:29221819 | p(MGI:Dyrk1a) positiveCorrelation a(HBP:"granular layer of cerebellar cortex") |
| pmid:29221819 | p(MGI:Dyrk1a) positiveCorrelation a(HBP:"molecular layer of cerebellar cortex") |
| pmid:29221819 | p(MGI:Dyrk1a) positiveCorrelation a(HBP:"Purkinje cell layer of cerebellar cortex") |
| pmid:29221819 | p(MGI:Dyrk1a) positiveCorrelation bp(GO:"dendrite arborization") |
| pmid:29221819 | p(MGI:Dyrk1a) positiveCorrelation bp(GO:"cellular senescence") |
| pmid:29221819 | p(MGI:Dyrk1a) positiveCorrelation act(a(HBP:"cholinergic neuron")) |
| pmid:29221819 | p(MGI:Dyrk1a) negativeCorrelation p(MGI:App) |
| pmid:29221819 | p(MGI:Dyrk1a) negativeCorrelation a(CHEBI:"amyloid-beta") |
| pmid:29221819 | p(MGI:Dyrk1a) negativeCorrelation p(MGI:Mapt, pmod(Ph, Ser, 202)) |
| pmid:29221819 | p(MGI:Dyrk1a) negativeCorrelation p(MGI:Mapt) |
| pmid:28540658 | p(MGI:Dyrk1a) decreases a(CHEBI:serotonin) |
| pmid:28540658 | p(MGI:Dyrk1a) decreases a(CHEBI:dopamine) |
| pmid:28540658 | p(MGI:Dyrk1a) decreases a(CHEBI:adrenaline) |
| pmid:28775333 | p(MGI:Dyrk1a) positiveCorrelation p(HBP:"3R tau") |
| pmid:28775333 | p(MGI:Dyrk1a) negativeCorrelation p(HBP:"4R tau") |
| pmid:28775333 | p(MGI:Dyrk1a) positiveCorrelation path(MESH:Anxiety) |
| pmid:28775333 | p(MGI:Dyrk1a) negativeCorrelation bp(GO:memory) |
| pmid:28137862 | complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) negativeCorrelation p(MGI:Hap1) |
| pmid:28137862 | p(MGI:Hap1) association p(MGI:Dcaf1) |
| pmid:28137862 | p(MGI:Hap1) negativeCorrelation p(MGI:Dyrk1a) |
| pmid:28137862 | p(MGI:Hap1) negativeCorrelation complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) |
| pmid:29221819 | a(HBP:"granular layer of cerebellar cortex") positiveCorrelation p(MGI:Dyrk1a) |
| pmid:29221819 | a(HBP:"molecular layer of cerebellar cortex") positiveCorrelation p(MGI:Dyrk1a) |
| pmid:29221819 | a(HBP:"Purkinje cell layer of cerebellar cortex") positiveCorrelation p(MGI:Dyrk1a) |
| pmid:29221819 | bp(GO:"dendrite arborization") positiveCorrelation p(MGI:Dyrk1a) |
| pmid:29221819 | act(a(HBP:"cholinergic neuron")) positiveCorrelation p(MGI:Dyrk1a) |
| pmid:28884684 | a(HBP:"ID-8") decreases act(p(HGNC:DYRK1B), ma(kin)) |
| pmid:28884684 | a(HBP:"ID-8") decreases act(p(HGNC:GSK3B), ma(kin)) |
| pmid:28884684 | a(HBP:"ID-8") decreases act(p(HGNC:DYRK1A), ma(kin)) |
| pmid:28884684 | a(HBP:"ID-8") decreases bp(GO:"neuron differentiation") |
| pmid:28884684 | act(p(HGNC:DYRK1A), ma(kin)) positiveCorrelation bp(GO:"neuron differentiation") |
| pmid:28250274 | p(HGNC:DYRK1A) negativeCorrelation p(HGNC:MME) |
| pmid:28632203 | p(HGNC:DYRK1A) biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:28167836 | act(p(HGNC:DYRK1A)) regulates a(HBP:Neurites) |
| pmid:28167836 | act(p(HGNC:DYRK1A)) regulates a(GO:axon) |
| pmid:28250274 | a(CHEBI:harmine) decreases p(HGNC:DYRK1A) |
| pmid:28250274 | a(CHEBI:harmine) increases p(HGNC:MME) |
| pmid:29077046 | a(CHEBI:harmine) increases complex(a(CHEBI:harmine), g(HGNC:DYRK1A)) |
| pmid:28775333 | p(MGI:Mef2d) increases r(MGI:Dyrk1a) |
| pmid:28775333 | p(MGI:Mef2d) increases act(p(MGI:Dyrk1a), ma(kin)) |
| pmid:28632203 | composite(a(CHEBI:homocysteine), p(HGNC:BDNF), p(HGNC:DYRK1A)) biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:28167836 | p(HBP:"NP_001387.2:p.Arg205del") decreases act(p(HGNC:DYRK1A)) |
| pmid:28167836 | p(HBP:"NP_001387.2:p.Arg205del") positiveCorrelation path(MESH:"Autism Spectrum Disorder") |
| pmid:28167836 | p(HBP:"NP_001387.2:p.Glu239del") decreases act(p(HGNC:DYRK1A)) |
| pmid:28167836 | p(HBP:"NP_001387.2:p.Glu239del") positiveCorrelation path(MESH:"Autism Spectrum Disorder") |
| pmid:28167836 | path(MESH:"Autism Spectrum Disorder") positiveCorrelation p(HBP:"NP_001387.2:p.Arg205del") |
| pmid:28167836 | path(MESH:"Autism Spectrum Disorder") positiveCorrelation p(HBP:"NP_001387.2:p.Glu239del") |
| pmid:28877763 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 301)) |
| pmid:28877763 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Tyr, 18)) |
| pmid:25331948 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Tyr, 18)) |
| pmid:28877763 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 396)) |
| pmid:25331948 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 396)) |
| pmid:28877763 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 404)) |
| pmid:25331948 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 404)) |
| pmid:28877763 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt) |
| pmid:25331948 | p(MGI:Syk) positiveCorrelation a(CHEBI:"amyloid-beta") |
| pmid:25331948 | p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 202)) |
| pmid:28877763 | p(MGI:Mapt, pmod(Ph, Ser, 301)) positiveCorrelation p(MGI:Syk) |
| pmid:28877763 | p(MGI:Syk, pmod(Ph)) positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pmid:28877763 | p(MGI:Syk, pmod(Ph)) partOf a(HBP:"dystrophic neurite") |
| pmid:28877763 | p(MGI:Mapt, pmod(Ph, Tyr, 18)) positiveCorrelation p(MGI:Syk) |
| pmid:25331948 | p(MGI:Mapt, pmod(Ph, Tyr, 18)) positiveCorrelation p(MGI:Syk) |
| pmid:28877763 | p(HGNC:SYK, pmod(Ph)) positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pmid:28877763 | p(HGNC:SYK, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18)) |
| pmid:26501932 | p(HGNC:SYK) partOf a(HBP:pretangles) |
| pmid:26501932 | p(HGNC:SYK) partOf a(HBP:"GVD bodies") |
| pmid:25331948 | act(p(HGNC:SYK)) negativeCorrelation p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:25331948 | act(p(HGNC:SYK)) positiveCorrelation act(p(HGNC:GSK3B), ma(kin)) |
| pmid:23702978 | act(p(HGNC:SYK)) increases complex(p(HGNC:CASP8), p(HGNC:MALT1)) |
| pmid:18070606 | p(RGD:Syk) increases p(RGD:Mapt, pmod(Ph, Tyr, 18)) |
| pmid:26501932 | a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") partOf a(GO:"synaptic vesicle") |
| pmid:26501932 | a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") association a(HBP:"GVD bodies") |
| pmid:26501932 | a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") partOf a(HBP:pretangles) |
| pmid:26501932 | a(HBP:"GVD bodies") association a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta") |
| pmid:25331948 | a(CHEBI:Nilvadipine) directlyDecreases complex(GO:"L-type voltage-gated calcium channel complex") |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:25331948 | a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:25331948 | a(HBP:"Tau epitope, CP13") equivalentTo p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:25331948 | a(HBP:"BAY61-3606") directlyDecreases act(p(HGNC:SYK)) |
| pmid:28176663 | a(HBP:"Braak_Stage V") negativeCorrelation act(p(HGNC:GSK3B), ma(kin)) |
| pmid:28176663 | a(HBP:"advanced glycation end product") increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| pmid:28176663 | a(HBP:"advanced glycation end product") increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) |
| pmid:28176663 | a(HBP:"advanced glycation end product") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:25987199 | act(a(HBP:"advanced glycation end product")) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:25987199 | act(a(HBP:"advanced glycation end product")) negativeCorrelation act(p(MGI:Glp1r)) |
| pmid:26118667 | complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) increases act(p(HGNC:CDK5)) |
| pmid:26118667 | p(HBP:"CDK5R1 p25") negativeCorrelation p(HGNC:CDK5R1) |
| pmid:26118667 | p(HBP:"CDK5R1 p25") equivalentTo p(HGNC:CDK5R1, frag("99_307")) |
| pmid:26118667 | p(HBP:"CDK5R1 p25") positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:26118667 | p(HBP:"CDK5R1 p25") positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:27087442 | p(HBP:"CDK5R1 p25") positiveCorrelation p(HBP:"Tau epitope, AT8") |
| pmid:14642273 | p(HBP:"CDK5R1 p25") directlyIncreases act(p(MGI:Cdk5), ma(kin)) |
| pmid:14642273 | p(HBP:"CDK5R1 p25") increases p(HBP:"Tau aggregates") |
| pmid:26118667 | p(HGNC:CDK5R1, frag("99_307")) equivalentTo p(HBP:"CDK5R1 p25") |
| pmid:26118667 | a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Ser, 202)) |
| pmid:26118667 | a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Thr, 205)) |
| pmid:26118667 | a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Ser, 262)) |
| pmid:26118667 | a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Thr, 231)) |
| pmid:26118667 | a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Ser, 422)) |
| pmid:26118667 | a(HBP:"Chronic cerebral hypoperfusion") increases p(HBP:"CDK5R1 p25") |
| pmid:26118667 | a(HBP:"Chronic cerebral hypoperfusion") increases p(FPLX:NFkappaB) |
| pmid:26118667 | m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:26118667 | m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:26118667 | m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:26118667 | m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:26118667 | m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:26118667 | m(MIRBASE:"rno-mir-195") increases complex(g(RGD:Cdk5r1), m(MIRBASE:"rno-mir-195")) |
| pmid:26118667 | m(MIRBASE:"rno-mir-195") negativeCorrelation p(RGD:App) |
| pmid:26118667 | m(MIRBASE:"rno-mir-195") negativeCorrelation p(RGD:Bace1) |
| pmid:26118667 | m(MIRBASE:"rno-mir-195") negativeCorrelation a(CHEBI:"amyloid-beta") |
| pmid:26118667 | m(MIRBASE:"rno-mir-195") negativeCorrelation p(RGD:Cdk5r1) |
| pmid:26118667 | complex(g(RGD:Cdk5r1), m(MIRBASE:"rno-mir-195")) decreases r(RGD:Cdk5r1) |
| pmid:26118667 | complex(g(MIRBASE:"rno-mir-195"), p(FPLX:NFkappaB)) decreases m(MIRBASE:"rno-mir-195") |
| pmid:26118667 | p(RGD:App) negativeCorrelation m(MIRBASE:"rno-mir-195") |
| pmid:26118667 | p(RGD:Bace1) negativeCorrelation m(MIRBASE:"rno-mir-195") |
| pmid:26118667 | p(INTERPRO:"Peptidase C2, calpain, catalytic domain") positiveCorrelation act(p(RGD:Cdk5r1)) |
| pmid:26118667 | act(p(RGD:Cdk5r1)) positiveCorrelation p(INTERPRO:"Peptidase C2, calpain, catalytic domain") |
| pmid:26118667 | p(RGD:Cdk5r1) negativeCorrelation m(MIRBASE:"rno-mir-195") |
| pmid:27087442 | path(MESH:Cognition) negativeCorrelation p(MGI:Cdk5) |
| pmid:25987199 | act(p(MGI:Glp1r)) increases act(p(MGI:Ppargc1a)) |
| pmid:25987199 | act(p(MGI:Glp1r)) decreases act(p(MGI:Gsk3b), ma(kin)) |
| pmid:25987199 | act(p(MGI:Glp1r)) decreases p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) |
| pmid:25987199 | act(p(MGI:Glp1r)) negativeCorrelation act(a(HBP:"advanced glycation end product")) |
| pmid:25143394 | p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(MGI:Ppp1ca) |
| pmid:25143394 | p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(MGI:Ppp2ca) |
| pmid:25143394 | p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(MGI:Ppp1cb) |
| pmid:23134599 | p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(RGD:Ppp2ca) |
| pmid:25125464 | p(MGI:Crhr1) positiveCorrelation p(HBP:"Tau epitope, AT8") |
| pmid:25125464 | p(MGI:Crhr1) positiveCorrelation a(HBP:"Tau epitope, PHF1") |
| pmid:25125464 | p(MGI:Crhr1) positiveCorrelation p(MGI:Mapk8) |
| pmid:25125464 | p(MGI:Crhr1) positiveCorrelation a(HBP:"Tau aggregates") |
| pmid:25125464 | p(MGI:Mapt, pmod(Ph, Ser, 422)) positiveCorrelation p(MGI:Crh) |
| pmid:25125464 | p(MGI:Mapk8) positiveCorrelation p(MGI:Crhr1) |
| pmid:25125464 | a(GO:"neuron spine") positiveCorrelation p(MGI:Fyn) |
| pmid:19459590 | p(HBP:"Tau epitope, CP13") equivalentTo p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:19459590 | p(HBP:"Tau epitope, CP13") decreases act(p(HGNC:MAPT)) |
| pmid:23294633 | a(HBP:"Tau epitope, AT100") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pmid:22833681 | p(HGNC:MAPT, pmod(Ph, Thr, 214)) partOf a(HBP:"Tau epitope, AT100") |
| pmid:22833681 | p(HGNC:MAPT, pmod(Ph, Ser, 212)) partOf a(HBP:"Tau epitope, AT100") |
| pmid:22833681 | a(HBP:"Thiamet G") directlyDecreases act(p(ECCODE:"3.2.1.169")) |
| pmid:22833681 | act(p(ECCODE:"3.2.1.169")) increases p(MGI:Mapt, pmod(HBP:"O-GlcNAcylation")) |
| pmid:23294633 | p(MGI:Gsk3b, pmod(Ph, Tyr, 279)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pmid:23294633 | p(MGI:Gsk3b, pmod(Ph, Tyr, 279)) increases act(p(MGI:Gsk3b), ma(kin)) |
| pmid:23294633 | p(MGI:Gsk3b, pmod(Ph, Tyr, 216)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pmid:23294633 | p(MGI:Gsk3b, pmod(Ph, Tyr, 216)) increases act(p(MGI:Gsk3b), ma(kin)) |
| pmid:22002427 | p(HGNC:MAPT, pmod(Ph, Ser, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Glu391*")) |
| pmid:22002427 | p(HGNC:MAPT, pmod(Ph, Ser, 205)) positiveCorrelation a(GO:"neurofibrillary tangle") |
| pmid:24033439 | p(HBP:"Tau epitope, PHF1") biomarkerFor path(MESH:"Alzheimer Disease") |
| pmid:24033439 | p(HBP:"Tau epitope, PHF1") increases a(GO:"neurofibrillary tangle") |
| pmid:24251416 | p(HGNC:MAPT, pmod(Ph, Ser, 352)) partOf p(HBP:"tubulin-binding repeat 4") |
| pmid:22156579 | act(p(RGD:Dlg4)) negativeCorrelation p(HGNC:MARK4) |
| pmid:22156579 | p(RGD:Gria1) negativeCorrelation p(HGNC:MARK4) |
| pmid:22941973 | act(p(INTERPRO:"14-3-3 domain")) increases p(RGD:Mapt, pmod(Ph, Ser, 262)) |
| pmid:22941973 | act(p(INTERPRO:"14-3-3 domain")) decreases bp(GO:"microtubule polymerization") |
| pmid:22941973 | act(p(INTERPRO:"14-3-3 domain")) increases deg(p(RGD:Syp)) |
| pmid:22941973 | act(p(INTERPRO:"14-3-3 domain")) negativeCorrelation a(CHEBI:paclitaxel) |
| pmid:23722080 | a(CHEBI:"sodium azide") directlyDecreases a(GO:mitochondrion) |
| pmid:23722080 | a(CHEBI:"sodium azide") positiveCorrelation composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) |
| pmid:23722080 | composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) positiveCorrelation a(CHEBI:"hydrogen peroxide") |
| pmid:23722080 | composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) positiveCorrelation a(CHEBI:"sodium azide") |
| pmid:23722080 | composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases a(CHEBI:"glutamate(1-)") |
| pmid:23722080 | composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(RGD:Mapt, pmod(Ph, Ser, 262)) |
| pmid:23722080 | composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(RGD:Mapt, pmod(Ph, Ser, 404)) |
| pmid:23722080 | composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(RGD:Bace1) |
| pmid:23722080 | composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(HBP:"CDK5R1 p25") |
| pmid:23722080 | composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) decreases bp(GO:"cellular metabolic process") |
| pmid:23722080 | composite(a(CHEBI:"L-ascorbic acid"), a(CHEBI:Trolox), a(CHEBI:glutathione)) decreases p(RGD:Mapt, pmod(Ph, Ser, 262)) |
| pmid:23722080 | composite(a(CHEBI:"L-ascorbic acid"), a(CHEBI:Trolox), a(CHEBI:glutathione)) decreases p(RGD:Mapt, pmod(Ph, Ser, 404)) |
| pmid:23722080 | composite(a(CHEBI:"L-ascorbic acid"), a(CHEBI:Trolox), a(CHEBI:glutathione)) increases bp(GO:"cellular metabolic process") |
| pmid:22952452 | p(HGNC:TRAK1) positiveCorrelation act(a(GO:mitochondrion)) |
| pmid:22952452 | p(HGNC:TRAK1) decreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:22952452 | p(HGNC:TRAK1) negativeCorrelation p(HGNC:MARK1) |
| pmid:22952452 | p(HGNC:RHOT1) positiveCorrelation act(a(GO:mitochondrion)) |
| pmid:22952452 | p(HGNC:RHOT1) decreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:22952452 | p(HGNC:RHOT1) negativeCorrelation p(HGNC:MARK1) |
| pmid:23001711 | p(HGNC:CHEK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:22072628 | p(HBP:"proline-rich region 2", pmod(Ph)) positiveCorrelation bp(MESH:"Protein Conformation, alpha-Helical") |
| pmid:22072628 | p(HGNC:MAPT, frag("235_324")) association bp(MESH:"Protein Conformation, alpha-Helical") |
| pmid:8226987 | p(HGNC:MAPT, pmod(Ph, Ser, 261)) decreases act(p(HGNC:MAPT)) |
| pmid:24401760 | p(HGNC:ITPKB) positiveCorrelation path(MESH:"Plaque, Amyloid") |
| pmid:24401760 | p(HGNC:ITPKB) partOf a(HBP:"dystrophic neurite") |
| pmid:24401760 | p(MGI:Itpkb) increases bp(GO:"apoptotic process") |
| pmid:24401760 | p(MGI:Itpkb) increases p(MGI:Bace1) |
| pmid:24401760 | p(MGI:Itpkb) increases act(p(MGI:Bace1)) |
| pmid:24401760 | p(MGI:Itpkb) increases act(p(MGI:Map2k1)) |
| pmid:24401760 | p(MGI:Itpkb) increases act(p(MGI:Map2k2)) |
| pmid:24401760 | p(MGI:Itpkb) increases a(HBP:Astrogliosis) |
| pmid:24401760 | p(MGI:Itpkb) increases p(HGNC:APP, frag("672_711")) |
| pmid:24401760 | p(MGI:Itpkb) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:24401760 | a(HBP:"SL-327") directlyDecreases p(MGI:Map2k1) |
| pmid:24401760 | a(HBP:"SL-327") directlyDecreases p(MGI:Map2k2) |
| pmid:24401760 | a(HBP:"SL-327") decreases a(CHEBI:"amyloid-beta") |
| pmid:23737518 | a(HBP:"LDN-193594") directlyDecreases act(p(RGD:Cdk5)) |
| pmid:23737518 | a(HBP:"LDN-193594") decreases a(HBP:"Tau epitope, PHF1") |
| pmid:23737518 | a(HBP:"LDN-193594") decreases act(p(HBP:"CDK5R1 p25")) |
| pmid:23737518 | a(HBP:"LDN-193594") directlyDecreases act(p(RGD:Gsk3b)) |
| pmid:23737518 | a(HBP:"LDN-193594") isA a(HBP:diaminothiazole) |
| pmid:23737518 | a(HBP:"LDN-193665") isA a(HBP:diaminothiazole) |
| pmid:23737518 | a(HBP:"LDN-193665") directlyDecreases act(p(RGD:Cdk5)) |
| pmid:23737518 | a(HBP:"LDN-193665") directlyDecreases act(p(RGD:Gsk3b)) |
| pmid:23737518 | a(HBP:"LDN-213843") isA a(HBP:diaminothiazole) |
| pmid:23737518 | a(HBP:"LDN-213843") directlyDecreases act(p(RGD:Cdk5)) |
| pmid:23737518 | a(HBP:"LDN-213843") directlyDecreases act(p(RGD:Gsk3b)) |
| pmid:7667312 | p(HGNC:MAPT, var("p.Cys291Ala")) decreases a(HBP:"paired helical filaments") |
| pmid:7667312 | a(HBP:"Thioflavin S") positiveCorrelation a(HBP:"paired helical filaments") |
| pmid:25672970 | a(HBP:"C-30-27") directlyDecreases act(p(HGNC:KAT2B)) |
| pmid:25672970 | a(HBP:"C-30-27") increases path(MESH:Cognition) |
| pmid:25672970 | act(p(HGNC:KAT2B)) positiveCorrelation p(FPLX:NFkappaB, pmod(Ac, Lys, 122)) |
| pmid:25546293 | p(HGNC:KAT2B) increases p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) |
| pmid:24686445 | act(p(HGNC:KAT2B)) positiveCorrelation act(p(FPLX:ERK)) |
| pmid:24686445 | act(p(HGNC:KAT2B)) increases p(HBP:"Histone H3", pmod(Ac, Lys, 9)) |
| pmid:25672970 | p(FPLX:NFkappaB, pmod(Ac, Lys, 122)) positiveCorrelation act(p(HGNC:KAT2B)) |
| pmid:11691934 | p(HGNC:EP300) increases p(FPLX:"Histone_H4", pmod(Ac)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 163)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 174)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 180)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 254)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 274)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 280)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 281)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 290)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 298)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 317)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 321)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 331)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 352)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 369)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 370)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 383)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 385)) |
| pmid:20869593 | act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 395)) |
| pmid:24844691 | a(HBP:"Tubastatin A") directlyDecreases act(p(HGNC:HDAC6)) |
| pmid:24844691 | a(HBP:"Tubastatin A") decreases a(CHEBI:"amyloid-beta") |
| pmid:24844691 | a(HBP:"Tubastatin A") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| pmid:24844691 | a(HBP:"ACY-1215") directlyDecreases act(p(HGNC:HDAC6)) |
| pmid:24844691 | a(HBP:"ACY-1215") decreases a(CHEBI:"amyloid-beta") |
| pmid:25546293 | p(HGNC:CTNNB1, pmod(Ph, Ser, 33)) increases deg(p(HGNC:CTNNB1)) |
| pmid:25546293 | p(HGNC:CTNNB1, pmod(Ph, Ser, 37)) increases deg(p(HGNC:CTNNB1)) |
| pmid:25546293 | p(HGNC:CTNNB1, pmod(Ph, Thr, 41)) increases deg(p(HGNC:CTNNB1)) |
| pmid:25546293 | p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) decreases p(HGNC:CTNNB1, pmod(Ub)) |
| pmid:25546293 | p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) increases p(HGNC:CTNNB1, loc(GO:membrane)) |
| pmid:25546293 | p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) negativeCorrelation act(p(HGNC:HDAC6)) |
| pmid:25546293 | a(CHEBI:vorinostat) directlyDecreases act(p(HGNC:HDAC6)) |
| pmid:25546293 | a(CHEBI:vorinostat) increases p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) |
| pmid:25546293 | a(HBP:crebinostat) directlyDecreases act(p(HGNC:HDAC6)) |
| pmid:25546293 | a(HBP:crebinostat) increases p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) |
| pmid:27917100 | a(HBP:ST7612AA1) directlyDecreases act(p(FPLX:HDAC)) |
| pmid:21427723 | act(p(FPLX:HDAC)) decreases p(HGNC:MAPT, pmod(Ac)) |
| pmid:26890116 | a(HBP:"Biphenyl-4-yl-acrylohydroxamoc acids") directlyDecreases act(p(FPLX:HDAC)) |
| pmid:18558669 | a(HBP:Trithiocarbonates) directlyDecreases act(p(HGNC:HDAC6)) |
| pmid:29540553 | p(MGI:Sirt1) decreases p(MGI:Mapt, pmod(Ac, Lys, 174)) |
| pmid:29540553 | p(MGI:Sirt1) positiveCorrelation a(GO:"neuron to neuron synapse") |
| pmid:29540553 | p(MGI:Sirt1) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29540553 | a(GO:"neuron to neuron synapse") positiveCorrelation p(MGI:Sirt1) |
| pmid:29540553 | p(MGI:Sirt3) negativeCorrelation p(HGNC:APP, frag("672_713")) |
| pmid:29540553 | p(MGI:Sirt3) negativeCorrelation p(HGNC:MAPT) |
| pmid:29540553 | p(MGI:Sirt3) negativeCorrelation p(HGNC:MAPT, pmod(Ac)) |
| pmid:29540553 | p(MGI:Sirt3) negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29276758 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:21427723 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:29276758 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) decreases a(MESH:Neurons) |
| pmid:29276758 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Chronic Traumatic Encephalopathy") |
| pmid:28855586 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) association composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) |
| pmid:28287136 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:28287136 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) increases a(HBP:"Tau aggregates") |
| pmid:28287136 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) partOf p(HBP:"VQIINK motif") |
| pmid:26940749 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| pmid:26940749 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) increases a(HBP:Neurodegeneration) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) isA p(HGNC:MAPT, pmod(Ac)) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) partOf a(HBP:"microtubule-binding region") |
| pmid:21427723 | p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(HBP:"Corticobasal Degeneration") |
| pmid:27550730 | a(HBP:"CM-414") directlyDecreases act(p(MGI:Pde5a)) |
| pmid:27550730 | a(HBP:"CM-414") directlyDecreases act(p(ECCODE:"3.5.1.98")) |
| pmid:27550730 | a(HBP:"CM-414") decreases a(CHEBI:"amyloid-beta") |
| pmid:27550730 | a(HBP:"CM-414") decreases p(MGI:Mapt, pmod(Ph)) |
| pmid:27550730 | a(HBP:"CM-414") decreases act(p(MGI:Gsk3b), ma(kin)) |
| pmid:27550730 | act(p(HGNC:PDE5A)) negativeCorrelation act(p(FPLX:CREB)) |
| pmid:29559585 | p(MGI:Gapdh, pmod(NO)) increases act(p(MGI:Ep300)) |
| pmid:29559585 | p(MGI:Gapdh, pmod(NO)) positiveCorrelation p(MGI:Mapt, pmod(Ac, Lys, 280)) |
| pmid:29559585 | act(p(MGI:Ep300)) positiveCorrelation p(MGI:Sirt1, pmod(NO)) |
| pmid:29559585 | p(MGI:Sirt1, pmod(NO)) positiveCorrelation act(p(MGI:Ep300)) |
| pmid:29559585 | p(MGI:Sirt1, pmod(NO)) increases act(p(MGI:Sirt1)) |
| pmid:29559585 | p(MGI:Mapt, pmod(Ac, Lys, 280)) positiveCorrelation p(MGI:Gapdh, pmod(NO)) |
| pmid:29559585 | a(HBP:CGP3466B) decreases p(MGI:Gapdh, pmod(NO)) |
| pmid:28855586 | p(HGNC:MAPT, pmod(Ac, Lys, 163)) association composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 163)) isA p(HGNC:MAPT, pmod(Ac)) |
| pmid:28855586 | composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) association p(HGNC:MAPT, pmod(Ac, Lys, 163)) |
| pmid:28855586 | composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) association p(HGNC:MAPT, pmod(Ac, Lys, 280)) |
| pmid:28855586 | composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) association p(HGNC:MAPT, pmod(Ac, Lys, 281)) |
| pmid:28855586 | composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) association p(HGNC:MAPT, pmod(Ac, Lys, 369)) |
| pmid:28855586 | composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) decreases p(HGNC:MAPT, pmod(Ph)) |
| pmid:28855586 | composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) decreases act(p(HGNC:MAPT)) |
| pmid:28855586 | composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) negativeCorrelation act(a(CHEBI:"amyloid-beta")) |
| pmid:28855586 | p(HGNC:MAPT, pmod(Ac, Lys, 281)) association composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) |
| pmid:28287136 | p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:28287136 | p(HGNC:MAPT, pmod(Ac, Lys, 281)) increases a(HBP:"Tau aggregates") |
| pmid:28287136 | p(HGNC:MAPT, pmod(Ac, Lys, 281)) partOf p(HBP:"VQIINK motif") |
| pmid:27041503 | p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases p(HGNC:WWC1) |
| pmid:27041503 | p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases bp(GO:"actin filament polymerization") |
| pmid:28855586 | p(HGNC:MAPT, pmod(Ac, Lys, 369)) association composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 369)) isA p(HGNC:MAPT, pmod(Ac)) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 369)) partOf a(HBP:"microtubule-binding region") |
| pmid:28287136 | p(HGNC:MAPT, var("p.Lys280Gln")) increases a(HBP:"Tau aggregates") |
| pmid:28002468 | p(HGNC:MAP4, frag("992_999")) equivalentTo p(HBP:"VQIINK motif") |
| pmid:28002468 | p(HGNC:MAP4, frag("1023_1030")) equivalentTo p(HBP:"VQIINK motif") |
| pmid:28002468 | p(HGNC:MAP2, frag("332_339")) equivalentTo p(HBP:"VQIVYK motif") |
| pmid:28002468 | a(HBP:"cystein-dependent auto-acetylation") increases p(HGNC:MAPT, pmod(Ac)) |
| pmid:28002468 | a(HBP:"cystein-dependent auto-acetylation") increases p(HGNC:MAP2, pmod(Ac)) |
| pmid:27041503 | p(HGNC:WWC1) negativeCorrelation bp(MESH:"Long-Term Potentiation") |
| pmid:26390242 | p(HGNC:MAPT, pmod(Ac, Lys, 174)) decreases deg(p(HGNC:MAPT)) |
| pmid:26390242 | p(HGNC:MAPT, pmod(Ac, Lys, 174)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:26390242 | p(HGNC:MAPT, pmod(Ac, Lys, 174)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| pmid:26390242 | p(HGNC:MAPT, pmod(Ac, Lys, 174)) increases a(HBP:Neurodegeneration) |
| pmid:29540553 | p(HGNC:MAPT, pmod(Ac, Lys, 174)) negativeCorrelation act(p(HGNC:SIRT1)) |
| pmid:26390242 | a(CHEBI:salsalate) directlyDecreases act(p(HGNC:EP300)) |
| pmid:26390242 | a(CHEBI:salsalate) decreases p(HGNC:MAPT, pmod(Ac, Lys, 174)) |
| pmid:26390242 | a(CHEBI:salsalate) decreases p(HGNC:MAPT) |
| pmid:26390242 | a(CHEBI:salsalate) positiveCorrelation a(MESH:Hippocampus) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 225)) isA p(HGNC:MAPT, pmod(Ac)) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 259)) isA p(HGNC:MAPT, pmod(Ac)) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 259)) partOf a(HBP:"microtubule-binding region") |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 317)) isA p(HGNC:MAPT, pmod(Ac)) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 317)) partOf a(HBP:"microtubule-binding region") |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 321)) isA p(HGNC:MAPT, pmod(Ac)) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 321)) partOf a(HBP:"microtubule-binding region") |
| pmid:28760828 | p(HGNC:MAPT, pmod(Ac, Lys, 321)) decreases p(HBP:"Tau aggregates") |
| pmid:28760828 | p(HGNC:MAPT, pmod(Ac, Lys, 321)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 324)) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 331)) isA p(HGNC:MAPT, pmod(Ac)) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 331)) partOf a(HBP:"microtubule-binding region") |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 343)) isA p(HGNC:MAPT, pmod(Ac)) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 343)) partOf a(HBP:"microtubule-binding region") |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 347)) isA p(HGNC:MAPT, pmod(Ac)) |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 347)) partOf a(HBP:"microtubule-binding region") |
| pmid:26192747 | p(HGNC:MAPT, pmod(Ac, Lys, 385)) isA p(HGNC:MAPT, pmod(Ac)) |
| pmid:24686445 | a(HBP:"peripheral nervous system injury") increases p(HGNC:NGF) |
| pmid:24686445 | p(HBP:"Histone H3", pmod(Ac, Lys, 9)) increases r(HGNC:GAP43) |
| pmid:24686445 | p(HBP:"Histone H3", pmod(Ac, Lys, 9)) increases r(HGNC:GAL) |
| pmid:24686445 | p(HBP:"Histone H3", pmod(Ac, Lys, 9)) increases r(HGNC:BDNF) |
| pmid:23487739 | a(HBP:Tubacin) directlyDecreases act(p(HGNC:HDAC6)) |
| pmid:21427723 | a(CHEBI:"trichostatin A") directlyDecreases act(p(FPLX:HDAC)) |
| pmid:21427723 | a(CHEBI:"trichostatin A") increases p(HGNC:MAPT, pmod(Ac)) |
| pmid:20869593 | a(HBP:C646) directlyDecreases act(p(HGNC:EP300)) |
| pmid:20869593 | a(HBP:C646) decreases p(HGNC:MAPT, pmod(Ac)) |
| pmid:29540553 | a(HBP:"Pathological Tau Spreading") negativeCorrelation act(p(HGNC:SIRT1)) |
| pmid:29226865 | p(HGNC:SRSF2, pmod(Ac, Lys, 52)) positiveCorrelation act(p(HGNC:SRSF2)) |
| pmid:29226865 | act(p(HGNC:SRSF2)) positiveCorrelation p(HGNC:SRSF2, pmod(Ac, Lys, 52)) |
| pmid:29226865 | act(p(HGNC:SRSF2)) increases p(HBP:"4R tau") |
| pmid:28771976 | p(HGNC:HDAC3) increases act(a(CL:0000129)) |
| pmid:28771976 | p(HGNC:HDAC3) increases a(CHEBI:"amyloid-beta") |
| pmid:28771976 | p(HGNC:HDAC3) decreases a(GO:"dendritic spine") |
| pmid:28771976 | a(HBP:RGFP966) directlyDecreases act(p(HGNC:HDAC3)) |
| pmid:28771976 | a(HBP:RGFP966) association bp(GO:memory) |
| pmid:29844403 | a(HBP:MPT0G211) directlyDecreases act(p(HGNC:HDAC6)) |
| pmid:29844403 | a(HBP:MPT0G211) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) |
| pmid:29844403 | a(HBP:MPT0G211) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| pmid:29844403 | a(HBP:MPT0G211) decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| pmid:29844403 | a(HBP:MPT0G211) increases bp(GO:learning) |
| pmid:29844403 | a(HBP:MPT0G211) increases bp(GO:memory) |
| pmid:19732809 | a(HBP:"O-GlcNAcylation") negativeCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19732809 | a(HBP:"O-GlcNAcylation") negativeCorrelation path(MESH:"Diabetes Mellitus, Type 2") |
| pmid:19732809 | a(HBP:"O-GlcNAcylation") association bp(MESH:"Hot Temperature") |
| pmid:19732809 | a(HBP:"O-GlcNAcylation") negativeCorrelation act(complex(GO:"proteasome complex")) |
| pmid:19732809 | g(HGNC:OGT) positiveCorrelation act(complex(GO:"proteasome complex")) |
| pmid:26041011 | a(HBP:"USP14 Aptamer") decreases act(p(HGNC:USP14)) |
| pmid:27325702 | p(HBP:"APP, ACR") association p(HGNC:STUB1) |
| pmid:27325702 | p(HBP:"APP, ACR") association p(HBP:"CRL4 complex") |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:SCAMP1, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:SV2A, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:SV2B, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:VAMP2, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:ATP6V0A1, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:SLC17A7, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:SYT1, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:SYT2, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:RAB14, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:SNAP25, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:SYN2, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:SYN1, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:RAB3A, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:APOE, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") increases p(HGNC:MAPT, pmod(Ub)) |
| pmid:27325702 | p(HBP:"APP, ACR") regulates complex(GO:"ubiquitin ligase complex") |
| pmid:27325702 | p(HBP:"CRL4 complex") association p(HBP:"APP, ACR") |
| pmid:27325702 | p(HBP:"CRL4 complex") equivalentTo complex(p(HGNC:CRBN), p(HGNC:CUL4A), p(HGNC:CUL4B), p(HGNC:DDB1)) |
| pmid:27325702 | p(HBP:"CRL4 complex") isA complex(GO:"ubiquitin ligase complex") |
| pmid:27325702 | complex(p(HGNC:CRBN), p(HGNC:CUL4A), p(HGNC:CUL4B), p(HGNC:DDB1)) equivalentTo p(HBP:"CRL4 complex") |
| pmid:25378699 | p(HGNC:MAPT, pmod(Sumo, Lys, 340)) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:25378699 | p(HGNC:MAPT, pmod(Sumo, Lys, 340)) decreases p(HGNC:MAPT, pmod(Ub)) |
| pmid:16464864 | p(HGNC:MAPT, pmod(Sumo, Lys, 340)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:24905733 | p(HGNC:MARCH7) increases p(HGNC:MAPT, pmod(Ub)) |
| pmid:8391280 | p(HGNC:MAPT, pmod(Ub, Lys, 257)) positiveCorrelation a(HBP:"paired helical filaments") |
| pmid:8391280 | p(HGNC:MAPT, pmod(Ub, Lys, 311)) positiveCorrelation a(HBP:"paired helical filaments") |
| pmid:27260838 | p(HBP:"Tau antibody, TNT1") association p(HBP:"phosphatase-activating domain") |
| pmid:27260838 | p(HBP:"Tau antibody, TNT2") association p(HBP:"phosphatase-activating domain") |
| pmid:27260838 | p(HBP:pretangles) positiveCorrelation p(HBP:"phosphatase-activating domain") |
| pmid:27601475 | a(HBP:"8-nitro-cGMP") decreases a(HBP:"Tau oligomers") |
| pmid:27601475 | a(HBP:"8-nitro-cGMP") positiveCorrelation a(CHEBI:"nitric oxide") |
| pmid:27601475 | act(p(ECCODE:"1.14.13.39")) directlyIncreases a(CHEBI:"nitric oxide") |
| pmid:27373205 | p(HBP:"Tau dimers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) |
| pmid:11606569 | p(HGNC:MAPT, var("p.Lys280del")) equivalentTo g(DBSNP:rs63750688) |
| pmid:11606569 | p(HGNC:MAPT, var("p.Lys280del")) positiveCorrelation p(HBP:"VQIINK motif") |
| pmid:11606569 | p(HGNC:MAPT, var("p.Lys280del")) positiveCorrelation p(HBP:"VQIVYK motif") |
| pmid:11606569 | g(DBSNP:rs63750688) equivalentTo p(HGNC:MAPT, var("p.Lys280del")) |
| pmid:27716675 | a(HBP:neuroinflammation) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) |
| pmid:27716675 | a(HBP:neuroinflammation) positiveCorrelation g(DBSNP:rs63751438) |
| pmid:27716675 | a(HBP:neuroinflammation) positiveCorrelation a(HBP:"Tau oligomers") |
| pmid:27716675 | g(DBSNP:rs63751438) positiveCorrelation a(HBP:neuroinflammation) |
| pmid:19765634 | g(DBSNP:rs761059) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:19765634 | g(DBSNP:rs8052688) positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pmid:19765634 | g(DBSNP:rs8063) positiveCorrelation path(MESH:"Cognitive Dysfunction") |
| pmid:21843595 | p(MGI:Sumo3) negativeCorrelation bp(GO:learning) |
| pmid:21843595 | p(MGI:Sumo3) negativeCorrelation bp(GO:memory) |
| pmid:19782030 | act(p(RGD:Stat1)) increases r(RGD:Irf1) |
| pmid:19782030 | act(p(RGD:Stat1)) increases r(RGD:Tnf) |
| pmid:19782030 | act(p(RGD:Stat1)) increases r(RGD:Il6) |
| pmid:19782030 | p(RGD:Pias1) increases p(RGD:Nr1h2, pmod(Sumo)) |
| pmid:19782030 | p(RGD:Nr1h2, pmod(Sumo)) increases act(p(RGD:Stat1)) |
| pmid:19782030 | p(RGD:Hdac4) increases p(RGD:Nr1h3, pmod(Sumo)) |
| pmid:19782030 | p(RGD:Nr1h3, pmod(Sumo)) increases act(p(RGD:Stat1)) |
| pmid:19323834 | complex(p(FPLX:CEBP), p(HGNC:SUMO1)) directlyDecreases r(HGNC:NOS2) |
| pmid:19323834 | p(FPLX:CEBP) partOf complex(p(FPLX:CEBP), p(HGNC:SUMO1)) |
| pmid:19323834 | p(HGNC:UBE2I) directlyDecreases r(HGNC:NOS2) |
| pmid:18675254 | p(HGNC:UBE2I) partOf complex(GO:"endoplasmic reticulum") |
| pmid:19323834 | p(HGNC:SENP1) directlyDecreases r(HGNC:NOS2) |
| pmid:18675254 | p(HGNC:APP, pmod(Sumo, Lys, 587)) decreases a(CHEBI:"amyloid-beta") |
| pmid:18675254 | p(HGNC:APP, pmod(Sumo, Lys, 595)) decreases a(CHEBI:"amyloid-beta") |
| pmid:18675254 | p(HGNC:SUMO2) increases p(HGNC:APP, pmod(Sumo, Lys, 587)) |
| pmid:18675254 | p(HGNC:SUMO2) increases p(HGNC:APP, pmod(Sumo, Lys, 595)) |
| pmid:17346237 | p(HGNC:SUMO3) increases p(HGNC:BACE1) |
| pmid:17346237 | p(HGNC:SUMO3) increases p(HGNC:APP, frag("672_711")) |
| pmid:17346237 | p(HGNC:SUMO3) increases p(HGNC:APP, frag("672_713")) |
| pmid:16464864 | a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Sumo, Lys, 340)) |
| pmid:16464864 | a(CHEBI:"okadaic acid") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| pmid:16464864 | a(CHEBI:colchicine) increases p(HGNC:MAPT, pmod(Sumo, Lys, 340)) |
| pmid:12506199 | p(HGNC:APP, pmod(Sumo)) increases a(CHEBI:"amyloid-beta") |
| pmid:12506199 | p(HGNC:APP, pmod(HBP:polysumoylation)) decreases a(CHEBI:"amyloid-beta") |
| pmid:29334120 | p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 403)) |
| pmid:29334120 | p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 404)) |
| pmid:29334120 | p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 409)) |
| pmid:29334120 | p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 410)) |
| pmid:29334120 | p(HGNC:TARDBP, pmod(Ph, Ser, 409)) increases act(p(HGNC:TARDBP)) |
| pmid:29334120 | p(HGNC:TARDBP, pmod(Ph, Ser, 410)) increases act(p(HGNC:TARDBP)) |
| pmid:26142647 | p(HGNC:PPP1R15A) regulates act(p(HGNC:PPP1CA)) |
| pmid:29228318 | a(CHEBI:"microcystin-LR") decreases p(HGNC:PPP2CA, pmod(Me)) |
| pmid:29421605 | p(RGD:Ptpn1) negativeCorrelation p(RGD:Irs1, pmod(Ph)) |
| pmid:29421605 | p(RGD:Ptpn1) negativeCorrelation p(RGD:Akt1, pmod(Ph)) |
| pmid:29421605 | p(RGD:Ptpn1) negativeCorrelation p(RGD:Gsk3b, pmod(Ph)) |
| pmid:29421605 | p(RGD:Ptpn1) negativeCorrelation p(RGD:Mtor, pmod(Ph)) |
| pmid:29421605 | p(RGD:Ptpn1) negativeCorrelation p(RGD:Ntrk2, pmod(Ph)) |
| pmid:29421605 | p(RGD:Irs1, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) |
| pmid:29421605 | p(RGD:Akt1, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) |
| pmid:29421605 | p(RGD:Gsk3b, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) |
| pmid:29421605 | p(RGD:Mtor, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) |
| pmid:29421605 | p(RGD:Ntrk2, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) |
| pmid:29062069 | p(HGNC:MID1) decreases act(p(HGNC:PPP2CA)) |
| pmid:28720530 | p(HGNC:PPP2R5E) partOf complex(GO:"protein phosphatase type 2A complex") |
| pmid:28720530 | complex(GO:"protein phosphatase type 2A complex") negativeCorrelation p(HBP:"APOE e4") |
| pmid:28422052 | a(CHEBI:"folic acid") decreases p(MGI:Mapt, pmod(Ph, Ser, 396)) |
| pmid:28422052 | a(CHEBI:"folic acid") increases p(MGI:Dnmt1) |
| pmid:28422052 | p(MGI:Dnmt1) increases p(MGI:Ppp2ca, pmod(Me, Leu, 309)) |
| pmid:28422052 | p(MGI:Ppp2ca, pmod(Me, Leu, 309)) decreases act(p(MGI:Ppp2ca)) |
| pmid:25143394 | p(MGI:Ppp1ca) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) |
| pmid:25143394 | p(MGI:Ppp1cb) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) |
| pmid:23134599 | a(CHEBI:"lead diacetate") decreases p(RGD:Ppp2ca) |
| pmid:23134599 | a(CHEBI:"lead diacetate") increases p(RGD:Ppp1ca) |
| pmid:23134599 | a(CHEBI:"lead diacetate") increases p(RGD:Ppp5c) |
| pmid:23134599 | p(RGD:Ppp2ca) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) |
| pmid:21489990 | act(p(RGD:Ppp1ca)) directlyIncreases p(RGD:Mapt, pmod(Ph, Ser, 262)) |
| pmid:21489990 | p(RGD:Egr1) directlyIncreases act(p(RGD:Cdk5)) |
| pmid:19623258 | act(complex(GO:"NMDA selective glutamate receptor complex")) positiveCorrelation p(HBP:"Tau epitope, AT8") |
| pmid:19623258 | act(complex(GO:"NMDA selective glutamate receptor complex")) positiveCorrelation p(HBP:"Tau epitope, AT180") |
| pmid:19623258 | p(HBP:"Tau epitope, AT180") positiveCorrelation act(complex(GO:"NMDA selective glutamate receptor complex")) |
| pmid:19623258 | p(HBP:"Tau epitope, AT180") equivalentTo p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| pmid:25001178 | m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:CDK5R1)) |
| pmid:25001178 | m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:CDK5), ma(kin)) |
| pmid:25001178 | m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:MAPK3), ma(kin)) |
| pmid:25001178 | m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:MAPK1), ma(kin)) |
| pmid:25001178 | m(MIRBASE:"hsa-mir-125b-1") directlyDecreases act(p(HGNC:PPP1CA)) |
| pmid:25001178 | m(MIRBASE:"hsa-mir-125b-1") directlyDecreases act(p(HGNC:DUSP6)) |
| pmid:25001178 | m(MIRBASE:"hsa-mir-125b-1") directlyDecreases act(p(HGNC:BCL2L2)) |
| pmid:25001178 | act(p(HGNC:DUSP6)) negativeCorrelation act(p(HGNC:MAPK1), ma(kin)) |
| pmid:24964035 | p(HGNC:SMAD2) decreases p(HGNC:PIN1) |
| pmid:24964035 | p(HGNC:SMAD3) decreases p(HGNC:PIN1) |
| pmid:23832849 | act(p(INTERPRO:"FKBP-type peptidyl-prolyl cis-trans isomerase domain")) directlyDecreases p(HBP:"tubulin-binding repeat 3") |
| pmid:22926167 | p(HGNC:PIN1, pmod(Ph, Ser, 16)) negativeCorrelation p(HGNC:MAPT) |
| pmid:22926167 | p(HGNC:PIN1, pmod(Ph, Ser, 16)) decreases act(p(HGNC:PIN1)) |
| pmid:22926167 | p(HGNC:PIN1, pmod(Ph, Ser, 65)) negativeCorrelation p(HGNC:MAPT) |
| pmid:22926167 | p(HGNC:PIN1, pmod(Ph, Ser, 65)) increases act(p(HGNC:PIN1)) |
| pmid:22926167 | p(HGNC:PIN1, pmod(Ac, Lys, 46)) negativeCorrelation p(HGNC:MAPT) |
| pmid:19401603 | complex(GO:"tubulin complex") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) |
| pmid:28019679 | bp(GO:"innate immune response") increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:28019679 | act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL18) |
| pmid:28019679 | act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL1B) |
| pmid:28019679 | act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL1B) |
| pmid:24561250 | complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:IL1B) |
| pmid:24561250 | complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:IL1B) |
| pmid:28019679 | complex(GO:"NLRP3 inflammasome complex") increases act(p(HGNC:CASP1)) |
| pmid:28019679 | act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:CASP1) |
| pmid:27314526 | complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:CASP1) |
| pmid:28019679 | complex(GO:"NLRP3 inflammasome complex") increases a(CHEBI:"nitric oxide") |
| pmid:28019679 | complex(GO:"NLRP3 inflammasome complex") increases sec(p(HGNC:TNF)) |
| pmid:28019679 | act(complex(GO:"NLRP3 inflammasome complex")) decreases path(MESH:"Spatial Memory") |
| pmid:28019679 | act(complex(GO:"NLRP3 inflammasome complex")) increases a(CHEBI:"amyloid-beta") |
| pmid:24561250 | complex(GO:"NLRP3 inflammasome complex") association path(MESH:"Alzheimer Disease") |
| pmid:24561250 | complex(GO:"NLRP3 inflammasome complex") increases path(MESH:"Plaque, Amyloid") |
| pmid:28019679 | a(MESH:"Toll-Like Receptors") increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:24561250 | p(HGNC:IL18) positiveCorrelation complex(GO:"inflammasome complex") |
| pmid:24561250 | p(HGNC:IL18) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27314526 | p(HGNC:IL18) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:27314526 | p(HGNC:IL18) association path(MESH:"Alzheimer Disease") |
| pmid:24561250 | p(HGNC:IL18) increases bp(GO:"inflammatory response") |
| pmid:27314526 | p(HGNC:IL18) positiveCorrelation path(MESH:Dementia) |
| pmid:27314526 | p(HGNC:IL18) increases bp(GO:"microglial cell activation") |
| pmid:27314526 | p(HGNC:IL18) increases bp(GO:"astrocyte activation") |
| pmid:27314526 | p(HGNC:IL18) increases a(CHEBI:"amyloid-beta") |
| pmid:27314526 | p(HGNC:IL18) increases p(HGNC:GSK3B) |
| pmid:27314526 | p(HGNC:IL18) increases p(HGNC:CDK5) |
| pmid:28019679 | composite(a(CHEBI:"amyloid-beta"), p(HGNC:CTSB)) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:28019679 | composite(a(CHEBI:"amyloid-beta"), p(HGNC:CD36)) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:28019679 | complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP1)) |
| pmid:23702978 | complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP1)) |
| pmid:28019679 | act(complex(GO:"NLRP1 inflammasome complex")) increases act(p(HGNC:CASP6)) |
| pmid:28019679 | act(complex(GO:"NLRP1 inflammasome complex")) increases a(CHEBI:"amyloid-beta polypeptide 42") |
| pmid:28019679 | complex(GO:"NLRP1 inflammasome complex") increases bp(GO:pyroptosis) |
| pmid:28019679 | complex(GO:"NLRP1 inflammasome complex") increases bp(HBP:HBP00027) |
| pmid:23702978 | complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP5)) |
| pmid:24561250 | complex(GO:"NLRP1 inflammasome complex") increases p(HGNC:IL1B) |
| pmid:24561250 | act(complex(GO:"NLRP1 inflammasome complex")) increases p(HGNC:IL1B) |
| pmid:24561250 | act(complex(GO:"NLRP1 inflammasome complex")) increases sec(p(HGNC:IL1B)) |
| pmid:24561250 | act(complex(GO:"NLRP1 inflammasome complex")) increases sec(p(HGNC:IL18)) |
| pmid:28019679 | a(CHEBI:"(+)-artemisinin") decreases p(MGI:Nfkbia) |
| pmid:28019679 | a(CHEBI:"(+)-artemisinin") decreases complex(GO:"NLRP3 inflammasome complex") |
| pmid:23702978 | complex(GO:"inflammasome complex") increases act(p(HGNC:IL1B)) |
| pmid:24561250 | complex(GO:"inflammasome complex") positiveCorrelation p(HGNC:IL1B) |
| pmid:24561250 | complex(GO:"inflammasome complex") increases p(HGNC:IL1B) |
| pmid:24561250 | complex(GO:"inflammasome complex") regulates p(HGNC:IL1B) |
| pmid:27314526 | complex(GO:"inflammasome complex") increases act(p(HGNC:IL1B)) |
| pmid:23702978 | complex(GO:"inflammasome complex") increases act(p(HGNC:IL18)) |
| pmid:24561250 | complex(GO:"inflammasome complex") positiveCorrelation p(HGNC:IL18) |
| pmid:24561250 | complex(GO:"inflammasome complex") increases p(HGNC:IL18) |
| pmid:24561250 | act(complex(GO:"inflammasome complex")) increases p(HGNC:IL18) |
| pmid:24561250 | complex(GO:"inflammasome complex") regulates p(HGNC:IL18) |
| pmid:27314526 | complex(GO:"inflammasome complex") increases act(p(HGNC:IL18)) |
| pmid:23702978 | complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) |
| pmid:23702978 | complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) |
| pmid:24561250 | act(complex(GO:"inflammasome complex")) increases act(p(HGNC:CASP1)) |
| pmid:27314526 | act(complex(GO:"inflammasome complex")) increases act(p(HGNC:CASP1)) |
| pmid:27314526 | complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) |
| pmid:23702978 | act(complex(GO:"inflammasome complex")) increases bp(GO:pyroptosis) |
| pmid:23702978 | complex(GO:"inflammasome complex") increases bp(GO:pyroptosis) |
| pmid:27314526 | complex(GO:"inflammasome complex") increases bp(GO:pyroptosis) |
| pmid:23702978 | complex(GO:"inflammasome complex") increases act(p(HGNC:SCAF11)) |
| pmid:27314526 | complex(GO:"inflammasome complex") increases act(p(HGNC:IL33)) |
| pmid:27314526 | complex(GO:"inflammasome complex") association path(MESH:"Alzheimer Disease") |
| pmid:23702978 | p(HGNC:PYCARD) increases complex(p(HGNC:CASP1), p(HGNC:CASP1)) |
| pmid:24561250 | p(HGNC:PYCARD) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pmid:24561250 | p(HGNC:PYCARD) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pmid:24561250 | p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) |
| pmid:24561250 | p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) |
| pmid:24561250 | p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) |
| pmid:24561250 | p(HGNC:PYCARD) increases p(HGNC:IL18) |
| pmid:24561250 | p(HGNC:PYCARD) increases p(HGNC:IL1B) |
| pmid:24561250 | p(HGNC:PYCARD) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23702978 | path(MESH:"Immune System Diseases") increases path(MESH:Atherosclerosis) |
| pmid:23702978 | path(MESH:"Immune System Diseases") increases path(MESH:"Diabetes Mellitus, Type 2") |
| pmid:23702978 | path(MESH:"Immune System Diseases") increases path(MESH:"Neurodegenerative Diseases") |
| pmid:23702978 | complex(p(HGNC:CASP1), p(HGNC:CASP1)) increases act(p(HGNC:CASP1)) |
| pmid:23702978 | bp(GO:"cell activation") increases p(HGNC:IL18) |
| pmid:24561250 | p(HGNC:NLRP1) increases p(HGNC:IL18) |
| pmid:24561250 | p(HGNC:NLRP1) increases p(HGNC:IL1B) |
| pmid:27314526 | p(HGNC:NLRP3) association a(CHEBI:"amyloid-beta") |
| pmid:27314526 | act(p(HGNC:NLRP3)) increases sec(p(HGNC:CASP1)) |
| pmid:23702978 | p(HGNC:NLRP6) increases bp(GO:"negative regulation of innate immune response") |
| pmid:23702978 | p(HGNC:NLRP12) increases bp(GO:"dendritic cell migration") |
| pmid:23702978 | p(HGNC:NLRP12) increases bp(GO:"negative regulation of NIK/NF-kappaB signaling") |
| pmid:23702978 | act(p(HGNC:NLRC4)) increases complex(p(HGNC:CFL1), p(HGNC:SCAF11)) |
| pmid:24561250 | p(HGNC:NLRC4) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:23702978 | complex(GO:"IPAF inflammasome complex") increases act(p(HGNC:CASP1)) |
| pmid:24561250 | complex(GO:"IPAF inflammasome complex") increases p(HGNC:IL1B) |
| pmid:24561250 | complex(GO:"IPAF inflammasome complex") increases sec(p(HGNC:IL1B)) |
| pmid:24561250 | act(complex(GO:"IPAF inflammasome complex")) increases sec(p(HGNC:IL1B)) |
| pmid:24561250 | complex(GO:"IPAF inflammasome complex") increases p(HGNC:IL1B) |
| pmid:24561250 | complex(GO:"IPAF inflammasome complex") association path(MESH:"Alzheimer Disease") |
| pmid:23702978 | composite(complex(GO:"NLRP1 inflammasome complex"), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1)) |
| pmid:23702978 | composite(complex(GO:"IPAF inflammasome complex"), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1)) |
| pmid:23702978 | act(p(HGNC:IFI16)) increases act(p(HGNC:TMEM173)) |
| pmid:23702978 | act(p(HGNC:DDX58)) increases act(p(HGNC:MAVS)) |
| pmid:23702978 | a(CHEBI:"RNA fragment") increases act(p(HGNC:DDX58)) |
| pmid:27314526 | a(CHEBI:"RNA fragment") increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:23702978 | act(p(HGNC:MAVS)) increases bp(GO:"response to type I interferon") |
| pmid:23702978 | a(CHEBI:"DNA polyanion") increases act(p(HGNC:IFI16)) |
| pmid:23702978 | act(p(HGNC:TMEM173)) increases bp(GO:"response to type I interferon") |
| pmid:23702978 | a(CHEBI:"muramyl dipeptide") increases act(p(HGNC:NLRP1)) |
| pmid:23702978 | complex(a(CHEBI:"muramyl dipeptide"), p(HGNC:NLRP1)) increases act(complex(GO:"inflammasome complex")) |
| pmid:23702978 | complex(p(HGNC:NLRP1), p(HGNC:NOD2)) increases act(complex(GO:"inflammasome complex")) |
| pmid:23702978 | act(p(HGNC:NAIP)) increases complex(GO:"IPAF inflammasome complex") |
| pmid:24561250 | p(HGNC:NAIP) increases act(complex(GO:"IPAF inflammasome complex")) |
| pmid:23702978 | p(HGNC:SCAF11) increases bp(GO:pyroptosis) |
| pmid:23702978 | act(p(HGNC:SCAF11)) increases bp(GO:pyroptosis) |
| pmid:23702978 | a(CHEBI:"LPS with O-antigen") increases bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") |
| pmid:23702978 | bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") regulates sec(a(MESH:"Interferon Type I")) |
| pmid:23702978 | bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases p(HGNC:SCAF11) |
| pmid:23702978 | bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases act(p(HGNC:IFNAR1)) |
| pmid:23702978 | bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases act(p(HGNC:CASP8)) |
| pmid:23702978 | a(MESH:"Interferon Type I") decreases sec(p(HGNC:IL1B)) |
| pmid:23702978 | a(MESH:"Interferon Type I") decreases sec(p(HGNC:IL18)) |
| pmid:23702978 | act(p(HGNC:IFNAR1)) increases act(p(HGNC:SCAF11)) |
| pmid:23702978 | p(HGNC:IFNAR1) increases act(p(HGNC:SCAF11)) |
| pmid:23702978 | act(p(HGNC:STAT1)) increases act(p(HGNC:SCAF11)) |
| pmid:23702978 | p(HGNC:PRTN3) increases act(p(HGNC:IL1B)) |
| pmid:23702978 | p(HGNC:IL1A) increases act(p(HGNC:IL1R1)) |
| pmid:23702978 | p(HGNC:IL1A) increases bp(GO:"inflammatory response") |
| pmid:23702978 | p(HGNC:CASP8) increases act(p(HGNC:IL1B)) |
| pmid:23702978 | act(p(HGNC:CASP8)) increases act(p(HGNC:IL1B)) |
| pmid:23702978 | act(p(HGNC:CASP8)) regulates act(p(HGNC:IL1B)) |
| pmid:23702978 | act(p(HGNC:CASP8)) regulates act(p(HGNC:IL18)) |
| pmid:23702978 | act(p(HGNC:CLEC7A)) increases act(p(HGNC:SYK)) |
| pmid:23702978 | complex(p(HGNC:CASP8), p(HGNC:MALT1)) increases complex(p(HGNC:CASP8), p(HGNC:MALT1), p(HGNC:PYCARD)) |
| pmid:23702978 | complex(p(HGNC:CASP8), p(HGNC:MALT1), p(HGNC:PYCARD)) increases act(p(HGNC:IL1B)) |
| pmid:23702978 | a(CHEBI:cycloheximide) increases bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") |
| pmid:23702978 | complex(GO:ripoptosome) increases act(p(HGNC:CASP8)) |
| pmid:23702978 | complex(GO:ripoptosome) increases act(p(HGNC:RIPK3)) |
| pmid:23702978 | p(HGNC:XIAP) decreases complex(GO:ripoptosome) |
| pmid:23702978 | p(HGNC:BIRC3) decreases complex(GO:ripoptosome) |
| pmid:23702978 | act(p(HGNC:RIPK3)) increases act(p(HGNC:IL1B)) |
| pmid:23702978 | act(p(HGNC:RIPK3)) increases act(p(HGNC:CASP1)) |
| pmid:23702978 | act(p(HGNC:RIPK3)) increases act(p(HGNC:CASP8)) |
| pmid:23702978 | p(FPLX:TNFRSF) increases p(HGNC:NLRP3) |
| pmid:23702978 | p(HGNC:BRCC3) decreases p(HGNC:NLRP3, pmod(Ub)) |
| pmid:23702978 | p(FPLX:IFNB) increases p(HGNC:AIM2) |
| pmid:23702978 | act(p(HGNC:PRKCD), ma(kin)) increases p(HGNC:NLRC4, pmod(Ph, Ser)) |
| pmid:23702978 | g(HGNC:NLRP3, var("?")) positiveCorrelation path(MESH:"Cryopyrin-Associated Periodic Syndromes") |
| pmid:24561250 | g(HGNC:NLRP3) increases a(CHEBI:"amyloid-beta") |
| pmid:24561250 | g(HGNC:NLRP3) decreases bp(GO:memory) |
| pmid:24561250 | g(HGNC:NLRP3) decreases bp(GO:behavior) |
| pmid:23702978 | path(MESH:"Cryopyrin-Associated Periodic Syndromes") positiveCorrelation g(HGNC:NLRP3, var("?")) |
| pmid:23702978 | bp(GO:"CD4-positive, alpha-beta T cell activation") decreases act(complex(GO:"NLRP1 inflammasome complex")) |
| pmid:23702978 | bp(GO:"CD4-positive, alpha-beta T cell activation") decreases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:23702978 | act(p(HGNC:NOS2)) increases a(CHEBI:"nitric oxide") |
| pmid:27314526 | act(p(HGNC:NOS2)) increases a(CHEBI:"nitric oxide") |
| pmid:23702978 | p(HGNC:NLRP3, pmod(NO)) decreases act(p(HGNC:NLRP3)) |
| pmid:23702978 | a(MESH:Interferons) increases p(HGNC:AIM2) |
| pmid:23702978 | a(MESH:Interferons) decreases p(HGNC:IL1B) |
| pmid:23702978 | a(MESH:Interferons) decreases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:23702978 | m(HGNC:MIR223) decreases p(HGNC:NLRP3) |
| pmid:23702978 | act(complex(GO:apoptosome)) increases act(p(HGNC:CASP9)) |
| pmid:23702978 | p(HGNC:MAP3K7) association a(CHEBI:"calcium(2+)") |
| pmid:23702978 | p(HGNC:TRPM2) increases act(p(HGNC:NLRP3)) |
| pmid:23702978 | act(p(HGNC:TRPM2)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) |
| pmid:23702978 | p(HGNC:CASP9, pmod(NO)) decreases act(p(HGNC:CASP9)) |
| pmid:23702978 | p(HGNC:CASP1, pmod(NO)) decreases act(p(HGNC:CASP1)) |
| pmid:23702978 | complex(p(HGNC:CARD8), p(HGNC:CASP9)) decreases act(p(HGNC:CASP9)) |
| pmid:23702978 | complex(p(HGNC:CASP1), p(MGI:Casp12)) decreases act(p(HGNC:CASP1)) |
| pmid:23702978 | p(HGNC:CARD18) decreases act(p(HGNC:CASP1)) |
| pmid:23702978 | p(HGNC:CARD16) decreases act(p(HGNC:CASP1)) |
| pmid:23702978 | p(HGNC:CARD17) decreases p(HGNC:IL1B) |
| pmid:23702978 | p(HGNC:PYDC1) decreases complex(complex(GO:"inflammasome complex"), p(HGNC:PYCARD)) |
| pmid:23702978 | p(HGNC:PYDC2) decreases complex(complex(GO:"inflammasome complex"), p(HGNC:PYCARD)) |
| pmid:23702978 | p(MGI:Mefv) decreases sec(p(MGI:Il1b)) |
| pmid:23702978 | composite(p(FPLX:HSP90), p(HGNC:SUGT1)) increases act(p(HGNC:NLRP3)) |
| pmid:24561250 | path(MESH:Stroke) increases complex(GO:"inflammasome complex") |
| pmid:24561250 | composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:NLRP2) |
| pmid:24561250 | composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:PYCARD) |
| pmid:24561250 | composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:PYCARD) |
| pmid:24561250 | composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) increases p(HGNC:IL1B) |
| pmid:24561250 | composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) increases p(HGNC:IL1B) |
| pmid:24561250 | composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:CASP1) |
| pmid:24561250 | composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) increases p(HGNC:IL18) |
| pmid:24561250 | p(HGNC:NLRP2) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pmid:24561250 | p(INTERPRO:"Leucine-rich repeat-containing adjacent domain") partOf a(MESH:"NLR Proteins") |
| pmid:24561250 | p(INTERPRO:"NACHT-associated domain") partOf a(MESH:"NLR Proteins") |
| pmid:24561250 | p(INTERPRO:"DAPIN domain") partOf p(INTERPRO:"NACHT-associated domain") |
| pmid:24561250 | p(INTERPRO:"CARD domain") partOf p(INTERPRO:"NACHT-associated domain") |
| pmid:24561250 | p(INTERPRO:"BIR repeat") partOf p(INTERPRO:"NACHT-associated domain") |
| pmid:24561250 | a(MESH:"Pathogen-Associated Molecular Pattern Molecules") increases complex(GO:"inflammasome complex") |
| pmid:24561250 | a(MESH:"Pathogen-Associated Molecular Pattern Molecules") increases act(complex(GO:"inflammasome complex")) |
| pmid:24561250 | a(MESH:Alarmins) increases complex(GO:"inflammasome complex") |
| pmid:24561250 | a(MESH:Alarmins) increases act(complex(GO:"inflammasome complex")) |
| pmid:24561250 | complex(a(MESH:"NLR Proteins"), p(INTERPRO:"NACHT-associated domain")) increases complex(GO:"inflammasome complex") |
| pmid:24561250 | complex(p(HGNC:CASP1), p(HGNC:NLRP1), p(HGNC:PYCARD)) increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pmid:24561250 | complex(p(HGNC:CASP1), p(HGNC:NLRP3), p(HGNC:PYCARD)) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:24561250 | a(MESH:Bacteria) increases act(complex(GO:"inflammasome complex")) |
| pmid:24561250 | a(MESH:Viruses) increases act(complex(GO:"inflammasome complex")) |
| pmid:24561250 | a(MESH:Fungi) increases act(complex(GO:"inflammasome complex")) |
| pmid:24561250 | a(MESH:RNA) increases act(complex(GO:"inflammasome complex")) |
| pmid:24561250 | a(CHEBI:"potassium aluminium sulfate") increases act(complex(GO:"inflammasome complex")) |
| pmid:24561250 | a(CHEBI:"fatty acid") increases act(complex(GO:"inflammasome complex")) |
| pmid:24561250 | deg(a(MESH:"DNA, Mitochondrial")) increases act(complex(GO:"inflammasome complex")) |
| pmid:24561250 | path(MESH:"Spinal Cord Injuries") increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pmid:24561250 | path(MESH:"Spinal Cord Injuries") increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pmid:24561250 | path(MESH:"Spinal Cord Injuries") increases sec(p(HGNC:IL18)) |
| pmid:24561250 | path(MESH:"Spinal Cord Injuries") increases sec(p(HGNC:IL1B)) |
| pmid:24561250 | path(MESH:"Spinal Cord Injuries") increases a(CHEBI:ATP) |
| pmid:24561250 | p(HGNC:P2RX7) increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pmid:24561250 | p(HGNC:P2RX7) increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pmid:27314526 | act(p(HGNC:P2RX7)) increases bp(GO:"inflammatory response") |
| pmid:27314526 | act(p(HGNC:P2RX7)) increases bp(GO:"apoptotic process") |
| pmid:27314526 | act(p(HGNC:P2RX7)) increases bp(GO:"cell proliferation") |
| pmid:27314526 | p(HGNC:P2RX7) increases act(complex(GO:"NLRP3 inflammasome complex")) |
| pmid:27314526 | p(HGNC:P2RX7) positiveCorrelation path(MESH:"Alzheimer Disease") |
| pmid:24561250 | p(MGI:P2rx4) increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pmid:24561250 | p(MGI:P2rx4) increases p(HGNC:IL1B) |
| pmid:24561250 | p(MGI:P2rx4) increases p(HGNC:IL1B) |
| pmid:24561250 | p(MGI:P2rx4) increases act(complex(GO:"inflammasome complex")) |
| pmid:24561250 | p(MGI:P2rx7) increases act(complex(GO:"NLRP1 inflammasome complex")) |
| pmid:24561250 | composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2), p(HGNC:P2RX7), p(HGNC:PANX1)) increases p(HGNC:IL1B) |
| pmid:24561250 | p(HGNC:PANX1) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pmid:24561250 | p(HGNC:PANX1) increases p(HGNC:IL1B) |
| pmid:24561250 | p(HGNC:PANX1) increases p(HGNC:IL18) |
| pmid:24561250 | a(CHEBI:hexadecanoate) increases complex(GO:"IPAF inflammasome complex") |
| pmid:24561250 | a(CHEBI:hexadecanoate) increases act(complex(GO:"IPAF inflammasome complex")) |
| pmid:24561250 | p(MGI:Nlrp3) increases p(MGI:Il1b) |
| pmid:24561250 | p(MGI:Nlrp3) increases bp(GO:"amyloid-beta formation") |
| pmid:24561250 | p(MGI:Nlrp3) increases a(MESH:Neuropathology) |
| pmid:24561250 | p(MGI:Nlrp3) decreases bp(GO:cognition) |
| pmid:24561250 | composite(a(CHEBI:hexadecanoate), p(HGNC:PYCARD)) increases p(HGNC:IL1B) |
| pmid:24561250 | composite(a(CHEBI:hexadecanoate), p(HGNC:NLRC4)) increases p(HGNC:IL1B) |
| pmid:24561250 | a(CHEBI:"saturated fatty acid") increases p(HGNC:IL1B) |
| pmid:24561250 | a(CHEBI:probenecid) decreases p(HGNC:PANX1) |
| pmid:24561250 | a(CHEBI:probenecid) decreases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pmid:24561250 | a(CHEBI:probenecid) decreases p(HGNC:IL1B) |
| pmid:24561250 | a(CHEBI:probenecid) decreases p(HGNC:IL18) |
| pmid:24561250 | a(CHEBI:probenecid) decreases act(complex(GO:"NLRP1 inflammasome complex")) |
| pmid:24561250 | a(CHEBI:probenecid) increases bp(GO:learning) |
| pmid:24561250 | a(PUBCHEM:6324599) decreases act(p(HGNC:P2RX7)) |
| pmid:24561250 | a(PUBCHEM:6324599) decreases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) |
| pmid:24561250 | p(MGI:Casp1) increases bp(GO:"amyloid-beta formation") |
| pmid:24561250 | p(MGI:Casp1) increases a(MESH:Neuropathology) |
| pmid:24561250 | p(MGI:Casp1) decreases bp(GO:cognition) |
| pmid:27314526 | sec(a(MESH:Interleukins)) association path(MESH:Dementia) |
| pmid:27314526 | sec(a(MESH:Interleukins)) association bp(HBP:neuroinflammation) |
| pmid:27314526 | bp(GO:"cytokine secretion") increases bp(GO:"inflammatory response") |
| pmid:27314526 | act(p(HGNC:PRSS3)) increases p(HGNC:IL18) |
| pmid:27314526 | act(p(FPLX:ELA)) increases p(HGNC:IL18) |
| pmid:27314526 | act(p(HGNC:CTSG)) increases p(HGNC:IL18) |
| pmid:27314526 | composite(complex(GO:"NLRP3 inflammasome complex"), p(HGNC:CASP1), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1)) |
| pmid:27314526 | path(MESH:Periodontitis) decreases bp(GO:cognition) |
This section lists all of the namespaces that are defined in the original BEL document.
The source BEL document contained references to the following namespaces, but they were never used. It is suggested to delete their definitions from the BEL document to improve readability and parsing speed.
This section lists all of the annotations that are defined in the original BEL document.
The source BEL document contained references to the following annotations, but they were never used. It is suggested to delete their definitions from the BEL document to improve readability and parsing speed.
Note: this may be due to errors occurring in all statements with these annotations.
The source BEL document contained annotations defined as a list. Click each link to export
the list definition as a BELANNO file that can hosted externally to promote
re-usability and interoperability. After, you can replace the list definition in the source
BEL with a SET ANNOTATION X AS URL "Y" definition.
The source BEL document contained the following list annotations, but no references to the following values. It is suggested to prune these values from the list definitions.
Note: this may be due to errors occurring in all statements with these annotations.
| Annotation | Values |
|---|---|
| ExpGroup |
|
| HasQuantitativeInformation |
|
| Km_ATP |
|
| MeasurementType |
|
| MeasurementValue |
|
| Method |
|
| PublicationType |
|
| Research_Model |
|
| Tau_Epitope |
|
| Vmax |
|
| Error | Frequency |
|---|---|
"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace |
5 |
"Nitrosative Stress" is not in the MESH namespace |
4 |
"neuroinflammatory response" is not in the GO namespace |
4 |
"Tau antibody, CP13" is not in the HBP namespace |
2 |
"soluble tau" is not in the HBP namespace |
2 |
"3-3' dityrosine cross-linking" is not in the HBP namespace |
2 |
"CA1 interneuron" is not in the HBP namespace |
2 |
| Path | Line | BEL | Message |
|---|---|---|---|
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel | 142 | complex(p(MGI:Mapt, pmod(Ph)), p(HBP:"Tau antibody, PHF1"))) |
"Tau antibody, PHF1" is not in the HBP namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel | 143 | complex(p(MGI:Mapt, pmod(Ph)), p(HBP:"Tau antibody, CP13"))) |
"Tau antibody, CP13" is not in the HBP namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel | 145 | p(MGI:Tfeb) cnc p(MGI:Cp13) |
"Cp13" is not in the MGI namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel | 148 | complex(p(MGI:Mapt, pmod(Ph)), p(HBP:"Tau antibody, AT8"))) |
"Tau antibody, AT8" is not in the HBP namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel | 149 | complex(p(MGI:Mapt, pmod(Ph)), p(HBP:"Tau antibody, AT180"))) |
"Tau antibody, AT180" is not in the HBP namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel | 150 | complex(p(MGI:Mapt, pmod(Ph)), p(HBP:"Tau antibody, CP13"))) |
"Tau antibody, CP13" is not in the HBP namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel | 154 | p(MGI:Tfeb) -| p(HBP:"soluble tau",pmod(Ph)) |
"soluble tau" is not in the HBP namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel | 155 | p(MGI:Tfeb) cnc p(HBP:"soluble tau") |
"soluble tau" is not in the HBP namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel | 167 | complex(p(HBP:"Tau antibody,MC1")) |
"Tau antibody,MC1" is not in the HBP namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel | 111 | p(HBP:"tubulin-binding repeat 1") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat") |
"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel | 112 | p(HBP:"tubulin-binding repeat 2") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat") |
"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel | 113 | p(HBP:"tubulin-binding repeat 3") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat") |
"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel | 114 | p(HBP:"tubulin-binding repeat 4") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat") |
"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel | 134 | p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat", pmod(Ph)) -| complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) |
"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 616 | a(CHEBI:"amyloid-beta") -> bp(MESH:"Nitrosative Stress") |
"Nitrosative Stress" is not in the MESH namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 617 | bp(MESH:"Nitrosative Stress") pos p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) |
"Nitrosative Stress" is not in the MESH namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 618 | bp(MESH:"Nitrosative Stress") pos p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) |
"Nitrosative Stress" is not in the MESH namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 860 | a(CHEBI:peroxynitrite) -> bp(MESH:"Nitrosative Stress") |
"Nitrosative Stress" is not in the MESH namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 928 | a(CHEBI:peroxynitrite) -> a(HBP:"3-3' dityrosine cross-linking") |
"3-3' dityrosine cross-linking" is not in the HBP namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 929 | a(HBP:"3-3' dityrosine cross-linking") pos a(HBP:"paired helical filaments") |
"3-3' dityrosine cross-linking" is not in the HBP namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 1496 | p(MGI:Ttbk1) -> bp(GO:"neuroinflammatory response") |
"neuroinflammatory response" is not in the GO namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 1870 | act(p(MGI:Dapk1)) neg tloc(a(CHEBI:neurotransmitter), fromLoc(HBP:"entorhinal cortex layer 2"), toLoc(HBP:"CA1 interneuron")) |
"CA1 interneuron" is not in the HBP namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 1871 | tloc(a(CHEBI:neurotransmitter), fromLoc(HBP:"entorhinal cortex layer 2"), toLoc(HBP:"CA1 interneuron")) pos bp(GO:memory) |
"CA1 interneuron" is not in the HBP namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 2486 | act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) pos a(HBP:"long-term depression") |
"long-term depression" is not in the HBP namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 2954 | a(CHEBI:lipopolysaccharide) -> bp(GO:"neuroinflammatory response") |
"neuroinflammatory response" is not in the GO namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 2955 | a(CHEBI:"amyloid-beta") -> bp(GO:"neuroinflammatory response") |
"neuroinflammatory response" is not in the GO namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 2956 | a(HBP:"C-30-27") -| bp(GO:"neuroinflammatory response") |
"neuroinflammatory response" is not in the GO namespace |
| /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel | 3404 | a(HBP:MPT0G211) -> p(HBP:"Blood-Brain Barrier") |
"Blood-Brain Barrier" is not in the HBP namespace |
These pairs of nodes represent motifs like A increases B and
B decreases A.
| Node A | Node B |
|---|---|
| p(HGNC:CHRNA7) | a(CHEBI:anandamide) |
| complex(GO:"proteasome complex") | a(CHEBI:"amyloid-beta") |
| a(CHEBI:"amyloid-beta") | path(MESH:"Alzheimer Disease") |
| p(HGNC:CHRNA7) | complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) |
| p(HGNC:TNF) | a(CHEBI:nicotine) |
| a(MESH:Neurons) | p(HGNC:MAPT) |
| bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") | p(HGNC:MAPT) |
| p(HGNC:MAPT) | bp(HP:Neurodegeneration) |
| p(HGNC:PIN1) | p(HGNC:SMAD2) |
| p(MGI:Mapt, var("p.Pro301Leu")) | bp(GO:macroautophagy) |
| p(HGNC:CHRNA7) | a(CHEBI:"amyloid-beta") |
| bp(GO:autophagy) | p(HGNC:HTT, var("?")) |
| bp(GO:autophagy) | p(HGNC:MAPT) |
| path(MESH:Tauopathies) | p(MGI:Tfeb) |
| a(CHEBI:"amyloid-beta polypeptide 42") | p(HGNC:AK1) |
| a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA7) |
| bp(GO:"late endosomal microautophagy") | p(MGI:Mapt) |
These pairs of nodes have a contradiction in their causal relationships, meaning they
have more than one of INCREASES, DECREASES, or CAUSES NO
CHANGE. This may be due to different experimental conditions, so these statements
need to be carefully considered in analyses.
| Source | Relations | Target |
|---|---|---|
| a(PUBCHEM:11249342) | increases, causesNoChange | path(MESH:Vomiting) |
| a(CHEBI:chloroquine) | increases, decreases | p(HGNC:MAPT) |
| p(HGNC:ABCB1) | increases, decreases | a(CHEBI:"amyloid-beta") |
| a(CHEBI:donepezil) | increases, decreases | p(HGNC:ACHE) |
| a(CHEBI:"Hsp90 inhibitor") | increases, decreases | p(HGNC:MAPT) |
| a(CHEBI:rivastigmine) | increases, decreases | p(HGNC:ACHE) |
| p(HGNC:APOE) | increases, decreases, regulates | a(CHEBI:"amyloid-beta") |
| a(GO:"neurofibrillary tangle") | increases, decreases | bp(GO:"cell death") |
| bp(MESH:"Heat-Shock Response") | increases, causesNoChange | p(NCBIGENE:492507) |
| a(MESH:"SNARE Proteins") | increases, causesNoChange | p(HGNC:CHRNA7) |
| path(MESH:"Alzheimer Disease") | association, decreases, increases, negativeCorrelation | p(HGNC:CHRNA7) |
| p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) | decreases, causesNoChange, negativeCorrelation | a(MESH:Microglia) |
| p(MGI:Chrna7) | increases, decreases | path(MESH:"Spatial Memory") |
| a(HBP:HBP00055) | increases, decreases | p(MGI:Mapt) |
| a(PUBCHEM:675434) | increases, decreases | p(HGNC:MAPT) |
| a(MESH:antalarmin) | decreases, causesNoChange | path(HBP:"isolation rearing") |
| a(MESH:antalarmin) | increases, decreases | p(RGD:Drd3) |
| a(CHEBI:nicotine) | association, regulates, increases, causesNoChange, decreases | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| a(CHEBI:nifedipine) | increases, causesNoChange | bp(GO:"calcium-mediated signaling") |
| p(MGI:Mapt, var("p.Pro301Leu")) | increases, decreases | p(MGI:Mapt) |
| p(HGNC:BCHE) | decreases, directlyIncreases | a(CHEBI:acetylcholine) |
| p(HGNC:TFEB) | increases, decreases, regulates | a(CHEBI:"amyloid-beta") |
| a(HBP:"amyloid-beta oligomers") | increases, decreases | p(HGNC:MAPT) |
| p(MGI:Chrna7) | increases, decreases | a(CHEBI:"amyloid-beta") |
| p(HGNC:BSG) | decreases, causesNoChange | a(CHEBI:"amyloid-beta") |
| a(MESH:antalarmin) | increases, decreases | p(RGD:Drd2) |
| p(HGNC:WNT3A) | increases, decreases | a(CHEBI:"amyloid-beta") |
| p(HGNC:TTBK2, var("p.Tyr448*")) | increases, decreases | p(HGNC:TTBK2) |
| a(CHEBI:"amyloid-beta") | association, positiveCorrelation, increases, causesNoChange, decreases | p(HGNC:CHRNA7) |
| complex(a(HBP:"Tau oligomers"), p(HGNC:HSPA1A)) | increases, decreases | bp(GO:"anterograde axonal protein transport") |
| bp(MESH:Autophagy) | increases, decreases | a(HBP:"Tau aggregates") |
| p(HGNC:TNF) | increases, causesNoChange | p(HGNC:STAT3, pmod(Ph)) |
| p(FPLX:mTORC1) | increases, decreases | p(HGNC:TFEB) |
| p(HGNC:TTBK2, var("p.Asp449*")) | increases, decreases | p(HGNC:TTBK2) |
| a(HBP:HBP00092) | increases, causesNoChange | bp(GO:"apoptotic process") |
| a(HBP:"4-OH-GTS-21") | decreases, causesNoChange | a(MESH:"Cholinergic Neurons") |
| p(HGNC:CHRM1) | increases, causesNoChange | bp(GO:"ERK1 and ERK2 cascade") |
| p(MGI:Vegfc) | increases, causesNoChange | a(MESH:"Lymphatic Vessels") |
| a(CHEBI:Thrombin) | increases, causesNoChange | p(HGNC:MAPT, frag("561_685")) |
| p(HGNC:ACE) | increases, decreases | a(CHEBI:"amyloid-beta") |
| path(HBP:"isolation rearing") | increases, decreases | r(RGD:Bdnf) |
| p(MGI:Chrna7) | increases, decreases | p(MGI:Map2) |
| p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) | increases, causesNoChange | p(MGI:Mapt) |
| path(MESH:"Alzheimer Disease") | association, increases, causesNoChange, positiveCorrelation | p(HGNC:MAPT) |
| path(HBP:"isolation rearing") | increases, decreases | r(RGD:Ntrk2) |
| a(CHEBI:nicotine) | increases, decreases | p(HBP:"alpha-4 beta-2 nAChR") |
| a(PUBCHEM:11249342) | increases, causesNoChange | path(MESH:Nausea) |
| a(MESH:Liver) | increases, decreases | a(CHEBI:"amyloid-beta") |
| bp(GO:macroautophagy) | increases, decreases | p(MGI:Mapt) |
| p(FPLX:mTORC1) | increases, decreases | bp(GO:macroautophagy) |
| a(CHEBI:Anatabine) | decreases, causesNoChange | bp(HBP:Astrogliosis) |
| a(MESH:Nicotine) | increases, decreases | complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| a(CHEBI:epoxomicin) | increases, decreases | p(HGNC:MAPT) |
| a(PUBCHEM:675434) | increases, causesNoChange | p(FPLX:Proteasome) |
| p(MGI:Crh) | decreases, causesNoChange | a(MESH:Progesterone) |
| p(HGNC:CHRNA7) | increases, decreases, regulates | a(CHEBI:"glutamate(2-)") |
| p(HGNC:BACE1, frag("228_236")) | increases, decreases | a(HBP:"sAPP-alpha") |
| p(MGI:Vegfc) | increases, causesNoChange | a(CHEBI:macromolecule) |
| p(HGNC:BACE1, frag("67_78")) | increases, decreases | a(HBP:"sAPP-alpha") |
| a(CHEBI:"chondroitin sulfate") | decreases, causesNoChange | a(HBP:"Tau isoform F (441 aa)") |
| a(CHEBI:nicotine) | increases, causesNoChange, regulates | p(FPLX:CHRN) |
| bp(GO:macroautophagy) | decreases, causesNoChange | p(MGI:Mapt, var("p.Pro301Leu")) |
| p(HGNC:HSPA1A) | increases, decreases | a(HBP:"Tau aggregates") |
| a(CHEBI:galanthamine) | increases, decreases | p(HGNC:ACHE) |
| a(MESH:Nicotine) | increases, decreases | p(MESH:"Receptors, GABA") |
| p(HGNC:CHRNA7) | increases, decreases, positiveCorrelation, association | a(CHEBI:"amyloid-beta") |
| p(HGNC:BACE1) | association, increases, causesNoChange, decreases | p(HGNC:APP) |
| a(MESH:Neurons) | increases, causesNoChange | p(HGNC:MAPT) |
| a(CHEBI:rosiglitazone) | increases, decreases | a(CHEBI:"amyloid-beta") |
| a(CHEBI:rosiglitazone) | decreases, causesNoChange | a(HBP:HBP00018) |
| a(MESH:antalarmin) | increases, causesNoChange | a(MESH:"Embryonic Structures") |
| complex(a(GO:"proteasome complex"), p(HGNC:USP14)) | increases, decreases | bp(GO:"protein catabolic process") |
| bp(MESH:Autophagy) | increases, decreases | p(HBP:"Tau C3") |
| a(CHEBI:"amyloid-beta") | increases, decreases | a(CHEBI:acetylcholine) |
| a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") | increases, decreases | bp(HP:Neurodegeneration) |
| a(CHEBI:"methylene blue") | increases, decreases | p(HGNC:MARK4) |
| p(HGNC:TTBK2, var("p.Glu450*")) | increases, decreases | p(HGNC:TTBK2) |
| a(CHEBI:nicotine) | increases, decreases, regulates | a(CHEBI:dopamine) |
| p(HGNC:AQP4) | increases, decreases, association | a(CHEBI:"amyloid-beta") |
| p(HGNC:IDE) | increases, decreases | a(CHEBI:"amyloid-beta") |
| a(MESH:antalarmin) | increases, decreases | r(RGD:Ntrk2) |
| a(CHEBI:Anatabine) | decreases, causesNoChange | p(MGI:Tnf) |
| a(CHEBI:nicotine) | increases, causesNoChange | a(HBP:"alpha-4-containing nAChR") |
| path(MESH:"Alzheimer Disease") | association, positiveCorrelation, increases, decreases, negativeCorrelation | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| p(HGNC:ACHE) | increases, decreases, directlyIncreases | a(CHEBI:acetylcholine) |
| p(MGI:Tfeb) | decreases, causesNoChange | p(MGI:Mapt, pmod(Ph)) |
| a(CHEBI:"amyloid-beta") | increases, decreases | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| p(HGNC:HSPB1) | increases, decreases, causesNoChange | p(HGNC:MAPT) |
| a(CHEBI:"amyloid-beta") | increases, decreases | complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| p(HGNC:CHAT) | increases, decreases, directlyIncreases | a(CHEBI:acetylcholine) |
| bp(MESH:Aging) | increases, decreases | p(FPLX:HSP90) |
| path(MESH:"Alzheimer Disease") | association, decreases, increases, positiveCorrelation | a(CHEBI:"amyloid-beta") |
| a(CHEBI:"amyloid-beta polypeptide 42") | decreases, causesNoChange | p(ECCODE:"2.7.11.31") |
| path(MESH:D000544) | decreases, causesNoChange | p(HGNC:ACHE) |
| a(CHEBI:ambroxol) | increases, decreases | p(HGNC:SNCA) |
| a(MESH:Nicotine) | increases, decreases | p(HGNC:CHRNA7) |
| p(HGNC:MAPT) | increases, decreases | a(MESH:Neurons) |
| a(MESH:Kidney) | increases, decreases | a(CHEBI:"amyloid-beta") |
| bp(MESH:Autophagy) | increases, causesNoChange | p(HGNC:MAPT) |
| a(CHEBI:"amyloid-beta") | increases, decreases | bp(GO:memory) |
| path(MESH:D060825) | increases, causesNoChange | p(HGNC:CHAT) |
| p(MGI:Mapt, var("p.Ala152Thr")) | increases, decreases | p(MGI:Mapt) |
| a(CHEBI:lactacystin) | increases, decreases | p(HGNC:MAPT) |
| bp(GO:"chaperone-mediated autophagy") | increases, causesNoChange | p(MGI:Mapt, var("p.Pro301Leu")) |
| p(HGNC:PICALM) | increases, decreases | a(CHEBI:"amyloid-beta") |
| p(HGNC:PRKN, var("?")) | increases, decreases | p(HGNC:PRKN) |
| a(CHEBI:Anatabine) | decreases, causesNoChange | p(MGI:Ifng) |
| a(HBP:"amyloid-beta oligomers") | increases, decreases | p(HGNC:DLG4) |
| p(HGNC:CDC37) | increases, decreases | p(HGNC:MAPT) |
A increases
B and B increases A.
A decreases
B and B decreases A.
While neither chaotic nor dampened pairs are biologically invalid, they require additional context to understand their regulation.
| Type | Node A | Node B |
|---|---|---|
| Chaotic | p(HGNC:ERN1) | p(HGNC:ERN1, pmod(Ph)) |
| Chaotic | a(MESH:Neurons) | p(HGNC:MAPT) |
| Chaotic | a(CHEBI:"amyloid-beta") | path(MESH:"Alzheimer Disease") |
| Chaotic | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Chaotic | bp(GO:"microglial cell activation") | p(HGNC:IL1B) |
| Chaotic | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) |
| Chaotic | p(HBP:"N-terminal fragment of ATF6") | p(HBP:"N-terminal fragment of ATF6") |
| Chaotic | p(HGNC:MAPT, var("p.Pro301Ser")) | p(HGNC:MAPT, var("p.Pro301Ser")) |
| Chaotic | a(CHEBI:acetylcholine) | complex(a(CHEBI:acetylcholine), p(MESH:D011950)) |
| Chaotic | a(CHEBI:acetylcholine) | p(HGNC:CHRM1) |
| Chaotic | a(MESH:"Lymphatic Vessels") | p(MGI:Vegfc) |
| Chaotic | a(MESH:"Neurofibrillary Tangles") | p(HGNC:MAPT) |
| Chaotic | bp(GO:"chaperone-mediated autophagy") | p(MGI:Mapt, var("p.Pro301Leu")) |
| Chaotic | bp(GO:"depolarization of postsynaptic membrane") | bp(GO:"long-term synaptic potentiation") |
| Chaotic | a(CHEBI:nicotine) | p(HGNC:CHRNA7) |
| Chaotic | a(CHEBI:"amyloid-beta") | complex(GO:"NLRP3 inflammasome complex") |
| Chaotic | a(CHEBI:acetylcholine) | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| Chaotic | complex(GO:"filamentous actin") | p(HGNC:MAPT) |
| Chaotic | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:MMP3) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(FPLX:TLR) |
| Chaotic | a(CHEBI:acetylcholine) | bp(GO:"synaptic transmission, cholinergic") |
| Chaotic | p(HGNC:PRNP) | p(HGNC:PRNP) |
| Chaotic | a(HBP:"Tau isoform F (441 aa)") | a(HBP:"Tau isoform F (441 aa)") |
| Chaotic | a(CHEBI:acetylcholine) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Chaotic | a(CHEBI:"amyloid-beta") | bp(GO:phagocytosis) |
| Chaotic | a(CHEBI:nicotine) | p(FPLX:PI3K) |
| Chaotic | bp(GO:"microglial cell activation") | p(HGNC:IL18) |
| Chaotic | bp(GO:macroautophagy) | p(MGI:Mapt, var("p.Ala152Thr")) |
| Chaotic | a(CHEBI:nicotine) | bp(GO:"ERK1 and ERK2 cascade") |
| Chaotic | a(CHEBI:"calcium(2+)") | p(HGNC:CHRNA7) |
| Chaotic | p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")) | p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")) |
| Chaotic | complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) | p(HGNC:MAPT, pmod(Ph)) |
| Chaotic | a(CHEBI:nicotine) | p(FPLX:"CAMK2_complex") |
| Chaotic | a(MESH:"Lymphatic Vessels") | bp(MESH:"Cerebrovascular Circulation") |
| Chaotic | complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) | p(HGNC:CDK5) |
| Chaotic | complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) | p(HGNC:UBA2) |
| Chaotic | a(MESH:Proteins) | p(HGNC:PSMD14) |
| Chaotic | p(HGNC:HSF1) | p(HGNC:HSF1) |
| Chaotic | bp(GO:"apoptotic process") | p(HGNC:CASP6) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:MMP9) |
| Chaotic | a(HBP:"Tau oligomers") | p(HGNC:MAPT) |
| Chaotic | bp(GO:"astrocyte activation") | p(HGNC:IL18) |
| Chaotic | a(CHEBI:acetylcholine) | a(CHEBI:choline) |
| Chaotic | bp(GO:"astrocyte activation") | p(HGNC:IL1B) |
| Chaotic | a(CHEBI:dextran) | a(CHEBI:dextran) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:MMP2) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA7) |
| Chaotic | a(CHEBI:"calcium(2+)") | a(CHEBI:"calcium(2+)") |
| Chaotic | bp(GO:"chaperone-mediated autophagy") | p(MGI:Mapt, var("p.Ala152Thr")) |
| Chaotic | a(CHEBI:"amyloid-beta polypeptide 42") | p(HGNC:TREM2) |
| Dampened | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) |
| Dampened | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) |
| Dampened | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:nicotine) |
| Dampened | p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) | p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) |
| Dampened | p(MGI:Mapt, var("p.Ala152Thr")) | p(MGI:Mapt, var("p.Ala152Thr")) |
| Dampened | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) |
| Dampened | p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) | p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) |
| Dampened | p(HBP:HBP00053, var("p.Lys280del")) | p(HBP:HBP00053, var("p.Lys280del")) |
| Dampened | complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) | complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) |
| Dampened | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") |
| Dampened | p(HBP:"cis p-tau") | p(HBP:"cis p-tau") |
| Dampened | a(CHEBI:"amyloid-beta") | complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) |
| Dampened | a(HBP:"protein aggregates") | bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") |
| Dampened | a(CHEBI:"amyloid-beta") | p(HGNC:CHRM1) |
| Dampened | p(HBP:"cis p-tau") | p(HGNC:PIN1) |
| Dampened | p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) | p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| Dampened | p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) | p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) |
| Dampened | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA7) |
| Dampened | p(MGI:Mapt, var("p.Pro301Leu")) | p(MGI:Mapt, var("p.Pro301Leu")) |
Analysis of triple stability comes from a deep graph theoretic background. It identifies triangles within the graph that have logically inconsistent relations.
A positiveCorrelation B, B negativeCorrelation
C, but C positiveCorrelation A.
A negativeCorrelation B, B negativeCorrelation
C, and C negativeCorrelation A.
A increases B, A decreases C, and C
positiveCorrelation A.
A increases B, A increases C, and C
negativeCorrelation A.
A decreases B, A decreases C, and C
negativeCorrelation A.
| Type | Node A | Node B | Node C |
|---|---|---|---|
| Separate | p(HGNC:MAPT) | p(HGNC:MAPT) | p(HGNC:PIN1, pmod(Ph, Ser, 71)) |
| Separate | p(HGNC:MAPT) | p(HGNC:MAPT) | p(HGNC:PIN1, pmod(Ph, Ser, 71)) |
| Separate | path(MESH:"Alzheimer Disease") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| Separate | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | p(HGNC:CHRNA4) | path(MESH:"Alzheimer Disease") |
| Separate | path(MESH:"Pick Disease of the Brain") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) |
| Separate | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA4) | path(MESH:"Alzheimer Disease") |
| Separate | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA7) | path(MESH:"Alzheimer Disease") |
| Separate | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | p(HGNC:CHRNA7) | path(MESH:"Alzheimer Disease") |
| Separate | path(MESH:"Alzheimer Disease") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) |
| Separate | path(MESH:"Alzheimer Disease") | p(HGNC:BAG1) | p(HGNC:MAPT, pmod(Ph)) |
| Separate | path(MESH:"Pick Disease of the Brain") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) |
| Separate | path(MESH:"Alzheimer Disease") | bp(GO:"neuron death") | bp(MESH:Autophagy) |
| Separate | path(MESH:"Alzheimer Disease") | bp(GO:aging) | p(HGNC:MAPT) |
| Separate | p(HGNC:MAPT) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ub)) |
| Separate | p(HGNC:MAPT) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ub)) |
| Mutual | bp(GO:aging) | complex(GO:"proteasome complex") | p(HGNC:MAPT) |
| Jens | a(CHEBI:"dimethyl fumarate") | p(FPLX:ERK) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:acetylcholine) | a(CHEBI:choline) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(FPLX:TLR) |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:"Cholinesterase Inhibitors") | path(MESH:"Alzheimer Disease") |
| Jens | complex(GO:"neuron projection") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:donepezil) | p(HGNC:LRP1) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT) | p(HGNC:PIN1, pmod(Ph, Ser, 71)) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | bp(GO:aging) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:IDE) |
| Jens | a(CHEBI:Thrombin) | a(HBP:"Tau aggregates") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:"calcium(2+)") | p(HGNC:CHRNA7) |
| Jens | p(HGNC:CTSD) | p(HGNC:MAPT) | path(MESH:"Frontotemporal Dementia") |
| Jens | a(CHEBI:Temsirolimus) | bp(GO:autophagy) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:acetylcholine) | a(MESH:"Receptors, Nicotinic") |
| Jens | p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) | p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) | p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) |
| Jens | a(CHEBI:acetylcholine) | p(HGNC:BCHE) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CHRNA4) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"methylene blue") | bp(MESH:Autophagy) | p(HGNC:MAPT) |
| Jens | a(GO:"late endosome") | p(MGI:Mapt) | p(MGI:Mapt, var("p.Ala152Thr")) |
| Jens | a(HBP:"Corticobasal Degeneration") | a(HBP:"Tau oligomers") | a(HBP:"Tau oligomers") |
| Jens | a(CHEBI:"calcium(2+)") | p(HGNC:MAPT) | p(HGNCGENEFAMILY:Calpains) |
| Jens | p(HBP:"N-terminal fragment of ATF6") | p(HBP:"N-terminal fragment of ATF6") | p(HBP:"N-terminal fragment of ATF6") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"cell death") | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:Thrombin) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:ADAM10) | p(HGNC:APP) |
| Jens | p(HGNC:FYN) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | p(MESH:Neprilysin) | path(MESH:"Alzheimer Disease") |
| Jens | p(MGI:Mapt, var("p.Ala152Thr")) | p(MGI:Mapt, var("p.Ala152Thr")) | p(MGI:Mapt, var("p.Ala152Thr")) |
| Jens | a(HBP:"Tau aggregates") | bp(MESH:Autophagy) | p(HBP:"Tau C3") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"MAPK cascade") | p(HGNC:CHRM1) |
| Jens | bp(GO:"chaperone-mediated autophagy") | p(MGI:Mapt, var("p.Pro301Leu")) | p(MGI:Mapt, var("p.Pro301Leu")) |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(GO:"neurofibrillary tangle") | a(HBP:"Tau aggregates") | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) |
| Jens | p(HGNC:DAPK1) | p(HGNC:MAPT) | p(HGNC:PIN1, pmod(Ph, Ser, 71)) |
| Jens | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:IL18) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CASP3) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau oligomers") | path(MESH:Tauopathies) |
| Jens | p(HGNC:IL18) | p(HGNC:PYCARD) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:galanthamine) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:nicotine) | a(MESH:"Dopaminergic Neurons") | p(FPLX:CHRN) |
| Jens | bp(GO:"proteasomal protein catabolic process") | p(HGNC:HSPB1) | p(HGNC:MAPT) |
| Jens | p(HGNC:CDC37) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| Jens | p(HGNC:HSPB1) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:ABCB1) |
| Jens | a(CHEBI:nicotine) | a(MESH:"Dopaminergic Neurons") | p(HBP:"alpha-4 beta-2 nAChR") |
| Jens | a(CHEBI:"amyloid-beta") | a(GO:lysosome) | complex(GO:"NLRP3 inflammasome complex") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA7) |
| Jens | a(MESH:"Amyloid beta-Peptides") | p(HGNC:APP) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"methylene blue") | bp(GO:autophagy) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(HBP:"Tau oligomers") | p(HGNC:MAPT) | path(MESH:"Brain Injuries, Traumatic") |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) | bp(GO:memory) |
| Jens | a(HBP:"amyloid-beta oligomers") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | bp(GO:phagocytosis) | p(HGNC:TREM2) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | bp(GO:memory) |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) | a(CHEBI:choline) |
| Jens | a(HBP:HBP00074) | p(HGNC:NGFR) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:HSF1) | p(HGNC:HSF1) | p(HGNC:HSF1) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) | p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) | p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) |
| Jens | a(HBP:"Tau aggregates") | a(MESH:Trehalose) | bp(MESH:Autophagy) |
| Jens | a(CHEBI:"amyloid-beta") | p(FPLX:ERK) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:donepezil) | p(HGNC:CHRNA7) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau oligomers") | a(HBP:"Tau oligomers") | path(MESH:Tauopathies) |
| Jens | a(CHEBI:donepezil) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | p(FPLX:CHRM) |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:"Alzheimer Disease") |
| Jens | bp(MESH:Aging) | p(HGNC:AHSA1) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:HBP00074) | path(MESH:"Alzheimer Disease") | path(MESH:"Cognitive Dysfunction") |
| Jens | a(MESH:Nicotine) | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) |
| Jens | a(HBP:"Corticobasal Degeneration") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT) | p(HGNC:TGM2) |
| Jens | p(HGNC:FKBP5) | p(HGNC:MAPT, pmod(Ph, Ser, 396)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"potassium(1+)") | complex(GO:"NLRP3 inflammasome complex") | p(HGNC:IL1B) |
| Jens | a(CHEBI:"amyloid-beta") | a(HBP:HBP00038) | complex(GO:"NLRP3 inflammasome complex") |
| Jens | a(CHEBI:acetylcholine) | bp(GO:"synaptic transmission, cholinergic") | p(HGNC:ACHE) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:aging) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:HBP00089) | bp(GO:"microglial cell activation") | p(HGNC:CCL2) |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) | p(HGNC:BCHE) |
| Jens | p(MGI:Mapt) | p(MGI:Mapt, var("p.Ala152Thr")) | p(MGI:Mapt, var("p.Ala152Thr")) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | bp(GO:memory) |
| Jens | p(HBP:"cis p-tau") | p(HBP:"cis p-tau") | p(HGNC:PIN1) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | p(HGNC:CHRNA7) |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") | bp(MESH:Autophagy) |
| Jens | a(CHEBI:"amyloid-beta") | complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph, Thr, 231)) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT, var("?")) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CDC37) | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | bp(GO:"neuron death") |
| Jens | a(CHEBI:nicotine) | bp(MESH:Neuroprotection) | p(HGNC:CHRNA7) |
| Jens | p(HGNC:CDC37) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | bp(GO:aging) | p(HGNC:IL1B) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | complex(GO:"inflammasome complex") | p(HGNC:IL18) |
| Jens | a(CHEBI:"proteasome inhibitor") | p(HGNC:BAG3) | p(HGNC:MAPT) |
| Jens | a(CHEBI:Calpeptin) | p(HGNC:CAPN1) | p(HGNC:HTT, var("?")) |
| Jens | a(MESH:Neurons) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") | path(HBP:neurotoxicity) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"MAPK cascade") | p(HGNC:TNF) |
| Jens | complex(GO:axon) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:galanthamine) | p(FPLX:CHRN) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"lithium atom") | bp(GO:autophagy) | p(HGNC:MAPT) |
| Jens | a(PUBCHEM:377503130) | p(FPLX:"CCT_complex") | p(HGNC:HSF1) |
| Jens | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph, Ser, 199)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"okadaic acid") | p(HGNC:MAPT, pmod(Ph, Ser, 202)) | p(HGNC:MAPT, pmod(Sumo, Lys, 340)) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:nicotine) | p(HGNC:CHRNA7) |
| Jens | p(HGNC:MAPT, var("p.Pro301Ser")) | p(HGNC:MAPT, var("p.Pro301Ser")) | p(HGNC:MAPT, var("p.Pro301Ser")) |
| Jens | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") | bp(GO:cognition) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:autophagy) | p(HGNC:CAPN2) | p(HGNC:CAST) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:nicotine) | p(FPLX:CHRN) |
| Jens | a(CHEBI:"potassium(1+)") | complex(GO:"NLRP1 inflammasome complex") | p(HGNC:IL1B) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT) | path(MESH:"Pick Disease of the Brain") |
| Jens | p(HGNC:MAPT) | p(HGNC:NPEPPS) | path(MESH:"Frontotemporal Dementia") |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph, Ser, 404)) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau oligomers") | bp(GO:"mitochondrion organization") | bp(HP:Neurodegeneration) |
| Jens | a(HBP:"Tau epitope, PHF1") | bp(MESH:Autophagy) | p(HGNC:MAPT) |
| Jens | bp(GO:macroautophagy) | p(FPLX:mTORC1) | p(HGNC:SIRT1) |
| Jens | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"cell death") | p(HGNC:CHRM1) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | p(HGNC:ACHE) |
| Jens | a(HBP:"Tau oligomers") | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:GSK3B) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | p(HGNC:PPP1CA) |
| Jens | bp(GO:macroautophagy) | p(FPLX:AMPK) | p(FPLX:mTORC1) |
| Jens | p(HGNC:CTSD) | p(HGNC:MAPT) | path(HBP:neurotoxicity) |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") | p(MGI:Crhr1) |
| Jens | p(HGNC:FKBP5) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | p(MGI:Mapt) | p(MGI:Mapt, var("p.Pro301Leu")) | p(MGI:Mapt, var("p.Pro301Leu")) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:sirolimus) | bp(MESH:Autophagy) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(HBP:"Tau aggregates") | p(HGNCGENEFAMILY:Caspases) | path(MESH:"Neurofibrillary Tangles") |
| Jens | a(CHEBI:galanthamine) | bp(GO:"synaptic transmission, cholinergic") | p(HGNC:ACHE) |
| Jens | p(HGNC:BAG1) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:nicotine) | bp(GO:cognition) | p(HBP:"alpha-4 beta-2 nAChR") |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:acetylcholine) | p(HGNC:CHRNA7) |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau oligomers") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:rivastigmine) | p(HGNC:LRP1) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:oleocanthal) | p(HGNC:ABCB1) |
| Jens | a(CHEBI:sirolimus) | bp(GO:autophagy) | p(FPLX:mTORC1) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"canonical Wnt signaling pathway") | composite(p(HGNC:APP), p(HGNC:VANGL2)) |
| Jens | a(CHEBI:galanthamine) | bp(GO:learning) | p(MGI:App, frag("25_35")) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") | a(MESH:Autophagosomes) |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:dopamine) | a(HBP:HBP00093) |
| Jens | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:acetylcholine) | p(FPLX:CHRN) |
| Jens | bp(GO:autophagy) | p(FPLX:AMPK) | p(FPLX:mTORC1) |
| Jens | a(CHEBI:rivastigmine) | p(HGNC:ABCB1) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:resveratrol) | p(HGNC:MID1) | p(HGNC:PPP2CA) |
| Jens | a(CHEBI:"amyloid-beta") | a(HBP:HBP00018) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CDK5) | p(HGNC:MAPK1) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:PPID) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 40") | a(CHEBI:nicotine) | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | p(HGNC:BAX) |
| Jens | bp(GO:"response to misfolded protein") | p(HGNC:ERN1) | p(HGNC:XBP1) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:TFEB) |
| Jens | a(HBP:HBP00018) | a(HBP:HBP00030) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph, Thr, 181)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:IL1B) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:rivastigmine) | p(HGNC:ACHE) | path(MESH:"Alzheimer Disease") |
| Jens | a(GO:microtubule) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 40") | a(CHEBI:nicotine) | a(HBP:"alpha-4 beta-2 nAChR") |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:AHSA1) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:"long-term synaptic potentiation") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:nicotine) | p(HGNC:CHRNA7) |
| Jens | bp(GO:autophagy) | p(FPLX:mTORC1) | p(HGNC:TFEB) |
| Jens | bp(GO:macroautophagy) | p(FPLX:mTORC1) | p(HGNC:TFEB) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:donepezil) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | a(CHEBI:nicotine) | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:"amyloid-beta") | a(HBP:HBP00038) | bp(GO:phagocytosis) |
| Jens | a(CHEBI:"amyloid-beta") | complex(GO:"NLRP3 inflammasome complex") | p(HGNC:IL1B) |
| Jens | bp(MESH:Aging) | p(FPLX:Proteasome) | path(MESH:"Protein Aggregation, Pathological") |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph, Ser, 214)) | path(MESH:"Alzheimer Disease") |
| Jens | p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) | p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) | p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | a(HBP:"Tau epitope, PHF1") |
| Jens | bp(GO:"depolarization of postsynaptic membrane") | complex(GO:"voltage-gated calcium channel complex") | p(HBP:"alpha-4 beta-2 nAChR") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:ACE) |
| Jens | a(CHEBI:galanthamine) | bp(GO:cognition) | p(HGNC:CHRNA7) |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") | path(HBP:neurotoxicity) |
| Jens | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph, Ser, 422)) | path(MESH:"Alzheimer Disease") |
| Jens | a(GO:presynapse) | a(PUBCHEM:64627) | p(MGI:Adora1) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:MARK4) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:acetylcholine) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CAPN2) | p(HGNC:CAST) | p(HGNC:HTT, var("?")) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | path(MESH:"Diabetes Mellitus") |
| Jens | a(HBP:"Tau oligomers") | p(HGNC:MAPT) | path(MESH:"Pick Disease of the Brain") |
| Jens | a(HBP:"amyloid-beta oligomers") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Jens | a(CHEBI:palbociclib) | a(HBP:"Tau isoform F (441 aa)") | p(HGNC:CDK6) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"canonical Wnt signaling pathway") | p(HGNC:DKK1) |
| Jens | complex(p(HGNC:GSK3B), p(HGNC:MAPT)) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(GO:"neurofibrillary tangle") | p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) | p(MGI:Mapt) |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:acetylcholine) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CAPN2) | path(MESH:"Alzheimer Disease") | path(MESH:"Neurofibrillary Tangles") |
| Jens | a(PUBCHEM:675434) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:donepezil) | p(HGNC:CHRNA4) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:nicotine) | a(HBP:"Tau aggregates") | path(HBP:neurotoxicity) |
| Jens | a(CHEBI:dopamine) | a(CHEBI:nicotine) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"long-term synaptic potentiation") | p(HGNC:FYN) |
| Jens | bp(GO:"anterograde axonal protein transport") | p(HBP:"6D tau", frag("2_18")) | p(MESH:"Glycogen Synthase Kinase 3") |
| Jens | a(CHEBI:nicotine) | bp(GO:memory) | p(HGNC:CHRNA7) |
| Jens | a(MESH:methyllycaconitine) | bp(MESH:Neuroprotection) | p(HGNC:CHRNA7) |
| Jens | p(HGNC:MAPT, pmod(Ph, Ser, 422)) | path(MESH:"Alzheimer Disease") | path(MESH:"Cognitive Dysfunction") |
| Jens | a(CHEBI:simvastatin) | bp(GO:"ERK1 and ERK2 cascade") | bp(GO:"apoptotic process") |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:aging) | p(HGNC:IL1B) |
| Jens | p(HGNC:AK1) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:memory) | p(HGNC:BACE1) |
| Jens | a(CHEBI:"calcium(2+)") | bp(MESH:"Oxidative Stress") | p(HGNC:S100B) |
| Jens | a(CHEBI:Calpeptin) | bp(GO:autophagy) | p(HGNC:CAPN1) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") | bp(MESH:Neuroprotection) |
| Jens | a(GO:"neurofibrillary tangle") | p(HGNC:TGM2) | path(MESH:"Alzheimer Disease") |
| Jens | bp(MESH:Aging) | bp(MESH:Proteolysis) | p(FPLX:HSP90) |
| Jens | p(HGNC:CDK5) | p(HGNC:IL18) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"D-ribose") | a(CHEBI:"advanced glycation end-product") | p(MGI:Mapt, pmod(Ph, Ser, 396)) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA4) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | bp(MESH:Autophagy) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(MESH:"Neurofibrillary Tangles") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | p(MGI:Mapt, var("p.Pro301Leu")) | p(MGI:Mapt, var("p.Pro301Leu")) | p(MGI:Mapt, var("p.Pro301Leu")) |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) | p(HGNC:CHRM1) |
| Jens | a(CHEBI:nicotine) | p(FPLX:PI3K) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | bp(GO:macroautophagy) | p(MGI:Mapt) | p(MGI:Mapt, var("p.Pro301Leu")) |
| Jens | bp(GO:macroautophagy) | p(MGI:Mapt, var("p.Ala152Thr")) | p(MGI:Mapt, var("p.Ala152Thr")) |
| Jens | p(HGNC:CHRNA7) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:nicotine) | a(HBP:"alpha-4 beta-2 nAChR") | a(MESH:"Dopaminergic Neurons") |
| Jens | complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) | p(HGNC:HSPB1) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | p(HGNC:ACHE) |
| Jens | a(HBP:HBP00006) | p(HBP:HBP00053, var("p.Lys280del")) | p(HBP:HBP00053, var("p.Lys280delinsProPro")) |
| Jens | a(HBP:"Tau oligomers") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(GO:"neurofibrillary tangle") | p(ECCODE:"2.3.2.13") | path(MESH:"Supranuclear Palsy, Progressive") |
| Jens | p(FPLX:GSK3) | p(HGNC:MAPT, pmod(Ph, Ser, 199)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:nicotine) | a(MESH:Neurons) | p(MGI:Lynx1) |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:"glutamate(2-)") | bp(HBP:Excitotoxicity) |
| Jens | a(CHEBI:"amyloid-beta") | a(GO:synapse) | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| Jens | a(HBP:HBP00074) | path(MESH:"Alzheimer Disease") | path(MESH:Dementia) |
| Jens | a(CHEBI:"proteasome inhibitor") | bp(GO:autophagy) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") | bp(GO:memory) |
| Jens | a(HBP:"Tau isoform F (441 aa)") | a(HBP:"Tau isoform F (441 aa)") | path(MESH:"Protein Aggregation, Pathological") |
| Jens | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph, Ser, 404)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:nicotine) | bp(GO:cognition) | p(HGNC:CHRNA7) |
| Jens | a(HBP:"Corticobasal Degeneration") | a(HBP:"Tau oligomers") | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:TFEB) | path(MESH:"Plaque, Amyloid") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | bp(GO:phagocytosis) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:water) | path(MESH:"Alzheimer Disease") |
| Jens | a(MESH:"Embryonic Structures") | a(MESH:antalarmin) | bp(MESH:"Heat-Shock Response") |
| Jens | a(CHEBI:dopamine) | a(HBP:HBP00093) | path(MESH:"Parkinson Disease") |
| Jens | a(CHEBI:"D-ribose") | a(HBP:"advanced glycation end product") | p(HGNC:MAPT, pmod(Ph, Thr, 181)) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:aging) | p(HGNC:IL18) |
| Jens | bp(GO:"neuron death") | p(HGNC:BACE1) | path(MESH:"Alzheimer Disease") |
| Jens | p(HBP:HBP00065) | path(MESH:"Alzheimer Disease") | path(MESH:"Plaque, Amyloid") |
| Jens | bp(GO:"neuron death") | p(HGNC:CASP3) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT, pmod(Ac, Lys, 280)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:memory) | p(HGNC:CHRNA7) |
| Jens | a(GO:"neurofibrillary tangle") | p(ECCODE:"2.3.2.13") | path(MESH:"Alzheimer Disease") |
| Jens | p(FPLX:ERK) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"trichostatin A") | p(FPLX:HDAC) | p(HGNC:MAPT, pmod(Ac)) |
| Jens | p(HGNC:FKBP5) | p(HGNC:MAPT, pmod(Ph, Ser, 199)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:galanthamine) | p(MGI:App, frag("25_35")) | path(MESH:"Spatial Memory") |
| Jens | a(HBP:"Tau isoform F (441 aa)") | a(HBP:"Tau isoform F (441 aa)") | a(HBP:"phosphatase-activating domain") |
| Jens | a(CHEBI:"alpha,alpha-trehalose") | bp(GO:autophagy) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:Calpeptin) | p(HGNC:CAPN2) | p(HGNC:HTT, var("?")) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:rosiglitazone) | p(HGNC:PPARG) |
| Jens | a(CHEBI:sirolimus) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:rolipram) | a(HBP:"Tau aggregates") | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | complex(GO:"NLRP1 inflammasome complex") | p(HGNC:IL18) |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:"Lymphatic Vessels") | bp(GO:memory) |
| Jens | a(HBP:"Tau oligomers") | a(HBP:"Tau oligomers") | path(MESH:"Supranuclear Palsy, Progressive") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:IDE) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:HBP00093) | bp(GO:autophagy) | p(HGNC:TFEB) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:APP) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau oligomers") | a(HBP:"Tau oligomers") | bp(HBP:neurotoxicity) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) |
| Jens | a(HBP:"Tau epitope, PHF1") | p(HGNC:GSK3B) | p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| Jens | a(HBP:HBP00006) | p(HBP:HBP00053, var("p.Lys280del")) | p(HGNC:MAPT) |
| Jens | a(HBP:"Tau oligomers") | a(HBP:"Tau oligomers") | path(MESH:"Pick Disease of the Brain") |
| Jens | p(HGNC:FKBP5) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:donepezil) | p(HGNC:BCL2) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | a(HBP:"Tau aggregates") | a(MESH:Autophagosomes) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:MAPT, pmod(Sumo, Lys, 340)) | p(HGNC:MAPT, pmod(Ub)) |
| Jens | bp(GO:macroautophagy) | p(FPLX:mTORC1) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:"calcium(2+)") | complex(p(HGNC:MAPT), p(HGNC:TGM2)) |
| Jens | p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")) | p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")) | p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")) |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") | p(HGNC:CHRM1) |
| Jens | a(HBP:HBP00018) | path(MESH:"Alzheimer Disease") | path(MESH:"Plaque, Amyloid") |
| Jens | a(CHEBI:"D-ribose") | a(HBP:"advanced glycation end product") | p(HGNC:MAPT, pmod(Ph, Ser, 214)) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"canonical Wnt signaling pathway") | p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) |
| Jens | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Jens | a(HBP:"Tau oligomers") | complex(GO:axon) | p(HGNC:MAPT) |
| Jens | a(CHEBI:galanthamine) | bp(GO:"synaptic transmission, cholinergic") | path(MESH:Schizophrenia) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:nicotine) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:nicotine) | p(HBP:"alpha-4 beta-2 nAChR") |
| Jens | bp(GO:aging) | p(HGNC:IL18) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:Microglia) | bp(GO:phagocytosis) |
| Jens | a(CHEBI:"calcium(2+)") | a(MESH:"Receptors, Nicotinic") | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:MMP9) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA3) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | p(HGNC:CHRM1) |
| Jens | p(HBP:"cis p-tau") | p(HBP:"cis p-tau") | p(HBP:"cis p-tau") |
| Jens | bp(GO:"chaperone-mediated autophagy") | p(MGI:Mapt) | p(MGI:Mapt, var("p.Ala152Thr")) |
| Jens | a(CHEBI:Thrombin) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) | p(HGNC:ACHE) |
| Jens | p(HGNC:GSK3B) | p(HGNC:GSK3B, pmod(Ph, Ser, 9)) | p(HGNC:PPP1CA) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | a(CHEBI:nicotine) |
| Jens | a(CHEBI:galanthamine) | p(HGNC:ACHE) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:"calcium(2+)") | a(CHEBI:"calcium(2+)") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | path(MESH:"Plaque, Amyloid") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:resveratrol) | p(FPLX:AMPK) |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:nicotine) | p(HGNC:CHRNA7) |
| Jens | p(HGNC:MAPT) | p(HGNC:TGM2) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:memory) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:rosiglitazone) | bp(GO:"learning or memory") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") | path(MESH:"Alzheimer Disease") |
| Jens | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") | bp(GO:"ERK1 and ERK2 cascade") | bp(GO:"apoptotic process") |
| Jens | a(HBP:HBP00074) | bp(GO:"neuron death") | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:HBP00074) | p(HGNC:NGFR) | path(MESH:"Cognitive Dysfunction") |
| Jens | a(PUBCHEM:675434) | p(HGNC:MAPT) | p(HGNC:USP14) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | p(HGNC:CHRNA4) |
| Jens | a(MESH:"Cholinergic Neurons") | path(MESH:"Alzheimer Disease") | path(MESH:Depression) |
| Jens | bp(GO:"chaperone-mediated autophagy") | p(MGI:Mapt, var("p.Pro301Leu")) | path(MESH:"Proteostasis Deficiencies") |
| Jens | a(CHEBI:donepezil) | p(HGNC:ABCB1) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph, Ser, 396)) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:cognition) | p(HGNC:CHRNA7) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:HBP00089) | bp(GO:"microglial cell activation") | p(HGNC:IL1B) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:CHRM1) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | bp(GO:"MAPK cascade") |
| Jens | a(CHEBI:"amyloid-beta") | complex(GO:"inflammasome complex") | p(HGNC:IL1B) |
| Jens | p(HGNC:MAPT, pmod(Ph, Thr, 205)) | p(HGNC:MAPT, var("p.Pro301Ser")) | p(HGNC:MAPT, var("p.Pro301Ser")) |
| Jens | a(CHEBI:"amyloid-beta") | a(GO:lysosome) | p(HGNC:TFEB) |
| Jens | p(FPLX:ERK) | p(HGNC:MAPT, pmod(Ph, Ser, 404)) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:cognition) | p(HGNC:FYN) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) | bp(GO:"synaptic transmission, cholinergic") |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:"glutamate(2-)") | p(HGNC:CHRNA7) |
| Jens | p(HGNC:MAPT, pmod(Ph)) | p(HGNC:PPP5C) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:"neuron death") | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | p(FPLX:GSK3) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | bp(MESH:Autophagy) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:Astrocytes) | p(HGNC:IL1B) |
| Jens | a(HBP:"sonicated tau fibrils") | a(HBP:"sonicated tau fibrils") | a(HBP:"sonicated tau fibrils") |
| Jens | bp(HBP:"protein aggregation") | complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) | p(MESH:Proteins, pmod(HBP:misfolding)) |
| Jens | a(HBP:"Tau oligomers") | a(HBP:"Tau oligomers") | a(HBP:"Tau oligomers") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | p(HGNC:BCL2) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:ABCB1) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:nilotinib) | bp(GO:macroautophagy) | p(HGNC:ABL1) |
| Jens | a(GO:"late endosome") | p(MGI:Mapt) | p(MGI:Mapt, var("p.Pro301Leu")) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:resveratrol) | bp(GO:"autophagosome assembly") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | bp(GO:"long-term synaptic potentiation") |
| Jens | a(CHEBI:Anatabine) | a(GO:"myelin sheath") | path(MESH:Encephalomyelitis) |
| Jens | a(CHEBI:galanthamine) | bp(GO:learning) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:wogonin) | bp(GO:autophagy) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:AGER) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") | p(FPLX:CHRN) | path(MESH:"Alzheimer Disease") |
| Jens | bp(MESH:Neuroprotection) | p(HGNC:CHRNA7) | p(HGNC:JAK2) |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:"Lymphatic Vessels") | bp(GO:aging) |
| Jens | a(CHEBI:Calpeptin) | bp(GO:autophagy) | p(HGNC:CAPN2) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | complex(GO:"NLRP3 inflammasome complex") |
| Jens | p(HGNC:CDC37) | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph, Ser, 199)) |
| Jens | p(HGNC:BAG1) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(GO:microtubule) | a(HBP:"Tau oligomers") | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | a(MESH:"Cholinesterase Inhibitors") |
| Jens | a(CHEBI:chloroquine) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:nicotine) | bp(GO:"MAPK cascade") | p(HBP:"alpha-4 beta-2 nAChR") |
| Jens | a(CHEBI:scopolamine) | a(MESH:VU0357017) | bp(GO:"behavioral fear response") |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) | complex(a(CHEBI:acetylcholine), p(MESH:D011950)) |
| Jens | bp(MESH:Aging) | p(FPLX:HSP90) | p(FPLX:Proteasome) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:rosiglitazone) | bp(GO:memory) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"innate immune response") | complex(GO:"NLRP3 inflammasome complex") |
| Jens | a(HBP:"Tau epitope, PHF1") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| Jens | a(HBP:"Tau aggregates") | bp(MESH:Autophagy) | p(HGNC:MAPT) |
| Jens | bp(GO:"long-term synaptic potentiation") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| Jens | a(CHEBI:"D-ribose") | a(CHEBI:"advanced glycation end-product") | p(MGI:Mapt, pmod(Ph, Ser, 214)) |
| Jens | a(CHEBI:nicotine) | bp(GO:"ERK1 and ERK2 cascade") | bp(GO:"apoptotic process") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:MMP3) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:donepezil) | p(HGNC:LRP1) |
| Jens | a(HP:"glymphatic system") | p(HGNC:MAPT) | path(MESH:"Brain Injuries, Traumatic") |
| Jens | a(CHEBI:dopamine) | a(CHEBI:nicotine) | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:"calcium(2+)") | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:memory) | g(HGNC:NLRP3) |
| Jens | path(MESH:"Alzheimer Disease") | path(MESH:"Cognitive Dysfunction") | path(MESH:"Plaque, Amyloid") |
| Jens | a(CHEBI:"methylene blue") | a(HBP:"Tau aggregates") | bp(MESH:Autophagy) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | p(FPLX:PI3K) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"cerebrospinal fluid circulation") | bp(GO:aging) |
| Jens | a(GO:"neurofibrillary tangle") | p(HGNC:CDKN2A) | path(MESH:"Supranuclear Palsy, Progressive") |
| Jens | a(CHEBI:rivastigmine) | p(HGNC:LRP1) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:MMP2) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"potassium(1+)") | complex(GO:"inflammasome complex") | p(HGNC:IL1B) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:simvastatin) | bp(GO:"apoptotic process") |
| Jens | p(FPLX:GSK3) | p(HGNC:MAPT, pmod(Ph, Ser, 396)) | path(MESH:"Alzheimer Disease") |
| Jens | p(FPLX:GSK3) | p(HGNC:MAPT, pmod(Ph, Ser, 404)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:APOE) |
| Jens | a(CHEBI:"alpha,alpha-trehalose") | p(HGNC:BAG3) | p(HGNC:MAPT) |
| Jens | bp(HBP:"protein aggregation") | complex(p(HGNC:BAG6), p(HGNC:UBA3)) | p(MESH:Proteins, pmod(HBP:misfolding)) |
| Jens | p(HGNC:CDC37) | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| Jens | p(FPLX:ERK) | p(HGNC:MAPT, pmod(Ph, Ser, 199)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:dextran) | a(CHEBI:dextran) | a(CHEBI:dextran) |
| Jens | p(HGNC:MAPT, pmod(Ph, Ser, 202)) | p(HGNC:MAPT, var("p.Pro301Ser")) | p(HGNC:MAPT, var("p.Pro301Ser")) |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau oligomers") | bp(MESH:Autophagy) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:"Alzheimer Disease") |
| Jens | bp(MESH:Autophagy) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") | a(MESH:Microglia) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:simvastatin) | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| Jens | a(CHEBI:sirolimus) | bp(MESH:Autophagy) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CAPN1) | p(HGNC:CAST) | p(HGNC:HTT, var("?")) |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) | p(HGNC:CHAT) |
| Jens | a(CHEBI:"amyloid-beta") | p(FPLX:JNK) | p(HGNC:AGER) |
| Jens | a(CHEBI:cilostazol) | bp(GO:macroautophagy) | p(HGNC:MAPT, pmod(HBP:HBP00007)) |
| Jens | a(CHEBI:"amyloid-beta") | p(FPLX:JNK) | p(HGNC:DKK1) |
| Jens | a(HBP:"Tau aggregates") | bp(GO:"lysosomal microautophagy") | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:IL18) | path(MESH:"Alzheimer Disease") | path(MESH:Dementia) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | bp(GO:"apoptotic process") |
| Jens | a(MESH:"Cholinergic Neurons") | path(MESH:"Alzheimer Disease") | path(MESH:Apathy) |
| Jens | bp(GO:"protein folding") | bp(MESH:Aging) | p(FPLX:HSP90) |
| Jens | p(HGNC:AK1) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:DAPK1) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:donepezil) | p(HGNC:ACHE) |
| Jens | p(MGI:Rela, pmod(Ph)) | p(MGI:Stat3, pmod(Ph)) | path(MESH:Encephalomyelitis) |
| Jens | a(HBP:"Tau epitope, PHF1") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) |
| Jens | bp(GO:"microtubule polymerization") | p(HGNC:DAPK1) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") | bp(GO:memory) |
| Jens | a(HBP:HBP00074) | bp(GO:aging) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:aging) | p(HGNC:FKBP5) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:phagocytosis) | complex(GO:"NLRP3 inflammasome complex") |
| Jens | a(HBP:"Tau oligomers") | a(HBP:"Tau oligomers") | path(MESH:"Alzheimer Disease") |
| Jens | a(MESH:D002800) | bp(GO:"GO:0014047") | path(MESH:D000544) |
| Jens | p(HGNC:MAPT, pmod(Ph)) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:HBP00018) | p(HGNC:IDE) | path(MESH:"Alzheimer Disease") |
| Jens | a(MESH:Lysosomes) | bp(MESH:Proteolysis) | path(MESH:"Alzheimer Disease") |
| Jens | a(MESH:"Neurofibrillary Tangles") | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CDC37) | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph, Ser, 202)) |
| Jens | a(MESH:antalarmin) | path(HBP:"isolation rearing") | r(RGD:Ntrk2) |
| Jens | a(CHEBI:sirolimus) | bp(GO:autophagy) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") | bp(GO:"apoptotic process") |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:dopamine) | a(CHEBI:nicotine) |
| Jens | a(CHEBI:"glutamate(2-)") | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) |
| Jens | p(HGNC:FYN) | p(HGNC:MAPT, pmod(Ph, Tyr, 18)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"Hsp90 inhibitor") | a(CHEBI:"N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal") | p(HGNC:MAPT) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT) | path(MESH:"Frontotemporal Dementia") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | path(HBP:neurotoxicity) |
| Jens | a(HBP:"Tau oligomers") | bp(MESH:Autophagy) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | a(MESH:Kidney) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:BACE1) | p(HGNC:CHRM1) |
| Jens | bp(GO:"clathrin-dependent endocytosis") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:MAPT, pmod(Ph)) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(MGI:Bace1) |
| Jens | a(CHEBI:acetylcholine) | a(CHEBI:nicotine) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | a(CHEBI:acetylcholine) | bp(GO:"membrane depolarization") | p(FPLX:CHRN) |
| Jens | p(HGNC:ABL1) | p(HGNC:MAPT, pmod(Ph, Tyr, 394)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"lithium(1+)") | bp(GO:autophagy) | p(HGNC:MAPT) |
| Jens | a(CHEBI:sirolimus) | bp(GO:macroautophagy) | p(FPLX:mTORC1) |
| Jens | a(CHEBI:"lithium(1+)") | bp(GO:autophagy) | p(HGNC:SNCA) |
| Jens | p(HBP:"CDK5R1 p25") | p(HBP:"Tau epitope, AT8") | p(MGI:Cdk5) |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") |
| Jens | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") | p(MGI:App, frag("25_35")) | path(MESH:"Spatial Memory") |
| Jens | a(CHEBI:"calcium(2+)") | a(CHEBI:nicotine) | p(HBP:"alpha-4 beta-2 nAChR") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | bp(GO:memory) |
| Jens | bp(GO:autophagy) | p(HGNC:HSPB1) | p(HGNC:MAPT) |
| Jens | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) | complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) |
| Jens | a(HBP:"Tau aggregates") | a(HBP:"Tau aggregates") | p(HGNC:HSPA1A) |
| Jens | a(CHEBI:"amyloid-beta") | complex(GO:"NLRP1 inflammasome complex") | p(HGNC:IL1B) |
| Jens | a(CHEBI:nicotine) | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") | bp(GO:"ERK1 and ERK2 cascade") |
| Jens | complex(GO:"inflammasome complex") | p(HGNC:CASP1) | p(HGNC:IL18) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ac, Lys, 174)) | p(HGNC:MAPT, pmod(Ph, Thr, 205)) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:BACE1) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau oligomers") | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | bp(MESH:Autophagy) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(HP:"interstitial fluid") | bp(GO:aging) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:nicotine) | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| Jens | a(CHEBI:scopolamine) | a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") | bp(GO:"behavioral fear response") |
| Jens | a(HBP:"Tau aggregates") | complex(GO:"proteasome complex") | p(HGNC:MAPT, var("?")) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:WNT3A) |
| Jens | complex(a(GO:"proteasome complex"), p(HGNC:PRKN)) | p(HGNC:PRKN, var("p.Arg42")) | path(MESH:"Parkinsonian Disorders") |
| Jens | a(CHEBI:acrolein) | path(MESH:"Alzheimer Disease") | path(MESH:"Plaque, Amyloid") |
| Jens | bp(MESH:Aging) | p(FPLX:HSP90) | p(HGNC:PTGES3) |
| Jens | a(CHEBI:"amyloid-beta") | a(HBP:HBP00018) | p(HGNC:TFEB) |
| Jens | a(HBP:"Tau aggregates") | path(MESH:"Alzheimer Disease") | path(MESH:"Neurofibrillary Tangles") |
| Jens | a(PUBCHEM:675434) | p(FPLX:Proteasome) | p(HGNC:USP14) |
| Jens | p(HBP:HBP00053, var("p.Lys280del")) | p(HBP:HBP00053, var("p.Lys280del")) | p(HBP:HBP00053, var("p.Lys280del")) |
| Jens | bp(GO:"chaperone-mediated autophagy") | p(MGI:Mapt) | p(MGI:Mapt, var("p.Pro301Leu")) |
| Jens | a(CHEBI:"methylene blue") | bp(MESH:Autophagy) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:palbociclib) | a(HBP:"Tau isoform F (441 aa)") | p(HGNC:CDK4) |
| Jens | p(HGNC:CHAT) | path(MESH:"Alzheimer Disease") | path(MESH:Dementia) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA4) |
| Jens | a(CHEBI:curcumin) | bp(GO:macroautophagy) | p(FPLX:mTORC1) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:AQP4) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | p(FPLX:CHRN) |
| Jens | a(CHEBI:"Hsp90 inhibitor") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") | bp(GO:learning) | p(MGI:App, frag("25_35")) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"MAPK cascade") | p(HGNC:CHRNA7) |
| Jens | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") | path(MESH:Inflammation) |
| Jens | a(MESH:Astrocytes) | p(HGNC:APP) | p(HGNC:IL1B) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | p(HGNC:TNF) |
| Jens | a(MESH:Lysosomes) | p(HGNC:MAPT) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:autophagy) | bp(MESH:Aging) | p(FPLX:HSP90) |
| Jens | a(HBP:"Tau oligomers") | a(HBP:"Tau oligomers") | p(HGNC:MAPT) |
| Jens | a(MESH:"Neurofibrillary Tangles") | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | p(FPLX:CHRN) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HBP:"Tau aggregates") |
| Jens | a(HBP:"Tau oligomers") | a(HBP:"Tau oligomers") | p(HBP:"phosphatase-activating domain") |
| Jens | a(HBP:"Tau oligomers") | a(HBP:"Tau oligomers") | a(HBP:neuroinflammation) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:CASP1) | p(HGNC:IL1B) |
| Jens | a(CHEBI:"D-ribose") | a(HBP:"advanced glycation end product") | p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| Jens | p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) | p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) | p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) |
| Jens | a(MESH:Neurons) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:donepezil) | p(HGNC:CHRNA7) |
| Jens | bp(GO:"microtubule polymerization") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | a(CHEBI:acetylcholine) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:CASP1) | p(HGNC:IL18) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | a(CHEBI:rosiglitazone) |
| Jens | a(CHEBI:"methylene blue") | bp(GO:autophagy) | p(HGNC:MAPT) |
| Jens | a(CHEBI:acetylcholine) | bp(GO:"action potential initiation") | p(HGNC:CHRNA7) |
| Jens | bp(MESH:Aging) | p(HGNC:PTGES3) | path(MESH:"Protein Aggregation, Pathological") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:rosiglitazone) | a(HBP:HBP00018) |
| Jens | a(HBP:"Tau oligomers") | p(HGNC:AHSA1) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"amyloid-beta aggregates") | path(MESH:"Alzheimer Disease") | path(MESH:"Plaque, Amyloid") |
| Jens | a(GO:"neurofibrillary tangle") | a(HBP:"Tau aggregates") | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:"cell death") | p(HGNC:RNF19A) | p(HGNC:SOD1, var("?")) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA7) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:Microglia) | p(HGNC:TREM2, var("p.Arg47His")) |
| Jens | a(CHEBI:"amyloid-beta") | bp(MESH:"Neuronal Outgrowth") | p(MGI:Chrna7) |
| Jens | a(CHEBI:acrolein) | a(GO:"neurofibrillary tangle") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"long-term synaptic potentiation") | p(MGI:Chrm1) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:donepezil) | p(HGNC:ABCB1) |
| Jens | a(MESH:Neurons) | a(PUBCHEM:64627) | p(MGI:Adora1) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") |
| Jens | a(CHEBI:donepezil) | bp(GO:cognition) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:epoxomicin) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:pioglitazone) | p(HGNC:PPARG) |
| Jens | a(CHEBI:nicotine) | p(HGNC:CHRNA7) | p(HGNC:JAK2) |
| Jens | p(HGNC:APP, frag("672_713")) | p(HGNC:BACE1) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"granulovacuolar degeneration") | p(HGNC:MAPT, pmod(Ph, Ser, 262)) | p(HGNC:MARK4, pmod(Ph)) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | bp(MESH:Neuroprotection) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | a(MESH:Liver) |
| Jens | bp(GO:cognition) | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"neuron death") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:tanespimycin) | bp(GO:memory) |
| Jens | p(HGNC:IL1B) | p(HGNC:PYCARD) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | p(HGNC:CHRM2) |
| Jens | p(HGNC:NGFR) | path(MESH:"Alzheimer Disease") | path(MESH:"Cognitive Dysfunction") |
| Jens | bp(GO:"chaperone-mediated autophagy") | p(MGI:Mapt, var("p.Ala152Thr")) | p(MGI:Mapt, var("p.Ala152Thr")) |
| Jens | bp(GO:macroautophagy) | p(MGI:Mapt) | p(MGI:Mapt, var("p.Ala152Thr")) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:PICALM) |
| Jens | a(CHEBI:acetylcholine) | a(MESH:"Cholinergic Neurons") | bp(GO:memory) |
| Jens | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:nicotine) | path(HBP:neurotoxicity) |
| Jens | p(HGNC:MAPT, pmod(Ac, Lys, 280)) | p(HGNC:MAPT, pmod(Ph, Ser, 262)) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:"microtubule polymerization") | complex(GO:microtubule) | p(HGNC:MAPT) |
| Jens | a(CHEBI:galanthamine) | bp(GO:cognition) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:CDC37) | p(HGNC:CDK5) | p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | a(MESH:D002800) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:ACE) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | path(MESH:"Alzheimer Disease") | path(MESH:"Plaque, Amyloid") |
| Jens | a(GO:"neurofibrillary tangle") | p(HGNC:IL1B) | path(MESH:"Alzheimer Disease") |
| Jens | a(HBP:"Tau aggregates") | complex(GO:"proteasome complex") | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:CHRM1) |
| Jens | a(HBP:"amyloid-beta oligomers") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:galanthamine) | bp(GO:"synaptic transmission, cholinergic") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(MGI:Syk) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:pioglitazone) | bp(GO:memory) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:NGFR) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:IL1B) | path(MESH:"Alzheimer Disease") | path(MESH:Dementia) |
| Jens | a(CHEBI:"amyloid-beta") | p(HGNC:DKK1) | p(HGNC:WNT3A) |
| Jens | a(CHEBI:"amyloid-beta") | p(FPLX:TLR) | p(HGNC:IL1B) |
| Jens | bp(GO:autophagy) | p(HGNC:CAPN1) | p(HGNC:CAST) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(MGI:Chrna7) |
| Jens | a(GO:"neurofibrillary tangle") | p(HBP:"CDK5R1 p25") | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:nicotine) | a(MESH:"SNARE Proteins") | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:oleocanthal) | p(HGNC:LRP1) |
| Jens | a(CHEBI:lactacystin) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(HBP:"Tau aggregates") | p(HGNC:MAPT, pmod(Ph, Thr, 231)) | path(MESH:"Alzheimer Disease") |
| Jens | bp(GO:"long-term synaptic potentiation") | p(HGNC:HSPB1) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:MMP2) |
| Jens | p(HGNC:PRNP) | p(HGNC:PRNP) | p(HGNC:PRNP) |
| Jens | a(CHEBI:"amyloid-beta") | a(HBP:HBP00018) | p(HGNC:IDE) |
| Jens | complex(p(HGNC:FYN), p(HGNC:MAPT)) | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | a(MESH:"Neurofibrillary Tangles") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Jens | bp(MESH:Aging) | p(FPLX:HSP90) | path(MESH:"Protein Aggregation, Pathological") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"apoptotic process") | p(HGNC:CHRNA7) |
| Jens | a(GO:mitochondrion) | bp(MESH:"Oxidative Stress") | p(HGNC:GLP1R) |
| Jens | a(MESH:Hippocampus) | p(HGNC:CHRNA7) | path(MESH:Schizophrenia) |
| Jens | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") | bp(GO:"synaptic transmission, cholinergic") | p(HGNC:ACHE) |
| Jens | a(CHEBI:cilostazol) | bp(GO:macroautophagy) | p(FPLX:mTORC1) |
| Jens | a(CHEBI:acetylcholine) | bp(GO:"membrane depolarization") | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) |
| Jens | a(HBP:"Tau aggregates") | p(HBP:"Tau epitope, AT8") | p(MGI:Crhr1) |
| Jens | bp(GO:autophagy) | p(HGNC:HSPB1) | p(HGNC:MAPT, pmod(Ph)) |
| Jens | a(HBP:"Tau isoform F (441 aa)") | a(HBP:"Tau isoform F (441 aa)") | a(HBP:"Tau isoform F (441 aa)") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:donepezil) | p(HGNC:CHRNA4) |
| Jens | a(CHEBI:epoxomicin) | p(HGNC:CASP3) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | path(MESH:"Alzheimer Disease") | path(MESH:"Diabetes Mellitus") |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"long-term synaptic potentiation") | p(HGNC:CHRM1) |
| Jens | a(CHEBI:donepezil) | p(HGNC:ACHE) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:"potassium(1+)") | p(HGNC:IL1B) | p(HGNC:PYCARD) |
| Jens | bp(GO:"neuron death") | p(HGNC:MMP2) | path(MESH:"Alzheimer Disease") |
| Jens | p(FPLX:CALM) | p(HBP:"DAPK, basic loop (BL) motif") | p(HGNC:DAPK2) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:nicotine) | bp(MESH:Neuroprotection) |
| Jens | a(CHEBI:"amyloid-beta") | a(MESH:Synapses) | p(FPLX:PI3K) |
| Jens | a(CHEBI:"amyloid-beta") | bp(GO:"inflammatory response") | p(HGNC:DKK1) |
| Jens | a(CHEBI:nicotine) | bp(GO:"MAPK cascade") | p(FPLX:NFkappaB) |
| Jens | complex(GO:"inflammasome complex") | p(HGNC:CASP1) | p(HGNC:IL1B) |
| Jens | complex(GO:"filamentous actin") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta polypeptide 42") | a(CHEBI:nicotine) | a(HBP:"alpha-4 beta-2 nAChR") |
| Jens | a(MESH:Trehalose) | bp(MESH:Autophagy) | p(HGNC:MAPT) |
| Jens | a(GO:"neurofibrillary tangle") | p(HGNC:MAPT, pmod(Ph)) | path(MESH:"Alzheimer Disease") |
| Jens | a(CHEBI:acetylcholine) | bp(GO:"synaptic transmission, cholinergic") | bp(GO:memory) |
| Jens | a(CHEBI:galanthamine) | bp(MESH:Neuroprotection) | p(HGNC:CHRNA7) |
| Jens | a(CHEBI:rolipram) | complex(GO:"proteasome complex") | p(FPLX:PKA) |
| Jens | a(CHEBI:sirolimus) | bp(GO:autophagy) | p(HGNC:SNCA) |
| Jens | a(CHEBI:"calcium(2+)") | p(HGNC:CHRNA7) | p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:rivastigmine) | p(HGNC:ABCB1) |
| Jens | a(CHEBI:"amyloid-beta") | complex(GO:"NLRP3 inflammasome complex") | p(HGNC:IL18) |
| Jens | p(HGNC:MAPT) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ub)) |
| Jens | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") | bp(GO:"synaptic transmission, cholinergic") | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:ITPKB) | path(MESH:"Alzheimer Disease") | path(MESH:"Plaque, Amyloid") |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) |
| Jens | p(FPLX:ERK) | p(HGNC:MAPT, pmod(Ph, Ser, 396)) | path(MESH:"Alzheimer Disease") |
| Jens | p(HGNC:HDAC6) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Jens | a(CHEBI:"amyloid-beta") | a(CHEBI:rivastigmine) | p(HGNC:ACHE) |
| Increase Mismatch | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA7) | path(MESH:"Alzheimer Disease") |
| Increase Mismatch | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA3) | path(MESH:"Alzheimer Disease") |
| Increase Mismatch | a(CHEBI:"amyloid-beta") | path(MESH:"Alzheimer Disease") | p(HGNC:CHRNA4) |
| Increase Mismatch | path(MESH:"Alzheimer Disease") | p(HGNC:MAPT, pmod(Ph, Thr, 231)) | p(HGNC:MAPT) |
| Increase Mismatch | a(CHEBI:nicotine) | a(CHEBI:acetylcholine) | bp(GO:cognition) |
| Increase Mismatch | a(MESH:"Cholinesterase Inhibitors") | bp(GO:cognition) | a(CHEBI:acetylcholine) |
| Increase Mismatch | p(HBP:"APOE e4") | p(MGI:Cdk5) | p(MGI:Cdk5r1) |
| Increase Mismatch | p(HGNC:CHRM1) | a(CHEBI:acetylcholine) | bp(GO:cognition) |
| Increase Mismatch | a(CHEBI:"nicotinic acetylcholine receptor agonist") | bp(GO:cognition) | a(CHEBI:acetylcholine) |
| Increase Mismatch | a(PUBCHEM:9867750) | bp(GO:cognition) | a(CHEBI:acetylcholine) |
| Increase Mismatch | a(HBP:HBP00030) | path(MESH:"Alzheimer Disease") | a(CHEBI:"amyloid-beta polypeptide 42") |
| Increase Mismatch | p(HGNC:STUB1) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ub)) |
| Increase Mismatch | p(HGNCGENEFAMILY:Proteasome) | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(Ub)) |
| Increase Mismatch | complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) | p(HGNC:MAPT, pmod(Ph)) | rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) |
| Increase Mismatch | a(CHEBI:rolipram) | p(HGNC:MAPT) | complex(GO:"proteasome complex") |
| Increase Mismatch | p(HGNC:DAPK1) | bp(GO:"apoptotic process") | p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| Increase Mismatch | p(HGNC:DAPK1) | bp(GO:"apoptotic process") | p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| Increase Mismatch | p(HGNC:DAPK1) | bp(GO:"apoptotic process") | p(HGNC:MAPT, pmod(Ph, Ser, 262)) |
| Decrease Mismatch | path(MESH:"Alzheimer Disease") | a(CHEBI:acetylcholine) | bp(GO:cognition) |
| Decrease Mismatch | path(MESH:"Alzheimer Disease") | a(MESH:Neurons) | p(FPLX:CHRN) |
| Decrease Mismatch | path(MESH:"Alzheimer Disease") | a(MESH:Brain) | p(FPLX:CHRN) |
| Decrease Mismatch | a(CHEBI:galanthamine) | path(MESH:"Alzheimer Disease") | p(HGNC:ACHE) |
| Decrease Mismatch | a(CHEBI:donepezil) | p(HGNC:ACHE) | path(MESH:"Alzheimer Disease") |
| Decrease Mismatch | a(CHEBI:rivastigmine) | p(HGNC:ACHE) | path(MESH:"Alzheimer Disease") |
| Decrease Mismatch | a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") | p(HGNC:ACHE) | path(MESH:"Alzheimer Disease") |
| Decrease Mismatch | a(CHEBI:lactacystin) | p(HGNC:MAPT) | complex(GO:"proteasome complex") |
| Decrease Mismatch | p(HGNC:USP14) | p(HGNC:MAPT) | complex(GO:"proteasome complex") |
| Decrease Mismatch | a(CHEBI:tanespimycin) | p(HGNC:MAPT) | p(SFAM:"HSP90 Family") |
Like unstable pairs, unstable triplets require additional context to understand their mechanisms of regulation.
A
increases B, B increases C, and C increases A.
A
decreases B, B decreases C, and C decreases A.
| Type | Node A | Node B | Node C |
|---|---|---|---|
| Chaotic | a(CHEBI:"calcium(2+)") | a(CHEBI:acetylcholine) | p(HGNC:CHRNA7) |
| Chaotic | a(CHEBI:"calcium(2+)") | a(MESH:"Receptors, Nicotinic") | p(HGNC:CHRNA7) |
| Chaotic | a(CHEBI:nicotine) | p(FPLX:PI3K) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Chaotic | a(CHEBI:"calcium(2+)") | a(CHEBI:acetylcholine) | a(CHEBI:choline) |
| Chaotic | a(HBP:"Tau oligomers") | p(HGNC:MAPT) | path(MESH:"Brain Injuries, Traumatic") |
| Chaotic | a(CHEBI:"calcium(2+)") | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) |
| Chaotic | a(CHEBI:"amyloid-beta polypeptide 42") | bp(GO:phagocytosis) | p(HGNC:TREM2) |
| Chaotic | a(CHEBI:"amyloid-beta") | complex(GO:"NLRP1 inflammasome complex") | p(HGNC:IL1B) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) |
| Chaotic | a(CHEBI:"calcium(2+)") | a(CHEBI:dopamine) | a(HBP:HBP00093) |
| Chaotic | a(CHEBI:nicotine) | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") | bp(GO:"ERK1 and ERK2 cascade") |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:BACE1) | path(MESH:"Alzheimer Disease") |
| Chaotic | a(CHEBI:"amyloid-beta") | complex(GO:"inflammasome complex") | p(HGNC:IL18) |
| Chaotic | a(CHEBI:"calcium(2+)") | a(CHEBI:acetylcholine) | p(FPLX:CHRN) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA7) | path(MESH:"Alzheimer Disease") |
| Chaotic | a(CHEBI:"amyloid-beta") | bp(GO:"inflammatory response") | p(HGNC:DKK1) |
| Chaotic | a(CHEBI:"calcium(2+)") | a(CHEBI:"calcium(2+)") | p(HGNC:CHRNA7) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(FPLX:TLR) | p(HGNC:IL1B) |
| Chaotic | a(CHEBI:"amyloid-beta") | bp(GO:"MAPK cascade") | p(HGNC:TNF) |
| Chaotic | a(CHEBI:"amyloid-beta") | bp(GO:phagocytosis) | complex(GO:"NLRP3 inflammasome complex") |
| Chaotic | a(CHEBI:"amyloid-beta") | complex(GO:"NLRP1 inflammasome complex") | p(HGNC:IL18) |
| Chaotic | bp(GO:"response to misfolded protein") | p(HGNC:ERN1) | p(HGNC:XBP1) |
| Chaotic | a(HBP:"Tau oligomers") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Chaotic | a(CHEBI:"calcium(2+)") | a(CHEBI:acetylcholine) | a(MESH:"Receptors, Nicotinic") |
| Chaotic | a(CHEBI:nicotine) | a(MESH:"SNARE Proteins") | p(HGNC:CHRNA7) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:MMP2) | path(MESH:"Alzheimer Disease") |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:APP) | path(MESH:"Alzheimer Disease") |
| Chaotic | complex(GO:"filamentous actin") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Chaotic | a(CHEBI:"calcium(2+)") | a(CHEBI:"glutamate(2-)") | bp(HBP:Excitotoxicity) |
| Chaotic | a(CHEBI:nicotine) | a(MESH:Neurons) | p(MGI:Lynx1) |
| Chaotic | a(CHEBI:"calcium(2+)") | a(CHEBI:acetylcholine) | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:AGER) | path(MESH:"Alzheimer Disease") |
| Chaotic | a(CHEBI:nicotine) | p(HGNC:CHRNA7) | p(HGNC:JAK2) |
| Chaotic | p(HGNC:APP, frag("672_713")) | p(HGNC:BACE1) | path(MESH:"Alzheimer Disease") |
| Chaotic | a(CHEBI:"calcium(2+)") | a(CHEBI:nicotine) | p(HGNC:CHRNA7) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:CASP1) | p(HGNC:IL1B) |
| Chaotic | a(CHEBI:"calcium(2+)") | p(HGNC:MAPT) | p(HGNCGENEFAMILY:Calpains) |
| Chaotic | a(CHEBI:"amyloid-beta") | a(HBP:HBP00038) | complex(GO:"NLRP3 inflammasome complex") |
| Chaotic | a(MESH:Neurons) | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Chaotic | a(CHEBI:acetylcholine) | bp(GO:"membrane depolarization") | p(FPLX:CHRN) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(HGNC:CASP1) | p(HGNC:IL18) |
| Chaotic | a(CHEBI:"amyloid-beta") | complex(GO:"NLRP3 inflammasome complex") | p(HGNC:IL18) |
| Chaotic | a(CHEBI:"amyloid-beta") | a(CHEBI:simvastatin) | a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") |
| Chaotic | a(CHEBI:acetylcholine) | a(CHEBI:nicotine) | p(HGNC:CHRNA7) |
| Chaotic | a(MESH:"Neurofibrillary Tangles") | p(HGNC:MAPT) | p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) |
| Chaotic | a(CHEBI:acetylcholine) | bp(GO:"action potential initiation") | p(HGNC:CHRNA7) |
| Chaotic | a(CHEBI:"amyloid-beta") | bp(GO:"innate immune response") | complex(GO:"NLRP3 inflammasome complex") |
| Chaotic | a(CHEBI:nicotine) | p(HGNC:CHRNA7) | p(HGNC:CHRNA7) |
| Chaotic | a(CHEBI:"amyloid-beta") | bp(GO:"MAPK cascade") | p(HGNC:CHRNA7) |
| Chaotic | a(CHEBI:"amyloid-beta") | a(HBP:HBP00038) | bp(GO:phagocytosis) |
| Chaotic | a(CHEBI:"amyloid-beta") | p(FPLX:JNK) | p(HGNC:DKK1) |
| Chaotic | a(CHEBI:"amyloid-beta") | complex(GO:"inflammasome complex") | p(HGNC:IL1B) |
| Chaotic | a(CHEBI:"amyloid-beta") | complex(GO:"NLRP3 inflammasome complex") | p(HGNC:IL1B) |
| Chaotic | a(CHEBI:acetylcholine) | bp(GO:"membrane depolarization") | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| Chaotic | a(MESH:"Neurofibrillary Tangles") | p(HGNC:MAPT) | p(HGNC:MAPT) |
| Chaotic | a(CHEBI:"amyloid-beta") | a(CHEBI:acetylcholine) | p(HGNC:CHRNA7) |
| Dampened | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:CHRM1) |
| Dampened | p(HBP:"cis p-tau") | p(HBP:"cis p-tau") | p(HGNC:PIN1) |
| Dampened | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | p(HGNC:CHRNA7) |
| Dampened | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | a(CHEBI:nicotine) |
| Dampened | a(CHEBI:"amyloid-beta") | a(CHEBI:"amyloid-beta") | complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) |
Pathologies are more dogmatically the result of molecular and physical processes, and do not necessarily make sense as the subject of causal statements.
| Source | Relation | Target |
|---|---|---|
| path(HBP:"high-fat prenatal maternal diet") | increases | a(CHEBI:"amyloid-beta") |
| path(HBP:"isolation rearing") | increases | p(RGD:Drd2) |
| path(HBP:"isolation rearing") | increases | p(RGD:Drd3) |
| path(HBP:"isolation rearing") | decreases | r(RGD:Bdnf) |
| path(HBP:"isolation rearing") | increases | r(RGD:Bdnf) |
| path(HBP:"isolation rearing") | decreases | r(RGD:Ntrk2) |
| path(HBP:"isolation rearing") | increases | r(RGD:Ntrk2) |
| path(MESH:"Alzheimer Disease") | decreases | a(CHEBI:"amyloid-beta") |
| path(MESH:"Alzheimer Disease") | increases | a(CHEBI:"amyloid-beta") |
| path(MESH:"Alzheimer Disease") | increases | a(CHEBI:Thrombin) |
| path(MESH:"Alzheimer Disease") | decreases | a(CHEBI:acetylcholine) |
| path(MESH:"Alzheimer Disease") | decreases | a(CHEBI:water) |
| path(MESH:"Alzheimer Disease") | increases | a(GO:autolysosome) |
| path(MESH:"Alzheimer Disease") | increases | a(HBP:"Tau oligomers") |
| path(MESH:"Alzheimer Disease") | decreases | a(HBP:"alpha-4 beta-2 nAChR") |
| path(MESH:"Alzheimer Disease") | increases | a(HBP:HBP00018) |
| path(MESH:"Alzheimer Disease") | increases | a(MESH:"Basal Nucleus of Meynert") |
| path(MESH:"Alzheimer Disease") | decreases | a(MESH:"Cholinergic Neurons") |
| path(MESH:"Alzheimer Disease") | decreases | a(MESH:"Cholinesterase Inhibitors") |
| path(MESH:"Alzheimer Disease") | increases | a(MESH:"Neurofibrillary Tangles") |
| path(MESH:"Alzheimer Disease") | increases | a(MESH:Autophagosomes) |
| path(MESH:"Alzheimer Disease") | decreases | a(MESH:Brain) |
| path(MESH:"Alzheimer Disease") | decreases | a(MESH:Neurons) |
| path(MESH:"Alzheimer Disease") | decreases | complex(a(CHEBI:acetylcholine), p(FPLX:CHRM)) |
| path(MESH:"Alzheimer Disease") | decreases | complex(a(CHEBI:acetylcholine), p(FPLX:CHRN)) |
| path(MESH:"Alzheimer Disease") | decreases | complex(a(CHEBI:nicotine), p(FPLX:CHRM)) |
| path(MESH:"Alzheimer Disease") | decreases | complex(a(CHEBI:nicotine), p(FPLX:CHRN)) |
| path(MESH:"Alzheimer Disease") | decreases | complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) |
| path(MESH:"Alzheimer Disease") | increases | complex(p(HGNC:ESR1), p(HGNC:MAPT)) |
| path(MESH:"Alzheimer Disease") | increases | complex(p(HGNC:FYN), p(HGNC:MAPT)) |
| path(MESH:"Alzheimer Disease") | increases | complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Proteasome)) |
| path(MESH:"Alzheimer Disease") | decreases | p(ECCODE:"2.7.11.31", pmod(Ph, Thr, 172)) |
| path(MESH:"Alzheimer Disease") | increases | p(ECCODE:"3.1.1.89") |
| path(MESH:"Alzheimer Disease") | decreases | p(FPLX:CHRM) |
| path(MESH:"Alzheimer Disease") | decreases | p(FPLX:CHRN) |
| path(MESH:"Alzheimer Disease") | decreases | p(HBP:"alpha-4 beta-2 nAChR") |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:ABCB1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:ABL1) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:ACHE) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:AGER) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:AK1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:APP) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:BACE1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:BCHE) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:CAPN2) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:CHAT) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:CHRNA3) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:CHRNA4) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:CHRNA7) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:CHRNA7) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:CHRNB4) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:FKBP4) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:FKBP5) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:FYN) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:GABRB3) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:HSP90AB1) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:HSPA14) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:HSPA8) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:IDE) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:ITPKB) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:LCMT1) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:LRP1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:MAPK1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:MAPT) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:MAPT, pmod(Ph)) |
| path(MESH:"Alzheimer Disease") | regulates | p(HGNC:MAPT, pmod(Ph)) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:MAPT, pmod(Ph, Ser, 396)) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:MAPT, pmod(Ph, Ser, 404)) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:MAPT, pmod(Ph, Thr, 231)) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:MME) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:MMP2) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:PPID) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:PPP5C) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:PRKCB) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:SIRT1) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNC:TCP1) |
| path(MESH:"Alzheimer Disease") | increases | p(HGNC:TGM2) |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| path(MESH:"Alzheimer Disease") | increases | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNCGENEFAMILY:"Glutamate ionotropic receptor AMPA type subunits") |
| path(MESH:"Alzheimer Disease") | decreases | p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") |
| path(MESH:"Alzheimer Disease") | decreases | p(MESH:Neprilysin) |
| path(MESH:"Alzheimer Disease") | increases | p(MGI:Il6) |
| path(MESH:"Alzheimer Disease") | increases | p(MGI:Stat3, pmod(Ph)) |
| path(MESH:"Alzheimer Disease") | increases | p(MGI:Tnf) |
| path(MESH:"Amyotrophic Lateral Sclerosis") | decreases | a(MESH:"Brain Stem") |
| path(MESH:"Amyotrophic Lateral Sclerosis") | decreases | a(MESH:"Pyramidal Tracts") |
| path(MESH:"Amyotrophic Lateral Sclerosis") | increases | p(HGNC:RNF19A) |
| path(MESH:"Brain Injuries, Traumatic") | decreases | a(HP:"glymphatic system") |
| path(MESH:"Brain Injuries, Traumatic") | decreases | p(HGNC:AQP4) |
| path(MESH:"Brain Injuries, Traumatic") | increases | p(HGNC:MAPT) |
| path(MESH:"Breast Neoplasms") | increases | p(HGNC:CHRNA10) |
| path(MESH:"Breast Neoplasms") | increases | p(HGNC:CHRNA5) |
| path(MESH:"Breast Neoplasms") | increases | p(HGNC:CHRNA9) |
| path(MESH:"Down Syndrome") | increases | a(HBP:HBP00018) |
| path(MESH:"Frontotemporal Dementia") | increases | p(HGNC:ABL1) |
| path(MESH:"Frontotemporal Dementia") | increases | p(HGNC:CTSD) |
| path(MESH:"Frontotemporal Dementia") | increases | p(HGNC:TFEB) |
| path(MESH:"Frontotemporal Dementia") | increases | r(HGNC:LAMP1) |
| path(MESH:"Frontotemporal Dementia") | increases | r(HGNC:TFEB) |
| path(MESH:"Huntington Disease") | decreases | p(HGNC:HSP90AB1) |
| path(MESH:"Huntington Disease") | decreases | p(HGNC:HSPA14) |
| path(MESH:"Huntington Disease") | decreases | p(HGNC:HSPA8) |
| path(MESH:"Huntington Disease") | decreases | p(HGNC:TCP1) |
| path(MESH:"Lung Neoplasms") | increases | p(HGNC:CHRNA10) |
| path(MESH:"Lung Neoplasms") | increases | p(HGNC:CHRNA5) |
| path(MESH:"Lung Neoplasms") | increases | p(HGNC:CHRNA9) |
| path(MESH:"Parkinson Disease") | decreases | a(MESH:"Dopaminergic Neurons") |
| path(MESH:"Prion Diseases") | increases | a(HBP:"amyloid-beta aggregates") |
| path(MESH:"Proteostasis Deficiencies") | decreases | p(MGI:Mapt, var("p.Pro301Leu")) |
| path(MESH:"RING Finger Domains") | increases | complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) |
| path(MESH:"Spinal Cord Injuries") | increases | a(CHEBI:ATP) |
| path(MESH:"Spinal Cord Injuries") | increases | complex(GO:"NLRP1 inflammasome complex") |
| path(MESH:"Spinal Cord Injuries") | increases | p(HGNC:IL18) |
| path(MESH:"Spinal Cord Injuries") | increases | p(HGNC:IL1B) |
| path(MESH:"Stress Disorders, Traumatic") | increases | p(MESH:"corticotropin releasing factor-binding protein") |
| path(MESH:"Supranuclear Palsy, Progressive") | increases | a(GO:"neurofibrillary tangle") |
| path(MESH:"Supranuclear Palsy, Progressive") | increases | a(HBP:HBP00045) |
| path(MESH:"Supranuclear Palsy, Progressive") | increases | p(ECCODE:"3.1.1.89") |
| path(MESH:"Supranuclear Palsy, Progressive") | decreases | p(HGNC:LCMT1) |
| path(MESH:"Supranuclear Palsy, Progressive") | increases | p(HGNC:TGM1) |
| path(MESH:"Supranuclear Palsy, Progressive") | increases | r(HBP:"TGM2 Isoform 3 (349 aa)") |
| path(MESH:"Supranuclear Palsy, Progressive") | increases | r(HGNC:TGM1) |
| path(MESH:"Supranuclear Palsy, Progressive") | increases | r(HGNC:TGM2) |
| path(MESH:"Tobacco Use Disorder") | increases | a(HBP:"alpha-4 beta-2 nAChR") |
| path(MESH:"Trauma, Nervous System") | increases | complex(GO:"inflammasome complex") |
| path(MESH:"Trauma, Nervous System") | increases | r(HGNC:CHRNA3) |
| path(MESH:Aging) | increases | a(GO:"cytoplasmic vesicle") |
| path(MESH:Aging) | decreases | a(MESH:"Cerebrospinal Fluid") |
| path(MESH:Aging) | decreases | p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") |
| path(MESH:Aging) | increases | p(MESH:"Membrane Transport Proteins") |
| path(MESH:Aging) | decreases | p(MESH:"Mitogen-Activated Protein Kinases") |
| path(MESH:Aging) | decreases | p(MGI:Chrna4) |
| path(MESH:Aging) | increases | p(MGI:Hif1an) |
| path(MESH:Aging) | increases | p(MGI:Nfkb1) |
| path(MESH:D000544) | decreases | a(HBP:"3R tau") |
| path(MESH:D000544) | decreases | a(MESH:D059329) |
| path(MESH:D000544) | increases | a(MESHC:"pro-nerve growth factor, human") |
| path(MESH:D000544) | decreases | complex(a(CHEBI:"magnesium(2+)"), p(GFAM:"Glutamate ionotropic receptor NMDA type subunits")) |
| path(MESH:D000544) | increases | g(HGNC:NGFR) |
| path(MESH:D000544) | decreases | g(HGNC:NTRK1) |
| path(MESH:D000544) | decreases | g(HGNC:NTRK2) |
| path(MESH:D000544) | decreases | g(HGNC:NTRK3) |
| path(MESH:D000544) | decreases | p(HGNC:ACHE) |
| path(MESH:D000544) | increases | p(HGNC:BCHE) |
| path(MESH:D000544) | decreases | p(HGNC:CHAT) |
| path(MESH:D000544) | increases | p(HGNC:MMP9) |
| path(MESH:D000544) | increases | p(HGNC:NGF) |
| path(MESH:D000544) | decreases | p(HGNC:NTRK1) |
| path(MESH:D000544) | decreases | r(GFAM:Synaptotagmins) |
| path(MESH:D000544) | increases | r(HGNC:CHRNA7) |
| path(MESH:D000544) | increases | r(HGNC:CTSD) |
| path(MESH:D000544) | decreases | r(HGNC:PPP1CA) |
| path(MESH:D000544) | decreases | r(HGNC:PPP1CC) |
| path(MESH:D000544) | decreases | r(HGNC:SYP) |
| path(MESH:D003704) | decreases | p(HGNC:ACHE) |
| path(MESH:D060825) | decreases | a(HBP:"3R tau") |
| path(MESH:D060825) | decreases | a(MESH:D013569) |
| path(MESH:D060825) | increases | a(MESHC:"pro-nerve growth factor, human") |
| path(MESH:D060825) | increases | p(HGNC:CHAT) |
| path(MESH:D060825) | increases | p(HGNC:MMP9) |
| path(MESH:Depression) | increases | a(CHEBI:choline) |
| path(MESH:Encephalomyelitis) | decreases | a(GO:"myelin sheath") |
| path(MESH:Encephalomyelitis) | increases | a(MESH:Leukocytes) |
| path(MESH:Encephalomyelitis) | increases | a(MESH:Microglia) |
| path(MESH:Encephalomyelitis) | increases | p(MGI:Ifng) |
| path(MESH:Encephalomyelitis) | increases | p(MGI:Il1b) |
| path(MESH:Encephalomyelitis) | increases | p(MGI:Rela, pmod(Ph)) |
| path(MESH:Encephalomyelitis) | increases | p(MGI:Stat3, pmod(Ph)) |
| path(MESH:Encephalomyelitis) | increases | p(MGI:Tnf) |
| path(MESH:Fasting) | decreases | p(MGI:Mapt, pmod(HBP:"O-GlcNAcylation")) |
| path(MESH:Fasting) | increases | p(MGI:Mapt, pmod(Ph)) |
| path(MESH:Fear) | increases | a(CHEBI:dopamine) |
| path(MESH:Inflammation) | increases | p(HGNC:MAPT, pmod(Ph)) |
| path(MESH:Schizophrenia) | increases | a(MESH:Hippocampus) |
| path(MESH:Schizophrenia) | decreases | p(HGNC:CHRNA7) |
| path(MESH:Sleep) | decreases | a(CHEBI:"amyloid-beta") |
| path(MESH:Sleep) | increases | a(MESH:"Blood-Brain Barrier") |
| path(MESH:Starvation) | increases | p(HGNC:MAPT) |
| path(MESH:Stroke) | increases | complex(GO:"inflammasome complex") |
| path(MESH:Tauopathies) | increases | p(MGI:Ctsd) |
| path(MESH:Tauopathies) | increases | p(MGI:Lamp1) |
| path(MESH:Tauopathies) | increases | p(MGI:Tfeb) |